CN108310152A - It is a kind of to be used to treat medicinal liquor of rheumatism bone disease and preparation method thereof - Google Patents

It is a kind of to be used to treat medicinal liquor of rheumatism bone disease and preparation method thereof Download PDF

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CN108310152A
CN108310152A CN201810414112.XA CN201810414112A CN108310152A CN 108310152 A CN108310152 A CN 108310152A CN 201810414112 A CN201810414112 A CN 201810414112A CN 108310152 A CN108310152 A CN 108310152A
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chinese medicine
medicine composition
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medicinal liquor
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韩冬梅
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Abstract

The present invention provides a kind of for treating medicinal liquor of rheumatism bone disease and preparation method thereof.The composition is mainly that the Chinese medicine composition being made of bulk pharmaceutical chemicals such as Radix Angelicae Sinensis, cassia twig, safflowers and liquor made from sorghum are prepared；The medicinal liquor has good therapeutic effect to rheumatism bone diseases such as rheumatic arthritis, rheumatoid arthritis, hypertrophic arthritis, scapulohumeral periarthritis and cervical spondylosiss.

Description

It is a kind of to be used to treat medicinal liquor of rheumatism bone disease and preparation method thereof
Technical field
It is the present invention relates to the field of Chinese medicines, more particularly to a kind of for treating medicinal liquor of rheumatism bone disease and preparation method thereof.
Background technology
Rheumatism bone disease and rheumatoid osteopathia are all systemic diseases, are common disease, frequently-occurring disease in China, number of patients is more； Rheumatism bone disease be mainly the blood circulation caused by chill it is obstructed, cause include flesh, ligament, synovial bursa, fascia nutrition supplying To bad caused disease, arthropathy, still with swelling and moving obstacle, is in that breaking-out and alleviation are alternate slow in addition to having pain Venereal disease journey, some patientss may occur in which that joint is disabled and viscera function exhaustion；Many patients groan deeply, very painful, serious The normal study and work of patient is affected, and also has great harm to physically and mentally healthy and appearance.
That there are therapeutic effects is poor for existing drug, the problems such as being difficult to effect a radical cure, meanwhile, the medicinal liquor one of existing treatment rheumatism bone disease As only Chinese medicine be positioned in wine impregnate for a long time, medicinal liquor made from this method is undesirable to the therapeutic effect of rheumatism bone disease, and Under long period of soaking, Chinese medicine qualitative change is soft, or even floats or be deposited in medicinal liquor in bulk, there is a problem of that clarity difference is bad, Influence the quality of medicinal liquor.
Invention content
The problems such as in order to solve to treat the medicinal liquor weak curative effect and poor clarity of rheumatism bone disease in the prior art, the present invention provide It is a kind of for treating medicinal liquor of rheumatism bone disease and preparation method thereof, the medicinal liquor to rheumatic arthritis, rheumatoid arthritis, The rheumatism bone diseases such as hypertrophic arthritis, scapulohumeral periarthritis and cervical spondylosis have good therapeutic effect.
Specific technical solution of the present invention is as follows：
The present invention provides a kind of medicinal liquor for treating rheumatism bone disease, which includes mainly 345-928 parts by weight The liquor made from sorghum of Chinese medicine composition and 5000-30000 parts by weight, the Chinese medicine composition by following parts by weight raw material prepare and At：
The liquor made from sorghum that the liquor made from sorghum is 55 ° -60 °.
The present invention show that each bulk pharmaceutical chemicals in combination of the above object can be played with liquor made from sorghum cooperates with work by largely testing With reaching live Lip river, strong waist analgesic, warming kidney and enhancing yang, mends marrow strengthen bone, dehumidifying of but trembling with fear, broken long-pending scattered silt, dispersing swelling and dissipating binds, the bonesetting of logical muscle and stretch The effect of muscle, it can effectively treat chill wet arthritis, hypertrophic arthritis, the rheumatism bone diseases such as arteriosclerosis and obstruction of lower limbs, lumber ertebral disc is swollen Go out, prominent abjection, scapulohumeral periarthritis, sciatica, cervical spondylosis, thoracic vertebrae disease, acute and chronic lumbar sprain, spinal canal stenosis, osteoproliferation etc. Disease.
Further to improve, which includes the liquor made from sorghum of the Chinese medicine composition and 15000 parts by weight of 630 parts by weight, institute Chinese medicine composition is stated to be prepared by the raw material of following parts by weight：
The liquor made from sorghum that the liquor made from sorghum is 60 °.
Further to improve, the aconiti preparata,radix is to process Radix Aconiti, the wild aconite root be Radix Aconiti Kusnezoffii is processed and At the concocting method of the aconiti preparata,radix and wild aconite root is specially：
The concocting method of aconiti preparata,radix：Frying 20-30 minutes, the then life after frying under the conditions of 100 DEG C by Radix Aconiti The rice vinegar that 0.1-0.5 times of weight is sprayed on the surface of monkshood continues frying 5-10 minutes to get aconiti preparata,radix；
The concocting method of wild aconite root：Frying 20-30 minutes, the then life after frying under the conditions of 100 DEG C by Radix Aconiti Kusnezoffii The rice vinegar that 0.1-0.5 times of weight is sprayed on the surface of radix aconiti agrestis continues frying 5-10 minutes to get wild aconite root.
The present invention prepares aconiti preparata,radix, wild aconite root by above method, can preferably in Chinese medicine composition other are former Material medicine is coordinated, and therapeutic effect of the medicinal liquor to rheumatoid arthritis is promoted.
The present invention also provides a kind of method preparing the medicinal liquor for treating rheumatism bone disease, this method includes following step Suddenly：
(1)：The Chinese medicine composition of formula ratio is taken to be positioned in non-metallic vessel, then to take the liquor made from sorghum of formula ratio to be positioned over non- It is uniformly mixed with Chinese medicine composition in metalware, non-metallic vessel is sealed, be put into native stove boiler, in 100 DEG C of conditions Lower distillation distills product in 12-24 hours to get mixing；
(2)：Will step (1) mixing distillation product weather exposure obtained 7-15 days to get.
The present invention can further promote Chinese medicine group by the medicinal liquor for treating rheumatism bone disease prepared by above method The synergistic effect for closing each bulk pharmaceutical chemicals and liquor made from sorghum in object, improves therapeutic effect of the medicinal liquor to cervical spondylosis to greatest extent.
It is further to improve, further include Chinese medicine group before Chinese medicine composition is positioned in non-metallic vessel in step (1) The pre-treatment step of object is closed, specially：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned in extractor after cleaning Three times, the water of Chinese medicine composition 8-10 times of weight of total weight is added, every time extraction 2-3 hours in extracting in water every time, merges each Secondary liquid simultaneously filters, and obtains traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, is warming up to 80-100 DEG C, 20-30 Sodium bicarbonate is added after minute and adjusts pH value to 6.5, adds the complex enzyme of 1-20 parts by weight, 20- is digested under the conditions of 80 DEG C 30 minutes, it is cooled to 30-40 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, is kept for 5-10 minutes, is taken out, concentration, drying to powder, To obtain the final product.
The present invention, can by before Chinese medicine composition is put into non-metallic vessel, being pre-processed to Chinese medicine composition Further to extract the active ingredient in Chinese medicine composition, and by enzyme solution to traditional Chinese medicine composition extract liquid at Reason, cellulase, pectase and glucuroide synergistic effect, can further improve the work of the alleviation to osteoproliferation pain With.
It is further to improve, the complex enzyme include the cellulase of 0.2-5 parts by weight, 0.5-10 parts by weight pectase With the glucuroide of 0.3-5 parts by weight.
It is further to improve, in the step (2) will step (1) mixing distillation product weather exposure obtained 7-15 days it Afterwards, further include flocculation step, specially：
a：The mixed flocculation agent of 3-12 parts by weight is positioned in container and is uniformly mixed, mixed flocculation agent total weight is added The water dilution of 100-150 times of weight, obtains mixed flocculation solution；
b：Medicinal liquor after weather exposure 7-15 days is placed and is stirred 10 minutes with 10-20 revs/min of speed at room temperature, Mixed flocculation solution made from step a is instilled with the speed of 3-5 seconds/drop in medicinal liquor, continues to stir 20-30 points after being added dropwise Clock, after standing 24 hours supernatant and precipitation, will mix with supernatant after precipitation filtering to get.
It is further to improve, the mixed flocculation agent include the aluminium silicate polymer of 1-5 parts by weight, 1-5 parts by weight bentonite With the ZC-101 flocculants of 1-2 parts by weight.
The mixed flocculation agent pair that the present invention is formed by the way that aluminium silicate polymer, bentonite and ZC-101 flocculants are added in medicinal liquor Medicinal liquor flocculates, and can greatly improve the clarity of medicinal liquor.
Medicinal liquor provided by the invention has effects that treat rheumatism bone disease well, especially to rheumatic arthritis, class wind The rheumatism bone diseases such as wet arthritis, hypertrophic arthritis, scapulohumeral periarthritis and cervical spondylosis have good therapeutic effect.
Specific implementation mode
Embodiment 1
A kind of medicinal liquor for treating rheumatism bone disease, which includes the Chinese medicine composition and 5000 weight of 345 parts by weight The liquor made from sorghum of part, the Chinese medicine composition are prepared by the raw material of following parts by weight：
Wherein, the liquor made from sorghum that liquor made from sorghum is 55 °.
Embodiment 2
A kind of medicinal liquor for treating rheumatism bone disease, which includes the Chinese medicine composition and 15000 weight of 630 parts by weight The liquor made from sorghum of part, the Chinese medicine composition are prepared by the raw material of following parts by weight：
Wherein, the liquor made from sorghum that liquor made from sorghum is 60 °；
The concocting method of aconiti preparata,radix：By Radix Aconiti under the conditions of 100 DEG C frying 25 minutes, the then Radix Aconiti after frying Surface spray the rice vinegar of 0.3 times of weight and continue frying 8 minutes to get aconiti preparata,radix；
The concocting method of wild aconite root：By Radix Aconiti Kusnezoffii under the conditions of 100 DEG C frying 25 minutes, the then Radix Aconiti Kusnezoffii after frying Surface spray the rice vinegar of 0.3 times of weight and continue frying 8 minutes to get wild aconite root；
The preparation method of the medicinal liquor is：
(1)：The Chinese medicine composition of formula ratio is taken to be positioned in non-metallic vessel, then to take the liquor made from sorghum of formula ratio to be positioned over non- It is uniformly mixed with Chinese medicine composition in metalware, non-metallic vessel is sealed, be put into native stove boiler, in 100 DEG C of conditions Lower distillation distills product in 12 hours to get mixing；
(2)：Will step (1) mixing distillation product weather exposure obtained 7 days to get.
Embodiment 3
A kind of medicinal liquor for treating rheumatism bone disease, which includes the Chinese medicine composition and 30000 weight of 928 parts by weight The liquor made from sorghum of part, the Chinese medicine composition are prepared by the raw material of following parts by weight：
Wherein, the liquor made from sorghum that liquor made from sorghum is 60 °；
The concocting method of aconiti preparata,radix：By Radix Aconiti under the conditions of 100 DEG C frying 30 minutes, the then Radix Aconiti after frying Surface spray the rice vinegar of 0.5 times of weight and continue frying 10 minutes to get aconiti preparata,radix；
The concocting method of wild aconite root：By Radix Aconiti Kusnezoffii under the conditions of 100 DEG C frying 30 minutes, the then Radix Aconiti Kusnezoffii after frying Surface spray the rice vinegar of 0.5 times of weight and continue frying 10 minutes to get wild aconite root；
The preparation method of the medicinal liquor is：
(1)：The Chinese medicine composition of formula ratio is taken to be positioned in non-metallic vessel, then to take the liquor made from sorghum of formula ratio to be positioned over non- It is uniformly mixed with Chinese medicine composition in metalware, non-metallic vessel is sealed, be put into native stove boiler, in 100 DEG C of conditions Lower distillation distills product in 24 hours to get mixing；
(2)：Will step (1) mixing distillation product weather exposure obtained 15 days to get.
Embodiment 4
A kind of medicinal liquor for treating rheumatism bone disease is in place of the difference with embodiment 2, by Chinese medicine group in step (1) Further include the pre-treatment step of Chinese medicine composition, specially before conjunction object is positioned in non-metallic vessel：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned in extractor after cleaning Extracting in water three times, is added the water of Chinese medicine composition 8 times of weight of total weight, every time extraction 2 hours, merges each secondary liquid every time And filter, obtain traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, is warming up to 80 DEG C, is added after twenty minutes Enter sodium bicarbonate and adjust pH value to 6.5, adds the complex enzyme of 1 parts by weight, digested 20 minutes under the conditions of 80 DEG C, be cooled to 30 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, is kept for 5 minutes, is taken out, concentration is dry to powder, i.e., ；
Complex enzyme includes the glucoside of the cellulase of 0.2 parts by weight, the pectase of 0.5 parts by weight and 0.3 parts by weight Enzyme.
Embodiment 5
A kind of medicinal liquor for treating rheumatism bone disease is in place of the difference with embodiment 2, by Chinese medicine group in step (1) Further include the pre-treatment step of Chinese medicine composition, specially before conjunction object is positioned in non-metallic vessel：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned in extractor after cleaning Extracting in water three times, is added the water of Chinese medicine composition 9 times of weight of total weight, every time extraction 2.5 hours, merges each secondary medicine every time Liquid simultaneously filters, and obtains traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, is added after being warming up to 90 DEG C, 30 minutes Enter sodium bicarbonate and adjust pH value to 6.5, adds the complex enzyme of 10 parts by weight, digest 25 minutes, be cooled under the conditions of 80 DEG C 35 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, is kept for 8 minutes, is taken out, concentration is dry to powder, i.e., ；
Complex enzyme includes the glucuroide of the cellulase of 3 parts by weight, the pectase of 5 parts by weight and 3 parts by weight.
Embodiment 6
A kind of medicinal liquor for treating rheumatism bone disease is in place of the difference with embodiment 2, by Chinese medicine group in step (1) Further include the pre-treatment step of Chinese medicine composition, specially before conjunction object is positioned in non-metallic vessel：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned in extractor after cleaning Extracting in water three times, is added the water of Chinese medicine composition 10 times of weight of total weight, every time extraction 3 hours, merges each secondary medicine every time Liquid simultaneously filters, and obtains traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, after being warming up to 100 DEG C, 30 minutes Sodium bicarbonate is added and adjusts pH value to 6.5, adds the complex enzyme of 20 parts by weight, is digested 30 minutes under the conditions of 80 DEG C, cooled down To 40 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, is kept for 10 minutes, is taken out, concentration is dry to powder, i.e., ；
Complex enzyme includes the glucuroide of the cellulase of 5 parts by weight, the pectase of 10 parts by weight and 5 parts by weight.
Embodiment 7
It is a kind of and to be in place of the difference of embodiment 2 for treating the medicinal liquor of rheumatism bone disease,
The preparation method of the medicinal liquor includes the following steps：
(1)：The Chinese medicine composition of formula ratio is taken to be positioned in non-metallic vessel, then to take the liquor made from sorghum of formula ratio to be positioned over non- It is uniformly mixed with Chinese medicine composition in metalware, non-metallic vessel is sealed, be put into native stove boiler, in 100 DEG C of conditions Lower distillation distills product in 12 hours to get mixing；
(2)：Will step (1) mixing distillation product weather exposure obtained 7 days to get；
Wherein, further include the pre- of Chinese medicine composition before Chinese medicine composition being positioned in non-metallic vessel in step (1) Processing step, specially：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned in extractor after cleaning Extracting in water three times, is added the water of Chinese medicine composition 9 times of weight of total weight, every time extraction 2.5 hours, merges each secondary medicine every time Liquid simultaneously filters, and obtains traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, is added after being warming up to 90 DEG C, 30 minutes Enter sodium bicarbonate and adjust pH value to 6.5, adds the complex enzyme of 10 parts by weight, digest 25 minutes, be cooled under the conditions of 80 DEG C 35 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, is kept for 8 minutes, is taken out, concentration is dry to powder, i.e., ；
Complex enzyme includes the glucuroide of the cellulase of 3 parts by weight, the pectase of 5 parts by weight and 3 parts by weight；
Further include flocculation step after step (1) mixing obtained is distilled product weather exposure 7 days in the step (2) Suddenly, specially：
a：The mixed flocculation agent of 3 parts by weight is positioned in container and is uniformly mixed, 100 times of mixed flocculation agent total weight is added The water of weight dilutes, and obtains mixed flocculation solution；
b：Medicinal liquor after weather exposure 7 days is placed and is stirred 10 minutes with 10 revs/min of speed at room temperature, by step Mixed flocculation solution made from a is instilled with the speed of 3 seconds/drop in medicinal liquor, continues stirring 20 minutes after being added dropwise, and it is small to stand 24 When after supernatant and precipitation, will mix with supernatant after precipitation filtering to get；
The mixed flocculation agent includes：The ZC-101 of the aluminium silicate polymer of 1 parts by weight, the bentonite of 1 parts by weight and 1 parts by weight Flocculant.
Embodiment 8
It is a kind of and to be in place of the difference of embodiment 2 for treating the medicinal liquor of rheumatism bone disease,
The preparation method of the medicinal liquor includes the following steps：
(1)：The Chinese medicine composition of formula ratio is taken to be positioned in non-metallic vessel, then to take the liquor made from sorghum of formula ratio to be positioned over non- It is uniformly mixed with Chinese medicine composition in metalware, non-metallic vessel is sealed, be put into native stove boiler, in 100 DEG C of conditions Lower distillation distills product in 12 hours to get mixing；
(2)：Will step (1) mixing distillation product weather exposure obtained 7 days to get；
Wherein, further include the pre- of Chinese medicine composition before Chinese medicine composition being positioned in non-metallic vessel in step (1) Processing step, specially：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned in extractor after cleaning Extracting in water three times, is added the water of Chinese medicine composition 9 times of weight of total weight, every time extraction 2.5 hours, merges each secondary medicine every time Liquid simultaneously filters, and obtains traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, is added after being warming up to 90 DEG C, 30 minutes Enter sodium bicarbonate and adjust pH value to 6.5, adds the complex enzyme of 10 parts by weight, digest 25 minutes, be cooled under the conditions of 80 DEG C 35 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, is kept for 8 minutes, is taken out, concentration is dry to powder, i.e., ；
Complex enzyme includes the glucuroide of the cellulase of 3 parts by weight, the pectase of 5 parts by weight and 3 parts by weight；
Further include flocculation step after step (1) mixing obtained is distilled product weather exposure 7 days in the step (2) Suddenly, specially：
a：The mixed flocculation agent of 7.5 parts by weight is positioned in container and is uniformly mixed, mixed flocculation agent total weight 125 is added The water dilution of times weight, obtains mixed flocculation solution；
b：Medicinal liquor after weather exposure 7 days is placed and is stirred 10 minutes with 15 revs/min of speed at room temperature, by step Mixed flocculation solution made from a is instilled with the speed of 4 seconds/drop in medicinal liquor, continues stirring 25 minutes after being added dropwise, and it is small to stand 24 When after supernatant and precipitation, will mix with supernatant after precipitation filtering to get；
The mixed flocculation agent includes：The ZC- of the aluminium silicate polymer of 3 parts by weight, the bentonite of 3 parts by weight and 1.5 parts by weight 101 flocculants.
Embodiment 9
It is a kind of and to be in place of the difference of embodiment 2 for treating the medicinal liquor of rheumatism bone disease,
The preparation method of the medicinal liquor includes the following steps：
(1)：The Chinese medicine composition of formula ratio is taken to be positioned in non-metallic vessel, then to take the liquor made from sorghum of formula ratio to be positioned over non- It is uniformly mixed with Chinese medicine composition in metalware, non-metallic vessel is sealed, be put into native stove boiler, in 100 DEG C of conditions Lower distillation distills product in 12 hours to get mixing；
(2)：Will step (1) mixing distillation product weather exposure obtained 7 days to get；
Wherein, further include the pre- of Chinese medicine composition before Chinese medicine composition being positioned in non-metallic vessel in step (1) Processing step, specially：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned in extractor after cleaning Extracting in water three times, is added the water of Chinese medicine composition 9 times of weight of total weight, every time extraction 2.5 hours, merges each secondary medicine every time Liquid simultaneously filters, and obtains traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, is added after being warming up to 90 DEG C, 30 minutes Enter sodium bicarbonate and adjust pH value to 6.5, adds the complex enzyme of 10 parts by weight, digest 25 minutes, be cooled under the conditions of 80 DEG C 35 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, is kept for 8 minutes, is taken out, concentration is dry to powder, i.e., ；
Complex enzyme includes the glucuroide of the cellulase of 3 parts by weight, the pectase of 5 parts by weight and 3 parts by weight；
Further include flocculation step after step (1) mixing obtained is distilled product weather exposure 7 days in the step (2) Suddenly, specially：
a：The mixed flocculation agent of 12 parts by weight is positioned in container and is uniformly mixed, mixed flocculation agent total weight 150 is added The water dilution of times weight, obtains mixed flocculation solution；
b：Medicinal liquor after weather exposure 7 days is placed and is stirred 10 minutes with 20 revs/min of speed at room temperature, by step Mixed flocculation solution made from a is instilled with the speed of 5 seconds/drop in medicinal liquor, continues stirring 30 minutes after being added dropwise, and it is small to stand 24 When after supernatant and precipitation, will mix with supernatant after precipitation filtering to get；
The mixed flocculation agent includes：The ZC-101 of the aluminium silicate polymer of 5 parts by weight, the bentonite of 5 parts by weight and 2 parts by weight Flocculant.
Reference examples 1
A kind of medicinal liquor for treating rheumatism bone disease, which includes the Chinese medicine composition and 15000 weight of 630 parts by weight The liquor made from sorghum of part, the Chinese medicine composition are prepared by the raw material of following parts by weight：
Wherein, liquor made from sorghum uses 60 ° of liquor made from sorghum.
Reference examples 2
A kind of medicinal liquor for treating rheumatism bone disease, which includes the Chinese medicine composition and 15000 weight of 495 parts by weight The liquor made from sorghum of part, the Chinese medicine composition are prepared by the raw material of following parts by weight：
Wherein, liquor made from sorghum uses 60 ° of liquor made from sorghum.
Reference examples 3
A kind of medicinal liquor for treating rheumatism bone disease, which includes the Chinese medicine composition and 5000 weight of 345 parts by weight The liquor made from sorghum of part, the Chinese medicine composition are prepared by the raw material of following parts by weight：
Wherein, the liquor made from sorghum that liquor made from sorghum is 60 °.
Reference examples 4
A kind of medicinal liquor for treating rheumatism bone disease, which includes the Chinese medicine composition and 5000 weight of 345 parts by weight The liquor made from sorghum of part, the Chinese medicine composition are prepared by the raw material of following parts by weight：
Wherein, the liquor made from sorghum that liquor made from sorghum is 60 °.
Reference examples 5
A kind of medicinal liquor for treating rheumatism bone disease, which includes the Chinese medicine composition and 15000 weight of 630 parts by weight The liquor made from sorghum of part, the Chinese medicine composition are prepared by the raw material of following parts by weight：
Wherein, aconiti preparata,radix and wild aconite root are all made of version in 2015《Chinese Pharmacopoeia》In concocting method process；
Wherein, liquor made from sorghum uses 60 ° of liquor made from sorghum.
Reference examples 6
A kind of medicinal liquor for treating rheumatism bone disease, which includes the Chinese medicine composition and 15000 weight of 630 parts by weight The liquor made from sorghum of part, the Chinese medicine composition are prepared by the raw material of following parts by weight：
Wherein, liquor made from sorghum uses 50 ° of liquor made from sorghum.
Reference examples 7
A kind of medicinal liquor for treating rheumatism bone disease, which includes the Chinese medicine composition and 15000 weight of 630 parts by weight The liquor made from sorghum of part, the Chinese medicine composition are prepared by the raw material of following parts by weight：
Wherein, liquor made from sorghum uses 60 ° of liquor made from sorghum；
The preparation method of the medicinal liquor is that the liquor made from sorghum of the Chinese medicine composition of formula ratio and formula ratio is positioned over glass container In be uniformly mixed, impregnate 20 days after to obtain the final product.
Reference examples 8
A kind of medicinal liquor for treating rheumatism bone disease is in place of the difference with embodiment 2, by Chinese medicine group in step (1) Further include the pre-treatment step of Chinese medicine composition, specially before conjunction object is positioned in non-metallic vessel：
Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned over after cleaning in extractor and is added water Extraction three times, is added the water of Chinese medicine composition 9 times of weight of total weight, every time extraction 2.5 hours, merges each secondary liquid simultaneously every time Filtering to get；
Wherein, complex enzyme includes the glucoside of the cellulase of 3 parts by weight, the pectase of 5 parts by weight and 3 parts by weight Enzyme.
Reference examples 9
A kind of medicinal liquor for treating rheumatism bone disease is in place of the difference with embodiment 2, by Chinese medicine group in step (1) Further include the pre-treatment step of Chinese medicine composition, specially before conjunction object is positioned in non-metallic vessel：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned in extractor after cleaning Extracting in water three times, is added the water of Chinese medicine composition 9 times of weight of total weight, every time extraction 2.5 hours, merges each secondary medicine every time Liquid simultaneously filters, and obtains traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, is added after being warming up to 90 DEG C, 30 minutes Enter sodium bicarbonate and adjust pH value to 6.5, adds the complex enzyme of 10 parts by weight, digest 25 minutes, be cooled under the conditions of 80 DEG C 35 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, is kept for 8 minutes, is taken out, concentration is dry to powder, i.e., ；
Wherein, complex enzyme includes the glucuroide of the pectase and 3 parts by weight of 8 parts by weight.
Reference examples 10
A kind of medicinal liquor for treating rheumatism bone disease is in place of the difference with embodiment 2, by Chinese medicine group in step (1) Further include the pre-treatment step of Chinese medicine composition, specially before conjunction object is positioned in non-metallic vessel：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned in extractor after cleaning Extracting in water three times, is added the water of Chinese medicine composition 9 times of weight of total weight, every time extraction 2.5 hours, merges each secondary medicine every time Liquid simultaneously filters, and obtains traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, is added after being warming up to 90 DEG C, 30 minutes Enter sodium bicarbonate and adjust pH value to 6.5, adds the complex enzyme of 10 parts by weight, digest 25 minutes, be cooled under the conditions of 80 DEG C 35 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, is kept for 8 minutes, is taken out, concentration is dry to powder, i.e., ；
Wherein, complex enzyme includes the glucuroide of 11 parts by weight.
Reference examples 11
A kind of medicinal liquor for treating rheumatism bone disease is in place of the difference with embodiment 2, by Chinese medicine group in step (1) Further include the pre-treatment step of Chinese medicine composition, specially before conjunction object is positioned in non-metallic vessel：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned in extractor after cleaning Extracting in water three times, is added the water of Chinese medicine composition 9 times of weight of total weight, every time extraction 2.5 hours, merges each secondary medicine every time Liquid simultaneously filters, and obtains traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, is added after being warming up to 90 DEG C, 30 minutes Enter sodium bicarbonate and adjust pH value to 6.5, adds the complex enzyme of 10 parts by weight, digest 25 minutes, be cooled under the conditions of 80 DEG C 35 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, is kept for 8 minutes, is taken out, concentration is dry to powder, i.e., ；
Wherein, complex enzyme includes the glucuroide of the amylase of 3 parts by weight, the pectase of 5 parts by weight and 3 parts by weight.
Reference examples 12
A kind of medicinal liquor for treating rheumatism bone disease is, the preparation method of the medicinal liquor in place of the difference with embodiment 2 Include the following steps：
(1)：The Chinese medicine composition of formula ratio is taken to be positioned in non-metallic vessel, then to take the liquor made from sorghum of formula ratio to be positioned over non- It is uniformly mixed with Chinese medicine composition in metalware, non-metallic vessel is sealed, be put into native stove boiler, in 100 DEG C of conditions Lower distillation distills product in 12 hours to get mixing；
(2)：Will step (1) mixing distillation product weather exposure obtained 7 days to get；
Wherein, further include the pre- of Chinese medicine composition before Chinese medicine composition being positioned in non-metallic vessel in step (1) Processing step, specially：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned in extractor after cleaning Extracting in water three times, is added the water of Chinese medicine composition 9 times of weight of total weight, every time extraction 2.5 hours, merges each secondary medicine every time Liquid simultaneously filters, and obtains traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, is added after being warming up to 90 DEG C, 30 minutes Enter sodium bicarbonate and adjust pH value to 6.5, adds the complex enzyme of 10 parts by weight, digest 25 minutes, be cooled under the conditions of 80 DEG C 35 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, is kept for 8 minutes, is taken out, concentration is dry to powder, i.e., ；
Complex enzyme includes the glucuroide of the cellulase of 3 parts by weight, the pectase of 5 parts by weight and 3 parts by weight；
Further include flocculation step after step (1) mixing obtained is distilled product weather exposure 7 days in the step (2) Suddenly, specially：
The mixed flocculation agent of formula ratio is directly added into medicinal liquor and is stirred 25 minutes, supernatant is obtained after standing 24 hours and is sunk Form sediment, will mix with supernatant after precipitation filtering to get；
The mixed flocculation agent includes：The ZC- of the aluminium silicate polymer of 3 parts by weight, the bentonite of 3 parts by weight and 1.5 parts by weight 101 flocculants.
Reference examples 13
A kind of medicinal liquor for treating rheumatism bone disease is, the preparation method of the medicinal liquor in place of the difference with embodiment 2 Include the following steps：
(1)：The Chinese medicine composition of formula ratio is taken to be positioned in non-metallic vessel, then to take the liquor made from sorghum of formula ratio to be positioned over non- It is uniformly mixed with Chinese medicine composition in metalware, non-metallic vessel is sealed, be put into native stove boiler, in 100 DEG C of conditions Lower distillation distills product in 12 hours to get mixing；
(2)：Will step (1) mixing distillation product weather exposure obtained 7 days to get；
Wherein, further include the pre- of Chinese medicine composition before Chinese medicine composition being positioned in non-metallic vessel in step (1) Processing step, specially：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned in extractor after cleaning Extracting in water three times, is added the water of Chinese medicine composition 9 times of weight of total weight, every time extraction 2.5 hours, merges each secondary medicine every time Liquid simultaneously filters, and obtains traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, is added after being warming up to 90 DEG C, 30 minutes Enter sodium bicarbonate and adjust pH value to 6.5, adds the complex enzyme of 10 parts by weight, digest 25 minutes, be cooled under the conditions of 80 DEG C 35 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, is kept for 8 minutes, is taken out, concentration is dry to powder, i.e., ；
Complex enzyme includes the glucuroide of the cellulase of 3 parts by weight, the pectase of 5 parts by weight and 3 parts by weight；
Further include flocculation step after step (1) mixing obtained is distilled product weather exposure 7 days in the step (2) Suddenly, specially：
a：The mixed flocculation agent of 7.5 parts by weight is positioned in container and is uniformly mixed, mixed flocculation agent total weight 125 is added The water dilution of times weight, obtains mixed flocculation solution；
b：Medicinal liquor after weather exposure 7 days is placed and is stirred at room temperature with 10 revs/min of speed, after five minutes, will be walked Mixed flocculation solution made from rapid a is instilled with the speed of 10 seconds/drop in medicinal liquor, continues stirring 25 minutes after being added dropwise, and is stood After 12 hours supernatant and precipitation, will mix with supernatant after precipitation filtering to get；
The mixed flocculation agent includes：The ZC- of the aluminium silicate polymer of 3 parts by weight, the bentonite of 3 parts by weight and 1.5 parts by weight 101 flocculants.
Reference examples 14
A kind of medicinal liquor for treating rheumatism bone disease is, the preparation method of the medicinal liquor in place of the difference with embodiment 2 Include the following steps：
(1)：The Chinese medicine composition of formula ratio is taken to be positioned in non-metallic vessel, then to take the liquor made from sorghum of formula ratio to be positioned over non- It is uniformly mixed with Chinese medicine composition in metalware, non-metallic vessel is sealed, be put into native stove boiler, in 100 DEG C of conditions Lower distillation distills product in 12 hours to get mixing；
(2)：Will step (1) mixing distillation product weather exposure obtained 7 days to get；
Wherein, further include the pre- of Chinese medicine composition before Chinese medicine composition being positioned in non-metallic vessel in step (1) Processing step, specially：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned in extractor after cleaning Extracting in water three times, is added the water of Chinese medicine composition 9 times of weight of total weight, every time extraction 2.5 hours, merges each secondary medicine every time Liquid simultaneously filters, and obtains traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, is added after being warming up to 90 DEG C, 30 minutes Enter sodium bicarbonate and adjust pH value to 6.5, adds the complex enzyme of 10 parts by weight, digest 25 minutes, be cooled under the conditions of 80 DEG C 35 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, is kept for 8 minutes, is taken out, concentration is dry to powder, i.e., ；
Complex enzyme includes the glucuroide of the cellulase of 3 parts by weight, the pectase of 5 parts by weight and 3 parts by weight；
Further include flocculation step after step (1) mixing obtained is distilled product weather exposure 7 days in the step (2) Suddenly, specially：
a：The mixed flocculation agent of 7.5 parts by weight is positioned in container and is uniformly mixed, mixed flocculation agent total weight 125 is added The water dilution of times weight, obtains mixed flocculation solution；
b：Medicinal liquor after weather exposure 7 days is placed and is stirred 10 minutes with 15 revs/min of speed at room temperature, by step Mixed flocculation solution made from a is instilled with the speed of 4 seconds/drop in medicinal liquor, continues stirring 25 minutes after being added dropwise, and it is small to stand 24 When after supernatant and precipitation, will mix with supernatant after precipitation filtering to get；
The mixed flocculation agent includes：The ZC- of the aluminium silicate polymer of 3 parts by weight, the chitosan of 3 parts by weight and 1.5 parts by weight 101 flocculants.
Reference examples 15
A kind of medicinal liquor for treating rheumatism bone disease is, the preparation method of the medicinal liquor in place of the difference with embodiment 2 Include the following steps：
(1)：The Chinese medicine composition of formula ratio is taken to be positioned in non-metallic vessel, then to take the liquor made from sorghum of formula ratio to be positioned over non- It is uniformly mixed with Chinese medicine composition in metalware, non-metallic vessel is sealed, be put into native stove boiler, in 100 DEG C of conditions Lower distillation distills product in 12 hours to get mixing；
(2)：Will step (1) mixing distillation product weather exposure obtained 7 days to get；
Wherein, further include the pre- of Chinese medicine composition before Chinese medicine composition being positioned in non-metallic vessel in step (1) Processing step, specially：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned in extractor after cleaning Extracting in water three times, is added the water of Chinese medicine composition 9 times of weight of total weight, every time extraction 2.5 hours, merges each secondary medicine every time Liquid simultaneously filters, and obtains traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, is added after being warming up to 90 DEG C, 30 minutes Enter sodium bicarbonate and adjust pH value to 6.5, adds the complex enzyme of 10 parts by weight, digest 25 minutes, be cooled under the conditions of 80 DEG C 35 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, is kept for 8 minutes, is taken out, concentration is dry to powder, i.e., ；
Complex enzyme includes the glucuroide of the cellulase of 3 parts by weight, the pectase of 5 parts by weight and 3 parts by weight；
Further include flocculation step after step (1) mixing obtained is distilled product weather exposure 7 days in the step (2) Suddenly, specially：
a：The mixed flocculation agent of 7.5 parts by weight is positioned in container and is uniformly mixed, mixed flocculation agent total weight 125 is added The water dilution of times weight, obtains mixed flocculation solution；
b：Medicinal liquor after weather exposure 7 days is placed and is stirred 10 minutes with 15 revs/min of speed at room temperature, by step Mixed flocculation solution made from a is instilled with the speed of 4 seconds/drop in medicinal liquor, continues stirring 25 minutes after being added dropwise, and it is small to stand 24 When after supernatant and precipitation, will mix with supernatant after precipitation filtering to get；
The mixed flocculation agent is the bentonite of 7.5 parts by weight.
Therapeutic effect of the test example 1 to rheumatic arthritis
1.1 animal model
Initial immunity：130 rats are taken, with 2% Nembutal sodium solution intraperitoneal injection of anesthesia rat (0.3mL/ only), in 0.12mL collagen emulsions (240 μ g containing collagen) are subcutaneously injected in every rat root of the tail portion；Excitation is immune：After initial immunity the 7th day in 0.03mL collagen emulsions (120 μ g containing collagen altogether) are respectively subcutaneously injected in rat stern back both sides.
1.2 medication
110 rats are randomly divided into 1 group of model, experiment 1-4 groups, control 1-7 groups and positive group, positive group uses the patent No. For the CN105106832A treatment rheumatic prepared and the stupid numbness wine of rheumatoid arthritis rheumatism, every group 10,10 are separately taken For the rat of non-modeling as blank group, experiment 1-4 groups give the medicinal liquor of embodiment 1-4 respectively, and control 1-7 groups are given respectively to be compareed The medicinal liquor of example 1-7, medication are gastric infusion, and dosage is 1mL/ days/, is administered 28 days altogether, 1 group of model and blank group are given The same dose of water are given, each group rat extremities joint inflammatory score and vola thickness is recorded, the results are shown in Table 1.
Arthritis standards of grading：1 point-slight ankle-joint redness or individual toe joint swellings；The ankle of 2 points-moderate closes Section is red and swollen；3 points-entire sufficient pawl (including toe joint) is serious red and swollen；The serious red and swollen multiple joints of accumulation of 4 points-limbs, joint motion It is limited.
1 each group medicinal liquor of table scores rat articular inflammation and the influence of vola thickness
1.3 conclusion
As shown in Table 1, the medicinal liquor that 1-4 of the embodiment of the present invention is provided there is apparent inhibition to make the inflammation of modeling rat With vola thickness can be substantially reduced, and effect illustrates provided by the invention better than the medicinal liquor of reference examples 1-7 and positive group Good synergistic effect can be played between Chinese medicine composition and 60 ° of liquor made from sorghums, there is significant treatment to rheumatic arthritis Effect, when changing any ingredient or concocting method in medicinal liquor provided by the invention, to the therapeutic effect of rheumatic arthritis Can it decline.
Therapeutic effect of the test example 2 to rheumatoid arthritis
2.1 animal model
Before taking 130 rat modelings, first adaptability raising animal 1 week using 5% chloraldurate intraperitoneal anesthesia, routinely disappears Skin of sole of foot after malicious Rat Right, point 3 points of hypodermic injection 0.1mL Freund's complete adjuvant modelings, is observed 3 days, big after modeling success There is acute inflammatory response swelling in mouse foot in for 24 hours, secondary whole body polyarthirtis in 48h, show rat forelimb performance or There is obvious tumefaction in side limb, and inflammatory tubercle occur in ear, tail portion.
2.2 test method
130 rats after a week, are divided into experiment 5-8 groups, control 8-14 groups, 2 groups of model and the positive by modeling success respectively Group, positive group is using the Patent No. CN105106832A treatment rheumatic prepared and the stupid numbness of rheumatoid arthritis rheumatism Wine, every group 10, experiment 5-8 groups give the medicinal liquor of embodiment 1-4 respectively, and control 8-14 groups give the medicine of reference examples 1-7 respectively Wine, medication are gastric infusion, and dosage is 1mL/ days/, is treated 5 weeks altogether, 2 groups of model and blank group are given on an equal basis The water of dosage, before modeling, modeling one week, modeling three weeks, modeling detection each group Rat Right metapedes foot plantar swelling in five weeks Degree, fixed rat are goed deep into rat hindlimb, including ball portion under liquid level, using cuvette cartridge suitable quantity of water with a scale under shin bone It holds and is used as anatomic landmark point at internal malleolus, the numerical value that the record each group rat water surface rises, as rat paw edema degree, modeling five After week, using 5% chloraldurate intraperitoneal injection of anesthesia rat, each group rat 2mL abdominal aorta blood is taken, serum is detached, adopts It is dual anti-with automatic clinical chemistry analyzer detection each group rat blood serum immunoglobulin level, including lgG, lgA and lgM, use The sandwich ABC-ELISA methods detection each group rat blood serum IL-1 of body and TNF-α are horizontal, the results are shown in Table 2 and table 3.
2 different time each group rat red swollen feet degree of table compares
3 each group rat blood serum 1L-1 of table, TNF-α level compare
2.3 conclusion
By table 2 and table 3 it is found that the medicinal liquor that 1-4 of the embodiment of the present invention is provided can significantly inhibit the red swollen feet of rat Degree, while the level of IL-1 and TNF-α can be reduced, and the medicinal liquor better than reference examples 1-7 and positive group with obvious effects, it says Good synergistic effect can be played between bright Chinese medicine composition provided by the invention and 60 ° of liquor made from sorghums, to rheumatoid joint Inflammation has significant therapeutic effect, when changing any ingredient or concocting method in medicinal liquor provided by the invention, to rheumatoid The arthritic therapeutic effect of property can decline, and when being especially changed to the concocting method of monkshood or radix aconiti agrestis, can greatly drop Therapeutic effect of the low medicinal liquor provided by the invention to rheumatoid arthritis.
Therapeutic effect of the test example 3 to osteoproliferation pain
It is 22-26 grams of Female ICR mice 100 to take weight, is randomly divided into 3 groups of model, experiment 9-12 groups, control 15- 18 groups and positive group, positive group is using the Patent No. CN105106832A treatment rheumatic prepared and rheumatoid arthritis numbness The stupid numbness wine of disease, experiment 9-12 groups give the medicinal liquor of embodiment 3-6, and control 15-18 groups give the medicinal liquor of reference examples 8-11, every group 10, analgesic effect is evaluated with hot plate stimulus method, first measures the normal of every mouse respectively with hot plate pain threshold detector device (55.5 DEG C) Pain threshold was administered once daily, and is given 1mL/ times every time, continuous to give two days, in 30 minutes after the last administration, 60 minutes, 120 minutes When measure the threshold of pain time, the results are shown in Table 4.
The analgesic activity that 4 each group medicinal liquor of table tests mouse hot-plate
As shown in Table 4, the medicinal liquor that 3-6 of the embodiment of the present invention is provided can significantly extend the threshold of pain time of rat, and two Still there are apparent analgesic activity, the medicinal liquor and positive drug better than reference examples 8-11 with obvious effects to illustrate this hair after hour Good synergistic effect can be played between the Chinese medicine composition of bright offer and 60 ° of liquor made from sorghums, is had to osteoproliferation pain aobvious The remission effect of work, when deleting enzymolysis step or being changed to the parameter of enzymolysis step, the treatment to osteoproliferation pain Effect can decline, and the effect that embodiment 4-6 extends the Pain Regulation In The Rat time is better than embodiment 3, it was demonstrated that add in preparation method The threshold of pain time of rat can greatly be extended by entering enzymolysis step, and then preferably alleviate the osteoproliferation pain of rat.
Therapeutic effect of the test example 4 to scapulohumeral periarthritis
Healthy rat is taken, weight 180-200g, 140, half male and half female is divided into experiment 13-16 groups, control 19-25 groups, mould 4 groups of type, blank group and positive group, positive group is using the Patent No. CN105106832A treatment rheumatic prepared and rheumatoid The stupid numbness wine of arthritis rheumatism, experiment 13-16 groups give the medicinal liquor of embodiment 1-4, and control 19-25 groups give reference examples 1-7's Medicinal liquor, every group 10, successive administration 14 days, daily 1mL/ days/only, and the 0.5%CMC of 4 groups of blank group and model to equivalent, administration The the 13rd, 14 day, in addition to blank group, remaining rat by 1mg/kg be subcutaneously injected adrenalin hydrochloride, 2 times/day, for the first time inject 2h puts animal in 4 DEG C of ice water 15 minutes into afterwards, and administration takes 4-5mL blood anticoagulant heparins to measure blood rheology parameter on the 15th day, It the results are shown in Table 5.
Influence of the 5 each group drug of table to rat blood stasis models hemorheology
As shown in Table 5, the medicinal liquor that 1-4 of the embodiment of the present invention is provided is equal to the improvement of the hemorheology index of rat Higher than the medicinal liquor of reference examples 1-7, illustrate that between Chinese medicine composition provided by the invention and 60 ° of liquor made from sorghums good association can be played Same-action has significant therapeutic effect to scapulohumeral periarthritis, when changing any ingredient or processing side in medicinal liquor provided by the invention When method, the therapeutic effect of scapulohumeral periarthritis can be declined.
Therapeutic effect of the test example 5 to cervical spondylosis
5.1 modeling：
90 rats are taken, rat is anaesthetized with 10% chloraldurate solution, fixes rat prone position after anesthesia, with Hand touch down neck nearby highest spinous process (T2) central point, the hair of rat neck and upper back is shaved only, after routine disinfection, thus to On in back median line do 3cm or so notch, successively blunt separation subcutaneous tissue, nape muscle group (reduce to the greatest extent to muscle groups The extensive damage knitted), until cone bow fully exposure on the left of C6-T2, shaves the tissues such as its surface muscle and ligament, uses microforceps C7 and T1 are gently chosen out, the ligamentum flavum and connective tissue of C6 and C7 intervertenral spaces are gently clamped with sharp mouth mosquito forceps and open cone bow on the left of C7, Exposing spinal cord is touched spinal cord to right side with ophthalmology nerve dissector, then with microsurgery tweezer will about 1.5cm long, diameter The nylon fishing line of 0.5mm is gently put along longitudinal spinal cord axis to C6, C7, T1 nerve root oxter, and wound is finally successively closed, and suture is It can.
5.2 method：
Rat is divided into experiment 17-19 groups, control 26-28 groups, 5 groups of model and positive controls, every group 10, modeling at Gastric infusion after work(, takes 10 non-modeling rats to do blank, and experiment 17-19 groups give the medicinal liquor of embodiment 1-3, compare 26-28 Group gives the medicinal liquor of reference examples 5-7, the treatment rheumatic and rheumatoid that positive group is prepared using Patent No. CN105106832A Property the stupid numbness wine of arthritis rheumatism, it is 1mL/ days/that 5 groups of blank group and model, which give isodose water, dosage, is continuously given Medicine 7 days puts to death rat respectively, takes out crimping section backbone, raises back side cone-plate, selects and is less than 0.5cm × 0.5cm × 0.1cm groups Block is knitted, sclerotin and muscular components paraffin embedding around spinal cord and nerve root are peelled off after 4% paraformaldehyde is fixed, in ridge 5 μ m-thick serial section are done at the position that marrow sends out Holy Bible root, are all made of immunohistochemistrySABC SABC decoration method and are carried out immune ball respectively Albumen (Ig) G is dyed, and is carried out JAK1, STAT3 immunohistochemistry and is measured, the results are shown in Table 6.
Expression of the 6 each group medicinal liquor of table to spinal cord at rat crimping and neural root tissue JAK1, STAT3
5.3 conclusion
As shown in Table 6, rat takes significantly low to the expression of JAK1 and STST3 after the medicinal liquor of 1-3 of the embodiment of the present invention In model group and reference examples 5-7, illustrate that medicinal liquor provided by the invention and preparation method thereof there is significant treatment to imitate cervical spondylosis Fruit, it is equal to the therapeutic effect of cervical spondylosis when the preparation method for changing any ingredient or medicinal liquor in medicinal liquor provided by the invention It can decline, and the medicinal liquor of embodiment 2-3 is substantially less than embodiment 1 to the expression of JAK1 and STST3, it was demonstrated that it is provided by the invention The preparation method of medicinal liquor has preferable therapeutic effect to cervical spondylosis.
6 clarity of test example is tested
Example 7-9 and reference examples 12-15 medicinal liquor, 4 judging panels observe this 7 groups of medicinal liquor and give a mark to it respectively, Scoring criterion is：1 point-clarity it is very poor and have precipitation, 2 points-have turbid phenomenon, 3 points-slight turbid, 4 points-completely it is clear and bright；It is real It tests and the results are shown in Table 7.
Table 7 is used to treat the clarity appraisal result of the medicinal liquor of rheumatism bone disease
As shown in Table 7, the clarity of the medicinal liquor of embodiment 7-9 is completely clear and bright, is considerably better than reference examples 12-15, it was demonstrated that Preparation method provided by the invention can greatly improve the clarity of medicinal liquor, the mixed flocculation in deletion or the replacement present invention When constituent in agent, the clarity of medicinal liquor can be reduced.
Classical case
1. Korea Spro so-and-so, man, 32 years old, Lianyungang of Jiangsu people suffered from rheumatic arthritis in 1912, is paralyzed in bed 3 years, life not It can take care of oneself, its rear wife seeks great grandfather Han Xiansheng, seeks tcm therapy treatment, and because of patient's three over-carriages of bed, worn to a shadow, cold-dampness is become silted up solidifying Weight, family's poverty are cured without money, are just cured, are taken three times a day, every time five money with this prescription medicinal liquor, after taking March, trick toe Can be movable, after taking June, leg can be movable, and energy sitting, taking 12 months can leave the bed, and firmly crutch moves, and take 16 months after capable of going slowly, because Family's difficulty is compeled, i.e., work of being engaged in agriculture down perfects labor and does to more than 80 years old and passes away after withdrawing.
2. Yang, female, 22 years old, Lianyungang of Jiangsu people, in December, 2011 suffered from rheumatic arthritis, is students, entirely Body pain, fingers deformed are in hook, can't take care of oneself, cannot hold a pen, and cannot take any article, and wearing the clothes to have a meal all needs others to help It helps, it is big to the huge stress of family's band, take this prescription medicinal liquor 30 days, you can oneself wear the clothes and have a meal.It takes three months, walks Freely.It takes six months, just returns correction and often attend class, rear clothes were consolidated to 12 months, recovery from illness.So far normal study and work.

Claims (9)

1. a kind of medicinal liquor for treating rheumatism bone disease, which is characterized in that the main Chinese medicine composition for including 345-928 parts by weight With the liquor made from sorghum of 5000-30000 parts by weight, the Chinese medicine composition is prepared by the raw material of following parts by weight：
The liquor made from sorghum that the liquor made from sorghum is 55 ° -60 °.
2. the medicinal liquor as described in claim 1 for treating rheumatism bone disease, which is characterized in that main includes 630 parts by weight The liquor made from sorghum of Chinese medicine composition and 15000 parts by weight, the Chinese medicine composition are prepared by the raw material of following parts by weight：
The liquor made from sorghum that the liquor made from sorghum is 60 °.
3. the medicinal liquor as claimed in claim 1 or 2 for treating rheumatism bone disease, which is characterized in that the aconiti preparata,radix is will to give birth to Monkshood processes, and the wild aconite root is to process Radix Aconiti Kusnezoffii, and the concocting method of the aconiti preparata,radix and wild aconite root is specially：
The concocting method of aconiti preparata,radix：By Radix Aconiti under the conditions of 100 DEG C frying 20-30min, the then Radix Aconiti after frying The rice vinegar that 0.1-0.5 times of weight is sprayed on surface continues frying 5-10min to get aconiti preparata,radix；
The concocting method of wild aconite root：By Radix Aconiti Kusnezoffii under the conditions of 100 DEG C frying 20-30min, the then Radix Aconiti Kusnezoffii after frying The rice vinegar that 0.1-0.5 times of weight is sprayed on surface continues frying 5-10min to get wild aconite root.
4. preparing the method as claimed in claim 1 or 2 for treating the medicinal liquor of rheumatism bone disease, which is characterized in that the method Include the following steps：
(1)：The Chinese medicine composition of formula ratio is taken to be positioned in non-metallic vessel, then to take the liquor made from sorghum of formula ratio to be positioned over nonmetallic It is uniformly mixed with Chinese medicine composition in vessel, non-metallic vessel is sealed, be put into native stove boiler, steamed under the conditions of 100 DEG C It evaporates 12-24 hours and distills product to get mixing；
(2)：Will step (1) mixing distillation product weather exposure obtained 7-15 days to get.
5. the method as claimed in claim 3 for preparing the medicinal liquor for treating rheumatism bone disease, which is characterized in that in step (1) Further include the pre-treatment step of Chinese medicine composition, specially before Chinese medicine composition is positioned in non-metallic vessel：
S1：Each raw material in Chinese medicine composition is weighed according to formula ratio and is uniformly mixed, and is positioned over after cleaning in extractor and is added water Extraction three times, is added the water of Chinese medicine composition 8-10 times of weight of total weight, every time extraction 2-3 hours, merges each secondary medicine every time Liquid simultaneously filters, and obtains traditional Chinese medicine composition extract liquid；
S2：Traditional Chinese medicine composition extract liquid made from step S1 is positioned in preparing tank, is warming up to 80-100 DEG C, after 20-30min Sodium bicarbonate is added and adjusts pH value to 6.5, adds the complex enzyme of 1-20 parts by weight, 20-30min is digested under the conditions of 80 DEG C, It is cooled to 30-40 DEG C, enzymolysis liquid is made；
S3：Enzymolysis liquid made from step S2 is warming up to 100 DEG C, keeps 5-10min, is taken out, concentration, it is dry to powder to get.
6. the method as claimed in claim 5 for preparing the medicinal liquor for treating rheumatism bone disease, which is characterized in that the complex enzyme The glucuroide of the pectase and 0.3-5 parts by weight of cellulase, 0.5-10 parts by weight including 0.2-5 parts by weight.
7. the method as claimed in claim 3 for preparing the medicinal liquor for treating rheumatism bone disease, which is characterized in that the step (2) further include flocculation step, specially after step (1) mixing obtained is distilled product weather exposure 7-15 days in：
a：The mixed flocculation agent of 3-12 parts by weight is positioned in container and is uniformly mixed, mixed flocculation agent total weight 100- is added The water dilution of 150 times of weight, obtains mixed flocculation solution；
b：Medicinal liquor after weather exposure 7-15 days is placed and is stirred 10 minutes with 10-20 revs/min of speed at room temperature, will be walked Mixed flocculation solution is instilled with the speed of 3-5 seconds/drop in medicinal liquor made from rapid a, continues to stir 20-30min after being added dropwise, quiet After setting 24 hours supernatant and precipitation, will mix with supernatant after precipitation filtering to get.
8. the method as claimed in claim 7 for preparing the medicinal liquor for treating rheumatism bone disease, which is characterized in that the mixing wadding Solidifying agent includes the ZC-101 flocculants of the aluminium silicate polymer of 1-5 parts by weight, the bentonite of 1-5 parts by weight and 1-2 parts by weight.
9. the medicinal liquor as claimed in claim 1 or 2 for treating rheumatism bone disease is in preparing the product for treating rheumatism bone disease Application.
CN201810414112.XA 2018-05-03 2018-05-03 It is a kind of to be used to treat medicinal liquor of rheumatism bone disease and preparation method thereof Pending CN108310152A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109260353A (en) * 2018-11-16 2019-01-25 潘跃强 A kind of Chinese medicine composition and its preparation and preparation method for treating muscle and bone ache

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1051712C (en) * 1995-11-21 2000-04-26 郑教豪 Medicine for rheumatism
CN101972453A (en) * 2010-10-29 2011-02-16 韩世昌 Chinese medicinal liquor for treating rheumatic and rheumatoid arthritis and preparation method thereof
CN107057997A (en) * 2017-06-15 2017-08-18 孝感市亦泓家居创意设计有限公司 A kind of mulberry medicinal liquor and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1051712C (en) * 1995-11-21 2000-04-26 郑教豪 Medicine for rheumatism
CN101972453A (en) * 2010-10-29 2011-02-16 韩世昌 Chinese medicinal liquor for treating rheumatic and rheumatoid arthritis and preparation method thereof
CN107057997A (en) * 2017-06-15 2017-08-18 孝感市亦泓家居创意设计有限公司 A kind of mulberry medicinal liquor and preparation method thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
吕侠卿: "《中药传统制剂及零售经营知识》", 30 April 2007, 湖南科学技术出版社 *
张晓峰: "《全国医药院校高职高专规划教材 中药炮制技术》", 31 May 2012, 人民军医出版 *
李永康等: "两乌酒治疗痛痹型坐骨神经痛的疗效观察", 《浙江中医药大学学报》 *
田时志等: "温针灸对类风湿性关节炎大鼠血清免疫球蛋白、IL-1、TNF-α的影响", 《云南中医学院学报》 *
粟胜勇等: "不同灸量麦粒灸对神经根型颈椎病模型大鼠JAK1、STAT3的影响", 《中国老年学杂志》 *
罗永明: "《中药化学成分提取分离技术与方法》", 31 January 2016, 上海科学技术出版社 *
郑德柱等: "风湿性关节炎的辨证治疗体会 ", 《现代中西医结合杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109260353A (en) * 2018-11-16 2019-01-25 潘跃强 A kind of Chinese medicine composition and its preparation and preparation method for treating muscle and bone ache

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Application publication date: 20180724