CN113081379A - Three-dimensional developable hernia repair composite patch and preparation method thereof - Google Patents
Three-dimensional developable hernia repair composite patch and preparation method thereof Download PDFInfo
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- CN113081379A CN113081379A CN202110356257.0A CN202110356257A CN113081379A CN 113081379 A CN113081379 A CN 113081379A CN 202110356257 A CN202110356257 A CN 202110356257A CN 113081379 A CN113081379 A CN 113081379A
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- hernia repair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
- A61F2002/0072—Delivery tools therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Abstract
The invention discloses a three-dimensional developable hernia repair composite patch and a preparation method thereof, and relates to the technical field of medical instruments. The invention is provided with the traction structure, is convenient for placing and adjusting the position of the patch in the operation, and solves the problem that the position and the direction of the patch in the prior art are difficult to adjust after the patch is placed.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a three-dimensional developable hernia repair composite patch and a preparation method thereof.
Background
Hernia refers to the condition that certain tissues or organs in the body leave the normal anatomical position and are higher than that of men, the common and frequent inguinal hernia refers to the condition that organs in the abdominal cavity protrude to the body surface through the defect of the inguinal region to form a mass, and pathogenic factors include congenital anatomical abnormality, acquired weakness or defect of the abdominal wall. The most effective and mainstream treatment for current treatments is tensionless hernia repair, where the weak transverse abdominal fascia is repaired or replaced by a patch material.
Through to the inside pubic muscle pore region dissection research analysis of inguinal region peritoneum front space, human abdominal cavity inguinal region has certain convex-concave radian, traditional inguinal hernia repair operation adopts traditional plane patch to restore, the patch passes through external force fixed back, because its form does not match with the inguinal, the patch position is difficult fixed, operation time overlength, probably lead to patient's postoperative to feel uncomfortable in the activity, the foreign body feels strong, chronic pain even, simultaneously because the patch goes into not good enough with the tissue, take place the shrink and curl, and then form the dead space hydrops, cause a series of complications such as infection. Researches find that the three-dimensional inguinal hernia repair patch which conforms to the physiological form of the inguinal region can well solve the problems. Because the form of the three-dimensional inguinal hernia repair patch can be tightly pasted on abdominal wall tissues, and meanwhile, the form retentivity of the three-dimensional patch is good due to the sealing edge of the patch, the operation time is reduced, the patch is not easy to bend, the foreign body feeling and pain feeling of a patient after operation can be effectively reduced, and meanwhile, the incidence rate of other complications can also be reduced. Therefore, the inguinal hernia repair patch which is designed to conform to the three-dimensional structure of the puborectal region has very important clinical significance.
Disclosure of Invention
The invention aims to provide a three-dimensional developable hernia repair composite patch and a preparation method thereof, which are used for solving the problems in the prior art, are convenient to place and adjust the position of the patch during operation and can observe the shrinkage condition of the patch in a developing way after the operation.
In order to achieve the purpose, the invention provides the following scheme:
the invention provides a three-dimensional developable hernia repair composite patch, which is matched with a human pubococcygeus hole area in shape and comprises a first support layer, a patch layer and a second support layer which are sequentially connected, wherein the patch layer is provided with a development structure, and the first support layer is provided with a traction structure.
Preferably, the first support layer, the patch layer and the second support layer are made of a crystalline or semi-crystalline thermoplastic polymer having a fixed melting point.
Preferably, the first supporting layer and the second supporting layer are hollow polymer films.
Preferably, the first support layer and the second support layer are made of polyvinylidene fluoride or polyethylene terephthalate which is a high polymer material.
Preferably, the patch layer is made of polypropylene, polytetrafluoroethylene, polyvinylidene fluoride, polyester or expanded polytetrafluoroethylene.
Preferably, the developing structure is made of medical stainless steel wires, gold wires, titanium wires, silver wires, polymer composite wires or X-ray opaque developing materials.
Preferably, the development profile of the development structure is circular, square, oval, rectangular or rhombic.
Preferably, the first support layer, the patch layer and the second support layer are all connected by medical glue or medical adhesive.
The invention also provides a preparation method of the three-dimensional developable hernia repair composite patch, which comprises the following steps:
the method comprises the following steps: according to clinical anatomical experimental data of a pubic muscle pore region of a human body, selecting a heat-conducting metal material with excellent performance, and designing and forming a three-dimensional hot-pressing die;
step two: preparing a high polymer material into a primary film by a melt casting method, carrying out biaxial stretching on the primary film, engraving the surface of the stretched primary film by a machine engraving method, and then carrying out flattening and heat setting treatment to obtain a first supporting layer and a second supporting layer;
step three: sequentially connecting and pressing the first support layer, the planar patch layer with the developing structure and the second support layer by medical glue or medical adhesive to form a composite patch;
step four: placing the composite patch obtained in the third step on a laser engraving cutting machine, cutting to obtain a three-dimensional size which accords with a pubic muscle hole area of a human body, then placing the cut composite patch between an upper plate and a lower plate of a hot pressing die, tightly pressing and closing the upper plate and the lower plate, placing the hot pressing die on a flat vulcanizing machine for conducting temperature and pressure, carrying out hot pressing molding on the cut composite patch for a certain time, taking out the composite patch, and rapidly cooling;
step five: weaving the developing material into a patch layer of the composite patch according to a certain shape or contour;
step six: fixing a traction structure on the upper surface of the first support layer;
step seven: and sterilizing, vacuumizing and packaging to obtain the three-dimensional developable hernia repair composite patch.
Compared with the prior art, the invention has the following technical effects:
the invention is provided with the traction structure, is convenient for placing and adjusting the position of the patch in the operation, and solves the problem that the position and the direction of the patch in the prior art are difficult to adjust after the patch is placed.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a schematic view of a three-dimensional developable hernia repair composite patch of the present invention;
FIG. 2 is a schematic view of a hot pressing mold and a three-dimensional developable hernia repair composite patch according to the present invention;
FIG. 3 is a front view of the hot press mold and three-dimensional developable hernia repair composite patch of the present invention;
wherein: the composite patch comprises a 100-three-dimensional developable hernia repair composite patch, 1-a first supporting layer, 2-a patch layer, 3-a second supporting layer, 4-a traction structure, 5-a development structure, 6-a hot-pressing mold, 7-an upper plate and 8-a lower plate.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.
The invention aims to provide a three-dimensional developable hernia repair composite patch and a preparation method thereof, which are used for solving the problems in the prior art, are convenient to place and adjust the position of the patch during operation and can observe the shrinkage condition of the patch in a developing way after the operation.
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in further detail below.
Example one
As shown in fig. 1: the embodiment provides a three-dimensional compound patch 100 of hernia repair that can develop, three-dimensional compound patch 100's of hernia repair shape and human pubococcygeus area phase-match can develop, through 6 hot briquetting of hot pressing mould, three-dimensional compound patch 100 of hernia repair that can develop is including the first supporting layer 1 that connects gradually, patch layer 2 and second supporting layer 3, be provided with development structure 5 on the patch layer 2, patch layer 2 is the net piece structure, development structure 5 is according to certain shape, the profile setting is on patch layer 2, be provided with on the first supporting layer 1 and pull structure 4, it is the traction band to pull structure 4. This embodiment is provided with pulls structure 4, makes things convenient for in the operation to the placing and the adjustment of patch position, has solved the difficult problem of adjusting of position, direction after the patch of prior art is put into, and this embodiment is through setting up development structure 5, makes things convenient for the condition of postoperative detection patch aversion, shrink, relapse and other complications.
Specifically, in the present embodiment, the first support layer 1, the patch layer 2, and the second support layer 3 are made of crystalline or semi-crystalline thermoplastic high polymer having a fixed melting point.
In this embodiment, the first supporting layer 1 and the second supporting layer 3 are both hollow polymer films for increasing the elasticity and the tension of the patch.
In this embodiment, the first support layer 1 and the second support layer 3 are made of one or a mixture of polyvinylidene fluoride and polyethylene terephthalate.
In this embodiment, the patch layer 2 is made of one or a mixture of polypropylene, teflon, polyvinylidene fluoride, polyester, and expanded teflon.
In this embodiment, the developing structure 5 is made of a medical stainless steel wire, a gold wire, a titanium wire, a silver wire, a polymer composite wire, a developable alloy wire, or an X-ray opaque developing material.
In the present embodiment, the development profile of the development structure 5 is a circle, a square, an ellipse, a rectangle, or a rhombus.
In this embodiment, the first support layer 1, the patch layer 2 and the second support layer 3 are all connected by medical glue or medical adhesive.
The three-dimensional developable hernia repair composite patch 100 of the embodiment has good elasticity and tension, is stable in shape, is easy to place and adjust, and can be used for observing the shrinking condition of the patch after operation.
Example two
As shown in fig. 2-3: the embodiment provides a method for preparing a three-dimensional developable hernia repair composite patch 100 according to the first embodiment, which comprises the following steps:
the method comprises the following steps: according to clinical anatomical experimental data of a pubococcygeus region of a human body, a heat-conducting metal material with excellent performance is selected, and a three-dimensional hot-pressing die 6 is designed and molded, wherein the hot-pressing die 6 is easy to operate and has a specific size and radian;
step two: preparing a high polymer material into a primary film by a melt casting method, carrying out bidirectional stretching on the primary film, carving holes on the surface of the stretched primary film by a machine carving method, and then carrying out flattening and heat setting treatment to obtain a first supporting layer 1 and a second supporting layer 3;
step three: sequentially connecting and pressing the first supporting layer 1, the plane patch layer 2 with the developing structure 5 and the second supporting layer 3 by medical glue or medical adhesive to form a composite patch;
step four: placing the composite patch obtained in the third step on a laser engraving cutting machine, cutting to obtain a three-dimensional size which accords with a pubic muscle hole area of a human body, then placing the cut composite patch between an upper plate 7 and a lower plate 8 of a hot pressing die 6, tightly pressing and closing the upper plate 7 and the lower plate 8, placing the hot pressing die 6 on a flat vulcanizing machine for conducting temperature and pressure, carrying out hot pressing molding on the cut composite patch for a certain time, taking out the composite patch, and rapidly cooling;
step five: weaving the developing material into a patch layer 2 of the composite patch according to a certain shape or outline;
step six: fixing the traction structure 4 on the upper surface of the first support layer 1 by adopting a bonding, welding, weaving or sewing method;
step seven: after sterilization and vacuum-pumping packaging, the three-dimensional developable hernia repair composite patch 100 is obtained.
The principle and the implementation mode of the present invention are explained by applying specific examples in the present specification, and the above descriptions of the examples are only used to help understanding the method and the core idea of the present invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, the specific embodiments and the application range may be changed. In view of the above, the present disclosure should not be construed as limiting the invention.
Claims (9)
1. The three-dimensional developable hernia repair composite patch is characterized in that: the shape and the human pubococcygeus area phase-match of three-dimensional developable hernia repair composite patch, three-dimensional developable hernia repair composite patch is including the first supporting layer, patch layer and the second supporting layer that connect gradually, be provided with the development structure on the patch layer, be provided with on the first supporting layer and pull the structure.
2. The three-dimensional developable hernia repair composite patch according to claim 1, wherein: the first support layer, the patch layer and the second support layer are all made of crystalline or semi-crystalline thermoplastic polymers with fixed melting points.
3. The three-dimensional developable hernia repair composite patch according to claim 1, wherein: the first supporting layer and the second supporting layer are hollow polymer films.
4. The three-dimensional developable hernia repair composite patch according to claim 3, wherein: the first supporting layer and the second supporting layer are made of high polymer materials of polyvinylidene fluoride or poly (hexamethylene terephthalate).
5. The three-dimensional developable hernia repair composite patch according to claim 1, wherein: the patch layer is made of polypropylene, polytetrafluoroethylene, polyvinylidene fluoride, polyester or expanded polytetrafluoroethylene.
6. The three-dimensional developable hernia repair composite patch according to claim 1, wherein: the developing structure is made of medical stainless steel wires, gold yellow wires, titanium wires, silver wires, polymer composite wires or X-ray opaque developing materials.
7. The three-dimensional developable hernia repair composite patch according to claim 1, wherein: the developing outline of the developing structure is round, square, oval, rectangular or rhombic.
8. The three-dimensional developable hernia repair composite patch according to claim 1, wherein: the first supporting layer, the patch layer and the second supporting layer are all connected through medical glue or medical adhesive.
9. A method of manufacturing a three-dimensional developable hernia repair composite patch according to any one of claims 1-8, comprising: the method comprises the following steps:
the method comprises the following steps: according to clinical anatomical experimental data of a pubic muscle pore region of a human body, selecting a heat-conducting metal material with excellent performance, and designing and forming a three-dimensional hot-pressing die;
step two: preparing a high polymer material into a primary film by a melt casting method, carrying out biaxial stretching on the primary film, engraving the surface of the stretched primary film by a machine engraving method, and then carrying out flattening and heat setting treatment to obtain a first supporting layer and a second supporting layer;
step three: sequentially connecting and pressing the first support layer, the planar patch layer with the developing structure and the second support layer by medical glue or medical adhesive to form a composite patch;
step four: placing the composite patch obtained in the third step on a laser engraving cutting machine, cutting to obtain a three-dimensional size which accords with a pubic muscle hole area of a human body, then placing the cut composite patch between an upper plate and a lower plate of a hot pressing die, tightly pressing and closing the upper plate and the lower plate, placing the hot pressing die on a flat vulcanizing machine for conducting temperature and pressure, carrying out hot pressing molding on the cut composite patch for a certain time, taking out the composite patch, and rapidly cooling;
step five: weaving the developing material into a patch layer of the composite patch according to a certain shape or contour;
step six: fixing a traction structure on the upper surface of the first support layer;
step seven: and sterilizing, vacuumizing and packaging to obtain the three-dimensional developable hernia repair composite patch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110356257.0A CN113081379A (en) | 2021-04-01 | 2021-04-01 | Three-dimensional developable hernia repair composite patch and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110356257.0A CN113081379A (en) | 2021-04-01 | 2021-04-01 | Three-dimensional developable hernia repair composite patch and preparation method thereof |
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| CN113081379A true CN113081379A (en) | 2021-07-09 |
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| CN202110356257.0A Pending CN113081379A (en) | 2021-04-01 | 2021-04-01 | Three-dimensional developable hernia repair composite patch and preparation method thereof |
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| CN203122677U (en) * | 2012-12-29 | 2013-08-14 | 上海索康医用材料有限公司 | Hernia repair piece |
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| US20190117362A1 (en) * | 2017-10-20 | 2019-04-25 | Lifecell Corporation | Tissue products with variations in mechanical properties and methods of treatment |
| CN109771085A (en) * | 2019-01-14 | 2019-05-21 | 东华大学 | A kind of three-dimensional hernia reparation sticking patch and preparation method thereof with anti-edge-rolling |
| CN209574958U (en) * | 2018-12-29 | 2019-11-05 | 上海索康医用材料有限公司 | A kind of high intensity surgical patch |
| CN110613529A (en) * | 2019-10-14 | 2019-12-27 | 江苏盛纳凯尔医用科技有限公司 | Developable patch and preparation method thereof |
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2021
- 2021-04-01 CN CN202110356257.0A patent/CN113081379A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102316823A (en) * | 2009-02-11 | 2012-01-11 | 新加坡南洋理工大学 | Multi-layered surgical prosthesis |
| US20110144667A1 (en) * | 2009-09-08 | 2011-06-16 | Anthony Richard Horton | Hernia patch |
| CN201879863U (en) * | 2010-11-14 | 2011-06-29 | 薛运章 | Original-shaped mesh patch for inguinal herniorrhaphy |
| CN102908676A (en) * | 2012-10-19 | 2013-02-06 | 东华大学 | Hollowed PP/PVDF (Polypropylene/Polyvinylidene Fluoride) composite hernia sticking patch and preparation method thereof |
| CN102920528A (en) * | 2012-10-19 | 2013-02-13 | 东华大学 | Hollowed-out membrane used as hernia patch and preparation method thereof |
| CN203122677U (en) * | 2012-12-29 | 2013-08-14 | 上海索康医用材料有限公司 | Hernia repair piece |
| US20190117362A1 (en) * | 2017-10-20 | 2019-04-25 | Lifecell Corporation | Tissue products with variations in mechanical properties and methods of treatment |
| CN208525130U (en) * | 2017-11-22 | 2019-02-22 | 捷润(上海)医疗科技有限公司 | A kind of double sandwich structure hernia paster |
| CN208611413U (en) * | 2017-11-27 | 2019-03-19 | 上海索康医用材料有限公司 | A kind of medical high-strength degree eptfe membrane flake products |
| CN209574958U (en) * | 2018-12-29 | 2019-11-05 | 上海索康医用材料有限公司 | A kind of high intensity surgical patch |
| CN109771085A (en) * | 2019-01-14 | 2019-05-21 | 东华大学 | A kind of three-dimensional hernia reparation sticking patch and preparation method thereof with anti-edge-rolling |
| CN110613529A (en) * | 2019-10-14 | 2019-12-27 | 江苏盛纳凯尔医用科技有限公司 | Developable patch and preparation method thereof |
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Application publication date: 20210709 |