CN108310301A - A kind of external-applied ointment of deep layer maintenance onychomycosis - Google Patents
A kind of external-applied ointment of deep layer maintenance onychomycosis Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
This case is related to a kind of external-applied ointment of deep layer maintenance onychomycosis, including traditional Chinese medicine extraction component and chemical agent component, the raw material of traditional Chinese medicine extraction component includes radix stemonae sessilifoliae, kuh-seng, menthol, borneol, tsaoko and the seed of garden balsam, and chemical agent component includes allantoin, ester acid chlorohexidene, erythromycin tablet and sulphathiazole；External-applied ointment according to the present invention is mainly for onychomycosis, it is mildly repaired using Chinese herb medicine, deep layer is nourished, in combination with specific chemical agent with quick sterilization anti-inflammatory, by promoting nail resistance, make to bleach originally, thicken, turn to be yellow, detrital deposit, frangible, the nail rehabilitation that tilts, to thoroughly activate onychomycosis.
Description
Technical field
The present invention relates to field of medicaments, and in particular to a kind of external-applied ointment of deep layer maintenance onychomycosis.
Background technology
Onychomycosis, scientific name onychomycosis are nail or toenail caused by the pathomycetes such as dermatophytes, saccharomycete and non-dermatophytes
Infection, multiple color, most commonly canescence, also brown, taupe or dark brown can occur in sick first, while first occur
Plate thickens, become fragile or deck middle level is eaten hollow or the symptoms such as deck is incomplete, and some is also with nail groove inflammation, the red and swollen pain in part
Pain etc..
Currently, the method for the treatment of onychomycosis includes oral drug therapy, pulls out first treatment and external medication etc., oral medicine
There are commonly Sporanox, hydrochloric acid spies for object than resistance to phenol, Fluconazole etc., and treatment time is long, big to body side effect；Pull out first treatment pain
Pain degree is big, influences life and work, and it is high to recur probability；External used medicine is mostly antimycotic chemical agent, and permeability is poor, it is difficult to
It arrives at fungi, curative effect unobvious.Therefore the urgent specific medicament for onychomycosis treatment maintenance, not only has a vast market
Foreground, and can also bring glad tidings for many patients.
Invention content
Shortcoming in being treated for existing onychomycosis, the purpose of the present invention is to provide a kind of deep layer maintenance onychomycosis
External-applied ointment.
The present invention provides a kind of external-applied ointments of deep layer maintenance onychomycosis, including traditional Chinese medicine extraction component and chemical agent group
Point；Wherein, the raw material of the traditional Chinese medicine extraction component includes radix stemonae sessilifoliae, kuh-seng, menthol, borneol, tsaoko and the seed of garden balsam, described
Chemical agent component includes allantoin, ester acid chlorohexidene, erythromycin tablet and sulphathiazole.
Preferably, the raw material dosage of the traditional Chinese medicine extraction component is as follows:
Preferably, the dosage of each medicament is as follows in the chemical agent component：
Preferably, the traditional Chinese medicine extraction component includes liquid component and solid component, and preparation process is as follows：
1) radix stemonae sessilifoliae, kuh-seng, tsaoko, the seed of garden balsam are crushed and crosses aperture 3-5mm sieves, to the uniform herbal medicine after sieving
The glycerine of the pure water and 0.5-0.8 times of volume of 5-8 times of volume is added in particle, is decocted 1 hour at 80-90 DEG C, filters, and
Collect filtrate；The glycerine of the pure water and 0.3-0.5 times of volume of 3-5 times of volume is added again into the dregs of a decoction, is decocted at 80-90 DEG C
It boils 1 hour, filters, and collect filtrate；
2) merge the filtrate in step 1), borneol and menthol are added thereto, big fire decoction under the conditions of boiling, concentration
Filtrate volume is kept the temperature to original 5-8% at 70-75 DEG C, obtains traditional Chinese medicine extraction liquid component；
3) filter residue in step 1) dried at 75-80 DEG C, crushed, crossed 800-1000 mesh dusting covers, obtain traditional Chinese medicine extraction
Solid component.
Preferably, the chemical agent component is crossed 800-1000 mesh dusting covers, is obtained according to being fully ground after weight ligand
Chemical agent component fine powder.
Preferably, the traditional Chinese medicine extraction component and chemical agent component mix by the following method：Continuously stirring item
Under part, traditional Chinese medicine extraction solid component and chemical agent component fine powder are added into traditional Chinese medicine extraction liquid component, is warming up to 65-70
DEG C, it is slowly added to suitable glycerine and stearic acid, keeps stirring and is cooled to room temperature, obtains externally applied ointment.
Preferably, the weight of the traditional Chinese medicine extraction liquid component, traditional Chinese medicine extraction solid component and chemical agent component is matched
Than being 100: 40-42: 18-20.
Beneficial effects of the present invention：External-applied ointment according to the present invention is mainly for onychomycosis (onychomycosis), using medium-height grass
Medicine warm and reparation, deep layer are nourished, and in combination with specific chemical agent with quick sterilization anti-inflammatory, are resisted by promoting nail
Power, make to bleach originally, thicken, turn to be yellow, detrital deposit, frangible, finger (toe) first rehabilitation for tilting, to thoroughly activate onychomycosis.
The ointment of maintenance onychomycosis in this case is prepared using Integrated TCM, and traditional Chinese medicinal components include mainly radix stemonae sessilifoliae, kuh-seng, peppermint
The raw materials such as brain, borneol, tsaoko and the seed of garden balsam are processed according to the technique in the present invention, enable active ingredient in each raw material
It is utmostly played, sterilization antalgesic-antipruritic, anti-inflammatory are anti-oxidant and small to the stimulation in affected part, and mutually coordinated effect is realized
To infecting the nourishing maintenance of nail, finger (toe) first that maintenance damages from root, wherein glycerine is added in concocting process, Neng Gougeng
The good effect ingredient extracted in Chinese medicine material；In order to overcome the problems, such as that external application Chinese medicine drug effect is slow, course for the treatment of length, inventor passes through
Many experiments add the chemical agents components such as allantoin, ester acid chlorohexidene, erythromycin tablet and sulphathiazole in ointment, will
They are mixed after milling with Chinese medicine preparation, add glycerine and stearic acid, obtain medicine creamy product, and chemical agent component is mutually assisted
Tune acts on the affected part that can quickly go directly and carries out bactericidal antiphlogistic, greatly shortens the healing course for the treatment of, while traditional Chinese medicinal components can coordinate to suffering from
Place carries out nourishing reparation, to realize fully recovering for onychomycosis.
Specific implementation mode
With reference to embodiment, the present invention is described in further detail, to enable those skilled in the art with reference to specification
Word can be implemented according to this.The present invention provides a kind of external-applied ointment of deep layer maintenance onychomycosis, by following embodiments and
Comparative example is specifically described.
Embodiment 1
It is prepared by traditional Chinese medicinal components：
1) by 33 parts by weight radix stemonae sessilifoliaes, 26 parts by weight kuh-sengs, 15 parts by weight tsaokos, the crushing of the 16 parts by weight seeds of garden balsam and mistake
Aperture 5mm sieves the glycerine of the pure water and 0.8 times of volume of 8 times of volumes are added into the uniform herbal granules after sieving, 90
It decocts 1 hour, filters, and collect filtrate at DEG C；Be added again into the dregs of a decoction 5 times of volumes pure water and 0.5 times of volume it is sweet
Oil decocts 1 hour at 90 DEG C, filtering, and collects filtrate；
2) merge the filtrate in step 1), 6 parts by weight borneols and 8 parts by weight menthols are added thereto, in boiling condition
Lower big fire decocts, and concentration filtrate volume keeps the temperature at 75 DEG C to original 8%, obtains traditional Chinese medicine extraction liquid component；
3) filter residue in step 1) dried at 75 DEG C, crushed, crossed 1000 mesh dusting covers, obtain traditional Chinese medicine extraction solid group
Point.
Chemical agent component pre-processes：By 28 parts by weight allantoins, 33 parts by weight ester acid chlorohexidenes, 13 parts by weight erythromycin
Piece, 5 parts by weight sulphathiazole cross 1000 mesh dusting covers, obtain chemical agent component fine powder according to being fully ground after weight proportion.
The preparation of external-applied ointment：Under continual stirring conditions, 40 weights are added into 100 parts by weight traditional Chinese medicine extraction liquid components
Part traditional Chinese medicine extraction solid component and 20 parts by weight chemical agent component fine powders are measured, 70 DEG C is warming up to, is slowly added to suitable glycerine
And stearic acid, it keeps stirring and is cooled to room temperature, obtain externally applied ointment.
Embodiment 2
It is prepared by traditional Chinese medicinal components：
1) by 28 parts by weight radix stemonae sessilifoliaes, 22 parts by weight kuh-sengs, 11 parts by weight tsaokos, the crushing of the 13 parts by weight seeds of garden balsam and mistake
Aperture 4mm sieves the glycerine of the pure water and 0.6 times of volume of 6 times of volumes are added into the uniform herbal granules after sieving, 85
It decocts 1 hour, filters, and collect filtrate at DEG C；Be added again into the dregs of a decoction 4 times of volumes pure water and 0.5 times of volume it is sweet
Oil decocts 1 hour at 85 DEG C, filtering, and collects filtrate；
2) merge the filtrate in step 1), 5 parts by weight borneols and 6 parts by weight menthols are added thereto, in boiling condition
Lower big fire decocts, and concentration filtrate volume keeps the temperature at 70 DEG C to original 6%, obtains traditional Chinese medicine extraction liquid component；
3) filter residue in step 1) dried at 75 DEG C, crushed, crossed 800 mesh dusting covers, obtain traditional Chinese medicine extraction solid component.
Chemical agent component pre-processes：By 25 parts by weight allantoins, 30 parts by weight ester acid chlorohexidenes, 11 parts by weight erythromycin
Piece, 3 parts by weight sulphathiazole cross 800 mesh dusting covers, obtain chemical agent component fine powder according to being fully ground after weight proportion.
The preparation of external-applied ointment：Under continual stirring conditions, 42 weights are added into 100 parts by weight traditional Chinese medicine extraction liquid components
Part traditional Chinese medicine extraction solid component and 18 parts by weight chemical agent component fine powders are measured, 70 DEG C is warming up to, is slowly added to suitable glycerine
And stearic acid, it keeps stirring and is cooled to room temperature, obtain externally applied ointment.
The dosage of raw material is adjusted in the range of the present invention limits on the basis of embodiment 1, remaining system
Preparation Method is same as Example 1.
Comparative example 1
Traditional Chinese medicinal components preparation process is same as Example 1, does not add chemical agent component, i.e., under continual stirring conditions,
60 parts by weight traditional Chinese medicine extraction solid components are added into 100 parts by weight traditional Chinese medicine extraction liquid components, is warming up to 70 DEG C, is slowly added to
Suitable glycerine and stearic acid, keep stirring and are cooled to room temperature, obtain the externally applied ointment of maintenance onychomycosis.
Comparative example 2
Without using traditional Chinese medicinal components, by 28 parts by weight allantoins, 33 parts by weight ester acid chlorohexidenes, 13 parts by weight erythromycin tablets, 5
Parts by weight sulphathiazole crosses 1000 mesh dusting covers, chemical agent component fine powder is obtained, continuous according to being fully ground after weight proportion
Under stirring condition, it is slowly added to suitable glycerine and stearic acid into chemical agent component fine powder at 70 DEG C, is kept stirring cold
But room temperature is arrived, externally applied ointment is obtained.
Comparative example 3
Traditional Chinese medicinal components preparation process is same as Example 1.
Chemical agent component pre-processes：By 33 parts by weight ester acid chlorohexidenes, 13 parts by weight erythromycin tablets, 5 parts by weight sulfanilamide (SN)
Thiazole crosses 1000 mesh dusting covers, obtains western medicine component fine powder according to being fully ground after weight proportion.
The preparation process of external-applied ointment is same as Example 1, i.e., by allantoin ingredient in the chemical agent component of embodiment 1
Remove, remaining composition is same as Example 1.
Comparative example 4
Traditional Chinese medicinal components preparation process is same as Example 1.
Chemical agent component pre-processes：By 28 parts by weight allantoins, 13 parts by weight erythromycin tablets, 5 parts by weight sulphathiazole
According to being fully ground after weight proportion, 1000 mesh dusting covers are crossed, western medicine component fine powder is obtained.
The preparation process of external-applied ointment is same as Example 1, i.e., by ester acid chlorohexidene in the chemical agent component of embodiment 1
Ingredient removes, remaining composition is same as Example 1.
Comparative example 5
Traditional Chinese medicinal components preparation process is same as Example 1.
Chemical agent component pre-processes：By 28 parts by weight allantoins, 33 parts by weight ester acid chlorohexidenes according to weight proportion after
It is fully ground, crosses 1000 mesh dusting covers, obtain western medicine component fine powder.
The preparation process of external-applied ointment is same as Example 1, i.e., by erythromycin tablet in the chemical agent component of embodiment 1 and
Sulphathiazole ingredient removes, remaining composition is same as Example 1.
Comparative example 6
The external-applied ointment of commercially available treatment onychomycosis.
The effect of external-applied ointment of the present inventor in order to prove and investigate mid-deep strata maintenance onychomycosis of the present invention, leads to
Impression on probation is crossed to evaluate plaster effect in embodiment 1-2 and comparative example 1-6, using opinion poll point system, according to voluntary
Principle has randomly selected 240 onychomycosis patients as volunteer, male 120, women 120, the age at 20-50 Sui, disease
Journey was arbitrarily divided into eight groups -3 years January, the plaster treatment onychomycosis in embodiment 1-2 and comparative example 1-6 was used respectively, per angel
With 2 times, use 15 days.Every using effect total score is 5 points：4-5 points indicate to feel quite pleased；3-4 points indicate relatively satisfactory；2-3 divides table
Show general satisfaction；2 points of following presentations are dissatisfied, cannot receive.Every average is recorded and calculated, the results are shown in Table 1.
The onychomycosis patient for smearing ointment (i.e. Examples 1 and 2) involved in the present invention, in 15 days trial employment periods, illness
Nail quality and color perfecting are good, and the table of the antibacterial effect to ointment, compliance, absorbability, anti-inflammatory etc.
Now all feel quite pleased；There was only traditional Chinese medicinal components in comparative example 1, there was only chemical agent component in comparative example 2, relative to embodiment 1, comparison
The patient satisfaction of example 1 and 2 is relatively low, especially in terms of to nail quality and color perfecting, does not all reach the standard felt quite pleased,
The Chinese and Western medicine component of this explanation only composition ointment is mutually coordinated to coordinate the therapeutic effect that can have just had；In comparative example 3-5, chemistry
Dosage component has lacked one or two, and the therapeutic effect of gained ointment is remarkably decreased compared with embodiment 1, this illustrates chemical agent
Exist between four raw materials and between traditional Chinese medicinal components and cooperate, coordinative role could realize that high-efficiency antimicrobial and maintenance ash refer to
First；Comparative example 6 is treatment onychomycosis ointment on sale on the market, and therapeutic effect and user satisfaction are said far away from embodiment 1
Treatment onychomycosis ointment prepared by the bright present invention is good compared with existing product therapeutic effect, and advantage is notable.
Table 1
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details.
Claims (7)
1. a kind of external-applied ointment of deep layer maintenance onychomycosis, which is characterized in that including traditional Chinese medicine extraction component and chemical agent component；
Wherein, the raw material of the traditional Chinese medicine extraction component includes radix stemonae sessilifoliae, kuh-seng, menthol, borneol, tsaoko and the seed of garden balsam, describedization
It includes allantoin, ester acid chlorohexidene, erythromycin tablet and sulphathiazole to learn dosage component.
2. external-applied ointment according to claim 1, which is characterized in that the raw material dosage of the traditional Chinese medicine extraction component is as follows：
3. externally applied ointment according to claim 1, which is characterized in that the dosage of each medicament is such as in the chemical agent component
Under：
4. externally applied ointment according to claim 1, which is characterized in that the traditional Chinese medicine extraction component includes liquid component and consolidates
Body component, preparation process are as follows：
1) radix stemonae sessilifoliae, kuh-seng, tsaoko, the seed of garden balsam are crushed and crosses aperture 3-5mm sieves, to the uniform herbal granules after sieving
The glycerine of the middle pure water and 0.5-0.8 times of volume that 5-8 times of volume is added, decocts 1 hour at 80-90 DEG C, filters, and collect
Filtrate；The glycerine of the pure water and 0.3-0.5 times of volume of 3-5 times of volume is added again into the dregs of a decoction, 1 is decocted at 80-90 DEG C
Hour, filtering, and collect filtrate；
2) merge the filtrate in step 1), borneol and menthol are added thereto, big fire decoction under the conditions of boiling concentrates filtrate
Volume is kept the temperature to original 5-8% at 70-75 DEG C, obtains traditional Chinese medicine extraction liquid component；
3) filter residue in step 1) dried at 75-80 DEG C, crushed, crossed 800-1000 mesh dusting covers, obtain traditional Chinese medicine extraction solid
Component.
5. externally applied ointment according to claim 1, which is characterized in that the chemical agent component after weight ligand according to filling
Divide grinding, crosses 800-1000 mesh dusting covers, obtain chemical agent component fine powder.
6. externally applied ointment according to claim 4 or 5, which is characterized in that the traditional Chinese medicine extraction component and chemical agent group
Divide and mixes by the following method：Under continual stirring conditions, traditional Chinese medicine extraction solid component is added into traditional Chinese medicine extraction liquid component
With chemical agent component fine powder, it is warming up to 65-70 DEG C, suitable glycerine and stearic acid is slowly added to, keeps stirring and be cooled to room
Temperature obtains externally applied ointment.
7. externally applied ointment according to claim 6, which is characterized in that the traditional Chinese medicine extraction liquid component, traditional Chinese medicine extraction are solid
The weight proportion of body component and chemical agent component is 100: 40-42: 18-20.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109925502A (en) * | 2019-04-09 | 2019-06-25 | 秦俊俊 | A kind of externally applied drug and preparation method thereof for treating onychomycosis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109925502A (en) * | 2019-04-09 | 2019-06-25 | 秦俊俊 | A kind of externally applied drug and preparation method thereof for treating onychomycosis |
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Effective date of registration: 20180920 Address after: 215129 668 Taishan Road, hi tech Zone, Suzhou, Jiangsu Applicant after: JIANGSU QILIKANG SKIN PHARMACEUTICAL CO., LTD. Address before: 314100 4C, 3 Jiashan Road, Dayun Town, Jiashan, Jiaxing, Zhejiang, China, 3 Applicant before: Jiashan County Hong Biotechnology Co. Ltd. |
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