CN109758630A - A kind of absorption type haemodialyser - Google Patents
A kind of absorption type haemodialyser Download PDFInfo
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- CN109758630A CN109758630A CN201910073122.6A CN201910073122A CN109758630A CN 109758630 A CN109758630 A CN 109758630A CN 201910073122 A CN201910073122 A CN 201910073122A CN 109758630 A CN109758630 A CN 109758630A
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- cavity
- blood
- haemodialysis
- hollow
- absorption type
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Abstract
The invention patent discloses a kind of absorption type haemodialyser, belongs to the field of medical instrument technology.A kind of absorption type haemodialyser is made of Blood index cavity, haemodialysis cavity, feed liquor end cap, outlet end lid, sealant, hollow-fibre membrane, adsorbent.Its main body is that Blood index cavity and haemodialysis cavity are composed in series；Feed liquor end cap and outlet end lid are fixed on upper and lower ends；Hollow-fibre membrane tow is adhered to haemodialysis inside cavity by sealant；Adsorbent is hollow adsorption filament, is bonded and fixed in Blood index cavity with sealant.The invention patent using when be installed in dialysis machine, access blood samples of patients and dialyzate, blood samples of patients first adsorbs harmful macromolecular substances via Blood index cavity, and fluid infusion is administered on demand, enters back into haemodialysis cavity and carries out dialysis treatment.
Description
Technical field
The present invention relates to a kind of absorption type haemodialyser, which can be to blood in clinical treatment kidney trouble
Big molecular impurity in perfusion absorption nocuousness is carried out, while carrying out hemodialysis, belongs to the field of medical instrument technology.
Background technique
Haemodialysis is mainly used for treating the illnesss such as chronic renal failure, acute renal failure and drug poisoning, in clinic
On be widely applied.Haemodialysis is the principle using semi-permeable membrane, and blood samples of patients and dialyzate are introduced dialyzer simultaneously,
It is in opposite direction flowing in dialysis membrane two sides, by solubility gradient, osmotic gradient and the hydraulic pressure gradient of semi-permeable membrane two sides.By more
It dissipates, convection current, absorption removing toxin；Moisture extra in vivo is removed by ultrafiltration and infiltration；The substance of needs is supplemented simultaneously, is corrected
Electrolyte, disturbance of acid-base balance.
In the prior art, conventional hemodialysis treat used in dialyzer, fenestra is between 1nm-15nm, high pass at present
Dialyzer molecule interception is measured up to 60000, membrane permeability cannot increase again, and otherwise the substances such as albumin can be saturating in blood
Out.Such dialysis treatment, which can only filter, removes blood samples of patients small molecule toxins, cannot remove in, macromolecular and protein binding class
Toxin.
In order to which in removing, macromolecular toxins patient needs periodically do blood perfusion again.Blood perfusion, mainly by perfusion device
Adsorbent adsorb blood in, macromolecular poisonous substance, drug, metabolite, reach purification blood purpose.But adsorbent is very difficult to
Except urea, phosphate, moisture and electrolyte, needs to be combined with haemodialysis and complete treatment.
It is at present two to arrive haemodialysis three times, every two to four Monday weekly to the general treatment mode of patients with chronic renal failure
Secondary blood perfusion.It is combined when carrying out blood perfusion with haemodialysis, the perfusion for first carrying out 2 hours adds dialysis, then removes filling
It flows device and carries out blood back, then individually continue haemodialysis 2 hours, during which configure the pre- fliud flushing of perfusion, pre- to rush, the operation such as blood back ten
Divide many and diverse.Meanwhile this treatment mode means in patient's body, the toxin of macromolecular needs two could pass through perfusion to surrounding
It is once removed, the siltation time is longer, and each perfusion removing pressure is larger, and other organs cardiovascular to patient cause larger
Burden, complication rate is higher, and patients ' life quality decline may cause time-to-live reduction.
Summary of the invention
The purpose of the present invention is to provide a kind of absorption type haemodialysers, aim to solve the problem that existing haemodialysis and filling
In Flow Technique, middle macromolecular toxins cycle of removing is too long, the excessively complicated disadvantage of operation.
In order to solve the above-mentioned technical problem, the present invention adopts the following technical scheme:
A kind of absorption type haemodialyser, which is characterized in that it includes Blood index cavity, haemodialysis cavity, feed liquor
End cap, outlet end lid, sealant, hollow-fibre membrane, adsorbent.Its main body is connected by Blood index cavity and haemodialysis cavity
Composition.
The feed liquor end cap is fixed on Blood index cavity upper surface, and fluid infusion, Blood index cavity side are arranged on end cap
Blood inlet is arranged in face.
The outlet end is placed on haemodialysis cavity lower end surface, and blood outlet, haemodialysis cavity side are arranged on end cap
Dialyzate inlet and liquid outlet are set.
The feed liquor end cap, outlet end lid are screw threads for fastening connection, Nian Jie or weldering with dialyzer main cavity connection type
It connects.
The adsorbent is placed in Blood index cavity, and material is hollow adsorption filament；Hollow adsorption filament inflection at U-shaped,
Open end towards end cap fluid infusion, and by the sealant encapsulation be fixed in Blood index cavity.
For the hollow-fibre membrane with the sealant adhering and sealing in haemodialysis inside cavity, film wire beam internal diameter is 150 μ
M~250 μm, wall thickness are 25 μm~60 μm, and film surface micro-pore diameter is 1nm~15nm, amount to membrane area 0.5m2~5m2。
The invention patent using when be installed in haemodialysis control unit, blood samples of patients is by piping connection into blood when being treated
Mouthful, into Blood index cavity, when blood flows through adsorbent, in blood plasma in, macromolecular toxins can be adsorbed the micro- of agent surface
Pore structure selective absorption is to remove.In therapeutic process, it can also be injected on demand by treatment medicament and fluid infusion by fluid infusion
In empty adsorption filament, enter blood samples of patients after filtering by adsorption filament surface micropore.
After adsorbing therapy by Blood index cavity, blood enters the hollow-fibre membrane in haemodialysis cavity, with
The dialyzate flowed through outside film carries out cross-film contact, by disperse, convection current, adsorbs in removing, small molecule toxins；Pass through ultrafiltration and infiltration
Extra moisture is removed thoroughly；The substance needed is supplemented for patient simultaneously, corrects electrolyte, disturbance of acid-base balance.Complete treatment
Blood outflows back to patient's body from outlet end lid again.
Compared to existing haemodialysis and blood perfusion solution, the present invention has the following advantages:
The present invention connects haemodialysis cavity and Blood index cavity, and it is big that single therapy can remove simultaneously patient's body
The toxin of small molecular amount.
Fluid infusion and medicament can also be added as adsorbent in empty adsorption filament to the present invention on demand over the course for the treatment of in use,
Blood samples of patients is imported after being filtered.
The present invention can increase in blood samples of patients, the removing frequency of macromolecular toxins, follow arrive within haemodialysis frequency one week two
Three times, it reduces patient's body toxin to deposit the time, mitigates the burden of patient's angiocarpy and other organs, it is several to reduce complication generation
Rate.
Invention increases macromoleculars in blood to remove the treatment frequency, can be reduced single noxious material adsorption pressure accordingly
Power, clearance rate is promoted, while reducing single use adsorbent amount, reduces cavity blood room volume, cardiopulmonary bypass in patients blood body
Product is reduced, and mitigates patient's pressure cvd.
Integrated design of the present invention, the simplified operation step in treatment, reduces consumptive material dosage, mitigates doctors and patients' burden.
Detailed description of the invention
The present invention will be further described with reference to the accompanying drawings, but the content in attached drawing does not constitute any limitation of the invention.
Fig. 1 is a kind of structural schematic diagram of the invention, appended drawing reference are as follows:
101 feed liquor end caps；
102 Blood index cavitys；
103 haemodialysis cavitys；
104 outlet end lids；
105 hollow adsorption filaments；
106 hollow-fibre membranes:
107 fluid infusions；
108 blood inlets；
The outlet of 109 dialyzates；
110 dialyzate entrances；
111 blood outlets；
112,113,114 sealants.
Specific embodiment
Below in conjunction with the drawings and the specific embodiments, the invention will be further described.
Embodiment 1
A kind of absorption type haemodialyser, as shown in Figure 1, being equipped with feed liquor end cap 101, Blood index cavity 102, blood is saturating
Analyse cavity 103, outlet end lid 104, hollow adsorption filament 105, hollow-fibre membrane 106, sealant 112,113,114.Its main body by
Blood index cavity 102 and haemodialysis cavity 103 are composed in series.
The feed liquor end cap 101 is placed in 102 upper surface of Blood index cavity, there is fluid infusion 107, Blood index chamber on end cap
102 side of body is provided with blood inlet 108.
The outlet end lid 104 is placed in 103 lower end surface of haemodialysis cavity.
The hollow adsorption filament 105, is folded into U-shaped, is placed in Blood index cavity 102, and tow opening is towards fluid infusion
107, with 112 fixing seal of sealant.Its surface micropore diameter is 1nm~40nm, and specific surface area is 300~1500m2/g。
The hollow-fibre membrane 106 with 113,114 adhering and sealing of sealant inside haemodialysis cavity 103, film
Tow internal diameter is 150 μm~250 μm, and wall thickness is 25 μm~60 μm, and film surface micro-pore diameter is 1nm~15nm, amounts to membrane area
0.5m2~5m2。
The invention patent using when be installed in haemodialysis control unit, blood samples of patients is by piping connection to blood when being treated
Entrance 108, into Blood index cavity 102, when blood flows through hollow adsorption filament 105, in blood plasma in, macromolecular toxins can quilt
The microcellular structure selective absorption on hollow adsorption filament surface is to remove.Over the course for the treatment of, administration and fluid infusion are needed, can be connected
To fluid infusion 107, by the injection of required solution by entering blood samples of patients after the filtering of its surface micropore in hollow adsorption filament.
After adsorbing therapy by Blood index cavity, blood enters hollow-fibre membrane 106, and dialyzate enters from dialyzate
Mouth 110 enters haemodialysis cavity 103, and blood carries out cross-film with the dialyzate flowed through outside film and contacts, and passes through disperse, convection current, suction
In attached removing, small molecule toxins；Extra moisture is removed by ultrafiltration and infiltration；The substance needed is supplemented for patient simultaneously, is entangled
Positive electrolyte, disturbance of acid-base balance；The blood for completing treatment is flowed out from blood outlet 111 again, returns to patient's body, dialyzate waste liquid
Then from 109 discharge of dialyzate outlet.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should be managed
Solution, can with modification or equivalent replacement of the technical solution of the present invention are made, without departing from technical solution of the present invention essence and
Range.
Claims (6)
1. a kind of absorption type haemodialyser, it is equipped with Blood index cavity, haemodialysis cavity, feed liquor end cap, outlet end lid, close
Sealing, hollow-fibre membrane, adsorbent；
It is characterized by: connecting a Blood index cavity in haemodialysis cavity one end.
2. a kind of absorption type haemodialyser according to claim 1, it is characterised in that: the feed liquor end cap and outlet end lid
It is placed in Blood index cavity and haemodialysis cavity outer end；The feed liquor end cap and outlet end lid connect with cavity screw threads for fastening,
It is bonded or welded.
3. a kind of absorption type haemodialyser according to claim 1, it is characterised in that: blood inlet is arranged in cavity liquid feeding end
And fluid infusion；In cavity outlet end, blood outlet is set；Dialyzate inlet is set in haemodialysis cavity side and dialyzate goes out
Liquid mouth.
4. a kind of absorption type haemodialyser according to claim 1, it is characterised in that: adsorbent is placed in Blood index cavity
Interior, material is hollow adsorption filament；Hollow adsorption filament is a branch of and inflection at U-shaped, and tow open end is towards the feed liquor end cap；In
Empty adsorption filament is using the sealant fixing seal in the Blood index inside cavity.
5. hollow adsorption filament according to claim 4, surface micropore diameter is 1nm~40nm, specific surface area is 300~
1500m2/g。
6. a kind of absorption type haemodialyser according to claim 1, it is characterised in that: the sealing of its hollow-fibre membrane
Glue sticking is sealed in haemodialysis inside cavity；Tow internal diameter is 150 μm~250 μm, and wall thickness is 25 μm~60 μm, and film surface is micro-
Bore dia is 1nm~15nm, amounts to membrane area 0.5m2~5m2。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910073122.6A CN109758630A (en) | 2019-01-28 | 2019-01-28 | A kind of absorption type haemodialyser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910073122.6A CN109758630A (en) | 2019-01-28 | 2019-01-28 | A kind of absorption type haemodialyser |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109758630A true CN109758630A (en) | 2019-05-17 |
Family
ID=66455288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910073122.6A Pending CN109758630A (en) | 2019-01-28 | 2019-01-28 | A kind of absorption type haemodialyser |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109758630A (en) |
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2019
- 2019-01-28 CN CN201910073122.6A patent/CN109758630A/en active Pending
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Legal Events
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| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190517 |