CN108309503A - A kind of silicon rubber hernia reparation sticking patch - Google Patents

A kind of silicon rubber hernia reparation sticking patch Download PDF

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Publication number
CN108309503A
CN108309503A CN201810082039.0A CN201810082039A CN108309503A CN 108309503 A CN108309503 A CN 108309503A CN 201810082039 A CN201810082039 A CN 201810082039A CN 108309503 A CN108309503 A CN 108309503A
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hernia
sticking patch
repairs
silicon rubber
body part
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CN201810082039.0A
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Chinese (zh)
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张士丰
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Individual
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063Implantable repair or support meshes, e.g. hernia meshes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063Implantable repair or support meshes, e.g. hernia meshes
    • A61F2002/0068Implantable repair or support meshes, e.g. hernia meshes having a special mesh pattern
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable

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  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

The invention discloses a kind of silicon rubber hernias to repair sticking patch, which includes that can cut shape sticking patch and preform composite patch, and preform composite patch includes arch sticking patch and round hernia plug.It includes mesh, elastic fibrous layer and body part that the hernia of the present invention, which repairs sticking patch, and mesh is evenly distributed in body part, and it is in net distribution that elastic fibrous layer, which is embedded in body part and in body part,;Body part is made of silicon rubber.The hernia of the present invention repairs sticking patch tensile strength and is more than 30MPa, and elongation rate of tensile failure is more than 300%, and bursting strength is more than 30kPa.The silicon rubber hernia of the present invention repairs sticking patch and can be used for treating various hernias, including abdominal hernia, indirect inguinal hernia, umbilical hernia, femoral hernia, incisional hernia, pour hernie parastomiale, hiatal hernia.

Description

A kind of silicon rubber hernia reparation sticking patch
Technical field
The invention belongs to the application fields of bio-medical material, are related to a kind of silicon rubber hernia reparation sticking patch.
Background technology
Hernia (disease), is commonly called as hernia, is to pass through human body since tissue or an organ part have left original position Certain defects, gap and weakness enter another position, to generate the dysfunction of some internal organs.Hernia is surgical common disease And frequently-occurring disease, include mainly:Abdominal hernia, indirect inguinal hernia, umbilical hernia, femoral hernia, incisional hernia, pour hernie parastomiale, hiatal hernia etc..Hernia is A kind of disease that non-operative treatment cannot be cured thoroughly, surgeon have struggled one for perfect operation method and material A more centuries.Common therapy includes at present:1. hernia bandage;2. herbal treatment;3. injection closing;4. surgical operation;⑤ Herniorrhaphy etc..It is most widely used at present with herniorrhaphy.
The appearance of Lichtenstein neoplastys in 1986 opens the chapter of tension-free hernioplasty, with 1% it is low multiple Hair rate becomes the goldstandard of hernia repairing, and by development in more than 20 years, technology was continuously improved, material is constantly updated.Come at present It says, herniorrhaphy is the unique selection for curing abdominal hernia.Herniorrhaphy refers to that can be divided into traditional hernia by operative treatment hernia and repair Mend art and hernia sticking patch strain less repair.At present strain less repair have become clinician treat abdominal hernia taken it is normal Art formula is advised, and it is tension-free hernioplasty and laparoscopic surgery implantation material that hernia, which repairs sticking patch,.
Hernia repairs patching material and is divided into two major classes:One kind is bioartificial materials' sticking patch-nonabsorable material, with poly- It is basic core, including propene polymer patch, expanded polytetrafluoroethylsealing sticking patch, polyester patches etc. to close object;Another kind of is biological sticking patch, Its based on biological nature material, have human body corium, the small intestinal submucosa of pig, pig corium etc..Currently, with artificial bio-membrane Material patch is most widely used.Such as, patent No.CN 102908676A disclose a kind of compound hernia benefits of hollow type PP/PVDF Piece and preparation method thereof, wherein sticking patch are the hollow out tablet of three-layer thin-film composite construction, including:The polypropylene film on upper layer, The polyvinylidene difluoride film of lower layer and intermediate adhesive layer.Patent No.CN 102379729A disclose a kind of laparoscopic hernia Repair mesh is the netted curved surface sheet body that two sides is respectively inner concave and arcuate surface, the netted braiding which is two layers or more Object can be one kind in nonabsorable material such as polypropylene, polyethylene, polyester, polyurethane, polyamide and polytetrafluoroethylene (PTFE) Or it is a variety of, it is preferable with polypropylene;Can also be absorbable material, such as artificial or biosynthesis aliphatic polyester.For another example, patent No.CN 106880874A disclose a kind of manually compound hernia paster and preparation method thereof, and the hernia paster is polylactic acid The nano-fiber material of co-glycolic acid and collagen composite;Containing polylactide glycolic acid copolymer and collagen by fixing solvent Dissolving is prepared using the method for conjugation electrostatic spinning.Patent No.CN203564378U discloses a kind of hernia mesh plug, institute It is fill-type net plug to state hernia mesh plug, and the material for netting plug is that polypropylene for medical article monofilament works out screen cloth.
In conclusion it is basic material that the existing hernia reparation sticking patch overwhelming majority, which is with polymer,.But with amount for surgical Increase, common complication also becomes increasingly conspicuous, although it is bad anti-still to solve these by constantly transformation modus operandi It answers, more typical has:1, the risk (such as causing varicocele lesion) of spermatic cord;2, easily there is rejection, cause to hinder Mouthfeel contaminates, and causes pain;3, it is easy and internal capillary adhesion;4, easily cause to shift and corrode;5, sticking patch is not shown under x-ray Shadow can not judge whether to shift or deform.The above adverse reaction often increases the pain of patient, extends the hospital stays, is serious Influence the quality of life of patient.Serious sticking patch infection need to generally take out sticking patch after occurring simultaneously, so as to cause operative failure, Again difficulty is brought to operation.Therefore, expect a kind of Small side effects, the hernia that can mitigate above-mentioned adverse reaction repairs sticking patch.
Silicon rubber is a special synthetic rubber, it is by dimethylsiloxane monomer and other organic silicon monomers, in acidity Or a kind of linear superpolymer aggregated under basic catalyst effect.It is many excellent that the architectural characteristic of silicon rubber makes it show Performance:1. hydrophobicity, silicon rubber in the shape of a spiral, makes silica list bond polarity cancel out each other, and side chain due to its molecular backbone R be typically all low polarity or nonpolarity so that entire macromolecular polarity is very low, to show hydrophobicity;2. heat resistance, one As silicon rubber can the long-term work at 200 DEG C;3. the brittleness temperature of cold resistance, universal silicon rubber is -60 DEG C of (general organosilicons Rubber becomes fragile at -50 DEG C), and the % phenyl siloxane rubbers of molecule containing 7.5g are still flexible at -112 DEG C;4. good bio-compatible Property, tasteless nontoxic, excellent physiological inertia, resistance to biological aging are reacted minimum to tissue, will not be drawn after being implanted into tissue Foreign body reaction is played, is not inflamed to surrounding tissue;Acceptable with excellent biology, not carcinogenic, use temperature range is wide, It can high-temperature sterilization.Based on the above performance so that silicon rubber becomes a kind of typical medical macromolecular materials.Especially medical silicon As application of the glue in pacemaker, heart valve, not only makes into thousands of patient and obtain new life, but also be it The exploitation of his medical product plays prodigious facilitation.60~seventies of 20th century, external there are many medical grade silicon rubbers Product (silicon rubber breast, articulations digitorum manus, eye socket collet, trachea cannula, auricle, hydrocephalus drainage tube, peritoneum dialysis catheter, band air bag Shunting conduit, catheter etc.) put into clinical application.Solid type medical grade silicon rubber can replace bone or cartilage, as tissue Filling or timbering material, therefore joint prosthesis, artificial tendon are can be made into repair the defect of extremities joint and tendon.Shaping material The multi-purpose material as the lopsided defect for repairing face, ear, nose etc..Film-type medical grade silicon rubber can use the alternative of stndon sheath Product.
More than, expect that one kind hernia made of silicon rubber repairs sticking patch, is applied in the treatment of mankind's hernia disease, it can be with The performances such as good biocompatibility possessed by silicon rubber are made full use of, are repaired one caused by sticking patch to solve current hernia A little adverse reactions.Currently, both at home and abroad there is not yet using report of the membrane structure tablet as hernia paster made of silicon rubber Road or similar patent.
Invention content
In order to solve above-mentioned technical problem in the prior art, the purpose of the present invention is to provide a kind of silicon rubber hernia reparations Sticking patch.
The object of the invention to solve the technical problems is realized using some technical solutions.It proposes according to the present invention A kind of silicon rubber hernia repair sticking patch, including mesh, elastic fibrous layer and body part, mesh be evenly distributed in body part, bullet Property fibrous layer be embedded in body part and in body part be in net distribution;Body part is made of silicon rubber.
It is a further object of the invention to provide a kind of silicon rubber hernias to repair sticking patch, and it is that can cut out that wherein hernia, which repairs sticking patch, It cultrates, body part is single layer silicon rubber film.
It is a further object of the invention to provide a kind of silicon rubber hernia repair sticking patch, wherein hernia repair sticking patch be in advance at Shape composite patch, composite patch include arch sticking patch and round hernia plug.
It is a further object of the invention to provide a kind of silicon rubber hernias to repair sticking patch, the wherein body part of arch sticking patch For arch single layer silicon rubber film, one end is provided with spermatic cord hole.
It is a further object of the invention to provide a kind of silicon rubber hernias to repair sticking patch, wherein the body part of round hernia plug For round balloon, it is also connected with a gas injection conduit in air bag circle centre position, duct ligation portion is provided on gas injection conduit.
It is a further object of the invention to provide a kind of silicon rubber hernias to repair sticking patch, wherein when in use, liquid/gas Body is injected by gas injection conduit in round balloon, and is ligatured with absorbable thread at duct ligation position.
It is a further object of the invention to provide a kind of silicon rubber hernias to repair sticking patch, and wherein liquid includes physiological saline Or sterile water for injection;Gas includes air or carbon dioxide.
It is a further object of the invention to provide a kind of silicon rubber hernias to repair sticking patch, wherein may be used also in the reparation sticking patch To include X-ray opaque substance.
It is a further object of the invention to provide a kind of silicon rubber hernias to repair sticking patch, and wherein X-ray opaque substance includes sulphur The polymer of sour barium.
Another purpose again of the present invention is, provides a kind of silicon rubber hernia and repairs application of the sticking patch in treating hernia, Middle hernia includes abdominal hernia, indirect inguinal hernia, umbilical hernia, femoral hernia, incisional hernia, pour hernie parastomiale, hiatal hernia.
The present invention has beneficial technique effect:
1, the use of silicon rubber is that hernia reparation sticking patch is prepared in raw material, which, which repairs sticking patch, to be had using silicon rubber Some pliabilitys and elasticity reduce pain and spermatic cord risk to reduce the stimulation to spermatic cord;Have additionally, due to silicon rubber good Biocompatibility, it is nonirritant to tissue, non-toxic, few without allergic reaction, body rejection, can obviously drop Low infection risk.
2, hernia of the invention repairs in sticking patch and is also inlaid with elastic fibrous layer, can improve the elasticity of sticking patch, increases sticking patch Tensile strength and elongation at break, overcome sticking patch suture after easily tearing, tension stress energy force difference defect.
3, hernia of the invention repairs sticking patch, and there is good physics characteristic, tensile strength to be more than 30MPa, extension at break Rate is more than 300%, and bursting strength is more than 30kPa.
4, its state of development is difficult to observe after being implanted into human body due to existing sticking patch, some are easy displacement or deformation, because This, hernia of the invention repair sticking patch in can also include X-ray opaque substance, can postoperative understanding sticking patch whether shift and deform, Intuitive medicine foundation is provided further to treat.
Description of the drawings
Fig. 1 is the stereogram according to the present invention for cutting shape hernia and repairing one embodiment of sticking patch;
Fig. 2 is the plan view shown in FIG. 1 for cutting shape hernia and repairing sticking patch;
Fig. 3 is the stereogram of one embodiment that arch hernia according to the present invention repairs sticking patch;
Fig. 4 is the plan view that arch hernia shown in Fig. 3 repairs sticking patch;
Fig. 5 is the stereogram of one embodiment of round hernia plug according to the present invention;
Fig. 6 is the plan view of round hernia plug shown in fig. 5.
Specific implementation mode
The invention will be further elaborated with reference to the accompanying drawings and examples, it should be appreciated that these embodiments are only used for It is bright the present invention rather than limit the scope of the invention.In addition, it should also be understood that, ability after reading the content taught by the present invention Field technique personnel can make the present invention various changes or modification, these equivalences equally fall within the application the appended claims institute The range of restriction.
Fig. 1 and Fig. 2 is the stereogram and plan view that cut shape hernia and repair sticking patch of the present invention.As shown, the hernia is repaiied Multiple sticking patch includes mesh 1, elastic fibrous layer 2 and body part 3, and mesh 1 is evenly distributed in body part 3, and elastic fibrous layer 2 is inlayed It is made of silicon rubber in net distribution, body part 3 in body part 3 and in body part 3.It is that can cut that such hernia, which repairs sticking patch, Shape, wherein body part 3 are single layer silicon rubber film, and thickness is between 0.3mm~1.5mm.Mesh 1 can have any desired Shape, including circle, ellipse, rectangle, square, it is therefore preferable to round.A diameter of 0.5mm~5mm of mesh 1, adjacent net The distance of center circle in hole grows into for tissue after repairing between 1mm~10mm, so that it is combined together with tissue at this; It can be used in art suturing or nail gun fixed.It is in net distribution that elastic fibrous layer 2, which is embedded in body part 3 and in body part 3, can To increase the tensile strength and elongation at break that hernia repairs sticking patch.It can also include to be not through x-ray that such hernia, which is repaired in sticking patch, The polymer of substance such as barium sulfate, does not react with surrounding tissue, can be used for the positioning of postoperative X line, understands whether sticking patch moves Position.
It is that can cut shape that such hernia, which repairs sticking patch, is performed the operation for all kinds of openings and laparoscopic hernia repair, only need to be in hernia defect Hernia defective region is fixed in tiling after fixation after area's tiling, child and adult inguinal hernia only need high ligation of hernial sac, It is more than hernia defect edge 5cm that patch size, which is subject to,.
Fig. 3 repairs the stereogram and plan view of sticking patch to the compound hernia of the preform silicon rubber for invention shown in fig. 6.The hernia It includes mesh 1, elastic fibrous layer 2 and body part 3 to repair sticking patch.Mesh 1 is evenly distributed in body part 3, and elastic fibrous layer 2 is inlayed It is made of silicon rubber in net distribution, body part 3 in body part 3 and in body part 3.It is one kind that such hernia, which repairs sticking patch, Compound sticking patch, including arch single layer silicon rubber film hernia repair sticking patch and round balloon hernia plug.Wherein, Fig. 3 and shown in Fig. 4 The stereogram and plan view of sticking patch are repaired for arch single layer silicon rubber film hernia;Fig. 5 and shown in fig. 6 for round balloon hernia plug Stereogram and plan view.
As shown in Figure 3 and Figure 4, it includes mesh 1,2 and of elastic fibrous layer which, which repairs sticking patch, Body part 3, body part 3 are arch single layer silicon rubber film, and thickness is between 0.3mm~1.5mm.Mesh 1 it is a diameter of 0.5mm~5mm, the distance of center circle of adjoining cells grow into for tissue after repairing between 1mm~10mm, make itself and this Place's tissue combines together;Suture or nail gun in art is can also be used for fix.Elastic fibrous layer 2 is embedded in body part 3 and in ontology It is in net distribution in portion 3, tensile strength and elongation at break that hernia repairs sticking patch can be increased.One end of body part 3 is additionally provided with Spermatic cord hole 4, the diameter in spermatic cord hole is between 0.5cm~1.0cm.As shown in Figure 5 and Figure 6, round balloon hernia plug include mesh 1, Elastic fibrous layer 2 and body part 3, body part 3 are round balloon 5, and the circle centre position of air bag 5 is also connected with a gas injection conduit 6, and gas injection is led Duct ligation portion 7 is provided on pipe 6.Gas injection conduit 6 is also to be made of silicon rubber, for liquid or gas to be injected air bag; Wherein liquid includes physiological saline or sterile water for injection, and gas includes air or carbon dioxide.May be used also in such composite patch It to include the polymer for the substance such as barium sulfate for being not through x-ray, does not react with surrounding tissue, it is fixed to can be used for postoperative X line Position, understands whether sticking patch shifts.
The compound sticking patch is mainly used for the opening repairing operation of indirect inguinal hernia, operation method and traditional tension-free hernia It performs the operation identical, hernia plug and plain film placement location are also essentially identical with traditional tension-free hernioplasty.In use, first at inner ring rear Blunt separation is suitble to the big lacunula of bladder-type hernia plug, by bladder-type hernia plug before inner ring is placed in peritonaeum, is injected from gas injection conduit 6 Gas (such as air or carbon dioxide) or the liquid (such as physiological saline or sterile water for injection) of sterilizing, make air bag 5 lead It moves before strutting merging peritonaeum, is then ligatured with absorbable thread at duct ligation position 7, while suturing fixed and wiping out extra gas injection Conduit 6;Can also air bag 5 flattening after by air bag 5 gas or liquid be discharged and meanwhile wipe out gas injection conduit 6.Then, will Arch single layer silicon rubber film hernia repairs sticking patch merging, and spermatic cord hole 4 is placed in spermatic cord rear, it is ridden and mistake from spermatic cord, root It sutures and fixes according to spermatic cord diameter, spermatic cord or so drawing is subject in the spermatic cord hole 4 after suture can freely activity.Other positions are fixed same Fixation is fixed or sutured to traditional tension-free hernioplasty, i.e. Kang Paite glue bonds.
It is that hernia reparation sticking patch is prepared in raw material that the hernia of the present invention, which repairs sticking patch using silicon rubber, which repairs sticking patch energy Pliability and elasticity possessed by silicon rubber are enough utilized, to reduce the stimulation to spermatic cord, reduces pain and spermatic cord risk;In addition by There is good biocompatibility in silicon rubber, it is nonirritant to tissue, non-toxic, anti-without allergic reaction, body rejection Should be few, infection risk can be substantially reduced.
The hernia of the present invention repairs in sticking patch and is also inlaid with elastic fibrous layer, can improve the elasticity of sticking patch, increase sticking patch Tensile strength and elongation at break are easily torn, the defect of tension stress energy force difference after overcoming sticking patch to suture.
The hernia of the present invention repairs sticking patch, and also there is good physics characteristic, tensile strength to be more than 30MPa, extension at break Rate is more than 300%, and bursting strength is more than 30kPa.
Its state of development is difficult to observe after being implanted into human body due to existing sticking patch, some are easy displacement or deformation, therefore, The present invention hernia repair sticking patch in can also include X-ray opaque substance, can postoperative understandings sticking patch whether shift and deform, be into The treatment of one step provides intuitive medicine foundation.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Any one skilled in the art is in the technical scope of present disclosure, the change or replacement that can be readily occurred in, It should all be included within the scope of the present invention.Therefore, protection scope of the present invention should be with the protection of claims Subject to range.

Claims (10)

1. a kind of silicon rubber hernia repairs sticking patch, it is characterised in that:It includes mesh, elastic fibrous layer and ontology that the hernia, which repairs sticking patch, Portion, the mesh are evenly distributed in the body part, and the elastic fibrous layer is embedded in the body part and at described It is in net distribution in body portion;The body part is made of silicon rubber.
2. hernia according to claim 1 repairs sticking patch, it is characterised in that:It is that can cut shape that the hernia, which repairs sticking patch, Body portion is single layer silicon rubber film.
3. hernia according to claim 1 repairs sticking patch, it is characterised in that:It is the compound benefit of preform that the hernia, which repairs sticking patch, Piece, the composite patch include arch sticking patch and round hernia plug.
4. hernia according to claim 3 repairs sticking patch, it is characterised in that:The body part of the arch sticking patch is arch Single layer silicon rubber film, one end are provided with spermatic cord hole.
5. hernia according to claim 3 repairs sticking patch, it is characterised in that:The body part of the circle hernia plug is circle Air bag is also connected with a gas injection conduit in the air bag circle centre position, duct ligation portion is provided on the gas injection conduit.
6. hernia according to claim 5 repairs sticking patch, it is characterised in that:In use, liquid/gas is passed through the gas injection Conduit injects in the round balloon, and is ligatured with absorbable thread in the duct ligation portion.
7. hernia according to claim 6 repairs sticking patch, it is characterised in that:The liquid includes physiological saline or aseptic injection Use water;The gas includes air or carbon dioxide.
8. repairing sticking patch according to claim 1-7 any one of them hernias, it is characterised in that:It can also be wrapped in the reparation sticking patch Substance containing X-ray opaque.
9. hernia according to claim 8 repairs sticking patch, it is characterised in that:The X-ray opaque substance includes the poly- of barium sulfate Close object.
10. the hernia according to claim 1-7, any one of 9 repairs application of the sticking patch in treating hernia, it is characterised in that: The hernia includes abdominal hernia, indirect inguinal hernia, umbilical hernia, femoral hernia, incisional hernia, pour hernie parastomiale, hiatal hernia.
CN201810082039.0A 2018-01-29 2018-01-29 A kind of silicon rubber hernia reparation sticking patch Pending CN108309503A (en)

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN113520663A (en) * 2021-08-20 2021-10-22 张铁民 Appliance for abdominal wall repair of inguinal hernia and embedded device for abdominal wall repair of inguinal hernia

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