CN108671195A - A kind of Chinese medicine composition and preparation for treatment of arthritis - Google Patents
A kind of Chinese medicine composition and preparation for treatment of arthritis Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
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- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract
The present invention relates to technical field of traditional Chinese medicines, specifically disclose a kind of Chinese medicine composition and preparation for treatment of arthritis, include the raw material of following weight：15 25 parts of pawpaw, 15 25 parts of lopseed, 10 20 parts of turmeric, 15 25 parts of Herba Lycopi, 15 25 parts of caulis piperis futokadsurae, 10 20 parts of aconiti preparata,radix, 10 20 parts of cortex acanthopanacis, 10 20 parts of Radix Angelicae Sinensis, 10 20 parts of safflower, 15 25 parts of folium artemisiae argyi, 15 25 parts of erythrina bark, 10 20 parts of wild aconite root, 15 25 parts of lycopodium calvatum, 10 20 parts of cassia twig, 15 25 parts of the root of Chinese clematis, 15 25 parts of rhizoma homalonemae, 5 15 parts of asarum, 15 25 parts of Rhizoma Chuanxiong；For most of eligible patients, it is only necessary to which 26 packet medicaments of the course for the treatment of can fully recover, and treatment cost is low, and each group patent medicine has good analgesia and Li Shui effects while treatment of arthritis in side.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition and preparation for treatment of arthritis.
Background technology
Rheumatic arthritis is a kind of common acute or chronic connective tissue inflammation.Recurrent exerbation and heart can be involved.
Clinic is characterized by the migrans miserable, heavily write in joint and muscle, pain.Belong to allergic disease.It is the main table of rheumatic fever
It is one of existing, mostly with febris acuta and arthralgia onset.
Rheumatoid arthritis is a kind of autoimmune disease based on chronic progressive arthropathy, symmetry it is more
Arthritis is involved most common with both hands, wrist, elbow, knee, ankle and podarthrum.Simultaneously patient can with fever, anaemia, subcutaneous nodule,
The extra-articular manifestations such as vasculitis, pericarditis and enlargement of lymph nodes, in serum can there are many autoantibodies, without the class correctly treated
Rheumathritis can be repeatedly breaking-out, delay for many years, eventually lead to the dysarthrasises such as late period finger, bowl, elbow, knee, ankle and function
It loses, hand X-ray film is shown in osteoporosis, damage of articular surface and arthrostenosis.
Bones and joints illness be one group of retrogression pathological changes, be due to increase age, obesity, strain, wound, joint birth defect,
Articular cartilage degeneration damage, joint margins and subchondral bone reactive hyperplasia, also known as bone caused by the factors such as joint deformity
Arthropathy, degenerative arthritis, senescent arthritis, hypertrophiarthritis etc..Clinical manifestation be the arthralgia slowly developed,
Tenderness, stiff, arthroncus, limitation of activity and joint deformity etc..
Currently, multiple phenomenon is presented in the illnesss such as rheumatism, rheumatoid arthritis, Bones and joints illness, moreover, with motorcycle,
The vehicles such as electric vehicle use universal, and age of onset is in the situation for tending to rejuvenation.It is one group of threat human life and shadow
Ring the great illness group of human life quality.It is badly in need of a kind of good effect, drug easy to use to treat them.
Chinese medicine refers to traditional Chinese medicine, is one of diagnosis and prevention for studying Human Physiology, pathology and disease etc.
Subject.It carries the experience and knowwhy that the ancient Chinese people struggle with disease, be the simple in ancient times materialism and
Under spontaneous Theories thought guidance, the theory of medicine system for gradually forming and developing into is put into practice by long term medical.It is studying
In method, with Overall View, similar sight for dominant ideas, based on the physiology of zang-fu differentiation, pathology, using diagnosis and treatment as diagnosis and treatment
Foundation has simple systematology, cybernetics, Fractal Theory and information theory content.
The positive face of Chinese traditional treatment is to wish to assist to restore the equilibrium between yin and yang of human body, and downside is then desirable to work as
When must be using deterioration of the drug to slow down disease, moreover it is possible to take into account life and the quality of life.
Chinese medicine is of extensive knowledge and profound scholarship, embraces a wide spectrum of ideas, most diseases can be found from Chinese medicine effective treatment method and
Therapy approach.Especially some chronic diseases, difficult and complicated cases, compared with western medicine, Chinese medicine more have impayable advantage and
Experience.
Invention content
Overcome the deficiencies in the prior art of the present invention, the technical problem to be solved is that a kind of Chinese medicines for treatment of arthritis
Composition and preparation.
In order to solve the above technical problems, the technical solution adopted in the present invention is：A kind of Chinese medicine for treatment of arthritis
Composition and preparation include the raw material of following weight：15-25 parts of pawpaw, 15-25 parts of lopseed, 10-20 parts of turmeric,
15-25 parts of Herba Lycopi, 15-25 parts of caulis piperis futokadsurae, 10-20 parts of aconiti preparata,radix, 10-20 parts of cortex acanthopanacis, 10-20 parts of Radix Angelicae Sinensis, safflower 10-20
Part, 15-25 parts of folium artemisiae argyi, 15-25 parts of erythrina bark, 10-20 parts of wild aconite root, 15-25 parts of lycopodium calvatum, 10-20 parts of cassia twig, the root of Chinese clematis
15-25 parts, 15-25 parts of rhizoma homalonemae, 5-15 parts of asarum, 15-25 parts of Rhizoma Chuanxiong.
Preferably, a kind of Chinese medicine composition and preparation for treatment of arthritis, includes the raw material of following weight：
20 parts of pawpaw, 20 parts of lopseed, 15 parts of turmeric, 20 parts of Herba Lycopi, 20 parts of caulis piperis futokadsurae, 15 parts of aconiti preparata,radix, 15 parts of cortex acanthopanacis, Radix Angelicae Sinensis 15
Part, 15 parts of safflower, 20 parts of folium artemisiae argyi, 20 parts of erythrina bark, 15 parts of wild aconite root, 20 parts of lycopodium calvatum, 15 parts of cassia twig, 20 parts of the root of Chinese clematis, thousand
Years strong 20 parts, 10 parts of asarum, 20 parts of Rhizoma Chuanxiong.
Compatibility parsing of the present invention is as follows：
Monarch drug in a prescription：It is the drug for playing primary treatment for main disease or main symptom.It is indispensable first of in its efficacy of a drug side of residence
Drug.Monarch drug in a prescription is preferably few, and general only with simply, if state of an illness complexity can use two tastes, but monarch drug in a prescription flavour of a drug should not be excessive, at most the efficacy of a drug point
It dissipates.
Monarch drug in a prescription rhizoma homalonemae of the present invention, erythrina bark.
Rhizoma homalonemae is warm-natured, bitter, pungent, returns liver and kidney channel, can wind-damp dispelling, strengthen the bone, be used for wind-cold-dampness arthralgia, waist and knee crymodynia is arrested
Contraction is numb, muscles and bones impotence.
Erythrina bark：Pungent, slight bitter is put down.Return liver, the spleen channel.Wind-damp dispelling, degrading the channel.For rheumatic arthritis, soreness of waist and knee joint.
It is preferred that the dry bark of Araliaceae kalopanax septemlobus, mainly contains erythraline, amino acid, organic acid etc., flooding agent is to a variety of skins
Skin fungi has inhibiting effect.Contained alkaloid can benumb and relax striated muscle, and Central nervous system has sedation.
Ministerial drug：First, auxiliary monarch drug in a prescription reinforces the drug of the main disease for the treatment of or main symptom；Make second is that playing treatment for simultaneous disease or accompanying symptoms
Drug.Its efficacy of a drug is less than monarch drug in a prescription.
Ministerial drug aconiti preparata,radix of the present invention, wild aconite root, lycopodium calvatum, lopseed, the root of Chinese clematis, caulis piperis futokadsurae.
Aconiti preparata,radix：It is pungent, bitter, heat；The thoughts of returning home, liver,kidney,spleen warp.Dispelling wind and eliminating dampness, antalgic.For wind-cold-dampness arthralgia, arthritis
Bitterly, trusted subordinate's crymodynia, cold hernia is had a pain and narcotic analgesic.
Wild aconite root；It is pungent, bitter, heat；The thoughts of returning home, liver,kidney,spleen warp.Dispelling wind and eliminating dampness, antalgic.For wind-cold-dampness arthralgia, arthritis
Bitterly, trusted subordinate's crymodynia, cold hernia is had a pain and narcotic analgesic.
Lycopodium calvatum：It is slight bitter, acrid in flavour and warm in nature for the drying herb of lycopod.Return liver, spleen, kidney channel.Dispelling wind and eliminating dampness, relaxing tendons and activating collaterals.With
In joint pain, joint stuffiness.
Lopseed：It is acrid in flavour and warm in nature.Return liver and kidney channel.Dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, eliminating stasis to subdue swelling.For arthralgia pain due to rheumatism, muscles and bones contraction
Contracting, the disturbance of lower legs due to pathogenic cold and dampness, lumbar strain, paralysis, amenorrhoea, eczema of scrotum, sore furuncle poison.
The root of Chinese clematis：It is pungent, salty, temperature.Return bladder warp.Wind-damp dispelling, degrading the channel.For arthralgia pain due to rheumatism, extremity numbness, tendon and vessel is arrested
Contraction, joint stuffiness.
Caulis piperis futokadsurae：It is pungent, bitter, tepor.Return liver warp.Wind-damp dispelling, degrading the channel, stopping numbness pain.For wind-cold-dampness arthralgia, podomere pain,
Muscle arteries and veins contraction, joint stuffiness.
Adjutant：There are three types of meanings, first, supplementary drug, assistance monarch, ministerial drug is to reinforce therapeutic effect, or directly treats secondary disease
Shape；Second is that supplementary inhibitory medicine, to eliminate or slow down the toxicity of monarch, ministerial drug and strong；
Adjutant of the present invention is with pawpaw, cortex acanthopanacis, Rhizoma Chuanxiong, Radix Angelicae Sinensis, safflower, folium artemisiae argyi, turmeric.
Cortex acanthopanacis, pawpaw can restrict the sedation of erythrina bark Central nervous, enhance its wind-damp dispelling, the effect of degrading the channel
Fruit.
Rhizoma Chuanxiong：It is acrid in flavour and warm in nature.Return liver, courage, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For chest impediment and cardialgia, chest side of body shouting pain is fallen
Flutter swelling and pain, irregular menstruation, closed dysmenorrhea, addiction lump in the abdomen abdominal pain, headache, arthralgia pain due to rheumatism.
Radix Angelicae Sinensis, safflower, folium artemisiae argyi, turmeric：All have replenishing and activating blood, temperature sun whole body, the effect to promote blood circulation.
Make medicine：There are two types of meaning, first, guiding drug, can in the side of drawing all medicines with up to disease drug；Second is that harmonizing drug, i.e.,
Drug with coordinating the drug actions of a prescription effect.
Guiding drug of the present invention is using cassia twig, Herba Lycopi, asarum.
Herba Lycopi：It is warm-natured, return liver and kidney channel.Inducing diuresis for removing edema, the effect of diversion downlink.
Cassia twig：Sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi, flat gas that spins.Has the function of coordinating the drug actions of a prescription.
Asarum：It is acrid in flavour and warm in nature.The thoughts of returning home, lung, kidney channel, priming uplink are sensible.With expelling wind and clearing away cold, wind-expelling pain-stopping is sensible, warm lung
Change drink.
Chinese medicine preparation using the present invention is treated, and is best with fumigation and steaming therapy.Fumigation and steaming therapy is to cure China's tradition
The novel method for the treatment of being combined with modern science and technology is learned, herbal fumigation therapy is that herbal fumigation steam medicine-bath (vapour treatment) equipment is used for
Medical institutions suit the medicine to the illness the unique treatments methods such as a variety of diseases of dosing fumigation treatment.Herbal fumigation therapy not only rheumatism, rheumatoid,
Show tcm characteristic and speciality in terms of the treatments of the diseases such as osteoarticular injury, skin especially, and in health cultivation and rehabilitation, improve the body and culature, disappear
Except fatigue, to overcome inferior health etc. be also effective method.
Herb steam therapy is the principle according to diagnosis and treatment based on an overall analysis of the illness and the patient's condition, with fumigation treatment couch (machine), is pierced by constant warm
Swash skin, cause blood vessel dilatation, improves the blood circulation for fumigating position；The a large amount of Chinese medicines contained in Chinese medicine steam simultaneously effectively at
The approach such as point it is directed through whole body skin, hole key, permeates through cave etc., absorbs, spreads and enter space between skin and muscles, internal organs, directly dredges whole body
Space between skin and muscles, warming channel and expelling cold, dispelling wind and eliminating dampness, dredging the channel, it is promoting blood circulation and removing blood stasis, remove obstruction in channels to relieve pain, obtain satisfied therapeutic effect.
The method that Chinese medicine preparation using the present invention carries out fumigation treatment is：Raw material, powder are weighed by prescription weight distribution ratio
It is packed into non-woven bag after broken mixing, one bag of Chinese medicine preparation is put into gassing machine when treatment, after adding water, 20- is fumigated at whole body or position
30 minutes.One bag of Chinese medicine preparation net weight 220-400g, in gassing machine plus 10-14 times is measured water.
The Chinese medicine preparation of the present invention can also use hot application or clean method and use.
Hot application is：It weighs the raw material of the weight distribution ratio, crushes and be packed into non-woven bag after mixing, when treatment takes one bag
The steaming of Chinese medicine preparation heat is wrapped with dry towel after a certain period of time spreads on affected part, removes towel when proper temperature；Every bag of Chinese medicine
Preparation Reusability 10 times need to only steam 20min later for the first time using needing heat to steam 30min；The Chinese medicine preparation is first used before heat is steamed
Vinegar or white wine wetting.The hot compress time is 35-45min.
Scouring method is：It weighs the raw material of the weight distribution ratio, crushes and be packed into non-woven bag after mixing, when treatment takes one bag
Chinese medicine preparation cleans painful area after adding boiling to open with non-metallic vessel.
When using hot application or cleaning method, one bag of preferred 220-300g of Chinese medicine preparation net weight.
Three kinds of application methods, every bag of medicament can use 10 times, and continuous treatment 30 times is as a treatment course.Depending on state of an illness weight,
The general 1-2 course for the treatment of can fully recover.
The beneficial effects of the present invention are：
1, each group patent medicine medicine source is abundant in inventive formulation, and cheap, manufacturing cost is low.Most of indication is suffered from
Person, it is only necessary to which 26 packet medicaments of the course for the treatment of can fully recover, and treatment cost is low.Patient can select fumigation and steaming therapy, heat according to actual conditions
Dressing treatment method cleans therapy, can adapt to the demand of different patients.
2, each group patent medicine has good analgesia and Li Shui effects while treatment of arthritis in inventive formulation,
When using 13 packet medicament of the course for the treatment of, arthritic pain and arthroedema symptom disappear.
3, the present invention is particularly suitable for using herb steam therapy, with fumigation treatment couch (machine), is pierced by constant warm
Swash skin, cause blood vessel dilatation, improves the blood circulation for fumigating position；The a large amount of Chinese medicines contained in Chinese medicine steam simultaneously effectively at
The approach such as point it is directed through whole body skin, hole key, permeates through cave etc., absorbs, spreads and enter space between skin and muscles, internal organs, directly dredges whole body
Space between skin and muscles, warming channel and expelling cold, dispelling wind and eliminating dampness, dredging the channel, it is promoting blood circulation and removing blood stasis, remove obstruction in channels to relieve pain, better therapeutic effect can be obtained.
Specific implementation mode
Be described further below technical scheme of the present invention, but claimed range be not limited to it is described.
Prepare embodiment
Embodiment 1
Pawpaw 25g, lopseed 25g, turmeric 20g, Herba Lycopi 25g, caulis piperis futokadsurae 25g, aconiti preparata,radix 20g, cortex acanthopanacis 20g, Radix Angelicae Sinensis
20g, safflower 20g, folium artemisiae argyi 25g, erythrina bark 25g, wild aconite root 20g, lycopodium calvatum 25g, cassia twig 20g, root of Chinese clematis 25g, rhizoma homalonemae
25g, asarum 15g, Rhizoma Chuanxiong 25g.
When treatment：Raw material is weighed by prescription weight distribution ratio, is packed into non-woven fabrics sack after crushing mixing, when treatment, is used
One bag of Chinese medicine preparation is added in gassing machine, and 10 times of amount water are added, suitable temperature is adjusted to after waiting water to open, carries out whole body or partial fumigating is controlled
It treats 25 minutes.
Embodiment 2
Pawpaw 20g, lopseed 20g, turmeric 15g, Herba Lycopi 20g, caulis piperis futokadsurae 20g, aconiti preparata,radix 15g, cortex acanthopanacis 15g, Radix Angelicae Sinensis
15g, safflower 15g, folium artemisiae argyi 20g, erythrina bark 20g, wild aconite root 15g, lycopodium calvatum 20g, cassia twig 15g, root of Chinese clematis 20g, rhizoma homalonemae
20g, asarum 20g, Rhizoma Chuanxiong 20g.
When treatment：Raw material is weighed by prescription weight distribution ratio, is packed into non-woven fabrics sack after crushing mixing, when treatment, is used
One bag of Chinese medicine preparation is added in gassing machine, and 12 times of amount water are added, suitable temperature is adjusted to after waiting water to open, carries out whole body or partial fumigating is controlled
It treats 35 minutes.
Embodiment 3
Pawpaw 15g, lopseed 15g, turmeric 10g, Herba Lycopi 15g, caulis piperis futokadsurae 15g, aconiti preparata,radix 10g, cortex acanthopanacis 10g, Radix Angelicae Sinensis
10g, safflower 10g, folium artemisiae argyi 15g, erythrina bark 15g, wild aconite root 10g, lycopodium calvatum 15g, cassia twig 10g, root of Chinese clematis 15g, rhizoma homalonemae
15g, asarum 5g, Rhizoma Chuanxiong 15g.
When treatment：Raw material is weighed by prescription weight distribution ratio, is packed into non-woven fabrics sack after crushing mixing, when treatment, is used
One bag of Chinese medicine preparation is added in gassing machine, and 14 times of amount water are added, suitable temperature is adjusted to after waiting water to open, carries out whole body or partial fumigating is controlled
It treats 45 minutes.
Embodiment 4
Pawpaw 25g, lopseed 15g, turmeric 20g, Herba Lycopi 15g, caulis piperis futokadsurae 25g, aconiti preparata,radix 10g, cortex acanthopanacis 20g, Radix Angelicae Sinensis
10g, safflower 20g, folium artemisiae argyi 15g, erythrina bark 25g, wild aconite root 10g, lycopodium calvatum 25g, cassia twig 10g, root of Chinese clematis 25g, rhizoma homalonemae
15g, asarum 15g, Rhizoma Chuanxiong 15g.
It weighs the raw material of above-mentioned weight distribution ratio, crushes and be packed into non-woven bag after mixing, when treatment takes one bag of Chinese medicine preparation
It is infiltrated on 10min in white wine, taking-up drains, and sets on pot after heat steams 30min, is wrapped with dry towel and spread on affected part, wait for proper temperature
When remove towel；Every bag of Chinese medicine preparation Reusability 10 times steams 30min using heat for the first time, and heat steams 20min every time later；
The Chinese medicine preparation first uses vinegar or white wine to soak before heat is steamed, hot compress 45min.
Embodiment 5
Pawpaw 20g, lopseed 20g, turmeric 15g, Herba Lycopi 20g, caulis piperis futokadsurae 20g, aconiti preparata,radix 15g, cortex acanthopanacis 15g, Radix Angelicae Sinensis
15g, safflower 15g, folium artemisiae argyi 20g, erythrina bark 20g, wild aconite root 15g, lycopodium calvatum 20g, cassia twig 15g, root of Chinese clematis 20g, rhizoma homalonemae
20g, asarum 20g, Rhizoma Chuanxiong 20g.
It weighs the raw material of above-mentioned weight distribution ratio, crushes and be packed into non-woven bag after mixing, when treatment takes one bag of Chinese medicine preparation
It is infiltrated on 8min in white wine, taking-up drains, and sets on pot after heat steams 30min, is wrapped with dry towel and spread on affected part, when proper temperature
Remove towel；Every bag of Chinese medicine preparation Reusability 10 times steams 30min using heat for the first time, and heat steams 20min every time later；Institute
State Chinese medicine preparation first uses vinegar or white wine to soak before heat is steamed, hot compress 40min.
Embodiment 6
Pawpaw 15g, lopseed 25g, turmeric 10g, Herba Lycopi 25g, caulis piperis futokadsurae 15g, aconiti preparata,radix 20g, cortex acanthopanacis 10g, Radix Angelicae Sinensis
20g, safflower 10g, folium artemisiae argyi 25g, erythrina bark 15g, wild aconite root 20g, lycopodium calvatum 15g, cassia twig 20g, root of Chinese clematis 15g, rhizoma homalonemae
25g, asarum 5g, Rhizoma Chuanxiong 25g.
It weighs the raw material of above-mentioned weight distribution ratio, crushes and be packed into non-woven bag after mixing, when treatment takes one bag of Chinese medicine preparation
It is infiltrated on 10min in white wine, taking-up drains, and sets on pot after heat steams 30min, is wrapped with dry towel and spread on affected part, wait for proper temperature
When remove towel；Every bag of Chinese medicine preparation Reusability 10 times steams 30min using heat for the first time, and heat steams 20min every time later；
The Chinese medicine preparation first uses vinegar or white wine to soak before heat is steamed, hot compress 35min.
Embodiment 7
Pawpaw 25g, lopseed 25g, turmeric 20g, Herba Lycopi 25g, caulis piperis futokadsurae 25g, aconiti preparata,radix 20g, cortex acanthopanacis 20g, Radix Angelicae Sinensis
20g, safflower 20g, folium artemisiae argyi 25g, erythrina bark 25g, wild aconite root 20g, lycopodium calvatum 25g, cassia twig 20g, root of Chinese clematis 25g, rhizoma homalonemae
25g, asarum 15g, Rhizoma Chuanxiong 25g.
It weighs the raw material of the weight distribution ratio, crushes and be packed into non-woven bag after mixing, when treatment takes one bag of Chinese medicine preparation
Painful area is cleaned after being opened with non-metallic vessel plus boiling.
Embodiment 8
Pawpaw 15g, lopseed 15g, turmeric 10g, Herba Lycopi 15g, caulis piperis futokadsurae 15g, aconiti preparata,radix 10g, cortex acanthopanacis 10g, Radix Angelicae Sinensis
10g, safflower 10g, folium artemisiae argyi 15g, erythrina bark 15g, wild aconite root 10g, lycopodium calvatum 15g, cassia twig 10g, root of Chinese clematis 15g, rhizoma homalonemae
15g, asarum 5g, Rhizoma Chuanxiong 15g.
It weighs the raw material of the weight distribution ratio, crushes and be packed into non-woven bag after mixing, when treatment takes one bag of Chinese medicine preparation
Painful area is cleaned after being opened with non-metallic vessel plus boiling.
Comparative example 1
Monarch drug in a prescription is only used in formula, be not added with ministerial drug, adjutant and makes medicine, and other treatment method is the same as embodiment 1.
Comparative example 2
Monarch drug in a prescription and ministerial drug are only used in formula, be not added with adjutant and makes medicine, and other treatment method is the same as embodiment 4.
Comparative example 3
Monarch drug in a prescription, ministerial drug and adjutant are only used in formula, being not added with makes medicine, and other treatment method is the same as embodiment 7.
Comparative example 4
Chinese patent CN201410084969.1 treats patient by the prescription and preparation method of embodiment 1.
Pharmacological Examples
Test example 1
With reference to specific embodiment, present invention is further described in detail, but not as a limitation of the invention.
The influence of writhing response caused by influence and Dichlorodiphenyl Acetate to the effect of mouse hot-plate induced pain
Experimental drug：
Blank control group：Physiological saline group
Control group 1-4：The preparation therapy of comparative example 1-4 is corresponded to respectively.
Test group 1-8：The preparation therapy of corresponding embodiment 1-8 respectively.
Experimental animal：Healthy Kunming mouse 390,20~24g of weight.
Experimental method：Female mice is taken, random point of 13 groups, i.e. blank control group, control group 1-4,1- of the embodiment of the present invention
8, the daily vola of administration group is administered three times, and dosage is 4.5g crude drugs/kg, and physiological saline group, which is given, waits capacity physiological saline,
Successive administration 3 days, after the last administration 1h each mouse is individually fixed in 55 ± 0.5 DEG C of hot-plate instrument, using lick metapedes as " pain
Indicator reaction bitterly ", mouse the results are shown in Table 1 to the reaction time of hot plate pain after observation administration.
1 analgesic test result of table
| Group | The hot plate pain reaction time/s | Writhing number/10min |
| Blank control group | 10.4±1.9 | 32.4±0.9 |
| Control group 1 | 13.7±2.5 | 28.9±1.4 |
| Control group 2 | 17.9±1.9* | 24.3±1.5* |
| Control group 3 | 20.6±1.7** | 19.6±2.8** |
| Control group 4 | 11.5±2.1 | 29.6±3.2 |
| Test group 1 | 24.0±0.4** | 13.7±0.2** |
| Test group 2 | 23.3±0.7** | 15.3±0.3** |
| Test group 3 | 25.7±1.2** | 14.7±0.9** |
| Test group 4 | 22.3±0.4** | 16.7±1.0** |
| Test group 5 | 21.7±1.7** | 17.4±0.6** |
| Test group 6 | 23.0±2.1** | 15.7±1.2** |
| Test group 7 | 23.4±1.3** | 17.6±1.1** |
| Test group 8 | 23.7±0.8** | 18.3±0.7** |
As shown in Table 1, the preparation for treating small white mouse hot plate pain reaction time of test group 1-8 and writhing number are compared with blank control
Group highly significant (P ＜ 0.01), there was no significant difference compared with blank control group for control group 1 and control group 4；Control group 2 compares blank
Control group significant difference (P ＜ 0.05), the relatively control blank control group difference highly significant (P ＜ 0.01) of control group 3, illustrates this hair
Ming monarch minister, helps, medicine is made to be component and the collocation by science, and monarch minister, helps, keeps medicine indispensable, and comparative example 3 of the invention lacks
It is weary to make medicine, that is, lack cassia twig, Herba Lycopi, asarum, compares comparative example 1-3 and test example 7 it is found that ministerial drug, adjutant and making medicine and we
Other formulas have mutually synergistic effect, can enhance drug effect, as known from Table 1, make medicine i.e. cassia twig, Herba Lycopi, asarum not only in we
Have the function of tying-in and reconciliation, also there is enhancing composition analgesic effect.After from table 1 and test situation it is found that in
The analgesic activity of state patent CN201410084969.1 is not strong.
Test example 2
Influence to small white mouse formaldehyde foot swelling
Experimental drug and grouping are the same as test example 1.
Experimental method：
Healthy male white mouse 195 is taken, 13 groups is randomly divided into, every group 15, injects 2% formaldehyde 0.1ml before experiment
It is caused under the right metapedes plantar aponeurosis of big white mouse scorching.Not cause scorching left foot as a contrast, using the difference of the two vola pedis perimeter as swelling journey
Spend index.Scorching vola pedis is caused to be coated with drug, dosage is：0.02g/ only, is measured for 8,16,24,48,72 hours after causing inflammation
1 time.1 medicine is applied again after often surveying 1 time, is applied 5 times altogether, be the results are shown in Table 2.
Influence of the table 2 to small white mouse formaldehyde foot swelling
As shown in Table 2, test group 1-8 just plays the role of significantly inhibiting small white mouse foot swelling for 16 hours, after 24 hours
Play the role of that small white mouse is inhibited to cause scorching foot swelling, compared with 1 difference highly significant of control group (P ＜ 0.01)；It is aobvious compared with control group 2,4 differences
It writes (P ＜ 0.05), control group 3 illustrates monarch of the present invention, minister, helps, makes medicine compared with blank control group difference highly significant (P ＜ 0.01)
It is the component by science and collocation, monarch minister, helps, keeps medicine indispensable, and minister, helps, makes medicine to a certain extent and have collaboration monarch
Medicine acts on, and can enhance the effect that monarch drug in a prescription eliminates swelling, especially make the addition of medicine, and our inducing diuresis for removing edema, diversion downlink is promoted to make
With more obviously.
Experiment conclusion：Above-mentioned experiment shows that pharmaceutical composition collocation of the invention is reasonable, not only with treatment of arthritis
Effect, and the analgesia of the present invention and the effect of inducing diuresis for removing edema are it is also obvious that our monarch drug in a prescription treatment of arthritis, Huan Zheyi can be cooperateed with
It is more preferable from property.
Toxicity embodiment
(1) acute toxicity test
Preparation made from the test example 1-8 therapeutic combinations of the present invention is used to stifling, hot compress and tea to kunming mice to wash,
Do not occur any toxic reaction, without animal dead in one week.
(2) long term toxicity test
The treatment preparation of test example 1-8 of the present invention is subjected to long term toxicity test, continuous large dosage (adult human dose to rat
10 times of concentration) administration, administration time grows (90 days), with the front and back general performance of animal administration, weight, food ration, hematology
And the classification of Biochemical Indices In Serum, routine urinalysis, marrow, organ weights, organ coefficient be Testing index, and be aided with animal respectively organize it is dirty
The pathological examination of device, the toxicity profile of overall merit drug.As a result show that the indices of rat are normal.Histopathology
Inspection result shows, rat skin tissue and each tissue internal organs no abnormality seen.
In summary：The present invention treatment of arthritis Chinese medicine composition toxicity under this prescription dosage using be peace
Complete.
Clinical example
Test group：Rheumatic arthritis is treated using test example 1, the prescription of test example 4 and test example 7 and therapeutic modality；
Control group is treated：It takes and chases after wind collaterals activating pills, 3 times a day, 3 tablets once；Diclofenac sodium enteric tablet, every 25 milli
Gram, 2 tablets once, 2 times a day.
Control group and test group treat 2 courses for the treatment of.
Treatment results：Rheumathritis patient 250 is treated by this law, after 1 course for the treatment of of taking medicine, diagnoses the pass of patient
Section is bent and stretched, and subcutaneous nodule symptom is eased；Painful swelling of joints, soreness of waist and knee joint situation disappear；In 75 through clinical treatment, cure
68, pain symptom all disappears；Some patients are not recurred so far；Effective person 6；What sb.'s illness took a favorable turn has 1, and total cure rate reaches
90.7%；From table 3 it is observed that the effect of test example 1 (fumigation and steaming therapy) of the present invention, is better than test example 4 (hot application) and examination
Test example 7 (liquid puts the method for washing on the skin), it may be possible to because of fumigation treatment couch (machine), skin be stimulated by constant warm, blood vessel is caused to expand
, improve the blood circulation for fumigating position；The a large amount of effective component of chinese medicine contained in Chinese medicine steam simultaneously are directed through whole body flesh
Skin, hole key the approach such as permeate through cave etc., absorb, spread and enter space between skin and muscles, internal organs, directly dredge whole body space between skin and muscles, warming channel and expelling cold, dispel
Wind dehumidifying, dredging the channel, it is promoting blood circulation and removing blood stasis, remove obstruction in channels to relieve pain, better therapeutic effect can be obtained.
3 clinical treatment situation of table
The above, embodiment are only to the preferred embodiment of the present invention, and the present invention can not still be disobeyed with others
The concrete form of the spirit or essential characteristics of the present invention is carried on the back to summarize.Therefore, in all respects, the above-mentioned reality of the present invention
The description of the invention can only be considered and cannot limit invention by applying scheme all, and claims indicate the scope of the present invention,
And above-mentioned explanation does not point out the scope of the present invention, therefore, with the comparable meaning and scope of claims of the present invention
Interior any variation is all considered as being included within the scope of the claims.
Claims (10)
1. a kind of Chinese medicine composition and preparation for treatment of arthritis, it is characterised in that：Include the original of following weight
Material：15-25 parts of pawpaw, 15-25 parts of lopseed, 10-20 parts of turmeric, 15-25 parts of Herba Lycopi, 15-25 parts of caulis piperis futokadsurae, aconiti preparata,radix 10-
20 parts, 10-20 parts of cortex acanthopanacis, 10-20 parts of Radix Angelicae Sinensis, 10-20 parts of safflower, 15-25 parts of folium artemisiae argyi, 15-25 parts of erythrina bark, wild aconite root
10-20 parts, 15-25 parts of lycopodium calvatum, 10-20 parts of cassia twig, 15-25 parts of the root of Chinese clematis, 15-25 parts of rhizoma homalonemae, 5-15 parts of asarum, Rhizoma Chuanxiong
15-25 parts.
2. being used for the Chinese medicine composition and preparation for the treatment of of arthritis as described in claim 1, it is characterised in that：Including weighing as follows
Measure the raw material of part proportioning：20 parts of pawpaw, 20 parts of lopseed, 15 parts of turmeric, 20 parts of Herba Lycopi, 20 parts of caulis piperis futokadsurae, 15 parts of aconiti preparata,radix, five
Add 15 parts of skin, 15 parts of Radix Angelicae Sinensis, 15 parts of safflower, 20 parts of folium artemisiae argyi, 20 parts of erythrina bark, 15 parts of wild aconite root, 20 parts of lycopodium calvatum, cassia twig 15
Part, 20 parts of the root of Chinese clematis, 20 parts of rhizoma homalonemae, 10 parts of asarum, 20 parts of Rhizoma Chuanxiong.
3. being used for the Chinese medicine composition and preparation for the treatment of of arthritis as claimed in claim 1 or 2, it is characterised in that：Weigh weight
The raw material of part proportioning is measured, non-woven bag is packed into after crushing mixing, one bag of Chinese medicine preparation is put into gassing machine when treatment, after adding water,
Whole body or position are 20-30 minutes stifling.
4. being used for the Chinese medicine composition and preparation for the treatment of of arthritis as claimed in claim 3, it is characterised in that：In described one bag
Medicine preparation net weight 220-400g, in gassing machine plus 10-14 times is measured water.
5. being used for the Chinese medicine composition and preparation for the treatment of of arthritis as claimed in claim 1 or 2, it is characterised in that：Can also it make
With hot application or clean method treatment of arthritis.
6. being used for the Chinese medicine composition and preparation for the treatment of of arthritis as claimed in claim 5, it is characterised in that：The hot compress
Method is：It weighs the raw material of the weight distribution ratio, crushes and be packed into non-woven bag after mixing, when treatment takes one bag of Chinese medicine preparation heat to steam
It is wrapped after a certain period of time with dry towel and spreads on affected part, remove towel when proper temperature.
7. being used for the Chinese medicine composition and preparation for the treatment of of arthritis as claimed in claim 6, it is characterised in that：The hot application
Every bag of Chinese medicine preparation Reusability 10 times need to only steam 20min later for the first time using needing heat to steam 30min；The hot compress time is 35-
45min。
8. being used for the Chinese medicine composition and preparation for the treatment of of arthritis as claimed in claim 7, it is characterised in that：The hot compressed drug
Material first uses vinegar or soaking in Chinese liquor 3-5min before heat is steamed.
9. being used for the Chinese medicine composition and preparation for the treatment of of arthritis as claimed in claim 5, it is characterised in that：The scouring
Method is：It weighs the raw material of the weight distribution ratio, crushes and be packed into non-woven bag after mixing, when treatment takes one bag of Chinese medicine preparation with non-
Metalware cleans painful area after adding boiling to open.
10. the Chinese medicine composition and preparation for the treatment of of arthritis as claimed in claim 1 or 2 disappear in preparation analgesia and/or Li Shui
Application in swollen drug.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109331151A (en) * | 2018-12-10 | 2019-02-15 | 周育霖 | A kind of rheumatism bath medicine and preparation method thereof |
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|---|---|---|---|---|
| CN104435999A (en) * | 2013-09-14 | 2015-03-25 | 牛振侠 | Preparation method of traditional Chinese medicine for arthritis |
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2018
- 2018-06-26 CN CN201810667123.9A patent/CN108671195A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435999A (en) * | 2013-09-14 | 2015-03-25 | 牛振侠 | Preparation method of traditional Chinese medicine for arthritis |
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| 于亭等: "玻璃酸钠配合中药内服外洗治疗膝关节骨性关节炎临床观察", 《吉林中医药》 * |
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Application publication date: 20181019 |