CN108289800B - Liquid oral composition - Google Patents
Liquid oral composition Download PDFInfo
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- CN108289800B CN108289800B CN201680069781.7A CN201680069781A CN108289800B CN 108289800 B CN108289800 B CN 108289800B CN 201680069781 A CN201680069781 A CN 201680069781A CN 108289800 B CN108289800 B CN 108289800B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The present invention relates to a liquid oral composition which maintains a good feeling in use and has an excellent effect of removing colored stains. The liquid oral composition of the present invention contains the following components (a), (B) and (C): (A) 1 or 2 or more carbonate salts selected from sodium bicarbonate, sodium carbonate, and sodium sesquicarbonate, in an amount of 0.1 to 2 mass% in terms of carbonic acid; (B) 0.2 to 1.7% by mass of an anionic surfactant; and (C) water, wherein the content of the polyvalent metal cation (D) is less than 0.1 times mole relative to the component (A), the value ((A) × (B)) which is the product of the amount of carbonic acid converted in the component (A) and the content of the component (B) is 0.9 or less, and the pH value at 25 ℃ is 8.5 or more and 10.5 or less.
Description
Technical Field
The present invention relates to a liquid oral composition.
Background
Liquid oral compositions have been developed which can exert various properties such as an effect of removing tartar or tartar adhered to the tooth surface, an effect of preventing dental caries, an effect of removing colored stains, and the like. For example, patent document 1 discloses an oral cavity cleanser which is added with calcium ions, phosphate ions, or bicarbonate ions, has a pH of 8 or more and 12 or less, and has an improved biofilm removal effect by suppressing decalcification of dentin. Patent document 2 discloses an oral composition containing a flavorant, wherein a block copolymer type nonionic surfactant and an amphoteric surfactant are used in combination, and the pH is 8.0 or more, thereby solubilizing the flavorant and stabilizing the flavorant with time.
Further, patent document 3 discloses a whitening agent containing a carbonate salt such as sodium carbonate or sodium bicarbonate as a whitening component, which realizes safe and convenient tooth whitening.
(patent document 1) Japanese patent laid-open No. 2008-1657
(patent document 2) Japanese patent laid-open No. Hei 10-77217
(patent document 3) Japanese patent laid-open No. 2014-152166
Disclosure of Invention
The present invention relates to a liquid oral composition comprising the following components (a), (B) and (C):
(A) 1 or 2 or more carbonate salts selected from sodium bicarbonate, sodium carbonate, and sodium sesquicarbonate, in an amount of 0.1 to 2 mass% in terms of carbonic acid;
(B) 0.2 to 1.7% by mass of an anionic surfactant; and
(C) water in an amount of 60 to 99.5 mass%, and
the content of the polyvalent metal cation (D) is less than 0.1 times by mole relative to the component (A), the value ((A) × (B)) which is the product of the amount of carbonic acid equivalent to the component (A) and the content of the component (B) is 0.9 or less, and the pH at 25 ℃ is 8.5 or more and 10.5 or less.
It is known that various stains are mixed with colored stains adhering to the tooth surface due to daily diet or the like, and it is difficult to sufficiently remove such colored stains while maintaining a good feeling of use in a liquid oral composition by a simple application method of gargling in the oral cavity for a certain period of time.
Therefore, even the compositions described in patent documents 1 to 2 are difficult to sufficiently improve the removal effect of the colored stains, and even the composition described in patent document 3 is likely to have increased irritation to the gum or the oral mucosa and fail to provide a good feeling of use without harmfulness.
Accordingly, the present invention relates to a liquid oral composition which maintains a good feeling in use and has an excellent effect of removing colored stains.
In view of the above, the present inventors have made various studies and focused on the continuous supply of hydroxide ions (OH)-) Which greatly contributes to the removal of colored stains, it has been newly found that it is effective to use a specific carbonate having a buffering capacity as a supply source of the hydroxide ions. The present inventors have also found that a liquid oral composition which maintains a good feeling in use and has an excellent effect of removing colored stains can be obtained by using 1 or 2 or more kinds of carbonates selected from sodium bicarbonate, sodium carbonate, and sodium sesquicarbonate and an anionic surfactant together in the presence of a specific amount of water so as to represent a specific amount and a specific product, respectively, and adjusting the content of polyvalent metal cations to a specific alkaline pH range while limiting the content.
According to the liquid oral composition of the present invention, it is possible to effectively prevent the manifestation of harmfulness due to, for example, increased irritation to the gum or the mucous membrane in the oral cavity and the deterioration of flavor due to, for example, bitterness, simply by rinsing in the oral cavity, to maintain a good feeling of use, and to effectively remove colored stains that are firmly attached to the tooth surface due to, for example, daily eating.
Detailed Description
The present invention will be described in detail below.
The liquid oral composition of the present invention contains 1 or 2 or more carbonate salts selected from sodium bicarbonate, sodium carbonate, and sodium sesquicarbonate as the component (a). These carbonates have buffering ability and can also be used as a pH adjuster, and in the present invention, these can be used as component (a) selected from 1 of sodium bicarbonate, sodium carbonate, and sodium sesquicarbonate, and more preferably contain a compound selected from sodium bicarbonate and sodium carbonate; and carbonate in sodium sesquicarbonate. The sodium carbonate is selected from sodium bicarbonate and sodium carbonate; and carbonate in sodium sesquicarbonate means using a mixture of sodium bicarbonate and sodium carbonate; or sodium sesquicarbonate alone; or sodium bicarbonate, sodium carbonate, and sodium sesquicarbonate may be used. By using the component (a), the buffering capacity of each component can be sufficiently exhibited, hydroxide ions can be continuously supplied into the oral cavity, the pH can be adjusted to a specific alkaline region as described later, the feeling of use is good, and the effect of effectively removing colored dirt adhering to the tooth surface and the like can be sufficiently exhibited. As the component (a), from the viewpoint of enhancing the effect of removing colored stains, it is preferable to use sodium bicarbonate and sodium carbonate in combination.
The content of the component (a) is carbonic acid (H) in the liquid oral composition of the present invention from the viewpoint of ensuring a high removal effect of colored stains2CO3) The content is 0.1 mass% or more, preferably 0.15 mass% or more, more preferably 0.18 mass% or more, and still more preferably 0.20 mass% or more in terms of amount. The content of the component (a) is 2 mass% or less, preferably 1.5 mass% or less, more preferably 1.3 mass% or less, even more preferably 1.0 mass% or less, and even more preferably 0.6 mass% or less in terms of carbonic acid in the liquid oral composition of the present invention, from the viewpoint of suppressing the hazard of the composition to the gum or the oral mucosa, and the viewpoint of ensuring the flavor. The content of the component (a) in the liquid oral composition of the present invention is 0.1 to 2 mass%, preferably 0.15 to 1.5 mass%, more preferably 0.18 to 1.3 mass%, even more preferably 0.20 to 1.0 mass%, and even more preferably 0.20 to 0.6 mass%, in terms of carbonic acid.
The liquid oral composition of the present invention contains 0.2 to 1.7% by mass of an anionic surfactant as component (B). By containing the component (B) in such an amount, the effect of removing colored dirt obtained by the component (a) can be synergistically enhanced, and the appearance of harmfulness or the like can be effectively prevented, so that a good feeling of use can be maintained.
Examples of the component (B) include: 1 or more than 2 kinds selected from alkyl sulfate salt such as alkyl sodium sulfate, acyl amino acid salt such as acyl sodium glutamate and acyl sodium sarcosinate, N-methyl long-chain acyl sodium taurate such as lauryl methyl sodium taurate, alkyl phosphate such as alkyl sodium phosphate, higher fatty acid sulfonated monoglyceride salt, fatty acid ester salt of isethionic acid, and polyoxyethylene monoalkyl phosphate. Among them, from the viewpoint of achieving both a high effect of removing colored dirt and a good feeling in use, 1 or 2 or more selected from sodium alkylsulfate, sodium acylglutamate and sodium lauryl methyl taurate are preferable, and at least sodium alkylsulfate is more preferably contained, and sodium alkylsulfate and the other component (B) are more preferably used in combination.
Specific examples of the sodium alkylsulfate include: the sodium alkyl sulfate having a saturated or unsaturated alkyl group having 8 to 18 carbon atoms is preferably sodium alkyl sulfate having a saturated or unsaturated alkyl group having 10 to 14 carbon atoms from the viewpoint of solubility, manufacturability and feeling of use, more specifically, 1 or 2 kinds selected from sodium lauryl sulfate and sodium myristyl sulfate are more preferable, and sodium lauryl sulfate is still more preferable.
The content of the component (B) is 0.2% by mass or more, preferably 0.4% by mass or more, and more preferably 0.5% by mass or more in the liquid oral composition of the present invention, from the viewpoint of effectively improving the removal effect of colored stains. The content of the component (B) is 1.7% by mass or less, preferably 1.6% by mass or less, more preferably 1.5% by mass or less, even more preferably 1.2% by mass or less, and even more preferably 1.0% by mass or less in the liquid oral composition of the present invention, from the viewpoint of effectively suppressing the risk of damage to the gum or oral mucosa, and from the viewpoint of maintaining a good flavor. The content of the component (B) in the liquid oral composition of the present invention is 0.2 to 1.7% by mass, preferably 0.4 to 1.6% by mass, more preferably 0.5 to 1.5% by mass, even more preferably 0.5 to 1.2% by mass, and even more preferably 0.5 to 1.0% by mass.
The value ((a) × (B)) of the product of the carbonic acid equivalent amount of the component (a) and the content of the component (B) is 0.9 or less, preferably 0.8 or less, more preferably 0.5 or less, even more preferably 0.4 or less, and preferably 0.08 or more, more preferably 0.10 or more, from the viewpoint of effectively achieving both a high removal effect of colored dirt and a good feeling of use obtained by suppressing the hazard or the like. The value ((A) × (B)) of the product of the amount of carbonic acid converted in the component (A) and the content of the component (B) is 0.9 or less, preferably 0.08 to 0.9, more preferably 0.08 to 0.8, still more preferably 0.10 to 0.5, and still more preferably 0.10 to 0.4. Here, the product of the carbonic acid equivalent amount of the component (a) and the content of the component (B) is a product of numerical values expressed by mass% in 100 mass% of each composition.
The component (a) has a characteristic that the pH of the liquid oral composition may exceed a specific alkaline range or the flavor may be reduced as the equivalent amount of carbonic acid increases, and the component (B) has a characteristic that the component (a) may be easily expressed as hazardous property or the like and the flavor may be lost to reduce the feeling of use as the content thereof increases. The present inventors have found, after referring to the various properties of the component (a) and the component (B), that it is very effective to contain the component (a) and the component (B) in the above-mentioned specific amounts and to make the value ((a) × (B)) of the product of these contents fall within the above-mentioned specific range in the liquid oral composition in terms of ensuring both the excellent removal effect of colored stains and the good feeling of use.
The total amount of the carbonic acid equivalent amount of the component (a) and the content of the component (B) is preferably 0.5% by mass or more, more preferably 0.55% by mass or more, even more preferably 0.7% by mass or more, and even more preferably 0.75% by mass or more in the liquid oral composition of the present invention, from the viewpoint of effectively improving the removal effect of colored stains. The total amount of the component (a) in terms of carbonic acid and the component (B) is preferably 2.4% by mass or less, more preferably 2.2% by mass or less, even more preferably 2.0% by mass or less, and even more preferably 1.6% by mass or less in the liquid oral composition of the present invention, from the viewpoint of effectively suppressing the harm to the gums and oral mucosa and the like, and from the viewpoint of maintaining a good flavor. The total amount of the component (a) in terms of carbonic acid and the component (B) is preferably 0.5 to 2.4% by mass, more preferably 0.55 to 2.2% by mass, even more preferably 0.7 to 2.0% by mass, and even more preferably 0.75 to 1.6% by mass in the liquid oral composition of the present invention.
The liquid oral composition of the present invention contains water in an amount of 60 to 99.5% by mass as component (C). The water as the component (C) in the present invention refers to the total moisture contained in the liquid oral composition, and includes not only purified water or ion exchange water blended in the liquid oral composition but also moisture contained in each blended component. By the water containing the component (C), the respective components can be dispersed or dissolved well, and the liquid oral composition can be spread well to every corner in the oral cavity even in use, thereby exhibiting an excellent effect of removing colored stains. Further, if the content of water is less than 60% by mass, the oral composition such as dentifrice is likely to be unevenly distributed in a specific portion of the oral cavity, and therefore only a local effect can be obtained, and it is preferable that the oral composition of the present invention be easily applied to the whole oral cavity by gargling in the oral cavity for a certain period of time, while keeping the contents of the respective components as constant as possible, from the viewpoint of obtaining a desired effect over the whole oral cavity or from the viewpoint of obtaining a desired effect over the whole oral cavity even if diluted with saliva.
The content of the component (C) is 60 mass% or more, preferably 65 mass% or more, and more preferably 70 mass% or more in the liquid oral composition of the present invention, from the viewpoint of well dispersing or dissolving each component. The content of the component (C) is 99.5% by mass or less, preferably 99.2% by mass or less, and more preferably 99.15% by mass or less in the liquid oral composition of the present invention, from the viewpoint of ensuring an excellent effect of removing colored stains. The content of the component (C) in the liquid oral composition of the present invention is 60 to 99.5 mass%, preferably 65 to 99.2 mass%, and more preferably 70 to 99.15 mass%.
The content of the polyvalent metal cation (D) in the liquid oral composition of the present invention is less than 0.1-fold mol relative to the component (a). In the liquid oral composition of the present invention, the polyvalent metal cation may not dissolve the component (a) or the like or may reduce the effect of removing colored stains, and therefore, the content thereof needs to be limited. The total content of the polyvalent metal cations is measured by ICP emission spectrometry (ICP emission spectrometer: Perkin Elmer, Optima5300DV), and the content is preferably less than 0.1 mol and preferably 0.02 mol or less in terms of carbonic acid relative to the component (A). Therefore, in the liquid oral composition of the present invention, it is desirable that the liquid oral composition does not contain a component that supplies polyvalent metal cations such as aluminum, calcium, magnesium, iron, and zinc, and may contain no polyvalent metal cations except for the case where mixing is unavoidable. Further, if the polyvalent metal cation is a polyvalent metal-containing component, the effect of the present invention obtained by the component (a) tends to be reduced even if, for example, the polyvalent metal cation is an insoluble polyvalent metal salt and is present in the composition in the form of particles. For example, even in the case of an abrasive powder such as aluminum hydroxide, aluminum ions are supplied to the liquid oral composition. Therefore, when the liquid oral composition of the present invention contains a polyvalent metal salt, it is considered that the colored stain-removing performance obtained by the component (a) is lowered because a cation is gradually supplied in a trace amount to the moisture contained in the liquid oral composition or the component (a) is adsorbed by the contact of the polyvalent metal salt with the component (a).
In the present specification, the term "particulate body" is a general term for an abrasive powder and a particle, and refers to an abrasive powder and a particle having a particle size of 5 to 800 μm in average diameter. In the liquid oral composition of the present invention, the granules inhibit: from the viewpoint of insolubilizing the component (a) and the like or reducing the effect of removing colored dirt, the content thereof is preferably limited.
The abrasive powder is a powder that can function as a polishing agent, and specific examples of the abrasive powder include, in addition to the aluminum hydroxide: dicalcium phosphate, tricalcium phosphate, insoluble sodium metaphosphate, magnesium phosphate, calcium carbonate, calcium pyrophosphate, composite aluminosilicate and the like.
The particles are aggregates obtained by granulating a specific material, and examples of the material include light calcium carbonate, heavy calcium carbonate, zeolite, dicalcium phosphate, tricalcium phosphate, insoluble sodium metaphosphate, aluminum hydroxide, magnesium phosphate, calcium pyrophosphate, magnesium carbonate, magnesium aluminum silicate, synthetic aluminum silicate, calcium silicate, bentonite, montmorillonite, kaolin, aluminum hydroxide gel, alumina sol, synthetic hydrotalcite, magnesium carbonate, magnesium oxide, magnesium hydroxide, and higher fatty acid salts such as magnesium stearate and calcium stearate.
The total content of the particulate matter selected from the abrasive powder and the particles in the liquid oral composition of the present invention is preferably 1% by mass or less, more preferably 0.2% by mass or less, and even more preferably 0.1% by mass or less, and the liquid oral composition of the present invention preferably does not contain the particulate matter.
In the liquid oral composition of the present invention, the pH adjuster (E) other than the component (a), that is, the pH adjuster (E) selected from the group consisting of the amino acid (E-1), the alkali metal hydroxide (E-2), the organic acid or a salt thereof (E-3) other than the component (E-1), the inorganic acid or a salt thereof (E-4) other than the component (E-2), and urea is specifically different depending on the kind thereof, and the buffering capacity of the component (a) may be lowered depending on the case, and the following adjustment to a specific alkaline pH range may be difficult, and therefore, it is preferable to limit the content thereof. That is, the content of the component (E) is preferably 20 parts by mass or less, more preferably 15 parts by mass or less, and still more preferably 10 parts by mass or less, based on 100 parts by mass of the component (a) in terms of carbonic acid. Since the pH adjuster (E) is somewhat different depending on its kind, the specific content to be limited also differs depending on its kind.
Specific examples of the amino acid (e-1) include: basic amino acids such as arginine and lysine, and acidic amino acids such as aspartic acid. In the component (e-1), the content of the basic amino acid may be, for example, a sugar alcohol such as sorbitol for the purpose of improving the flavor, stability, or the like, and may cause yellowing, or may form an unnecessary salt together with the component (a), and therefore, from the viewpoint of effectively avoiding such yellowing, the content is preferably 5 parts by mass or less, more preferably 3 parts by mass or less, even more preferably 1 part by mass or less, and further preferably does not contain the basic amino acid, based on 100 parts by mass of the carbonate equivalent of the component (a).
As the alkali metal hydroxide (e-2), specifically, there can be mentioned: sodium hydroxide, potassium hydroxide. The content of the component (e-2) is preferably 10 parts by mass or less, more preferably 5 parts by mass or less, even more preferably 3 parts by mass or less, even more preferably 1 part by mass or less, and preferably no component (e-2) from the viewpoint of suppressing the influence on the flavor or the harmfulness due to the increase in pH, or from the viewpoint of suppressing the decrease in the performance of removing colored stains due to the decrease in the buffering capacity of the component (a), and from the viewpoint of facilitating the adjustment to a specific alkaline pH range described below, relative to 100 parts by mass of the carbonate equivalent amount of the component (a). The content of the component (e-2) is calculated from the amount of the component (a) to be blended estimated from the amount of the component (a) in the composition converted to carbonic acid, the amounts of sodium and potassium in the composition, and the pH value in the case where the amount to be blended is clear.
Specific examples of the organic acid or a salt thereof (e-3) include: citric acid, malic acid, lactic acid, tartaric acid, succinic acid, acetic acid, glycerophosphoric acid, gluconic acid, fumaric acid, phytic acid, or salts of these. Examples of the salt include: potassium salt, sodium salt, ammonium salt.
The content of the component (e-3) in the liquid oral composition of the present invention is preferably 20 parts by mass or less, more preferably 15 parts by mass or less, and still more preferably 10 parts by mass or less, based on 100 parts by mass of the carbonic acid equivalent of the component (a), from the viewpoint of facilitating the adjustment to the specific alkaline pH range described below. The component (e-3) may be contained in an amount of 5 parts by mass or more per 100 parts by mass of the component (A) in terms of carbonic acid.
Specific examples of the inorganic acid or a salt thereof (e-4) include orthophosphoric acid or a salt thereof, and further include: condensed phosphoric acids selected from pyrophosphoric acid, tripolyphosphoric acid, or hexametaphosphoric acid, or salts thereof. Further, as the inorganic acid (e-4) other than the orthophosphoric acid, the condensed phosphoric acid and the salts thereof, there may be mentioned: hydrochloric acid, sulfuric acid, nitric acid, and sulfonic acid or salts of these.
In the component (e-4), the content of orthophosphoric acid, condensed phosphoric acid, or a salt thereof is preferably 20 parts by mass or less, more preferably 15 parts by mass or less, per 100 parts by mass of the carbonic acid equivalent of the component (a), from the viewpoint of providing a good feeling in use and ensuring a high performance of removing colored stains. The content of orthophosphoric acid, condensed phosphoric acid, and salts thereof is preferably 3 parts by mass or more, more preferably 5 parts by mass or more, and even more preferably 7 parts by mass or more per 100 parts by mass of the component (a) in terms of carbonic acid equivalent in terms of removal performance of colored stains and organic stains.
In the component (e-4), the content of orthophosphoric acid such as hydrochloric acid or sulfuric acid, condensed phosphoric acid, and a component (e-4) other than these salts is preferably 5 parts by mass or less, more preferably 3 parts by mass or less, and even more preferably 1 part by mass or less, per 100 parts by mass of the carbonic acid equivalent of the component (a), and the component (e-4) other than orthophosphoric acid, condensed phosphoric acid, and these salts is preferably not contained, from the viewpoint of not inhibiting the adjustment to the specific alkaline pH region described below.
Further, urea is cited as another pH adjuster (E), and the content of urea is preferably 5 parts by mass or less, more preferably 3 parts by mass or less, further preferably 1 part by mass or less, and preferably does not contain urea, with respect to 100 parts by mass of the carbonate equivalent amount of the component (a), from the viewpoint of not inhibiting the adjustment to the specific alkaline pH range described below.
In the liquid oral composition of the present invention, the nonionic surfactant (F) is preferably contained in a limited amount from the viewpoint of enhancing the effect of removing colored stains and the viewpoint of suppressing the increase in the harmfulness. Examples of the nonionic surfactant as the component (F) include: selected from polyoxyethylene hydrogenated castor oil; sucrose fatty acid ester; sorbitan fatty acid esters; glycerin fatty acid esters such as glycerin monostearate; an alkyl glucoside; polyglyceryl fatty acid esters such as polyglyceryl-10 monostearate and polyglyceryl-10 monomyristate; polyoxyethylene alkylphenyl ethers such as polyoxyethylene monoalkyl (or alkenyl) ethers, polyoxyethylene polyoxypropylene copolymers, polyoxyethylene nonylphenyl ethers and the like; an amine oxide surfactant; fatty acid alkanolamides such as coconut oil fatty acid diethanolamide; and 1 or more than 2 of polyethylene glycol fatty acid esters. Specifically, the content of the component (F) in the liquid oral composition of the present invention is preferably 1% by mass or less, more preferably 0.5% by mass or less, even more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less, and the liquid oral composition of the present invention preferably does not contain the nonionic surfactant (F).
In the liquid oral composition of the present invention, it is preferable to limit the content of a disinfectant selected from peroxide and chlorine dioxide from the viewpoint of maintaining an excellent effect of removing colored stains, suppressing excessive irritation in the oral cavity and ensuring a good feeling of use, and from the viewpoint of suppressing increase in harmfulness. Specifically, the total content of the disinfectant in the liquid oral composition of the present invention is preferably 0.1% by mass or less, more preferably 0.01% by mass or less, and the liquid oral composition of the present invention preferably does not contain a disinfectant selected from peroxide and chlorine dioxide.
The liquid oral composition of the present invention may contain, in addition to the above components, for example, a surfactant other than the anionic surfactant and the nonionic surfactant of the component (B), sugar alcohol, a flavor, a preservative, a binder, a pigment, a coloring matter, and the like, within a range not to impair the effects of the present invention.
Examples of the surfactant other than the anionic surfactant and the nonionic surfactant of the component (B) include: acetic acid betaines such as lauryl dimethyl glycine betaine; imidazolium betaines such as 2-alkyl-N-carboxymethyl-N-hydroxyethyl-N-imidazolium betaine; alkyl sulfobetaines such as lauryl sulfobetaine and lauryl hydroxysulfobetaine; coconut oil fatty acid amide alkyl betaines such as coconut oil fatty acid amide propyl betaine; long chain alkyl imidazoline betaine salts such as N-alkyl-1-hydroxyethyl imidazoline betaine sodium.
Examples of sugar alcohols include: sorbitol, erythritol, xylitol, lactitol, reduced palatinose, maltitol.
The perfume may be any one that exhibits oil solubility, and examples thereof include: peppermint oil (peppermint oil), spearmint oil, cinnamon oil (cinmamon oil), anise oil, eucalyptus oil, wintergreen oil, cinnamon oil (cassia oil), clove oil, thyme oil, sage oil (sageoil), clary sage oil (sage clary oil), nutmeg oil, anise oil, lemon oil, sweet orange oil, peppermint oil, cardamom oil, coriander oil, basil oil, tangerine oil, lime oil, lavender oil, rosemary oil, ginger oil, grapefruit oil, bay oil (laurel oil), chamomile oil (chamomile oil), caraway oil (caraway oil), marjoram oil, geranium oil (bay oil), lemon grass oil, lemon mint oil (lemon palm oil), pimento oil (pimento oil), pine needle oil (pine needle oil), jasmine oil (jasmine oil), rose oil (jasmine oil), natural jasmine oil (jasmine oil), orange oil (rose oil, orange oil, rose oil, natural peppermint oil (rose oil), rose oil (rose oil, rose oil (jasmine oil), lemon oil (rosemary oil, lemon oil, olive, And perfume components obtained by processing these natural perfume components; menthol, menthol longifol (pulegol), carvone, anethole, eucalyptol (cineole), methyl salicylate, cinnamaldehyde, eugenol, 3-1-menthoxypropane-1, 2-diol, thymol (thymol), citronellyl acetate, linalool acetate, geraniol, geranyl acetate, citronellol, limonene, menthone, menthyl acetate, N-substituted-p-menthane-3-carboxamide, pinene, octanal, citral, pulegone, carvacrol acetate, dihydrocarvacrol acetate, anisic aldehyde (anisaldehydide), benzaldehyde, camphor, a lactone, ethyl acetate, ethyl butyrate, allyl cyclohexylpropionate, methyl anthranilate, ethyl methylphenylglycidate, vanillin, undecanoate, hexanal, butyl acetate, isoamyl acetate, hexenol acetate, Single perfume ingredients such as dimethyl sulfide, methylcyclopentadiene (cyclotene), furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethyl thioglycolate and the like; flavoring ingredients such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, cream flavor, cow milk flavor, fruit mix flavor, tropical fruit flavor, etc.
Examples of the preservative include: isobutyl p-hydroxybenzoate, isopropyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, butyl p-hydroxybenzoate, propyl p-hydroxybenzoate, methyl p-hydroxybenzoate, benzoic acid, sodium benzoate, methyl salicylate, potassium sorbate and sodium dehydroacetate.
Examples of the binder include: sodium alginate, carboxymethyl cellulose or its salt, carrageenin, xanthan gum, sodium polyacrylate, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, acacia gum, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, sodium chondroitin sulfate, and methoxyethylene-maleic anhydride copolymer.
The pH of the liquid oral composition of the present invention at 25 ℃ is 8.5 or more, preferably 9 or more, more preferably more than 9, and even more preferably 9.5 or more, from the viewpoint of ensuring a high stain-removing effect that the component (a) and the component (B) supplement each other and exert. The liquid oral composition of the present invention has a pH value of 10.5 or less, preferably 10 or less, from the viewpoint of effectively suppressing the appearance of harmfulness and maintaining a good flavor while ensuring a high feeling of use at 25 ℃. The liquid oral composition of the present invention has a pH value of 8.5 or more and 10.5 or less, preferably 9 to 10, more preferably more than 9 and 10 or less, and still more preferably 9.5 to 10 at 25 ℃.
The liquid oral composition of the present invention is preferably a liquid oral composition in which the components (a) and (B) are dissolved or dispersed in water as the component (C), and is preferably a transparent liquid oral composition, from the viewpoint of further improving the effect of the present invention. In the present invention, transparent or translucent means that the transmittance of a cuvette having an optical path length of 10mm, which absorbs light having a wavelength of 550nm, is 80% or more, preferably 90% or more, more preferably 95% or more, and may be transparent in color or colorless. The transmittance was measured with an ultraviolet-visible spectrophotometer having a wavelength of 550nm, for example, a "UV-2500 PC type measuring instrument" manufactured by Shimadzu corporation, using a quartz cuvette having an optical path length of 1 mm.
The liquid oral composition of the present invention can be applied to a mouthwash, a liquid dentifrice, a water dentifrice, an oral spray, a gargle, and the like, can be applied to a dentifrice sheet obtained by impregnating a sheet with the liquid oral composition of the present invention, can be filled in a foam-discharging container to be discharged in a foam form as a foam inhibitor, and can be used as a liquid agent to be applied to the oral cavity.
For example, when the liquid oral composition of the present invention is a mouthwash, a liquid dentifrice or a foam inhibitor, the composition is preferably used by being applied 1 to 5 times in the oral cavity for 1 day, and for example, the composition is preferably used by gargling 5 to 100mL, more preferably 10 to 50mL in the oral cavity. The time for gargling in the oral cavity is preferably 10 seconds to 5 minutes, more preferably 20 seconds to 3 minutes, and still more preferably 30 seconds to 1 minute. For example, when the liquid oral composition of the present invention is applied to a dentifrice sheet, the wet sheet is wrapped around a finger and rubbed against the surface of the tooth, thereby removing the dirt from the tooth.
The liquid oral composition of the present invention can be obtained by a production method comprising the steps of mixing 0.2 to 3 mass% carbonate of component (a), 0.2 to 1.7 mass% anionic surfactant of component (B), and 70 to 99.5 mass% water of component (C) in terms of carbonic acid, and adjusting the pH to 8.5 to 10.5.
As described above, the component (a) is 1 or 2 or more carbonate salts selected from sodium bicarbonate, sodium carbonate, and sodium sesquicarbonate, and any one of a mixture of sodium bicarbonate and sodium carbonate, sodium sesquicarbonate alone, or sodium bicarbonate, sodium carbonate, and sodium sesquicarbonate in total may be blended so that the total amount calculated as the amount of carbonic acid falls within the above range and the pH value falls within the above range.
The amounts of the components (a) to (C) are the same as the above contents, and the amounts of other components used as necessary are also the same as the above contents. The order of blending these components is not particularly limited, and the liquid oral composition of the present invention can be obtained by a mixing step after the blending step.
The following liquid oral composition and a method for producing the same are further disclosed with respect to the above-described embodiments of the present invention.
[1] A liquid oral composition comprising the following components (A), (B) and (C):
(A) 1 or 2 or more carbonate salts selected from sodium bicarbonate, sodium carbonate, and sodium sesquicarbonate, in an amount of 0.1 to 2 mass% in terms of carbonic acid;
(B) 0.2 to 1.7% by mass of an anionic surfactant; and
(C) water in an amount of 60 to 99.5 mass%, and
the content of the polyvalent metal cation (D) is less than 0.1 times mole relative to the component (A), and the value ((A) × (B)) which is the product of the amount of carbonic acid equivalent to the component (A) and the content of the component (B) is 0.9 or less, and
the pH value at 25 ℃ is 8.5 or more and 10.5 or less.
[2]As described above [1]The liquid oral composition of (1), wherein the content of the component (A) is carbonic acid (H)2CO3) In terms of amount, it is preferably 0.15% by mass or more, more preferably 0.18% by mass or more, even more preferably 0.20% by mass or more, and preferably 1.5% by mass or less, more preferably 1.3% by mass or less, even more preferably 1.0% by mass or less, even more preferably 0.6% by mass or less.
[3] The liquid oral composition according to the above [1] or [2], wherein the component (A) is a carbonate selected from a mixture of sodium hydrogencarbonate and sodium carbonate and sodium sesquicarbonate.
[4] The liquid oral composition according to any one of the above [1] to [3], wherein the component (B) is preferably 1 or 2 or more selected from sodium alkylsulfates, sodium acylglutamates and sodium lauryl methyl taurate, and more preferably contains at least sodium alkylsulfates.
[5] The liquid oral composition according to any one of the above [1] to [4], wherein the content of the component (B) is preferably 0.4% by mass or more, more preferably 0.5% by mass or more, and preferably 1.6% by mass or less, more preferably 1.5% by mass or less, further preferably 1.2% by mass or less, further more preferably 1.0% by mass or less.
[6] The liquid oral composition according to any one of [1] to [5] above, wherein the value ((A) × (B)) of the product of the amount of carbonic acid converted of the component (A) and the content of the component (B) is preferably 0.8 or less, more preferably 0.5 or less, still more preferably 0.4 or less, and preferably 0.08 or more, more preferably 0.10 or more.
[7] The liquid oral composition according to any one of [1] to [6], wherein the total amount of the carbonic acid equivalent amount of the component (A) and the content of the component (B) is preferably 0.5% by mass or more, more preferably 0.55% by mass or more, further preferably 0.7% by mass or more, further preferably 0.75% by mass or more, and preferably 2.4% by mass or less, more preferably 2.2% by mass or less, further preferably 2.0% by mass or less, further more preferably 1.6% by mass or less.
[8] The liquid oral composition according to any one of the above [1] to [7], wherein the content of the component (C) is preferably 65% by mass or more, more preferably 70% by mass or more, and preferably 99.2% by mass or less, more preferably 99.15% by mass or less.
[9] The liquid oral composition according to any one of the above [1] to [8], wherein the content of the polyvalent metal cation (D) is preferably 0.02 times by mol or less in terms of carbonic acid of the component (A).
[10] The liquid oral composition according to any one of [1] to [9], wherein the content of the pH adjustor (E) other than the component (A) is preferably 20 parts by mass or less, more preferably 15 parts by mass or less, and still more preferably 10 parts by mass or less, per 100 parts by mass of the component (A) in terms of carbonic acid.
[11] The liquid oral composition according to any one of the above [1] to [10], wherein the pH adjuster (E) other than the component (A) is a pH adjuster selected from the group consisting of an amino acid (E-1), an alkali metal hydroxide (E-2), an organic acid or a salt thereof (E-3) other than the component (E-1), an inorganic acid or a salt thereof (E-4) other than the component (E-2), and urea.
[12] The liquid oral composition according to any one of the above [1] to [11], wherein the content of the basic amino acid in the amino acid (e-1) is preferably 5 parts by mass or less, more preferably 3 parts by mass or less, and still more preferably 1 part by mass or less, based on 100 parts by mass of the carbonic acid equivalent of the component (A), or does not contain the basic amino acid.
[13] The liquid oral composition according to any one of the above [1] to [12], wherein the content of the alkali metal hydroxide (e-2) is preferably 10 parts by mass or less, more preferably 5 parts by mass or less, further preferably 3 parts by mass or less, further more preferably 1 part by mass or less, or does not contain the component (e-2) based on 100 parts by mass of the carbonic acid equivalent to the component (A).
[14] The liquid oral composition according to any one of the above [1] to [13], wherein the content of the organic acid or a salt thereof (e-3) is preferably 20 parts by mass or less, more preferably 15 parts by mass or less, even more preferably 10 parts by mass or less, and may be 5 parts by mass or more, based on 100 parts by mass of the component (A) in terms of carbonic acid.
[15] The liquid oral composition according to any one of [1] to [14], wherein the content of the orthophosphoric acid, the condensed phosphoric acid, or the salt thereof in the inorganic acid or the salt thereof (e-4) is preferably 20 parts by mass or less, more preferably 15 parts by mass or less, and preferably 3 parts by mass or more, more preferably 5 parts by mass or more, and further preferably 7 parts by mass or more, based on 100 parts by mass of the carbonic acid equivalent of the component (A).
[16] The liquid oral composition according to any one of the above [1] to [15], wherein the content of the nonionic surfactant (F) is preferably 1% by mass or less, more preferably 0.5% by mass or less, further preferably 0.2% by mass or less, further preferably 0.1% by mass or less, or does not contain the nonionic surfactant (F).
[17] The liquid oral composition according to any one of the above [1] to [16], wherein the total content of the particulate matter selected from the abrasive powder and the abrasive granules is preferably 1% by mass or less, more preferably 0.2% by mass or less, and even more preferably 0.1% by mass or less, or no particulate matter is contained.
[18] The liquid oral composition according to any one of the above items [1] to [17], wherein the total content of the disinfectant selected from the peroxide and the chlorine dioxide is preferably 0.1% by mass or less, more preferably 0.01% by mass or less, or the disinfectant selected from the peroxide and the chlorine dioxide is not contained in the liquid oral composition of the present invention.
[19] The liquid oral composition according to any one of the above [1] to [18], wherein the pH at 25 ℃ is preferably 9 or more, more preferably more than 9, further preferably 9.5 or more, and preferably 10 or less.
[20] The liquid oral composition according to any one of the above [1] to [19], wherein the liquid oral composition is a mouthwash, a liquid dentifrice, an aqueous dentifrice, an oral spray or a gargle; or a foam control agent which is filled in the foam discharge container and discharged in a foam state.
[21] Use of the liquid oral composition according to any one of the above [1] to [19] for producing a mouthwash, a liquid dentifrice, a water dentifrice, an oral spray, or a gargle, or for producing a foam inhibitor which is filled in a foam-discharging container and discharged in a foam form.
[22] Use of the liquid oral composition of any one of the above [1] to [19] for removing stained stains from teeth.
[23] Use of the liquid oral composition according to any one of the above [1] to [19] for application in the oral cavity.
[24] A method for producing the liquid oral composition according to any one of [1] to [19], which comprises a step of blending the following components (A), (B) and (C):
(A) 1 or 2 or more carbonate salts selected from sodium bicarbonate, sodium carbonate, and sodium sesquicarbonate, in an amount of 0.1 to 2 mass% in terms of carbonic acid;
(B) 0.2 to 1.7% by mass of an anionic surfactant;
(C) 70 to 99.5% by mass of water.
[25] The liquid oral composition according to any one of the above [1] to [19], wherein the liquid oral composition is obtained by blending the following components (A), (B) and (C):
(A) 1 or 2 or more carbonate salts selected from sodium bicarbonate, sodium carbonate, and sodium sesquicarbonate, in an amount of 0.1 to 2 mass% in terms of carbonic acid;
(B) 0.2 to 1.7% by mass of an anionic surfactant; and
(C) 70 to 99.5% by mass of water.
[ examples ]
The present invention will be specifically described below based on examples. Unless otherwise specified in the table, the content of each component represents mass%.
Examples 1 to 16 and comparative examples 1 to 9
Liquid oral compositions were prepared according to the formulations shown in tables 1 to 2. The colored soil removal effect, flavor, and haziness were evaluated by the following methods. The liquid oral compositions of examples 1 to 16 and comparative examples 1 to 9 contained the polyvalent metal cation in an amount of 0.02 times by mol or less based on the component (A).
The results are shown in tables 1 to 2.
Evaluation of colored dirt removing Effect
The HAP plate (HOYA, APP-100) used in the test was ground with a grinding paper (#400), immersed in 0.1N hydrochloric acid for 30 seconds to be subjected to acid treatment, and then washed 3 times with 1mL of water. Then, the HAP plate was immersed in 40mL of a 1% bovine serum albumin solution (BSA, manufactured by wako pure chemical industries), 40mL of artificial saliva, and 40mL of a black tea solution for 5 minutes, and then dried. After repeating these steps 15 times, the b value (b value before immersion) was measured by using a spectrophotometer (CM-700d, manufactured by Konica Minolta) in which the degree of coloration was expressed by L a b color system (munsell color).
Then, the resulting HAP plate was immersed in each liquid oral composition for 2 minutes, and then the b value (b value after immersion) was measured in the same manner, and the removal rate (%) of colored stains was calculated according to the following formula (X), and the value of comparative example 1 was expressed as an index with reference to 100.
Removal rate (%) - (before dipping b value-after dipping b value)/before dipping b value X100 · (X)
The artificial saliva used was an aqueous solution containing calcium chloride (1.0mM), potassium hydrogen phosphate (0.9mM), and HEPES (4- (2-hydroxyethyl) -1-piperazineethanesulfonic acid) (2.0mM), and was adjusted to pH 7 with potassium hydroxide. The black tea solution was prepared by extracting 6 tea bags (Ridong black tea) in 300mL of hot water for 5 minutes, and filtering the black tea solution cooled to room temperature. No.1 filter paper manufactured by WHATMAN was used for filtering the black tea solution.
Evaluation of flavor
The flavor perceived in the oral cavity after 20mL of each liquid oral composition was discharged by gargling in the oral cavity for 40 seconds was evaluated by 5 panelists according to the following criteria, and the evaluation results were obtained by negotiation.
A: has good taste
a: slightly bitter taste
B: feeling bitter
C: a strong bitter taste was felt
Evaluation of hazard
The harmfulness felt at the gum or the oral mucosa after 20mL of each liquid oral composition was discharged by gargling in the oral cavity for 40 seconds was evaluated by 5 panelists according to the following criteria, and the evaluation results were obtained by negotiation.
A: no stimulation was felt at all
a: slight feeling of stimulation
B: sense the stimulus
C: feeling strong stimulation
[ Table 2]
From the results shown in tables 1 to 2, it is apparent that the liquid oral compositions of examples 1 to 16 sufficiently exhibit both the effect of imparting a good feeling of use and the excellent effect of removing colored stains, compared with comparative example 1 containing no component (B), comparative examples 2 to 3 having a pH value outside the range of 8.5 to 10.5, comparative examples 4 to 5 having a content of component (B) or a carbonic acid equivalent amount of component (a) exceeding the above range, comparative examples 6 and 8 having a value of (a) × (B) of 0.9 or more, comparative example 7 using a nonionic surfactant in place of component (B), and comparative example 9 having a carbonic acid equivalent amount of component (a) or a pH value outside the above range.
[ comparative examples 10 to 11]
Each dentifrice was prepared according to the formulation shown in table 3. Then, the colored stain removing effect, flavor, and harmfulness were evaluated according to the above methods. From the viewpoint of bringing the dentifrice into uniform contact with HAP and from the viewpoint of diluting the dentifrice in the oral cavity, evaluation was made by using a liquid having fluidity diluted 4 times by purified water.
The pH at 25 ℃ was also measured after diluting 4-fold with purified water.
The results, including the liquid oral composition of example 4 above, are shown in table 3.
[ Table 3]
As can be understood from the results in table 3, even the dentifrice of comparative example 11, which contains a large amount of the component (a) and the component (B), does not have any problem in flavor or harmfulness, but does not sufficiently exhibit high coloring-removal performance as in the liquid oral compositions of examples 1 to 16.
Claims (21)
1. A liquid oral composition comprising, in admixture,
comprises the following components (A), (B) and (C):
(A) a carbonate selected from the group consisting of a mixture of sodium bicarbonate and sodium carbonate, and sodium sesquicarbonate, in an amount of 0.1 to 2 mass% in terms of carbonic acid;
(B) 0.2 to 1.7% by mass of an anionic surfactant; and
(C) water in an amount of 60 to 99.5 mass%, and
the content of the polyvalent metal cation (D) is less than 0.1 times by mole relative to the component (A), the value (A) × (B) of the product of the amount of carbonic acid converted of the component (A) and the content of the component (B) is 0.9 or less, the total amount of the amount of carbonic acid converted of the component (A) and the content of the component (B) is 0.75 to 2.025% by mass,
a pH value of 8.5 or more and 10.5 or less at 25 ℃ and
the content of the nonionic surfactant (F) was 0 mass%.
2. The liquid oral composition of claim 1,
the content of the pH adjuster (E) other than the component (a) is 20 parts by mass or less based on 100 parts by mass of the carbonate equivalent of the component (a).
3. The liquid oral composition of claim 1,
the component (B) is 1 or more than 2 selected from alkyl sodium sulfate, acyl sodium glutamate and sodium lauryl methyl taurate.
4. The liquid oral composition of any one of claims 1 to 3,
the pH adjustor (E) other than the component (A) is selected from the group consisting of an amino acid (E-1), an alkali metal hydroxide (E-2), an organic acid or a salt thereof (E-3) other than the component (E-1), an inorganic acid or a salt thereof (E-4), and urea.
5. The liquid oral composition of any one of claims 1 to 3,
the content of the alkali metal hydroxide (E-2) in the pH adjustor (E) other than the component (A) is 10 parts by mass or less based on 100 parts by mass of the carbonic acid equivalent of the component (A).
6. The liquid oral composition of any one of claims 1 to 3,
the component (B) contains at least sodium alkyl sulfate.
7. The liquid oral composition of any one of claims 1 to 3,
the value of the product of the amount of carbonic acid converted in the component (A) and the content of the component (B), wherein (A) × (B) is 0.08 to 0.8 inclusive.
8. The liquid oral composition of any one of claims 1 to 3,
the content of the component (a) is 0.15 mass% or more and 1.5 mass% or less in terms of carbonic acid.
9. The liquid oral composition of any one of claims 1 to 3,
the content of the component (B) is 0.4 to 1.5 mass%.
10. The liquid oral composition of any one of claims 1 to 3,
the content of the component (C) is 65 to 99.2 mass%.
11. The liquid oral composition of any one of claims 1 to 3,
the content of the polyvalent metal cation (D) is 0.02 times by mol or less based on the component (A).
12. The liquid oral composition of any one of claims 1 to 3,
the content of the basic amino acid in 1 type of amino acid (E-1) as the pH adjustor (E) other than the component (A) is 5 parts by mass or less based on 100 parts by mass of the carbonic acid equivalent amount of the component (A).
13. The liquid oral composition of any one of claims 1 to 3,
the content of 1 type of organic acid or a salt thereof (E-3) as the pH adjustor (E) other than the component (A) is 20 parts by mass or less based on 100 parts by mass of the carbonic acid equivalent amount of the component (A).
14. The liquid oral composition of any one of claims 1 to 3,
in 1 type of inorganic acid or salt thereof (E-4) as the pH adjustor (E) other than the component (A), the content of orthophosphoric acid, condensed phosphoric acid, and salt thereof is 20 parts by mass or less based on 100 parts by mass of the carbonic acid equivalent of the component (A).
15. The liquid oral composition of any one of claims 1 to 3,
the total content of particulate matter selected from the abrasive powder and the granules is 1 mass% or less.
16. The liquid oral composition of any one of claims 1 to 3,
the total content of the disinfectant selected from peroxide and chlorine dioxide is 0.1% by mass or less.
17. The liquid oral composition of any one of claims 1 to 3,
the pH value at 25 ℃ is 9 to 10 inclusive.
18. A gargle is prepared by mixing,
a liquid oral composition comprising any one of claims 1 to 17.
19. Use of a liquid oral composition according to any one of claims 1 to 17 for the manufacture of a mouthwash.
20. Use of the liquid oral composition according to any one of claims 1 to 17 as a foam control agent which is filled in a foam discharge container and discharged in a foam state.
21. A method for producing the liquid oral composition according to any one of claims 1 to 17, wherein,
comprising the step of blending the following components (A), (B) and (C):
(A) a carbonate selected from the group consisting of a mixture of sodium bicarbonate and sodium carbonate, and sodium sesquicarbonate, in an amount of 0.1 to 2 mass% in terms of carbonic acid;
(B) 0.2 to 1.7% by mass of an anionic surfactant; and
(C) 70 to 99.5% by mass of water.
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| PCT/JP2016/087068 WO2017104664A1 (en) | 2015-12-14 | 2016-12-13 | Liquid oral composition |
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| JP (1) | JP6742339B2 (en) |
| CN (1) | CN108289800B (en) |
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| WO2017104664A1 (en) | 2017-06-22 |
| TWI735490B (en) | 2021-08-11 |
| JP6742339B2 (en) | 2020-08-19 |
| JPWO2017104664A1 (en) | 2018-09-27 |
| CN108289800A (en) | 2018-07-17 |
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