CN110433011A - It is a kind of for large segmental bone defect treatment auxiliary body in ectopic osteogenesis device - Google Patents

It is a kind of for large segmental bone defect treatment auxiliary body in ectopic osteogenesis device Download PDF

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Publication number
CN110433011A
CN110433011A CN201910678895.7A CN201910678895A CN110433011A CN 110433011 A CN110433011 A CN 110433011A CN 201910678895 A CN201910678895 A CN 201910678895A CN 110433011 A CN110433011 A CN 110433011A
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China
Prior art keywords
bone defect
side plate
auxiliary body
ectopic osteogenesis
large segmental
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Pending
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CN201910678895.7A
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Chinese (zh)
Inventor
张里程
唐佩福
孙国飞
李明
尹鹏滨
崔翔
李飞
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Chinese PLA General Hospital
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Chinese PLA General Hospital
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Priority to CN201910678895.7A priority Critical patent/CN110433011A/en
Publication of CN110433011A publication Critical patent/CN110433011A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30772—Apertures or holes, e.g. of circular cross section
    • A61F2002/30784—Plurality of holes

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  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention discloses ectopic osteogenesis devices in a kind of auxiliary body for large segmental bone defect treatment, it includes main part, the main part includes top plate, side plate and bottom plate, the side plate is overlapped between top plate and bottom plate, the side plate is the component to curving, and top plate, side plate and bottom plate surround the cavity of single-open；The device of ectopic osteogenesis device further includes perfusion tube in the auxiliary body for large segmental bone defect treatment, and the perfusion tube is removably connected to the formation conveying nutrient solution for thinking ectopic osteogenesis with the cavity.Ectopic osteogenesis device in a kind of auxiliary body for large segmental bone defect treatment provided by the invention, large segmental bone defect is treated suitable for ectopic osteogenesis, its is structurally reasonable, it is ingenious in design, it is open in the unilateral setting of cavity for tissue engineering bracket, allogeneic aggregate to be arranged, multiple micropores are set in the side plate for forming cavity simultaneously, mass exchange has been effectively ensured, has improved the therapeutic effect of large segmental bone defect.

Description

It is a kind of for large segmental bone defect treatment auxiliary body in ectopic osteogenesis device
Technical field
The present invention relates to different in the field of medical instrument technology more particularly to a kind of auxiliary body for large segmental bone defect treatment Position is at bone device.
Background technique
It is current hair using bone tissue engineer technology treatment bone defect recently as the rapid development of bone tissue engineer Exhibition trend, ectopic osteogenesis model can reduce the variable for influencing skeletonization in experiment relative to skeletonization in situ, can assess thin at backbone Born of the same parents, osteogenic induction material effect.Ectopic ossification (HO) refers to the ectopic teratism in normal soft group betided other than bone tissue Skeletonization is the process of an active development；Ectopic ossification is one kind of ectopic osteogenesis.
Patent CN1279973C discloses a kind of gel-type bone restoration bioactive material and preparation method thereof of injection, should Each of material is made of using unit component A and 45~55mg B component, wherein component A is by 10~40mg of sodium alginate, bone 0.1~1mg of morphogenetic proteins, 10~20mg of mannitol are formed, and are contained in the every mg of B component: slightly water-soluble calcium compound 0.0498~0.1476mg, 0.0498~0.2953mg of glucolactone, 0.0040~0.0157mg of polyvinylpyrrolidone, Surplus is mannitol.This injected bone repairing material good biocompatibility can be implanted into bone without operation using handy and safe Section patient position in need for the treatment of.Zoopery proves its osteogenic activity and needs that egg occurs containing Bones morphology by operation implantation White solid-state bone renovating material is suitable.
Patent CN105013016A discloses a kind of bone defect Regeneration and Repair tissue engineered bone and its construction method and application, The composite layered structure that tissue engineered bone is made of three layers of mesenchymal stem cell condensate and two layers of bone matrix particle；It is multiple Closing layered structure is by mesenchymal stem cell condensate-bone matrix particle-mesenchymal stem cell condensate-bone base Matter particle-mesenchymal stem cell condensate composition complex；Mesenchymal stem cell condensate includes filling between marrow Matter stem cell and by mesenchymal stem cell secretion and be distributed in the extracellular matrix around mesenchymal stem cell.It should Method is suitable for bone defect Regeneration and Repair, realizes the physiological regeneration of bone and improves the repairing and treating effect of bone defect.
Patent CN104096266A discloses a kind of tissue engineered bone based on entochondrostosis system, is to do mesenchyma Cell seeding is in building organizational project complex on porous bone scaffold material, then carries out into cartilage differentiation induction training to it in vitro It supports 2 weeks, then carries out into loose the culture of cartilage induction 2 weeks and obtaining.The inventive method building based on entochondrostosis The tissue engineered bone of system can ectopic osteogenesis in vivo, how and success repairing bone defect avoid bulk tissue Engineering Bone Uniform vascularization and the problem for guaranteeing enough nutrition supplies.
Patent CN108478876A discloses a kind of preparation method of vascularization promoting bone tissue engineering scaffold comprising following step It is rapid: use chemical precipitation method, by the aqueous solution of containing water-soluble calcium salt, water-soluble copper salt, water-soluble zinc salt and surfactant with Phosphatic reactant aqueous solution prepares calcium deficiency apatite slurry, after being dried, obtains powder；Wherein, the water-soluble calcium Salt, water-soluble copper salt, the molar ratio of water-soluble zinc salt are 15~168:1:1；Gained powder is mixed to match with liquid solution and is slurried Material, is then injected into mold, molding, high temperature sintering is dried, obtain porous calcium phosphate ceramic bracket；The microballoon of GDF-5 will be carried It is supported on gained porous calcium phosphate ceramic rack surface, the vascularization promoting bone tissue engineering scaffold is obtained after vacuum drying.This Invention gained tissue engineering bracket has excellent osteoconductive, osteoinductive, biodegradability and vascularization promoting performance, solution The problem that bone defect of having determined quickly is repaired has good actual application prospect.
Currently, lacking the correlative study that ectopic osteogenesis is used for bone defect healing.Ectopic osteogenesis is used for bone defect healing, There is special advantage when treating infection of bone bone defect, because the first stage will control sense when treating infection of bone bone defect Dye can not carry out skeletonization at bone defect position at this time.And ectopic osteogenesis is carried out using this time, and whole after infection of bone control Block is transplanted to bone defect position, have than defect be directly placed into tissue engineering bracket faster, better recovery effects.But such as The method of this ectopic osteogenesis of fruit is preferably formed with a kind of shell dedicated for carrying tissue engineering bracket, can be convenient behaviour Make, while promoting ectopic osteogenesis.
Therefore, it needs to design ectopic osteogenesis device in a kind of auxiliary body for large segmental bone defect treatment, effectively improves body The quality and speed of interior ectopic osteogenesis.
Summary of the invention
It is provided by the invention a kind of for the auxiliary of large segmental bone defect treatment the purpose of the present invention is in view of the above technical problems Ectopic osteogenesis device in body aid is suitable for ectopic osteogenesis and treats large segmental bone defect, structurally reasonable, ingenious in design, in cavity Unilateral side setting is open for tissue engineering bracket, allogeneic aggregate to be arranged, while multiple micro- in the side plate setting for forming cavity Mass exchange has been effectively ensured in hole, improves the therapeutic effect of large segmental bone defect.
In order to solve the above technical problems, it is provided by the invention it is a kind of for large segmental bone defect treatment auxiliary body in dystopy at Bone device, including main part, the main part include top plate, side plate and bottom plate, and the side plate is overlapped between top plate and bottom plate, The side plate is the component to curving, and top plate, side plate and bottom plate surround the cavity of single-open；It is described to be lacked for big section bone The device for damaging ectopic osteogenesis device in the auxiliary body for the treatment of further includes perfusion tube, and the perfusion tube removably connects with the cavity It passes to and conveys nutrient solution for the formation of ectopic osteogenesis.
In some embodiments, the cross sectional shape of the side plate is circular part, and the top plate and bottom plate matching are arranged, So that the both ends of side plate and the lateral overlap of top plate and bottom plate are fixed.
In some embodiments, the cross sectional shape of the side plate is the part of ellipse, and the top plate and bottom plate matching are set It sets, so that the both ends of side plate and the lateral overlap of top plate and bottom plate are fixed.
In some embodiments, the top plate, side plate and bottom plate are integrated, and three surrounds the sky of single-open Chamber.
In some embodiments, multiple micropores are provided on the side plate, to carry out substance friendship with the external of the cavity It changes.
In some embodiments, the micropore is uniformly arranged on side plate.
In some embodiments, the sectional area of the micropore is not more than 0.5mm2。
In some embodiments, the shape of the micropore be circle, ellipse, triangle, rectangle it is any.
In some embodiments, the top plate, side plate and bottom plate are elastic component.
In some embodiments, the top plate, side plate and bottom plate are polylactic acid, poly lactide-glycolide acid, gather oneself Any composition of lactone, polyglycolic acid, bio-vitric.
The invention has the advantages that:
Provided by the present invention for ectopic osteogenesis device in the auxiliary body of large segmental bone defect treatment, controlled suitable for ectopic osteogenesis Treat large segmental bone defect, it is structurally reasonable, it is ingenious in design, cavity unilateral setting opening for tissue engineering bracket, same to be arranged Kind of allosome aggregate makes skeletonization shape intramuscular is tissue engineering bracket, the placement of the components such as different bone material of the same race provides space Rule, and convenient for taking bone to operate, while multiple micropores are set in the side plate for forming cavity, mass exchange has been effectively ensured, has created Perfusion tube with the cavity removably be connected to convenient for for ectopic osteogenesis formed initial stage supplement conveying nutrient solution, promote into Bone mass and speed improve the therapeutic effect of large segmental bone defect.
Detailed description of the invention
It will be apparent and be easier reason by made detailed description, above-mentioned advantage of the invention in conjunction with the following drawings Solution, these attached drawings are only schematical, are not intended to limit the present invention, in which:
Fig. 1 is the structural representation of ectopic osteogenesis device in a kind of auxiliary body for large segmental bone defect treatment of the present invention Figure；
Fig. 2 is another embodiment of ectopic osteogenesis device in a kind of auxiliary body for large segmental bone defect treatment of the present invention Structural schematic diagram；
Fig. 3 is that Alizarin red staining is schemed as the result is shown；
Fig. 4 a and Fig. 4 b are substantially to scheme as the result is shown.
In figure:
10. main part；11. top plate；12. side plate；13. bottom plate；14. cavity；15. micropore；20. perfusion tube.
Specific embodiment
Combined with specific embodiments below and attached drawing, in a kind of herein described auxiliary body for large segmental bone defect treatment Ectopic osteogenesis device is described in detail.
The embodiment recorded herein is specific specific embodiment of the invention, for illustrating design of the invention, Be it is explanatory and illustrative, should not be construed as the limitation to embodiment of the present invention and the scope of the invention.Except what is recorded herein Outside embodiment, those skilled in the art can also based on the claim of this application book and specification disclosure of that using aobvious and The other technical solutions being clear to, these technical solutions include using any obvious to making for the embodiment recorded herein The technical solution of substitutions and modifications.
The attached drawing of this specification is schematic diagram, aids in illustrating design of the invention, it is schematically indicated the shape of each section And its correlation.It note that for the ease of clearly showing the structure of each component of the embodiment of the present invention, identical reference Label is for indicating identical part.
The structural schematic diagram of ectopic osteogenesis device in a kind of auxiliary body for large segmental bone defect treatment of the present invention, such as Shown in Fig. 1, which is arranged in the muscle at defect of human body bone position comprising main part 10, the main part 10 include top Plate 11, side plate 12 and bottom plate 13, the side plate 12 are overlapped between top plate 11 and bottom plate 13, and the side plate 12 is to curving Component, top plate 11, side plate 12 and bottom plate 13 surround the cavity 14 of single-open；The auxiliary for large segmental bone defect treatment The device of internal ectopic osteogenesis device further includes perfusion tube 20, and the perfusion tube 20 is removably connected to the cavity 14 to be convenient for For the initial stage supplement conveying nutrient solution that ectopic osteogenesis is formed, skeletonization quality and speed are promoted, the later period is detachable.
As an embodiment of the present invention, the cavity for the single-open that the top plate 11, side plate 12 and bottom plate 13 surround It is provided with the components such as tissue engineering bracket, allogeneic aggregate in 14, mass exchange has been effectively ensured；Main part 10 has simultaneously Certain rigidity can guarantee the stability of structure, prevent top plate 11, side plate 12 or bottom plate 13 intensity deficiency in main part 10 And cause the component of the cavity 14 damaged, good growing environment is provided for ectopic osteogenesis.
As the one aspect of the present embodiment, the cross sectional shape of the side plate 12 is circular part, the top plate 11 and The matching setting of bottom plate 13, so that the both ends of side plate 12 and the lateral overlap of top plate 11 and bottom plate 13 are fixed.As a kind of variant, institute It states top plate 11, side plate 12 and bottom plate 13 to be integrated, three surrounds the cavity 14 of single-open.
As the other side of the present embodiment, the cross sectional shape of the side plate 12 is the part of ellipse, such as Fig. 2 institute Show, the top plate 11 and the matching setting of bottom plate 13, so that the both ends of side plate 12 and the lateral overlap of top plate 11 and bottom plate 13 are fixed. As a kind of variant, the top plate 11, side plate 12 and bottom plate 13 are integrated, and three surrounds the cavity 14 of single-open. It is understood that the cross sectional shape of the side plate 12 may be other irregular shapes, as long as side plate 12 is to a lateral bending Song so that side plate 12 and top plate 11 and bottom plate 13 form the cavity 12 of single-open, intramuscular be tissue engineering bracket, it is of the same race The placement of the components such as different bone material provides space, keeps skeletonization shape regular, and convenient for taking bone to operate.
As an embodiment of the present invention, multiple micropores 15 are provided on the side plate 12, it is as shown in Figures 1 and 2, micro- The setting in hole 15 enables to the component of cavity 14 and the external of the cavity 14 to carry out mass exchange.
As the one aspect of the present embodiment, the micropore 15 is uniformly arranged on side plate 12, to guarantee inside and outside cavity The smooth progress of mass exchange.As a kind of variant of the present embodiment, the micropore 15 can also be distributed approximately evenly in side plate 12 On；In other embodiments, the top plate 11 and bottom plate 13 may also set up micropore 15, and the substantially uniform setting of micropore 15 exists On top plate 11 and bottom plate 13, guarantee the smooth progress of mass exchange inside and outside cavity 14, while guaranteeing the intensity of main part 10.
As an embodiment of the present invention, the sectional area of the micropore 15 is not more than 0.5mm2, it is preferred that the micropore 15 sectional area is 0.3mm2。
In some embodiments, the shape of the micropore 15 be circle, ellipse, triangle, rectangle it is any.As One of the present embodiment variant, 15 shape of micropore can also be any two kinds, three kinds or a variety of of combination, as long as can protect The intensity of main part 10 is demonstrate,proved, while guaranteeing the mass exchange smoothness inside and outside cavity 14.
As an embodiment of the present invention, the top plate 11, side plate 12 and bottom plate 13 are elastic component, to guarantee top plate 11, the components such as tissue engineering bracket, allogeneic aggregate can be set inside the cavity 14 that side plate 12 and bottom plate 13 are formed；One In a little embodiments, the top plate 11, side plate 12 and bottom plate 13 be polylactic acid, poly lactide-glycolide acid, polycaprolactone, Any composition of polyglycolic acid, bio-vitric, to improve the therapeutic effect of large segmental bone defect.
Ectopic osteogenesis operation is carried out in the experimental animal Special surgical operation room by ultraviolet light irradiation, to anesthesia onset Afterwards, preserved skin is carried out to art area using animal specific shaver.By new zealand white rabbit prostrate in surgical console, Medical iodine prevention is utilized Wine carries out disinfection to range inner skin, conventional drape, and exposure experimental animal back makees two in back backbone two sides and is about 2cm Notch, after starting skin, with vessel forceps and tissue shear separation subcutaneous tissue and fascia superficialis, as deep as fatty deep layer, until appearing Muscle fascia superficialis isolates pocket-like flesh bag with blunt separation device, after carrying tissue engineering bracket in the device, with physiology salt Water infiltration, then lay flat in flesh bag, perfusion tube 20 exposes skin, then layer-by-layer suture wound, and marks.
Table 1 is blood examination comparison table, and Fig. 3 is put into the bone tissue engineering scaffold of 3D printing, ectopic osteogenesis training in a device After supporting 2 weeks, Alizarin red staining is shown, has good skeletonization effect.
1 blood examination of table is surveyed as the result is shown
Table 1 the result shows that, the organization bracket be used for ectopic osteogenesis during, no cytotoxicity.
Tissue engineering bracket ectopic osteogenesis first is replanted into defect to the marrow after 2 weeks；Check experiment are as follows: directly by tissue Engineering rack is implanted into bone defect position, and table 2 is experiment of machanics comparison table.
2 experiment of machanics comparison table of table
As shown in Table 2, by tissue engineering bracket ectopic osteogenesis first replanted after 2 weeks to the marrow defect more directly by tissue Engineering rack is implanted into bone defect position, has better skeletonization effect at 20 weeks.
Fig. 4 a, Fig. 4 b are skeletonization effect pictures in ectopic osteogenesis support body, will using the device in rabbit critical size defects Tissue engineering bracket is replanted defect to the marrow first after intramuscular ectopic osteogenesis 2 weeks by tissue engineering bracket, such as Fig. 4 a institute Show；Tissue engineering bracket is directly implanted into bone defect position, Fig. 4 b is shown；Tissue engineering bracket 2 Zhou Houzai of ectopic osteogenesis first It is implanted into bone defect position and tissue engineering bracket is more directly implanted into bone defect position, there is better skeletonization effect at 20 weeks.
It is provided by the invention it is a kind of for large segmental bone defect treatment auxiliary body in ectopic osteogenesis device, be suitable for dystopy at Bone-specific drug large segmental bone defect, it is structurally reasonable, it is ingenious in design, it is open in the unilateral setting of cavity for organizational project branch to be arranged Frame, allogeneic aggregate make into intramuscular is tissue engineering bracket, the placement of the components such as different bone material of the same race provides space Bone shape rule, and convenient for taking bone to operate, while multiple micropores are set in the side plate for forming cavity, substance friendship has been effectively ensured It changes, improves the therapeutic effect of large segmental bone defect, there is preferable promotional value.
The present invention is not limited to the above-described embodiments, anyone can obtain other various forms under the inspiration of the present invention Product, it is all that there is technical side identical or similar to the present application however, make any variation in its shape or structure Case is within the scope of the present invention.

Claims (10)

1. ectopic osteogenesis device in a kind of auxiliary body for large segmental bone defect treatment, including main part, the main part include Top plate, side plate and bottom plate, the side plate are overlapped between top plate and bottom plate, the side plate be to curving component, top plate, Side plate and bottom plate surround the cavity of single-open；The dress of ectopic osteogenesis device in the auxiliary body for large segmental bone defect treatment Setting further includes perfusion tube, and the perfusion tube is removably connected to the formation conveying nutrient solution for thinking ectopic osteogenesis with the cavity.
2. ectopic osteogenesis device in the auxiliary body according to claim 1 for large segmental bone defect treatment, which is characterized in that The cross sectional shape of the side plate is circular part, the top plate and bottom plate matching setting so that the both ends of side plate and top plate and The lateral overlap of bottom plate is fixed.
3. ectopic osteogenesis device in the auxiliary body according to claim 1 for large segmental bone defect treatment, which is characterized in that The cross sectional shape of the side plate is the part of ellipse, the top plate and bottom plate matching setting, so that the both ends of side plate and top plate And the lateral overlap of bottom plate is fixed.
4. ectopic osteogenesis device in the auxiliary body according to claim 1 for large segmental bone defect treatment, which is characterized in that The top plate, side plate and bottom plate are integrated, and three surrounds the cavity of single-open.
5. ectopic osteogenesis device in the auxiliary body according to claim 1 for large segmental bone defect treatment, which is characterized in that Multiple micropores are provided on the side plate, to carry out mass exchange with the external of the cavity.
6. ectopic osteogenesis device in the auxiliary body according to claim 5 for large segmental bone defect treatment, which is characterized in that The micropore is uniformly arranged on side plate.
7. ectopic osteogenesis device in the auxiliary body according to claim 5 for large segmental bone defect treatment, which is characterized in that The sectional area of the micropore is not more than 0.5mm2。
8. ectopic osteogenesis device in the auxiliary body according to claim 5 for large segmental bone defect treatment, which is characterized in that The shape of the micropore be circle, ellipse, triangle, rectangle it is any.
9. ectopic osteogenesis device in the auxiliary body according to claim 1 for large segmental bone defect treatment, which is characterized in that The top plate, side plate and bottom plate are elastic component.
10. ectopic osteogenesis device in the auxiliary body according to claim 9 for large segmental bone defect treatment, feature exist In the top plate, side plate and bottom plate are polylactic acid, poly lactide-glycolide acid, polycaprolactone, polyglycolic acid, biology Any composition of glass.
CN201910678895.7A 2019-07-25 2019-07-25 It is a kind of for large segmental bone defect treatment auxiliary body in ectopic osteogenesis device Pending CN110433011A (en)

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CN201910678895.7A CN110433011A (en) 2019-07-25 2019-07-25 It is a kind of for large segmental bone defect treatment auxiliary body in ectopic osteogenesis device

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