CN108853603A - Biodegradable medical kirsite sticking patch of one kind and its preparation method and application - Google Patents

Biodegradable medical kirsite sticking patch of one kind and its preparation method and application Download PDF

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Publication number
CN108853603A
CN108853603A CN201710327212.4A CN201710327212A CN108853603A CN 108853603 A CN108853603 A CN 108853603A CN 201710327212 A CN201710327212 A CN 201710327212A CN 108853603 A CN108853603 A CN 108853603A
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kirsite
sticking patch
biodegradable medical
silk material
preparation
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CN108853603B (en
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黄华
袁广银
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Shanghai Jiaotong University
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Shanghai Jiaotong University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/042—Iron or iron alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/082—Inorganic materials
    • A61L31/086—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/04—Materials or treatment for tissue regeneration for mammary reconstruction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

The present invention provides a kind of biodegradable medical kirsite sticking patch and its preparation method and application, belong to the technical field of medical supplies.Its main feature is that being woven into porous reticular structure by the kirsite silk material of round, ellipse or rectangle (flat strip shaped) using section, the reticular structure is equipped with absorbable coating.The sticking patch can also press absorbable film layer by surface, different band overlay film sticking patch is prepared into, applied to different clinical diseases.Sticking patch prepared by the present invention has low in cost, the processing is simple, low thickness, the advantages that high-flexibility and good biocompatibility, and higher mechanical property can be maintained in certain time by being implanted into after human body, degradable after patient wound's healing simultaneously to be absorbed by the human body, noresidue in vivo mitigates the sense of discomfort and adverse reaction in patient's healing later period.

Description

Biodegradable medical kirsite sticking patch of one kind and its preparation method and application
Technical field
The present invention relates to medical instruments field, in particular to a kind of biodegradable medical kirsite sticking patch and its preparation Method and purposes belong to the technical field of medical supplies.
Background technique
Sticking patch has extensive clinical application in disease treatment and plastic surgery.On the one hand, many disease treatments It needs using tissue repairing patch.Such as：The reparation of the positions such as the wall of the chest, stomach wall bulk tissue defect is very difficult, clinical operation Sticking patch is commonly used during treatment.Secondly, hernia refers to that internal organs leave original position, by the weak spot or defect of human body, Hole enters another position, is also required to use sticking patch during operative treatment.Again, female pelvic floor dysfunctional disease with Stress incontinence, pelvic organ prolapse and chronic pelvic pain etc. are a kind of gynecological disease of chief complaint, numerous studies Show to realize that Pelvic pain syndrome improves the safety of operation compared with traditional Hysterectomy mode using basin bottom sticking patch Property, and improve postoperative patient quality of life.Furthermore hypophysoma is encephalic kinds of tumor, and encephalic disease incidence occupies third position, accounts for about cranium The 10% of interior tumour is a kind of from anterior pituitary and rear page and the cytogenetic tumour of craniopharyhgeal canal epithelial rest, now clinical Using most scope intranasals-transsphenoidal pituitary tumor resection, the approach of operation is to enter sphenoid sinus through nostril, opens saddle bottom, excision Tumour will cause bone defect destruction, used operative repair method is usually that sticking patch is filled up in bone during opening saddle bottom Defect opening.On the other hand, with the development of society, improvement of living standard, plastic operation is also more more and more universal, wherein cream Room orthopedic is exactly a kind of most commonly seen one of plastic operation, and most commonly seen in mammaplasty is breast enlargement, breast Sagging epithesis, breast prosthetic and breast reconstruction；In these mammaplasties, it usually needs be implanted into breast prosthesis Pectoralis major, often there is human body to the rejection of foreign matter in patient after surgery, there is also the complication such as prostheses migration, sagging, Huge pain is caused to patient.
The more artificial mesh material of application mainly includes polypropylene net (such as Marlex, Prolene), polytetrafluoro at present Ethylene sticking patch (PTFE, Gore-Tex sticking patch), polyester mesh sheet (such as Dacron, Mersilene) dacron patch.Currently, above-mentioned Sticking patch be mostly high molecular material and cannot degrade or Partial digestion.These traditional artificial materials, which implant, will increase wound The chance of mouthfeel dye, postoperative infection is its maximum complication, and must second operation taking-up after infection.Therefore exploitation has more The patching material of good biocompatibility remains an extremely meaningful job.
Zinc is necessary nutrient in human body, if children, zinc-deficiency in growth and development stage will lead to depauperation. When lacking serious, it will cause " nanism " and intellectual development bad.In addition, zinc is the key that brain cell growth, zinc-deficiency can shadow The function of ringing brain, reduces brain cell.Zinc-deficiency also results in sense of taste decline, anorexia, partial eclipse even different food occurs.Day recommends intake Amount is 15mg.Therefore, zinc and its alloy have good biocompatibility.In addition, the kirsite mechanical property that is specifically suitable for and Corrosion degradation performance, and have the advantages that low-melting to melting preparation and easy to process.Therefore kirsite can trust Be applied to clinical implantation material.
In the patent of Publication No. CN 106361476A, disclose a kind of Weaving type degradable magnesium alloy airway stent and Preparation method, the magnesium alloy airway stent use the magnesium alloy silk material of diameter 0.1mm~0.5mm is integrated weaved to form, magnesium Alloy airway stent surface mesh is quadrangle, and single screening area is 2mm2~10mm2, the diameter 0.1mm~0.5mm's Magnesium alloy silk material is monofilament or mariages or multifibres in braiding.But magnesium alloy road bracket obtained in the patent is mainly used in gas The treatment of tract disease, the shape after braiding are tubular, and the research of the invention finds that, not all magnesium alloy may serve to It is applied after being woven；It is uneven to be easy to appear degradation during degradation for magnesium alloy silk material in that patent, and causes to produce Product early stage fails because of local corrosion degradation.In addition, since its corrosion degradation rate is very fast when magnesium alloy is implanted directly into application, It cannot obtain a relatively good therapeutic effect.
Summary of the invention
For the defects in the prior art, the purpose of the present invention is to provide a kind of biodegradable medical kirsites to mend Piece and preparation method thereof, the kirsite sticking patch are able to satisfy different reparation requirements, can repair deficiency and the absorption that can gradually degrade.
The purpose of the present invention is achieved through the following technical solutions：
In a first aspect, the present invention provides a kind of biodegradable medical kirsite sticking patch, the sticking patch is by kirsite The porous reticular structure that silk material is woven into, the reticular structure are equipped with absorbable coating, the kirsite silk material it is transversal Face is round, ellipse or rectangle (flat strip shaped).Round silk material prepares most simple process, but relative to oval or rectangular For shape silk material, the thickness of the sticking patch after braiding is bigger.
Preferably, the kirsite is binary kirsite, ternary kirsite or quaternary kirsite, and specially Zn-Cu zinc closes Gold, Zn-Li kirsite, Zn-Mg kirsite, Zn-Fe kirsite, Zn-Cu-Fe kirsite, Zn-Cu-Mg kirsite or Zn-Cu- Li-Fe kirsite.There is above-mentioned alloy good mechanical property and biology performance all not to contain toxic element simultaneously, wherein Zn-Li kirsite alloy shows relatively good mechanical property, and the alloy containing Mg shows the biology performance compared, and contains Cu Alloy have certain antibacterial effect.It can choose the material with different characteristics according to the difference that clinical application is diseased region Expect the sticking patch of preparation.
Preferably, the silk material braiding can diversification.On the one hand it can be carried out with flexible choice using monofilament or multifibres Different cross modals and different angles additionally can be used to be woven, two kinds in attached Fig. 1 and 2 present invention in braiding Than more typical monofilament weaving manner.
Preferably, unit made of the kirsite silk material is monofilament or is woven as multifilament.I.e. kirsite is used in braiding Silk material can be the rope that monofilament is also possible to multifilament braiding.
Preferably, the sectional area of the kirsite silk material is 0.0028-0.3mm2。
Preferably, the sticking patch with a thickness of 0.1-1mm, the area of single mesh is 0.1-10mm2.Braiding silk material Thickness difference determines the thickness for finally knitting out the product come, and the meticulous one side of silk is difficult to, and furthermore silk material is woven into The mechanical property of sticking patch also can be poor, however silk material is excessively thick, although mechanical property is relatively good, flexibility is poor, drops simultaneously The required time that solution absorbs can be too long.The weaving manner of silk material determines the area of a mesh, the too small one side wave of area More silk materials are taken, on the other hand the transmission of inconvenient all kinds of nutriments.Mesh area is excessive, then the mechanical property of product It is too low, it is not enough to reach as intensity requirement needed for sticking patch.
Preferably, the preparation method of the absorbable coating can refer to patent CN 201510351233.0, CN 201310306991.1 or CN 201510564506.X.Wherein, absorbable coating is also referred to as biodegradable coating.
Preferably, absorbable film layer is covered on the sticking patch.
It is highly preferred that the absorbable film layer is that poly- third friendship-caprolactone copolymer can absorb film layer or polycaprolactone-phosphorus Sour tricalcium can absorb film layer.The sticking patch can also press poly- third friendship-caprolactone copolymer or polycaprolactone-in clinical application After the absorbable film layer such as tricalcium phosphate as overlay film sticking patch come using.
Second aspect, the present invention provide a kind of preparation method of biodegradable medical kirsite sticking patch, the preparation Method includes the following steps：
S1, Zinc alloy bar is machined out turning, obtains cylindrical wire squeeze blank；
S2, cylindrical wire squeeze is subjected to hot extrusion with blank, obtains silk material blank；
S3, drawing, rolling deformation are carried out to silk material blank and assists obtaining kirsite monofilament to be heat-treated.
S4, kirsite monofilament or the unit as made of more kirsite monofilament braidings are woven into networking on volume machine, through electricity Solution polishing, cleaning, coating treatment, drying, sterilization treatment obtain the kirsite sticking patch.
Preferably, in step S2, the diameter of the silk material blank is
Preferably, in step S2, the process conditions of the hot extrusion are：Temperature 50 C is squeezed to 300 DEG C, extrusion ratio 9 to 60。
Preferably, in step S3, the process conditions of the drawing are：Room temperature drawing and deflection is no more than per pass 20%；The process conditions of the rolling deformation are：Room temperature rolling and per pass deflection are no more than 20%；The work of the heat treatment Skill condition is：100 DEG C to 300 DEG C are annealed 30 minutes to 2 hours.
Preferably, in step S4, to the kirsite sticking patch further progress coating processing.The kirsite sticking patch is worked as When as overlay film sticking patch, it is also necessary to further carry out coating processing.
The third aspect, the present invention provide the biodegradable medical kirsite sticking patch of one kind as hernia prosthesis, basin Chamber internal organs prolapse surgery, wall of the chest prosthesis, Pituitaryadenoma is performed the operation or the purposes of plastic surgery operations tissue repairing patch. The porous network structure that the kirsite silk material is woven into can be applied to after the coating processing of coating treatment and selectivity Hernia reparation, pelvic organ prolapse operation, wall of the chest reparation, Pituitaryadenoma operation etc., can also be applied to breast, male sex organ etc. Plastic surgery operations.
Sticking patch prepared by the present invention have it is low in cost, the processing is simple, low thickness, high-flexibility and good biocompatibility etc. Advantage, and be implanted into after human body and can maintain higher mechanical property in certain time, while is degradable after patient wound's healing It is absorbed by the human body, in vivo noresidue, mitigates the sense of discomfort and adverse reaction in patient's healing later period.
Compared with prior art, the present invention has following beneficial effect：
(1) sticking patch can be degradable, and metabolism is gradually absorbed by the human body during disease recovery, and sticking patch is implanted into initial stage With good supporting role, the later period, the degradable autologous tissue that is absorbed as after the completion of tissue repair replaced, and can avoid tradition The possible long term complication of material.
(2) by adjusting the size of silk material, appearance and weaving method, different types of kirsite sticking patch can be obtained, With different intensity and degradation soak time, the different patient's condition can be suitble to.
(3) be directed to different illnesss, the degradation speed and biocompatibility of sticking patch can be by coating treatment and overlay film at Reason is further regulated and controled and is improved, to meet the requirement of different parts and organ-tissue reparation.
(4) kirsite fusing point is low, and it is simple and low in cost that preparation process is processed in melting.
(5) product woven in this patent be used as sticking patch purposes, while weave after product be it is planar, can also basis Treatment when demand carry out arbitrary shape cutting.In addition, the research of the invention finds that, not all kirsite is ok For applying after being woven and sticking patch, clearly propose in this patent using Zn-Cu kirsite, Zn-Li kirsite, Zn-Mg This several class of kirsite, Zn-Fe kirsite, Zn-Cu-Fe kirsite, Zn-Cu-Mg kirsite or Zn-Cu-Li-Fe kirsite are preferred Alloy carry out the preparation of braiding silk material, be primarily used to guarantee also to guarantee that silk material is dropping while the mechanical property of product It uniformly degrades during solution, to prevent product early stage from failing because of local corrosion degradation.In addition, the corrosion degradation of kirsite Rate is more moderate, when clinical application relatively good its active time of control.
(6) this patent also proposed braiding after reticular structure application when need to prepare one layer of biodegradable coating, coating Preparation on the one hand effectively improve the biocompatibility of alloy, on the other hand can also be different according to desired different additions Ingredient realize different biological special efficacys, such as antibacterial, promote to repair etc., so that degradable kirsite sticking patch described in this patent Clinically have a good application prospect.Patent of the sticking patch described in this patent relative to Publication No. CN106361476A Described in degradable magnesium alloy airway stent, on the one hand improve its corrosion degradation performance, while improving the biology of product Compatibility performance, and the disease type of application for the treatment of is entirely different, the range of application is wider.
Detailed description of the invention
Upon reading the detailed description of non-limiting embodiments with reference to the following drawings, other feature of the invention, Objects and advantages will become more apparent upon：
Fig. 1 is the schematic diagram of the interlacing mode one of kirsite sticking patch prepared by the present invention；
Fig. 2 is the schematic diagram of the interlacing mode two of kirsite sticking patch prepared by the present invention.
Specific embodiment
The present invention is described in detail combined with specific embodiments below.Following embodiment will be helpful to the technology of this field Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill of this field For personnel, without departing from the inventive concept of the premise, several changes and improvements can also be made.These belong to the present invention Protection scope.
The cylindrical wire squeeze blank of turning certain altitude；By cylindrical wire squeeze blank, the heat under certain temperature is carried out It squeezes, obtaining diameter isSilk material blank；Multi pass drawing, rolling deformation are carried out to silk material blank and assisted at heat Reason, can obtain the filament material of different string diameters.
The interlacing mode of the biodegradable medical kirsite sticking patch prepared in the present invention can with as shown in Figure 1, It can also be as shown in Figure 2.
Embodiment 1
The present embodiment is related to biodegradable medical kirsite sticking patch of one kind and preparation method thereof, and specific preparation method is such as Under：
1) be the section 0.07mm using the diameter that the above method is prepared it is circular Zn-Cu alloy threadlet material, is compiling Networking is woven on machine, can be cut randomly.
2) through electrobrightening, cleaning.
3) biodegradable coating is handled.
4) stand-by after dry, packaging, sterilization treatment.
Final products with a thickness of 0.1mm, single mesh area is 0.1mm2。
Embodiment 2
The present embodiment is related to biodegradable medical kirsite sticking patch of one kind and preparation method thereof, and specific preparation method is such as Under：
1) long axis that section is ellipse is prepared using the above method is the Zn-Cu- that 0.09mm short axle is 0.07mm Fe alloy threadlet material, weaves networking on volume machine, can cut randomly.
2) through electrobrightening, cleaning.
3) biodegradable coating is handled.
4) stand-by after dry, packaging, sterilization treatment.
Final products with a thickness of 0.2mm, single mesh area is 4mm2。
Embodiment 3
The present embodiment is related to biodegradable medical kirsite sticking patch of one kind and preparation method thereof, and specific preparation method is such as Under：
It 1) is rectangle using the section that the above method is prepared, long side 0.4mm, width is the Zn- of the flat strip shaped of 0.2mm Fe based alloy filament material, weaves networking on volume machine, can cut randomly.
2) through electrobrightening, cleaning.
3) biodegradable coating is handled, and is then pressed one layer of PLCL and is can absorb film layer (poly- third friendship-caprolactone copolymer).
4) it is used as ventral hernia repair mesh sheet after dry, packaging, sterilization treatment.
Final products with a thickness of 0.6mm, the single mesh area of wire side is 10mm2。
Embodiment 4
The present embodiment is related to biodegradable medical kirsite sticking patch of one kind and preparation method thereof, and specific preparation method is such as Under：
It 1) be the interface 0.1mm using 3 diameters that the above method is prepared is circular Zn-Cu-Mg alloy threadlet material, Cord is woven on volume machine.
2) it is woven to net on volume machine using cord, can cut randomly.
2) through electrobrightening, cleaning.
3) biodegradable coating is handled, and is then pressed one layer of PCL-TCP and is can absorb film layer (polycaprolactone-tricalcium phosphate).
4) it is used as Pituitaryadenoma operation sticking patch after dry, packaging, sterilization treatment.
Final products with a thickness of 1.0mm, the single mesh area of wire side is 7mm2。
Implementation result：Biodegradable medical kirsite sticking patch made from embodiment 1-4 is subjected to zoopery, effect Well.Sticking patch for different parts need to have different mechanical performance and degradation speed.Can according to the actual situation to sticking patch into Row regulation.The intensity of silk material used can fluctuate within the scope of 150MPa~450MPa, the elongation percentage of kirsite silk material 20%~ In 150% range.The porous reticular structure being woven into, degradation cycle is 8 months~36 months controllable after coating treatment.
Specific embodiments of the present invention are described above.It is to be appreciated that the invention is not limited to above-mentioned Particular implementation, those skilled in the art can make a variety of changes or modify within the scope of the claims, this not shadow Ring substantive content of the invention.In the absence of conflict, the feature in embodiments herein and embodiment can any phase Mutually combination.

Claims (10)

1. a kind of biodegradable medical kirsite sticking patch, which is characterized in that the sticking patch is woven by kirsite silk material Porous reticular structure, the reticular structure is equipped with absorbable coating, and the cross section of the kirsite silk material is round, ellipse Round or rectangle.
2. biodegradable medical kirsite sticking patch according to claim 1, which is characterized in that the kirsite is two First kirsite, ternary kirsite or quaternary kirsite, specially Zn-Cu kirsite, Zn-Li kirsite, Zn-Mg kirsite, Zn- Fe kirsite, Zn-Cu-Fe kirsite, Zn-Cu-Mg kirsite or Zn-Cu-Li-Fe kirsite.
3. biodegradable medical kirsite sticking patch according to claim 1, which is characterized in that the kirsite silk material Unit made of being woven for monofilament or as multifilament.
4. biodegradable medical kirsite sticking patch according to claim 1 or 3, which is characterized in that the kirsite The sectional area of silk material is 0.0028-0.3mm2。
5. biodegradable medical kirsite sticking patch according to claim 1, which is characterized in that the thickness of the sticking patch For 0.1-1mm, the area of single mesh is 0.1-10mm2。
6. biodegradable medical kirsite sticking patch according to claim 1, which is characterized in that covered on the sticking patch There is absorbable film layer.
7. biodegradable medical kirsite sticking patch according to claim 6, which is characterized in that the absorbable film layer Film layer is can absorb for poly- third friendship-caprolactone copolymer or polycaprolactone-tricalcium phosphate can absorb film layer.
8. a kind of preparation method of biodegradable medical kirsite sticking patch according to claim 1, which is characterized in that The preparation method includes the following steps：
S1, turning is machined out to Zinc alloy bar, obtains cylindrical wire squeeze blank；
S2, cylindrical wire squeeze is subjected to hot extrusion with blank, obtains silk material blank；
S3, drawing, rolling deformation are carried out to silk material blank and assists obtaining kirsite monofilament to be heat-treated.
S4, kirsite monofilament or the unit as made of more kirsite monofilament braidings are woven into networking on volume machine, is thrown through electrolysis Light, cleaning, coating treatment, drying, sterilization treatment obtain the kirsite sticking patch.
9. the preparation method of biodegradable medical kirsite sticking patch according to claim 8, which is characterized in that step In S4, to the kirsite sticking patch further progress coating processing.
10. a kind of biodegradable medical kirsite sticking patch according to claim 1 is as hernia prosthesis, pelvic cavity Internal organs prolapse surgery, wall of the chest prosthesis, Pituitaryadenoma is performed the operation or the purposes of plastic surgery operations tissue repairing patch.
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