CN107184891A - A kind of sobering-up composition, preparation method and evaluation method - Google Patents
A kind of sobering-up composition, preparation method and evaluation method Download PDFInfo
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- CN107184891A CN107184891A CN201710349333.9A CN201710349333A CN107184891A CN 107184891 A CN107184891 A CN 107184891A CN 201710349333 A CN201710349333 A CN 201710349333A CN 107184891 A CN107184891 A CN 107184891A
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
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- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
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Abstract
The present invention provides a kind of sobering-up composition, including the root of kudzu vine, flower of kudzuvine, radix glycyrrhizae, fructus amomi, rhizome of cyrtomium, chrysanthemum, honey, hoveniae semoveniae semen, rhizoma imperatae, peppermint are made；Preparation method, including：Chinese herbal medicine pretreatment, extraction, purification；The evaluation method of wine composition：Determine influence, the influence for situation of being relieved the effect of alcohol to mouse of drinking, the influence to the anti-intoxication situation of mouse of drinking, the influence that ataxia situation is corrected to mouse of drinking of the alcohol gavage amount, modeling, detection of drunk mouse to mice serum ALT, AST；A kind of chewing gum contains sobering-up composition 10% 20%, and remaining is matrix and flavouring；The sobering-up composition of the present invention and its chewing gum being made, with good antialcoholism function, can be verified by the evaluation system of system.
Description
Technical field
The present invention relates to a kind of composition with special efficacy, more particularly to a kind of sobering-up composition, preparation method and
Evaluation method.
Background technology
China is the native place of wine, is also the cradle of spirits culture, is one of earliest country of making wine in the world.The wine of wine
Make, in the existing suitable long history of China.In Chinese thousands of years development of civilization history, the development of wine and culture is substantially
Synchronous progress.If drink in appropriate amount, and somewhat good dish, happy, it is benefit often to change evil, receives pennies from heaven.
Drink low wine has positive effect to prevention of cardiovascular disease on a small quantity；It is long-term largely to drink strong drink then to health danger
Evil is very big, excessive consumption of alcohol to the harm of all multisystems such as digestion, nervous centralis, reproduction and may be brought by drinking it is a series of
The problems such as traffic, society.
In addition to the immediacy influence (being commonly called as to be drunk) caused by once drinking beyond one's capacity, continuous heavy drinking meeting again and again
A variety of serious chronicity diseases are caused, injury of the excessive consumption of alcohol to the liver and stomach of human body is huge：Often drink beyond one's capacity to liver
Dirty harm is maximum, and poisoning can allow liver organization downright bad because of anoxic caused by heavy drinking in the short time.Long-term heavy drinking
Alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis etc. can be triggered.Alcohol can make the excessive hydrochloric acid in gastric juice of stomach lining secretion.Greatly
After amount is drunk, gastric epithelial cells are damaged, and are induced mucosa edema, bleeding, or even ulcer, erosion, are caused gastrorrhagia.Therefore have
Antialcoholism function product commercially has very big demand.
The content of the invention
It is an object of the invention to provide a kind of sobering-up composition, preparation method and evaluation method for present invention offer.
To achieve these goals, the present invention provides following technical scheme：
A kind of sobering-up composition, including following raw material composition：12-18 parts of the root of kudzu vine, 12-18 parts of flower of kudzuvine, radix glycyrrhizae 12-
18 parts, 12-18 parts of fructus amomi, 12-18 parts of rhizome of cyrtomium, 12-18 parts of chrysanthemum, 12-18 parts of honey, 12-18 parts of hoveniae semoveniae semen, rhizoma imperatae 12-
18 parts, 12-18 parts of peppermint is made；
A kind of preparation method of sobering-up composition, comprises the following steps：
1), Chinese herbal medicine is pre-processed：
First by the root of kudzu vine, flower of kudzuvine, radix glycyrrhizae, fructus amomi, rhizome of cyrtomium, chrysanthemum, hoveniae semoveniae semen, rhizoma imperatae, 90 DEG C in an oven of peppermint difference
Under the conditions of dry 2h, then the Chinese herbal medicine of drying is crushed with pulverizer respectively, the powder after crushing uniformly mixed, in obtaining
Herbal powder；
2), the extraction of Chinese herbal medicine effective ingredientses：
Herbal powder is taken, it is backflow extraction 2h in 40% ethanol solution to be added to the concentration of 10 times of amounts, controls temperature
70-75 DEG C, suction filtration obtains filtrate A；Filter residue is extracted once with condition, obtains liquor B, the above-mentioned filtrate A and B being collected into is merged, 75
No ethanol flavor is concentrated under reduced pressure at DEG C, no alcohol leaching liquor is obtained；
3), the purifying of Chinese herbal medicine leaching liquor：
Gained is added into medical decoloration active carbon, 50-55 DEG C of heating 10min, decolouring removal of impurities without alcohol leaching liquor；Suction filtration repeatedly
Untill substantially transparent, honey is added, sobering-up composition is obtained.
A kind of evaluation method of sobering-up composition, comprises the following steps：
1) the modeling condition of drunk model is determined：
Influence of the various dose alcohol gavage to mouse is investigated, the experiment white wine gavage amount of drunk mouse is determined；
Take small white mouse 100, male and female half and half, random packet, every group 10, fasting 12h before experiment, progress ethanol-tolerant examination
Test, using the preferable white wine G of commercially available sales volume, do alcohol gavage according to 0.10ml/10g~0.20ml/10g body weight gavage amounts real
Test, according to experimental result, determine the experiment white wine gavage amount X of drunk mouse, the standard of determination is：Mouse is most of drunk, revival
Quantity is relatively more, and the death rate is relatively fewer；
2) evaluation experimental：
A. influence experiment of the sobering-up composition to mice serum ALT, AST：
Healthy mice 60 is taken, body weight 18-22g, male and female half and half are raised one week, stochastic averagina is divided into 6 by adaptability
Group；It is each in experiment if normal group, model group, positive controls, low dosage experimental group, middle dosage experimental group, high dose experimental group
Fasting 12h before group animal experiment, normal group is normally fed, without white wine gavage, and remaining 5 groups are gavaged by X white wine gavage amount
Modeling, after modeling terminates, model group is without any processing, and positive controls are gavaged with sea Wang Jin cups 0.3ml/10g, and low dosage is real
Test that group is gavaged with sobering-up composition 0.1ml/10g, middle dosage experimental group is gavaged with sobering-up composition 0.3ml/10g, high dose it is real
Group is tested to be gavaged with sobering-up composition 0.6ml/10g；After gavaging administration one hour, in 6 groups of mouse socket of the eye arteries and socket of the eye venous blood sampling, take
Virus monitory mice serum ALT, AST, investigate influence of the sobering-up composition to mice serum ALT, AST；
B. sobering-up composition relieves the effect of alcohol the influence of situation to mouse of drinking：
Healthy mice 30 is taken, body weight 18-22g, male and female half and half are raised one week, stochastic averagina is divided into 3 by adaptability
Group；If tested material group A, tested material group B and placebo, fasting 12h before each group animal experiment in experiment, 30 mouse are by X's
White wine gavage amount gavages modeling, after modeling terminates, and tested material group A is gavaged with sobering-up composition 0.3ml/10g, and tested material group B is used
Sobering-up composition 0.6ml/10g is gavaged, and placebo is gavaged with pure water 0.1ml/10g；Record tested material group A, tested material group
B and placebo are averagely sobered up the time, compare the difference existed between placebo and tested material group A, B, investigate sobering-up composition
The influence for situation of being relieved the effect of alcohol to mouse of drinking；
C. influence of the sobering-up composition to the anti-intoxication situation of mouse of drinking：
Healthy mice 30 is taken, body weight 18-22g, male and female half and half are raised one week, stochastic averagina is divided into 3 by adaptability
Group；If tested material group C, tested material group D and placebo, fasting 12h before each group animal experiment in experiment, afterwards, tested material group C
Gavaged with sobering-up composition 0.3ml/10g, tested material group D is gavaged with sobering-up composition 0.6ml/10g, placebo is with pure
Water 0.1ml/10g is gavaged, and is gavaged after 10min, and 30 mouse are gavaged by X white wine gavage amount, gavages after end, records tested
Thing group C, tested material group D and placebo are averagely sobered up the time, compare the difference existed between placebo and tested material group C, D,
Investigate influence of the sobering-up composition to the anti-intoxication situation of mouse of drinking；
D. sobering-up composition corrects the influence of ataxia situation to mouse of drinking；
Healthy mice 30, body weight 18-22g, male and female half and half are raised one week, stochastic averagina is divided into 3 groups by adaptability；
If tested material group E, tested material group F and placebo, fasting 12h before each group animal experiment in experiment, 30 mouse press X white wine
Gavage amount gavages modeling, after modeling terminates, and tested material group E is gavaged with sobering-up composition 0.3ml/10g, and tested material group F is with relieving the effect of alcohol
Composition 0.6ml/10g is gavaged, and placebo is gavaged with pure water 0.1ml/10g；After 10min, all mouse are placed on vertically
That hangs is online, and record mouse is in online residence time, and observation sobering-up composition is caused after drinking to anti-mouse to seek connections with function barrier
The influence hindered.
A kind of chewing gum contains sobering-up composition 10%-20%, and remaining is matrix and flavouring.
The present invention has following beneficial effect：
The sobering-up composition of the present invention and its chewing gum being made, with good antialcoholism function, can pass through system
Evaluation system is verified.
Specific embodiment
Below in conjunction with specific embodiment, the invention will be further described：
The preparation method of sobering-up composition
Chinese herbal medicine is pre-processed：
Each 150g of the root of kudzu vine, flower of kudzuvine, radix glycyrrhizae, fructus amomi, rhizome of cyrtomium, chrysanthemum, honey, hoveniae semoveniae semen, rhizoma imperatae is weighed, in weighing
Herbal medicine is dried under the conditions of 90 DEG C in an oven respectively, and drying time is 2h, then respectively by the Chinese herbal medicine of drying pulverizer powder
It is broken, crush 30s and obtain herbal powder.
The leaching liquor of Chinese herbal medicine active component：
15g herbal powders are respectively taken, the 2h that flows back are added in the ethanol solution that 500ml concentration is 40%, control temperature is not
More than 75 DEG C, and suction filtration obtains filtrate A, gained filter residue repeat backflow 2h and suction filtration once liquor B, be collected into above-mentioned
2 kinds of filtrates A, B merge, and are concentrated under reduced pressure into no ethanol flavor at 75 DEG C, obtain no alcohol leaching liquor；
The purification of Chinese herbal medicine active component：
Gained is added into medical decoloration active carbon without alcohol leaching liquor, 10min is heated, removes peculiar smell and part resin, colloid class
Material.Suction filtration is limpid to filtrate repeatedly, untill substantially transparent, obtains sobering-up composition.
The evaluation of sobering-up composition：
Influence of the various dose alcohol gavage to mouse
Small white mouse 100 is taken, male and female half and half, random packet, at the night of fasting one (12h) before experiment, carries out resistance to wine by every group 10
Essence experiment, as a result as shown in table 1：During with 0.18ml/10g body weight gavages, mouse has half dead, and this mortality is excessive, experiment
If being likely to result in this dosage and finally lacking required data；During with 0.12ml/10g body weight gavages, mouse has half not drunk,
It can equally cause to lack test data；During with 0.14ml/10g body weight gavages, mouse is most of drunk, and revival quantity is relatively
Many, the death rate is relatively fewer, therefore dead mouse excessively caused test data to lack when both having avoided experiment, turn avoid experiment
When lack data because mouse is not drunk, therefore use 0.14ml/10g body weight for experiment white wine gavage amount.
The mouse ethanol-tolerant of table 1 is tested
Influence of the sobering-up composition of the present invention to mice serum ALT, AST is index.
ALT, AST are primarily present in liver cytoplasm, when hepatocellular injury, and intracellular transaminase can enter in blood,
So as to cause ALT, AST in blood to raise.Relatively there is significant difference (P to alcohol mouse<0.01).Prevent experimental result table
It is bright：Relieving alcoholism and protecting liver preparation of the present invention can reduce model mice Serum ALT, AST, and preventive effect is better than positive controls, illustrates this
Invention relieving alcoholism and protecting liver preparation can be absorbed by alimentary canal, play protection liver cell, suppress the rise of ALT, AST in hepatic tissue, and
The stable liver plasma membrane of energy, suppresses ALT, AST and is released into blood, so as to effectively prevent and treat alcoholic liver injury.
This experiment Chinese herbal medicine used, uses according to regulations the article specified in medicine-food two-purpose and carries out prescription, experimental animal is
The healthy mice 60 that Anhui Province's Experimental Animal Center is provided, body weight 18-22g, male and female half and half are randomly divided into 6 groups, experimental group
It is other to set normal group, model group and the positive (extra large Wang Jin cups) control group if high dose, middle dosage, low dose group, by adaptability
Tested after raising one week.
The night of fasting one (12h) before each group animal experiment in experiment.Each group is gavaged with white wine with 0.14ml/10g body weight, is given
After medicine one hour, in mouse socket of the eye artery and socket of the eye venous blood sampling, take serum to be checked, meanwhile, liver is taken rapidly, preserves treat on request
Inspection.
It should be noted that sea Wang Jin cups are a market class relieving alcoholism and protecting liver product on sale.Extra large Wang Jin needed for this experiment
Cup is bought from market.
Influence of the sobering-up composition prevention administration of table 2. to mice serum ALT
As seen from Table 2, model group Serum ALT is significantly raised compared with normal group, with significant difference P ＜ 0.01；Through prevention
Administration, the height of sobering-up composition group, middle dose group Serum ALT are significantly lower than model group, with significant difference.
Influence of the sobering-up composition prevention administration of table 3. to mice serum AST
As seen from Table 3, model group serum AST is significantly raised compared with normal group, with significant difference P ＜ 0.01；Through prevention
Administration, the high dose group AST of sobering-up composition group is less than model group, with significant difference P ＜ 0.05.
Sobering-up composition relieves the effect of alcohol the influence of situation to mouse of drinking
Healthy mice 30 is taken, body weight 18-22g, male and female half and half are raised one week, stochastic averagina is divided into 3 by adaptability
Group；If tested material group A, tested material group B and placebo, fasting 12h before each group animal experiment in experiment, 30 mouse are by X's
White wine gavage amount gavages modeling, after modeling terminates, and tested material group A is gavaged with sobering-up composition 0.3ml/10g, and tested material group B is used
Sobering-up composition 0.6ml/10g is gavaged, and placebo is gavaged with pure water 0.1ml/10g；Record tested material group A, tested material group
B and placebo are averagely sobered up the time, compare the difference existed between placebo and tested material group A, B, investigate sobering-up composition
The influence for situation of being relieved the effect of alcohol to mouse of drinking；
As can be seen from Table 4, under equivalent assay conditions, tested material group A averagely sobers up the time for 76min, tested material group B
The time averagely sober up for 65min, placebo averagely sobers up the time for 135min, intuitively finds out placebo and tested material group
There is larger difference between A, B.Examined and can see by t, tested material group A has significant difference (P ＜ with control group
0.05), there is pole significant difference (P ＜ 0.01) in tested material group B with control group.It is possible thereby to think, sobering-up composition is to liquor-saturated
Wine has obvious antialcoholism action.
First " medicine " relieves the effect of alcohol a group sleep laboratory result after drinking for table 4
Influence of the sobering-up composition to the anti-intoxication situation of mouse of drinking
Healthy mice 30 is taken, body weight 18-22g, male and female half and half are raised one week, stochastic averagina is divided into 3 by adaptability
Group；If tested material group C, tested material group D and placebo, fasting 12h before each group animal experiment in experiment, afterwards, tested material group C
Gavaged with sobering-up composition 0.3ml/10g, tested material group D is gavaged with sobering-up composition 0.6ml/10g, placebo is with pure
Water 0.1ml/10g is gavaged, and is gavaged after 10min, and 30 mouse are gavaged by X white wine gavage amount, gavages after end, records tested
Thing group C, tested material group D and placebo are averagely sobered up the time, compare the difference existed between placebo and tested material group C, D,
Investigate influence of the sobering-up composition to the anti-intoxication situation of mouse of drinking；
As can be seen from Table 5, under equivalent assay conditions, tested material group C averagely sobers up the time for 74min, tested material group D
The time averagely sober up for 59min, placebo averagely sobers up the time for 133min, intuitively finds out placebo and tested material group
There is larger difference between C, D.Examined and can see by t, tested material group C has significant difference (P ＜ with control group
0.05), there is pole significant difference (P ＜ 0.01) in tested material group D with control group.It is possible thereby to think, sobering-up composition is to having
Obvious anti-drunk function.
First " medicine " the anti-intoxication group of sleep laboratory result of wine afterwards of table 5
Note:N=10, is compared with placebo,*P<0.05, * * P<0.01
Sobering-up composition corrects the influence of ataxia situation to mouse of drinking
Healthy mice 30, body weight 18-22g, male and female half and half are raised one week, stochastic averagina is divided into 3 groups by adaptability；
If tested material group E, tested material group F and placebo, fasting 12h before each group animal experiment in experiment, 30 mouse press X white wine
Gavage amount gavages modeling, after modeling terminates, and tested material group E is gavaged with sobering-up composition 0.3ml/10g, and tested material group F is with relieving the effect of alcohol
Composition 0.6ml/10g is gavaged, and placebo is gavaged with pure water 0.1ml/10g；After 10min, all mouse are placed on vertically
Suspension it is online, record mouse is in online residence time, and by reagent sobering-up composition is caused after drinking to anti-mouse seeks connections with for observation
The influence of dysfunction；
As can be seen from Table 6, animal subject E, F groups are compared with placebo, and the time of seeking connections with all has pole significant difference
(P ＜ 0.01), show by reagent to the anti-mouse ability for seeking connections with dysfunction caused after drinking substantially, with correcting after drinking, gait is not
The ataxic effect such as steady, and how better dose is.
The small white mouse of table 6 seeks connections with result of the test
Note：N=10, is compared with placebo,*P<0.05, * * P<0.01 .
Claims (4)
1. a kind of sobering-up composition, it is characterised in that the sobering-up composition is made including following raw material：Root of kudzu vine 12-
18 parts, 12-18 parts of flower of kudzuvine, 12-18 parts of radix glycyrrhizae, 12-18 parts of fructus amomi, 12-18 parts of rhizome of cyrtomium, 12-18 parts of chrysanthemum, 12-18 parts of honey,
12-18 parts of hoveniae semoveniae semen, 12-18 parts of rhizoma imperatae, 12-18 parts of peppermint.
2. a kind of preparation method of sobering-up composition, it is characterised in that comprise the following steps：
1), Chinese herbal medicine is pre-processed：
The root of kudzu vine, flower of kudzuvine, radix glycyrrhizae, fructus amomi, rhizome of cyrtomium, chrysanthemum, hoveniae semoveniae semen, rhizoma imperatae, peppermint are first distinguished into 90 DEG C of conditions in an oven
Lower drying 2h, then respectively crushes the Chinese herbal medicine of drying with pulverizer, and the powder after crushing is uniformly mixed, Chinese herbal medicine is obtained
Powder；
2), the extraction of Chinese herbal medicine effective ingredientses：
Herbal powder is taken, it is backflow extraction 2h in 40% ethanol solution, control temperature 70-75 to be added to the concentration of 10 times of amounts
DEG C, suction filtration obtains filtrate A；Filter residue is extracted once with condition, obtains liquor B, the above-mentioned filtrate A and B being collected into is merged, at 75 DEG C
No ethanol flavor is concentrated under reduced pressure into, no alcohol leaching liquor is obtained；
3), the purifying of Chinese herbal medicine leaching liquor：
Gained is added into medical decoloration active carbon, 50-55 DEG C of heating 10min, decolouring removal of impurities without alcohol leaching liquor；Suction filtration is to base repeatedly
Untill this is transparent, honey is added, sobering-up composition is obtained.
3. a kind of evaluation method of sobering-up composition, it is characterised in that comprise the following steps：
1) the modeling condition of drunk model is determined：
Influence of the various dose alcohol gavage to mouse is investigated, the experiment white wine gavage amount of drunk mouse is determined；
Small white mouse 100 is taken, male and female half and half, random packet, tests preceding fasting 12h, carries out ethanol-tolerant experiment, make by every group 10
With the preferable white wine G of commercially available sales volume, the experiment of alcohol gavage is done according to 0.10ml/10g~0.20ml/10g body weight gavage amounts, according to
Experimental result, determines the experiment white wine gavage amount X of drunk mouse, and the standard of determination is：Mouse is most of drunk, and revival quantity is relative
More, the death rate is relatively fewer；
2) evaluation experimental：
A. influence experiment of the sobering-up composition to mice serum ALT, AST：
Healthy mice 60 is taken, body weight 18-22g, male and female half and half are raised one week, stochastic averagina is divided into 6 groups by adaptability；If
Normal group, model group, positive controls, low dosage experimental group, middle dosage experimental group, high dose experimental group, each group is moved in experiment
Fasting 12h before thing experiment, normal group is normally fed, without white wine gavage, and remaining 5 groups gavage modeling by X white wine gavage amount,
After modeling terminates, model group is without any processing, and positive controls are gavaged with sea Wang Jin cups 0.3ml/10g, low dosage experimental group
Gavaged with sobering-up composition 0.1ml/10g, middle dosage experimental group is gavaged with sobering-up composition 0.3ml/10g, high dose experimental group
Gavaged with sobering-up composition 0.6ml/10g；After gavaging administration one hour, in 6 groups of mouse socket of the eye arteries and socket of the eye venous blood sampling, serum is taken
Mice serum ALT, AST are detected, influence of the sobering-up composition to mice serum ALT, AST is investigated；
B. sobering-up composition relieves the effect of alcohol the influence of situation to mouse of drinking：
Healthy mice 30 is taken, body weight 18-22g, male and female half and half are raised one week, stochastic averagina is divided into 3 groups by adaptability；If
Tested material group A, tested material group B and placebo, fasting 12h before each group animal experiment in experiment, 30 mouse are filled by X white wine
Stomach amount gavages modeling, after modeling terminates, and tested material group A is gavaged with sobering-up composition 0.3ml/10g, tested material group B groups of relieving the effect of alcohol
Compound 0.6ml/10g is gavaged, and placebo is gavaged with pure water 0.1ml/10g；Record tested material group A, tested material group B and comfort
Agent group is averagely sobered up the time, compares the difference existed between placebo and tested material group A, B, investigates sobering-up composition small to drinking
Mouse is relieved the effect of alcohol the influence of situation；
C. influence of the sobering-up composition to the anti-intoxication situation of mouse of drinking：
Healthy mice 30 is taken, body weight 18-22g, male and female half and half are raised one week, stochastic averagina is divided into 3 groups by adaptability；If
Tested material group C, tested material group D and placebo, fasting 12h before each group animal experiment in experiment, afterwards, tested material group E solutions
Wine composition 0.3ml/10g is gavaged, and tested material group F is gavaged with sobering-up composition 0.6ml/10g, placebo pure water
0.1ml/10g is gavaged, and is gavaged after 10min, and 30 mouse are gavaged by X white wine gavage amount, gavaged after end, records tested material
Group E, tested material group F and placebo are averagely sobered up the time, are compared the difference existed between placebo and tested material group E, F, are examined
Examine influence of the sobering-up composition to the anti-intoxication situation of mouse of drinking；
D. sobering-up composition corrects the influence of ataxia situation to mouse of drinking；
Healthy mice 30, body weight 18-22g, male and female half and half are raised one week, stochastic averagina is divided into 3 groups by adaptability；If by
Thing group E, tested material group F and placebo are tried, fasting 12h before each group animal experiment in experiment, 30 mouse press X white wine gavage
Amount gavages modeling, and after modeling terminates, tested material group C is gavaged with sobering-up composition 0.3ml/10g, tested material group D combinations of relieving the effect of alcohol
Thing 0.6ml/10g is gavaged, and placebo is gavaged with pure water 0.1ml/10g；After 10min, all mouse are placed on vertical hanging
It is online, record mouse is in online residence time, and observation sobering-up composition is caused after drinking to anti-mouse to seek connections with dysfunction
Influence.
4. a kind of chewing gum containing sobering-up composition, it is characterised in that the chewing gum contains sobering-up composition 10%-
20%, remaining is matrix and flavouring.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108853416A (en) * | 2018-07-06 | 2018-11-23 | 张晓莹 | A kind of relieving alcoholism and protecting liver and the Chinese materia medica preparation and preparation method thereof for preventing and treating male sterility |
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| CN101116470A (en) * | 2007-07-17 | 2008-02-06 | 鄂州天地人健康食品有限公司 | Chewing gum for dispelling effects of alcohol and protecting liver |
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Application publication date: 20170922 |