CN108378366A - The preparation method of relieving alcoholism and protecting liver formula, electuary and beverage - Google Patents
The preparation method of relieving alcoholism and protecting liver formula, electuary and beverage Download PDFInfo
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- CN108378366A CN108378366A CN201810077101.7A CN201810077101A CN108378366A CN 108378366 A CN108378366 A CN 108378366A CN 201810077101 A CN201810077101 A CN 201810077101A CN 108378366 A CN108378366 A CN 108378366A
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- 210000004185 liver Anatomy 0.000 title claims abstract description 62
- 208000007848 Alcoholism Diseases 0.000 title claims abstract description 44
- 201000007930 alcohol dependence Diseases 0.000 title claims abstract description 44
- 235000013361 beverage Nutrition 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 52
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims abstract description 32
- 239000002994 raw material Substances 0.000 claims abstract description 24
- 244000269722 Thea sinensis Species 0.000 claims abstract description 22
- 235000006468 Thea sinensis Nutrition 0.000 claims abstract description 20
- 235000020279 black tea Nutrition 0.000 claims abstract description 20
- 230000000694 effects Effects 0.000 claims abstract description 20
- 235000012754 curcumin Nutrition 0.000 claims abstract description 16
- 229940109262 curcumin Drugs 0.000 claims abstract description 16
- 239000004148 curcumin Substances 0.000 claims abstract description 16
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims abstract description 16
- 108010038807 Oligopeptides Proteins 0.000 claims abstract description 14
- 102000015636 Oligopeptides Human genes 0.000 claims abstract description 14
- 240000008042 Zea mays Species 0.000 claims abstract description 14
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 claims abstract description 14
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims abstract description 14
- 235000009973 maize Nutrition 0.000 claims abstract description 14
- 230000002075 anti-alcohol Effects 0.000 claims description 21
- 244000046146 Pueraria lobata Species 0.000 claims description 9
- 235000010575 Pueraria lobata Nutrition 0.000 claims description 9
- 235000008422 Schisandra chinensis Nutrition 0.000 claims description 8
- 240000006365 Vitis vinifera Species 0.000 claims description 6
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 6
- 240000006079 Schisandra chinensis Species 0.000 claims description 4
- 238000001802 infusion Methods 0.000 claims description 4
- YEFOAORQXAOVJQ-RZFZLAGVSA-N schisandrol a Chemical compound C1[C@H](C)[C@@](C)(O)CC2=CC(OC)=C(OC)C(OC)=C2C2=C1C=C(OC)C(OC)=C2OC YEFOAORQXAOVJQ-RZFZLAGVSA-N 0.000 claims description 4
- 229930186938 hovenoside Natural products 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 229930193195 schizandrin Natural products 0.000 claims description 2
- 238000012859 sterile filling Methods 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 235000013616 tea Nutrition 0.000 claims description 2
- YEFOAORQXAOVJQ-UHFFFAOYSA-N wuweizischun A Natural products C1C(C)C(C)(O)CC2=CC(OC)=C(OC)C(OC)=C2C2=C1C=C(OC)C(OC)=C2OC YEFOAORQXAOVJQ-UHFFFAOYSA-N 0.000 claims description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 230000036541 health Effects 0.000 abstract description 5
- 235000019441 ethanol Nutrition 0.000 description 31
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 20
- 241000699666 Mus <mouse, genus> Species 0.000 description 19
- 241000699670 Mus sp. Species 0.000 description 19
- 238000003304 gavage Methods 0.000 description 17
- 230000000052 comparative effect Effects 0.000 description 16
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 14
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 14
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 12
- 239000008280 blood Substances 0.000 description 12
- 238000002474 experimental method Methods 0.000 description 12
- 239000007788 liquid Substances 0.000 description 12
- 239000008188 pellet Substances 0.000 description 12
- 239000007787 solid Substances 0.000 description 12
- 230000001154 acute effect Effects 0.000 description 8
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- 108010024636 Glutathione Proteins 0.000 description 6
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- 239000000243 solution Substances 0.000 description 6
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- 238000000034 method Methods 0.000 description 5
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 241000736075 Schisandra Species 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 239000002504 physiological saline solution Substances 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 239000008187 granular material Substances 0.000 description 3
- 210000005229 liver cell Anatomy 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 235000015096 spirit Nutrition 0.000 description 3
- 235000020097 white wine Nutrition 0.000 description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000002158 endotoxin Substances 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
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- 238000007619 statistical method Methods 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 235000014101 wine Nutrition 0.000 description 2
- 206010003084 Areflexia Diseases 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
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- 238000001727 in vivo Methods 0.000 description 1
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- 230000002757 inflammatory effect Effects 0.000 description 1
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- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
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- 230000004792 oxidative damage Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
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- 230000002265 prevention Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses the preparation methods of a kind of relieving alcoholism and protecting liver formula, electuary and beverage.The raw material of relieving alcoholism and protecting liver formula includes by mass fraction：1 to 40 part of maize oligopeptide, 7 to 8 parts of black tea extract, 0.1 to 0.2 part of curcumin, the ratio between the black tea extract and the curcumin are 35 to 80.The effect of in relieving alcoholism and protecting liver formula provided by the invention, mainly being relieved the effect of alcohol to human body using maize oligopeptide, black tea extract and curcumin, good protect liver and protection health can be played while playing good dispelling effects of alcohol.
Description
Technical field
The present invention relates to the field of relieving the effect of alcohol, especially a kind of relieving alcoholism and protecting liver formula, infusion for relieving alcoholism and protecting liver preparation method and
The preparation method of anti-alcohol and liver-protection beverage.
Background technology
China is the consumption big country of all kinds of wine products, and Characters of Chinese Alcoholic Drink Culture is of long standing and well established, but body can be caused by drinking beyond one's capacity
The uncomfortable even acute alcoholism of various physiology, long-term excessive consumption of alcohol endanger risk exacerbation.As the important solution of human body after drinking
Malicious organ, the catabolism of ethyl alcohol are carried out in vivo in a manner of liver internal oxidition.Heavy drinking or long-term excessive drink
Wine is well over liver eubolism ability, ethyl alcohol is caused largely to be accumulated in blood and liver.The ethyl alcohol accumulated in liver is straight
It connects stimulation tissue and generates endotoxin, endotoxin stimulates liver cell to generate a large amount of inflammatory factor, directly causes liver cell scorching
The even necrosis of disease, liver cell anoxic.
In view of the above-mentioned problems, propose some anti-alcohol and liver-protection beverages in the prior art, mainly by a large amount of pueraria lobata,
The Chinese herbal medicines such as hoveniae semoveniae semen, Schisandra chinensis relieve the effect of alcohol, it has been found that carrying out solution cocktail party using a large amount of Chinese herbal medicine inhibits acetaldehyde
The activity of dehydrogenase, to increase the risk that drinking person suffers from acetaldehyde related neoplasms.
Invention content
It can effectively relieve the effect of alcohol in view of this, an object of the present invention is to provide one kind and ensure user's health
Relieving alcoholism and protecting liver formula, infusion for relieving alcoholism and protecting liver and beverage preparation method.
In order to achieve the above object, on the one hand, the present invention adopts the following technical scheme that：
A kind of relieving alcoholism and protecting liver formula, the raw material of the formula include by mass fraction：
1 to 40 part of maize oligopeptide
7 to 8 parts of black tea extract
0.1 to 0.2 part of curcumin
Wherein, the ratio between the black tea extract and the curcumin are 35 to 80.
For example, maize oligopeptide is 1 part, 5 parts, 10 parts, 13 parts, 20 parts, 30 parts, 35 parts, 37 parts, 39 parts, 40 parts.
Black tea extract is 7 parts, 7.2 parts, 7.5 parts, 7.8 parts, 8 parts.
Curcumin is 0.1 part, 0.12 part, 0.15 part, 0.17 part, 0.2 part.
Preferably, the black tea extract includes the tea polyphenols of black tea.
Preferably, the maize oligopeptide is 35 to 40 parts.
Preferably, the raw material of the formula further includes by mass fraction：
5 to 60 parts of oligofructose.
For example, oligofructose be 5 parts, 10 parts, 17 parts, 20 parts, 30 parts, 35 parts, 40 parts, 42 parts, 45 parts, 48 parts, 50
Part.
Preferably, the oligofructose is 40 to 50 parts.
Preferably, the raw material of the formula further includes by mass fraction：
1 to 30 part of kudzu root extract
0.5 to 10 part of raisin tree seed extract
0.1 to 12 part of Schisandra chinens P.E
0.5 to 5 part of vitamin C.
Such as kudzu root extract is 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 10 parts, 15 parts, 20 parts, 27 parts, 30 parts.
Raisin tree seed extract is 0.5 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 8 parts, 10 parts.
Schisandra chinens P.E is 0.1 part, 0.5 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 10 parts, 12 parts.
Vitamin C is 0.5 part, 0.7 part, 1 part, 3 parts, 5 parts.
Preferably, the kudzu root extract is 3 to 5 parts；And/or
The raisin tree seed extract is 1 to 5 part；And/or
The Schisandra chinens P.E is 1 to 5 part.
Preferably, the kudzu root extract includes pueraria isoflavone；And/or
The raisin tree seed extract includes hovenoside；And/or
The Schisandra chinens P.E includes schizandrin.
On the other hand, the present invention adopts the following technical scheme that：
A kind of preparation method of infusion for relieving alcoholism and protecting liver, using relieving alcoholism and protecting liver formula as described above, the preparation method packet
It includes：
Raw material is mixed, it is preferable that mix powder raw material；
It is granulated, it is preferable that granulated mixed powder raw material using granule producing machine；
It is dry, it is preferable that the granule granule of granulating is dried；
It weighs；
Packaging.
In another aspect, the present invention adopts the following technical scheme that：
A kind of preparation method of anti-alcohol and liver-protection beverage, using relieving alcoholism and protecting liver formula as described above, the preparation method packet
It includes：
Raw material is mixed；
Dissolving obtains solution；
Tubular type centrifugal treating is carried out to solution；
Sterilization；
Sterile filling.
In relieving alcoholism and protecting liver formula provided by the invention, maize oligopeptide, black tea extract and curcumin pair are mainly utilized
Human body relieves the effect of alcohol, and good protect liver can be played while playing good dispelling effects of alcohol and protects health
Effect.
Specific implementation mode
Below based on embodiment, present invention is described, but the present invention is not restricted to these embodiments.In order to
The essence for the present invention that avoids confusion, there is no narrations in detail for well known method, process, flow, element.
Unless the context clearly requires otherwise, "include", "comprise" otherwise throughout the specification and claims etc. are similar
Word should be construed as the meaning for including rather than exclusive or exhaustive meaning；That is, being containing for " including but not limited to "
Justice.
In the description of the present invention, it is to be understood that, term " first ", " second " etc. are used for description purposes only, without
It can be interpreted as indicating or implying relative importance.In addition, in the description of the present invention, unless otherwise indicated, the meaning of " multiple "
It is two or more.
Embodiment one：
The raw material of relieving alcoholism and protecting liver formula provided in this embodiment includes by mass fraction：
1 part of maize oligopeptide
7 parts of black tea extract
0.2 part of curcumin
Embodiment two：
The raw material of relieving alcoholism and protecting liver formula provided in this embodiment includes by mass fraction：
35 parts of maize oligopeptide
7.5 parts of black tea extract
0.1 part of curcumin
Embodiment three：
The raw material of relieving alcoholism and protecting liver formula provided in this embodiment includes by mass fraction：
38 parts of maize oligopeptide
7.7 parts of black tea extract
0.15 part of curcumin
Example IV：
The raw material of relieving alcoholism and protecting liver formula provided in this embodiment includes by mass fraction：
40 parts of maize oligopeptide
8 parts of black tea extract
0.18 part of curcumin
Embodiment five：
The raw material of relieving alcoholism and protecting liver formula provided in this embodiment includes by mass fraction：
Embodiment six：
The raw material of relieving alcoholism and protecting liver formula provided in this embodiment includes by mass fraction：
Embodiment seven：
The raw material of relieving alcoholism and protecting liver formula provided in this embodiment includes by mass fraction：
Embodiment eight：
The raw material of relieving alcoholism and protecting liver formula provided in this embodiment includes by mass fraction：
Comparative example one：
The raw material of this comparative example includes by mass fraction：
35 parts of maize oligopeptide
7 parts of black tea extract
8 parts of curcumin
Comparative example two：
The raw material of this comparative example includes by mass fraction：
35 parts of maize oligopeptide
0.1 part of black tea extract
0.2 part of curcumin
Experimental verification：
1 materials and methods
1.1 materials, reagent and instrument
Under the same conditions respectively according to embodiment one to eight and comparative example one and two be formulated, above-mentioned beverage
Preparation method and electuary preparation method prepare liquid beverage and solid pellet respectively, and solid pellet is dissolved in the water so that
The content all same of raw material after preparation in each embodiment and comparative example.
Healthy Swiss male mices, weight (22 ± 3) g are purchased from Beijing Vital River Experimental Animals Technology Co., Ltd.,
Experiment is mouse special feed with feed.
Alcohol dehydrogenase (ADH), malonaldehyde (MDA), reductive glutathione (GSH) kit, are purchased from Nanjing and build up
Bioengineering Research Institute；
52 ° of cattle pen mountain board fen-flavor type white spirits, Beijing Shunxin Agriculture Co., Ltd. Niulanshan Winery；
Electronic balance BT25S (German Sai Duolisi)；
High performance liquid chromatograph LaChromElite (Tian Mei Science and Technology Ltd.s)；
Enzyme-linked immunosorbent assay instrument ELx800 (U.S. biotek).
1.2 method
1.2.1 mice drunk dosage experiments
40 health Swiss male mices are randomly divided into 4 groups, every group 10.Fasting 12h, free water before experiment.
It is respectively 52 ° of clear type white wine pair of cattle pen mountain board of 0.20mL, 0.30mL, 0.35mL, 0.4mL by every 20g weight dosage when experiment
Mouse carries out gavage.Using mouse righting reflex loss (30s is standard) be drunk judgement standard, and observe and record mouse from
Gavage to it is drunk when the time required to.
1.2.2 anti-alcohol and liver-protection beverage antialcoholism function is tested
525 health Swiss male mices are randomly divided into model control group, one to eight liquid beverage group of embodiment, right
Ratio one and two liquid beverage groups, one to eight solid pellet group of embodiment, comparative example one and two solid pellet groups, totally 21 groups, often
Group 25；5 groups of a, b, c, d, e are randomly divided by every group again, per group 5.
The experiment mice of model control group press 0.3mL/20g gavage physiological saline, one to eight liquid beverage group of embodiment with
And the experiment mice of comparative example one and two liquid beverage groups press 0.3mL/20g gavage relieving alcoholism and protecting liver liquid beverages, embodiment one to
The experiment mice of eight solid pellet groups and comparative example one and two solid pellet groups presses 0.3mL/20g gavage relieving alcoholism and protecting liver solid-states
Pellet solution, the 52 ° of cattle pen mountain board fen-flavor type white spirits of mice drunk dosage gavage determined according to 1.2.1 after gavage 30min.
Feed after white wine 20min, 40min, 80min, 160min respectively by 5 mouse of group a, b, c, d, e pluck eyeball take blood in
In 2mL centrifuge tubes, anti-coagulants, 37 DEG C of constant temperature is added to stand 15min, then 3000r/min centrifuges 15min, obtains serum.According to blood
The requirement of clear alcohol determining kit (Bioengineering Research Institute is built up in Nanjing) measures mice serum with automatic clinical chemistry analyzer
In ethanol content.The difference of comparative experiments group and control group ethanol in blood mass concentration.
1.2.3 anti-alcohol and liver-protection beverage liver-protecting function is tested
220 health Swiss male mices are randomly divided into 22 groups：Blank control group, model control group, embodiment one
It is solid to eight liquid beverage groups, comparative example one and two liquid beverage groups, one to eight solid pellet group of embodiment, comparative example one and two
State pellet group, every group 10.The physiological saline of blank control group gavage 0.3mL/20g, model control group gavage 0.3mL/20g
Physiological saline, one to eight liquid beverage group of embodiment, comparative example one and two liquid beverage group gavage 0.3mL/20g relieve the effect of alcohol shield
Liver liquid beverage, one to eight solid pellet group of embodiment, comparative example one and two solid pellet group gavage 0.3mL relieving alcoholism and protecting livers are solid
State pellet solution gives 52 ° of cattle pen mountain board fen-flavor type white spirits of each experimental group gavage 0.3mL/20g, blank control group after 30min again
Gavage physiological saline.After continuous gavage 30d, fasting 12h takes liver that homogenate is made, and then builds up bioengineering according to Nanjing and grinds
Study carefully institute's kit to require to measure alcohol dehydrogenase (ADH), malonaldehyde (MDA), reduced glutathione (GSH) in mouse liver
Content, the difference of comparative analysis each group content.
1.3 statistical procedures
All data are for statistical analysis using SPSS19.0, and data information is indicated using mean ± standard deviation (X ± S),
Each Indexes Comparison uses independent samples t test method between experimental group, is with significant difference with P ＜ 0.05.
2 results
2.1 mouse models prepare result
As can be seen from Table 1, mouse that vina amount is 0.2mL is filled per 20g without drunk phenomenon, and remaining 4 groups have it is bright
Aobvious drunk phenomenon occurs.It is respectively two groups of 0.35mL, 0.40mL to fill vina amount, and drunk rate is up to 100% and ratio of drunk time
It is shorter, but the death rate is relatively high, respectively up to 40% and 60%.In contrast, it is the most suitable of mouse that vina amount 0.3mL is filled per 20g
Close the drunk dosage of acute alcoholism.
Experiment mice performance (n=10) under the different given lows of table 1
The antialcoholism function of 2.2 anti-alcohol and liver-protection beverages
After gavage 52 ° of cattle pen mountains board fen-flavor type white spirit 20min, 40min, 80min, 160min, the ethyl alcohol in mouse blood
Mass concentration testing result is shown in Table 2, and compared with model control group, anti-alcohol and liver-protection beverage reduces ethyl alcohol in mouse blood and contains
The effect of amount is fairly obvious.Statistical analysis show anti-alcohol and liver-protection beverage experimental group and model control group fill after drinking 20min,
The difference of the alcohol levels in blood samples mass concentration of 40min, 80min, 160min reaches the level of signifiance (P<0.05), each group mouse is equal
When filling 80min after drinking, alcohol levels in blood samples mass concentration reaches maximum value, and the second in anti-alcohol and liver-protection beverage experimental mice blood
Alcohol mass concentration is in low-level always.The anti-alcohol and liver-protection beverage experimental mice ethanol in blood mass concentration in 160min
8g/L or so and 6g/L or so are dropped to respectively, and saline control group illustrates anti-alcohol and liver-protection beverage to drop in 19g/L or more
The effect of ethyl alcohol mass concentration is apparent in mouse blood after low acute alcoholism, and anti-alcohol and liver-protection beverage can promote alcohol generation
It thanks.In addition, comparative example one and comparative example two have adjusted black tea extract and curcumin relative to embodiment one to example IV
Content and ratio, although (i.e. 20min) can inhibit the concentration of alcohol in serum in the early stage, follow-up inhibition concentration of alcohol
Effect is deteriorated.
2 each processing group acute alcoholism experiment mice concentration of ethanol in serum (g/L, n=10) of table
The liver-protecting function of 2.3 anti-alcohol and liver-protection beverages
Alcohol dehydrogenase (ADH) vigor in mouse liver homogenate after continuous gavage 30d, malonaldehyde (MDA) content and also
Prototype glutathione (GSH) measurement result is shown in Table 3, after continuous gavage 30d white wine, model control group and blank control group
It compares, alcohol dehydrogenase (ADH) vigor significantly reduces, and malonaldehyde (MDA) content dramatically increases, reduced glutathione (GSH)
It significantly reduces, illustrates that chmice acute alcoholism model is successfully prepared.Compared with model control group, anti-alcohol and liver-protection beverage experiment
Group mouse liver in alcohol dehydrogenase (ADH) vigor significantly increase (P ＜ 0.05=, illustrate that anti-alcohol and liver-protection beverage can be carried obviously
The activity of alcohol dehydrogenase (ADH) in high mouse liver is conducive to the catabolism of alcohol in liver, mitigates Mice Hepatocytes Injured by Ethanol
The injury of liver organization function.Malonaldehyde (MDA) in model control group mouse liver is significantly higher than other three groups of (P<
0.05) malonaldehyde (MDA) content, and in relieving alcoholism and protecting liver solid beverage experimental mice liver is minimum.This shows shield of relieving the effect of alcohol
Liver beverage can be substantially reduced the level of the malonaldehyde (MDA) in mouse liver, play a protective role to mouse liver.With model
Control group is compared, the content apparent increase (P of reduced glutathione (GSH) in anti-alcohol and liver-protection beverage group mouse liver<
0.05), illustrate that anti-alcohol and liver-protection beverage can reduce liver oxidation emergency level, reduce the consumption of reduced glutathione (GSH),
Protect liver.In addition, by embodiment five it is found that when pueraria lobata, hoveniae semoveniae semen, these traditional Chinese medicine ingredients too high levels of Schisandra chinensis, second
Alcohol dehydrogenase (ADH) vigor is significantly reduced compared to the lower embodiment of other traditional Chinese medicine ingredients contents.
3 anti-alcohol and liver-protection beverage of table is to acute alcoholism experiment mice liver protection effect Indexs measure result (n=10)
Anti-alcohol and liver-protection beverage provided by the present application to acute alcoholism mice prevention the result shows that：Relieving alcoholism and protecting liver
Beverage has apparent preventive effect of relieving the effect of alcohol to acute alcoholism mice, can effectively reduce alcohol absorption and enter blood, promote alcohol
The effect of metabolism.Anti-alcohol and liver-protection beverage has the function of reducing ethyl alcohol to liver oxidative damage.
Those skilled in the art will readily recognize that under the premise of not conflicting, above-mentioned each preferred embodiment can be free
Ground combination, superposition.
It should be appreciated that above-mentioned embodiment is merely exemplary, and not restrictive, in the base without departing from the present invention
In the case of present principles, those skilled in the art can be directed to the various apparent or equivalent modification that above-mentioned details is made
Or replace, all it is included in scope of the presently claimed invention.
Claims (10)
1. a kind of relieving alcoholism and protecting liver formula, which is characterized in that the raw material of the formula includes by mass fraction：
1 to 40 part of maize oligopeptide
7 to 8 parts of black tea extract
0.1 to 0.2 part of curcumin
Wherein, the ratio between the black tea extract and the curcumin are 35 to 80.
2. relieving alcoholism and protecting liver formula according to claim 1, which is characterized in that the black tea extract includes that the tea of black tea is more
Phenol.
3. relieving alcoholism and protecting liver formula according to claim 1, which is characterized in that the maize oligopeptide is 35 to 40 parts.
4. the relieving alcoholism and protecting liver formula according to one of claims 1 to 3, which is characterized in that the raw material of the formula presses quality
Number further includes：
5 to 60 parts of oligofructose.
5. relieving alcoholism and protecting liver formula according to claim 4, which is characterized in that the oligofructose is 40 to 50 parts.
6. the relieving alcoholism and protecting liver formula according to one of claims 1 to 3, which is characterized in that the raw material of the formula presses quality
Number further includes：
7. relieving alcoholism and protecting liver formula according to claim 6, which is characterized in that the kudzu root extract is 3 to 5 parts；With/
Or,
The raisin tree seed extract is 1 to 5 part；And/or
The Schisandra chinens P.E is 1 to 5 part.
8. relieving alcoholism and protecting liver formula according to claim 7, which is characterized in that the kudzu root extract includes the different Huang of pueraria lobata
Ketone；And/or
The raisin tree seed extract includes hovenoside；And/or
The Schisandra chinens P.E includes schizandrin.
9. a kind of preparation method of infusion for relieving alcoholism and protecting liver, which is characterized in that use relieving the effect of alcohol as described in one of claim 1 to 8
Protect liver formula, the preparation method include：
Raw material is mixed；
It is granulated；
It is dry；
It weighs；
Packaging.
10. a kind of preparation method of anti-alcohol and liver-protection beverage, which is characterized in that use relieving the effect of alcohol as described in one of claim 1 to 8
Protect liver formula, the preparation method include：
Raw material is mixed；
Dissolving obtains solution；
Tubular type centrifugal treating is carried out to solution；
Sterilization；
Sterile filling.
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| CN109007808A (en) * | 2018-08-14 | 2018-12-18 | 宝健（北京）生物技术有限公司 | A kind of relieving alcoholism and protecting liver composition and the relieving alcoholism and protecting liver preparation comprising it |
| CN109329685A (en) * | 2018-12-10 | 2019-02-15 | 陈爱梅 | A kind of anti-alcohol and liver-protection beverage and preparation method thereof |
| CN109432386A (en) * | 2018-11-08 | 2019-03-08 | 武汉森澜生物科技有限公司 | A kind of corn peptide combinations of relieving alcoholism and protecting liver and preparation method thereof |
| CN110226687A (en) * | 2019-06-12 | 2019-09-13 | 宁波依萃健生物科技有限公司 | A kind of relieving alcoholism and protecting liver composition and preparation method |
| CN112167635A (en) * | 2020-09-27 | 2021-01-05 | 北京君威天健生物科技有限公司 | Alcohol-dispelling and liver-protecting sustained-release microcapsule and preparation method thereof |
| CN114767826A (en) * | 2022-04-01 | 2022-07-22 | 河北科技大学 | Sobering-up and liver-protecting composition, beverage with sobering-up and liver-protecting effects and preparation method of beverage |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109007808A (en) * | 2018-08-14 | 2018-12-18 | 宝健（北京）生物技术有限公司 | A kind of relieving alcoholism and protecting liver composition and the relieving alcoholism and protecting liver preparation comprising it |
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| CN112167635A (en) * | 2020-09-27 | 2021-01-05 | 北京君威天健生物科技有限公司 | Alcohol-dispelling and liver-protecting sustained-release microcapsule and preparation method thereof |
| CN114767826A (en) * | 2022-04-01 | 2022-07-22 | 河北科技大学 | Sobering-up and liver-protecting composition, beverage with sobering-up and liver-protecting effects and preparation method of beverage |
| CN114767826B (en) * | 2022-04-01 | 2024-04-12 | 成都润馨堂药业有限公司 | Sobering-up liver-protecting composition, beverage with sobering-up liver-protecting efficacy and preparation method thereof |
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