TWI716913B - Salicylic acid gel complex and preparation method thereof - Google Patents

Abstract

A salicylic acid gel complex and preparation method thereof is provided, wherein the salicylic acid gel complex is obtained by ultrasonic homogenization. The salicylic acid gel complex comprises: 0.5~37 wt% of salicylic acid composition; 11.5~13.0 wt% of poloxamer; 5.0~10.0 wt% of glycerin; 0.5~1.0 wt% of lecithin; 0.5~1.0 wt% of cholesterol; and the rest is refined water. Wherein, the salicylic acid composition comprises salicylic acid, mandelic acid and PPG-26-Buteth-26.

Description

Salicylic acid gel compound and preparation method thereof

The invention relates to a gel compound and a preparation method thereof, in particular to a supramolecular salicylic acid gel compound and a preparation method thereof.

Due to the accelerated pace of industrialized life and fierce job competition, the pressure of modern people also increases, resulting in hormonal imbalance. In addition, the increased pollution of the outside atmosphere and poor facial cleansing have caused confusion in facial oil secretion. The normal oil secretion function of the pores is destroyed, resulting in blockages, providing a breeding ground for the proliferation of acne bacilli. Combining the above reasons, acne diseases or common acne and inflammation phenomena also follow. Therefore, it is urgent to choose products that are mild, non-irritating and effective for acne treatment. At present, most acne products on the market often contain alcohol, which can easily irritate acne wounds and cause early inflammation or allergies, which will make consumers disgusted and stop using them. Therefore, choosing non-alcoholic and effective acne treatment products has become the only choice.

The purpose of the present invention is to provide a new type of supramolecular salicylic acid gel complex and its preparation method, through the active substance compounding of the salicylic acid complex composition, to provide a product that can be used for long-term skin with sensitive and acne-inflamed skin .

In order to achieve the above objective, the present invention provides a supramolecular salicylic acid gel complex, which is prepared by subjecting a salicylic acid complex solution to ultrasonic homogenization treatment. The salicylic acid complex solution contains: 0.5~37wt% a salicylic acid composition; 11.5~13.0wt% poloxamer; 5.0~10.0wt% glycerin; 0.5~1.0wt% lecithin ; 0.5~1.0wt% cholesterol (cholesterol); and the remainder is purified water. Among them, the salicylic acid composition includes salicylic acid, mandelic acid, and PPG-26-buteth-26 (PPG-26-Buteth-26).

The salicylic acid composition (including salicylic acid, mandelic acid, and PPG-26-butanol-26) is added to the formula, which can effectively solve the irritation and wounds caused by consumers when using acne products Melanin deposition. Since the gel composition of the present invention contains PPG-26-butanol-26, it can promote the strong transdermal absorption of the penetrant, so that salicylic acid can easily dissolve acne deeply and strengthen mandelic acid to inhibit inflammation. The calming effect, so it can improve transdermal absorption and exert greater effect. The combination of mandelic acid can inhibit the pigmentation caused by inflammation. The gel compound of the present invention also does not use preservatives, can reduce allergies, and is mild and non-irritating. In addition, the super-molecular nanostructure of the salicylic acid complex can make the product easier to exert long-term effects and provide a long-term acne-free state.

Preferably, the weight percentages of salicylic acid, mandelic acid, and PPG-26-butanol-26 are 0.5 to 2.0 wt%, 3.0 to 5.0 wt%, and 20.0 to 30.0 wt%, respectively.

Preferably, the salicylic acid complex solution of the present invention contains: 2.0wt% salicylic acid, 5.0wt% mandelic acid, 25wt% PPG-26-butanol-26, 12.0wt% Polo Sham, 8.0wt% glycerin, 0.8wt% lecithin, 0.5wt% cholesterol, and the balance is purified water.

Another object of the present invention is to provide a method for preparing the above-mentioned supramolecular salicylic acid gel complex, which includes the following steps: (1) adding salicylic acid and mandelic acid to PPG-26-butanol polyether-26 and stirring Dissolve to obtain the first mixture; (2) Mix the lecithin, cholesterol, glycerin and purified water and heat to 60~100℃, add the high pressure homogenizer, and control the temperature of the external refrigerating device at 2~10℃ for homogenization treatment , Process the solution to a particle size of 30~100nm to obtain a second mixture; (3) After mixing the second mixture with Paloxamer Add a vertical mill to process until it is completely homogenized to obtain the nanopaloxamer suspension solution as the third mixture; (4) The first mixture, the second mixture, and the third mixture are respectively homogenized with an ultrasonic homogenizer, After all the homogenization is completed, the particle size is uniform and there is no change before mixing to obtain the salicylic acid gel complex.

The supramolecular salicylic acid gel complex provided by the present invention has an excellent effect of treating acne, and no alcohol solvent is used, which greatly reduces the irritation of acne inflammation. Through the use of polyether solvents, it can improve transdermal absorption and exert greater effects. The combined use of mandelic acid can inhibit the effect of inflammatory pigmentation. The salicylic acid gel complex of the present invention also does not use preservatives, which can reduce allergies. Therefore, the novel supramolecular salicylic acid gel complex provided by the present invention can satisfy consumers with acne treatment needs, and provide consumers with peace of mind to use without worrying about any adverse reactions.

Preferably, the high-pressure homogenizer may include a main casing, a high-pressure homogenization module arranged on the main casing, and a homogenization valve arranged in the high-pressure homogenization module. The high-pressure homogenization module can be connected to the inlet and outlet. The high-pressure homogenization module is also connected to the plunger, the pressure gauge, the first manual pressure regulator, and the second manual pressure regulator respectively. A cooling device inlet is provided on the outer surface of the main casing of the high-pressure homogenization module.

The high-pressure homogenization module adopts a single SAF2507 special high-density two-way special stainless steel forging module. The homogenizing valve can adopt German KFC high-strength, high-hardness and high-density composite carbide valve group, which has high wear resistance and adopts a double-sided design. The pressure gauge can be a sanitary diaphragm type digital pressure gauge; in addition, a manual regulator is also used for homogeneous pressure adjustment.

Preferably, the upper part of the main casing is provided with a console, and the side of the main casing is provided with a plurality of vent holes.

Preferably, the feed temperature of the high-pressure homogenizer is less than 90°C, and the homogenization pressure is less than 2000 bar.

Preferably, the output power of the ultrasonic homogenizer is 250W, and the output frequency is 20KHz.

Preferably, the ultrasonic homogenizer adopts titanium alloy as the material and adopts a multi-connected tool head design. The use of titanium alloy as the material can improve the efficiency of vibration transmission, the radiation head can withstand 600 degrees high temperature, and the equipment uses The service life is improved; the multi-connected tool head design can effectively increase the ultrasonic radiation area and make the internal material radiation more uniform.

Preferably, the preparation method of the supramolecular salicylic acid gel complex provided by the present invention specifically includes the following steps: (1) adding salicylic acid and mandelic acid to PPG-26-butanol-26 Stir and dissolve to obtain the first mixture; (2) Mix the lecithin, cholesterol, glycerin and purified water and heat to 80°C, add to the high-pressure homogenizer for treatment, 4 cycles of treatment back and forth, and external refrigeration device to control the temperature at 4°C. The particle size of the solution is 50 nm to obtain a second mixture; (3) the second mixture is mixed with paloxamer and treated with a vertical mill to be completely homogeneous to obtain a nanopaloxamer suspension solution as the third mixture; (4) The first mixture, the second mixture, and the third mixture are respectively homogenized with an ultrasonic homogenizer for 10 minutes, and then stand for 120 minutes after the homogenization is completed, and the particle size is uniform and unchanged after mixing to obtain salicylic acid Gel complex.

The supramolecular salicylic acid gel complex provided by the present invention is combined with the salicylic acid complex composition, which can have a repairing effect on the facial skin that already has acne. And no alcohol solvent is used, which can greatly reduce the irritation of acne inflammation. The replacement of a new generation of solvents can make the transdermal absorption effect better, gently remove excess cutin and acne, and can enhance transdermal absorption and exert greater effects. The combined use of mandelic acid can inhibit the effect of inflammatory pigmentation. In addition, the use of no preservatives can reduce skin allergies and become cosmetics with significant anti-acne and anti-allergic effects.

The following detailed descriptions are provided with specific embodiments in conjunction with the accompanying drawings to make it easier to understand the purpose, technical content, features, and effects of the present invention.

1: No mainframe

2: High pressure homogenization module

3: feed port

4: Outlet

5: Plunger

6: Pressure gauge

7: The first manual pressure regulator

8: The second manual pressure regulator

9: Cooling device inlet

10: console

11: Vent

12: Feed pipe

13: Feed valve

Fig. 1 is a schematic diagram of a high-pressure homogenizer according to an embodiment of the present invention.

The present invention will be further described below in conjunction with specific embodiments, but the scope of protection of the present invention is not limited to this.

Example 1

The processing inner material is 51.7kg of refined water, 20.0kg of PPG-26-Buteth-26 (PPG-26-Buteth-26), 12.0kg of poloxamer, 8.0kg of glycerin, 5.0 kg of mandelic acid, 2.0 kg of salicylic acid, 0.8 kg of lecithin, and 0.5 kg of cholesterol (cholesterol). The preparation method of the salicylic acid gel compound of the present invention includes the following steps: (1) First, the composition of the inner material, salicylic acid and mandelic acid, is put into PPG-26-butanol-26, stirred and dissolved, and treated as the first A mixture is ready for use; (2) The composition of the inner material is mixed with lecithin/cholesterol/glycerin/refined water and heated to 80°C, put into a high-pressure homogenizer for treatment, and 4 cycles of treatment are performed back and forth, and an external refrigeration device controls the temperature at 4°C. Processed to the particle size of the solution to 50nm, as the second mixture solution for later use; (3) Mix the second mixture solution with poloxamer, and use a vertical mill to process until it is completely dispersed to obtain a nanopoloxamer suspension solution Standby, as the third mixture solution; (4) After that, take appropriate amounts of the first mixture, second mixture, and third mixture, and disperse them with an ultrasonic disperser for 10 minutes. After all the dispersion is completed, let stand for 120 Minutes later, the particle size is uniform and there is no change and then mixed to obtain a new type of supramolecular salicylic acid gel complex.

1, the high-pressure homogenizer includes a main casing 1, a high-pressure homogenization module 2 arranged on the main casing, and a homogenization valve arranged in the high-pressure homogenization module, the high-pressure homogenization module and the feed port 3. The discharge port 4 is connected, and the feed port 3 is connected to the high-pressure homogenization module through a feed pipe 12, and the feed pipe 12 is provided with a feed valve 13, which can effectively adjust the feed amount. The high-pressure homogenization module is also connected to the plunger 5, the pressure gauge 6, the first manual pressure regulator 7, and the second manual pressure regulator 8, respectively, and a cooling device inlet 9 is provided on the outer surface of the main casing. The homogenization pressure can be well adjusted by the first manual pressure regulator 7 and the second manual pressure regulator 8. By connecting with an external cooling device, the homogenization temperature can be better controlled without being affected by the workshop environment temperature.

The high-pressure homogenization module adopts a single SAF2507 special high-density bidirectional special stainless steel forging module. The plunger is processed with high-purity zirconia, and the surface is polished to 0.15 u. It has high wear resistance and can be used at both ends; the homogenization valve can use German KFC The high-strength, high-hardness and high-density composite hard alloy valve group has high wear resistance and adopts a double-sided design. The pressure gauge can be a sanitary diaphragm type digital pressure gauge.

The upper part of the main casing is provided with a console 10, and the side of the main casing is provided with a plurality of vent holes 11. The frequency converter control system can adjust the flow rate according to the requirements, with a built-in cooler and heat dissipation through the through holes, without consuming materials, and controlling the homogeneous temperature.

The feed temperature of the high-pressure homogenizer is less than 90°C, and the homogenizing pressure is less than 2000 bar. The output power of the ultrasonic homogenizer is 250W, and the output frequency is 20KHz. The ultrasonic homogenizer adopts titanium alloy as the material and adopts the design of multi-connected tool heads, and uses titanium alloy as the material to improve the vibration transmission efficiency. The radiating head can withstand 600 degrees of high temperature and the service life of the equipment is improved; adopts the multi-connected tool head design, Effectively increase the ultrasonic radiation area, making the internal material radiation more uniform.

The inner wall of the high-pressure homogenizer and the ultrasonic homogenizer head of the present invention are made of SUS 316 stainless steel, which is acid and alkali resistant, timeable, temperature controllable, and convenient for operation.

Through the use of the lecithin emulsifier in the formula and the combination with a high-pressure homogenizer, the particle size of the final product can be effectively reduced. The size of the emulsified particle size is determined by the number of homogenizations. The collision of various turbulences during emulsification produces High-frequency vibration of cavitation produces shearing force with the edge of the homogenization valve and impact force with the baffle of the homogenization valve. The temperature is controlled at 4℃ through the cooling device, and the emulsification cycle is repeated many times, and then reaches the final 50nm particle in the product. path.

Through the synergistic effect of the formula, the high-pressure homogenizer and the ultrasonic homogenizer, the invention solves the problem that after the traditional ultrasonic homogenization equipment is produced, the internal material is naturally left for 120 minutes, and the supramolecular internal material particle size and the final viscosity cannot be effectively controlled. To achieve the goal of controlling the particle size and viscosity of the internal material well, it is not affected by the ambient temperature of the workshop.

In order to understand the effect of the present invention, an extensive trial survey was carried out on this product in the form of a questionnaire survey. A total of 950 trial subjects were included in the survey, including 400 men and 550 women. The oldest was 48 years old and the youngest was 18 years old. About 28 years old, a total of 750 valid questionnaires were collected.

After 750 trial persons used the new supramolecular salicylic acid gel complex of the present invention for 28 days, they conducted self-evaluation on various indicators related to acne allergy repair. The results are as follows: (1) Restore skin complexion: respectively 75.5% and 89.3% of the trial participants had moderate and significant improvement; (2) Soothing skin inflammation: 80.1% and 93.5% of trial participants had moderate and significant improvement; and (3) Reduced the skin allergy rate : 72.8% and 85.9% of trial users have moderate improvement and obvious improvement. It can be seen from the self-assessment results of testers that the novel supramolecular salicylic acid gel complex of the present invention has significant improvements in varying degrees of skin complexion, soothing skin inflammation, and skin allergies.

Example 2

The processing contents are 59.0kg of refined water, 20.0kg of PPG-26-butanol-26, 11.5kg of poloxamer, 5.0kg of glycerin, 3.0kg of mandelic acid, 0.5kg of salicylic acid, 0.5kg of lecithin, and 0.5kg of cholesterol. The preparation method of the salicylic acid gel compound of the present invention includes the following steps: (1) First, the composition of the inner material, salicylic acid and mandelic acid, is put into PPG-26-butanol-26, stirred and dissolved, and treated as the first A mixture is ready for use; (2) The composition of the inner material is mixed with lecithin/cholesterol/glycerin/refined water and heated to 80°C, put into a high-pressure homogenizer for treatment, and 4 cycles of treatment are performed back and forth, and an external refrigeration device controls the temperature at 4°C. Treat the solution until the particle size of the solution is 50nm, and use it as the second mixture solution for later use; (3) Mix the second mixture solution with poloxamer, and then use a vertical mill to process until it is completely dispersed to obtain the nanopoloxamer suspension The solution is ready for use, as the third mixture solution; (4) After that, take appropriate amounts of the first mixture, second mixture, and third mixture, and disperse them with an ultrasonic homogenizer for 10 minutes, until all the dispersion is completed, and then stand for 120 Minutes later, the particle size is uniform and there is no change and then mixed to obtain a new type of supramolecular salicylic acid gel complex.

In order to understand the effect of the present invention, an extensive trial survey was carried out on this product in the form of a questionnaire survey. A total of 950 trial subjects were included in the survey, including 400 men and 550 women. The oldest was 48 years old and the youngest was 18 years old. About 28 years old, a total of 750 valid questionnaires were collected.

After 750 trial persons used the new supramolecular salicylic acid gel complex of the present invention for 28 days, they conducted self-evaluation on various indicators related to acne allergy repair. The results are as follows: (1) Restore skin complexion: respectively 68.2% and 85.2% of the trial users had moderate and significant improvement; (2) soothing skin inflammation: 70.3% and 90.4% of the trial users had moderate and significant improvement; and (3) reduced the skin allergy rate : 68.4% and 78.5% of trial users have moderate improvement and obvious improvement. It can be seen from the self-assessment results of testers that the novel supramolecular salicylic acid gel complex of the present invention has significant improvements in varying degrees of skin complexion, soothing skin inflammation, and skin allergies.

Example 3

The processing contents are 47.9kg of refined water, 25.0kg of PPG-26-butanol-26, 12.5kg of poloxamer, 8.0kg of glycerin, 4.0kg of mandelic acid, 1.0kg of salicylic acid, 0.8kg of lecithin, and 0.8kg of cholesterol. The preparation method of the salicylic acid gel compound of the present invention includes the following steps: (1) First, the composition of the inner material, salicylic acid and mandelic acid, is put into PPG-26-butanol-26, stirred and dissolved, and treated as water The salicylic acid solution is used as the first mixture for later use; (2) The composition of the inner material is mixed with lecithin/cholesterol/glycerin/refined water and heated to 80℃, put into a high-pressure homogenizer for processing, and 4 cycles of processing back and forth, external refrigeration device Control the temperature at 4°C, and process the solution until the particle size of the solution reaches 50nm, and use it as a second mixture solution for later use; (3) Mix the second mixture solution with poloxamer, and use a vertical mill to process until it is completely dispersed to obtain nanopo The loxamer suspension solution is ready for use, and it is used as the third mixture solution; after that, the first mixture, the second mixture, and the third mixture are taken in an appropriate amount, and the ultrasonic dispersion machine is used to disperse for 10 minutes. After being placed for 120 minutes, the particle size is uniform and there is no change before mixing to obtain a new supramolecular salicylic acid gel complex.

In order to understand the effect of the present invention, an extensive trial survey was carried out on this product in the form of a questionnaire survey. A total of 950 trial subjects were included in the survey, including 400 men and 550 women. The oldest was 48 years old and the youngest was 18 years old. About 28 years old, a total of 750 valid questionnaires were collected.

After 750 trial persons used the new supramolecular salicylic acid gel complex of the present invention for 28 days, they conducted self-evaluation on various indicators related to acne allergy repair. The results are as follows: (1) Restore skin complexion: respectively 70.6% and 86.9% of the trial participants had moderate and significant improvement; (2) Soothing skin inflammation: 75.7% and 91.3% of trial participants had moderate and significant improvement, respectively; and (3) Reduced the skin allergy rate : 70.2% and 80.5% of trial users have moderate improvement and obvious improvement. It can be seen from the self-assessment results of testers that the novel supramolecular salicylic acid gel complex of the present invention has significant improvements in varying degrees of skin complexion, soothing skin inflammation, and skin allergies.

Example 4

The processing contents are 38kg of refined water, 30kg of PPG-26-butanol-26, 13kg of poloxamer, 10kg of glycerin, 5kg of mandelic acid, 2kg of salicylic acid, 1kg of lecithin, and 1kg of cholesterol. The preparation method of the salicylic acid gel compound of the present invention includes the following steps: (1) First, the composition of the inner material, salicylic acid and mandelic acid, is put into PPG-26-butanol-26, stirred and dissolved, and treated as the first A mixture is ready for use; (2) The composition of the inner material is mixed with lecithin/cholesterol/glycerin/refined water and heated to 80°C, put into a high-pressure homogenizer for treatment, and 4 cycles of treatment are performed back and forth, and an external refrigeration device controls the temperature at 4°C. Processed to the particle size of the solution to 50nm, as the second mixture solution for later use; (3) Mix the second mixture solution with poloxamer, and use a vertical mill to process until it is completely dispersed to obtain a nanopoloxamer suspension solution Standby, as the third mixture solution; (4) After that, take appropriate amounts of the first mixture, second mixture, and third mixture, and disperse them with an ultrasonic disperser for 10 minutes. After all the dispersion is completed, let stand for 120 minutes After mixing, the particle size is uniform and unchanged to obtain a new type of supramolecular salicylic acid gel complex.

In order to understand the effect of the present invention, an extensive trial survey was carried out on this product in the form of a questionnaire survey. A total of 950 trial subjects were included in the survey, including 400 men and 550 women. The oldest was 48 years old and the youngest was 18 years old. About 28 years old, a total of 750 valid questionnaires were collected.

After 750 trial persons used the new supramolecular salicylic acid gel complex of the present invention for 28 days, they conducted self-evaluation on various indicators related to acne allergy repair. The results are as follows: (1) Restore skin complexion: respectively 67.3% and 83.5% of the trial participants had moderate and significant improvement; (2) Soothing skin inflammation: 70.7% and 89.7% of the trial participants had moderate and significant improvement; and (3) Reduced the skin allergy rate : 66.7% and 77.3% of trial users have moderate and significant improvements. It can be seen from the self-assessment results of testers that the novel supramolecular salicylic acid gel complex of the present invention has significant improvements in varying degrees of skin complexion, soothing skin inflammation, and skin allergies.

Example 5

The processing internal materials are 42.8kg of refined water, 28.3kg of PPG-26-butanol-26, 12.5kg of poloxamer, 9.5kg of glycerin, 4.0kg of mandelic acid, 1.5kg of salicylic acid, 0.7kg of lecithin, and 0.7kg of cholesterol. The preparation method of the salicylic acid gel compound of the present invention includes the following steps: (1) First, the composition of the inner material, salicylic acid and mandelic acid, is put into PPG-26-butanol-26, stirred and dissolved, and treated as the first A mixture is ready for use; (2) The composition of the inner material is mixed with lecithin/cholesterol/glycerin/refined water and heated to 80°C, put into a high-pressure homogenizer for treatment, and 4 cycles of treatment are performed back and forth, and an external refrigeration device controls the temperature at 4°C. Processed to the particle size of the solution to 50nm, as the second mixture solution for later use; (3) Mix the first mixture solution with poloxamer, and use a vertical mill to process until it is completely dispersed to obtain a nanopoloxamer suspension solution Standby, as the third mixture solution; (4) After that, take appropriate amounts of the first mixture, second mixture, and third mixture, and disperse them with an ultrasonic disperser for 10 minutes. After all the dispersion is completed, let stand for 120 minutes After mixing, the particle size is uniform and unchanged to obtain a new type of supramolecular salicylic acid gel complex.

In order to understand the effect of the present invention, an extensive trial survey was carried out on this product in the form of a questionnaire survey. A total of 950 trial subjects were included in the survey, including 400 men and 550 women. The oldest was 48 years old and the youngest was 18 years old. About 28 years old, a total of 750 valid questionnaires were collected.

After 750 trial persons used the new supramolecular salicylic acid gel complex of the present invention for 28 days, they conducted self-evaluation on various indicators related to acne allergy repair. The results are as follows: (1) Restore skin complexion: respectively 72.1% and 85.9% of the trial participants had moderate and significant improvement; (2) Soothing skin inflammation: 77.2% and 91.4% of the trial participants had moderate and significant improvement; and (3) reduced the skin allergy rate : 71.1% and 81.3% of trial users have moderate and significant improvements. It can be seen from the self-assessment results of testers that the novel supramolecular salicylic acid gel complex of the present invention has significant improvements in varying degrees of skin complexion, soothing skin inflammation, and skin allergies.

Example 6

The processing content is 53.3kg of refined water, 22.3kg of PPG-26-butanol-26, 12kg of poloxamer, 6.5kg of glycerin, 3.5kg of mandelic acid, 0.8kg of salicylic acid, 0.9 kg of lecithin, and 0.7 kg of cholesterol. The preparation method of the salicylic acid gel compound of the present invention includes the following steps: (1) First, the composition of the inner material, salicylic acid and mandelic acid, is put into PPG-26-butanol-26, stirred and dissolved, and treated as the first A mixture is ready for use; (2) The composition of the inner material is mixed with lecithin/cholesterol/glycerin/refined water and heated to 80°C, put into a high-pressure homogenizer for treatment, and 4 cycles of treatment are performed back and forth, and an external refrigeration device controls the temperature at 4°C. Processed to the particle size of the solution to 50nm, as the second mixture solution for later use; (3) Mix the second mixture solution with poloxamer, and use a vertical mill to process until it is completely dispersed to obtain a nanopoloxamer suspension solution Standby, as the third mixture solution; (4) After that, take appropriate amounts of the first mixture, second mixture, and third mixture, and disperse them with an ultrasonic disperser for 10 minutes. After all the dispersion is completed, let stand for 120 minutes After mixing, the particle size is uniform and unchanged to obtain a new type of supramolecular salicylic acid gel complex.

In order to understand the effect of the present invention, an extensive trial survey was carried out on this product in the form of a questionnaire survey. A total of 950 trial subjects were included in the survey, including 400 men and 550 women. The oldest was 48 years old and the youngest was 18 years old. About 28 years old, a total of 750 valid questionnaires were collected.

After 750 trial persons used the new supramolecular salicylic acid gel complex of the present invention for 28 days, they conducted self-evaluation on various indicators related to acne allergy repair. The results are as follows: (1) Restore skin complexion: respectively 70.1% and 85.9% of the trial participants had moderate and significant improvement; (2) Soothing skin inflammation: 73.7% and 90.6% of the trial participants had moderate and significant improvements, respectively; and (3) reduced the skin allergy rate : 69.5% and 80.2% of trial users have moderate improvement and obvious improvement. It can be seen from the self-assessment results of testers that the novel supramolecular salicylic acid gel complex of the present invention has significant improvements in varying degrees of skin complexion, soothing skin inflammation, and skin allergies.

The above-mentioned embodiments are only to illustrate the technical ideas and features of the present invention, and their purpose is to enable those who are familiar with the art to understand the content of the present invention and implement them accordingly. When they cannot be used to limit the patent scope of the present invention, That is, all equal changes or modifications made in accordance with the spirit of the present invention should still be covered by the patent scope of the present invention.

1: mainframe

2: High pressure homogenization module

3: feed port

4: Outlet

5: Plunger

6: Pressure gauge

7: The first manual pressure regulator

8: The second manual pressure regulator

9: Cooling device inlet

10: console

11: Vent

12: Feed pipe

13: Feed valve

Claims (10)

A salicylic acid gel complex, which is prepared by subjecting a salicylic acid complex solution to high-pressure homogenization treatment and ultrasonic homogenization treatment. The salicylic acid complex solution contains: 0.5~37wt% of salicylic acid Acid composition; 11.5~13.0wt% poloxamer; 5.0~10.0wt% glycerin; 0.5~1.0wt% lecithin; 0.5~1.0wt% cholesterol; and the remainder is purified water; The salicylic acid composition includes salicylic acid, mandelic acid, and PPG-26-butanol-26. The salicylic acid gel compound according to claim 1, wherein the weight percentage of salicylic acid is 0.5 to 2.0 wt%, the weight percentage of mandelic acid is 3.0 to 5.0 wt%, and the PPG-26-butanol poly The weight percentage of ether-26 is 20.0~30.0wt%. The salicylic acid gel compound according to claim 1, wherein the weight percentage of salicylic acid is 2.0 wt%, the weight percentage of mandelic acid is 5.0 wt%, and the weight of PPG-26-butanol-26 The percentage is 25 wt%, the weight percentage of poloxamer is 12.0 wt%, the weight percentage of glycerin is 8 wt%, the lecithin 0.8 wt%, the weight percentage of cholesterol is 0.5 wt%, and the remainder is purified water. A method for preparing the salicylic acid gel complex according to claim 1, comprising the following steps: Add salicylic acid and mandelic acid to PPG-26-butanol-26 and stir to dissolve to obtain a first mixture; mix lecithin, cholesterol, glycerin and purified water and heat to 60~100℃, add one After the high-pressure homogenizer, perform homogenization treatment at a temperature of 2-10°C to obtain a second mixture. The solution particle size of the second mixture is 30-100nm; the second mixture is mixed with Paloxamer and then added to a grinder Processing to complete homogenization to obtain a nanopaloxamer suspension solution as a third mixture; and the first mixture, the second mixture, and the third mixture are respectively homogenized by an ultrasonic homogenizer until After all the homogenization is completed, the particle size is uniform without change and then mixed to obtain the salicylic acid gel complex. The method for preparing a salicylic acid gel compound according to claim 4, wherein the high-pressure homogenizer comprises a main housing, a high-pressure homogenizing module arranged on the main housing, and a high-pressure homogenizing mold A homogenization valve in the group, the high-pressure homogenization module is connected to a feed port and a discharge port, and the high-pressure homogenization module is also respectively connected with a plunger, a pressure gauge, a first manual pressure regulator, and A second manual pressure regulator is connected, and a cooling device inlet is provided on the outer surface of the main casing. The preparation method of the salicylic acid gel compound according to claim 5, wherein the upper part of the main casing is provided with a control panel, and the side of the main casing is provided with a plurality of vent holes. The method for preparing a salicylic acid gel composite according to claim 5, wherein the feed temperature of the high-pressure homogenizer is less than 90° C., and the homogenization pressure is less than 2000 bar. The method for preparing a salicylic acid gel compound according to claim 4, wherein the output power of the ultrasonic homogenizer is 250W, and the output frequency is 20KHz. The preparation method of the salicylic acid gel composite according to claim 4, wherein the ultrasonic homogenizer is made of titanium alloy and adopts a multi-joint tool head design. The preparation method of the salicylic acid gel complex according to claim 4, wherein: lecithin, cholesterol, glycerin and purified water are mixed and heated to 80°C and added to the high-pressure homogenizer at a temperature of 4°C Perform 4 homogenization treatments to obtain the second mixture with a solution particle size of 50 nm; and the first mixture, the second mixture and the third mixture are respectively homogenized by the ultrasonic homogenizer 10 Minutes, after the homogenization is completed, after standing for 120 minutes, the particle size is uniform and there is no change before mixing to obtain the salicylic acid gel complex.

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