CN108309821B - Whitening skin-care mask mud and preparation method thereof - Google Patents
Whitening skin-care mask mud and preparation method thereof Download PDFInfo
- Publication number
- CN108309821B CN108309821B CN201810236003.3A CN201810236003A CN108309821B CN 108309821 B CN108309821 B CN 108309821B CN 201810236003 A CN201810236003 A CN 201810236003A CN 108309821 B CN108309821 B CN 108309821B
- Authority
- CN
- China
- Prior art keywords
- skin
- whitening
- mask mud
- baicalin
- shearing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 84
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 239000001329 FEMA 3811 Substances 0.000 claims abstract description 42
- ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 claims abstract description 42
- 229940089953 neohesperidin dihydrochalcone Drugs 0.000 claims abstract description 42
- 235000010434 neohesperidine DC Nutrition 0.000 claims abstract description 42
- 244000183685 Citrus aurantium Species 0.000 claims abstract description 39
- 235000007716 Citrus aurantium Nutrition 0.000 claims abstract description 39
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 claims abstract description 38
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 claims abstract description 38
- 229960003321 baicalin Drugs 0.000 claims abstract description 38
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000000341 volatile oil Substances 0.000 claims abstract description 30
- 239000001814 pectin Substances 0.000 claims abstract description 27
- 235000010987 pectin Nutrition 0.000 claims abstract description 27
- 229920001277 pectin Polymers 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000005995 Aluminium silicate Substances 0.000 claims abstract description 17
- 235000012211 aluminium silicate Nutrition 0.000 claims abstract description 17
- 239000000440 bentonite Substances 0.000 claims abstract description 17
- 229910000278 bentonite Inorganic materials 0.000 claims abstract description 17
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims abstract description 17
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 15
- 229920000136 polysorbate Polymers 0.000 claims abstract description 12
- VGEREEWJJVICBM-UHFFFAOYSA-N phloretin Chemical compound C1=CC(O)=CC=C1CCC(=O)C1=C(O)C=C(O)C=C1O VGEREEWJJVICBM-UHFFFAOYSA-N 0.000 claims description 44
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 35
- 238000010008 shearing Methods 0.000 claims description 26
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims description 25
- 229930003944 flavone Natural products 0.000 claims description 25
- 235000011949 flavones Nutrition 0.000 claims description 25
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 25
- 150000002212 flavone derivatives Chemical class 0.000 claims description 24
- 235000000228 Citrus myrtifolia Nutrition 0.000 claims description 23
- 235000016646 Citrus taiwanica Nutrition 0.000 claims description 23
- ZWTDXYUDJYDHJR-UHFFFAOYSA-N (E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)-2-propen-1-one Natural products OC1=CC(O)=CC=C1C=CC(=O)C1=CC=C(O)C=C1O ZWTDXYUDJYDHJR-UHFFFAOYSA-N 0.000 claims description 22
- 235000008708 Morus alba Nutrition 0.000 claims description 22
- YQHMWTPYORBCMF-UHFFFAOYSA-N Naringenin chalcone Natural products C1=CC(O)=CC=C1C=CC(=O)C1=C(O)C=C(O)C=C1O YQHMWTPYORBCMF-UHFFFAOYSA-N 0.000 claims description 22
- 240000000249 Morus alba Species 0.000 claims description 21
- 239000008518 lycium barbarum polysaccharide Substances 0.000 claims description 18
- 229940092782 bentonite Drugs 0.000 claims description 15
- 229960000829 kaolin Drugs 0.000 claims description 15
- 235000011187 glycerol Nutrition 0.000 claims description 12
- 239000008213 purified water Substances 0.000 claims description 11
- 230000008569 process Effects 0.000 claims description 6
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 5
- 229920000053 polysorbate 80 Polymers 0.000 claims description 5
- 235000012216 bentonite Nutrition 0.000 claims description 4
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 46
- 102000003425 Tyrosinase Human genes 0.000 abstract description 20
- 108060008724 Tyrosinase Proteins 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 18
- 230000015572 biosynthetic process Effects 0.000 abstract description 14
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 abstract description 13
- 239000003960 organic solvent Substances 0.000 abstract description 13
- 230000003827 upregulation Effects 0.000 abstract description 12
- 230000002401 inhibitory effect Effects 0.000 abstract description 9
- 230000008901 benefit Effects 0.000 abstract description 5
- 230000002028 premature Effects 0.000 abstract description 5
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract description 4
- 239000002243 precursor Substances 0.000 abstract description 4
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract description 4
- 238000009776 industrial production Methods 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 239000011499 joint compound Substances 0.000 description 62
- 210000003491 skin Anatomy 0.000 description 38
- 238000012360 testing method Methods 0.000 description 21
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 18
- 239000000203 mixture Substances 0.000 description 14
- 230000001815 facial effect Effects 0.000 description 10
- 230000005764 inhibitory process Effects 0.000 description 10
- 239000000523 sample Substances 0.000 description 9
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- -1 flavonoid compounds Chemical class 0.000 description 7
- 230000036564 melanin content Effects 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 230000003078 antioxidant effect Effects 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 5
- 229930003935 flavonoid Natural products 0.000 description 5
- 235000017173 flavonoids Nutrition 0.000 description 5
- 229910001385 heavy metal Inorganic materials 0.000 description 5
- 229920001282 polysaccharide Polymers 0.000 description 5
- 239000005017 polysaccharide Substances 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 244000241838 Lycium barbarum Species 0.000 description 4
- 235000015459 Lycium barbarum Nutrition 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 238000007865 diluting Methods 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- 210000002752 melanocyte Anatomy 0.000 description 4
- 239000000729 antidote Substances 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 3
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 3
- 229960004705 kojic acid Drugs 0.000 description 3
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 3
- 230000000069 prophylactic effect Effects 0.000 description 3
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 102100031413 L-dopachrome tautomerase Human genes 0.000 description 2
- 235000015468 Lycium chinense Nutrition 0.000 description 2
- 229940126902 Phlorizin Drugs 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000001066 destructive effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 230000003859 lipid peroxidation Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000036542 oxidative stress Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- IOUVKUPGCMBWBT-UHFFFAOYSA-N phloridzosid Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 IOUVKUPGCMBWBT-UHFFFAOYSA-N 0.000 description 2
- IOUVKUPGCMBWBT-GHRYLNIYSA-N phlorizin Chemical compound O[C@@H]1[C@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 IOUVKUPGCMBWBT-GHRYLNIYSA-N 0.000 description 2
- 235000019139 phlorizin Nutrition 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 210000001626 skin fibroblast Anatomy 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241001061264 Astragalus Species 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 102000030523 Catechol oxidase Human genes 0.000 description 1
- 108010031396 Catechol oxidase Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 241000218213 Morus <angiosperm> Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 206010036087 Polymorphic light eruption Diseases 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- 241000207929 Scutellaria Species 0.000 description 1
- 206010040829 Skin discolouration Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000006533 astragalus Nutrition 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 108010051081 dopachrome isomerase Proteins 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000003891 ferrous sulphate Nutrition 0.000 description 1
- 239000011790 ferrous sulphate Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000000640 hydroxylating effect Effects 0.000 description 1
- 208000000069 hyperpigmentation Diseases 0.000 description 1
- 230000003810 hyperpigmentation Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 230000003061 melanogenesis Effects 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- ARGKVCXINMKCAZ-UZRWAPQLSA-N neohesperidin Chemical group C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@H](O)[C@@H](O)[C@H](C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UZRWAPQLSA-N 0.000 description 1
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 238000007427 paired t-test Methods 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical group N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses whitening skin-care mask mud and a preparation method thereof, wherein the whitening skin-care mask mud comprises the following components in percentage by weight: 0.1-10% of neohesperidin dihydrochalcone, 0.1-10% of baicalin, 0.1-5% of daidai pectin, 0.1-2% of dai essential oil, 10-20% of an organic solvent, 10-15% of kaolin, 5-10% of bentonite, 801-5% of tween and the balance of water. In the components of the whitening and skin-protecting mask mud, the neohesperidin dihydrochalcone and the baicalin are compounded according to the weight percentage, so that the active site of tyrosinase can be damaged, the tyrosinase loses the effect on melanin precursor tyrosine, and the aim of inhibiting the formation of melanin is fulfilled. In addition, the neohesperidin dihydrochalcone and baicalin can effectively inhibit MMP-1 gene up-regulation caused by infrared rays, so that the premature senility of human skin can be effectively prevented. The preparation method of the whitening and skin-care mask mud has the advantages of easily obtained raw materials, low cost, simple method and easy realization of industrial production.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to whitening and skin-care mask mud and a preparation method thereof.
Background
Skin whitening is one of the traditional aesthetic standards of Chinese females, many females hope to achieve the whitening effect by using a functional whitening skin care product, the whitening product has great market value at home and abroad, but the infrared ray causes the up-regulation of MMP-1 gene in a human body, the MMP-1 is a regulation gene of collagen degrading enzyme, and the degradation of collagen is a main factor of the premature senility of human skin. Meanwhile, the hyperpigmentation of melanin causes skin problems such as spots, freckles, etc., and affects the skin quality of the skin.
The currently accepted process of melanogenesis can be briefly expressed as: tyrosine-dopa-dopaquinone-dopachrome-dihydroxyindole-ketoindole-melanin, the formed melanin is eumelanin or eumelanin, and the skin pigment mainly consists of the eumelanin. Since the formation of melanin occurs mainly in melanocytes, studies on the mechanism of melanin formation in melanocytes have shown that the formation of melanin is mainly due to the inclusion of four enzymes in melanocytes: tyrosinase, dopachrome tautomerase (TRP-2), peroxidase and DI-IICA oxidase (TRP-1), which stabilize tyrosinase activity, which is different from tyrosinase of mice, mushrooms, etc., in human body, and the above four enzymes act individually or synergistically. Inhibition of various melanin-forming enzymes is important if true skin lightening is to be achieved.
Among the various melanin-forming enzymes mentioned above, tyrosinase is a polyphenol oxidase, which belongs to the class of redox enzymes that catalyze mainly two different types of reactions: hydroxylating the monophenol to generate an ortho-dihydroxy compound, and oxidizing the ortho-diphenol to generate ortho-diphenoquinone. In both reactions, oxygen free radicals participate. Tyrosinase is the main rate-limiting enzyme in the process of melanin formation, and the size of the enzyme activity determines the amount of melanin formation. Therefore, the purpose of inhibiting the formation of melanin can be achieved by destroying the active site of tyrosinase.
Disclosure of Invention
The invention provides whitening and skin-care mask mud and a preparation method thereof, and aims to solve the technical problems that the skin quality is deteriorated and blackened due to the formation of melanin in the skin, and the skin is senilism and pigmentation are caused by infrared rays.
The technical scheme adopted by the invention is as follows:
the whitening skin-care mask mud comprises the following components in percentage by weight: 0.1-10% of neohesperidin dihydrochalcone, 0.1-10% of baicalin, 0.1-5% of daidai pectin, 0.1-2% of dai essential oil, 10-20% of an organic solvent, 10-15% of kaolin, 5-10% of bentonite, 801-5% of tween and the balance of water.
Further, the paint comprises the following components in percentage by weight: 0.6-8% of neohesperidin dihydrochalcone, 0.1-5% of baicalin, 0.5-5% of daidai pectin, 0.1-2% of dai essential oil, 10-20% of an organic solvent, 10-15% of kaolin, 5-10% of bentonite, 801-5% of tween and the balance of water.
Furthermore, the whitening skin-care facial mask mud also comprises mulberry leaf flavone, and the weight percentage of the mulberry leaf flavone is 0.1-5%.
Furthermore, the whitening skin-care facial mask mud also comprises mulberry leaf flavone, and the weight percentage of the mulberry leaf flavone is 0.1-3%.
Further, the whitening and skin-care mask mud also comprises the following components in percentage by weight: 0.1 to 5 percent of phloretin and 0.1 to 5 percent of lycium barbarum polysaccharide.
Further, the whitening and skin-care mask mud also comprises the following components in percentage by weight: 0.5 to 5 percent of phloretin and 0.1 to 3 percent of lycium barbarum polysaccharide.
Further, the organic solvent is one or more of glycerol, propylene glycol, butanediol and diethylene glycol.
According to another aspect of the invention, the preparation method of the whitening and skin-care mask mud comprises the following steps: placing an organic solvent, water and daidai pectin in a shearing machine, adding Tween 80 in the shearing process, continuing shearing, adding kaolin, bentonite, neohesperidin dihydrochalcone and baicalin, and finally adding dai essential oil to obtain the whitening and skin-care facial mask mud.
The invention has the following beneficial effects:
in the components of the whitening and skin-protecting mask mud, the neohesperidin dihydrochalcone and the baicalin are compounded, so that destructive inhibition can be generated on tyrosinase, namely, the active part of the tyrosinase is damaged, the tyrosinase loses the effect on melanin precursor tyrosine, and the aim of inhibiting melanin formation is fulfilled. Meanwhile, the neohesperidin dihydrochalcone and baicalin can effectively inhibit MMP-1 gene up-regulation caused by infrared rays, so that the premature senility of human skin can be effectively prevented. In addition, the bitter orange essential oil is added, so that the whitening and skin-care mask mud has a stronger antibacterial effect; the citrus aurantium pectin is an antidote and a prophylactic agent for heavy metals, can reduce the content of heavy metals introduced by air, food and other cosmetics in skin, and can prolong the antibacterial action and the bacteriostatic cycle of citrus aurantium essential oil when combined with the citrus aurantium essential oil; the solubility of the neohesperidin dihydrochalcone and the baicalin in a normal-temperature water solution is limited, the neohesperidin dihydrochalcone and the baicalin are easy to separate out to influence the whitening effect, and the addition of the citrus aurantium pectin can enhance the stability of the whole system and further enhance the whitening effect of the skin-care mask mud.
The preparation method of the whitening and skin-care mask mud provided by the invention has the advantages of easily obtained raw materials, low cost, simple method and easy realization of industrial production. The traditional preparation method of the mask mud comprises the steps of heating a system to improve the solubility of each component, reducing the temperature of the system, and then performing split charging and blending. The traditional method wastes energy sources, has long preparation period, and can destroy the effective components of each component in the heating process to a certain extent, thereby influencing the whitening effect of the facial mask mud. The invention utilizes the high-speed shearing machine to shear and dissolve each component, avoids the heating process of the system, does not damage each component, reduces the energy loss and shortens the preparation period.
In addition to the objects, features and advantages described above, other objects, features and advantages of the present invention are also provided. The present invention will be described in further detail below.
Detailed Description
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail with reference to examples.
The preferred embodiment of the invention provides whitening skin-care mask mud which comprises the following components in percentage by weight: 0.1-10% of neohesperidin dihydrochalcone, 0.1-10% of baicalin, 0.1-5% of daidai pectin, 0.1-2% of dai essential oil, 10-20% of an organic solvent, 10-15% of kaolin, 5-10% of bentonite, 801-5% of tween and the balance of water.
In the components of the whitening and skin-protecting mask mud, neohesperidin dihydrochalcone is one of plant-derived flavonoid compounds, and is mainly used as a sweetener in the food industry at present. Researches show that the neohesperidin dihydrochalcone has better effect of inhibiting the neuraminidase than beta-arbutin, kojic acid and VC. Neohesperidin dihydrochalcone is a glycoside flavonoid, and a flavonoid compound is a natural substance extracted from plants. Many flavone glycosides are peculiar to Rutaceae plants, and the synthesis starting material of neohesperidin dihydrochalcone is neohesperidin which is extracted and refined from bitter orange. The literature indicates that the tyrosinase inhibition rate of the neohesperidin dihydrochalcone is the highest compared with the beta-arbutin, VC and kojic acid. The inhibitory capacity of the neohesperidin dihydrochalcone on melanin generation is close to that of VC and kojic acid and is 3 times of that of beta-arbutin, so that the neohesperidin dihydrochalcone is a novel whitening agent with application potential and can be used as a main active ingredient in the development of novel whitening skin care products.
In the components of the whitening skin-care mask mud, baicalin is a flavonoid compound extracted from astragalus, and the antioxidant activity of scutellaria is proved to be greater than that of vitamin E by an in vitro oxygen radical absorption capacity method, so that the baicalin is a natural strong antioxidant except vitamin E, vitamin C and carotene. The baicalin can inhibit lipid peroxidation of mouse brain cells induced by ascorbic acid and ferrous sulfate, and reduce oxygen consumption of brain nerves stimulated by ADP by using malic acid and glutamic acid as substrates, thereby reducing lipid peroxidation.
Among the components of the whitening skin-care mask mud, the method for extracting the daidaidai essential oil comprises the steps of extracting the daidaidai essential oil from the daidai flower under the extraction conditions of temperature of 40 ℃, pressure of 35Mpa, carbon dioxide flow rate of 20kg/h, bulk density of the dai flower of 0.33g/ml, extract yield of 3.0-3.3%, and the extracted dai essential oil is light yellow clear liquid in appearance and pure in fragrance. The main active ingredient of daidaidai essential oil is limonene, and pharmacological experiments prove that daidai essential oil is a natural bacteriostatic agent and has a strong antibacterial effect.
Among the components of the whitening skin-care mask mud, the method for extracting citrus aurantium pectin comprises the steps of taking citrus aurantium flavone extraction residues, adding 10 times of pure water, adjusting the pH value to 1.5-2 by using citric acid, extracting for 2 hours at 85 ℃, filtering, concentrating filtrate to 2 times of the extraction residues, adjusting the alcohol degree to 55% -60% by using absolute ethyl alcohol, collecting precipitates, drying in vacuum, and crushing to obtain the citrus aurantium pectin, wherein the extracted citrus aurantium pectin is white powder. The citrus aurantium pectin is a purely natural stabilizer and thickener, is also an antidote and a prophylactic agent for heavy metals, can prolong the action of antibiotics, and is matched with citrus aurantium essential oil to obviously enhance the antibacterial capacity and the antibacterial period of the citrus aurantium essential oil.
In the components of the whitening skin-care mask mud, kaolin and bentonite have plasticity, wet soil can be molded into various shapes without being broken and can be kept unchanged for a long time, other components can be bonded together and molded into various shapes without being deformed, and the whitening skin-care mask mud is convenient to use.
In the components of the whitening and skin-care mask mud, Tween 80 is used as an emulsifier and is used as a solubilizer for insoluble components in water in the components of the whitening and skin-care mask mud, so that the solubility of the main components is enhanced.
In the components of the whitening and skin-protecting mask mud, the neohesperidin dihydrochalcone and the baicalin are compounded according to the weight percentage, so that destructive inhibition can be generated on tyrosinase, namely, the active part of the tyrosinase is damaged, the tyrosinase loses the effect on melanin precursor tyrosine, and the purpose of inhibiting melanin formation is achieved. Meanwhile, the neohesperidin dihydrochalcone and baicalin can effectively inhibit MMP-1 gene up-regulation caused by infrared rays, so that the premature senility of human skin can be effectively prevented. In addition, the bitter orange essential oil is added, so that the whitening and skin-care mask mud has a stronger antibacterial effect; the citrus aurantium pectin is an antidote and a prophylactic agent for heavy metals, can reduce the content of heavy metals introduced by air, food and other cosmetics in skin, and can prolong the antibacterial action and the bacteriostatic cycle of citrus aurantium essential oil when combined with the citrus aurantium essential oil; the solubility of the neohesperidin dihydrochalcone and the baicalin in a normal-temperature water solution is limited, the neohesperidin dihydrochalcone and the baicalin are easy to separate out to influence the whitening effect, and the addition of the citrus aurantium pectin can enhance the stability of the whole system and further enhance the whitening effect of the skin-care mask mud.
Preferably, the whitening and skin-care mask mud comprises the following components in percentage by weight: 0.6-8% of neohesperidin dihydrochalcone, 0.1-5% of baicalin, 0.5-5% of daidai pectin, 0.1-2% of dai essential oil, 10-20% of an organic solvent, 10-15% of kaolin, 5-10% of bentonite, 801-5% of tween and the balance of water. More preferably, the mask mud solution of the whitening and skin-care mask mud comprises the following components in percentage by weight: 0.6-5% of neohesperidin dihydrochalcone, 0.1-1% of baicalin, 3-5% of daidai pectin, 0.1-2% of dai essential oil, 10-20% of an organic solvent, 10-15% of kaolin, 5-10% of bentonite, 801-5% of tween and the balance of water.
The components in the whitening and skin-care mask mud are compounded according to the preferred weight percentage, so that tyrosinase can be better inhibited, and the formation of melanin is inhibited; in addition, the preferable proportion of the neohesperidin dihydrochalcone and the baicalin can most effectively inhibit the MMP-1 gene up-regulation caused by infrared rays, thereby generating better inhibiting effect on the skin premature senility of human bodies; the optimal proportion of daidai essential oil and dai pectin enables the antibacterial effect of the skin care mask mud to be strongest, and enhances the stability of each component in the system to the maximum extent, so that the whitening effect is optimal.
Preferably, the whitening and skin-protecting mask mud also comprises mulberry leaf flavone, and the weight percentage of the mulberry leaf flavone is 0.1-5%. More preferably, the weight percentage is 0.1-3%. More preferably, the weight percentage is 0.1 to 1 percent.
In the components of the whitening and skin-protecting facial mask mud, the mulberry leaf flavone is a flavonoid compound extracted from mulberry trees, and can achieve antioxidant activity by improving SOD activity, reducing LPO content and changing GSH-PX level. The compounding of the mulberry leaf flavone, the neohesperidin dihydrochalcone and the baicalin can enhance the capability of destroying the active site of tyrosinase, so that the tyrosinase loses the effect on the melanin precursor tyrosine and is enhanced, and the whitening effect of the whitening skin-care mask mud is enhanced.
Preferably, the whitening and skin-care mask mud further comprises the following components in percentage by weight: 0.1 to 5 percent of phloretin and 0.1 to 5 percent of lycium barbarum polysaccharide. Still preferably, the whitening skin-care mask mud further comprises the following components in percentage by weight: 0.5 to 5 percent of phloretin and 0.1 to 3 percent of lycium barbarum polysaccharide. More preferably, the whitening and skin-care mask mud further comprises the following components in percentage by weight: phloretin 1-5 wt% and wolfberry fruit polysaccharide 0.1-1 wt%.
In the components of the whitening skin-care mask mud, phloretin is an aglycon part of phlorizin and is separated from the phlorizin by adding acid and hydrolyzing; or synthesized by corresponding chemical processes. Phloretin can inhibit excessive secretion of sebaceous gland, and can be used for treating acne with excessive secretion; can inhibit activity of melanocyte, and has strong effect in eliminating various skin color spots.
In the components of the whitening skin-care mask mud, the lycium barbarum polysaccharide is a polysaccharide compound extracted from lycium barbarum. Epidemiological data prove that the occurrence and development of skin diseases such as acne, atopic dermatitis, polymorphous light eruption, scleroderma, epidermal tumor and the like are all related to oxidative stress injury, and lycium barbarum polysaccharide can relieve the oxidative stress injury of cells through an antioxidant mechanism, maintain the dynamic balance of skin oxidation and antioxidant to repair and protect the cells.
In the components of the whitening and skin-protecting mask mud, when phloretin, lycium barbarum polysaccharide and mulberry flavone are compounded, the goal of inhibiting melanin formation can be achieved by inhibiting the biosynthesis of tyrosinase or substituting the action substrate of the tyrosinase. And the five components are combined for use by compounding with neohesperidin dihydrochalcone and baicalin, so that the source of melanin generation is thoroughly cut off, and the effect of whitening skin is achieved.
Preferably, the organic solvent is one or more of glycerol, propylene glycol, butanediol and diethylene glycol. More preferably, the organic solvent is glycerol. The organic solvent is beneficial to fully dissolving all components in the whitening and skin-care mask mud so as to bring the synergistic effect of all the components into play. The organic solvent is glycerin, which is excellent in hygroscopicity and solubility and can sufficiently dissolve the components.
Preferably, the water used in the whitening and skin-care mask mud is deionized water, and more preferably secondary purified water.
According to another aspect of the invention, the preparation method of the whitening and skin-care mask mud comprises the following steps: placing an organic solvent, water and daidai pectin in a shearing machine, adding Tween 80 in the shearing process, continuing shearing, adding kaolin, bentonite, neohesperidin dihydrochalcone and baicalin, and finally adding dai essential oil to obtain the whitening and skin-care facial mask mud. The facial mask paste also contains folium Mori flavone, phloretin and fructus Lycii polysaccharide, which are added together with neohesperidin dihydrochalcone and baicalin and sheared.
The preparation method of the whitening and skin-protecting mask mud has the advantages of easily obtained raw materials, low cost, simple method and easy realization of industrial production. The traditional preparation method of the mask mud comprises the steps of heating a system to improve the solubility of each component, reducing the temperature of the system, and then performing split charging and blending. The traditional method wastes energy sources, has long preparation period, and can destroy the effective components of each component in the heating process to a certain extent, thereby influencing the whitening effect of the facial mask mud. The invention utilizes the high-speed shearing machine to shear and dissolve each component, avoids the heating process of the system, does not damage each component, reduces the energy loss and shortens the preparation period.
Examples
The chemicals are commercially available in the following examples.
Example 1
The whitening skin-care mask mud comprises the following components in percentage by weight: neohesperidin dihydrochalcone 2%, baicalin 1%, mulberry flavone 0.5%, phloretin 3%, lycium barbarum polysaccharide 0.5%, glycerol 15%, citrus aurantium pectin 5%, citrus aurantium essential oil 1%, kaolin 15%, bentonite 10%, tween 805% and secondary purified water 42%.
The preparation method of the whitening and skin-protecting mask mud comprises the following steps: placing glycerol in a high-speed shearing machine for shearing, wherein the shearing speed is 15000 r/min, slowly adding secondary purified water in the shearing process, slowly adding citrus aurantium pectin after shearing at normal temperature for 10min, then slowly adding citrus aurantium pectin after shearing at normal temperature for 10min, slowly adding tween 80, adding kaolin, bentonite, neohesperidin dihydrochalcone, baicalin, mulberry leaf flavone, phloretin and lycium barbarum polysaccharide after shearing at normal temperature for 10min, shearing at normal temperature for 20min, and finally adding citrus aurantium essential oil for shearing for 10min to obtain the whitening skin-care mask mud.
The method is characterized in that human skin fibroblasts are taken, and the inhibition effect of 5 main components in the treated whitening and skin-care facial mask mud and the composition prepared in the example 1 on MMP-1 gene up-regulation after infrared light irradiation are tested by means of Hydrosun 500H IRA equipment. The treatment of the 5 main components is as follows:
baicalin: diluting baicalin dissolved in DMSO at 44.8mmol/ml to 10umol/ml and 25umol/ml respectively;
phloretin: diluting phloretin 50mmol/ml dissolved in DMSO to 1umol/ml, 5umol/ml, 10umol/ml respectively;
and (3) mulberry leaf flavone: diluting folium Mori flavone 50mmol/ml dissolved in DMSO to 5umol/ml and 10umol/ml respectively;
wolfberry polysaccharide: diluting 50mmol/ml Lycium barbarum polysaccharides dissolved in DMSO to 5umol/ml and 10umol/ml respectively;
neohesperidin dihydrochalcone: 710mmol/ml neohesperidin dihydrochalcone dissolved in DMSO is respectively diluted to 100umol/ml, 500umol/ml and 1 mmol/ml.
Composition proportioned in example 1: 50mmol/ml of the composition dissolved in DMSO was diluted to 5. mu. mol/ml and 10. mu. mol/ml, respectively.
Before testing, human skin fibroblasts were incubated for 24h at the indicated concentrations of each of the above ingredients, followed by 360J/cm2And the infrared ray is irradiated for 24 hours, and the infrared ray is proved to be capable of inducing gene expression without damaging the cell function. Subsequently, RNA was extracted and MMP-1mRNA was analyzed. The analysis results are shown in table 1. As is clear from the analysis data in Table 1, the compositions of 5 main components and the composition prepared in example 1 were able to inhibit the infrared light-induced MMP-1 gene up-regulation.
TABLE 15 inhibition of MMP-1 gene up-regulation by compositions of the major ingredients and the ratios of examples 1-5
Example 2
The whitening skin-care mask mud comprises the following components in percentage by weight: 8% of neohesperidin dihydrochalcone, 5% of baicalin, 0.1% of mulberry leaf flavone, 0.1% of phloretin, 0.1% of lycium barbarum polysaccharide, 20% of glycerol, 5% of daidaidai pectin, 1% of daidai essential oil, 15% of kaolin, 10% of bentonite, 805% of tween and 30.7% of secondary purified water.
The preparation method of the whitening and skin-care mask mud is the same as that of the embodiment 1.
The inhibition effect of the composition prepared in example 2 on the up-regulation of MMP-1 gene after infrared light irradiation is shown in Table 1.
Example 3
The whitening and skin-protecting mask mud comprises the following components in percentage by weight: neohesperidin dihydrochalcone 2%, baicalin 1%, mulberry leaf flavone 5%, phloretin 5%, lycium barbarum polysaccharide 5%, glycerol 20%, daidaidai pectin 5%, daidai essential oil 2%, kaolin 15%, bentonite 10%, tween 805% and secondary purified water 25%.
The preparation method of the whitening and skin-care mask mud is the same as that of the embodiment 1.
The inhibition effect of the composition prepared in example 3 on the up-regulation of MMP-1 gene after infrared light irradiation is shown in Table 1.
Example 4
The whitening and skin-protecting mask mud comprises the following components in percentage by weight: 8% of neohesperidin dihydrochalcone, 5% of baicalin, 3% of mulberry leaf flavone, 5% of phloretin, 3% of lycium barbarum polysaccharide, 20% of glycerol, 5% of daidaidai pectin, 2% of daidaidai essential oil, 10% of kaolin, 8% of bentonite, 805% of tween and 26% of secondary purified water.
The preparation method of the whitening and skin-care mask mud is the same as that of the embodiment 1.
The inhibition effect of the composition prepared in example 4 on the up-regulation of MMP-1 gene after infrared light irradiation is shown in Table 1.
Example 5
The whitening and skin-protecting mask mud comprises the following components in percentage by weight: 10% of neohesperidin dihydrochalcone, 10% of baicalin, 5% of mulberry leaf flavone, 5% of phloretin, 5% of lycium barbarum polysaccharide, 20% of glycerol, 5% of daidaidai pectin, 2% of daidaidai essential oil, 10% of kaolin, 5% of bentonite, 801% of tween and 22% of secondary purified water.
The preparation method of the whitening and skin-care mask mud is the same as that of the embodiment 1.
The inhibition effect of the composition prepared in example 5 on the up-regulation of MMP-1 gene after infrared light irradiation is shown in Table 1.
In order to verify the whitening effect of the product, the following comparative test formula is carried out for a comparative experiment:
formula 1: the mulberry leaf flavone, phloretin and lycium barbarum polysaccharide are respectively replaced by the same amount of second-level purified water, and the composition and preparation method of other components are the same as those in example 1.
And (2) formula: neohesperidin dihydrochalcone and baicalin were replaced with the same amount of second-stage purified water, and the composition and preparation method of the other components were the same as those in example 1.
And (3) formula: the composition and preparation of all components are the same as in example 1.
Volunteers: randomly selecting 30 healthy male and female volunteers, wherein the male and female volunteers are 18-65 years old, have no serious system diseases, no immune defects or autoimmune diseases, have no allergic diseases, do not use various cosmetics and the like during a test period, and can finish the use of specified samples according to experimental requirements. The experimental method comprises the following steps: the volunteers are divided into 3 groups according to the formula, 10 persons are in each group, the 3 groups of the formula are subjected to a trial test on the volunteers for 28 days, the volunteers are used for 1 time every other day at night, and the trial part is the face. Testing an instrument: a skin elasticity CotometerMPA580 host manufactured by CK company, germany; skin melanin mexamettmx 18 test probe manufactured by CK company, germany. Face test conditions: the face test was performed indoors with no intense sunlight or direct lighting. Whitening products (including other cosmetics, external medicines or internal health care products) cannot be used 2-3 days before the test. The subjects required a uniform cleansing of facial skin and a clean wipe with dry tissue prior to testing.
Based on the principle of spectral absorption, the content of melanin in the skin is determined by measuring the reflection amount of light with a specific wavelength irradiated on the skin of a human body. The test probe of the pigment detector consists of a light source emitter and a light source receiver, and a spring is additionally arranged to keep the pressure on the skin constant during detection. The transmitter of the probe emits light with three wavelengths of 568nm, 660nm and 880nm to the surface of the skin, and the receiver measures the light reflected by the skin. Since the amount of emitted light is constant, the amount of light absorbed by the skin can be measured, and the amount of melanin in the skin can be measured. The data in table 2 are the skin melanin content determined.
TABLE 2 comparison of melanin content (%)
The data from the 3 formulations above were subjected to paired T-test using span 17.0, with the following results:
formula 1:
paired sample statistics
Correlation coefficient of paired samples
Paired sample testing
From the above data, it can be seen that the mean value of skin melanin content of the volunteers after the 28-day test period of formula 1 decreased by 11.3, and the skin whitening tendency was significant (P < 0.05).
And (2) formula:
paired sample statistics
Correlation coefficient of paired samples
Paired sample testing
From the above data, it can be seen that the mean value of skin melanin content of the volunteers after the 28-day test period of formula 2 decreased by 11.1, and the skin whitening trend was significant (P < 0.05).
And (3) formula:
paired sample statistics
Correlation coefficient of paired samples
Paired sample testing
From the above data, it can be seen that the mean value of skin melanin content of the volunteers after the 28-day test period of formula 3 decreased by 21.7, and the skin whitening tendency was significant (P < 0.05).
The above experimental results show that the skin melanin content of the volunteers is reduced after the test period of 28 days by the 3 test formulas, and the skin whitening trend is obvious, wherein the skin melanin content of the volunteers is reduced most obviously after the test period of 28 days by the formula 3, and the effect is obviously better than that of the former two groups of formulas. Consumer tests show that the whitening skin-care mask mud has an obvious skin-whitening effect by combining and compounding 5 main components of neohesperidin dihydrochalcone, baicalin, mulberry leaf flavone, phloretin and lycium barbarum polysaccharide, and the whitening effect is superior to that of a formula in which neohesperidin dihydrochalcone and baicalin are compounded alone or a formula in which mulberry leaf flavone, phloretin and lycium barbarum polysaccharide are compounded alone.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (1)
1. The whitening skin-care mask mud is characterized by comprising the following components in percentage by weight:
8% of neohesperidin dihydrochalcone, 5% of baicalin, 3% of mulberry leaf flavone, 5% of phloretin, 3% of lycium barbarum polysaccharide, 20% of glycerol, 5% of daidaidai pectin, 2% of daidaidai essential oil, 10% of kaolin, 8% of bentonite, 805% of tween and 26% of secondary purified water;
the preparation method of the whitening and skin-care mask mud comprises the following steps:
placing glycerol in a high-speed shearing machine for shearing, wherein the shearing speed is 15000 r/min, slowly adding secondary purified water in the shearing process, slowly adding citrus aurantium pectin after shearing at normal temperature for 10min, then slowly adding citrus aurantium pectin after shearing at normal temperature for 10min, slowly adding tween 80, adding kaolin, bentonite, neohesperidin dihydrochalcone, baicalin, mulberry leaf flavone, phloretin and lycium barbarum polysaccharide after shearing at normal temperature for 10min, shearing at normal temperature for 20min, and finally adding citrus aurantium essential oil for shearing for 10min to obtain the whitening skin-care mask mud.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810236003.3A CN108309821B (en) | 2018-03-21 | 2018-03-21 | Whitening skin-care mask mud and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810236003.3A CN108309821B (en) | 2018-03-21 | 2018-03-21 | Whitening skin-care mask mud and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108309821A CN108309821A (en) | 2018-07-24 |
| CN108309821B true CN108309821B (en) | 2020-12-29 |
Family
ID=62898191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810236003.3A Active CN108309821B (en) | 2018-03-21 | 2018-03-21 | Whitening skin-care mask mud and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108309821B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020024706B1 (en) * | 2018-07-31 | 2023-04-04 | L'oreal | COMPOSITION FOR SUN PROTECTION, USE OF A COMPOSITION AND PROCESS FOR MANUFACTURING A COMPOSITION |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017058594A1 (en) * | 2015-10-01 | 2017-04-06 | Senomyx, Inc. | Compounds useful as modulators of trpm8 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102525853B (en) * | 2011-12-23 | 2013-06-05 | 广州市娇兰化妆品有限公司 | Compound natural plant extract with spot-removing function and preparation method and application thereof |
| US8765693B2 (en) * | 2012-08-13 | 2014-07-01 | L'oreal | Method of inhibiting premature aging of human skin caused by exposure to infrared radiation |
| US9669242B2 (en) * | 2013-07-01 | 2017-06-06 | L'oreal | Compositions containing at least two phenolic compounds, a lipid-soluble antioxidant and at least one hydrotrope for cosmetic use |
| CN103340795A (en) * | 2013-07-05 | 2013-10-09 | 上海珍馨化工科技有限公司 | Radix scutellariae toner |
| CN103845235A (en) * | 2014-02-13 | 2014-06-11 | 上海珍馨化工科技有限公司 | Whitening cosmetic |
| CN104490617B (en) * | 2014-11-24 | 2017-06-16 | 佛山市金骏康健康科技有限公司 | Dihydrochalcone glucosides is used as whitening, the purposes of the dark and gloomy skin quality active ingredient of improvement |
| CN105943433A (en) * | 2016-05-11 | 2016-09-21 | 杭州西顿生物科技有限公司 | Skin-whitening composition as well as preparation method and applications thereof |
-
2018
- 2018-03-21 CN CN201810236003.3A patent/CN108309821B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017058594A1 (en) * | 2015-10-01 | 2017-04-06 | Senomyx, Inc. | Compounds useful as modulators of trpm8 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108309821A (en) | 2018-07-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101041403B1 (en) | Cosmetic Composition for Anti-oxidation and Whitening | |
| KR102493443B1 (en) | Cosmetic composition comprising extracts extracted with an eco-friendly natural eutectic solvent | |
| KR101121980B1 (en) | Manufacturing Method for Extracts of Leaves And the Leaves Using the Same and Cosmetic Composition Containing the Same | |
| KR101898250B1 (en) | Cosmetic composition for skin whitening comprising the Ilex integra extract | |
| CN108309821B (en) | Whitening skin-care mask mud and preparation method thereof | |
| KR101220494B1 (en) | Cosmetic Composition for Skin Whitening Comprising Liriope Seed Extracts | |
| CN108186390B (en) | Whitening skin-care essence and preparation method thereof | |
| KR20140096738A (en) | Soup comprising the extract of cinamomum camphora siebi and skin lightning agent | |
| CN108210371B (en) | Whitening skin-care mask and preparation method thereof | |
| CN108186475B (en) | Whitening skin care emulsion and preparation method thereof | |
| KR100898307B1 (en) | Cosmetic composition with the antioxidant effect protecting skins aging | |
| KR102062036B1 (en) | Cosmetic composition for skin whitening and anti-wrinkle comprising extract of fruit and vegetables as effective component | |
| CN101766691B (en) | Artocarpus hypargyreus hance extract and preparation method and application thereof | |
| KR100466379B1 (en) | Composition for skin whitening | |
| KR101854766B1 (en) | Skin whitening complex containing trihydroxyisoflavone and glycyrrhiza uralensis extracts | |
| JPH0987164A (en) | Skin preparation for external use | |
| KR102068482B1 (en) | Cosmetic composition comprising extract of avocado and morus alba bark | |
| KR20090091511A (en) | Whitening cosmetic composition | |
| KR101740373B1 (en) | Composition for improving skin containing callus of Broussonetia plant | |
| KR20030004499A (en) | Cosmetic for skin whitening containing a herb extract with inhibitory activity of melanin formation | |
| CN108403537A (en) | A kind of skin whitening cosmetic composition and its application | |
| KR102557359B1 (en) | Cosmetic composition comprising citron residue extract and manufacturing method thereof | |
| KR100190989B1 (en) | Water soluble fraction extracts of pinelliae tuber having improved skin whitening effects by removing darkening components and a composition for improvining freckles and skin whitening containing thereof | |
| KR102556457B1 (en) | A whitening composition derived from natural products containing a large amount of lipoic acid | |
| TWI287008B (en) | Extract obtained from Pododcarpus spp. and method for preparing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20201216 Address after: 417100 Loudi hi tech Industrial Development Zone, Loudi City, Hunan Province Applicant after: LIANYUAN KANGBIOTECH Co.,Ltd. Applicant after: Lianyuan Kangcheng Agricultural Technology Development Co.,Ltd. Address before: 417100 Dong Xuan village, Lianyuan Economic Development Zone, Loudi, Hunan Applicant before: LIANYUAN KANGBIOTECH Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 417100 Loudi hi tech Industrial Development Zone, Loudi City, Hunan Province Patentee after: LIANYUAN KANGBIOTECH CO.,LTD. Patentee after: Lianyuan Kangcheng Agriculture and Forestry Technology Development Co.,Ltd. Address before: 417100 Loudi hi tech Industrial Development Zone, Loudi City, Hunan Province Patentee before: LIANYUAN KANGBIOTECH CO.,LTD. Patentee before: Lianyuan Kangcheng Agricultural Technology Development Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder |