CN106215046A - A kind of Chinese medicine treating acute gouty arthritis - Google Patents
A kind of Chinese medicine treating acute gouty arthritis Download PDFInfo
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- CN106215046A CN106215046A CN201610653989.5A CN201610653989A CN106215046A CN 106215046 A CN106215046 A CN 106215046A CN 201610653989 A CN201610653989 A CN 201610653989A CN 106215046 A CN106215046 A CN 106215046A
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Abstract
The present invention relates to medicine, a kind of Chinese medicine treating acute gouty arthritis.Specific aim specific short, side effect is there is no greatly, the problem that effect is undesirable for western modern medicine.The present invention provides a kind of Chinese medicine treating acute gouty arthritis, by weight meter: Rhizoma Atractylodis 10 20g, Cortex Phellodendri 5 15g, Radix Cyathulae 20 40g, Semen Coicis 20 40g, Cortex Moutan 5 15g, Radix Paeoniae Rubra 10 20g, Bi 20 40g, Rhizoma Smilacis Glabrae 20 40g, Radix Clematidis 15 25g, Rhizoma Cyperi (processed) 10 20g, Rhizoma Dioscoreae Nipponicae 20 40g, Fructus Chaenomelis 15 25g, Fructus Crataegi 10 20g, Flos Carthami 10 20g, eupolyphaga 10 20g, Pheretima 10 20g, Rhizoma Corydalis 20 30g, Radix Glycyrrhizae 5 10g make.The present invention has clots absorbing eliminating stagnation, effect of tonneau water channel, meets theory of Chinese medical science and hits again the pathogenic characteristic of gouty arthritis, and determined curative effect, safety is high.
Description
Technical field
The present invention relates to medicine, a kind of Chinese medicine treating acute gouty arthritis.
Background technology
Along with China's expanding economy, the change of dietary structure, frumentum constitutes the meat composition ratio than minimizing and increases, and always
The arrival of ageization society, the sickness rate of gouty arthritis raises the most year by year, and age of onset youth is melted into the morbidity of this disease and becomes
Gesture, has a strong impact on quality of life and the work of patient, will become the another big killer that harm compatriots are healthy, the most more come
More come into one's own.
Gout (gout) is due to purine metabolic disturbance, uric acid excretion disorder, causes human body serum uric acid level extremely to increase,
A kind of different substantiality disease that urate crystal deposits between tissue and formed.With hyperuricemia, tophaceous deposition, characteristic
Acute and chronic arthritic recurrent exerbation, even renal failure are clinical characters, have a strong impact on patients ' life quality.Gout is
Common onset symptoms, the type being also most basic is acute gouty arthritis, preferably occurs in joint, Lower Distal Extremities one side,
Starting account for the more than half of sickness rate in Metatarsophalangeal joint；Typical onset is typically many woke up with a start because of toes pain at midnight,
Sometimes showing effect in burst, onset is hurried, lancinates, stings that to bite sample pain be its classical symptom, and with joint and surrounding tissue
Red, swollen, hot, bitterly.Along with course advancement, gradually invade and ankle, knee joint, wrist, each joint such as refer to.This disease male's frequently-occurring disease is in middle age, female
Property frequently-occurring disease after menopause, and male is higher than women, with estrogen, this may can promote that uric acid metabolism is relevant.Root it was found that
Uric acid has certain impact to blood vessel and metabolism, and therefore hyperuricemia also can cause coronary heart disease, hypertension and cerebrovas-cularaccident.With
The reach of science, especially immunology and the development of molecular biology, inflammatory cell, cytokine and inflammatory body are gradually by people
Recognize, research shows, they for generation, the development of gouty arthritis until natural remission has highly important meaning
Justice.
In Chinese medicine, there is no " gouty arthritis " this definite name of disease, but in Traditional Chinese Medicine books visible a lot
For the description of this disease similar symptoms, and to this disease etiology and pathogenesis and the record of diagnosis and treatment experience: " Plain Questions numbness opinion ": " wind
Cold-damp three gas is miscellaneous extremely, combined into numbness, its migratory BI-syndrome caused mainly by pathogenic wind, BI-syndrome caused mainly by pathogenic cold being called painful BI, dampness victor be damp arthralgia also." Zhang Zhong
Scape " Medical Treasures of the Golden Chamber apoplexy severe and migratory arthralgia ": " suffering from arthritis, unable to flex and stretch the extremities, pain, Aconiti Decoction master it "." lattice cause remaining unit's ZHU Dan-xi
Opinion gout opinion ": " those gout persons, big rate is heated self-boiling because of blood, and thereafter or relate to cold water, or vertical wetland or pectinid take cool, or
Crouching and work as wind, cold and cool outer spiral, warm blood must be trembled with fear, strongly fragrant turbid solidifying puckery, so having a pain." " gout 13 in red small stream hand mirror volume ": " blood is long
Hot, sense is cold to be emitted and wet must not run, so having a pain, night then pain the most very, row in the moon also, also has hematasthenic phlegm to have a pain up and down by meridians.”
Bright Zhang Jingyue is stated in " Jing Yue's complete work tinea pedis ": " being outward that YIN-cold water is wet, modern damp attacks people's flesh tendon, interior by delicious food usually
Excessively, the damp and hot part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, cold tie strongly fragrant and heat-transformation, stop skin mutually with damp ... diseased region redness hectic fever, the most then osteomyelitis ".
The traditional Chinese medical science is thought, natural endowment is not enough, adds the happiness feed day after tomorrow greasy and surfeit flavour, the with the passing of time impairment of the spleen, or old rear spleen kidney
Functional disorder is the main cause of gouty arthritis morbidity, also has certain relation with the inducement such as overstrain, diet, environment, diseases caused by exogenous pathogenic factor.
The purpose that gouty arthritis is treated by modern medicine is: gouty arthritis acute attack stage to be controlled rapidly
System；Reduce acute arthritis recurrence；Reduce serum uric acid level, prevent urate deposition prevention destruction of joint and kidney damage；Sternly
Severe one needs to use operation method to remove tophus, or the joint damaged by orthopaedic treatment, to improve the quality of living.To this
Sick treatment, doctor trained in Western medicine many employings colchicine, uric acid resisting medicine, NSAID (non-steroidal anti-inflammatory drug), or by sides such as joint cavity injection medicines
Formula.Although there being certain curative effect, but side effect is big, and effect is effective not as Chinese medicine.Chinese medicine then can overall be held concurrently
Turn round and look at, treating both the principal and secondary aspects of a disease, can not only mitigation symptoms, and can reach whole body conditioning purpose.
Summary of the invention
For above-mentioned situation, for solving the defect of prior art, the purpose of the present invention is just to provide one and treats acute pain
The arthritic Chinese medicine of wind, can effectively solve at present because western modern medicine there is no specific aim specific short, side effect greatly, and effect is undesirable
Problem.
The present invention solves the technical scheme of problem:
A kind of Chinese medicine treating acute gouty arthritis, this Chinese medicine is by weight meter: Rhizoma Atractylodis 10-20g, Cortex Phellodendri 5-15g,
Radix Cyathulae 20-40g, Semen Coicis 20-40g, Cortex Moutan 5-15g, Radix Paeoniae Rubra 10-20g, Bi 20-40g, Rhizoma Smilacis Glabrae 20-40g, Radix Clematidis
15-25g, Rhizoma Cyperi (processed) 10-20g, Rhizoma Dioscoreae Nipponicae 20-40g, Fructus Chaenomelis 15-25g, Fructus Crataegi 10-20g, Flos Carthami 10-20g, eupolyphaga 10-
20g, Pheretima 10-20g, Rhizoma Corydalis 20-30g, Radix Glycyrrhizae 5-10g make.
The pure traditional Chinese medicine of the present invention, has clots absorbing eliminating stagnation, effect of tonneau water channel, meets theory of Chinese medical science and hits again gouty
Arthritic pathogenic characteristic, medicine source is extensive, cheap, determined curative effect, and safety is high, can entirety take into account, treating both the principal and secondary aspects of a disease, not only
Energy mitigation symptoms, and the purpose of whole body conditioning can be reached, there is the biggest advantage.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1
A kind of Chinese medicine treating acute gouty arthritis, this Chinese medicine is by weight meter: Rhizoma Atractylodis 15g, Cortex Phellodendri 10g, river cattle
Knee joint 30g, Semen Coicis 30g, Cortex Moutan 10g, Radix Paeoniae Rubra 15g, Bi 30g, Rhizoma Smilacis Glabrae 30g, Radix Clematidis 18g, Rhizoma Cyperi (processed) 15g, Rhizoma Dioscoreae Nipponicae
30g, Fructus Chaenomelis 18g, Fructus Crataegi 15g, Flos Carthami 15g, eupolyphaga 15g, Pheretima 15g, Rhizoma Corydalis 30g, Radix Glycyrrhizae 6g make.
Embodiment 2
A kind of Chinese medicine treating acute gouty arthritis, this Chinese medicine is by weight meter: Rhizoma Atractylodis 10g, Cortex Phellodendri 15g, river cattle
Knee joint 40g, Semen Coicis 40g, Cortex Moutan 15g, Radix Paeoniae Rubra 20g, Bi 40g, Rhizoma Smilacis Glabrae 20g, Radix Clematidis 25g, Rhizoma Cyperi (processed) 10g, Rhizoma Dioscoreae Nipponicae
20g, Fructus Chaenomelis 25g, Fructus Crataegi 20g, Flos Carthami 10g, eupolyphaga 20g, Pheretima 10g, Rhizoma Corydalis 30g, Radix Glycyrrhizae 10g make.
Embodiment 3
A kind of Chinese medicine treating acute gouty arthritis, this Chinese medicine is by weight meter: Rhizoma Atractylodis 20g, Cortex Phellodendri 5g, Radix Cyathulae
20g, Semen Coicis 20g, Cortex Moutan 5g, Radix Paeoniae Rubra 10g, Bi 20g, Rhizoma Smilacis Glabrae 40g, Radix Clematidis 15g, Rhizoma Cyperi (processed) 20g, Rhizoma Dioscoreae Nipponicae 40g,
Fructus Chaenomelis 15g, Fructus Crataegi 10g, Flos Carthami 20g, eupolyphaga 10g, Pheretima 20g, Rhizoma Corydalis 20g, Radix Glycyrrhizae 5g make.
Theory of Chinese medical science thinks asthenia of both the spleen and kidney, insufficiency of vital energy and blood, and eating and drinking without temperance causes disease transporting and transforming function of the spleen and stomach mistake department in addition, and removing dampness is raw
Expectorant, phlegm accumulating with stagnant blood and send out interior life damp and hot, damp and hot heresy pent-up, hinder QI-blood circulation, fate is defeated, and blood vessels are obstructed, QI-blood circulation
Smooth, stagnation of QI and blood may bring about pain, stasis blocking passages through which vital energy circulates, endogenous damp formation heat-transformation and produce pyretic toxicity, the whole turbid phase of pyrogenicity is endured, phlegm accumulating with stagnant blood, and exopathogen is detained
Muscle, joint, muscle arteries and veins, cause passages through which vital energy circulates impatency, poison tackling key problem to save thus gout occurs.Present invention Rhizoma Atractylodis are drying damp and strengthening spleen, dispel the wind scattered
Cold；Semen Coicis, eliminating dampness by diuresis spleen invigorating, inducing diuresis to remove edema, Cortex Phellodendri heat clearing and damp drying of arranging in pairs or groups, pathogenic fire purging is except steaming；Strengthening spleen, tonifying kidney to effect a permanent cure, Bi, profit
Wet go turbid, wind expelling stagnation removing；Rhizoma Smilacis Glabrae, removing toxic substances, dehumidifying, easing joint movement；Radix Clematidis, wind-damp dispelling, removing obstruction in the collateral to relieve pain；Rhizoma Dioscoreae Nipponicae, dispels the wind
Wet, promoting blood circulation to remove obstruction in the collateral；Fructus Chaenomelis, relaxing muscles and tendons and activating QI and blood in the collateral, stomach function regulating removing dampness；Radix Cyathulae, expelling wind and removing dampness, restore menstrual flow and invigorate blood circulation；Pheretima, heat clearing away is calmed the frightened, is led to
The turbid releasing uric acid of network diuresis, Cortex Moutan, clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling；Radix Paeoniae Rubra, clearing away heat and cooling blood, eliminating stasis to stop pain；Flos Carthami, promoting blood circulation to restore menstrual flow, dispels
Stasis of blood pain relieving；Eupolyphaga, removing blood stasis, reunion of fractured tendons and bones；Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, promoting blood circulation, removing blood stasis and relieving pain class medicine, reuse system perfume
Attached, dispersing the stagnated live-QI to relieve the stagnation of QI, menstruction regulating and pain relieving；Rhizoma Corydalis blood-activating and qi-promoting pain relieving, Fructus Crataegi, circulation of qi promoting dissipating blood stasis；Impose clearing away heat-damp and promoting diuresis, dampness removing heresy turbid
Method, and double blood circulation promoting and blood stasis dispelling, add and use diuresis Chinese medicine, and diuresis can dehumidify gas, with dampness removing spleen invigorating, clearing away heat and promoting diuresis method, gives the kidney invigorating and is good for
Spleen, blood stasis dispelling are let out turbid, reduce hematuria spleen kidney by the method for the kidney invigorating dampness removing, and reducing phlegm, it is turbid to take stopgap measures to let out, and coordinate spleen invigorating to help transporting；Spleen invigorating is mended
Kidney, to effect a permanent cure, coordinates and lets out turbid releasing uric acid, and both coordinate with the purpose reaching treating both the principal and secondary aspects of a disease.
In said components, wherein:
Rhizoma Atractylodis, pungent, bitter, temperature；Drying damp and strengthening spleen, expelling wind and cold；Shennong's Herbal: " main anemofrigid-damp arthralgia, dead flesh convulsion subcutaneous ulcer.Make
Pan-fried bait takes for a long time, and making light of one's life by commiting suicide, it is the most hungry to prolong life.”
Cortex Phellodendri, bitter, cold；Heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment；" Changsha medicine solution ": " Cortex Phellodendri, lets out the damp and hot of own soil,
Second wood is hot and suffocating clearly, adjusts diarrhea of heat type with tenesmus, manages jaundice, abdominal distention, typhoid fever.”
Radix Cyathulae, sweet, micro-hardship；Expelling wind and removing dampness, restores menstrual flow and invigorates blood circulation；" Traditional Chinese Medicine in Sichuan will ": " expelling wind and removing dampness, stimulate the menstrual flow scattered blood.Control cold
Wet waist-leg osteodynia, flaccidity of the lower limbs clonic spasm of the muscle, women's amenorrhea and lump in the abdomen, gonorrhea, hematuria, impotence, mistake are drowned.”
Semen Coicis, sweet, light, cool；Inducing diuresis to remove edema, eliminating dampness by diuresis spleen invigorating, eliminating impediment, clearing away heat and discharging pus；Shennong's Herbal: " main muscular contracture
Contracture, unable to flex and stretch the extremities, rheumatism numbness, the therapeutic method to keep the adverse QI flowing downwards.”
Cortex Moutan, bitter, sweet, it is slightly cold；Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling；Shennong's Herbal: " main cold and heat, apoplexy, convulsion, frightened
Epilepsy pathogen, except hard blood stasis stays house the intestines and stomach.”
Radix Paeoniae Rubra, bitter, it is slightly cold；Clearing away heat and cooling blood, eliminating stasis to stop pain；The Radix Paeoniae Alba, bitter, sour, it is slightly cold；Nourish blood yin fluid astringing, easing the affected liver to relieve pain；" this
Grass is looked for the truth ": " can rush down wood in vain in soil, red then can live in blood stagnant.”
Bi, bitter, flat；Dampness removing goes turbid, wind expelling stagnation removing；Shennong's Herbal: " main lumbago and backache, bone strengthening saves, wind and cold wetted perimeter
Numbness.”
Rhizoma Smilacis Glabrae is sweet, light, flat；Removing toxic substances, dehumidifying, easing joint movement；Compendium of Material Medica: " strengthening the spleen and stomach, bone and muscle strengthening, curing rheumatism,
Profit joint, stopping leak rushes down, and controls contracture osteodynia.”
Radix Clematidis, pungent, salty, temperature；Wind-damp dispelling, removing obstruction in the collateral to relieve pain；" medicineization justice ": " Radix Clematidis, it is suddenly anxious, is apt to walk and do not keep, a surname
Logical twelve channels and collaterals.Cure mainly wind, wet, expectorant is stopped up in stagnant meridians, causes into gout migratory arthralgia caused by wind, arthralgia, or swollen or numb.”
Rhizoma Cyperi (processed), pungent, micro-hardship, micro-sweet, flat；Dispersing the stagnated live-QI to relieve the stagnation of QI, menstruction regulating and pain relieving, regulate the flow of vital energy in tune；Compendium of Material Medica: " profit three is burnt,
Solve six kinds of stagnation-syndromes, only trusted subordinate, limbs, the head, all pains of tooth ear.”
Rhizoma Dioscoreae Nipponicae, bitter, be slightly cold；Wind-damp dispelling, promoting blood circulation to remove obstruction in the collateral；" Shaanxi Chinese herbal medicine ": " control cough, rheumatic arthritis,
Joint disease arthralgia, traumatic injury.
Fructus Chaenomelis, sour, warm；Relaxing muscles and tendons and activating QI and blood in the collateral, stomach function regulating removing dampness；" Bencao Jingshu ": " Fructus Chaenomelis Wen Nengtong muscle stagnant, acid can be held back and be moistened
Full is wet, then tinea pedis arthralgia chiefly caused by damp pathogen is from except also.”
Fructus Crataegi, acid, sweet, tepor；Promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis；Compendium of Material Medica: " dissipating fluid-retention is eaten, phlegm retention feeling of fullness acid regurgitation,
Stagnant blood distending pain.”
Flos Carthami, pungent, warm；Promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing；" book on Chinese herbal medicine converges and says ": " Flos Carthami, removing blood stasis, promoting the circulation of blood and blood, the medicine of tune blood
Also.”
Eupolyphaga, salty, cold, slightly poisonous；Removing blood stasis, reunion of fractured tendons and bones；" Bencao Jingshu ": " controlling traumatic injury and flutter damage, reuniting the fractured tendons and bones is odd
Effect, be JUE YIN meridian medicine also.”
Pheretima, salty, cold；Heat clearing away arresting convulsion, dredging collateral, relieving asthma, diuresis；Compendium of Material Medica: " cold in nature and descending, event cold in nature can solve
All hot diseases, descending thus can diuresis, control foot disease and the meridian dredging also.”
Rhizoma Corydalis, has another name called Rhizoma Corydalis, acrid, bitter, warm；Invigorate blood circulation, circulation of qi promoting, pain relieving；Compendium of Material Medica: " Rhizoma Corydalis, gas in energy promoting the circulation of blood
Stagnant, therefore specially control upper and lower all pains all over the body, among use, simply fantastic.”
Radix Glycyrrhizae is sweet, flat；Relieving spasm to stop pain, clearing away heat to alleviate pain, coordinating the actions of various ingredients in a prescription；Life cold nature, can heat-clearing and toxic substances removing." book on Chinese herbal medicine converges
Speech ": " with middle QI invigorating, the medicine of qi-restoratives removing toxic substances is also.”
The change of inflammatory parameters IL-1 β, IL-8, TNF-α and meaning thereof
Interleukin type cytokines, TNF-α etc. are current gout class medicine targets of Main Function in terms of arthritis
Point.
Modern study confirms: acute gouty arthritis is mainly crystallized the acute inflammatory reaction caused, uric acid by Monosodium urate
Sodium crystallization deposition, at periarticular, stimulates local to produce the inflammatory cytokines such as a large amount of IL-1 β, IL-8, TNF-α, thus causes
Local vasodilation, vascular permeability increase, edema, ooze out, leukocyte recruitment.
Research shows, IL-1 β, TNF-α, as the one-level cytokine in proinflammatory network chain, can not only accelerate inflammation and enter
Exhibition, discharges anti-inflammatory agent such as prostaglandin, leukotriene and oxygen-derived free radicals etc., and can promote collagenase and other neutral proteins
The generation of enzyme, causes the serious consequences such as cartilage matrix disintegrate, cartridge adsorption and osteoclasia, sends out for acute gouty arthritis
Raw, evolution plays an important role.IL-8 is by IL-1 β, two grades of Pro-inflammatory mediator of TNF-α induction, can be in chemotactic
Property granulocyte, wait until addicted to acid (alkali) property granulocyte, lymphocyte inflammation local, to cause inflammation or allergy.Based on IL-1 β,
The important function played in the morbidity of gouty arthritis such as IL-8, TNF-α, during treatment gouty arthritis, can
By suppressing these pro-inflammatory cytokines to produce, to block or to suppress the inflammatory process being mediated by pro-inflammatory cytokine and being excited, to alleviation
The state of an illness has positive effect.
The animal model experiment checking to drug effect of the present invention
1 research contents
Sodium urate crystals (monosodium urate, MSU) induction is used to set up rat acute gouty arthritis model,
During using Drug therapy of the present invention, observe IL-1 β, IL-8 and the changes of contents of TNF-α in synovium of joint, inquire into it
Preventive and therapeutic effect to gouty arthritis, and study its possible mechanism of action, provide theory to depend on for its application clinically
According to.
2 goals in research
By to IL-1 β, IL-8 and TNF-α in invention medicine treatment acute gouty arthritis in rats synovium of joint
Changes of contents, understands its impact on acute gouty arthritis animal model cytokine, and providing for clinical treatment primary disease can
Row foundation.
3 experiment materials
3.1 laboratory animal
The healthy male SD rat 48 of selection, specific pathogen free animal (Specific Pathogen Free, SPF),
Experiment original body mass 200 ± 10g, is provided by Medical School of Zhengzhou University animal experimental center.Animal is used uniformly across independent ventilation cage
Box (individual venti lation cages, IVC) system is fed, point 16 cages, 3, every cage, within every 3 days, changes bedding and padding one
Secondary, drinking-water feed is free schema, and feedstuff is that SPF level grows feedstuff, IVC system control office temperature 23 ± 2 DEG C, humidity 17-
20%, pressure reduction 18kPa, 25 times/h of rate of ventilation, air intake wind speed 31m3/h.Experimental feed 7 days, every day observed and recorded rat body
Weight and change of spirit.
3.2 Experimental agents
A kind of Chinese medicine treating acute gouty arthritis, this Chinese medicine is by weight meter: Rhizoma Atractylodis 15g, Cortex Phellodendri 10g, river cattle
Knee joint 30g, Semen Coicis 30g, Cortex Moutan 10g, Radix Paeoniae Rubra 15g, Bi 30g, Rhizoma Smilacis Glabrae 30g, Radix Clematidis 18g, Rhizoma Cyperi (processed) 15g, Rhizoma Dioscoreae Nipponicae
30g, Fructus Chaenomelis 18g, Fructus Crataegi 15g, Flos Carthami 15g, eupolyphaga 15g, Pheretima 15g, Rhizoma Corydalis 30g, Radix Glycyrrhizae 6g make.
3.3 experiment reagents: rat IL-1 β, IL-8, TNF-α Quantikine ELISA kits, sodium urate crystals, colchicine
Sheet.
3.4 experimental apparatus: low-temperature and high-speed centrifuge, tissue homogenate instrument, constant water bath box, magnetic stirring apparatus, electronic balance,
Refrigerator, microtome etc..
3.5 other materials: syringe, test tube, gastric perfusion needle, beaker, gauze, wide mouthed bottle, cotton swab, pipettor, scalpel, curved
Pincers, blood taking tube etc..
4 experimental techniques
72 healthy male SD rats are selected in 4.1 animal packets, are randomly divided into six groups by randomized blocks method, by 72
Rat, at random from 1-72 label, by the numbering of rat divided by 6, is grouped with remainder.Remainder is 0,1,2,3,4,5 to be denoted as
Dosage group, low dose of inventive formulation in blank group, model group, colchicine group, inventive formulation high dose group, inventive formulation
Amount group often organizes 12.Often group rat is numbered in trailer label: " " represents 1, and " " represents 5, number consecutively.
Prepared by 4.2 Experimental agents
The preparation of inventive formulation: put into after inventive formulation is weighed in 1000ml distilled water and soak 1 hour, decocting half
After hour, filter, medicinal residues are decocted 20 minutes in distilled water, filter, merge twice filtrate.Filtrate is placed in 60 DEG C of water-baths
In be condensed into containing crude drug 2g mL-Medicinal liquid, seal, be placed on 4 DEG C of Refrigerator stores standby, with 6g kg during use-1Secondary-1Fill
Stomach.
The preparation of Colchicum autumnale alkali liquor: by colchicines tablets pulverization, is configured to 0.05g L-1Colchicine suspendible
Liquid, puts into 4 DEG C of Refrigerator stores standby, with lmg kg during use-1Secondary-1Gavage.
The preparation of Monosodium urate solution: take 500mg sodium urate crystals and add 18ml normal saline, heated and stirred, be made into 20m1 dense
Degree is the Monosodium urate solution of 25mg/ml.
4.3 modeling
With reference to the method for CoderreShi etc., tested greatly at model group, colchicine group, inventive formulation with 1ml syringe
Mus right hind ankle joint dorsal part thrusts inside tibia tendon from 45 ° of directions, by the Monosodium urate solution that 0.2ml concentration is 25mg/ml
It is injected into ankle joint chamber, forms gouty arthritis model.After modeling, 2h activities in rats reduces, dysphoria, feed water inlet time
Number reduces, the substantially congested swelling of right side ankle joint, and with red, hotlist is existing, have is even lifted away from ground by right foot, it was demonstrated that modeling
Success.
4.4 animals are administered
Blank group not modeling, not medication；Model group modeling, not medication；Colchicine is given after colchicine group modeling
lmg·kg-1Secondary-1Gavage, gives four inventive formulation concentrated medicament 12g kg after inventive formulation high dose group modeling-1Secondary-1Gavage, gives inventive formulation concentrated medicament 6g kg after the modeling of dosage group in inventive formulation-1Secondary-1Gavage, this
Inventive formulation concentrated medicament 3g kg is given after invention formula low dose group modeling-1Secondary-1Gavage.Colchicine group and basis
Invention formula group is every day 1 time, is used in conjunction 7 days, and blank group and model group give to wait dosage normal saline gavage.
4.5 observation indexs and method
4.5.1 the observation of general form: the body weight of rat and change of spirit under observed and recorded, observes Rat Right lower extremity swelling and distension
Situation, and contrast with strong side.
The most pathological observation and the mensuration of cytokine: after being administered 7 days, rat is put to death, by Rat Right lower limb
Peel off below ankle joint.Take 100mg ankle joint synovial tissue, put in 2mlEP pipe, add PBS solution 1.5ml, and put into steel
Pearl, closes EP pipe, puts in tissue refiner, be homogenized 10min, take out steel ball, after put into centrifuge, 3000 turns, centrifugal
10min, with micropipettor by supernatant remove, be placed in-80 DEG C of refrigerators preserve to be detected.Residue tissue is fixed on 10%
24h in neutral formalin buffer, then with 5% nitric acid decalcification 48h, cleans for several times with water purification afterwards, can be light with pin
It is degree that pine thrusts osseous tissue, the ankle joint surrounding tissue disposed finally cuts the section that thickness is 5mm and takes out, by normal
Experimental procedure method carries out being dehydrated transparent, paraffin embedding, after section and HE dyeing, section is placed under microscope and examines
Look into, observe the change of ankle joint surrounding tissue.Centrifugal for synovial tissue of joint rear gained supernatant ELISA kit is detected sample
This concentration.
4.6 statistical method
According to the indices result surveyed of experiment, all data all use SPSS18.0 software to carry out statistical data to divide
Analysis.Measurement data mean ± standard deviationRepresent, compare between multisample group and meet normal distribution employing single factor test variance
Analyze, compare two-by-two between each group, use LSD inspection.Inspection level is a=0.05, and a=0.01, P ＜ 0.05 represents that difference is had a mind to
Justice.P ＜ 0.01 represents that difference has significant.
Effect of the present invention has obtained fully proving through clinical data, and relevant clinical data is as follows:
Clinical manifestation:
Typical onset is many wakes up with a start because of toes pain at midnight, falls ill hurried, and within about 2-3 days, pain peaks, characteristic of pain
Bite sample have an intense pain as lancinated or stinging.The substantially red and swollen heating of periarticular soft tissue, even local can not a little vibrations or quilt
Single covering.First this disease betides that the first sole of the foot toe is monarthric accounts for 60% one the 70% of total number of persons, and has more than 90% patient to exist
This position can be involved during disease；The joints such as secondly the most multiple position is sole of the foot toe, ankle, knee joint, refer to, wrist, elbow, more rare
In joints such as shoulder, hip and vertebras.Gouty arthritis recurrent exerbation can gradually affect multiple joint.Sometimes can be from the high point got involved
Joint is extracted out hydrarthrosis.Primary disease the most all can be fallen ill, but with spring and autumn morbidity at most.Before morbidity, the fewest
Number patients may occur in which that joint, the whole body is uncomfortable, tired or the local sign such as joint sting, but Most patients is without any prodrome.
During gouty arthritis outbreak, majority is showed only as local and has an intense pain, and General Symptoms is inconspicuous, and a few peoples may occur in which headache, low
Heat, erythrocyte sedimentation rate are fast, leukocyte rises high.Walk for a long time, drink, tired, infect, local joint damages, infect, operation etc.
Induction gouty arthritis.The natural history of gout typically can last for days to several weeks, and after recovery from illness, only inflammation skin region color and luster becomes
Secretly, and without any symptom.
(1), case inclusion criteria:
According to results such as clinical symptoms, sign, auxiliary examinations, formulate about acute by Americanism damp disease association in 1977
The diagnostic criteria of gouty arthritis: have specificity urate crystal in joint liquid.The most chemically or polarizing microscope confirm
Containing urate crystal in tophus.3. possess 6 persons in following 12 (clinic, laboratory, x-ray show): a acute arthritis is sent out
Make more than 1 time；B inflammatory reaction reached peak in 1 day；C monarthritis is shown effect；D diseased joints skin is kermesinus；E the 1st sole of the foot
Toe joint pain or swelling；Unilateral 1st metatarsophalangeal joints of f is got involved；G one side midtarsal joints is got involved；The suspicious tophus of h；I antihyperuricemic
Disease；J joint unsymmetry swelling (x-ray confirmation)；K is without cyst under the cortical bone of bone erosion (x-ray confirmation)；L arthritis is shown effect
During period, joint fluid microorganism culturing is negative.Selecting typical patient 30 example, the maleest 19 examples, female 11 example, the age is 60-82
Year.
(2), diagnostic criteria:
All have above-mentioned (one) described symptom, and the performance of warp knuckle fluid inspection, laboratory, x-ray checks, etc. make a definite diagnosis acute pain
Wind arthritis highlights.
(3), efficacy assessment standard:
Effective: clinical symptoms substantially alleviates, lab testing substantially changes；
Take a turn for the better: clinical symptom relief, lab testing slightly improve；
Invalid: Clinical symptom and sign, laboratory checking index do not improve.
(4), therapeutic scheme
To being diagnosed as the patient of acute gouty arthritis, treat with the Chinese medicine of the present invention, when taking, dense decoct, early
Evening is each once, each 100-150ml, and meal one hour after decoction being taken warmly, 5 days is a course for the treatment of, adds up curative effect after 2 courses for the treatment of.
(5), statistical procedures:
By above-mentioned (four) therapeutic scheme, the Chinese medicine that the oral present invention is given, add up after 2 courses for the treatment of, this invention of Clinical practice
Acute Gouty Arthritis Treated With Chinese Drugs 30 example, wherein, effective 8 examples, take a turn for the better 19 examples, and total effective rate reaches 90.0%, shows this
Bright Acute Gouty Arthritis Treated With Chinese Drugs effect is notable, has reached clinical treatment purpose, and over the course for the treatment of, has had no bright
Aobvious untoward reaction.
(6), conclusion
Being shown by above-mentioned situation, the present invention is the active drug for acute gouty arthritis, and effective percentage reaches 90.0%,
Have no side effect, stable curative effect, safe and reliable.
Claims (4)
1. the Chinese medicine treating acute gouty arthritis, it is characterised in that this Chinese medicine is by weight meter: Rhizoma Atractylodis 10-20g, yellow
Cypress 5-15g, Radix Cyathulae 20-40g, Semen Coicis 20-40g, Cortex Moutan 5-15g, Radix Paeoniae Rubra 10-20g, Bi 20-40g, Rhizoma Smilacis Glabrae 20-
40g, Radix Clematidis 15-25g, Rhizoma Cyperi (processed) 10-20g, Rhizoma Dioscoreae Nipponicae 20-40g, Fructus Chaenomelis 15-25g, Fructus Crataegi 10-20g, Flos Carthami 10-
20g, eupolyphaga 10-20g, Pheretima 10-20g, Rhizoma Corydalis 20-30g, Radix Glycyrrhizae 5-10g make.
A kind of Chinese medicine treating acute gouty arthritis the most according to claim 1, it is characterised in that this Chinese medicine is by weight
Gauge: Rhizoma Atractylodis 15g, Cortex Phellodendri 10g, Radix Cyathulae 30g, Semen Coicis 30g, Cortex Moutan 10g, Radix Paeoniae Rubra 15g, Bi 30g, Rhizoma Smilacis Glabrae 30g,
Radix Clematidis 18g, Rhizoma Cyperi (processed) 15g, Rhizoma Dioscoreae Nipponicae 30g, Fructus Chaenomelis 18g, Fructus Crataegi 15g, Flos Carthami 15g, eupolyphaga 15g, Pheretima 15g, Rhizoma Corydalis
30g, Radix Glycyrrhizae 6g make.
A kind of Chinese medicine treating acute gouty arthritis the most according to claim 1, it is characterised in that this Chinese medicine is by weight
Gauge: Rhizoma Atractylodis 10g, Cortex Phellodendri 15g, Radix Cyathulae 40g, Semen Coicis 40g, Cortex Moutan 15g, Radix Paeoniae Rubra 20g, Bi 40g, Rhizoma Smilacis Glabrae 20g,
Radix Clematidis 25g, Rhizoma Cyperi (processed) 10g, Rhizoma Dioscoreae Nipponicae 20g, Fructus Chaenomelis 25g, Fructus Crataegi 20g, Flos Carthami 10g, eupolyphaga 20g, Pheretima 10g, Rhizoma Corydalis
30g, Radix Glycyrrhizae 10g make.
A kind of Chinese medicine treating acute gouty arthritis the most according to claim 1, it is characterised in that this Chinese medicine is by weight
Gauge: Rhizoma Atractylodis 20g, Cortex Phellodendri 5g, Radix Cyathulae 20g, Semen Coicis 20g, Cortex Moutan 5g, Radix Paeoniae Rubra 10g, Bi 20g, Rhizoma Smilacis Glabrae 40g, prestige
Radix Clematidis 15g, Rhizoma Cyperi (processed) 20g, Rhizoma Dioscoreae Nipponicae 40g, Fructus Chaenomelis 15g, Fructus Crataegi 10g, Flos Carthami 20g, eupolyphaga 10g, Pheretima 20g, Rhizoma Corydalis
20g, Radix Glycyrrhizae 5g make.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110025741A (en) * | 2019-04-01 | 2019-07-19 | 广西中医药大学第一附属医院 | Four wonderful cool blood granules of one kind and preparation method thereof |
| CN110755566A (en) * | 2019-12-02 | 2020-02-07 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Traditional Chinese medicine composition and preparation and application thereof |
| CN113730521A (en) * | 2021-10-12 | 2021-12-03 | 何彦生 | Formula for treating gouty arthritis |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110025741A (en) * | 2019-04-01 | 2019-07-19 | 广西中医药大学第一附属医院 | Four wonderful cool blood granules of one kind and preparation method thereof |
| CN110755566A (en) * | 2019-12-02 | 2020-02-07 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Traditional Chinese medicine composition and preparation and application thereof |
| CN110755566B (en) * | 2019-12-02 | 2021-09-24 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Traditional Chinese medicine composition and preparation and application thereof |
| CN113730521A (en) * | 2021-10-12 | 2021-12-03 | 何彦生 | Formula for treating gouty arthritis |
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