CN108295032A - The method that Chinese medicinal granule is prepared using resistant dextrin - Google Patents
The method that Chinese medicinal granule is prepared using resistant dextrin Download PDFInfo
- Publication number
- CN108295032A CN108295032A CN201810275792.1A CN201810275792A CN108295032A CN 108295032 A CN108295032 A CN 108295032A CN 201810275792 A CN201810275792 A CN 201810275792A CN 108295032 A CN108295032 A CN 108295032A
- Authority
- CN
- China
- Prior art keywords
- extraction
- resistant dextrin
- chinese medicinal
- spray
- medicinal granule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
It is that selection medicinal material best in quality is smashed or shredded the invention discloses the method for preparing Chinese medicinal granule using resistant dextrin；Decoction extraction is carried out after immersion；Low temperature concentration obtains extraction concentrate；Resistant dextrin is added into extraction concentrate, using spray drying, resistant dextrin is added and is uniformly mixed, pelletize, whole grain is at Chinese medicinal granule.Replace maltodextrin as basic raw material using resistant dextrin, the function of intestinal canal for enhancing user, improves the absorption of Chinese medicinal granule, and application range and target user are more extensive, make hyperglycemia population and diabetic that can take, is conducive to the popularization and application of Chinese medicinal granule.The technology of preparing of the present invention is safe and effective, and operating process is simple, can effectively solve the problem that the prior art due to blood glucose rise problem caused by basic material, contributes to the application and popularization of Chinese medicinal granular formulation, has a vast market foreground.
Description
Technical field
The present invention relates to a kind of preparation methods of Chinese medicinal granule, specifically prepare Chinese medicine preparation using resistant dextrin
The method of grain, belongs to Chinese medicine preparation field.
Background technology
Chinese medicine is the main means of Chinese traditional treatment disease for thousands of years, and wherein decoction is that tcm clinical practice application is earliest, most wide
A kind of general dosage form, has the characteristics that absorb that fast, to play drug effect rapid, but traditional Chinese medicine decoction to drug-decocting appliance, with water, fire
Time, time, special decocting method etc. have strict requirements, and assurance is improper will to influence drug effect.And it is saved as people live
The quickening played, traditional Chinese medicine decoction have been unable to meet the allegro life style of modern, at this time Chinese medicinal granule meet the tendency of and
It is raw.
Chinese medicinal granule also known as exempts to decoct Chinese medicine, refers under guidance of traditional Chinese medicine theory, to meet concocted specification, quality
The excellent prepared slices of Chinese crude drugs are raw material, are process using modern high novel technique, nature and flavor, effect and the former prepared slices of Chinese crude drugs one
It causes, the granule used for tcm clinical practice formula.Compared with the former prepared slices of Chinese crude drugs, has and be not required to decoct, directly take after mixing it with water, dose
The advantages such as less, curative for effect, convenient and efficient.
Include spray drying process in the production technology of Chinese medicinal granule, this process usually requires addition maltodextrin and makees
For basic raw material, and maltodextrin is starch generates after hydrolysis in vitro, can without ptyalin hydrolysis directly into
Enter into human stomach, and glucose is further digested to by small intestinal mucosa enzyme, it is easy to it is digested and assimilated completely for human body, and wheat
The intake of bud saccharin can cause human glucose to absorb rapidly, and blood glucose is made to increase, crisis health.So edible contain malt
The Chinese medicinal granule of dextrin is also likely to blood sugar for human body can be caused to increase, can particularly with hyperglycemia population or diabetic
There can be the influence of bigger.So hyperglycemia or diabetic should just avoid intake malt saccharin and containing maltodextrins
Chinese medicinal granule.Nevertheless, medium-height grass granule still mainly uses maltodextrin to be produced as basic raw material at present
It prepares.
Different from maltodextrin, resistant dextrin is the indigestibility ingredient industrial technology extraction process and essence that will bake dextrin
A kind of Low Caloric Polydextrose made of refining, belongs to low molecule water-soluble dietary fiber.Resistant dextrin has anti-digestion enzyme effect
Characteristic is a kind of food material with lower caloric, and absorption will not be digested in alimentary canal, can be directly entered large intestine, has high digestion
Tolerance, low-glycemic, low insulin index can solve the problems, such as that maltodextrin leads to blood glucose rise.In addition, anti-
Property dextrin can be utilized by the beneficial microbe in human body alimentary canal, stimulation growth of probiotics breed, certain tune is provided for human body
Substance is saved, human body intestinal canal function is improved, promotes Chinese medicinal granule and absorbs.And there is presently no find to use resistant dextrin conduct
The report that basic material is prepared for Chinese medicinal granule production.
Invention content
It is an object of the invention to overcome to prepare Chinese medicinal granule as basic raw material using maltodextrin at present and draw
The raised defect of blood sugar for human body is played, and discloses a kind of method that Chinese medicinal granule is prepared using resistant dextrin.
To achieve the goals above, the present invention adopts the following technical scheme that：
A. raw material is screened：Medicinal material best in quality is selected, impurity is removed, cleans up, smash or shred；
B. extraction is decocted：Decoction extraction, the wherein mixing ratio of spice and water are carried out after the spice of screening is impregnated 5 ~ 120 min
It is 1：20~1：80, Extracting temperature is 60 DEG C ~ 100 DEG C, and extraction time is 0.5 ~ 3.5h, and extraction time is 1 ~ 3 time, merges and decocts
Liquid, filtering；
C. low temperature concentrates：Thickening temperature is 40 ~ 60 DEG C, and it is 5% ~ 25% to be concentrated into solid content, obtains extraction concentrate；
D. it is spray-dried：Resistant dextrin is added into extraction concentrate, is uniformly mixed, makes the solid content of mixed solution be
10% ~ 25%, to above-mentioned mixed solution using being spray-dried, spray drying EAT is 70 DEG C ~ 140 DEG C, charging rate 1.0
~ 3.5mL/min, temperature of charge are 40 DEG C ~ 70 DEG C；
E. dry granulation：The resistant dextrin of spray-dried powders addition 0.1 ~ 25% is uniformly mixed, mixed-powder is obtained, will mix
Powder granulation is closed, the Chinese medicinal granule of 20 ~ 60 mesh is made in whole grain.
The present invention having the beneficial effect that compared with the existing technology：Resistant dextrin is used instead of former based on maltodextrin
The problem of material, effective solution user's blood glucose rise, while can also enhance the function of intestinal canal of user, improve Chinese medicine and matches
The absorption of square particle, application range and target user are more extensive, make hyperglycemia population and diabetic that can take, have
Conducive to the popularization and application of Chinese medicinal granule.The technology of preparing of the present invention is safe and effective, and operating process is simple, can effectively solve the problem that
The prior art contributes to the application and popularization of Chinese medicinal granular formulation, has due to blood glucose rise problem caused by basic material
Vast market prospect.
Specific implementation mode
The present invention is described in further details below by example, these examples are only used for illustrating the present invention, and unlimited
Protection scope of the present invention processed.
Embodiment one：
A. raw material is screened：Medicinal material best in quality is selected, impurity is removed, cleans up, smash or shred；
B. extraction is decocted：Decoction extraction will be carried out after 60 min of raw material soaking of screening, the mixing ratio of wherein spice and water is
1：30, Extracting temperature is 65 DEG C, extraction time 1h, and extraction time is 2 times, merges and decocts liquid, filtering；
C. low temperature concentrates：Thickening temperature is 50 DEG C, and it is 10% to be concentrated into solid content, obtains extraction concentrate；
D. it is spray-dried：Resistant dextrin is added into extraction concentrate, is uniformly mixed, makes the solid content of mixed solution be
20%, to above-mentioned mixed solution using being spray-dried, spray drying EAT is 80 DEG C, charging rate 2.0mL/min, object
Material temperature degree is 50 DEG C；
E. dry granulation：The resistant dextrin of spray-dried powders addition 2% is uniformly mixed, mixed-powder is obtained, by mixed-powder
The Chinese medicinal granule of 30 mesh is made in granulation, whole grain.
Embodiment two：
A. raw material is screened：Medicinal material best in quality is selected, impurity is removed, cleans up, smash or shred；
B. extraction is decocted：Decoction extraction will be carried out after 30 min of raw material soaking of screening, the mixing ratio of wherein spice and water is
1：20, Extracting temperature is 65 DEG C, extraction time 2h, and extraction time is 3 times, merges and decocts liquid, filtering；
C. low temperature concentrates：Thickening temperature is 50 DEG C, and it is 8% to be concentrated into solid content, obtains extraction concentrate；
D. it is spray-dried：Resistant dextrin is added into extraction concentrate, is uniformly mixed, makes the solid content of mixing solution
It is 15%, to above-mentioned mixed solution using being spray-dried, spray drying EAT is 80 DEG C, charging rate 1.5mL/min,
Temperature of charge is 50 DEG C；
E. dry granulation：The resistant dextrin of spray-dried powders addition 1% is uniformly mixed, mixed-powder is obtained, by mixed-powder
The Chinese medicinal granule of 20 mesh is made in granulation, whole grain.
Claims (3)
1. the method for preparing Chinese medicinal granule using resistant dextrin, it is characterised in that be to adopt the following technical scheme that：
A. raw material is screened：Medicinal material best in quality is selected, impurity is removed, cleans up, smash or shred；
B. extraction is decocted：Decoction extraction, the wherein mixing ratio of spice and water are carried out after the spice of screening is impregnated 5 ~ 120 min
It is 1：20~1：80, Extracting temperature is 60 DEG C ~ 100 DEG C, and extraction time is 0.5 ~ 3.5h, and extraction time is 1 ~ 3 time, merges and decocts
Liquid, filtering；
C. low temperature concentrates：Thickening temperature is 40 ~ 60 DEG C, and it is 5% ~ 25% to be concentrated into solid content, obtains extraction concentrate；
D. it is spray-dried：Resistant dextrin is added into extraction concentrate, is uniformly mixed, makes the solid content of mixed solution be
10% ~ 25%, to above-mentioned mixed solution using being spray-dried, spray drying EAT is 70 DEG C ~ 140 DEG C, charging rate 1.0
~ 3.5mL/min, temperature of charge are 40 DEG C ~ 70 DEG C；
E. dry granulation：The resistant dextrin of spray-dried powders addition 0.1 ~ 25% is uniformly mixed, mixed-powder is obtained, will mix
Powder granulation is closed, the Chinese medicinal granule of 20 ~ 60 mesh is made in whole grain.
2. the method according to claim 1 for preparing Chinese medicinal granule using resistant dextrin, it is characterised in that：
A. extraction is decocted：Decoction extraction will be carried out after 60 min of raw material soaking of screening, the mixing ratio of wherein spice and water is
1：30, Extracting temperature is 65 DEG C, extraction time 1h, and extraction time is 2 times, merges and decocts liquid, filtering；
B. low temperature concentrates：Thickening temperature is 50 DEG C, and it is 10% to be concentrated into solid content, obtains extraction concentrate；
C. it is spray-dried：Resistant dextrin is added into extraction concentrate, is uniformly mixed, makes the solid content of mixed solution be
20%, to above-mentioned mixed solution using being spray-dried, spray drying EAT is 80 DEG C, charging rate 2.0mL/min, object
Material temperature degree is 50 DEG C；
D. dry granulation：The resistant dextrin of spray-dried powders addition 2% is uniformly mixed, mixed-powder is obtained, by mixed-powder
The Chinese medicinal granule of 30 mesh is made in granulation, whole grain.
3. the method according to claim 1 for preparing Chinese medicinal granule using resistant dextrin, it is characterised in that：
A. extraction is decocted：Decoction extraction will be carried out after 30 min of raw material soaking of screening, the mixing ratio of wherein spice and water is
1：20, Extracting temperature is 65 DEG C, extraction time 2h, and extraction time is 3 times, merges and decocts liquid, filtering；
B. low temperature concentrates：Thickening temperature is 50 DEG C, and it is 8% to be concentrated into solid content, obtains extraction concentrate；
C. it is spray-dried：Resistant dextrin is added into extraction concentrate, is uniformly mixed, makes the solid content of mixing solution
It is 15%, to above-mentioned mixed solution using being spray-dried, spray drying EAT is 80 DEG C, charging rate 1.5mL/min,
Temperature of charge is 50 DEG C；
D. dry granulation：The resistant dextrin of spray-dried powders addition 1% is uniformly mixed, mixed-powder is obtained, by mixed-powder
The Chinese medicinal granule of 20 mesh is made in granulation, whole grain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810275792.1A CN108295032A (en) | 2018-03-30 | 2018-03-30 | The method that Chinese medicinal granule is prepared using resistant dextrin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810275792.1A CN108295032A (en) | 2018-03-30 | 2018-03-30 | The method that Chinese medicinal granule is prepared using resistant dextrin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108295032A true CN108295032A (en) | 2018-07-20 |
Family
ID=62847971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810275792.1A Pending CN108295032A (en) | 2018-03-30 | 2018-03-30 | The method that Chinese medicinal granule is prepared using resistant dextrin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108295032A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110742226A (en) * | 2019-10-18 | 2020-02-04 | 上海鹊喜生物科技有限公司 | Anti-depression solid beverage and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167801A (en) * | 2007-10-10 | 2008-04-30 | 江阴天江药业有限公司 | Method for preparing scutellaria dispensing granule |
-
2018
- 2018-03-30 CN CN201810275792.1A patent/CN108295032A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167801A (en) * | 2007-10-10 | 2008-04-30 | 江阴天江药业有限公司 | Method for preparing scutellaria dispensing granule |
Non-Patent Citations (3)
| Title |
|---|
| 刘丽芳: "《中药分析学》", 31 August 2015, 中国医药科技出版社 * |
| 吴宇澄: "《临床内分泌与代谢疾病》", 30 September 2017, 吉林科学技术出版社 * |
| 黄继红: "《抗性淀粉生产技术及其应用》", 31 January 2017, 河南科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110742226A (en) * | 2019-10-18 | 2020-02-04 | 上海鹊喜生物科技有限公司 | Anti-depression solid beverage and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107441349A (en) | It is a kind of that there is hypoglycemic, hypolipemic function pulvis and preparation method thereof | |
| CN108392519A (en) | A kind of hypoglycemic composition and its preparation and application | |
| CN102727569A (en) | Preparation method of licorice particles for livestock and poultry | |
| CN104522384A (en) | Petiolus trachycarpi husk-containing growth-promoting crucian feed and preparation method thereof | |
| CN104857088A (en) | Preparation method of mulberry leaf compound capsule for lowering blood glucose in assistant manner | |
| CN103689249A (en) | Broiler feed containing jujube bark | |
| CN106387051B (en) | Phyllostachys pracecox shoot dietary fiber yoghourt and preparation method thereof | |
| CN104026399A (en) | Growth-promoting mandarin fish feed and preparation method thereof | |
| CN103859399B (en) | A kind of corn stigma nutritional health food and preparation method thereof | |
| CN106261450A (en) | A kind of Haematococcus Pluvialis effervescent tablet of heat clearing away and internal heat reducing and preparation method thereof | |
| CN102670660B (en) | Processing method and application of aspongopus | |
| CN108295032A (en) | The method that Chinese medicinal granule is prepared using resistant dextrin | |
| CN101642207A (en) | Nutritive rice capable of decreasing blood lipid and production technology thereof | |
| CN104069370A (en) | Healthcare effervescent tablet for adjuvant treatment on diabetes and preparation method of healthcare effervescent tablet | |
| CN104666842B (en) | One seed ginseng stilbene monkey mushroom health products and preparation method thereof | |
| CN102813850A (en) | Traditional Chinese medicine composition for preventing and treating poultry coccidiosis and preparation method of traditional Chinese medicine composition | |
| CN105901246A (en) | Paste herbal tea for reducing blood sugar and preparing method thereof | |
| CN104336394A (en) | Special health feed for pig and preparation method of special health feed for pig | |
| CN104026398A (en) | Mandarin fish feed with pine needle meal and preparation method thereof | |
| CN108208646A (en) | A kind of preparation method of hypoglycemic nutrient powder | |
| CN107927366A (en) | New disease-resistant lamb supplement material of height and preparation method thereof | |
| CN103704496A (en) | Formula forage for controlling respiratory broiler chicken respiratory diseases | |
| CN105543060A (en) | Vinegar beverage capable of treating calculus and preparation method of vinegar beverage | |
| CN105325885A (en) | Crisp kelp and fishbone chips capable of increasing bone mineral density | |
| CN111150811A (en) | Formula of blood sugar reducing powder |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180720 |