CN108295247A - A kind of spirulina capsule and preparation method thereof - Google Patents
A kind of spirulina capsule and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of spirulina capsules, are made of capsule shells and the content in capsule shells, wherein content includes spiral phycomycete, median chain triglyceride oil, beeswax, EGCG, spirulina kinases, sunflower oil, fatty acid glyceride.Capsule shells contain following component：Gelatin, glycerine and capsule shells beeswax.The invention also discloses the preparation methods of the spirulina capsule.The present invention dexterously combines above each ingredient of different role mechanism, makes composition from the formation of thrombus, the dissolving of increase thrombus is inhibited, accelerates the thrombus discharge of dissolving and the elasticity various aspects synergistic effect of enhancing blood vessel.
Description
Technical field
The invention belongs to medicines and health protection fields, and in particular to a kind of spirulina capsule and preparation method thereof.
Background technology
Due to the disorder etc. of variation and the living habit of accumulating many pressure, dietetic life, cause in our internal blood
Cholesterol and fat increase become muddy shape.Therefore it easy tos produce out thrombus, and blood component also disequilibrium, thus becomes
Even if thrombus occur also is difficult to the constitution dissolved.This thrombus is the cause of the major diseases such as myocardial infarction or brain gland.This
A little diseases no conscious sympton until falling ill mostly, it is most to be all suddenly seized with an illness, it even, can also there are sequelae.Therefore it is in
Among such social environment, mostly important is prevention work, not will produce thrombus and can be by shape to become
At the constitution fallen of thrombolysis, then must be by movement and diet come custom of making the life better.
Invention content
Single for spirulina food antithrombotic principle of the existing technology, poor storage stability and absorptivity be not high
Defect, provide a kind of spirulina capsule, while additionally providing the preparation method of the spirulina capsule.
The purpose of the present invention is what is be achieved through the following technical solutions：
A kind of spirulina capsule is made of capsule shells and the content that is located in the capsule shells, the content with
Parts by weight meter contains following component：3-8 parts of median chain triglyceride oil, 0.1-0.5 parts of EGCG, 1-4 parts of spiral phycomycete, spirulina
3-10 parts of 10-30 parts of kinases, 45-75 parts of sunflower oil, 3-10 parts of beeswax and fatty acid glyceride, the capsule shells are with parts by weight
Meter contains following component：10-30 parts of 40-70 parts of gelatin, 15-30 parts of glycerine and beeswax.
Preferably, wherein the content of the GECG is not less than 98%.
Preferably, wherein the activity of the spirulina kinases is not less than 1200FU.
Preferably, wherein the content contains following component in parts by weight：5 parts of median chain triglyceride oil, EGCG
8 parts of 0.3 part, 3 parts of spiral phycomycete, 20 parts of spirulina kinases, 60 parts of sunflower oil, 3.7 parts of beeswax and fatty acid glyceride, it is described
Capsule shells contain following component in parts by weight：25 parts of 45 parts of gelatin, 30 parts of glycerine and beeswax.
Preferably, wherein the content contains following component in parts by weight：6.28 parts of median chain triglyceride oil, EGCG
10 parts of 0.42 part, 4 parts of spiral phycomycete, 25 parts of spirulina kinases, 45 parts of sunflower oil, 9.3 parts of beeswax and fatty acid glyceride, institute
It states capsule shells and contains following component in parts by weight：10 parts of 70 parts of gelatin, 20 parts of glycerine and beeswax.
Preferably, wherein the content contains following component in parts by weight：5.8 parts of median chain triglyceride oil, EGCG
0.35 part, 3.2 parts of spiral phycomycete, 15 parts of spirulina kinases, 65 parts of sunflower oil, 6 parts of beeswax and fatty acid glyceride 4.65, institute
It states capsule shells and contains following component in parts by weight：30 parts of 40 parts of gelatin, 30 parts of glycerine and beeswax.
A kind of preparation method of spirulina capsule comprising following steps：
(1) it weighs：Weigh the median chain triglyceride oil of formula ratio, EGCG, spiral phycomycete, spirulina kinases, sunflower oil, interior
Tolerant beeswax, capsule shells beeswax, fatty acid glyceride, gelatin and glycerine, it is spare；
(2) dispensing：Spiral phycomycete, spirulina kinases, sunflower oil and fatty acid glyceride are uniformly mixed, mixed
Object；
Content beeswax and EGCG are added when median chain triglyceride oil is heated to 60-90 DEG C, stirring melting 0.5-1 is small
When, oleosol is obtained, is then cooled to 15-30 DEG C of heat preservation, for use；
Above-mentioned mixture is added in oleosol, it is stirring while adding, colloid mill 2-3 times is crossed after mixing, takes off gas
Bubble, it is for use to obtain content；
(3) change glue：First it will be heated to 50-70 DEG C in capsule shells beeswax, glycerine being put into glue tank, is 15-45rpm in rotating speed
Stirring under gelatin is slowly added to, and continue to be heated to 80-100 DEG C, stirring tanning 0.5-1 hour must after de-bubbled
To glue, and 80-120 mesh filters, and is placed 4-6 hours at 40-60 DEG C, spare；
(4) pressure watt：Soft capsule press is started, compacting capsule and pill is carried out, controls the temperature and relative humidity of production environment, is pressed
The capsule and pill made is transported in rotating cage with conveyer belt and is shaped 3-5 hours；
(5) ball, drying are washed：The edible alcohol for being 15-95% with volumetric concentration carries out cleaning capsule and pill, until capsule and pill surface light
Clean, bright, then capsule and pill is gone to hothouse drying by no grease, control dry 24-30 DEG C of room temperature, relative humidity 20-
30%, it is 24-48 hours dry, soft capsule is obtained, soft capsule is fitted into bottle.
Preferably, in the step (4), the production environment temperature is 18-22 DEG C, relative humidity 40-60%, content
The loading amount of object is 0.3g/.
Compared with prior art, the present invention has at least the following advantages：
(1) spirulina capsule provided by the present invention, wherein spirulina kinases be proved to can effectively thrombus,
Cholesterol, acidification type lipid in decomposer are mainly decomposed, there is inhibition thrombosis and thrombus, the work for reducing cholesterol
With；EGCG has effects that inhibit low-density albumen (insoluble fibrin) content in blood, and it is with stronger antioxygen
The property changed, not only improves the toughness of vascular wall, also extends the stability of the composition system；Not only contain in propolis abundant
Flavones but also there are many ingredient, makes it have softening blood vessel, reduces fragility of blood vessels, effectively reduce thrombosis, treatment of vascular
Hardening, improves the effect of microcirculation, that is, increases the toughness of blood vessel, also accelerate the discharge of thrombus；Spiral phycomycete, which has, to be changed
Human enteric bacteria is grown thickly state, and function normalization is helped digest, so that defecation is smooth, maintains the effect of body physiological environmental protection, rush
Into microcirculation；Absorption pattern of the median chain triglyceride oil for human body is different from other greases, and infiltration rate compares long-chain fat
Fast four times of acid, and it does not generate lipopexia, can dissolving cholesterol etc. well, reduce or avoid EGCG oxidations by air
Risk；Sunflower oil is most containing linoleic acid in vegetable oil, and linoleic acid has reduction blood fat, softening blood vessel, reduces blood pressure, promotees
Into the effect of microcirculation, the deposition for preventing human serum cholesterol in vascular wall can be played, enhance the toughness of blood vessel and is promoted micro-
Cycle；And the addition of fatty acid glyceride so that entire composition system is stablized, and each component in system is further enhanced
Effect.Above each ingredient of different role mechanism is dexterously combined, is made by spirulina capsule i.e. provided by the present invention
They accelerate the thrombus discharge of dissolving and the elasticity various aspects of enhancing blood vessel from the formation of thrombus, the dissolving of increase thrombus is inhibited
Synergistic effect, reaching, which makes human body become, not will produce thrombus, can fall the thrombolysis of formation and quickly dissolving
The constitution that thrombus excretes.
(2) spirulina capsule provided by the present invention swashs median chain triglyceride oil, EGCG, spiral phycomycete, spirulina
Enzyme, sunflower oil, fatty acid glyceride and beeswax scientific matching, all raw material is green material, safe and efficient, is adopted simultaneously
It uses capsule as carrier, carries and convenient, evaded the bad smell of the bitter taste and spirulina kinases of EGCG, for a long time
Take safe and nontoxic, side effect.
(3) EGCG is steadily scattered in median chain triglyceride oil in the present invention so that EGCG is by three acid of medium chain triglyceride
Ester wraps, the problem of not only ensure that the meltage of EGCG, also avoid EGCG oxidations by air so that the effect of EGCG can
Adequately to be used.
(4) spirulina capsule provided by the present invention can significantly improve spiral shell compared with the spiral algae product of the prior art
Revolve the absorbability and stability of phycocolloid capsule so that the resultant effect of each component is adequately embodied.
(5) spirulina capsule provided by the present invention, since saturation of the beeswax in content be not high, beeswax is distinguished
For in content component and capsule shells component, improving ratio of the beeswax in entire spirulina capsule, so that spiral
Phycocolloid capsule has better antithrombotic property.
Specific implementation mode
With reference to embodiment, the invention will be further described, and following embodiment is descriptive, is not limited
, protection scope of the present invention cannot be limited with this.
Unless otherwise defined, all technical and scientific terms used herein has and those skilled in the art of the invention
Normally understood identical meanings.If there are contradiction, it is subject to definition provided by the present application.
Heretofore described content beeswax is the beeswax for content in spirulina capsule, the capsule shells bee
Wax is the beeswax for capsule shells in spirulina capsule.
Unless otherwise stated, all percentage, parts by weight, ratio etc. herein are by weight.
Median chain triglyceride oil that the present invention uses, EGCG, spiral phycomycete, spirulina kinases, sunflower oil, glycerine fatty acid
Ester and beeswax are purchased in market.
Embodiment 1
(1) it weighs：Weigh 3 parts of median chain triglyceride oils, 0.1 part of EGCG, 1 part of spiral phycomycete, 25 parts of spirulina kinases, 60
Part sunflower oil, 5.9 parts of fatty acid glycerides, 5 parts of content beeswaxs, 30 parts of capsule shells beeswaxs, 50 parts of gelatin and 20 parts of glycerine, it is standby
With；
(2) dispensing：1 part of spiral phycomycete, 25 parts of spirulina kinases, 60 portions of sunflower oils and 5.9 parts of fatty acid glycerides are mixed
It closes uniformly, obtains mixture；
5 parts of content beeswaxs of addition and 0.1 part of EGCG, stirring melt when 3 parts of median chain triglyceride oils are heated to 60 DEG C
0.5 hour, oleosol is obtained, is then cooled to 25 DEG C of heat preservations, for use；
Mixture obtained by step (1) is sequentially added in factice liquid, it is stirring while adding, colloid mill 2- is crossed after mixing
3 times, bubble is taken off, obtains content, for use；
(3) change glue：First 50 DEG C will be heated in 30 parts of capsule shells beeswaxs, 20 parts of glycerine being put into glue tanks, be in rotating speed
By 50 parts of gelatin being slowly added to glue tanks under the stirring of 15rpm, and continue to be heated to 80 DEG C, stirring tanning 0.5 hour takes off
Glue is obtained after bubble, the filtering of 80 mesh is placed 4 hours at 40 DEG C, spare；
(4) pressure watt：Soft capsule press is started, carries out compacting capsule and pill, 18 DEG C of production environment temperature, relative humidity 40%,
Control content object 0.3g/, the capsule and pill suppressed are transported in rotating cage with conveyer belt and are shaped 3 hours；
(5) ball, drying are washed：The edible alcohol for being 20% with volumetric concentration carries out cleaning capsule and pill, until capsule and pill any surface finish,
Bright, then capsule and pill is gone to hothouse drying by no grease, control dry 24 DEG C of room temperature, relative humidity 20%, drying 24
Hour, soft capsule is fitted into bottle, 60/bottle.
Embodiment 2：
(1) it weighs：Weigh 5 parts of median chain triglyceride oils, 0.3 part of EGCG, 3 parts of spiral phycomycetes, 20 parts of spirulina kinases, 60
Part sunflower oil, 8 parts of fatty acid glycerides, 3.7 parts of content beeswaxs, 25 parts of capsule shells beeswaxs, 45 parts of gelatin and 30 parts of glycerine, it is standby
With；
(2) dispensing：3 parts of spiral phycomycetes, 20 parts of spirulina kinases, 60 portions of sunflower oils and 8 parts of fatty acid glycerides are mixed
Uniformly, mixture is obtained；
3.7 parts of content beeswaxs of addition and 0.3 part of EGCG, stirring are melted when 5 parts of median chain triglyceride oils are heated to 70 DEG C
Melt 0.8 hour, obtain oleosol, is then cooled to 20 DEG C of heat preservations, for use；
Mixture obtained by step (1) is sequentially added in factice liquid, it is stirring while adding, colloid mill 2- is crossed after mixing
3 times, bubble is taken off, it is for use to obtain content；
(3) change glue：First 60 DEG C will be heated in 25 parts of capsule shells beeswaxs, 30 parts of glycerine being put into glue tanks, be in rotating speed
By 45 parts of gelatin being slowly added to glue tanks under the stirring of 18rpm, and continue to be heated to 85 DEG C, stirring tanning 0.5 hour takes off
Glue is obtained after bubble, the filtering of 100 mesh is placed 4 hours at 50 DEG C, spare；
(4) pressure watt：Soft capsule press is started, carries out compacting capsule and pill, 20 DEG C of production environment temperature, relative humidity 45%,
Control content object 0.3g/, the capsule and pill suppressed are transported in rotating cage with conveyer belt and are shaped 3.5 hours；
(5) ball, drying are washed：The edible alcohol for being 25% with volumetric concentration carries out cleaning capsule and pill, until capsule and pill any surface finish,
Bright, then capsule and pill is gone to hothouse drying by no grease, control dry 27 DEG C of room temperature, relative humidity 25%, drying 30
Hour, soft capsule is fitted into bottle, 60/bottle.
Embodiment 3：
(1) it weighs：Weigh 4.74 parts of median chain triglyceride oils, 0.26 part of EGCG, 2.5 parts of spiral phycomycetes, 30 parts of spirulinas
Kinases, 55 portions of sunflower oils, 4 parts of fatty acid glycerides, 3.5 parts of content beeswaxs, 20 parts of capsule shells beeswaxs, 55 parts of gelatin and 25 parts
Glycerine, it is spare；
(2) dispensing：2.5 parts of spiral phycomycetes, 30 parts of spirulina kinases, 55 portions of sunflower oils and 4 parts of fatty acid glycerides are mixed
It closes uniformly, obtains mixture；
3.5 parts of content beeswaxs and 0.26 part of EGCG are added when 4.74 parts of median chain triglyceride oils are heated to 75 DEG C, is stirred
Melting 0.8 hour is mixed, oleosol is obtained, is then cooled to 20 DEG C of heat preservations, for use；
Mixture obtained by step (1) is sequentially added in factice liquid, it is stirring while adding, colloid mill 2- is crossed after mixing
3 times, bubble is taken off, it is for use to obtain content；
(3) change glue：First 58 DEG C will be heated in 20 parts of capsule shells beeswaxs, 25 parts of glycerine being put into glue tanks, be in rotating speed
By 55 parts of gelatin being slowly added to glue tanks under the stirring of 25rpm, and continue to be heated to 89 DEG C, stirring tanning 0.6 hour takes off
Glue is obtained after bubble, the filtering of 110 mesh is placed 6 hours at 50 DEG C, spare；
(4) pressure watt：Soft capsule press is started, carries out compacting capsule and pill, 20 DEG C of production environment temperature, relative humidity 52%,
Control content object 0.3g/, the capsule and pill suppressed are transported in rotating cage with conveyer belt and are shaped 4 hours；
(5) ball, drying are washed：The edible alcohol for being 30% with volumetric concentration carries out cleaning capsule and pill, until capsule and pill any surface finish,
Bright, then capsule and pill is gone to hothouse drying by no grease, control dry 27 DEG C of room temperature, relative humidity 23%, drying 32
Hour, soft capsule is fitted into bottle, 60/bottle.
Embodiment 4：
(1) it weighs：6.28 parts of median chain triglyceride oils, 0.42 part of EGCG, 4 parts of spiral phycomycetes, 25 parts of spirulinas are weighed to swash
Enzyme, 45 portions of sunflower oils, 10 parts of fatty acid glycerides, 9.3 parts of content beeswaxs, 10 parts of capsule shells beeswaxs, 70 parts of gelatin and 20 parts
Glycerine, it is spare；
(2) dispensing：4 parts of spiral phycomycetes, 25 parts of spirulina kinases, 45 portions of sunflower oils and 10 parts of fatty acid glycerides are mixed
Uniformly, mixture is obtained；
9.3 parts of content beeswaxs and 0.42 part of EGCG are added when 0.42 part of median chain triglyceride oil is heated to 75 DEG C, is stirred
Melting 1 hour is mixed, oleosol is obtained, is then cooled to 30 DEG C of heat preservations, for use；
Mixture obtained by step (1) is sequentially added in factice liquid, it is stirring while adding, colloid mill 2- is crossed after mixing
3 times, bubble is taken off, it is for use to obtain content；
(3) change glue：First 63 DEG C will be heated in 10 parts of capsule shells beeswaxs, 20 parts of glycerine being put into glue tanks, be in rotating speed
By 70 parts of gelatin being slowly added to glue tanks under the stirring of 30rpm, and continuing to be heated to 90 DEG C, stirring boils 0.65 hour,
Glue is obtained after de-bubbled, the filtering of 100 mesh is placed 6 hours at 50 DEG C, spare；
(4) pressure watt：Soft capsule press is started, carries out compacting capsule and pill, 22 DEG C of production environment temperature, relative humidity 60%,
Control content object 0.3g/, the capsule and pill suppressed are transported in rotating cage with conveyer belt and are shaped 4.5 hours；
(5) ball, drying are washed：The edible alcohol for being 42% with volumetric concentration carries out cleaning capsule and pill, until capsule and pill any surface finish,
Bright, then capsule and pill is gone to hothouse drying by no grease, control dry 30 DEG C of room temperature, relative humidity 30%, drying 42
Hour, soft capsule is fitted into bottle, 60/bottle.
Embodiment 5：
(1) it weighs：7.5 parts of median chain triglyceride oils, 0.5 part of EGCG, 3.5 parts of spiral phycomycetes, 10 parts of spirulinas are weighed to swash
Enzyme, 70 portions of sunflower oils, 3.5 parts of fatty acid glycerides, 5 parts of content beeswaxs, 15 parts of capsule shells beeswaxs, 60 parts of gelatin and 25 parts are sweet
Oil, it is spare；
(2) dispensing：By 3.5 parts of spiral phycomycetes, 10 parts of spirulina kinases, 70 portions of sunflower oils and 3.5 parts of fatty acid glycerides
It is uniformly mixed, obtains mixture；
5 parts of content beeswaxs of addition and 0.5 part of EGCG, stirring are melted when 7.5 parts of median chain triglyceride oils are heated to 90 DEG C
Melt 0.5 hour, obtain oleosol, is then cooled to 20 DEG C of heat preservations, for use；
Mixture obtained by step (1) is sequentially added in factice liquid, it is stirring while adding, colloid mill 2- is crossed after mixing
3 times, bubble is taken off, it is for use to obtain content；
(3) change glue：First 58 DEG C will be heated in 15 parts of capsule shells beeswaxs, 25 parts of glycerine being put into glue tanks, be in rotating speed
By 60 parts of gelatin being slowly added to glue tanks under the stirring of 35rpm, and continue to be heated to 87 DEG C, stirring tanning 0.7 hour takes off
Glue is obtained after bubble, the filtering of 120 mesh is placed 4 hours at 50 DEG C, spare；
(4) pressure watt：Soft capsule press is started, carries out compacting capsule and pill, 20 DEG C of production environment temperature, relative humidity 50%,
Control content object 0.3g/, the capsule and pill suppressed are transported in rotating cage with conveyer belt and are shaped 5 hours；
(5) ball, drying are washed：The edible alcohol for being 60% with volumetric concentration carries out cleaning capsule and pill, until capsule and pill any surface finish,
Bright, then capsule and pill is gone to hothouse drying by no grease, control dry 26 DEG C of room temperature, relative humidity 27%, drying 36
Hour, soft capsule is fitted into bottle, 60/bottle.
Embodiment 6：
(1) it weighs：5.8 parts of median chain triglyceride oils, 0.35 part of EGCG, 3.2 parts of spiral phycomycetes, 15 parts of spirulinas are weighed to swash
Enzyme, 65 portions of sunflower oils, 4.65 parts of fatty acid glycerides, 6 parts of content beeswaxs, 30 parts of capsule shells beeswaxs, 40 parts of gelatin and 30 parts
Glycerine, it is spare；
(2) dispensing：By 3.2 parts of spiral phycomycetes, 15 parts of spirulina kinases, 65 portions of sunflower oils and 4.65 parts of fatty acid glycerides
It is uniformly mixed, obtains mixture；
6 parts of content beeswaxs of addition and 0.35 part of EGCG, stirring are melted when 5.8 parts of median chain triglyceride oils are heated to 85 DEG C
Melt 0.8 hour, obtain oleosol, is then cooled to 25 DEG C of heat preservations, for use；
Mixture obtained by step (1) is sequentially added in factice liquid, it is stirring while adding, colloid mill 2- is crossed after mixing
3 times, bubble is taken off, it is for use to obtain content；
(3) change glue：First 70 DEG C will be heated in 30 parts of capsule shells beeswaxs, 30 parts of glycerine being put into glue tanks, be in rotating speed
By 40 parts of gelatin being slowly added to glue tanks under the stirring of 40rpm, and continue to be heated to 80 DEG C, stirring tanning 0.5 hour takes off
Glue is obtained after bubble, the filtering of 100 mesh is placed 6 hours at 50 DEG C, spare；
(4) pressure watt：Soft capsule press is started, compacting capsule and pill, 18-22 DEG C of production environment temperature, relative humidity 40- are carried out
60%, control content object 0.3g/, the capsule and pill suppressed is transported in rotating cage with conveyer belt and is shaped 5 hours；
(5) ball, drying are washed：The edible alcohol for being 83% with volumetric concentration carries out cleaning capsule and pill, until capsule and pill any surface finish,
Bright, then capsule and pill is gone to hothouse drying by no grease, control dry 30 DEG C of room temperature, relative humidity 28%, drying 45
Hour, soft capsule is fitted into bottle, 60/bottle.
Embodiment 7
In order to prove to be added merely EGCG in spiral algae product, and it is added after median chain triglyceride oil oil is molten
The effect of EGCG, wherein being mixed to get by spiral phycomycete, spirulina kinases, sunflower oil, content beeswax and fatty acid glyceride
Mixture, hereinafter referred to as spirulina essence, the spirulina essence in this test specimen is using the formula ratio in embodiment 5
It prepares, then by the preparation method of the spirulina capsule in any one of embodiment 1- embodiments 6, prepares capsule material；
30 wistar rats will be randomly divided into 5 groups, every group 6, each group is respectively：
1, blank group (Control) is gavaged and the same number of capsulae vacuus of administration group.
2, spirulina " Jinghuasu " essence capsule group (hereinafter referred to as sample 1), dosage 10kIUkg-1。
3, spirulina essence+EGCG Capsules groups (hereinafter referred to as sample 2), dosage 10kIUkg-1。
4, spirulina essence+EGCG+ median chain triglyceride oils Capsules group (hereinafter referred to as sample 3), dosage are
10kIU·kg-1。
Above-mentioned spirulina essence is prepared using the component and proportioning of embodiment 5, i.e., contains 3.5 parts in parts by weight
Spiral phycomycete, 10 parts of spirulina kinases, 70 portions of sunflower oils, 5 parts of content beeswaxs and 3.5 parts of fatty acid glycerides, and its capsule
Shell contains 15 parts of capsule shells beeswaxs, 60 parts of gelatin and 25 parts of glycerine, the EGCG content one in sample 1 and sample 2 in parts by weight
It causes, in parts by weight containing 1 part of EGCG.
It is administered daily 1 time, continuous 7 days.The 8th day after administration, rat is carried out with mass percent for 3.5% chloraldurate
Intraperitoneal anesthesia (1ml/100g), operation separation bilateral common carotid arteries.Respectively pad 1.2cm*3.0cm's under bilateral common carotid arteries
Plastic tab, with being impregnated with 50 μ l FeCl3Filter paper item (1.0cm*1.5cm) the covering Bilateral Cervical of solution (10%, w/w) always moves
Arteries and veins.Filter paper item is removed after 20min, cut color change interval and is cleaned with physiological saline, its length is measured after filter paper suck dry moisture, and
With analysis level precise weighing.
The weight of unit length thrombus is denoted as opposite bolt weight (mg/cm), and calculates anti-bolt rate (%) with following formula.
Anti- bolt rate %=(W controls-W administrations)/W controls × 100%
The average opposite bolt weight of W controls-control group；The average opposite bolt weight of W administrations-administration group.
Anti- bolt rate is calculated by above formula, and statistical analysis is carried out to result, the results are shown in Table 1.
The anti-bolt rate result of 1 different dosing group of table
| Group | Bolt weight (mgcm-1) | Anti- bolt rate (%) |
| Blank control group | 5.63±1.10 | / |
| Sample 1 | 2.33±0.76 | 58.61 |
| Sample 2 | 0.94±0.32 | 83.30 |
| Sample 3 | 3.62±1.01 | 35.70 |
The result shows that by being compared to blank control group and sample 3, it is significant anti-to illustrate that spirulina essence has
Bolt effect (P<0.05), the anti-bolt effect of sample 1 and sample 2 is significantly stronger than sample 3, illustrates that the addition of EGCG can enhance spiral shell
Revolve the anti-bolt effect of algae product；And the anti-bolt effect of sample 2 is significantly higher than sample 1 again, illustrates molten by median chain triglyceride oil
The EGCG that solution obtains is with than merely with EGCG with better anti-bolt effect.
It follows that the EGCG that the substance absorbed is dissolved in median chain triglyceride oil is improved, this is because EGCG is by middle chain
Triglyceride wraps, and the problem of not only ensure that the meltage of EGCG, also efficiently avoid EGCG oxidations by air, makes
Obtaining the effect of EGCG can adequately be used.
Embodiment 8 --- EGCG improves the stability of composition system
According to the preparation method of embodiment 7, sample 1, sample 2 and sample 3 are prepared, then sample 1, sample 2 and sample 3
It is respectively placed in 37 DEG C of environment, after 30 days, the enzymatic activity of each sample is measured with fibrin plate method, calculates remnant enzyme activity
Power.
The residual enzyme activity situation of 2 sample 1 of table, sample 2 and sample 3
| Group | Residual enzyme activity |
| Sample 1 | 53.6% |
| Sample 2 | 82% |
| Sample 3 | 28.9% |
As a result：After the composition powder of sample 1, sample 2 and sample 3 is placed 30 days under 37 DEG C of environment, residual enzyme activity
Respectively 53.6%, 82% and 28.9% illustrate that spirulina capsule improves the temperature stability of NK.
More than, it is merely preferred embodiments of the present invention, but the protection domain invented is not limited thereto, it is any ripe
Know those skilled in the art in the technical scope disclosed by the present invention, the change or replacement that can be readily occurred in should all be contained
Lid is within protection scope of the present invention.Therefore, the scope of protection of the invention shall be subject to the scope of protection specified in the patent claim.
Claims (5)
1. a kind of spirulina capsule is made of capsule shells and the content being located in the capsule shells, it is characterised in that：It is described
Content contains following component in parts by weight：3-8 parts of median chain triglyceride oil, EGCG0.1-0.5 parts, 1-4 parts of spiral phycomycete,
3-10 parts of 10-30 parts of spirulina kinases, 45-75 parts of sunflower oil, 3-10 parts of content beeswax and fatty acid glyceride, the glue
Softgel shell contains following component in parts by weight：10-30 parts of 40-70 parts of gelatin, 15-30 parts of glycerine and capsule shells beeswax, it is described
The content of EGCG is not less than 98%, and the activity of the spirulina kinases is not less than 1200FU.
2. according to the spirulina capsule described in claim 1, which is characterized in that the content contains as follows in parts by weight
Component：5 parts of median chain triglyceride oil, 0.3 part of EGCG, 3 parts of spiral phycomycete, 20 parts of spirulina kinases, 60 parts of sunflower oil, content
8 parts of 3.7 parts of object beeswax and fatty acid glyceride, the capsule shells contain following component in parts by weight：45 parts of gelatin, glycerine
30 parts and 25 parts of capsule shells beeswax.
3. according to the spirulina capsule described in any one of claim 1 and 2, which is characterized in that the content is with parts by weight
Meter contains following component：6.28 parts of median chain triglyceride oil, 0.42 part of EGCG, 4 parts of spiral phycomycete, 25 parts of spirulina kinases, certain herbaceous plants with big flowers
10 parts of 45 parts of caul-fat, 9.3 parts of content beeswax and fatty acid glyceride, the capsule shells contain such as the following group in parts by weight
Point：10 parts of 70 parts of gelatin, 20 parts of glycerine and capsule shells beeswax.
4. spirulina capsule according to any one of claim 1-3, which is characterized in that the content is in parts by weight
Contain following component：5.8 parts of median chain triglyceride oil, 0.35 part of EGCG, 3.2 parts of spiral phycomycete, 15 parts of spirulina kinases, certain herbaceous plants with big flowers
Caul-fat 65,6 parts of content beeswax and fatty acid glyceride 4.65, the capsule shells contain following component in parts by weight：It is bright
30 parts of 40 parts of glue, 30 parts of glycerine and capsule shells beeswax.
5. a kind of preparation method of spirulina capsule according to any one of claim 1-4, it is characterised in that：This method
Include the following steps：
(1) it weighs：Weigh median chain triglyceride oil, EGCG, spiral phycomycete, spirulina kinases, sunflower oil, the content of formula ratio
Beeswax, capsule shells beeswax, fatty acid glyceride, gelatin and glycerine, it is spare；
(2) dispensing：Spiral phycomycete, spirulina kinases, sunflower oil and fatty acid glyceride are uniformly mixed, mixture is obtained；
Addition content beeswax and EGCG, stirring melting 0.5-1 hours obtain when median chain triglyceride oil is heated to 60-90 DEG C
To oleosol, it is then cooled to 15-30 DEG C of heat preservation, for use；
Above-mentioned mixture is added in oleosol, it is stirring while adding, colloid mill 2-3 times is crossed after mixing, is taken off bubble, is obtained
Content is for use；
(3) change glue：First it will be heated to 50-70 DEG C in capsule shells beeswax, glycerine being put into glue tank, is stirring for 15-45rpm in rotating speed
It mixes and is slowly added to gelatin under state, and continue to be heated to 80-100 DEG C, stirring tanning 0.5-1 hours obtains glue after de-bubbled
Liquid, and 80-120 mesh filters, and is placed 4-6 hours at 40-60 DEG C, it is spare；
(4) pressure watt：Soft capsule press is started, compacting capsule and pill is carried out, the temperature and relative humidity of production environment is controlled, suppresses
Capsule and pill be transported in rotating cage and shape 3-5 hours with conveyer belt；
(5) ball, drying are washed：The edible alcohol for being 15-95% with volumetric concentration carries out cleaning capsule and pill, until capsule and pill any surface finish,
Bright, then capsule and pill is gone to hothouse drying by no grease, it is 24-30 DEG C to control dry room temperature, relative humidity 20-
30%, it is 24-48 hours dry, soft capsule is obtained, soft capsule is fitted into bottle.
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| CN201810299521.XA CN108295247A (en) | 2018-04-04 | 2018-04-04 | A kind of spirulina capsule and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110522037A (en) * | 2019-08-29 | 2019-12-03 | 南京大学昆山创新研究院 | A kind of chlorella pyrenoidosa capsule with health care function and preparation method thereof |
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2018
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110522037A (en) * | 2019-08-29 | 2019-12-03 | 南京大学昆山创新研究院 | A kind of chlorella pyrenoidosa capsule with health care function and preparation method thereof |
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Application publication date: 20180720 |