CN108379177A - The formula and its production technology of the outer product of medicine is made by mixing in a kind of Chinese herbal medicine extract - Google Patents
The formula and its production technology of the outer product of medicine is made by mixing in a kind of Chinese herbal medicine extract Download PDFInfo
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- CN108379177A CN108379177A CN201810501204.1A CN201810501204A CN108379177A CN 108379177 A CN108379177 A CN 108379177A CN 201810501204 A CN201810501204 A CN 201810501204A CN 108379177 A CN108379177 A CN 108379177A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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Abstract
The invention discloses product outside medicine are made by mixing in a kind of Chinese herbal medicine extract formulas and its production technology, belong to technical field of skin care.The Chinese herbal medicine extract of the present invention is made by mixing the formula of the outer product of medicine, including red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry extraction object, surfactant, tackifier and water；The red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry carry out mixing extraction after vacuum freeze-drying technique, inventor has found, skin care item are made after carrying out mixing extraction again after having moist moisturizing, the red ginseng of whitening drug effect, aloe, Bee Pollen, propolis and cogongrass cliff berry first to carry out vacuum freeze drying for skin these, constant drug effect and the time in skin surface moisturizing lasting effectively extend.Solves the technical problem for existing in the prior art that skin care item drug effect continues and moisturizing, fragrance remaining time are short.
Description
Technical field
The invention belongs to technical field of skin care, are made by mixing outside medicine specifically, being related to a kind of Chinese herbal medicine extract
The formula and its production technology of product.
Background technology
The outer product of medicine, are commonly called as skin care item, skin care item and other personal care products are intended for skin (such as powder of people
Bottom, things concealed, eye shadow, sun-screening agent and/or imitative tanning products), antelabium (such as lipstick, real color lip gloss, lip line and bright lip gloss) and
Hair (such as mascara) generally comprises at least one fatty phase by one or more material compositions, and the substance is actually
For oil, fat or wax.According to the intended purpose of product, this fat is mutually mainly used for delivering institute to skin, antelabium, hair or nail
The characteristic needed, such as emollient, spreadability, gloss, hair conditioning and/or protective.In addition, this fat typical can mutually have as convenient
Other required ingredients are disperseed and/or are dissolved in these compositions by the medium of effect.Other required ingredients may include for example
Pigment, dyestuff and/or particulate fillers, with needed for generating in the product and on skin, antelabium, hair and/or nail
Color or light scattering and/or light reflection effect.These colors and/or optical effect typical case is in product and skin, antelabium, hair
Needed on hair and/or nail, because they can enhance visual attraction and glamour of the cosmetic product to consumer.Work as product
After being coated in skin, antelabium, hair and/or nail, since these colors and/or optical effect can be covered or be reduced carefully
The appearance of line/wrinkle or skin blemishes, and/or the colour of skin evenly is provided, and/or provide color with protrude consumer's face,
The appearance of antelabium, eye, eyelashes and/or nail, so being highly desirable.Other required ingredients for example aromatic, vitamin,
Sun-screening agent and other makeups or dermatological activity agent, also can be disperseed because of their ideal effect and/or be dissolved in these
In composition.The said goods can be mutually made of water-free (being typically referred to as anhydrous) fat, or can be by fatty phase and aqueous phase
Combination constitute, the combination can form the dispersion or lotion of Water-In-Oil (W/O) or oil-in-water (O/W) form.The said goods
It can take many forms, such as solid or club, gel, paste, creams and lotion.
The drawbacks common often experienced when consumer is using the said goods is it cannot remain initial or rigid after coating
Appearance when painting.Consumer prefers to make appearance when initial or rigid painting can keep several hours or more long (or at least above-mentioned
Minimum loss is felt in time), the trouble for being coated with recovery or restoring required appearance is applied again without having to.However,
It is excessively in liquid or easily flow that coated product film, which is generally maintained at, therefore with being easy to from skin, antelabium and/or hair
Hair is transferred to the trend on its contacted article, the article such as glassware, cup, fabric or other skins.In many days
Often in activity, the above-mentioned contact with various articles is common, and is difficult to avoid, and is touched such as diet and unintentionally
Or grazing was pre-coated with the skin, antelabium and/or hair of product film.In addition, coated film mobility usually make product
Be be easily moved and/or concentrate in the pore of microgroove, wrinkle, fold and/or skin and/or antelabium, cause it is unpleasant not
Uniform outer appearance.
For anhydrous composition (those of i.e. no aqueous phase), many trials are had been carried out previously, it can it is said that disclosing
Skin care item with durability or metastasis suppressor characteristic are provided.Most of depend on contains comprising height in the composition in these trials
Amount or a high proportion of volatile fat phase liquid component, such as volatile siloxane or hydrocarbon.Volatile fat phase constituent can be initial
When apply or sprawl, then volatilize from product after coating, leave that mobility is poor or the film of more similar solid.At above-mentioned group
It closes in object, usually also relies on the one or more high of one or more hydrophobic resins such as silicone resin and/or high-content
Fusing point wax ingredient, to deposit the rigidity of water resistant or the film of similar solid.In perspiration/sweating, washs, drinks and swims,
The resin and/or wax can assign coated film with better characteristics and water-resistance.However, applying and waving in these compositions
After the fat constituent volatilization of hair property, the film typical case obtained has the shortcomings that feel and/or too dry in appearance (i.e. very not only
It is sliding, extremely lackluster).
For W/O and O/W dispersions or emulsion compositions, the trial of early stage also has been disclosed in this field, it is stated that can carry
For the skin care item with durability or metastasis suppressor characteristic.During these are attempted, it is certain be related in aqueous phase comprising it is water-soluble at
Film or gelling agent to deliver harder or more rigid film after coating.However, after the coating of these compositions and moisture content volatilization,
The film obtained usually has the drawback that bullet highly desirable when frangible or stiff, shortage skin, antelabium and/or hair activity
Property degree and comfort level.In addition, the water solubility of above-mentioned film forming agent or gelling agent is another disadvantage, coated film is had
Lower water-resistance or water proofing property cause coated product film to be easy in perspiration/sweating, wash, drink and swim
It is wiped or is removed.
Other trials are related to that film forming polymer latex or aqueous dispersion are added in O/W and W/O composition aqueous phases.This
A little film-forming polymer types can generate water-resistance/water proofing property film on skin, antelabium and/or hair, and usually have good
Elasticity.However, certain previous trials need to include the volatile organic compound of high-content in aqueous polymer dispersion
Object (such as lower alcohol) and/or plasticizer, to reach their desired film-formation results.Mentioned component usually has the drawback that meeting pair
Skin, antelabium, hair and/or nail cause dry and/or stimulate and/or damage.In addition, the ingredient typical case of these high-contents to
Product assigns unpleasant smell and/or taste, and causes product inflammable.Another realized in being earlier attempted to is comprising fat
These film forming polymers are effectively added in the composite skin care product of fat phase is limited in that needing one or more surfaces lives
Property agent/emulsifier.According to the type and/or dosage of emulsifier, they have a disadvantage in that the adherency for interfering film forming polymer
Characteristic or film forming characteristics and/or the irritation or sensitive response for causing skin, antelabium or eye.At least use film forming polymer
Some aqueous dispersions when another limitation for encountering be after the fatty phase (typical case is higher than 40 DEG C) for heating or being added to heat,
It is easy and fast to condensation or polymer is unstable.
Through retrieval, Chinese patent publication No. CN106309245A, publication date 2017.01.11, denomination of invention：A kind of nothing adds
The cosmetic formulations of adding preservative agent contain following component in the cosmetic formulations：Dandelion extract, cogongrass cliff berry extract,
Ginkgo biloba p.e, the application in cosmetics are by dandelion extract, cogongrass cliff berry extract, ginkgo biloba p.e
Mixture is proportionally added in cosmetics.The invention provides a kind of cosmetic formulations of no added preservative, are by
Herb extracts are added in cosmetics, can effectively inhibit the growth of microorganism in cosmetics so that cosmetics are stored up for a long time
Stable, sterile performance, safe green are kept in Tibetan, but dandelion extract, cogongrass cliff berry extract, ginkgo leaf carry in the invention
Take object light sensitivity stronger, photosensitive easy failure causes that its persistence is poor, fragrance remaining time is short.
Invention content
1. technical problems to be solved by the inivention
Skin care item drug effect continues and moisturizing, fragrance remaining time are short to overcome the problems, such as to exist in the prior art, and the present invention carries
The formula and its production technology of product outside medicine are made by mixing for a kind of Chinese herbal medicine extract.The present invention is by by red ginseng, aloe, bee
Pollen, propolis and cogongrass cliff berry make after carrying out mixing extraction after vacuum freeze-drying technique, and the ingredient of various drug effects is integrated
And syncretizing effect is good, achievees the purpose that improve duration of efficacy and fragrance remaining time, and then keep medicine within a certain period of time
Effect.
2. technical solution
To solve the above problems, the present invention adopts the following technical scheme that：
The formula of the outer product of medicine, including red ginseng, aloe, Bee Pollen, propolis and thatch is made by mixing in a kind of Chinese herbal medicine extract
Extraction object, surfactant, tackifier and the water of the rock certain kind of berries；The red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry pass through vacuum
Carry out mixing extraction after freeze drying process, inventor has found, by these for skin have moist moisturizing, whitening drug effect it is red
Ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry first carry out making skin care item after carrying out mixing extraction again after vacuum freeze drying,
Constant drug effect and effectively extend in the time of skin surface moisturizing lasting.Moreover, the main component panaxoside of ginseng, is one
Kind of steroid compound, saponin not only have cleaning effect, have bactericidal effect and an antiphlogistic effects to bacterial microbes, also its
In terpene component have analgesic activity, β ocimenums, Panaxynol, linoleic acid ingredient have anti-inflammatory, antibacterial effect；Aloe juice
In Anthraquinones have effects that disinfection, the polysaccharide and multivitamin contained to human skin have good nutrition, moisten,
Whitening effect, having makes skin contraction, softness, the performance of moisturizing, anti-inflammatory, bleaching.Bee Pollen is rich in protein, carbon hydrate
Object, minerals, vitamin and other active materials, the ingredients such as VE therein, superoxide dismutase (SOD), selenium can moisten nutrition
Skin restores the elastic and bright and clean of skin；And cogongrass cliff berry active ingredient is mainly dihydromyricetin, flavones, is presently found
Flavones content is highest in all plants, " king of flavones " claimed in plant.
Further embodiment, the proportioning before red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry mixing is (2~4)：(3~
4)：(1~2)：(1~2)：(1~2)；The mixed parts by weight for extracting object are 75~80, surfactant 35~40, thickening
Agent 15~20, water 220~280, this proportioning mode, have considered the duration of cost factor and drug effect and lasting, have been
Than more preferably matching section.
Further embodiment, surfactant and tackifier are respectively glycerine and sodium alginate；The water is deionized water.
The production technology of the outer product of medicine is made by mixing in a kind of Chinese herbal medicine extract, the specific steps are：
(1) it mixes：The red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry are uniformly mixed；
(2) it heats：300 times of heavy water for adding red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry total weight, 85~
100 DEG C of temperature heats 2~3 hours；
(3) it extracts：It is transferred in extractor and extracts after heating；
(4) it filters：Extract is filtered by strainer；
(5) it prepares：After filtered extract and surfactant, tackifier are mixed, add ionized water formed it is mixed
It closes the obtained Chinese herbal medicine extract of liquid and the outer product of medicine is made by mixing.
Further production technology, red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry mixture vacuum freeze-drying
Skill step is：
(1) it cleans：Draining is stood after fresh red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry are cleaned；
(2) it shreds：It is piece that red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry after draining are transferred to shredding machine chopping according to the ratio
Or fourth；
(3) disk is spread：Disk is spread extremely from material disc along 0.5cm or less；
(4) quick-frozen：To spread the semi-finished product after disk be transferred in quick freezing repository carry out it is quick-frozen, quick freezing repository temperature require as -34 DEG C hereinafter,
220~240 minutes quick-frozen time；
(5) vacuum freeze drying：Semi-finished product after quick-frozen, which are transferred in vacuum freeze drying cabin, to be dried, after export both
Mixture tablet or fourth is lyophilized.
Further production technology, red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry mixture vacuum freeze drying
Technique further includes step：
(6) powder is beaten：Piece or fourth that red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry mixture is lyophilized are transferred to pulverizer to beat
Powder is to providing mesh number.
It further include the extraction of ginkgo biloba p.e in the step of the step of further production technology, lozenge (3) extracts：
By ginkgo leaf in non-woven fabrics sack, it is put into circulation type and extracts tank, after 80~100% alcohol for adding 12 times of weights, in room temperature
Middle cycle extracts for 3~4 hours, dispels harmful components by activated carbon, then by 0.5~1 μm of filter screen dispels suspended solid
After ginkgo leaf extraction object is made, then it is added into the preparation of step (5).
Further production technology, ginkgo leaf extract again after first carrying out vacuum freeze drying.
The vacuum freeze-drying technique step of further production technology, ginkgo leaf is：
(1) it cleans：Draining is stood after fresh ginkgo leaf is cleaned；
(2) it shreds：It is piece that ginkgo leaf after draining, which is transferred to shredding machine chopping,；
(3) disk is spread：Disk is spread extremely from material disc along 0.4cm or less；
(4) quick-frozen：To spread the semi-finished product after disk be transferred in quick freezing repository carry out it is quick-frozen, quick freezing repository temperature require as -33 DEG C hereinafter,
200~220 minutes quick-frozen time；
(5) vacuum freeze drying：Semi-finished product after quick-frozen, which are transferred in vacuum freeze drying cabin, to be dried, after export both
Powder is beaten after freeze-drying ginkgo leaf fragment.
The temperature curve of further production technology, step (5) vacuum freeze drying is：
A, temperature raising period：Inner panel temperature is warming up to 100 DEG C within 15 minutes, is evacuated to 113Pa or less；
B, distil peak period：90 DEG C of holding 4h of plate temperature drop temperature, vacuum keep 113Pa or less；
C, the medium temperature phase：Plate warm water is cold to be down to 75 DEG C of holding 6h, and vacuum keeps 60~80Pa；
D, the parsing-desiccation phase：Plate temperature is down to 65 DEG C of 1~2h of holding naturally, and vacuum keeps 40~60Pa；
E, hypothermic phase：55~60 DEG C of 1~2h of holding of plate temperature, vacuum keep 40~50Pa；
F, the short-term warming phase：Plate temperature is rapidly heated to 70~75 DEG C, and after keeping 15~30min, silver must both be lyophilized after export
Apricot leaf fragment.
3. advantageous effect
Compared with prior art, the present invention has following remarkable advantage：
(1) formula of the outer product of medicine is made by mixing in Chinese herbal medicine extract of the invention, and it is medicative various will to be directed to skin
Red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry first carry out carrying out mixing extraction after vacuum freeze drying again, constant drug effect and
Effectively extend in the time of skin surface lasting；
(2) formula of the outer product of medicine is made by mixing in Chinese herbal medicine extract of the invention, red ginseng, reed after vacuum freeze drying
Luxuriant growth, Bee Pollen and cogongrass cliff berry, the flavones in effective component therein, such as red ginseng, aloe and Bee Pollen, three kinds of flavones can be mutual
It blends, there is collaboration and effect, whitening antibacterial for skin and moist, recovery elastic effect are more preferably；
(3) formula of the outer product of medicine is made by mixing in Chinese herbal medicine extract of the invention, is carried after cogongrass cliff berry vacuum freeze drying
The fusion of the effective component tea polyphenols, dihydromyricetin and the superoxide dismutase in freeze-drying Bee Pollen that take, can further carry
Salubrious skin and lasting lasting and antibacterial effect；
(4) production technology of the outer product of medicine is made by mixing in Chinese herbal medicine extract of the invention, red after vacuum freeze drying
After ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry mixing plus water extracts, since most cells wall is pierced by tiny ice crystal after freeze-drying
It is broken, and be vesicular texture, moisture can quickly penetrate into the cell of red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry
It is interior, effective component therein can be extracted quickly, heating time is greatly reduced, avoid effective component due to long heating
It causes damages, and remains its life activity as far as possible；
(5) production technology of the outer product of medicine, red ginseng, aloe, Bee Pollen, bee is made by mixing in Chinese herbal medicine extract of the invention
Although glue and the vacuum freeze-drying technique of cogongrass cliff berry improve drying cost, but improve fusion and the collaboration work of effective component
With moreover, decreasing the heating time of extracting, resultant effect is much larger than the increase of drying cost；
(6) production technology of the outer product of medicine is made by mixing in Chinese herbal medicine extract of the invention, beats the freeze-drying red ginseng after powder, reed
Luxuriant growth, Bee Pollen, propolis and cogongrass cliff berry, the speed for mutually merging and extracting can be further speeded up, moreover, without adding storage
Agent, shelf-life are unaffected；
(7) production technology of the outer product of medicine is made by mixing in Chinese herbal medicine extract of the invention, is added after ginkgo leaf extracting,
Middle main component flavone compound being extracted with maximum possible, be a kind of strength platelet activating factor inhibitor,
And combined with the flavones ingredient in red ginseng, Bee Pollen, aloe, further increase skin-whitening and moisten, restore elastic effect,
Moreover, the antibacterial effect also increased, avoids exposed skin infection Escherichia coli and gold-coloured staphylococci.
Specific implementation mode
To further appreciate that present disclosure, this present invention is described in detail in conjunction with the embodiments.
Embodiment 1
The formula of the outer product of medicine, including red ginseng, aloe, Bee Pollen, bee is made by mixing in the Chinese herbal medicine extract of the present embodiment
Extraction object, surfactant, tackifier and the water of glue and cogongrass cliff berry；Surfactant, tackifier and water are respectively glycerine, seaweed
Sour sodium and deionized water.
The production technology of the outer product of medicine is made by mixing in the Chinese herbal medicine extract of the present embodiment, the specific steps are：
One, red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry are first subjected to vacuum freeze drying：
(1) it cleans：It is quiet after the soil and foreign matter on fresh red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry surface are cleaned
Set draining；
(2) it shreds：The above red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry after draining is by weight 3：3：2：1：1 matches
Shredding machine mixing chopping is transferred to after weight as by the piece or fourth of 5~10mm sizes；The process of chopping is also the process effectively mixed, and
And during chopping, the effective component of part exudation can also be merged effectively；
(3) disk is spread：Paving disk is extremely from material disc after 0.5cm or less, upper material shelf car；
(4) quick-frozen：By spread disk after material shelf car be transferred to rapidly in quick freezing repository carry out it is quick-frozen, quick freezing repository temperature require for-
34 DEG C hereinafter, 220~240 minutes quick-frozen time, can achieve the effect that puncture in the cell wall ice crystal of most of material, and incite somebody to action
Effective component carries out quick freezing type positioning；
(5) vacuum freeze drying：Semi-finished product after quick-frozen, which are transferred in vacuum freeze drying cabin, to be dried, specific dry
Process is：
A, temperature raising period：Inner panel temperature is warming up to 110~115 DEG C within 15 minutes, is evacuated to 113Pa or less；
B, distil peak period：110~115 DEG C of holding 3h of plate temperature, vacuum keep 113Pa or less；
C, the medium temperature phase：Plate temperature is cooled to 100 DEG C of holding 6.5h, and vacuum keeps 60~80Pa；
D, middle hypothermic phase：：Plate temperature is cooled to 85 DEG C of holding 2.5h, and vacuum keeps 60~80Pa；
E, the parsing-desiccation phase：Plate temperature is cooled to 65 DEG C of holding 2h, and vacuum keeps 40~60Pa；
F, hypothermic phase：Plate temperature is cooled to 55 DEG C, and the mild material temperature of plate is parallel or overlaps holding 1.5h or so rear vacuum breaker export,
Vacuum keeps 30Pa or less；
G, red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry piece or fourth must be both lyophilized after export, in drying process, moisture liter
Dryness storehouse is precipitated in China, and effective component remains in the small spaces after moisture is precipitated, and the active constituent of drug effect is retained, rehydration
With heating extractive process in and other drug effects active constituent can quickly integrated integration, can reach the effect of synergistic effect.
Two, the making of the formula of the outer product of medicine is made by mixing in Chinese herbal medicine extract：
(1) it mixes：By after vacuum freeze drying red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry piece or fourth be uniformly mixed
After be packed into non-woven bag；
(2) it heats：300 times of heavy water for adding red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry gross weight, 85~100
DEG C temperature heat 2~3 hours；
(3) it extracts：It is transferred in extractor and extracts after heating；
(4) it filters：Extract is filtered by strainer；
(5) dispensing：By filtered extract weight part be 75~80, surfactant 35~40, tackifier 15~20,
After mixing, the outer product of medicine are made by mixing in obtained Chinese herbal medicine extract to deionized water water 220~280；In the present embodiment respectively
For：Extract 75, glycerine 35, sodium alginate 15, deionized water 220.
The efficiency experimental result of the outer product of medicine is made by mixing in the present embodiment Chinese herbal medicine extract：
(1) it weighs magnesium chloride 10g to be dissolved in 100ml deionized waters, stir and evenly mix, obtain saturation magnesium chloride brine；
It weighs 30g glucose to be dissolved in 200ml deionized waters, stir and evenly mix, obtain saturation glucose solution；
(2) it takes a dry filter paper to be put into drying box and removes moisture, weighed to obtain filter weight M1 by this reality
The outer product of medicine for applying example are uniformly applied to the side of filter paper, obtain the filter paper sample 1 of the outer product of medicine of the present embodiment, are then claimed
Measure weight M2；
(3) glucose saturated aqueous solution obtained in 200ml steps (1) is poured into a drying box, it is closed, make drying
Moisture stable in case, then by the one of the outer product of painting medicine of the filter paper of the outer product of medicine of the present embodiment obtained in step (2)
On lateral, cover it is obtained in step (1) fill on the beaker of magnesium chloride saturated aqueous solution, while being by an initial weight
The filter paper of the drying of m1 covers on the beaker that another fills magnesium chloride saturated aqueous solution, and two beakers are put into drying box
Holder on, after 40 DEG C of constant temperature is placed 24 hours, weigh, obtain the weight M3 and sky that are coated with the filter paper of the outer product of medicine to be measured
The weight m2 of white filter paper；
The addition for wherein filling magnesium chloride saturated aqueous solution in the beaker of magnesium chloride saturated aqueous solution is beaker total height
30%；The shape for the filter paper stated is consistent with the shape of beaker mouth, and the shape of filter paper can just cover beaker mouth completely.
The critical relative moisture (CRH) of magnesium chloride saturated aqueous solution is 33%；The glucose saturated aqueous solution faces
Boundary's relative humidity (CRH) is 90%.
(4) the moisturizing rate of the outer product of medicine to be measured is [M3-M1-M1 × (m2-m1) ÷ m2] ÷ (M2-M1) × 100%.
In test, it can be made simultaneously in step (1) to (3) and be put into 3 groups of outer product sample samples 2 of commercially available moisturizing medicine to sample
4, it is carried out at the same time test test result, sample 1 to sample 4 is respectively 13.5%, 8.8%, 8.5%, 8.5%, and sample 2 to sample 4 is averaged
Value is 8.6%,
The moisturizing rate of sample 1 is higher by the outer product of commercially available medicine 57%.
Embodiment 2
The formula of the outer product of medicine, basic recipe and step is made by mixing with embodiment 1 in the Chinese herbal medicine extract of the present embodiment,
It thes improvement is that：Proportioning before red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry mixing is 2：3：1：2：1；
It further includes silver that Chinese herbal medicine extract, which was made by mixing in the step of the step of making of the formula of the outer product of medicine (3) extraction,
The extraction of apricot leaf extract：By ginkgo leaf in the non-woven fabrics sack, be put into circulation type and extract tank, 10 times of weights of addition 80~
After 100% alcohol, recycles 2~4 hours and extract in room temperature, harmful components are dispelled by activated carbon, then pass through 0.5~1 μm of mistake
Strainer is dispelled suspended solid and is made after ginkgo leaf extracts object, then is added into the dispensing of step (5), and additive amount is that extract is total
The 15% of weight.
In the dispensing of step (5)：Extract 80, glycerine 40, sodium alginate 20, deionized water 280；
The efficiency experimental result that the outer product of medicine are made by mixing in the present embodiment Chinese herbal medicine extract is moisturizing rate 14.1%, experiment
Process is same
Embodiment 1.
Embodiment 3
The formula of the outer product of medicine, basic recipe and step is made by mixing with embodiment 2 in the Chinese herbal medicine extract of the present embodiment,
It thes improvement is that：Proportioning is before red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry mixing：4：4：2：2：1；
The vacuum freeze-drying technique of mixture further includes step：
(6) powder is beaten：Piece or fourth that red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry mixture is lyophilized are transferred to pulverizer to beat
Aloe, Bee Pollen, the mixture of cogongrass cliff berry and ginkgo leaf after freeze-drying beat powder to 150 by powder to 150~200 mesh
After~200 mesh, then it is stripped.
Two, the making of the formula of the outer product of medicine is made by mixing in Chinese herbal medicine extract：
(1) it mixes：By after vacuum freeze drying red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry piece or fourth be uniformly mixed
After be packed into non-woven bag；
(2) it heats：300 times of red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry gross weight heavy water are added, at 85~100 DEG C
Temperature heat 60~90min；
(3) it extracts：It is transferred in extractor and extracts after heating；
(4) it filters：It is filtered to obtain red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry by strainer by extract to mix
Extract；
(5) dispensing：By filtered extract weight part be 75~80, surfactant 35~40, tackifier 15~20,
After deionized water water 220~280 mixes, adds the obtained Chinese herbal medicine extract of ionized water formation mixed liquor and be made by mixing outside medicine
Product；It is respectively in the present embodiment：Extract 78, glycerine 38, sodium alginate 18, deionized water 250.
The wherein extraction of ginkgo biloba p.e：By ginkgo leaf in non-woven fabrics sack, it is put into circulation type and extracts tank, addition
After 80~100% alcohol of 10 times of weights, recycles 1 hour and extract in room temperature, harmful components are dispelled by activated carbon, then pass through
0.5~1 μm of filter screen is dispelled suspended solid and is made after ginkgo leaf extracts object, then is added into the dispensing of step (5), additive amount
It is the 10% of extract gross weight.
Freeze-drying red ginseng, aloe, Bee Pollen, propolis and the cogongrass cliff berry after powder are beaten, the speed for mutually merging and extracting can be into
One step is accelerated.
Embodiment 4
The formula of the outer product of medicine, basic recipe and the same embodiment of step is made by mixing in the Chinese herbal medicine extract of this present embodiment
3, it thes improvement is that：Ginkgo leaf extracts again after first carrying out vacuum freeze drying.The vacuum freeze-drying technique of ginkgo leaf
Step is：
(1) it cleans：Draining is stood after fresh ginkgo leaf is cleaned；
(2) it shreds：It is piece that ginkgo leaf after draining, which is transferred to shredding machine chopping,；
(3) disk is spread：Disk is spread extremely from material disc along 0.4cm or less；
(4) quick-frozen：To spread the semi-finished product after disk be transferred in quick freezing repository carry out it is quick-frozen, quick freezing repository temperature require as -30 DEG C hereinafter,
150~180 minutes quick-frozen time；
(5) vacuum freeze drying：Semi-finished product after quick-frozen, which are transferred in vacuum freeze drying cabin, to be dried, drying curve
For：
A, temperature raising period：Inner panel temperature is warming up to 100 DEG C within 15 minutes, is evacuated to 113Pa or less；
B, distil peak period：90 DEG C of holding 4h of plate temperature drop temperature, vacuum keep 113Pa or less；
C, the medium temperature phase：Plate warm water is cold to be down to 75 DEG C of holding 6h, and vacuum keeps 60~80Pa；
D, the parsing-desiccation phase：Plate temperature is down to 65 DEG C of 1~2h of holding naturally, and vacuum keeps 40~60Pa；
E, hypothermic phase：55~60 DEG C of 1~2h of holding of plate temperature, vacuum keep 40~50Pa；
F, the short-term warming phase：Plate temperature is rapidly heated to 70~75 DEG C, and after keeping 15~30min, silver must both be lyophilized after export
Apricot leaf fragment.
It further includes ginkgo that Chinese herbal medicine extract, which was made by mixing in the step of step (3) is extracted in the production technology of the outer product of medicine,
The extraction of leaf extract：Freeze-drying ginkgo leaf fragment is mounted in non-woven fabrics sack, circulation type is put into and extracts tank, 10 times heavy of addition
After 80~100% alcohol, recycles 1 hour and extract in room temperature, harmful components are dispelled by activated carbon, then pass through 0.5~1 μm of mistake
Strainer is dispelled suspended solid and is made after ginkgo leaf extracts object, then is added into the life that the outer product of medicine are made by mixing in Chinese herbal medicine extract
In production. art in the dehydration of step (5).
The formula and its production technology of the outer product of medicine is made by mixing in the Chinese herbal medicine extract of the present embodiment, and freeze-drying ginkgo leaf is taken out
Added after carrying, wherein main component flavone compound being extracted with maximum possible, be a kind of strength platelet activation
Factor inhibitors, and combined with the flavones ingredient in red ginseng, Bee Pollen, aloe, it further increases skin-whitening and moistens, is extensive
Complex elasticity effect, moreover, the antibacterial effect also increased, avoids exposed skin infection Escherichia coli and gold-coloured staphylococci.
The efficiency experimental result that the outer product of medicine are made by mixing in the present embodiment Chinese herbal medicine extract is moisturizing rate 15.5%, experiment
Process is same
Embodiment 1.
Schematically the present invention and embodiments thereof are described above, description is not limiting.So if
Those skilled in the art are enlightened by it, without departing from the spirit of the invention, are not inventively designed
Go out frame mode similar with the technical solution and embodiment, is within the scope of protection of the invention.
Claims (8)
1. the formula of the outer product of medicine is made by mixing in a kind of Chinese herbal medicine extract, which is characterized in that including red ginseng, aloe, Bee Pollen,
Propolis and the extraction object and surfactant of cogongrass cliff berry, tackifier and water；The red ginseng, aloe, Bee Pollen, propolis and Mao Yan
The certain kind of berries carries out mixing extraction after vacuum freeze-drying technique；
Proportioning before the red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry mixing is (2~4)：(3~4)：(1~2)：(1~
2)：(1~2)；The mixed parts by weight for extracting object are 75~80, surfactant 35~40, tackifier 15~20, water 220
~280.
2. the formula of the outer product of medicine is made by mixing in Chinese herbal medicine extract as described in claim 1, which is characterized in that the surface
Activating agent and tackifier are respectively glycerine and sodium alginate；The water is deionized water.
3. the production technology of the outer product of medicine, specific steps are made by mixing in a kind of Chinese herbal medicine extract as claimed in claim 1 or 2
For：
(1) it mixes：The red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry are uniformly mixed；
(2) it heats：300 times of heavy water for adding red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry total weight, at 85~100 DEG C
Temperature heat 2~3 hours；
(3) it extracts：It is transferred in extractor and extracts after heating；
(4) it filters：Extract is filtered by strainer；
(5) it prepares：After filtered extract and surfactant, tackifier are mixed, adds ionized water and form mixed liquor
The outer product of medicine are made by mixing in obtained Chinese herbal medicine extract.
4. the production technology of the outer product of medicine is made by mixing in Chinese herbal medicine extract as claimed in claim 3, which is characterized in that described
Red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry mixture vacuum freeze-drying technique step be：
(1) it cleans：Draining is stood after fresh red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry are cleaned；
(2) it shreds：Red ginseng, aloe, Bee Pollen, propolis and cogongrass cliff berry after draining be transferred to according to the ratio shredding machine chopping be piece or
Fourth；
(3) disk is spread：Disk is spread extremely from material disc along 0.5cm or less；
(4) quick-frozen：By spread disk after semi-finished product be transferred in quick freezing repository carry out it is quick-frozen, quick freezing repository temperature require for -34 DEG C hereinafter, quick-frozen
220~240 minutes time；
(5) vacuum freeze drying：Semi-finished product after quick-frozen, which are transferred in vacuum freeze drying cabin, to be dried, and must be both lyophilized after export
Mixture tablet or fourth.
5. the production technology of the outer product of medicine is made by mixing in Chinese herbal medicine extract as claimed in claim 4, which is characterized in that described
It further include the extraction of ginkgo biloba p.e in the step of step (3) is extracted：By ginkgo leaf in non-woven fabrics sack, it is put into circulation
Formula extracts tank, after 80~100% alcohol for adding 12 times of weights, recycles 3~4 hours and extracts in room temperature, dispelled by activated carbon
Harmful components, then by 0.5~1 μm of filter screen dispels suspended solid after obtained ginkgo leaf extraction object, then it is added into step (5)
Preparation in.
6. the production technology of the outer product of medicine is made by mixing in Chinese herbal medicine extract as claimed in claim 5, which is characterized in that described
Ginkgo leaf extracts again after first carrying out vacuum freeze drying.
7. the production technology of the outer product of medicine is made by mixing in Chinese herbal medicine extract as claimed in claim 6, which is characterized in that described
The vacuum freeze-drying technique step of ginkgo leaf is：
(1) it cleans：Draining is stood after fresh ginkgo leaf is cleaned；
(2) it shreds：It is piece that ginkgo leaf after draining, which is transferred to shredding machine chopping,；
(3) disk is spread：Disk is spread extremely from material disc along 0.4cm or less；
(4) quick-frozen：By spread disk after semi-finished product be transferred in quick freezing repository carry out it is quick-frozen, quick freezing repository temperature require for -33 DEG C hereinafter, quick-frozen
200~220 minutes time；
(5) vacuum freeze drying：Semi-finished product after quick-frozen, which are transferred in vacuum freeze drying cabin, to be dried, and must be both lyophilized after export
Powder is beaten after ginkgo leaf fragment.
8. the production technology of the outer product of medicine is made by mixing in Chinese herbal medicine extract as claimed in claim 7, which is characterized in that described
The temperature curve of step (5) vacuum freeze drying is：
A, temperature raising period：Inner panel temperature is warming up to 100 DEG C within 15 minutes, is evacuated to 113Pa or less；
B, distil peak period：90 DEG C of holding 4h of plate temperature drop temperature, vacuum keep 113Pa or less；
C, the medium temperature phase：Plate warm water is cold to be down to 75 DEG C of holding 6h, and vacuum keeps 60~80Pa；
D, the parsing-desiccation phase：Plate temperature is down to 65 DEG C of 1~2h of holding naturally, and vacuum keeps 40~60Pa；
E, hypothermic phase：55~60 DEG C of 1~2h of holding of plate temperature, vacuum keep 40~50Pa；
F, the short-term warming phase：Plate temperature is rapidly heated to 70~75 DEG C, and after keeping 15~30min, ginkgo leaf must both be lyophilized after export
Fragment.
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