CN108366990B - 合成的鞘脂类分子、药物、它们的合成方法及治疗方法 - Google Patents

合成的鞘脂类分子、药物、它们的合成方法及治疗方法 Download PDF

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CN108366990B
CN108366990B CN201680068271.8A CN201680068271A CN108366990B CN 108366990 B CN108366990 B CN 108366990B CN 201680068271 A CN201680068271 A CN 201680068271A CN 108366990 B CN108366990 B CN 108366990B
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compound
cells
tumor
cancer
human
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CN108366990A (zh
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艾梅·埃丁格
斯蒂芬·哈内斯伊恩
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Universite de Montreal
University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680068271.8A 2015-09-24 2016-09-26 合成的鞘脂类分子、药物、它们的合成方法及治疗方法 Expired - Fee Related CN108366990B (zh)

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US201562232377P 2015-09-24 2015-09-24
US62/232,377 2015-09-24
PCT/US2016/053815 WO2017053990A1 (en) 2015-09-24 2016-09-26 Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment

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CN108366990B true CN108366990B (zh) 2021-09-03

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EP (1) EP3352753A4 (cg-RX-API-DMAC7.html)
JP (1) JP6853539B2 (cg-RX-API-DMAC7.html)
CN (1) CN108366990B (cg-RX-API-DMAC7.html)
CA (1) CA2999177A1 (cg-RX-API-DMAC7.html)
MX (1) MX394367B (cg-RX-API-DMAC7.html)
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Cited By (1)

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Publication number Priority date Publication date Assignee Title
US11999693B2 (en) 2015-09-24 2024-06-04 The Regents Of The University Of California Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment

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JP6617702B2 (ja) 2013-07-15 2019-12-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｆｔｙ７２０のアザサイクリック拘束アナログ
EP3703653A4 (en) 2017-11-03 2021-09-08 University Of Virginia Patent Foundation COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCERS
JP2022500352A (ja) * 2018-06-14 2022-01-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California 合成細胞毒性分子、薬剤、それらの合成法および処置法
WO2021062168A1 (en) * 2019-09-25 2021-04-01 The Regents Of The University Of California Synthetic sphingolipid inspired molecules with heteroaromatic appendages, methods of their synthesis and methods of treatment
CN115003298A (zh) * 2019-11-13 2022-09-02 加利福尼亚大学董事会 用于治疗代谢障碍的药物制剂和方法
EP4090426B1 (en) 2020-01-13 2025-12-31 Verge Analytics, Inc. Substitutes for pyrazolos and pyrimidines and their uses
CN116617221B (zh) * 2022-02-11 2025-06-17 复旦大学 Trpml1特异性小分子激动剂ml-sa1在制药中的用途

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MX2018003685A (es) 2018-08-15
EP3352753A4 (en) 2019-03-13
MX394367B (es) 2025-03-24
WO2017053990A1 (en) 2017-03-30
US20210261504A1 (en) 2021-08-26
CN108366990A (zh) 2018-08-03
US11479530B2 (en) 2022-10-25
HK1259078A1 (zh) 2019-11-22
US11999693B2 (en) 2024-06-04
CA2999177A1 (en) 2017-03-30
EP3352753A1 (en) 2018-08-01
US10995068B2 (en) 2021-05-04
JP2018534256A (ja) 2018-11-22
JP6853539B2 (ja) 2021-03-31
US20180265464A1 (en) 2018-09-20
US20230122855A1 (en) 2023-04-20

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