CN210843630U - Auxiliary in-vivo ectopic osteogenesis device for treating large-section bone defect - Google Patents
Auxiliary in-vivo ectopic osteogenesis device for treating large-section bone defect Download PDFInfo
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Abstract
The utility model discloses an ectopic osteogenesis device in an auxiliary body for treating large-section bone defects, which comprises a main body part, wherein the main body part comprises a top plate, a side plate and a bottom plate, the side plate is lapped between the top plate and the bottom plate, the side plate is a component bent to one side, and the top plate, the side plate and the bottom plate enclose a cavity with an opening at one side; the device of the auxiliary in-vivo ectopic osteogenesis device for treating the large-section bone defect also comprises an infusion tube, wherein the infusion tube is detachably communicated with the cavity to deliver nutrient solution for the formation of ectopic osteogenesis. The utility model provides a pair of dystopy osteogenesis device in auxiliary body for damaged treatment of big section bone is applicable to the dystopy osteogenesis and treats big section bone defect, and its is rational in infrastructure, and design benefit sets up the opening and is used for setting up tissue engineering support, allogeneic aggregate in the unilateral of cavity, sets up a plurality of micropores at the curb plate of vacuole formation simultaneously, has effectively guaranteed the material exchange, improves the damaged treatment of big section bone.
Description
Technical Field
The utility model relates to the technical field of medical equipment, especially, relate to an auxiliary body ectopic osteogenesis device for big section bone defect treatment.
Background
With the rapid development of bone tissue engineering in recent years, the bone defect treatment by applying the bone tissue engineering technology is the current development trend, and compared with in-situ osteogenesis, the ectopic osteogenesis model can reduce the variables influencing osteogenesis in experiments and can evaluate the effects of osteogenic stem cells and osteogenesis inducing materials. Ectopic ossification (HO), which is a dynamically developing process, refers to ectopic malformed osteogenesis occurring in normal soft tissues other than bone tissues; ectopic ossification is one of ectopic osteogenesis.
Patent CN1279973C discloses an injectable gel-type bone repair bioactive material and a preparation method thereof, each use unit of the material consists of a component A and a component B of 45-55 mg, wherein the component A consists of 10-40 mg of sodium alginate, 0.1-1 mg of bone morphogenetic protein and 10-20 mg of mannitol, and each mg of the component B contains: 0.0498-0.1476 mg of water-insoluble calcium compound, 0.0498-0.2953 mg of gluconolactone, 0.0040-0.0157 mg of polyvinylpyrrolidone and the balance of mannitol. The injection type bone repair material has good biocompatibility, is simple and safe to use, and can be implanted into the part of an orthopedic patient needing treatment without an operation. Animal experiments prove that the osteogenic activity of the bone repair material is equivalent to that of a solid bone repair material containing bone morphogenetic protein and needing to be implanted through operation.
Patent CN105013016A discloses a tissue engineering bone for bone defect regeneration and repair, its construction method and application, the tissue engineering bone is a composite lamellar structure composed of three layers of bone marrow mesenchymal stem cell polymer and two layers of bone matrix particles; the composite layered structure is a complex consisting of bone marrow mesenchymal stem cell polymer-bone matrix particle-bone marrow mesenchymal stem cell polymer; the bone marrow mesenchymal stem cell aggregate comprises bone marrow mesenchymal stem cells and extracellular matrix which is secreted by the bone marrow mesenchymal stem cells and distributed around the bone marrow mesenchymal stem cells. The method is suitable for bone defect regeneration and repair, realizes bone physiological regeneration, and improves bone defect repair and treatment effects.
Patent CN104096266A discloses a tissue engineering bone based on an endochondral osteogenesis system, which is obtained by planting mesenchymal stem cells on a porous bone scaffold material to construct a tissue engineering complex, then performing chondrogenic differentiation induction culture for 2 weeks in vitro, and then performing hypertrophic cartilage differentiation induction culture for 2 weeks. The utility model discloses a tissue engineering bone based on bone system in cartilage that the method was founded can be in internal dystopy bone formation to successfully repair the bone defect, avoided the difficult problem of how even vascularization of big piece tissue engineering bone and assurance sufficient nutrition supply.
Patent CN108478876A discloses a preparation method of a vascularization promoting bone tissue engineering scaffold, which comprises the following steps: reacting an aqueous solution containing water-soluble calcium salt, water-soluble copper salt, water-soluble zinc salt and a surfactant with an aqueous solution of phosphate by adopting a chemical precipitation method to prepare calcium-deficient apatite slurry, and drying to obtain powder; wherein the molar ratio of the water-soluble calcium salt to the water-soluble copper salt to the water-soluble zinc salt is 15-168: 1: 1; mixing the obtained powder with the liquid phase solution to prepare slurry, injecting the slurry into a mold, and performing drying molding and high-temperature sintering to obtain a porous calcium phosphate ceramic support; and loading the microspheres carrying GDF-5 on the surface of the obtained porous calcium phosphate ceramic scaffold, and drying in vacuum to obtain the vascularization promoting bone tissue engineering scaffold. The utility model discloses gained tissue engineering support has good osteoconductivity, osteoinduction, biodegradability and the vascularization ability of promoting, has solved the quick prosthetic difficult problem of bone defect, has good practical application prospect.
Currently, there is a lack of research relating to the use of ectopic osteogenesis for bone defect repair. The use of ectopic osteogenesis for bone defect repair is particularly advantageous in the treatment of bone-infected bone defects, where infection is controlled in the first stage, where osteogenesis is not possible at the site of the bone defect. The ectopic bone formation is carried out by utilizing the time, and the whole bone is transplanted to the bone defect part after the bone infection is controlled, so that the recovery effect is quicker and better than the recovery effect of directly placing the tissue engineering scaffold into the defect part. However, if the method of ectopic osteogenesis is to be used, it is desirable to have a housing specially used for carrying a tissue engineering scaffold, which can facilitate the operation and promote ectopic osteogenesis.
Therefore, there is a need to design an auxiliary in vivo ectopic osteogenesis device for treating large bone defect, which can effectively improve the quality and speed of in vivo ectopic osteogenesis.
SUMMERY OF THE UTILITY MODEL
The utility model aims at the above-mentioned technical problem, the utility model provides a pair of a device is osteogenesis to dystopy in auxiliary body for damaged treatment of big section bone is applicable to heterotopic osteogenesis treatment big section bone and is defective, its is rational in infrastructure, and design benefit sets up the opening and is used for setting up tissue engineering support, allogeneic aggregate in the unilateral of cavity, sets up a plurality of micropores at the curb plate of vacuole formation simultaneously, has effectively guaranteed the material exchange, improves the damaged treatment of big section bone.
In order to solve the technical problem, the utility model provides an auxiliary in-vivo ectopic osteogenesis device for treating large bone defects, which comprises a main body part, wherein the main body part comprises a top plate, a side plate and a bottom plate, the side plate is lapped between the top plate and the bottom plate, the side plate is a member bent to one side, and the top plate, the side plate and the bottom plate enclose a cavity with a single-side opening; the device of the auxiliary in-vivo ectopic osteogenesis device for treating the large-section bone defect also comprises an infusion tube, wherein the infusion tube is detachably communicated with the cavity to deliver nutrient solution for the formation of ectopic osteogenesis.
In some embodiments, the cross-sectional shape of the side plate is a circular part, and the top plate and the bottom plate are arranged in a matching manner, so that two ends of the side plate are fixed with the outer sides of the top plate and the bottom plate in an overlapping manner.
In some embodiments, the cross-sectional shape of the side plate is a partial oval, and the top plate and the bottom plate are arranged in a matching manner, so that two ends of the side plate are fixed with the outer sides of the top plate and the bottom plate in an overlapping manner.
In some embodiments, the top plate, the side plate and the bottom plate are of an integrated structure, and the top plate, the side plate and the bottom plate define a cavity with a single side opening.
In some embodiments, the side plate is provided with a plurality of micro-holes for exchanging substances with the outside of the cavity.
In some embodiments, the micro-holes are uniformly disposed on the side plates.
In some embodiments, the cross-sectional area of the micropores is no greater than 0.5mm2。
In some embodiments, the shape of the microwells is any one of circular, oval, triangular and rectangular.
In some embodiments, the top plate, the side plates, and the bottom plate are elastic members.
In some embodiments, the top plate, the side plates and the bottom plate are made of any one of polylactic acid, polylactic acid-glycolic acid copolymer, polycaprolactone, polyglycolic acid and bioglass.
The utility model discloses beneficial effect:
the utility model provides an ectopic osteogenesis device in auxiliary body for big section bone defect treatment, be applicable to the big section bone defect of ectopic osteogenesis treatment, it is rational in infrastructure, design benefit sets up the opening and is used for setting up tissue engineering support, the allogeneic aggregate in the unilateral of cavity, for tissue engineering support, the placing of subassembly such as allogeneic xenogeneic bone material provides the space in muscle, make osteogenesis appearance rule, and be convenient for get the bone operation, set up a plurality of micropores at the curb plate of vacuole formation simultaneously, effectively guaranteed the material exchange, original transfer line with cavity detachable intercommunication is convenient for carry the nutrient solution for the initial stage replenishment of ectopic osteogenesis formation, has promoted osteogenesis quality and speed, improves big section bone defect treatment.
Drawings
The above advantages of the present invention will become more apparent and more readily appreciated from the detailed description taken in conjunction with the following drawings, which are given by way of illustration only and do not limit the present invention, and in which:
fig. 1 is a schematic structural view of an auxiliary in-vivo ectopic osteogenesis device for treating a large bone defect according to the present invention;
fig. 2 is a schematic structural view of another embodiment of an assisted in vivo ectopic osteogenesis device for the treatment of a large bone defect according to the present invention;
FIG. 3 is a graph showing the result of alizarin red staining;
FIGS. 4a and 4b are general results graphs.
In the figure:
10. a main body portion; 11. a top plate; 12. a side plate; 13. a base plate; 14. a cavity; 15. micropores; 20. an infusion tube.
Detailed Description
An assisted in vivo ectopic osteogenesis device for the treatment of a large bone defect according to the present application will be described in detail with reference to the following embodiments and accompanying drawings.
The embodiments described herein are specific embodiments of the present invention, and are intended to be illustrative of the concepts of the present invention, which are intended to be illustrative and exemplary, and should not be construed as limiting the scope of the embodiments of the present invention. In addition to the embodiments described herein, those skilled in the art will be able to employ other technical solutions which are obvious based on the disclosure of the claims and the specification of the present application, and these technical solutions include technical solutions which make any obvious replacement or modification for the embodiments described herein.
The drawings in the present specification are schematic views to assist in explaining the concept of the present invention, and schematically show the shapes of the respective portions and the mutual relationships thereof. Note that, in order to clearly show the structure of each component of the embodiment of the present invention, the same reference numerals are used to denote the same parts.
The utility model relates to a structural schematic diagram of an auxiliary in-vivo heterotopic osteogenesis device for large bone defect treatment, as shown in figure 1, the device is arranged in the muscle of human bone defect position, and comprises a main body part 10, the main body part 10 comprises a top plate 11, a side plate 12 and a bottom plate 13, the side plate 12 is lapped between the top plate 11 and the bottom plate 13, the side plate 12 is a component bending to one side, and the top plate 11, the side plate 12 and the bottom plate 13 enclose a cavity 14 with a single-side opening; the device of the auxiliary in-vivo ectopic osteogenesis device for treating the large bone defect also comprises an infusion tube 20, wherein the infusion tube 20 is detachably communicated with the cavity 14 so as to conveniently supplement and convey nutrient solution for the early stage formed by the ectopic osteogenesis, thereby promoting the osteogenesis quality and speed, and being detachable at the later stage.
As an embodiment of the present invention, the cavity 14 with a single side opening, which is enclosed by the top plate 11, the side plate 12 and the bottom plate 13, is internally provided with components such as tissue engineering scaffold, allogeneic aggregate and the like, so that the material exchange is effectively ensured; meanwhile, the main body part 10 has certain rigidity, so that the stability of the structure can be ensured, the damage of the components of the cavity 14 caused by insufficient strength of the top plate 11, the side plate 12 or the bottom plate 13 in the main body part 10 can be prevented, and a good growth environment is provided for ectopic osteogenesis.
In one aspect of this embodiment, the cross-sectional shape of the side plate 12 is a circular part, and the top plate 11 and the bottom plate 13 are disposed in a matching manner, so that two ends of the side plate 12 are fixed to the outer sides of the top plate 11 and the bottom plate 13 in an overlapping manner. As a variant, the top plate 11, the side plate 12 and the bottom plate 13 are an integrated structure, and they enclose a cavity 14 with a single side opening.
In another aspect of the present embodiment, the cross-sectional shape of the side plate 12 is a partial oval, and as shown in fig. 2, the top plate 11 and the bottom plate 13 are disposed in a matching manner, so that both ends of the side plate 12 are fixed to the outer sides of the top plate 11 and the bottom plate 13 in an overlapping manner. As a variant, the top plate 11, the side plate 12 and the bottom plate 13 are an integrated structure, and they enclose a cavity 14 with a single side opening. It should be understood that the cross-sectional shape of the side plate 12 may be other irregular shapes as long as the side plate 12 is bent to one side, so that the side plate 12, the top plate 11 and the bottom plate 13 form a cavity 12 with a single side opening, and space is provided for placing tissue engineering scaffold, homogeneous bone material and other components in the muscle, so that the bone formation has a regular shape, and the bone extraction operation is facilitated.
As an embodiment of the present invention, a plurality of micropores 15 are disposed on the side plate 12, as shown in fig. 1 and fig. 2, the arrangement of the micropores 15 enables the components of the cavity 14 to exchange substances with the outside of the cavity 14.
As an aspect of the present embodiment, the micro holes 15 are uniformly formed on the side plate 12 to ensure that the material exchange between the inside and the outside of the cavity is smoothly performed. As a variant of this embodiment, the microholes 15 can also be substantially uniformly distributed on the side plate 12; in another embodiment, the top plate 11 and the bottom plate 13 may be provided with the micro holes 15, and the micro holes 15 may be substantially uniformly formed in the top plate 11 and the bottom plate 13, so that the smooth exchange of the substance inside and outside the cavity 14 is ensured, and the strength of the main body 10 is ensured.
As an embodiment of the present invention, the cross-sectional area of the micro-holes 15 is not more than 0.5mm2Preferably, the cross-sectional area of the micro-holes 15 is 0.3mm2。
In some embodiments, the shape of the micro-holes 15 is any one of circular, oval, triangular and rectangular. As a variation of this embodiment, the shape of the micro-hole 15 may be any combination of two, three or more, as long as the strength of the main body 10 is ensured and the smooth exchange of substances inside and outside the cavity 14 is ensured.
As an embodiment of the present invention, the top plate 11, the side plates 12 and the bottom plate 13 are elastic members to ensure that components such as tissue engineering scaffold, allogeneic aggregate and the like can be arranged inside the cavity 14 formed by the top plate 11, the side plates 12 and the bottom plate 13; in some embodiments, the top plate 11, the side plates 12 and the bottom plate 13 are made of any one of polylactic acid, polylactic acid-glycolic acid copolymer, polycaprolactone, polyglycolic acid and bioglass, so as to improve the treatment effect of the large bone defect.
The ectopic osteogenesis operation is carried out in an operation room special for experimental animals irradiated by ultraviolet rays, and after the anesthesia takes effect, a shaver special for animals is used for skin preparation of an operation area. Placing a New Zealand white rabbit prostrating on an operation operating table, disinfecting skin within a range by using medical iodine tincture, conventionally paving a towel, exposing the back of an experimental animal, making two incisions with the length of about 2cm on two sides of the spine of the back, lifting the skin, separating subcutaneous tissue and superficial fascia by using vascular forceps and tissue scissors until the deep fat layer is reached until the superficial fascia of muscle is exposed, separating an outlet bag-shaped muscle bag by using a blunt separator, infiltrating the tissue engineering scaffold in the device by using physiological saline, flatly placing the tissue bag in the muscle bag, exposing the skin by using a liquid conveying pipe 20, suturing the wound layer by layer, and marking.
Table 1 is a blood examination result comparison table, and fig. 3 shows that alizarin red staining shows that the device has good osteogenesis effect after placing a 3D printed bone tissue engineering scaffold in the device and culturing ectopic osteogenesis for 2 weeks.
Table 1 blood test results display
The results in table 1 show that the tissue scaffolds are not cytotoxic when used in ectopic osteogenesis.
Firstly ectopically forming bones for 2 weeks and then implanting the tissue engineering scaffold into a bone defect part; the control test was: the tissue engineering scaffold is directly implanted into the bone defect part, and the table 2 is a comparison table of the mechanical experiment results.
TABLE 2 comparison table of mechanics experiment results
As can be seen from Table 2, the tissue engineering scaffold was implanted into the bone defect site more directly after being first ectopically osteogenized for 2 weeks, and the bone formation effect was better at 20 weeks.
Fig. 4a and 4b are diagrams of the in vivo osteogenesis effect of the ectopic osteogenesis scaffold, wherein in a rabbit radius defect model, after the tissue engineering scaffold is firstly ectopically osteogenized in muscles for 2 weeks by applying the device, the tissue engineering scaffold is implanted into a bone defect part again, as shown in fig. 4 a; directly implanting the tissue engineering scaffold into the bone defect site, fig. 4b shows; the tissue engineering scaffold is firstly ectopically osteogenesis for 2 weeks and then is implanted into the bone defect part, so that the tissue engineering scaffold is directly implanted into the bone defect part, and has better osteogenesis effect at 20 weeks.
The utility model provides a pair of dystopy osteogenesis device in auxiliary body for damaged treatment of big section bone, be applicable to the dystopy osteogenesis treatment big section bone defect, a structure is reasonable, design benefit, it is used for setting up the tissue engineering support to set up the opening in the unilateral of cavity, the allogeneic aggregate, be the tissue engineering support in muscle, the placing of subassembly such as allogeneic xenogeneic bone material provides the space, make osteogenesis appearance rule, and be convenient for get the bone operation, the curb plate that forms the cavity simultaneously sets up a plurality of micropores, effectively guaranteed the material exchange, improve the damaged treatment of big section bone, and the device has a better spreading value.
The present invention is not limited to the above embodiments, and any person can obtain other products in various forms without departing from the scope of the present invention, but any change in shape or structure is included in the technical solution that is the same as or similar to the present invention.
Claims (10)
1. An auxiliary in-vivo ectopic osteogenesis device for treating a large bone defect comprises a main body part, wherein the main body part comprises a top plate, a side plate and a bottom plate, the side plate is lapped between the top plate and the bottom plate, the side plate is a member bent towards one side, and the top plate, the side plate and the bottom plate enclose a cavity with a single-side opening; the device of the auxiliary in-vivo ectopic osteogenesis device for treating the large-section bone defect also comprises an infusion tube, wherein the infusion tube is detachably communicated with the cavity to deliver nutrient solution for the formation of ectopic osteogenesis.
2. The device for the treatment of a bone defect of large size according to claim 1, wherein the lateral plate has a cross-sectional shape of a circular portion, and the top plate and the bottom plate are matched such that both ends of the lateral plate are fixed to the outer sides of the top plate and the bottom plate in an overlapping manner.
3. The device for the treatment of a bone defect of large size according to claim 1, wherein the lateral plate has a cross-sectional shape of a part of an ellipse, and the top plate and the bottom plate are matched so that both ends of the lateral plate are fixed to the outer sides of the top plate and the bottom plate in an overlapping manner.
4. The device of claim 1, wherein the top plate, the side plate and the bottom plate are integrally formed to define a cavity with a single side opening.
5. The assisted in vivo ectopic osteogenesis device for the treatment of large bone defects according to claim 1, wherein said side plate has a plurality of micropores for exchanging substances with the outside of said cavity.
6. The assisted in vivo ectopic osteogenesis device for the treatment of large bone defects according to claim 5, wherein said micropores are uniformly formed on the side plate.
7. An assisted in vivo ectopic osteogenesis device for the treatment of large bone defects according to claim 5, wherein said micropores have a cross-sectional area of not more than 0.5mm2。
8. An auxiliary in vivo ectopic osteogenesis device for the treatment of large bone defect according to claim 5, wherein said micropores have any one of circular, elliptical, triangular and rectangular shape.
9. The device of claim 1, wherein the top plate, the side plates and the bottom plate are elastic members.
10. The assisted in vivo ectopic osteogenesis device for the treatment of large bone defect according to claim 9, wherein said top plate, side plate and bottom plate are made of any one of polylactic acid, polylactic acid-glycolic acid copolymer, polycaprolactone, polyglycolic acid and bioglass.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110433011A (en) * | 2019-07-25 | 2019-11-12 | 中国人民解放军总医院 | It is a kind of for large segmental bone defect treatment auxiliary body in ectopic osteogenesis device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110433011A (en) * | 2019-07-25 | 2019-11-12 | 中国人民解放军总医院 | It is a kind of for large segmental bone defect treatment auxiliary body in ectopic osteogenesis device |
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