CN1083280C - 用于诊断和治疗的新的靶向组合物 - Google Patents

用于诊断和治疗的新的靶向组合物 Download PDF

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Publication number
CN1083280C
CN1083280C CN96194499A CN96194499A CN1083280C CN 1083280 C CN1083280 C CN 1083280C CN 96194499 A CN96194499 A CN 96194499A CN 96194499 A CN96194499 A CN 96194499A CN 1083280 C CN1083280 C CN 1083280C
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CN
China
Prior art keywords
gas
vesicles
lipid
vesicle
targeting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN96194499A
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English (en)
Chinese (zh)
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CN1187137A (zh
Inventor
埃文·C·翁格尔
沈德康
吴观丽
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ImaRx Pharmaceutical Corp
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ImaRx Pharmaceutical Corp
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Application filed by ImaRx Pharmaceutical Corp filed Critical ImaRx Pharmaceutical Corp
Publication of CN1187137A publication Critical patent/CN1187137A/zh
Application granted granted Critical
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/228—Host-guest complexes, clathrates, chelates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN96194499A 1995-06-07 1996-06-06 用于诊断和治疗的新的靶向组合物 Expired - Fee Related CN1083280C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49768495A 1995-06-07 1995-06-07
US64046496A 1996-05-01 1996-05-01
US08/640,464 1996-05-01
US08/497,684 1996-05-01

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN02105309A Division CN1397348A (zh) 1995-06-07 2002-02-22 用于诊断和治疗的新的靶向组合物

Publications (2)

Publication Number Publication Date
CN1187137A CN1187137A (zh) 1998-07-08
CN1083280C true CN1083280C (zh) 2002-04-24

Family

ID=27052585

Family Applications (2)

Application Number Title Priority Date Filing Date
CN96194499A Expired - Fee Related CN1083280C (zh) 1995-06-07 1996-06-06 用于诊断和治疗的新的靶向组合物
CN02105309A Pending CN1397348A (zh) 1995-06-07 2002-02-22 用于诊断和治疗的新的靶向组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN02105309A Pending CN1397348A (zh) 1995-06-07 2002-02-22 用于诊断和治疗的新的靶向组合物

Country Status (8)

Country Link
EP (2) EP0831932B1 (cg-RX-API-DMAC7.html)
JP (1) JP4215820B2 (cg-RX-API-DMAC7.html)
CN (2) CN1083280C (cg-RX-API-DMAC7.html)
AT (1) ATE265863T1 (cg-RX-API-DMAC7.html)
AU (1) AU709562B2 (cg-RX-API-DMAC7.html)
CA (1) CA2218541A1 (cg-RX-API-DMAC7.html)
DE (1) DE69632401T2 (cg-RX-API-DMAC7.html)
WO (1) WO1996040285A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100402092C (zh) * 2005-06-07 2008-07-16 西安交通大学 血栓诊断和/或治疗用含气干粉活性剂及其制备工艺

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CN110591054B (zh) * 2019-09-17 2021-05-18 江苏泰特尔新材料科技股份有限公司 一种总氯含量低、无重金属残留的环氧化物及其合成工艺
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Also Published As

Publication number Publication date
DE69632401T2 (de) 2005-05-19
ATE265863T1 (de) 2004-05-15
EP0831932B1 (en) 2004-05-06
WO1996040285A1 (en) 1996-12-19
DE69632401D1 (de) 2004-06-09
CA2218541A1 (en) 1996-12-19
CN1397348A (zh) 2003-02-19
AU6270396A (en) 1996-12-30
EP1444991A1 (en) 2004-08-11
JP4215820B2 (ja) 2009-01-28
CN1187137A (zh) 1998-07-08
EP0831932A4 (en) 2000-01-12
JPH11507638A (ja) 1999-07-06
AU709562B2 (en) 1999-09-02
EP0831932A1 (en) 1998-04-01

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