CN108295326A - A kind of ultrapure haemodialyser of two-chamber - Google Patents
A kind of ultrapure haemodialyser of two-chamber Download PDFInfo
- Publication number
- CN108295326A CN108295326A CN201810120837.8A CN201810120837A CN108295326A CN 108295326 A CN108295326 A CN 108295326A CN 201810120837 A CN201810120837 A CN 201810120837A CN 108295326 A CN108295326 A CN 108295326A
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- CN
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- Prior art keywords
- dialyzate
- cavity
- haemodialysis
- ultrapure
- hollow
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1623—Disposition or location of membranes relative to fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
Abstract
The invention discloses a kind of ultrapure haemodialysers of two-chamber, belong to the field of medical instrument technology, a kind of ultrapure haemodialyser of two-chamber is made of two-chamber shell, dialyzate entrance, dialyzate outlet, blood inlet end lid, bleeding end cap, sealing ring, fluid sealant, haemodialysis hollow-fibre membrane, dialyzate purification with hollow-fibre membrane or adsorbing sphere.Wherein two-chamber shell is composed in parallel by haemodialysis cavity and dialyzate purification cavity, is installed haemodialysis hollow-fibre membrane in haemodialysis cavity additional, is used for haemodialysis；It installs dialyzate purification hollow-fibre membrane or adsorbing sphere in dialyzate purify cavity body additional, for being purified to dialyzate, so that dialyzate is reached the standard of ultrapure hemodialysis, to improve dialysis treatment quality.
Description
Technical field
The present invention relates to a kind of ultrapure haemodialyser of two-chamber, which can be to saturating in clinical treatment kidney trouble
Analysis liquid is filtered and carries out ultrapure diafiltration treatment to blood, belongs to the field of medical instrument technology.
Background technology
Haemodialysis is mainly used for treating the illnesss such as chronic renal failure, acute renal failure and drug poisoning, in clinic
On be widely applied.Blood haemodialysis is the principle using semi-permeable membrane, and blood samples of patients and dialyzate are introduced dialysis simultaneously
Device is in opposite direction flowing in dialysis membrane both sides, relies on solubility gradient, osmotic gradient and the hydraulic pressure gradient of semi-permeable membrane both sides.Pass through
Toxin is removed in disperse, convection current, absorption；Moisture extra in vivo is removed by ultrafiltration and infiltration；The substance for supplementing needs simultaneously, entangles
Positive electrolyte, disturbance of acid-base balance.In blood dialysis, need to use dialysis machine, dialyzer, dialyzate, pipeline of dialysing
Equal related equipments.Wherein, dialyzate carries out mass exchange by dialyzer membrane and blood samples of patients, and blood is exposed to a large amount of dialysis
In liquid, the occurrence and development of the acute and chronic complication of the purity of dialyzate, especially microbiological purity and dialysis patient are closely related.
In the prior art, common mass of dialysate standard requires bacterium<100CFU/ml, endotoxin<0.25EU/ml；The U.S.
AAMI requires bacterium to ultrapure mass of dialysate standard<0.1CFU/ml, endotoxin<0.03EU/ml；The ultrapure dialysis JSDT of Japan
Standard requires bacterium<0.1CFU/ml, endotoxin<0.001EU/ml.Ultrapure dialysis is carried out, the inflammatory reaction incidence of patient is mended
Body activity ratio, leucocyte rate of descent can be reduced；The erythropoietin usage amount and anti-inflammatory drug usage amount of patient all can simultaneously
It is lower, mitigate patient's angiocarpy burden, reduce complication, improves patients ' life quality and the existence time limit.Ultrapure dialysis is existing
It is being widely accepted as a kind of new standard regimens.And to the preparation of ultrapure dialyzate, primary solutions are logical at present
It crosses the installation filter between the dialyzate circulation line of dialysis machine to be filtered, then the dialyzate of filtration is passed through into Pipeline transport
It is treated to haemodialyser.This scheme can not prevent the risk of pipeline pollution after filter completely.
Invention content
The purpose of the present invention is to provide a kind of ultrapure haemodialysers of two-chamber, existing ultrapure dialysis is aimed to solve the problem that
In technology, dialyzate enters the defect being potentially contaminated before dialyzer.
In order to solve the above-mentioned technical problem, the present invention adopts the following technical scheme that：
A kind of ultrapure haemodialyser of two-chamber, which is characterized in that it include two-chamber shell, dialyzate entrance, dialyzate outlet, into
Blood end cap, bleeding end cap, sealing ring, fluid sealant, haemodialysis hollow-fibre membrane, dialyzate purification hollow-fibre membrane or suction
Attached ball.
The two-chamber shell is composed in parallel by haemodialysis cavity and dialyzate purification cavity, and haemodialysis cavity is column
Shape, one end are blood inlet end, and one end is bleeding end, and dialyzate purifies cavity rigidity or flexible connection in haemodialysis chamber dialyzate
Liquid feeding end.
The dialyzate entrance is located at the external side of dialyzate purify cavity.
The dialyzate outlet is located on the outside of haemodialysis cavity blood inlet end.
The blood inlet end lid is installed on haemodialysis cavity blood inlet end.
The bleeding end cap is installed on haemodialysis cavity bleeding end.
The sealing ring is placed in blood inlet end lid, bleeding end cap and haemodialysis cavity junction and dialyzate purification
Cavity and dialyzate entrance pipe junction, are used for waterway seal.
The haemodialysis hollow-fibre membrane is fixed on by sealing glue sticking both ends, filling in haemodialysis cavity
Portion.
The dialyzate purification hollow-fibre membrane or adsorbing sphere, filling are fixed on dialyzate purification inside cavity, can be set
It sets one group, two groups or multigroup filter core reaches multi-filtering Redundancy Design.
The dialyzate purification is polyether sulfone or polysulfones with doughnut membrane material, and internal diameter is 100 μm~250 μm,
Wall thickness is 20 μm~60 μm, and film surface micro-pore diameter is 0.5nm~10nm, amounts to membrane area 0.3m2~5m2。
The adsorbing sphere material is activated carbon or absorption resin, and aperture 1nm-40nm specific surface areas are 600-1200m2/
g。
Patent of the present invention using when be installed in haemodialysis control unit, when being treated blood samples of patients by piping connection into blood
End cap flows through haemodialysis hollow-fibre membrane, then outflows back to patient's body from bleeding end cap.It has been configured by dialysis machine saturating
Analysis liquid enters dialyzate from dialyzate entrance and purifies cavity, via dialyzate purification hollow-fibre membrane or adsorbing sphere filtering absorption
Haemodialysis cavity is flowed into afterwards, and carrying out cross-film with blood samples of patients contacts, and toxin is removed by disperse, convection current, absorption；Pass through ultrafiltration
Extra moisture is removed with infiltration；The substance needed is supplemented for patient simultaneously, corrects electrolyte, disturbance of acid-base balance；Completion is controlled
The dialyzate for the treatment of is exported from dialyzate again to flow out.
Compared to existing haemodialyser and ultrapure dialysis solution, the invention has the advantages that：
Dialyzate purification cavity is directly mounted at haemodialyser feed liquor front end by the present invention, and centre, can without extra piping connection
Exclude the pipeline pollution risk between conventional hemodialysis device and dialysis machine；
The dialyzate purification hollow-fibre membrane or adsorbing sphere of the present invention, can filter and adsorb most endotoxin molecules, protect
Water quality reaches ultrapure haemodialysis water supply standard after barrier filtering, promotes dialysis treatment quality；
Multi-filtering and adsorption design, the Redundancy Design of multi-filtering absorption can be used to ensure that the reliable of filter effect for the present invention
Property；
Haemodialyser and dialysate filter device integrated design are easily installed operation by the present invention, mitigate the ultrapure dialysis of tradition
The attended operation cost of scheme.
Description of the drawings
Using attached drawing, the invention will be further described, but the content in attached drawing does not constitute any limitation of the invention.
Fig. 1 is a kind of structural schematic diagram of the present invention；
Reference numeral is：
101 be the haemodialysis cavity of two-chamber shell；
102 purify cavity for the dialyzate of two-chamber shell；
201 be dialyzate entrance；
202 export for dialyzate；
301 be blood inlet end lid；
302 be bleeding end cap；
401,402 be sealing ring；
501,502,503 be fluid sealant；
601 be haemodialysis hollow-fibre membrane；
602 be dialyzate purification hollow-fibre membrane.
Specific implementation mode
Below in conjunction with the drawings and the specific embodiments, the invention will be further described.
Embodiment 1
A kind of ultrapure haemodialyser of two-chamber, as shown in Figure 1, two-chamber shell 101,102 is equipped with, wherein 101 be haemodialysis chamber
Body, 102 purify cavity for dialyzate；Dialyzate entrance 201；Dialyzate outlet 202；Blood inlet end lid 301；Bleeding end cap 302；It is close
Seal 401,402；Fluid sealant 501,502,503；Haemodialysis hollow-fibre membrane 601,；Dialyzate purification hollow-fibre membrane
602。
Dialyzate purification cavity 102 is external on the outside of 101 bleeding end of haemodialysis cavity；Dialyzate entrance 201 is located at saturating
102 outside of liquid purification cavity is analysed, dialyzate outlet 202 is located on the outside of 101 blood inlet end of haemodialysis cavity；Blood inlet end lid 301, goes out
The blood inlet end for being screwed to haemodialysis cavity 101 and bleeding end is respectively adopted in blood end cap 302；Sealing ring 401,402 is distinguished
It is sleeved on the junction of each cavity and end cap or interface, is sealed for fluid path；Fluid sealant 501,502 is for using haemodialysis
601 fixing seal of hollow-fibre membrane is inside haemodialysis cavity 101；Fluid sealant 503 is used to dialyzate purifying hollow fibre
Film fixing seal is tieed up inside dialyzate purification cavity 102；Dialyzate purification is polyether sulfone with doughnut membrane material or gathers
Sulfone internal diameter is 100 μm~250 μm, and wall thickness is 20 μm~60 μm, and film surface micro-pore diameter is 0.5nm~10nm, amounts to film surface
Product 0.3m2~5m2。
In actual use, which need to be held on haemodialysis control unit.Blood samples of patients is by haemodialysis control unit from into blood
End cap 301 is pumped into haemodialysis cavity 101, passes through out of haemodialysis hollow-fibre membrane 601 film, then from bleeding end cap
302 outflow back to patient's body.The dialyzate prepared enters dialyzate from dialyzate entrance 201 and purifies cavity 102, by saturating
It analyses liquid purification and completes filtering with hollow-fibre membrane 602.Filtered dialyzate enters haemodialysis cavity 101, from haemodialysis
It is flowed through with outside the film of hollow-fibre membrane 601, carrying out cross-film with patient's blood in film contacts, and poison is removed by disperse, convection current, absorption
Element；Extra moisture is removed by ultrafiltration and infiltration；The substance needed is supplemented for patient simultaneously, corrects electrolyte, acid-base balance
It is disorderly；The dialyzate for the treatment of is completed again from 202 outflow of dialyzate outlet.
Embodiment 2
A kind of ultrapure haemodialyser of two-chamber can abandon screw thread and sealing ring coordinates the mode being sealed in embodiment 1,
Using the technique of ultrasonic bond by blood inlet end lid 301,302 fixing seal of bleeding end cap is net by dialyzate in haemodialysis cavity 101
Change 102 fixing seal of cavity in dialyzate entrance 201.
Embodiment 3
A kind of ultrapure haemodialyser of two-chamber, in embodiment 1, dialyzate filter hollow-fibre membrane and single synnema beam can be used,
Dialyzate enters dialyzate purification cavity 102 via dialyzate entrance 201 when use, flows into dialyzate purification hollow-fibre membrane
In 602, then it is forced out outside film and completes to filter, enter back into haemodialysis cavity 101.
Embodiment 4
A kind of ultrapure haemodialyser of two-chamber, can also after dialyzate enters dialyzate purification cavity 102 in embodiment 1,3
It is filtered from dialyzate purification with completion in film is pressed into outside 602 film of hollow-fibre membrane, then flows into haemodialysis cavity 101.
Embodiment 5
A kind of ultrapure haemodialyser of two-chamber, in embodiment 1,3 beams or more can be used with hollow-fibre membrane in dialyzate purification
Tow increases membrane area and filtering times, to cope with the poor environment of mass of dialysate, multi-filtering is needed to ensure filtering effect
Fruit.
Embodiment 6
A kind of ultrapure haemodialyser of two-chamber, in embodiment 1, dialyzate purification can be replaced with hollow-fibre membrane using adsorbing sphere
Generation, adsorbing sphere material are activated carbon or absorption resin, and aperture 1nm-40nm specific surface areas are 600-1200m2/g。
Embodiment 7
A kind of ultrapure haemodialyser of two-chamber, in embodiment 1, dialyzate, which purifies, can be used in cavity 102 in dialyzate filtration
Empty fiber membrane and adsorbing sphere combination.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than is protected to the present invention
The limitation of range, although being explained in detail to the present invention with reference to preferred embodiment, those skilled in the art should manage
Solution, technical scheme of the present invention can be modified or replaced equivalently, without departing from technical solution of the present invention essence and
Range.
Claims (11)
1. a kind of ultrapure haemodialyser of two-chamber is equipped with two-chamber shell, dialyzate entrance, dialyzate outlet, blood inlet end lid, bleeding
End cap, sealing ring, fluid sealant, haemodialysis hollow-fibre membrane, dialyzate purification hollow-fibre membrane or adsorbing sphere, feature
It is：The two-chamber shell mechanism is divided into haemodialysis cavity and dialyzate purification cavity, and dialyzate enters haemodialysis cavity
Preceding elder generation by dialyzate purification cavity be filtered, adsorption cleaning.
2. the ultrapure haemodialyser of a kind of two-chamber according to claim 1, it is characterised in that：The dialyzate of the two-chamber shell
Cavity is purified by rigidity or flexible connection in the dialyzate liquid feeding end of haemodialysis cavity.
3. the ultrapure haemodialyser of a kind of two-chamber according to claim 1, it is characterised in that：Its dialyzate entrance is set to
The outside of liquid purification cavity is analysed, dialyzate outlet is set on the outside of haemodialysis cavity blood inlet end.
4. the ultrapure haemodialyser of a kind of two-chamber according to claim 1, it is characterised in that：Its blood inlet end lid is installed on blood
Dialysis cavity blood inlet end, bleeding end cap are installed on haemodialysis cavity bleeding end.
5. blood inlet end lid according to claim 4, it is characterised in that：Into blood interface perpendicular to dialyzer cavity.
6. the ultrapure haemodialyser of a kind of two-chamber according to claim 1, it is characterised in that：The sealing ring is placed in into blood
End cap, bleeding end cap and haemodialysis cavity junction are used for waterway seal.
7. the ultrapure haemodialyser of a kind of two-chamber according to claim 1, it is characterised in that：The hollow fibre of the haemodialysis
It ties up film and is fixed on haemodialysis inside cavity by sealing glue sticking both ends, filling.
8. the ultrapure haemodialyser of a kind of two-chamber according to claim 1, it is characterised in that：In the dialyzate purification cavity
Fill dialyzate purification hollow-fibre membrane or adsorbing sphere.
9. dialyzate purifies cavity according to claim 8, one group, two groups can be arranged or multigroup filter core reaches multi-filtering
Redundancy Design.
10. according to claim 8 dialyzate purify hollow-fibre membrane, material be polyether sulfone or polysulfones, internal diameter be for
100 μm~250 μm, wall thickness is 20 μm~60 μm, and film surface micro-pore diameter is 0.5nm~10nm, amounts to membrane area 0.3m2~
5m2。
11. adsorbing sphere according to claim 8, material is that activated carbon or absorption resin, aperture 1nm-40nm compare table
Area is 600-1200m2/g。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810120837.8A CN108295326B (en) | 2018-02-09 | 2018-02-09 | Double-cavity ultrapure hemodialyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810120837.8A CN108295326B (en) | 2018-02-09 | 2018-02-09 | Double-cavity ultrapure hemodialyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108295326A true CN108295326A (en) | 2018-07-20 |
| CN108295326B CN108295326B (en) | 2021-03-26 |
Family
ID=62864593
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810120837.8A Active CN108295326B (en) | 2018-02-09 | 2018-02-09 | Double-cavity ultrapure hemodialyzer |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109999243A (en) * | 2019-05-07 | 2019-07-12 | 于秀莲 | A kind of ultrapure haemodialyser of two-chamber |
| CN111202880A (en) * | 2020-02-03 | 2020-05-29 | 深圳汉诺医疗科技有限公司 | Purifying column, device and method for purifying blood |
| CN111905173A (en) * | 2020-08-29 | 2020-11-10 | 江西三鑫医疗科技股份有限公司 | Double-chamber blood filter |
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|---|---|
| CN108295326B (en) | 2021-03-26 |
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