CN102920528A - Hollowed-out membrane used as hernia patch and preparation method thereof - Google Patents
Hollowed-out membrane used as hernia patch and preparation method thereof Download PDFInfo
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- CN102920528A CN102920528A CN2012104022509A CN201210402250A CN102920528A CN 102920528 A CN102920528 A CN 102920528A CN 2012104022509 A CN2012104022509 A CN 2012104022509A CN 201210402250 A CN201210402250 A CN 201210402250A CN 102920528 A CN102920528 A CN 102920528A
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- thin film
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
Abstract
The invention discloses a hollowed-out membrane used as a hernia patch and a preparation method thereof. The hollowed-out membrane used as the hernia patch is a high-polymer membrane with holes, and the high-polymer membrane with the holes is used as the hernia patch; and the thickness of the high-polymer membrane is 0.05 to 1.0 millimeter. The preparation method comprises the following steps of: (1) preparing a high-polymer material into a primary membrane by a melting casting method; (2) performing two-way stretching on the primary membrane; (3) punching the holes in the surface of the membrane by a machine carving method; and (4) flattening and performing heat setting to obtain the hollowed-out membrane used as the hernia patch. The hollowed-out membrane has high mechanical property and biocompatibility. And the method for preparing the single-layer hollowed-out membrane for the hernia patch is simple and is suitable for industrial production.
Description
Technical field
The invention belongs to the application of bio-medical material, relate to a kind of hollow type diaphragm that is used as hernia paster and preparation method thereof.
Background technology
In the daily life, the disappearance of tissue and organ, breakage or nonfunction are very common, and health of people and life have been consisted of serious threat.For a long time constantly exploration of people and research material and biotechnology its objective is the relevant issues that solve in the medical science, ensure human health, are prevention, diagnosis, treatment and the rehabilitation service of disease.
Hernia, namely tissue or an organ part have been left original position, enter another position by people's body space, damaged or weak part.Hernia is that a kind of multiple diseases, especially old man and child morbidity rate are higher.Because hernia can cause various diseases, and health of people and life have been consisted of serious threat.Hernia can have the danger of incarceration at any time as not treating.As occur pain, quality hard, rub and be difficult for also receiving and with stomachache, abdominal distention, the performances such as nausea and vomiting gradually occurring, the time can cause intestinal tube ischemic necrosis threat to life more for a long time.General adult suffers from afterwards voluntarily rehabilitation of hernia, must treat by external means.For hernia, different Therapeutic Method is arranged.Wherein traditional Therapeutic Method comprises: 1. hernia truss; 2. herbal treatment; 3. injection sealing; 4. surgical operation etc.For the adult, generally adopt operative treatment.Traditional operation is that breakage is directly sewed on thick line, and this method weak point is that tension force stitching, sharp ache, recovery are slow.
The treating hernia that appears as of hernia paster provides new thinking.Kugel[Kugel, Hernia mesh Patch with seal stiffener, U.S.Pat.No.6,290,708] designed the hernia paster of double-deck inert material web frame, ground floor is the hernia repair material, and the second layer is reinforcement material, the effect that hernia paster can not fold when playing operation.John Allen Pacey[John Allen Pacey, Percutaneous cannula delvery system for hernia Patch, US2002/0103494 A1] polytetrafluoroethylplastic plastic that utilizes nickel chromium triangle to strengthen, prepared hernia paster.Gregory A Spitz[Gregory A Spitz, Methods and apParatus for the rePair of hernias, US2005/0159777A1] designed a kind of hernia repair film, by hernical sac is put into preperitoneal space, after the hernical sac venting, just can open and flatly come, play the effect of hernia repair.Mainly use at present U.S. surgery company (Tyc Surgipro Plug Mate), the product of Johnson Co. and the Perifix Plug of U.S.'s Ahmedabad (Bard) company on the market, China's Mainland.This several prods all is obtained by polypropylene, and by charges and one piece of plain film composition of a taper, the modus operandi of employing is the filled type Inguinal Hernia Herniorrhaphy.
In recent years, domestic research worker also is studied aspect hernia paster.Chen Nanliang [Chen Nanliang etc., polypropylene warp-knitted hernia paster and preparation method thereof: CN1775188] has prepared hernia paster with the medical grade polypropylene monofilament by braiding, product stability and good uniformity, and quality meets or exceeds same kind of products at abroad.The people such as Shen Xinyuan [Shen Xinyuan etc., a kind of reticulated for medical hernia paster; CN101518478] prepared hernia paster with the medical grade polycaprolactone by braiding, product biological stability, good biocompatibility, polycaprolactone monofilament rigidity is relatively large, and the product mechanical property is better.Because polycaprolactone degradable does not need the taking-up of again performing the operation.The people such as Sheng Yuying [Sheng Yuying etc., hernia paster, CN2863013] have invented the polypropylene hernia paster in a kind of Permanent implantation human body.It mainly is comprised of outer layer net plug, plain film net sheet, and feature is that two four leaf petal-shaped net sheets are set in the outer layer net plug, and two four leaf petal-shaped net sheets are enclosed within and form bullet in the outer layer net plug.This sticking patch is compact, rationally; Can cut randomly according to the size of hernia, patient compliance is strong, and operating time shortens greatly, and patient's misery is little, and recovery time is short, and can prevent the hernia recurrence.The shortcoming of this product is complex structure, and preparation technology is loaded down with trivial details.
At present, hernia paster both domestic and external all is the network structure that is formed by fibrage, has comparatively soft characteristics.Its shortcoming is, after according to the wound surface size hernia paster being cut out when doctor's clinical operation, the edge part is fluffed easily, and the end of a thread is at random, brings some inconvenience to stitching, has also affected to a certain extent suture strength.In addition, netted hernia paster also exists some problems in application: repair if carry out large-area abdominal-wall defect, as deal with improperly, the cicatrix contraction in later stage can cause the distortion of net sheet, its irregular surface may stimulate and damage surrounding tissue, causes to infect the skin tunnel of dieing.
Summary of the invention
The objective of the invention is that the easily fluffing of back edge part, the end of a thread are at random, the cicatrix contraction can cause the problems such as hernia paster distortion for cutting out of existing of prior art hernia paster, a kind of hollow type diaphragm that is used as hernia paster and preparation method thereof is provided, be a kind of hernia paster with single thin film engraved structure and preparation method thereof, this hernia paster has preferably mechanical property and biocompatibility.When carrying out the hernia repair operation, cut out sticking patch by required size first, then to sew up, the hole on the sticking patch can be used as sewing hole.The hernia paster preparation method of this single thin film engraved structure is simple, is suitable for suitability for industrialized production.Hernia paster of the present invention adopts thin film Carving Machining technique, obtains hollowed membrane, this engraved structure guaranteed sticking patch light and handy, thoroughly liquid, soft in, can also arbitrarily be cut out and do not produced burr the end of a thread.By the thickness degree of regulation and control thin film, can regulate thin film pliability and with the docile and obedient property of tissue.
A kind of hollow type diaphragm that is used as hernia paster of the present invention for being with pertusate macromolecule membrane, describedly is with pertusate macromolecule membrane to be used as hernia paster; Described macromolecule membrane thickness is 0.05～1.0mm; The material of described macromolecule membrane is polyethylene (PE), polypropylene (PP), Kynoar (PVDF) or polyethylene terephthalate (PET).Above-mentioned material is medical material commonly used, and a large amount of medical practices have proved its reliability, so the present invention selects these materials to prepare hernia paster.
As preferred technical scheme:
Aforesaid a kind of hollow type diaphragm that is used as hernia paster, described hole be distributed as even distribution, hole ratio (hole accounts for the ratio of the gross area) is 40～90%.Hole in the hernia paster mainly is used for breathing freely, conveying body fluids, and for guaranteeing the intensity of hernia paster, hole should evenly distribute; Hole ratio also need not be excessive or too small, and the too small body fluid that is unfavorable for is carried the excessive intensity that then affects hernia paster.
Aforesaid a kind of hollow type diaphragm that is used as hernia paster, described hole is circular hole, rectangular opening, regular polygon hole or elliptical aperture.The concrete shape of hole is little to the Effect on Mechanical Properties of hernia paster, major requirement good uniformity and being evenly distributed.
Aforesaid a kind of hollow type diaphragm that is used as hernia paster, the diameter of described circular hole is 2～10mm, the distance of center circle of adjacent circular holes is between 5～22mm; The length of described rectangular opening is 1～20mm, and length-width-ratio is 1～5, and the rib between the adjacent rectangle hole is wide to be 0.2～5mm; The limit number in described just polygon hole is 3～8, and the length of side is 0.2～5mm, and the distance between the regular polygon center is 2～20mm; Described elliptical aperture ratio of semi-minor axis length is 1～5, and minor axis length is 1～5mm.
Aforesaid a kind of hollow type diaphragm that is used as hernia paster, described macromolecule membrane are that the material of described macromolecule membrane is made nascent thin film by the thin film of 1～6 times of biaxial tension by the melting casting method.The hot strength of thin film is greater than 20MPa, and elongation at break is 10～50%.
The present invention also provides a kind of preparation method that is used as the hollow type diaphragm of hernia paster, may further comprise the steps:
(1) material of described macromolecule membrane is made nascent thin film by the melting casting method;
(2) nascent thin film is carried out biaxial tension, to increase thin film mechanical performance;
(3) adopt the machine engraving process to get hole at film surface;
(4) then carry out smooth thermal finalization and process, namely get the described hollow type diaphragm that is used as hernia paster.
Aforesaid a kind of preparation method that is used as the hollow type diaphragm of hernia paster, the melting curtain coating film-forming method in the described step (1), for polyethylene: melting masking temperature is 150～250 ℃; For polypropylene: melting masking temperature is 220～280 ℃; For Kynoar: melting masking temperature is 200～280 ℃; For polyethylene terephthalate: melting masking temperature is 285～300 ℃.
Aforesaid a kind of preparation method that is used as the hollow type diaphragm of hernia paster, described biaxial tension multiple is for being respectively 1～6 times.
Aforesaid a kind of preparation method that is used as the hollow type diaphragm of hernia paster, described smooth thermal finalization is processed: for polyethylene, heat setting temperature is 50～90 ℃; For polypropylene, heat setting temperature is 90～140 ℃; For Kynoar, heat setting temperature is 90～150 ℃; For polyethylene terephthalate, heat setting temperature is 160～220 ℃.
Aforesaid a kind of preparation method that is used as the hollow type diaphragm of hernia paster, the time that described smooth thermal finalization is processed is 30～60 minutes.
Beneficial effect
(1) moulding of hernia paster all is the fabric that is formed by fibrage at present, and great majority are wovens that PP fibrage forms, and price comparison is cheap usually; Minority is the two-layer fabric that PP fiber and the fiber interweavings such as PVDF, PGA form, and the performance on its fabric two sides is not quite similar, so price is also higher.The processes route of this hernia paster assembling-disassembling is longer, and desired process equipment investment is larger.Hollow type hernia paster of the present invention, processing technique is terse, and technological process is short, and floor space is little, and equipment investment is few.
(2) the present invention adopts computer to carry out Graphics Design, instructs the engraving machine automatic operation, and is workable, and style changes convenient.
(3) hernia paster of the present invention can be adjusted by the thickness of adjusting diaphragm the flexibility of hernia paster, in addition because hernia paster of the present invention is smooth membranaceous, so relatively good with the docile and obedient property of histoorgan.
(4) this hollow type hernia paster preparation method is simple, is suitable for suitability for industrialized production.
Description of drawings
Fig. 1 is a kind of circular hole hollow type diaphragm sketch map that is used as hernia paster of the present invention
Fig. 2 is a kind of rectangular opening hollow type diaphragm sketch map that is used as hernia paster of the present invention
The specific embodiment
Below in conjunction with the specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used for explanation the present invention and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims limited range equally.
Embodiment 1
(1) getting polyethylene (PE) is raw material, makes thin film by the melting casting method under 250 ℃ of temperature.
(2) the nascent thin film of PE is carried out biaxial tension, draw ratio is 6 times, and final thickness is 0.2mm.
(3) adopt the machine engraving process that thin film is punched, the Graphics Design in hole is rectangle, and width is 2mm, and length-width ratio is 2, and the rib between the hole is wide to be 0.8mm, as shown in Figure 2.
(4) the smooth thermal finalization of under 90 ℃ of temperature the thin film after the hollow out being carried out 30 minutes is processed, and namely gets the hollow type hernia paster, and hot strength is 30MPa, and elongation at break is 10%.Can suitably cut out according to actual needs during clinical practice.
Embodiment 2
(1) getting polyethylene (PE) is raw material, makes thin film by the melting casting method under 150 ℃ of temperature.
(2) the nascent thin film of PE is carried out biaxial tension, draw ratio is 1 times, and final thickness is 1.0mm.
(3) adopt the machine engraving process that thin film is punched, the Graphics Design in hole is rectangle, and width is 1mm, and length-width ratio is 5, and the rib between the hole is wide to be 0.2mm.
(4) the smooth thermal finalization of under 50 ℃ of temperature the thin film after the hollow out being carried out 60 minutes is processed, and namely gets the hollow type hernia paster, and hot strength is 21MPa, and elongation at break is 50%.Can suitably cut out according to actual needs during clinical practice.
Embodiment 3
(1) getting polyethylene (PE) is raw material, makes thin film by the melting casting method under 200 ℃ of temperature.
(2) the nascent thin film of PE is carried out biaxial tension, draw ratio is 3 times, and final thickness is 0.4mm.
(3) adopt the machine engraving process that thin film is punched, the Graphics Design in hole is rectangle, and length is 20mm, and length-width ratio is 4, and the rib between the hole is wide to be 5mm.
(4) the smooth thermal finalization of under 70 ℃ of temperature the thin film after the hollow out being carried out 40 minutes is processed, and namely gets the hollow type hernia paster, and hot strength is 26MPa, and elongation at break is 20%.Can suitably cut out according to actual needs during clinical practice.
Embodiment 4
(1) getting polypropylene (PP) is raw material, makes thin film by the melting casting method under 280 ℃ of temperature.
(2) the nascent thin film of PP is carried out biaxial tension, draw ratio is 4 times, and final thickness is 0.3mm.
(3) adopt the machine engraving process that thin film is punched, the Graphics Design in hole is equilateral triangle, and the length of side is 2.5mm, tri-angle-holed being uniformly distributed on the thin film, and the distance between the triangle center is 4mm.
(4) the smooth thermal finalization of under 90 ℃ of temperature the thin film after the hollow out being carried out 60 minutes is processed, and namely gets the hollow type hernia paster, and hot strength is 28MPa, and elongation at break is 32%.Can suitably cut out according to actual needs during clinical practice.
Embodiment 5
(1) getting polypropylene (PP) is raw material, makes thin film by the melting casting method under 220 ℃ of temperature.
(2) the nascent thin film of PP is carried out biaxial tension, draw ratio is 6 times, and final thickness is 0.05mm.
(3) adopt the machine engraving process that thin film is punched, the Graphics Design in hole is equilateral triangle, and the length of side is 0.2mm, tri-angle-holed being uniformly distributed on the thin film, and the distance between the triangle center is 2mm.
(4) the smooth thermal finalization of under 140 ℃ of temperature the thin film after the hollow out being carried out 30 minutes is processed, and namely gets the hollow type hernia paster, and hot strength is 22MPa, and elongation at break is 40%.Can suitably cut out according to actual needs during clinical practice.
Embodiment 6
(1) getting polypropylene (PP) is raw material, makes thin film by the melting casting method under 250 ℃ of temperature.
(2) the nascent thin film of PP is carried out biaxial tension, draw ratio is 2 times, and final thickness is 1mm.
(3) adopt the machine engraving process that thin film is punched, the Graphics Design in hole is equilateral triangle, and the length of side is 5mm, tri-angle-holed being uniformly distributed on the thin film, and the distance between the triangle center is 20mm.
(4) the smooth thermal finalization of under 110 ℃ of temperature the thin film after the hollow out being carried out 50 minutes is processed, and namely gets the hollow type hernia paster, and hot strength is 27MPa, and elongation at break is 34%.Can suitably cut out according to actual needs during clinical practice.
Embodiment 7
(1) getting Kynoar (PVDF) is raw material, makes thin film by the melting casting method under 200 ℃ of temperature.
(2) the nascent thin film of PVDF is carried out biaxial tension, draw ratio is 6 times, and final thickness is 0.25mm.
(3) adopt the machine engraving process that thin film is punched, the Graphics Design in hole is regular hexagon, and the length of side is 2mm, and the regular hexagon hole is uniformly distributed on the thin film, and the distance between the regular hexagon center is 4mm.
(4) the smooth thermal finalization of under 90 ℃ of temperature the thin film after the hollow out being carried out 45 minutes is processed, and namely gets the hollow type hernia paster, and hot strength is 23MPa, and elongation at break is 15%.Can suitably cut out according to actual needs during clinical practice.
Embodiment 8
(1) getting Kynoar (PVDF) is raw material, makes thin film by the melting casting method under 280 ℃ of temperature.
(2) the nascent thin film of PVDF is carried out biaxial tension, draw ratio is 3 times, and final thickness is 0.76mm.
(3) adopt the machine engraving process that thin film is punched, the Graphics Design in hole is octagon, and the length of side is 0.2mm, and the octagon hole is uniformly distributed on the thin film, and the distance between the octagon center is 2mm.
(4) the smooth thermal finalization of under 150 ℃ of temperature the thin film after the hollow out being carried out 30 minutes is processed, and namely gets the hollow type hernia paster, and hot strength is 26MPa, and elongation at break is 22%.Can suitably cut out according to actual needs during clinical practice.
Embodiment 9
(1) getting Kynoar (PVDF) is raw material, makes thin film by the melting casting method under 240 ℃ of temperature.
(2) the nascent thin film of PVDF is carried out biaxial tension, draw ratio is 4 times, and final thickness is 0.8mm.
(3) adopt the machine engraving process that thin film is punched, the Graphics Design in hole is regular pentagon, and the length of side is 5mm, and the regular pentagon hole is uniformly distributed on the thin film, and the distance between the regular pentagon center is 20mm.
(4) the smooth thermal finalization of under 100 ℃ of temperature the thin film after the hollow out being carried out 60 minutes is processed, and namely gets the hollow type hernia paster, and hot strength is 27MPa, and elongation at break is 19%.Can suitably cut out according to actual needs during clinical practice.
Embodiment 10
(1) gets polyethylene terephthalate (PET) and be raw material, under 300 ℃ of temperature, make thin film by the melting casting method.
(2) the nascent thin film of PET is carried out biaxial tension, draw ratio is 6 times, and final thickness is 0.15mm.
(3) adopt the machine engraving process that thin film is punched, the Graphics Design in hole is circular, and diameter is 3mm, and circular port is uniformly distributed on the thin film, and the distance between the center of circle is 3.2mm, as shown in Figure 1.
(4) the smooth thermal finalization of under 160 ℃ of temperature the thin film after the hollow out being carried out 60 minutes is processed, and namely gets the hollow type hernia paster, and hot strength is 27MPa, and elongation at break is 19%.Can suitably cut out according to actual needs during clinical practice.
Embodiment 11
(1) gets polyethylene terephthalate (PET) and be raw material, under 285 ℃ of temperature, make thin film by the melting casting method.
(2) the nascent thin film of PET is carried out biaxial tension, draw ratio is 1 times, and final thickness is 1.0mm.
(3) adopt the machine engraving process that thin film is punched, the Graphics Design in hole is circular, and diameter is 10mm, and circular port is uniformly distributed on the thin film, and the distance between the center of circle is 22mm.
(4) the smooth thermal finalization of under 220 ℃ of temperature the thin film after the hollow out being carried out 32 minutes is processed, and namely gets the hollow type hernia paster, and hot strength is 29MPa, and elongation at break is 25%.Can suitably cut out according to actual needs during clinical practice.
Embodiment 12
(1) gets polyethylene terephthalate (PET) and be raw material, under 300 ℃ of temperature, make thin film by the melting casting method.
(2) the nascent thin film of PET is carried out biaxial tension, draw ratio is 3 times, and final thickness is 0.4mm.
(3) adopt the machine engraving process that thin film is punched, the Graphics Design in hole is elliptical aperture, and ratio of semi-minor axis length is 1, and minor axis length is 1mm, adjacent ellipses span 0.2mm.
(4) the smooth thermal finalization of under 180 ℃ of temperature the thin film after the hollow out being carried out 44 minutes is processed, and namely gets the hollow type hernia paster, and hot strength is 24MPa, and elongation at break is 18%.Can suitably cut out according to actual needs during clinical practice.
Embodiment 12
(1) gets polyethylene terephthalate (PET) and be raw material, under 295 ℃ of temperature, make thin film by the melting casting method.
(2) the nascent thin film of PET is carried out biaxial tension, draw ratio is 4 times, and final thickness is 0.6mm.
(3) adopt the machine engraving process that thin film is punched, the Graphics Design in hole is elliptical aperture, and ratio of semi-minor axis length is 5, and minor axis length is 5mm, adjacent ellipses span 3mm.
(4) the smooth thermal finalization of under 190 ℃ of temperature the thin film after the hollow out being carried out 40 minutes is processed, and namely gets the hollow type hernia paster, and hot strength is 26MPa, and elongation at break is 22%.Can suitably cut out according to actual needs during clinical practice.
Claims (10)
1. hollow type diaphragm that is used as hernia paster is characterized in that: the described hollow type diaphragm that is used as hernia paster is for being with pertusate macromolecule membrane, describedly is with pertusate macromolecule membrane to be used as hernia paster; Described macromolecule membrane thickness is 0.05～1.0mm; The material of described macromolecule membrane is polyethylene, polypropylene, Kynoar or polyethylene terephthalate.
2. a kind of hollow type diaphragm that is used as hernia paster according to claim 1 is characterized in that, described hole be distributed as even distribution, hole ratio also is that hole area and the ratio that accounts for the gross area are 40～90%.
3. a kind of hollow type diaphragm that is used as hernia paster according to claim 1 and 2 is characterized in that, described hole is circular hole, rectangular opening, regular polygon hole or elliptical aperture.
4. a kind of hollow type diaphragm that is used as hernia paster according to claim 3 is characterized in that the diameter of described circular hole is 2～10mm, and the distance of center circle of adjacent circular holes is between 5～22mm; The length of described rectangular opening is 1～20mm, and length-width-ratio is 1～5, and the rib between the adjacent rectangle hole is wide to be 0.2～5mm; The limit number in described just polygon hole is 3～8, and the length of side is 0.2～5mm, and the distance between the regular polygon center is 2～20mm; Described elliptical aperture ratio of semi-minor axis length is 1～5, and minor axis length is 1～5mm, and the adjacent ellipses span is 0.2mm at least.
5. a kind of hollow type diaphragm that is used as hernia paster according to claim 1, it is characterized in that, described macromolecule membrane is that the material of described macromolecule membrane is made nascent thin film by the thin film of 1～6 times of biaxial tension by the melting casting method, the hot strength of thin film is greater than 20MPa, and elongation at break is 10～50%.
6. such as the described a kind of preparation method that is used as the hollow type diaphragm of hernia paster of claim 1～5 any one, it is characterized in that may further comprise the steps:
(1) material of described macromolecule membrane is made nascent thin film by the melting casting method;
(2) nascent thin film is carried out biaxial tension, to increase thin film mechanical performance;
(3) adopt the machine engraving process to get hole at film surface;
(4) then carry out smooth thermal finalization and process, namely get the described hollow type diaphragm that is used as hernia paster.
7. a kind of preparation method that is used as the hollow type diaphragm of hernia paster as claimed in claim 6 is characterized in that described step
(1) the melting curtain coating film-forming method in, for polyethylene: melting masking temperature is 150～250 ℃; For polypropylene: melting masking temperature is 220～280 ℃; For Kynoar: melting masking temperature is 200～280 ℃; For polyethylene terephthalate: melting masking temperature is 285～300 ℃.
8. a kind of preparation method that is used as the hollow type diaphragm of hernia paster as claimed in claim 6 is characterized in that described biaxial tension multiple is respectively 1～6 times.
9. a kind of preparation method that is used as the hollow type diaphragm of hernia paster as claimed in claim 6 is characterized in that, described smooth thermal finalization is processed: for polyethylene, heat setting temperature is 50～90 ℃; For polypropylene, heat setting temperature is 90～140 ℃; For Kynoar, heat setting temperature is 90～150 ℃; For polyethylene terephthalate, heat setting temperature is 160～220 ℃.
10. a kind of preparation method that is used as the hollow type diaphragm of hernia paster as claimed in claim 6 is characterized in that, the time that described smooth thermal finalization is processed is 30～60 minutes.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106901866A (en) * | 2015-12-22 | 2017-06-30 | 上海典范医疗科技有限公司 | Compound dural patch for preventing adhesion and preparation method thereof |
| CN108309503A (en) * | 2018-01-29 | 2018-07-24 | 张士丰 | A kind of silicon rubber hernia reparation sticking patch |
| CN111803710A (en) * | 2016-12-28 | 2020-10-23 | 广州迈普再生医学科技股份有限公司 | Composite tissue repair patch prepared by tape casting process and preparation method thereof |
| CN113081379A (en) * | 2021-04-01 | 2021-07-09 | 云南大学 | Three-dimensional developable hernia repair composite patch and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040034374A1 (en) * | 2002-08-16 | 2004-02-19 | Tutogen Medical Gmbh | Implant |
| CN101623516A (en) * | 2009-08-10 | 2010-01-13 | 浙江普洛医药科技有限公司 | In-situ fiber-forming strengthened degradable medical elastic composite material and preparation method thereof |
| CN102028560A (en) * | 2010-11-14 | 2011-04-27 | 薛运章 | Protomorphic sticking patch for groin herniorrhaphy and manufacture method thereof |
| CN102217981A (en) * | 2011-05-16 | 2011-10-19 | 北京天助畅运医疗技术股份有限公司 | Multi-layer hernia repairing patch and preparation method thereof |
| CN102316823A (en) * | 2009-02-11 | 2012-01-11 | 新加坡南洋理工大学 | Multi-layered surgical prosthesis |
| CN202821713U (en) * | 2012-10-19 | 2013-03-27 | 东华大学 | Hollow membrane for colic patch |
-
2012
- 2012-10-19 CN CN2012104022509A patent/CN102920528A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040034374A1 (en) * | 2002-08-16 | 2004-02-19 | Tutogen Medical Gmbh | Implant |
| CN102316823A (en) * | 2009-02-11 | 2012-01-11 | 新加坡南洋理工大学 | Multi-layered surgical prosthesis |
| CN101623516A (en) * | 2009-08-10 | 2010-01-13 | 浙江普洛医药科技有限公司 | In-situ fiber-forming strengthened degradable medical elastic composite material and preparation method thereof |
| CN102028560A (en) * | 2010-11-14 | 2011-04-27 | 薛运章 | Protomorphic sticking patch for groin herniorrhaphy and manufacture method thereof |
| CN102217981A (en) * | 2011-05-16 | 2011-10-19 | 北京天助畅运医疗技术股份有限公司 | Multi-layer hernia repairing patch and preparation method thereof |
| CN202821713U (en) * | 2012-10-19 | 2013-03-27 | 东华大学 | Hollow membrane for colic patch |
Non-Patent Citations (2)
| Title |
|---|
| 周祥兴: "塑料薄膜常用生产方法", 《中国包装报》, 18 October 2002 (2002-10-18), pages 003 * |
| 陈英: "聚丙烯流延薄膜的生产技术和进展", 《塑料包装》, vol. 14, no. 4, 30 November 2004 (2004-11-30) * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106901866A (en) * | 2015-12-22 | 2017-06-30 | 上海典范医疗科技有限公司 | Compound dural patch for preventing adhesion and preparation method thereof |
| CN111803710A (en) * | 2016-12-28 | 2020-10-23 | 广州迈普再生医学科技股份有限公司 | Composite tissue repair patch prepared by tape casting process and preparation method thereof |
| CN111803710B (en) * | 2016-12-28 | 2022-04-19 | 广州迈普再生医学科技股份有限公司 | Composite tissue repair patch prepared by tape casting process and preparation method thereof |
| CN108309503A (en) * | 2018-01-29 | 2018-07-24 | 张士丰 | A kind of silicon rubber hernia reparation sticking patch |
| CN113081379A (en) * | 2021-04-01 | 2021-07-09 | 云南大学 | Three-dimensional developable hernia repair composite patch and preparation method thereof |
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