CN108290919B - 具有上皮屏障增强特性的阿奇霉素衍生物 - Google Patents

具有上皮屏障增强特性的阿奇霉素衍生物 Download PDF

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Publication number
CN108290919B
CN108290919B CN201680067151.6A CN201680067151A CN108290919B CN 108290919 B CN108290919 B CN 108290919B CN 201680067151 A CN201680067151 A CN 201680067151A CN 108290919 B CN108290919 B CN 108290919B
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oxy
heptamethyl
ethyl
oxa
tetrahydroxy
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CN201680067151.6A
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Chinese (zh)
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CN108290919A (zh
Inventor
F·R·加达松
F·莱曼
P·特奥多罗维奇
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Epiendo Pharmaceuticals ehf
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Epiendo Pharmaceuticals ehf
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Priority to CN202210535850.6A priority Critical patent/CN114933620B/zh
Publication of CN108290919A publication Critical patent/CN108290919A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Materials For Medical Uses (AREA)
CN201680067151.6A 2015-11-19 2016-11-21 具有上皮屏障增强特性的阿奇霉素衍生物 Active CN108290919B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210535850.6A CN114933620B (zh) 2015-11-19 2016-11-21 具有上皮屏障增强特性的阿奇霉素衍生物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1520419.1 2015-11-19
GBGB1520419.1A GB201520419D0 (en) 2015-11-19 2015-11-19 Compounds
PCT/EP2016/078360 WO2017085329A1 (en) 2015-11-19 2016-11-21 Azithromycin derivatives with epithelial barrier enhancement properties

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202210535850.6A Division CN114933620B (zh) 2015-11-19 2016-11-21 具有上皮屏障增强特性的阿奇霉素衍生物

Publications (2)

Publication Number Publication Date
CN108290919A CN108290919A (zh) 2018-07-17
CN108290919B true CN108290919B (zh) 2022-06-17

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ID=55133040

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Application Number Title Priority Date Filing Date
CN201680067151.6A Active CN108290919B (zh) 2015-11-19 2016-11-21 具有上皮屏障增强特性的阿奇霉素衍生物
CN202210535850.6A Active CN114933620B (zh) 2015-11-19 2016-11-21 具有上皮屏障增强特性的阿奇霉素衍生物

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Country Status (19)

Country Link
US (3) US10723752B2 (https=)
EP (2) EP3377511B1 (https=)
JP (2) JP6849896B2 (https=)
KR (2) KR20240157138A (https=)
CN (2) CN108290919B (https=)
CA (1) CA3005088A1 (https=)
CY (1) CY1123418T1 (https=)
DK (1) DK3377511T3 (https=)
ES (1) ES2810703T3 (https=)
GB (1) GB201520419D0 (https=)
HR (1) HRP20201246T1 (https=)
HU (1) HUE050307T2 (https=)
LT (1) LT3377511T (https=)
PL (1) PL3377511T3 (https=)
PT (1) PT3377511T (https=)
RS (1) RS60698B1 (https=)
SI (1) SI3377511T1 (https=)
SM (1) SMT202000426T1 (https=)
WO (1) WO2017085329A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201520419D0 (en) 2015-11-19 2016-01-06 Epi Endo Pharmaceuticals Ehf Compounds
KR20220156570A (ko) 2020-03-12 2022-11-25 조에티스 서비시즈 엘엘씨 면역조절성 유레아 아잘라이드
AU2022343476B2 (en) * 2021-09-07 2025-02-20 Zoetis Services Llc Immunomodulating azalides
CN121038797A (zh) 2023-03-22 2025-11-28 艾比恩多制药有限责任公司 用于治疗嗜酸性粒细胞相关疾病的阿奇霉素衍生物
GB202404587D0 (en) 2024-03-28 2024-05-15 Epiendo Pharmaceuticals Ehf Chemical forms
GB202412461D0 (en) 2024-08-23 2024-10-09 Epiendo Pharmaceuticals Ehf Medial use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002055531A1 (en) * 2001-01-09 2002-07-18 Pliva D.D. Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy
CN1820017A (zh) * 2003-05-13 2006-08-16 葛兰素集团有限公司 4＂位取代的大环内酯类
WO2012131396A1 (en) * 2011-04-01 2012-10-04 Norbrook Laboratories Limited 3 -descladinosyl-o- carbamoyl functionalized derivatives of azithromycin

Family Cites Families (16)

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US3725385A (en) 1970-11-02 1973-04-03 Abbott Lab Process for the demethylation of 3-amino macrolides
AU2003219770B2 (en) * 2002-02-15 2008-10-09 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
RU2330858C2 (ru) 2002-07-08 2008-08-10 Глаксомитклайн Истраживацки Центар Загреб Д.О.О. Новые соединения, составы и способы лечения воспалительных заболеваний и состояний
ITMI20022292A1 (it) 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
PT1851236E (pt) 2005-01-13 2010-10-25 Glaxosmithkline Zagreb Macrólidos com actividade anti-inflamatória
EP1841776B1 (en) * 2005-01-13 2008-12-31 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Decladinosyl-macrolides with anti-inflammatory activity
CN1837225A (zh) 2005-08-23 2006-09-27 济南思创生物技术有限公司 阿奇霉素衍生物及其制法和药物应用
RU2455308C2 (ru) 2006-05-01 2012-07-10 Тайсо Фармасьютикал Ко., Лтд. Макролидные производные
CN101074251B (zh) * 2007-06-22 2011-06-15 山东大学 阿奇霉素4＂-氨甲酸酯衍生物、制备方法及其药物组合物
WO2009006403A2 (en) * 2007-06-29 2009-01-08 Georgia Tech Research Corporation Non-peptide macrocyclic histone deacetylase (hdac) inhibitors and methods of making and using thereof
WO2010086351A1 (en) * 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 3'-n-substituted 9-deoxo-9a-methyl-9a-aza-homoerythromycin having antimalarial activity
CA2814333A1 (en) * 2010-10-10 2012-04-19 Synovo Gmbh Anti-inflammatory macrolides
EP2831083A4 (en) * 2012-03-27 2016-03-09 Michael W Burnet INFLAMMATORY MAKROLIDE
AU2014252462A1 (en) 2013-04-10 2015-10-01 Probiotic Pharmaceuticals Aps Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect
GB201520419D0 (en) 2015-11-19 2016-01-06 Epi Endo Pharmaceuticals Ehf Compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002055531A1 (en) * 2001-01-09 2002-07-18 Pliva D.D. Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy
CN1820017A (zh) * 2003-05-13 2006-08-16 葛兰素集团有限公司 4＂位取代的大环内酯类
WO2012131396A1 (en) * 2011-04-01 2012-10-04 Norbrook Laboratories Limited 3 -descladinosyl-o- carbamoyl functionalized derivatives of azithromycin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
阿奇霉素新衍生物的设计、合成及抗病毒活性;谢麟等;《药学学报》;20021231;第37卷(第12期);第942-945页 *

Also Published As

Publication number Publication date
HRP20201246T1 (hr) 2020-11-13
US20220106349A1 (en) 2022-04-07
WO2017085329A1 (en) 2017-05-26
HUE050307T2 (hu) 2020-11-30
SI3377511T1 (sl) 2020-10-30
US20200317710A1 (en) 2020-10-08
CN108290919A (zh) 2018-07-17
KR20240157138A (ko) 2024-10-31
PL3377511T3 (pl) 2020-11-16
US12049477B2 (en) 2024-07-30
CY1123418T1 (el) 2021-12-31
CN114933620B (zh) 2026-03-31
EP3708573A1 (en) 2020-09-16
JP2018534324A (ja) 2018-11-22
US20180354981A1 (en) 2018-12-13
LT3377511T (lt) 2020-09-25
US10723752B2 (en) 2020-07-28
JP6849896B2 (ja) 2021-03-31
EP3377511A1 (en) 2018-09-26
RS60698B1 (sr) 2020-09-30
JP2021073303A (ja) 2021-05-13
KR102724114B1 (ko) 2024-10-29
HK1255270A1 (en) 2019-08-09
JP7256558B2 (ja) 2023-04-12
US11236120B2 (en) 2022-02-01
DK3377511T3 (da) 2020-08-17
ES2810703T3 (es) 2021-03-09
CA3005088A1 (en) 2017-05-26
PT3377511T (pt) 2020-08-21
EP3377511B1 (en) 2020-05-13
GB201520419D0 (en) 2016-01-06
CN114933620A (zh) 2022-08-23
KR20180077282A (ko) 2018-07-06
SMT202000426T1 (it) 2020-09-10

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