CN206745664U - Compound bio sticking patch - Google Patents
Compound bio sticking patch Download PDFInfo
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- CN206745664U CN206745664U CN201621209211.7U CN201621209211U CN206745664U CN 206745664 U CN206745664 U CN 206745664U CN 201621209211 U CN201621209211 U CN 201621209211U CN 206745664 U CN206745664 U CN 206745664U
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- Prior art keywords
- sticking patch
- bletilla striata
- compound bio
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- biological
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Abstract
The utility model belongs to medical biomaterial technical field, discloses a kind of compound bio sticking patch, and the compound bio sticking patch includes biological sticking patch layer and overlay film in the bletilla striata fiber web layer of the side surface of biological sticking patch layer one；And the bletilla striata fiber web layer is electrostatic spinning nano level bletilla striata web.The utility model is by the way that nanometer bletilla striata fiber web layer is combined with traditional biological sticking patch overlay film, so as to get the anti-infection ability of compound bio sticking patch, wound repair ability effectively improves；Meanwhile the mechanical strength change after the compound bio sticking patch implanting to human body is consistently higher than required mechanical strength, can accelerate tissue reconstruction, helps solve biological sticking patch existing technologies bottleneck, is effectively improved the therapeutic effect of abdominal-wall defect reparation.
Description
Technical field
A kind of biomaterial for medical purpose is the utility model is related to, especially a kind of medical bio sticking patch.
Background technology
The research and development and application of biological sticking patch are current hernia and an important directions of stomach wall surgery research.Biological sticking patch refers to
Of the same race, xenogenesis tissue is derived from, completely retains extracellular matrix through taking off the various cells contained in cell processing removal tissue
Three-dimensional frame structure and the material for repairing human body soft tissue can be used for.It is divided into allogenic material such as according to tissue-derived
Corium acellular matrix, amnion, endocranium etc., heterogenous allosome material such as intestinal mucosa lower floor, the pericardium of the oxen and horses, ox peritonaeum
Deng.
After biological sticking patch implantation, progressively degraded with the biological sticking patch that grows into of host tissue, final biological sticking patch quilt completely
Host tissue replaces.Therefore, biological sticking patch repair mechanism is " endogenous tissue regeneration ", and it induces stem cell to enter biology and mended
Piece, extracellular matrix secretion substitute the implant of degraded.Biological sticking patch has certain tolerance infection ability, and this has benefited from its energy
Realize that early stage local quick revascularization, phagocyte early stage enter, make bacterial biof iotalm be difficult to be formed, therefore biological sticking patch can use
In the surface of a wound with pollution or latent infection.
But current biological sticking patch is remained in some problems urgently to be resolved hurrily.Sticking patch drops in itself after biological sticking patch implanting to human body
Rebuild in a organized way again while solution, if the synthesis force diagram of both is consistently higher than in the mechanical strength change to implant
The mechanical strength of implant, then sticking patch repairing can accomplish the end in view；Conversely, repairing will fail.To find out its cause, without outer
Following two reasons：1st, biological sticking patch degraded is too fast, and tissue reconstruction is relatively slow, causes the synthesis force diagram of both
It is less than stomach wall mechanical strength in some stage.Though the 2, biological sticking patch degraded is slow, and tissue reconstruction relative deficiency, finally still results in and repair
Mend failure.
Utility model content
The purpose of this utility model is to provide a kind of compound bio sticking patch suitable for hernia and stomach wall surgical repair, effectively
Improve the therapeutic effect of clinical abdominal-wall defect reparation.
In order to solve the above technical problems, the utility model provides a kind of compound bio sticking patch, the compound bio sticking patch bag
Layer containing biological sticking patch and overlay film are in the bletilla striata fiber web layer of the side surface of biological sticking patch layer one.China traditional Chinese medicine bletilla striata is in clinic
On to promote wound healing special effect, tissue reconstruction can be accelerated.In recent years, further definitely demonstrate,proved by modern medicine study
Real, the active ingredient of the bletilla striata has the function of improving macrophage in wound tissue, promote vascular endothelial cell adhesion growth, can
Significantly improve the multiplication capacity of cell, while the function of also antibacterial hemostasis.The utility model by by bletilla striata fiber web layer with
Traditional biological sticking patch overlay film combines, so as to get anti-infection ability, wound repair energy of the compound bio sticking patch after implanting
Power effectively improves.In addition, the mechanical strength change after compound bio sticking patch implanting to human body provided by the utility model is begun
It is higher than required mechanical strength eventually, tissue reconstruction can be accelerated, helps solve the existing bottleneck of biological sticking patch, further improve stomach wall
The therapeutic effect of defect repair.
Preferably, in compound bio sticking patch provided by the utility model, overlay film is in the bletilla striata of traditional biological patch faces
Fiber web layer is nanoscale bletilla striata web；Further, the fibre diameter of nanoscale bletilla striata web is 100~500 nanometers,
The thickness of the nanoscale bletilla striata web is 0.2~1 millimeter.Nano level bletilla striata fiber web layer is made due to the minute diameter of material
It has larger specific surface area, has greatly advantage in medicament slow release application, is advantageous to preferably play bletilla striata fibrous layer
To improvement result of the traditional biological sticking patch on repairing effect.
Preferably, in compound bio sticking patch provided by the utility model, nanoscale bletilla striata web is received for electrostatic spinning
Meter level bletilla striata web.Electrostatic spinning, also referred to as Electrospun, it is that one kind utilizes polymer solution or the melt shape under forceful electric power field action
The technique for carrying out spinning processing into injection stream.Obtained fibre diameter can reach nanometer scale.It can also introduce wherein inorganic
Particle, active component, medicine etc. improve the performance of material, by structure, the control of composition, reach promotion guide tissue regeneration
The effect of function, the functionalized nano electrospinning wire material that electrospinning makes, in organizational project, wound dressing, enzyme immobilizatio
It is widely used with biomedical aspects such as medicine (gene) carriers.Compound bio provided by the utility model is mended
Piece, the nanoscale bletilla striata web prepared with electrostatic spinning technique is used to be combined with traditional biological sticking patch overlay film, further optimization
The medical performance of compound bio sticking patch.
Further, in compound bio sticking patch provided by the utility model, biological sticking patch layer is the routine of market purchase
Biological sticking patch.Can be specifically allogenic material type sticking patch or heterogenous allosome material type sticking patch.Wherein, allogenic material type
Sticking patch can be corium acellular matrix source sticking patch, amnion-derived sticking patch or endocranium source sticking patch etc.；Heterogenous allosome material
Type sticking patch is intestinal mucosa lower floor source sticking patch, bovine pericardium source sticking patch, horse pericardium source sticking patch or ox peritonaeum source sticking patch
Deng.Such as can be purchase from Cook (Cook), great achievement of radically reforming, Guan Haodeng companies biological sticking patch.
Brief description of the drawings
Fig. 1 is the structural representation of the compound bio sticking patch of the utility model first embodiment.
Embodiment
It is new to this practicality below in conjunction with accompanying drawing to make the purpose of this utility model, technical scheme and advantage clearer
Each embodiment of type is explained in detail.It is however, it will be understood by those skilled in the art that each in the utility model
In embodiment, in order that reader more fully understands the application and proposes many ins and outs.But even if without these skills
Art details and many variations based on following embodiment and modification, it can also realize that each claim of the application is required and protect
The technical scheme of shield.
Compound bio sticking patch involved by first embodiment of the present utility model include biological sticking patch layer 1 and overlay film in
The bletilla striata fiber web layer 2 of the side surface of biological sticking patch layer 1 one.
The thickness of above-mentioned bletilla striata fiber web layer 2 is 0.2 millimeter, and the fibre diameter of nanoscale bletilla striata fiber is 100 nanometers,
And the nanoscale bletilla striata web is prepared using electrostatic spinning.Above-mentioned biological sticking patch layer 1 is purchased from Cook (Cook) company,
Trade name hundred must be filled in, and be trees-Osima jacoti, Osima excavata acellular matrix biological sticking patch.
Compound bio sticking patch involved by second embodiment of the present utility model also includes biological sticking patch layer and overlay film
Nanoscale bletilla striata fiber web layer in the side surface of biological sticking patch layer one.
The thickness of nanoscale bletilla striata fiber web layer in present embodiment is 1 millimeter, and the fiber of nanoscale bletilla striata fiber is straight
Footpath is 300 nanometers, and the nanoscale bletilla striata web is prepared using electrostatic spinning.Biological sticking patch layer in present embodiment
Purchased from great achievement company of radically reforming.
Compound bio sticking patch involved by 3rd embodiment of the present utility model also includes biological sticking patch layer and overlay film
Nanoscale bletilla striata fiber web layer in the side surface of biological sticking patch layer one.
The thickness of nanoscale bletilla striata fiber web layer in present embodiment is 0.6 millimeter, the fiber of nanoscale bletilla striata fiber
A diameter of 500 nanometers, and the nanoscale bletilla striata web is prepared using electrostatic spinning.Biological sticking patch in present embodiment
Layer is purchased from Guan Hao companies.
It will be understood by those skilled in the art that the respective embodiments described above are to realize specific implementation of the present utility model
Example, and in actual applications, can to it, various changes can be made in the form and details, without departing from spirit of the present utility model
And scope.
Claims (6)
1. a kind of compound bio sticking patch, it is characterised in that comprising biological sticking patch layer (1) and overlay film in the biological sticking patch layer
The bletilla striata fiber web layer (2) of (1) one side surface,
The bletilla striata fiber web layer (2) is nanoscale bletilla striata web, and the nanoscale bletilla striata web is received for electrostatic spinning
Meter level bletilla striata web.
2. compound bio sticking patch according to claim 1, it is characterised in that the fiber of the nanoscale bletilla striata web is straight
Footpath is 100~500 nanometers.
3. compound bio sticking patch according to claim 1, it is characterised in that the thickness of the nanoscale bletilla striata web is
0.2~1 millimeter.
4. the compound bio sticking patch according to any one of claims 1 to 3, it is characterised in that the biological sticking patch layer (1) is
Allogenic material type sticking patch or heterogenous allosome material type sticking patch.
5. compound bio sticking patch according to claim 4, it is characterised in that the allogenic material type sticking patch is corium
Acellular matrix source sticking patch, amnion-derived sticking patch or endocranium source sticking patch.
6. compound bio sticking patch according to claim 4, it is characterised in that the heterogenous allosome material type sticking patch is that pig is small
Intestinal mucosa lower floor source sticking patch, bovine pericardium source sticking patch, horse pericardium source sticking patch or ox peritonaeum source sticking patch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621209211.7U CN206745664U (en) | 2016-11-10 | 2016-11-10 | Compound bio sticking patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621209211.7U CN206745664U (en) | 2016-11-10 | 2016-11-10 | Compound bio sticking patch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206745664U true CN206745664U (en) | 2017-12-15 |
Family
ID=60606887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621209211.7U Expired - Fee Related CN206745664U (en) | 2016-11-10 | 2016-11-10 | Compound bio sticking patch |
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| Country | Link |
|---|---|
| CN (1) | CN206745664U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108309503A (en) * | 2018-01-29 | 2018-07-24 | 张士丰 | A kind of silicon rubber hernia reparation sticking patch |
-
2016
- 2016-11-10 CN CN201621209211.7U patent/CN206745664U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108309503A (en) * | 2018-01-29 | 2018-07-24 | 张士丰 | A kind of silicon rubber hernia reparation sticking patch |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171215 Termination date: 20191110 |
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| CF01 | Termination of patent right due to non-payment of annual fee |