CN102698318A - Biological-material complex patch - Google Patents
Biological-material complex patch Download PDFInfo
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- CN102698318A CN102698318A CN2012100527557A CN201210052755A CN102698318A CN 102698318 A CN102698318 A CN 102698318A CN 2012100527557 A CN2012100527557 A CN 2012100527557A CN 201210052755 A CN201210052755 A CN 201210052755A CN 102698318 A CN102698318 A CN 102698318A
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Abstract
The invention provides a novel biological-material complex patch which is of a laminated structure comprising a basic layer and an additional layer. The novel biological-material complex patch is characterized in that the basic layer is an patch made from an artificial synthetic material; the additional layer is a biological patch made from an extracellular matrix/acellular tissue matrix material, or a synthetic-material patch made from an artificial synthetic biological material or the artificial synthetic biological material and an artificial synthetic degradable material; and the basic layer and the additional layer are integrated through a surgical suture or a medical adhesive or other methods. The biological-material complex patch has the advantages of easiness for peripheral tissue growth and angiogenesis, adhesion prevention, degradability, good infection resistance and the like of the biological material and the advantages of easiness for tissue growth by of a big mesh, excellent infection resistance, difficulty for generating hydrops, non-degradability, high late mechanical strength and durability of the artificial-synthetic-material patch, adopts a simple production method, is more effective after being applied in clinic, and ensures recent and late relapse and infection rates to be lower.
Description
[technical field]
The present invention relates to a kind of novel biomaterial composite patch that all kinds of tissue defects are repaired that is applied to, be mainly used in the reparation abdominal-wall defect clinically.
[background technology]
Certain internal organs or tissue leave its normal anatomy position in the body, through congenital or the weak spot that form the day after tomorrow, damaged or another position of entering, space, promptly are called hernia (Hernia).Hernia all can occur at brain, breast, abdominal part, but betides abdominal part at most, comprises abdominal external hernia, internal abdominal hernia again, and abdominal external hernia is clinically to see at most.Abdominal external hernia be Intraabdominal internal organs or tissue together with parietal peritoneum, through stomach wall weak spot or hole, form to body surface is outstanding, Clinical types comprises hernia, incisional hernia at the bottom of inguinal hernia, femoral hernia, umbilical hernia, hernia linea alba, spigelian hernia, the basin, makes mouthful hernia etc.
The abdominal external hernia method for repairing and mending that adopts clinically at present is through open or laparoscopic surgery; Will be at the abdominal-wall defect position (being hernia ring, hernia door) also receive go back to the abdominal cavity to the outstanding internal organs of body surface; Again biocompatible materials (hernia sticking patch) is placed said abdominal-wall defect place, and it is passed through to sew up or other mode secure fixation.
(Polypropylene Mesh, Marlex PP) are formed by polypropylene fibre braiding the polypropylene sticking patch, are RF, are the patching materials of at present the most frequently used abdominal-wall defect.Have following obvious advantage: (1) is more soft, and more tolerance is crooked and folding; (2) size is cut out with the need; (3) stimulate the proliferation of fibrous tissue effect more obvious, mesh aperture is big, is more conducive to fibrous tissue growth and passes, and is prone to soaked into by connective tissue, can in early days and organize chimeric; (4) foreign body reaction is slight, and the patient does not have obvious foreign body and sense of discomfort, has very low relapse rate and complication rate; (5) more tolerance is infected, even granulation tissue still can be bred in the mesh of sticking patch in infected wound, does not cause that corrosion of net sheet or sinus tract form; (6) higher tensile strength is arranged; (7) do not receive the influence of water and most of chemical substances; (8) high temperature resistant, but scalding; (9) price is relatively cheap.Although it has been proved to be most popular implant in the current surgery implantation field, polypropylene net also exists some problems in application: at first, and when being used for stomach wall holostrome defect repairing; Sticking patch will be isolated with viscera tissue; If it directly contacts with internal organs and can cause more serious abdominal adhesions, digestive tract blocks, even possibly corrode intestinal wall; Cause intestinal fistula, increase the painful of patient even need second operation to take out sticking patch.
Expanded polytetrafluoroethylsealing anti sticking patch (Expanded Polytetrafluoroethylene patch, e-PTFE): compare more softness with the polypropylene sticking patch, be difficult for when contacting with abdominal viscera forming adhesion, caused inflammatory reaction is also the lightest; But expanded polytetrafluoroethylsealing anti sticking patch mesh is little, can allow antibacterial to pass through, and phagocyte can not be passed through; Organize also to be difficult for growing into, infect and pollution the wound that can not be used to pollute so it can not tolerate; Will take out in case infect sticking patch, otherwise wound is difficult to healing.
Present clinical composite patch commonly used; Like Ahmedabad composite patch (Bard Composix); This sticking patch is the two-sided composite patch of being processed by polypropylene and 2 kinds of materials of expanded polytetrafluoroethylsealing; But Bard Composix sticking patch lacks enough elasticity, and patient's postoperative possibly have discomforts such as stomach wall limited range of motion, foreign body sensation; A lot of fine mesh are arranged in order to drain on the expanded polytetrafluoroethylsealing layer, but owing to separate extensively in the art, blood oozing from the wound surface is also more, these mesh are prone to by obstructions such as sludged bloods, and hematocele, hydrops are difficult to avoid, and have also just increased the probability that infects; Other complication also exist, like film chamber syndrome between recurrence, intestinal adhesion, intestinal fistula, abdominal cavity etc.Slight infection can be through abundant drain, healing such as change dressings, and that serious infection is handled is more thorny, finally possibly take out or part is taken out sticking patch and caused operative failure.Expanded polytetrafluoroethylsealing material tolerance infection ability extreme difference, it possibly cause the delayed infection to receive home and abroad scholar attention day by day.
Taking off cell tissue substrate/extracellular matrix biological sticking patch is the trend of present clinical practice and the focus of research, and biomaterial has that the surrounding tissue of being easy to is grown into and new vessels generates anti; Degradable; And have good characteristics such as tolerance infection ability, possess greater advantage compared to other clinical synthetic materials commonly used, but be applied to the repairing or the reconstruction of huge abdominal-wall defect; Its undercapacity at a specified future date may limit its clinical practice; Especially to huge damaged reparation, this shortcoming is more outstanding, might cause the postoperative recurrence rate to raise.
[summary of the invention]
The objective of the invention is to solve the weak point of above-mentioned material; And make full use of its advantage separately: utilize biomaterial (taking off cell tissue substrate/extracellular matrix or synthetic biomaterial etc.) to have that the surrounding tissue of being easy to is grown into and new vessels generates; Anti; Degradable, and have good characteristics such as tolerance infection ability, possess greater advantage compared to other clinical synthetic materials commonly used; But be applied to the repairing or the reconstruction of huge abdominal-wall defect, its intensity at a specified future date does not obtain certainly; And the polypropylene sticking patch can cause that owing to it adhesion of abdominal cavity intestinal tube causes intestinal fistula then and forbids in Intraabdominal direct repairing; But because its big mesh; Be easy to tissue and grow into, therefore have good tolerance infection ability again, also be not easy to produce hydrops; And it is synthetic non-degradable material, has the mechanical strength at a specified future date that well continues.Polyester patches is the non-degradable material also, have the mechanical strength at a specified future date that well continues, and its crimp contraction is low.Synthetic sticking patch such as biological sticking patch and polypropylene or polyester is compound, make its mutual supplement with each other's advantages, process and both have good tolerance infection ability, have the novel anti biomaterial composite patch of enough mechanical strengths at a specified future date again.
The present invention provides a kind of novel biomaterial composite patch; Adopt synthetic sticking patch such as one deck polypropylene or polyester and one deck biological sticking patch (as taking off synthetic biomaterials such as cell tissue substrate/cell epimatrix material or synthetic biomaterial such as collagen protein etc. or itself and synthetic degradation material such as polylactic acid, polyglycolic acid, chitosan) formation; Synthetic sticking patch such as biological sticking patch and polypropylene or polyester are compound; Taken into account the advantage of synthetic material such as nondegradable polypropylene or polyester and degradable biological material, had complementary advantages, processed and both have good tolerance infection ability; But anti again; Also have enough NEW TYPE OF COMPOSITE sticking patch of mechanical strength at a specified future date, be mainly used in abdominal external hernia abdominal-wall defect or weak repairing, also can be used for Hernia hiatus and repair.
For realizing above-mentioned purpose; The present invention provides a kind of novel biomaterial composite patch; Said sticking patch is a laminated construction, and said laminated construction comprises basic unit and extra play, it is characterized in that said basic unit is the synthetic material sticking patch; Extra play is the synthetic material sticking patch of biomaterial sticking patch or synthetic biomaterial or itself and synthetic degradation material, with suture or medical glue or additive method one is processed by basic unit and extra play.
Composite patch of the present invention, wherein, said synthetic material sticking patch comprises nondegradable polypropylene sticking patch, polyester patches.
Composite patch of the present invention; Wherein, said biological sticking patch comprises that allogeneic takes off the synthetic material sticking patch that cell tissue substrate/cell epimatrix material biological sticking patch and heterogenous allosome take off cell tissue substrate/cell epimatrix material biological sticking patch or synthetic biomaterial or itself and comprise the synthetic degradation material of polylactic acid, polyglycolic acid, chitosan.
Composite patch of the present invention, wherein, said suture is that sub-thread does not absorb line or other stitching thread, or medical glue or other physics or chemical method composite biological material and synthetic material.
Composite patch of the present invention, wherein, said synthetic sticking patch thickness is 0.01mm-10mm.
Composite patch of the present invention, wherein, being shaped as circle, ellipse, rectangle, square, V-arrangement, hole shape, enclosing neck, cuff or oversleeve shape of said synthetic sticking patch, sphere or other are irregularly shaped.
Composite patch of the present invention, wherein, said allogeneic takes off cell tissue substrate/cell epimatrix material biological sticking patch and comprises corium acellular matrix, amniotic membrane, cerebral dura mater or other collagen stroma tissues.
Composite patch of the present invention, wherein, said heterogenous allosome take off cell tissue substrate/cell epimatrix material biological sticking patch comprise animal small intestinal submucosa (small intestinal submucosa, SIS), pericardium, peritoneum or other collagen stroma tissues.
Composite patch of the present invention, wherein, said synthetic biomaterial comprises collagen protein or itself and comprises the synthetic material sticking patch of the synthetic degradation material of polylactic acid, polyglycolic acid, chitosan.
Composite patch of the present invention, wherein, said biological sticking patch thickness is 0.01mm-10mm.
Composite patch of the present invention wherein, is saidly taken off being shaped as circle, ellipse, rectangle, square, V-arrangement, hole shape, enclosing neck, cuff or oversleeve shape of cell tissue substrate/extracellular matrix biological sticking patch, sphere or other are irregularly shaped.
Composite patch of the present invention, wherein, said biological sticking patch be shaped as circle, ellipse, rectangle, square or irregularly shaped.
Use the sub-thread nonabsorbable suture better, can reduce the chance of postoperative foreign body reaction and infection.
Composite patch can be for circle, ellipse, rectangle, square, V-arrangement, hole shape, enclose neck, cuff or oversleeve shape, sphere or other are irregularly shaped.
Novel biomaterial composite patch manufacture method is:
1. the netted fabric of synthetic materials such as polypropylene or polyester is adopted the synthetic material sticking patch such as polypropylene sticking patch or polyester patches that cut into reservation shape, size by the reservation shape cutter through ultrasound wave or hot melt, said hot melt instantaneous trip temperature is 120 ℃-150 ℃; Or adopt laser directly with the netted fabric cutting of synthetic materials such as polypropylene or polyester; Directly process the synthetic material sticking patch such as polypropylene sticking patch or polyester patches of reservation shape, size; Polypropylene sticking patch of processing or polyester patches etc. are carried out aseptic sterilization, packing, preservation more in a conventional manner, and be for use in the art;
In the art under the sterile working with direct cuttings of synthetic biomaterial such as allogeneic acellular matrix/extracellular matrix biological sticking patch or heterogenous allosome acellular matrix/extracellular matrix biological sticking patch or synthetic biomaterial such as collagen protein etc. or itself and synthetic degradation material such as polylactic acid, polyglycolic acid, chitosans, process the biological sticking patch of respective shapes, size;
3. in the art; The sterile working down will synthetic material sticking patch such as above-mentioned polypropylene sticking patch for preparing in advance or polyester patches with the stitching of biological sticking patch employing suture, medical adhesive dressing closes or other physics or chemical method are processed one, promptly processes the kind biomaterial composite patch of novel anti.
Biomaterial composite patch of the present invention is reasonable in design, simple in structure, easy to use.Constitute by synthetic material sticking patch such as polypropylene or polyester and biological sticking patch, utilize biomaterial to have that the surrounding tissue of being easy to is grown into and new vessels generates anti; Degradable, and have good characteristics and the big mesh of synthetic material sticking patch such as polypropylene or polyester such as tolerance infection ability; Be easy to tissue and grow into, have good tolerance infection ability, also be difficult for producing hydrops; And it is synthetic non-degradable material, has good mechanical strength at a specified future date.Synthetic material sticking patch such as biological sticking patch and polypropylene sticking patch or polyester patches is compound, make its mutual supplement with each other's advantages, process and both have good tolerance infection ability and biocompatibility, but anti has the NEW TYPE OF COMPOSITE sticking patch of enough mechanical strengths at a specified future date again.This novel biomaterial composite patch manufacture method is simple, and clinical application effect is better, and relapse rate and infection rate are low.
Description of drawings
Fig. 1 is the sketch map of biomaterial composite patch.
1 is biological sticking patch, and 2 is the synthetic material sticking patch.
[specific embodiment]
Technological means and the effect thereof taked for further setting forth the present invention are described in detail below in conjunction with enforcement case of the present invention.With reference to accompanying drawing 1, the biomaterial composite patch comprises 2 synusia, and 1 is biological sticking patch, and 2 is the polypropylene sticking patch, and biological sticking patch and polypropylene sticking patch adopt that suture is sewed up, medical adhesive dressing closes or other physics or chemical method are processed one.
Embodiment 1 is applied to clinical data statistics:
The present invention and clinical Bard Composix E/X sticking patch commonly used are compared research, be used for totally 30 of clinical patients, observation period 6～December.Method and result are following:
Matched group is got preformation pattern Bard Composix E/X sticking patch; The polypropylene material bed of material is towards the stomach wall side; Expanded polytetrafluoroethylsealing material layer internal organs in abdomen are fixed in damaged abdominal wall at sites with the sub-thread nonabsorbable suture with the sticking patch interrupted suture according to its standard operation method.
Test group is used the novel biomaterial composite patch; Polypropylene sticking patch layer is towards the stomach wall side; Biological sticking patch layer internal organs in abdomen; With the sub-thread nonabsorbable suture sticking patch interrupted suture is fixed in damaged abdominal wall at sites peritoneum, muscle, aponeurosis (aponeuroses) tissue on every side, the about 0.5-1.0cm in distance webs sheet edge during inserting needle, needle gage is 1.0-2.0cm.Notice during stitching that sub-thread does not absorb line and only passes polypropylene sticking patch layer, do not penetrate the biological sticking patch layer, the sticking patch after sutured is accomplished should open and flat nothing curls, no tension force, and surgical wound surface will carefully stop blooding, with the success of assurance operative repair.
The analysis of table 1 clinical data
Visible by table 1; Matched group adopts preformation pattern Bard Composix E/X sticking patch; Test group adopts biomaterial composite patch of the present invention; Biomaterial composite patch of the present invention is compared with preformation pattern Bard Composix E/X sticking patch, and postoperative recurrence rate and infection rate are lower, and clinical effectiveness is better.
Be pointed out that, the invention is not restricted to above-mentioned embodiment, any simple modification, equivalent variations and modification that any professional and technical personnel of being familiar with does the foregoing description based on technical scheme of the present invention all fall in protection scope of the present invention.
Claims (10)
1. novel biomaterial composite patch; Said sticking patch is a laminated construction; Said laminated construction comprises basic unit and extra play; It is characterized in that said basic unit is the synthetic material sticking patch, extra play is the synthetic material sticking patch of biomaterial sticking patch or synthetic biomaterial or itself and synthetic degradation material, with suture or medical glue or additive method one is processed by basic unit and extra play.
2. according to the said composite patch of claim 1, it is characterized in that said synthetic material sticking patch comprises nondegradable polypropylene sticking patch, polyester patches.
3. according to the said composite patch of claim 1, it is characterized in that said biological sticking patch comprises that allogeneic takes off the synthetic material sticking patch that cell tissue substrate/cell epimatrix material biological sticking patch and heterogenous allosome take off cell tissue substrate/cell epimatrix material biological sticking patch or synthetic biomaterial or itself and comprise the synthetic degradation material of polylactic acid, polyglycolic acid, chitosan.
4. according to the said composite patch of claim 1, it is characterized in that said suture is that sub-thread does not absorb line or other stitching thread.
5. according to the said composite patch of claim 2, it is characterized in that said synthetic sticking patch thickness is 0.01mm-10mm.
6. according to the said composite patch of claim 2, it is characterized in that being shaped as circle, ellipse, rectangle, square, V-arrangement, hole shape, enclosing neck, cuff or oversleeve shape of said synthetic sticking patch, sphere or other are irregularly shaped.
7. according to the said composite patch of claim 3, it is characterized in that said allogeneic takes off cell tissue substrate/cell epimatrix material biological sticking patch and comprises corium acellular matrix, amniotic membrane, cerebral dura mater or other collagen stroma tissues.
8. according to the said composite patch of claim 3, it is characterized in that said heterogenous allosome takes off small intestinal submucosa, pericardium, peritoneum or other collagen stroma tissues that cell tissue substrate/cell epimatrix material biological sticking patch comprises animal.
9. according to the said composite patch of claim 3, it is characterized in that said synthetic biomaterial comprises collagen protein or itself and comprises the synthetic material sticking patch of the synthetic degradation material of polylactic acid, polyglycolic acid, chitosan.
10. according to the said composite patch of claim 3, it is characterized in that saidly taking off being shaped as circle, ellipse, rectangle, square, V-arrangement, hole shape, enclosing neck, cuff or oversleeve shape of cell tissue substrate/extracellular matrix biological sticking patch, sphere or other are irregularly shaped.
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| CN2012100527557A CN102698318A (en) | 2012-03-02 | 2012-03-02 | Biological-material complex patch |
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| CN2012100527557A CN102698318A (en) | 2012-03-02 | 2012-03-02 | Biological-material complex patch |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769381A (en) * | 2015-05-26 | 2016-07-20 | 南通大学 | Biological patch for tissue damage restoration |
| CN105999419A (en) * | 2016-05-05 | 2016-10-12 | 烟台正海生物科技股份有限公司 | Bionical type absorbable dura mater patch and preparation method and application thereof |
| CN107050520A (en) * | 2017-03-03 | 2017-08-18 | 北京博辉瑞进生物科技有限公司 | Compound bio sticking patch and preparation method thereof |
| WO2017148255A1 (en) | 2016-03-01 | 2017-09-08 | 上海卓阮医疗科技有限公司 | Composite soft tissue repairing material for stabilizing repair region |
| CN107441557A (en) * | 2017-07-05 | 2017-12-08 | 北京大清生物技术股份有限公司 | A kind of functional organization's engineering scaffold material and preparation method thereof |
| CN107583110A (en) * | 2017-10-24 | 2018-01-16 | 杭州恩格生物医疗科技有限公司 | A kind of preparation method of the artificial esophagus with biological structure and function |
| CN107596447A (en) * | 2017-10-11 | 2018-01-19 | 广州新诚生物科技有限公司 | A kind of biological medicinal membrane with tissue repair function and preparation method thereof |
| CN107789092A (en) * | 2017-10-23 | 2018-03-13 | 上海利格泰生物科技有限公司 | The part repaired for shoulder sleeve can absorb composite patch and manufacture method |
| CN108066821A (en) * | 2016-11-10 | 2018-05-25 | 上海中医药大学附属曙光医院 | A kind of compound bio sticking patch for abdominal-wall defect reparation |
| CN108114320A (en) * | 2018-03-01 | 2018-06-05 | 北京迈迪顶峰医疗科技有限公司 | Tissue repair sticking patch, main body and preparation method |
| CN108852484A (en) * | 2018-03-23 | 2018-11-23 | 山东省千佛山医院 | Bone window protective device and preparation method after a kind of 3D printing skull decompressive craniectomy |
| CN109010927A (en) * | 2018-08-07 | 2018-12-18 | 中国人民解放军第二军医大学 | It is a kind of can slow releasing bioactivity factor de- cell bovine pericardium matrix preparation method |
| CN110464505A (en) * | 2019-07-12 | 2019-11-19 | 上海大学 | A kind of enhanced reticular structure stomach wall of elasticity repairs sticking patch and preparation method thereof |
| CN114028618A (en) * | 2021-10-25 | 2022-02-11 | 广东普洛宇飞生物科技有限公司 | Biological material based on amniotic membrane basement membrane and preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201350162Y (en) * | 2009-02-09 | 2009-11-25 | 黎洪棉 | Acellular allogeneic dermis matrix tissue sticking patch |
| CN101773689A (en) * | 2010-03-29 | 2010-07-14 | 苑国忠 | Surgical repairing patch |
| CN201664349U (en) * | 2009-06-30 | 2010-12-08 | 中国人民解放军第二军医大学 | Novel composite hernia and body wall repairing piece |
| CN102205151A (en) * | 2011-05-23 | 2011-10-05 | 中国医学科学院生物医学工程研究所 | Hernia patch solid-supported with antibiotic and preparation method |
| CN102217981A (en) * | 2011-05-16 | 2011-10-19 | 北京天助畅运医疗技术股份有限公司 | Multi-layer hernia repairing patch and preparation method thereof |
| CN102266585A (en) * | 2011-07-20 | 2011-12-07 | 中国人民解放军第三军医大学第一附属医院 | Biological composite patch for female pelvic floor and manufacturing method thereof |
-
2012
- 2012-03-02 CN CN2012100527557A patent/CN102698318A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201350162Y (en) * | 2009-02-09 | 2009-11-25 | 黎洪棉 | Acellular allogeneic dermis matrix tissue sticking patch |
| CN201664349U (en) * | 2009-06-30 | 2010-12-08 | 中国人民解放军第二军医大学 | Novel composite hernia and body wall repairing piece |
| CN101773689A (en) * | 2010-03-29 | 2010-07-14 | 苑国忠 | Surgical repairing patch |
| CN102217981A (en) * | 2011-05-16 | 2011-10-19 | 北京天助畅运医疗技术股份有限公司 | Multi-layer hernia repairing patch and preparation method thereof |
| CN102205151A (en) * | 2011-05-23 | 2011-10-05 | 中国医学科学院生物医学工程研究所 | Hernia patch solid-supported with antibiotic and preparation method |
| CN102266585A (en) * | 2011-07-20 | 2011-12-07 | 中国人民解放军第三军医大学第一附属医院 | Biological composite patch for female pelvic floor and manufacturing method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 张炜宇: "不同类型补片修补腹股沟疝的析因分析", 《中国组织工程研究与临床康复》 * |
| 陈刚等: "疝补片的外科应用", 《中国组织工程研究与临床康复》 * |
| 陈双: "疝修补材料的进展与展望", 《中国实用外科杂志》 * |
| 马思星等: "应用巴德复合补片修补腹壁切口疝的体会", 《贵阳医学院学报》 * |
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| CN105769381B (en) * | 2015-05-26 | 2018-04-17 | 南通大学 | A kind of biological sticking patch for tissue damage reparation |
| CN105769381A (en) * | 2015-05-26 | 2016-07-20 | 南通大学 | Biological patch for tissue damage restoration |
| US11058529B2 (en) | 2016-03-01 | 2021-07-13 | Shanghai Zhuoruan Medical Technologies Co., Ltd | Composite soft tissue repair material stable in repair area |
| WO2017148255A1 (en) | 2016-03-01 | 2017-09-08 | 上海卓阮医疗科技有限公司 | Composite soft tissue repairing material for stabilizing repair region |
| CN105999419A (en) * | 2016-05-05 | 2016-10-12 | 烟台正海生物科技股份有限公司 | Bionical type absorbable dura mater patch and preparation method and application thereof |
| CN105999419B (en) * | 2016-05-05 | 2019-04-30 | 烟台正海生物科技股份有限公司 | A kind of biomimetic type can absorb dural patch and the preparation method and application thereof |
| CN108066821A (en) * | 2016-11-10 | 2018-05-25 | 上海中医药大学附属曙光医院 | A kind of compound bio sticking patch for abdominal-wall defect reparation |
| CN107050520A (en) * | 2017-03-03 | 2017-08-18 | 北京博辉瑞进生物科技有限公司 | Compound bio sticking patch and preparation method thereof |
| CN107050520B (en) * | 2017-03-03 | 2020-05-05 | 北京博辉瑞进生物科技有限公司 | Composite biological patch and preparation method thereof |
| CN107441557A (en) * | 2017-07-05 | 2017-12-08 | 北京大清生物技术股份有限公司 | A kind of functional organization's engineering scaffold material and preparation method thereof |
| CN107596447A (en) * | 2017-10-11 | 2018-01-19 | 广州新诚生物科技有限公司 | A kind of biological medicinal membrane with tissue repair function and preparation method thereof |
| CN107789092A (en) * | 2017-10-23 | 2018-03-13 | 上海利格泰生物科技有限公司 | The part repaired for shoulder sleeve can absorb composite patch and manufacture method |
| CN107789092B (en) * | 2017-10-23 | 2023-07-18 | 上海利格泰生物科技股份有限公司 | Partially absorbable composite patch for rotator cuff repair and method of manufacture |
| CN107583110A (en) * | 2017-10-24 | 2018-01-16 | 杭州恩格生物医疗科技有限公司 | A kind of preparation method of the artificial esophagus with biological structure and function |
| CN108114320A (en) * | 2018-03-01 | 2018-06-05 | 北京迈迪顶峰医疗科技有限公司 | Tissue repair sticking patch, main body and preparation method |
| CN108852484B (en) * | 2018-03-23 | 2021-07-09 | 山东省千佛山医院 | 3D printing skull bone flap-removing decompression postoperative bone window protection device and preparation method |
| CN108852484A (en) * | 2018-03-23 | 2018-11-23 | 山东省千佛山医院 | Bone window protective device and preparation method after a kind of 3D printing skull decompressive craniectomy |
| CN109010927A (en) * | 2018-08-07 | 2018-12-18 | 中国人民解放军第二军医大学 | It is a kind of can slow releasing bioactivity factor de- cell bovine pericardium matrix preparation method |
| CN110464505A (en) * | 2019-07-12 | 2019-11-19 | 上海大学 | A kind of enhanced reticular structure stomach wall of elasticity repairs sticking patch and preparation method thereof |
| CN114028618A (en) * | 2021-10-25 | 2022-02-11 | 广东普洛宇飞生物科技有限公司 | Biological material based on amniotic membrane basement membrane and preparation method and application thereof |
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Application publication date: 20121003 |