CN110478089A - A kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation - Google Patents
A kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation Download PDFInfo
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- CN110478089A CN110478089A CN201910678130.3A CN201910678130A CN110478089A CN 110478089 A CN110478089 A CN 110478089A CN 201910678130 A CN201910678130 A CN 201910678130A CN 110478089 A CN110478089 A CN 110478089A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
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Abstract
A kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation disclosed by the invention, it includes main part, the main part has been arranged concentrically first passage in the axial direction, the main part is additionally provided with second channel in the axial direction, and the second channel is uniformly arranged centered on the axis of first passage；The main part has been disposed radially third channel, the third channel connection first passage and second channel, so that first passage and the nutrient solution of second channel conveying are spread in tissue via third channel.A kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation provided by the invention, large segmental bone defect is treated suitable for ectopic osteogenesis, its is structurally reasonable, by active scaffold landfill in internal muscle, pass through the double-deck effect of blood vessel and nerve, promote the effect of ectopic osteogenesis, to treat and repair large segmental bone defect.
Description
Technical field
The present invention relates to the field of medical instrument technology more particularly to a kind of vascularization minds suitable for large segmental bone defect reparation
Through being melted into bone active bracket.
Background technique
It is current hair using bone tissue engineer technology treatment bone defect recently as the rapid development of bone tissue engineer
Exhibition trend, ectopic osteogenesis model can reduce the variable for influencing skeletonization in experiment relative to skeletonization in situ, can assess thin at backbone
Born of the same parents, osteogenic induction material effect.Ectopic ossification (HO) refers to the ectopic teratism in normal soft group betided other than bone tissue
Skeletonization is the process of an active development；Ectopic ossification is one kind of ectopic osteogenesis.
Patent CN105013016A discloses a kind of bone defect Regeneration and Repair tissue engineered bone and its construction method and application,
The composite layered structure that tissue engineered bone is made of three layers of mesenchymal stem cell condensate and two layers of bone matrix particle；It is multiple
Closing layered structure is by mesenchymal stem cell condensate-bone matrix particle-mesenchymal stem cell condensate-bone base
Matter particle-mesenchymal stem cell condensate composition complex；Mesenchymal stem cell condensate includes filling between marrow
Matter stem cell and by mesenchymal stem cell secretion and be distributed in the extracellular matrix around mesenchymal stem cell.It should
Method is suitable for bone defect Regeneration and Repair, realizes the physiological regeneration of bone and improves the repairing and treating effect of bone defect.
Patent CN104096266A discloses a kind of tissue engineered bone based on entochondrostosis system, is to do mesenchyma
Cell seeding is in building organizational project complex on porous bone scaffold material, then carries out into cartilage differentiation induction training to it in vitro
It supports 2 weeks, then carries out into loose the culture of cartilage induction 2 weeks and obtaining.The inventive method building based on entochondrostosis
The tissue engineered bone of system can ectopic osteogenesis in vivo, how and success repairing bone defect avoid bulk tissue Engineering Bone
Uniform vascularization and the problem for guaranteeing enough nutrition supplies.
Patent CN108478876A discloses a kind of preparation method of vascularization promoting bone tissue engineering scaffold comprising following step
It is rapid: use chemical precipitation method, by the aqueous solution of containing water-soluble calcium salt, water-soluble copper salt, water-soluble zinc salt and surfactant with
Phosphatic reactant aqueous solution prepares calcium deficiency apatite slurry, after being dried, obtains powder；Wherein, the water-soluble calcium
Salt, water-soluble copper salt, the molar ratio of water-soluble zinc salt are 15~168:1:1；Gained powder is mixed to match with liquid solution and is slurried
Material, is then injected into mold, molding, high temperature sintering is dried, obtain porous calcium phosphate ceramic bracket；The microballoon of GDF-5 will be carried
It is supported on gained porous calcium phosphate ceramic rack surface, the vascularization promoting bone tissue engineering scaffold is obtained after vacuum drying.This
Invention gained tissue engineering bracket has excellent osteoconductive, osteoinductive, biodegradability and vascularization promoting performance, solution
The problem that bone defect of having determined quickly is repaired has good actual application prospect.
Currently, different lack the correlative study that ectopic osteogenesis is used for bone defect healing.Ectopic osteogenesis is used to bone defect to repair
It is multiple, there is special advantage when treating infection of bone bone defect, because the first stage will control when treating infection of bone bone defect
Infection can not carry out skeletonization at bone defect position at this time.And ectopic osteogenesis is carried out using this time, and after infection of bone control
Monolith is transplanted to bone defect position, have than defect be directly placed into tissue engineering bracket faster, better recovery effects.
Therefore, it needs to design a kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation, effectively
Improve the quality and speed of internal ectopic osteogenesis.
Summary of the invention
It is provided by the invention a kind of suitable for large segmental bone defect reparation the purpose of the present invention is in view of the above technical problems
Vascularization neuralization osteogenic activity bracket is suitable for ectopic osteogenesis and treats large segmental bone defect, structurally reasonable, by the active scaffold
It fills in internal muscle, is acted on by blood vessel and the double-deck of nerve, promote the effect of ectopic osteogenesis, to treat and repair big section
Bone defect.
In order to solve the above technical problems, a kind of vascularization neuralization suitable for large segmental bone defect reparation provided by the invention
Osteogenic activity bracket, including main part, the main part have been arranged concentrically first passage in the axial direction, and the main part is along axis
Line direction is additionally provided with second channel, and the second channel is uniformly arranged centered on the axis of first passage；The main part
Third channel has been disposed radially it, the third channel connection first passage and second channel, so that first passage and second logical
The nutrient solution of road conveying is spread in tissue via third channel.
In some embodiments, the diameter of the first passage is greater than the diameter of second channel.
In some embodiments, the diameter of the second channel is the 1/8-1/4 of the diameter of first passage.
In some embodiments, the diameter of the third channel is not more than the diameter of second channel.
In some embodiments, the third channel is horizontally set on main part, the axis of third channel and the main body
The axis in portion is vertical.
In some embodiments, the second channel is uniformly distributed centered on the axis of first passage, also, described second is logical
Road is arranged along the radial direction of main part.
In some embodiments, the third channel is inclined at main part, the axis of third channel and the main body
There are an angles for the axis in portion.
In some embodiments, the angle of the axis of the third channel and the main part is ± 60 °.
In some embodiments, it is provided with hydrogel in the first passage, containing endothelial progenitor cells, to promote in work
Property bracket in formed blood vessel.
In some embodiments, it is provided with hydrogel in the second channel, containing neural stem cell, to promote in work
Property bracket in formed nerve.
The invention has the advantages that:
A kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation provided by the invention, is suitable for
Ectopic osteogenesis treats large segmental bone defect, structurally reasonable, by active scaffold landfill in internal muscle, passes through blood vessel and nerve
The double-deck effect, promote the effect of ectopic osteogenesis, to treat and repair large segmental bone defect；Meanwhile the blood vessel of generation can be carried into
Osteoprogenitor cells needed for bone, oxygen, nutrition and somatomedin (such as hormone etc.) arrive bone surface, the nervous system in bone tissue
The function of osteocyte can be regulated and controled by secretory nerve peptide, play an active part in the bon e formation effect of osteoblast；Furthermore physiological status
Under, nervous system enters bone together with blood vessel, and the two is mutually promoted, and promotes ectopic osteogenesis.
Detailed description of the invention
It will be apparent and be easier reason by made detailed description, above-mentioned advantage of the invention in conjunction with the following drawings
Solution, these attached drawings are only schematical, are not intended to limit the present invention, in which:
Fig. 1 is a kind of knot of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation of the present invention
Structure schematic diagram；
Fig. 2 is the longitdinal cross-section diagram that Fig. 1 corresponds to active scaffold；
Fig. 3 is the view in transverse section that Fig. 1 corresponds to active scaffold；
Fig. 4 is the Electronic Speculum result schematic diagram in Bone Defect Repari portion；
Fig. 5 a and Fig. 5 b are CT reconstructed results display figures.
In figure:
10. main part；11. first passage；12. second channel；13. third channel.
Specific embodiment
Combined with specific embodiments below and attached drawing, to a kind of herein described vascularization suitable for large segmental bone defect reparation
Neuralization osteogenic activity bracket is described in detail.
The embodiment recorded herein is specific specific embodiment of the invention, for illustrating design of the invention,
Be it is explanatory and illustrative, should not be construed as the limitation to embodiment of the present invention and the scope of the invention.Except what is recorded herein
Outside embodiment, those skilled in the art can also based on the claim of this application book and specification disclosure of that using aobvious and
The other technical solutions being clear to, these technical solutions include using any obvious to making for the embodiment recorded herein
The technical solution of substitutions and modifications.
The attached drawing of this specification is schematic diagram, aids in illustrating design of the invention, it is schematically indicated the shape of each section
And its correlation.It note that for the ease of clearly showing the structure of each component of the embodiment of the present invention, identical reference
Label is for indicating identical part.
A kind of structure of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation of the present invention is shown
It is intended to, as shown in Figure 1 to Figure 3 comprising main part 10, the main part 10 have been arranged concentrically first passage in the axial direction
11, the main part 10 is additionally provided with second channel 12 in the axial direction, and the second channel 12 is with the axis of first passage 11
Centered on be uniformly arranged；The main part 10 has been disposed radially third channel 13, and the third channel 13 is connected to first passage
11 with second channel 12 so that the nutrient solution that conveys of first passage 11 and second channel 12 is via third channel 13 in tissue
Interior diffusion.
It is provided with hydrogel in the first passage 11, containing endothelial progenitor cells, to promote to be formed in active scaffold
Blood vessel；It is provided with hydrogel in the second channel 12, containing neural stem cell, to promote to form mind in active scaffold
Through.When carrying out clinical treatment, by active scaffold of the present invention landfill in internal muscle, pass through blood vessel and the bilayer of nerve
Effect, promotes the effect of ectopic osteogenesis, to treat and repair large segmental bone defect, bone ancestral needed for the blood vessel of generation can carry skeletonization
Cell, oxygen, nutrition and somatomedin (such as hormone etc.) arrive bone surface, and the nervous system in bone tissue can pass through secretion mind
Through peptide, regulate and control the function of osteocyte, play an active part in osteoblast bon e formation effect, thus make nervous system together with blood vessel into
Enter bone, the two is mutually promoted, and ectopic osteogenesis is promoted.
As an embodiment of the present invention, the diameter of the first passage 11 is greater than the diameter of second channel 12.Second
The setting in channel 12 enables to the nutrient solution for being passed through first passage 11 in the relatively uniform diffusion in the peripheral side of main part 10；Tool
Body, nutrient solution can be via the peripheral sides for diffusing to main part 10 of third channel 13 and second channel 12, in nutrient solution
Endothelial progenitor cells promote to form blood vessel in active scaffold, and the neural stem cell in nutrient solution promotes to form mind in active scaffold
It is acted on by blood vessel and the double-deck of nerve, to promote ectopic osteogenesis.
As an embodiment of the present invention, the diameter of the second channel 12 is the 1/8-1/4 of 11 diameter of first passage.
Preferably, the diameter of the second channel 12 is the 3/16 of 11 diameter of first passage, nutrient solution can via third channel 13 and
The peripheral side for diffusing to main part 10 of second channel 12.
In some embodiments, the diameter of the third channel 13 is not more than the diameter of second channel 12, third channel 13
It is longitudinally disposed, it is connected to first passage 11 and second channel 12, nutrient solution can be via third channel 13 and second channel 12
The peripheral side of main part 10 is diffused to, the endothelial progenitor cells in nutrient solution promote to form blood vessel in active scaffold, in nutrient solution
Neural stem cell promote in active scaffold formed nerve, keep the endothelium ancestral in first passage 11 thin by third channel 13
Born of the same parents, osteoprogenitor cells, somatomedin carry out contact with the neuropeptide of third channel 13 and exchange, and promote ectopic osteogenesis.
As an embodiment of the present invention, the third channel 13 is horizontally set on main part 10, third channel 13
Axis is vertical with the axis of the main part 10, as shown in Figure 2.As a variant of the present embodiment, the third channel 13
It is inclined at main part 10, there are an angles for the axis of the axis of third channel 13 and the main part 10.In some implementations
In example, the angle of the axis of the third channel 13 and the main part 10 is ± 60 °.Preferably, the third channel 13
The angle of axis and the main part 10 is ± 45 °, i.e., the described third channel 13 can tilt upwards, can also dip down
Tiltedly, it is connected to as long as third channel 13 is opposite with first passage 11 and second channel 12.
In some embodiments, the sectional area of the third channel 13 is identical, can also be set in the form of sectional area gradual change
It sets.Specifically, the sectional area of third channel 13 can become larger from inside to outside, and the nutrient solution of third channel 13 is releived
Conveying promotes active scaffold to the assimilation effect of nutrient solution.
As an embodiment of the present invention, the second channel 12 is uniformly distributed centered on the axis of first passage 11, and
And the second channel 12 is arranged along the radial direction of main part 10, as shown in figure 3, diameter of the second channel 12 along main part 10
To one circle of direction setting；As a kind of variant of the present embodiment, the second channel 12 is arranged along the radial direction of main part 10
Multi-turn, such as two circle second channels 12 or three circle second channels 12, are acted on by blood vessel and the double-deck of nerve, promote ectopic osteogenesis
Effect.
Brief description is living using a kind of vascularization neuralization skeletonization suitable for large segmental bone defect reparation of the present invention
The step of property bracket carries out treatment large segmental bone defect and process:
For infection of bone bone defect, treatment at different stages, first stage are needed, the control of bone defect position is infected, second stage,
Bone defect position bone grafting and Bone Defect Repari.But second part bone grafting then takes bone region to damage if it is implantation autologous bone, and from
Body bone bone amount is limited, is directly placed into tissue engineering bracket, then effect is not good enough.Therefore, we are used for newly using active scaffold
Treatment at different stages method.
Stage 1 is embedded to muscle or subcutaneous, later, bracket in addition to controlling infection of bone, while by prepared active scaffold
The vascular endothelial cell of interior load can be conducive to the vascularization of bracket, and the neural stem cell of load is conducive to the neuralization of bracket, bracket
Vascularization and neuralization facilitate the ectopic osteogenesis of bracket.Specific steps are as follows: special in the experimental animal by ultraviolet light irradiation
It is carried out between surgical procedure, after anesthesia onset, preserved skin is carried out to art area using animal specific shaver；Then, by New Zealand
White Rabbit prostrate carries out disinfection to range inner skin in surgical console, using the medical tincture of iodine, conventional drape, exposure experimental animal
Back；
Then, make two notch for being about 2cm in back backbone two sides, after starting skin, with vessel forceps and tissue shear point
From subcutaneous tissue and fascia superficialis, as deep as fatty deep layer, until appearing muscle fascia superficialis；
Then, pocket-like flesh bag is isolated using blunt separation device, active scaffold of the present invention is used into physiology salt
Water infiltration is laid flat again in flesh bag, then layer-by-layer suture wound, and is marked.
Table 1 is blood examination comparison table, and the Electronic Speculum in Bone Defect Repari portion is as a result, as shown in Figure 4.
1 blood examination of table is surveyed as the result is shown
Table 1 the result shows that, the active scaffold be used for ectopic osteogenesis during, no cytotoxicity.
Stage 2 was used for the active scaffold that a upper stage obtains to treat bone defect, had better effect, specific to walk
Suddenly are as follows: active scaffold ectopic osteogenesis first is replanted into defect to the marrow after 2 weeks；Check experiment are as follows: directly by organizational project branch
Frame is implanted into bone defect position, and table 2 is experiment of machanics comparison table.
2 experiment of machanics comparison table of table
As shown in Table 2, by active scaffold ectopic osteogenesis first replanted after 2 weeks to the marrow defect more directly by organizational project
Stenter to implant bone defect position had better skeletonization effect at 20 weeks.
Fig. 5 a, Fig. 5 b are CT reconstructed results display figure, and skeletonization works well in ectopic osteogenesis active scaffold body, in rabbit radius
In defect model, active scaffold ectopic osteogenesis first is replanted into defect to the marrow after 2 weeks, as described in Fig. 5 a, more directly by group
Weaver's engineering support is implanted into bone defect position, and Figure 5b shows that had better skeletonization effect at 20 weeks.
A kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation provided by the invention, is suitable for
Ectopic osteogenesis treats large segmental bone defect, structurally reasonable, by active scaffold landfill in internal muscle, passes through blood vessel and nerve
The double-deck effect, promote the effect of ectopic osteogenesis, to treat and repair large segmental bone defect, there is preferable promotional value.
The present invention is not limited to the above-described embodiments, anyone can obtain other various forms under the inspiration of the present invention
Product, it is all that there is technical side identical or similar to the present application however, make any variation in its shape or structure
Case is within the scope of the present invention.
Claims (10)
1. a kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation, including main part, the main body
Portion has been arranged concentrically first passage in the axial direction, and the main part is additionally provided with second channel in the axial direction, and described second
Channel is uniformly arranged centered on the axis of first passage；The main part has been disposed radially third channel, and the third is logical
Road is connected to first passage and second channel, so that first passage and the nutrient solution of second channel conveying are via third channel in human body
Diffusion in tissue.
2. a kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation according to claim 1,
It is characterized in that, the diameter of the first passage is greater than the diameter of second channel.
3. a kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation according to claim 2,
It is characterized in that, the diameter of the second channel is the 1/8-1/4 of the diameter of first passage.
4. a kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation according to claim 1,
It is characterized in that, the diameter of the third channel is not more than the diameter of second channel.
5. a kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation according to claim 1,
It is characterized in that, the third channel is horizontally set on main part, the axis of third channel is vertical with the axis of the main part.
6. a kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation according to claim 1,
It is characterized in that, the second channel is uniformly distributed centered on the axis of first passage, also, the second channel is along main part
Radial direction setting.
7. a kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation according to claim 1,
It is characterized in that, the third channel is inclined at main part, the axis presence of the axis of third channel and the main part
One angle.
8. a kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation according to claim 7,
It is characterized in that, the angle of the axis of the third channel and the main part is ± 60 °.
9. a kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation according to claim 1,
It is characterized in that, hydrogel is provided in the first passage, containing endothelial progenitor cells, to promote to be formed in active scaffold
Blood vessel.
10. a kind of vascularization neuralization osteogenic activity bracket suitable for large segmental bone defect reparation according to claim 1,
It is characterized in that, hydrogel is provided in the second channel, containing neural stem cell, to promote to be formed in active scaffold
Nerve.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113768665A (en) * | 2020-06-10 | 2021-12-10 | 上海交通大学医学院附属第九人民医院 | Bone defect repair support, construction method, preparation method, computer-readable storage medium and equipment |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113768665A (en) * | 2020-06-10 | 2021-12-10 | 上海交通大学医学院附属第九人民医院 | Bone defect repair support, construction method, preparation method, computer-readable storage medium and equipment |
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