CN108272652A - A kind of ceramide liposome and its preparation method and application - Google Patents

A kind of ceramide liposome and its preparation method and application Download PDF

Info

Publication number
CN108272652A
CN108272652A CN201810215403.6A CN201810215403A CN108272652A CN 108272652 A CN108272652 A CN 108272652A CN 201810215403 A CN201810215403 A CN 201810215403A CN 108272652 A CN108272652 A CN 108272652A
Authority
CN
China
Prior art keywords
ceramide
liposome
ceramide liposome
homogeneous
percentage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201810215403.6A
Other languages
Chinese (zh)
Other versions
CN108272652B (en
Inventor
任环宇
职蕾蕾
黄璐
沈丽
刘捷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Zhina Biotechnology Co.,Ltd.
Original Assignee
Laibo Cosmeceutical Technology (shanghai) Ltd By Share Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laibo Cosmeceutical Technology (shanghai) Ltd By Share Ltd filed Critical Laibo Cosmeceutical Technology (shanghai) Ltd By Share Ltd
Priority to CN201810215403.6A priority Critical patent/CN108272652B/en
Publication of CN108272652A publication Critical patent/CN108272652A/en
Application granted granted Critical
Publication of CN108272652B publication Critical patent/CN108272652B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14Liposomes; Vesicles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole

Abstract

The invention discloses a kind of ceramide liposomes and its preparation method and application.The ceramide liposome includes following component:Glycerine 5~50%, ethoxydiglycol 1~20%, ceramide 0.1~10% and phosphatidase 0 .5~30%, 100% is complemented to water;The wherein described phosphatide is lecithin and/or hydrolecithin, and the ceramide liposome does not include cholesterol;The percentage is the mass percent for accounting for ceramide liposome.Ceramide liposome stability prepared by the present invention is high, and good dispersion in water, grain size reaches 50~500nm of nanoscale;And production is convenient, using common homogeneous blender T25 Digital Package 1 (IKA).

Description

A kind of ceramide liposome and its preparation method and application
Technical field
The present invention relates to chemical fields, and in particular to a kind of ceramide liposome and its preparation method and application.
Background technology
Ceramide (Ceramride) is also known as sphingolipid (Sphingolipid), is to be present in a kind of fat in skin Matter plays an important role in epidermal keratinocytes layer formation process.Research in recent years shows drying, furfur, cracking occur when skin Phenomenon, when barrier function is substantially reduced, skin supplement ceramide can restore rapidly moisturizing and barrier function.It is right in view of its Skin specific function and curative effect, in recent years, ceramide also rapidly become domestic and international cosmetics company develop it is a kind of novel Superior cosmetics object active additive.
But ceramide is as dystectic oil soluble material, and the addition in cosmetics is in use, relatively difficult, especially In aqua product, it is difficult to using.Ceramide is made liposomal form, is on the one hand convenient for ceramide in cosmetic formulations Use, on the other hand can also improve the compatibility of ceramide and horn cell, provide ceramide with moisturizing, antiallergic and Maintenance and other effects.But poor dispersion in the stability and water of the ceramide liposome prepared at present, while needing using spy Different production equipment, being unfavorable for industrialized production, (Qin Dean, what learns the preparation method of people's ceramide liposome emulsions:CN: 98110614.5;Zhang Wanping, Tian Yonghong, Guo Yiguang wait a kind of Ceramide nanoemulsions of and preparation method thereof:, CN104739658A[P].2015;Xia Qiang thanks to a kind of Ceramide nanoemulsions of strong and preparation method thereof:,CN 103690391B[P].2016)。
There is an urgent need for the ceramide liposomes of good dispersion in a kind of stability height, water to make up the deficiencies in the prior art.
Invention content
The technical problem to be solved by the present invention is to overcome, stability existing for existing ceramide liposome is poor, in water Dispersed bad, industrialized production there are the defect of limitation, provide a kind of ceramide liposome and preparation method thereof and Using.Ceramide liposome stability provided by the invention is high, good dispersion in water, and preparation method is convenient, has good Industrial prospect.
There are certain technology barriers for the preparation of ceramide liposome in the prior art, such as:Liposome is micro- Grain, it is as high-pressure homogeneous in not having to, it is extremely difficult to Nano grade.The presence of the technology barrier not only increases ceramide liposome work The cost of industry metaplasia production, also prevents in the field and ceramide liposome is conducted further research and applied.The present invention Ethoxydiglycol is creatively applied to the preparation of ceramide liposome by people, instead of cholesterol customary in the art, The replacement of the raw material to prepare during ceramide liposome without using high pressure homogenizer, you can obtains Nano grade Liposome particle.
The present invention is to solve above-mentioned technical problem by following technical solution:
One of technical scheme of the present invention is:A kind of ceramide liposome comprising following component:Glycerine 5~50%, Ethoxydiglycol 1~20%, ceramide 0.1~10% and phosphatidase 0 .5~30%, 100% is complemented to water;Wherein institute It is lecithin and/or hydrolecithin to state phosphatide;The percentage is the mass percent for accounting for ceramide liposome.
Preferably, the ceramide liposome includes following component:Glycerine 10~30%, ethoxydiglycol 1~ 10%, ceramide 0.5~10% and phosphatidase 5~10% complement to 100% with water;The percentage is to account for ceramide The mass percent of liposome.
Lecithin isoreactivity ingredient is aoxidized in order to prevent, and the ceramide liposome further includes preferably anti-oxidant The content of agent, the antioxidant is preferably 0.1~1%, and the percentage is the mass percent for accounting for ceramide liposome; Wherein, the antioxidant can be the antioxidant of this field routine, preferably be selected from tocopherol (vitamin E), Vitamin C It is one or more in acid and its derivative;The derivative is selected from tocopherol acetate, ascorbic acid glucoside, Vitamin C It is one or more in sour palmitate and 3-O- ethylascorbyls.
The ceramide liposome further includes preferably antiseptic, and the content of the antiseptic is preferably 0.04~ 0.7%, more preferably 0.5%, the percentage are the mass percent for accounting for ceramide liposome.Wherein, the antiseptic It can be the antiseptic of this field routine, preferably be selected from parahydroxyacet-ophenone, hexylene glycol, hydroximic acid, pentanediol, Chlorphenesin With it is one or more in methyl hydroxybenzoate;More preferably, the ceramide liposome include parahydroxyacet-ophenone 0.5% and oneself two Alcohol 0.5% or decoyl hydroximic acid 0.05%, the percentage are the mass percent for accounting for ceramide liposome.
In order to enhance liposome moistening effect, the stability of liposome is improved, the ceramide liposome is preferably gone back Including helping moisturizer, described to help the content of moisturizer be preferably 5~8%, and further preferably 8%;The percentage is to account for god Mass percent through amide lipid body.Wherein, described to help moisturizer conventional for this field, preferably it is selected from mannose Alcohol, sorbierite, 1, it is one or more in 3 butanediols, propylene glycol and dipropyl glycol.
In order to improve the stability of liposome, the ceramide liposome further includes preferably assistant for emulsifying agent, described to help The content of emulsifier is preferably 0.5~2%, and more preferably 1%;The percentage is the quality percentage for accounting for ceramide liposome Than.Wherein, the assistant for emulsifying agent can be that this field is conventional, be preferably selected from sugar ester, sucrose fatty ester, alkyl glycosides, spit It is one or more in temperature 80 and polysorbas20.
Technical scheme of the present invention second is that:A kind of preparation method of above-mentioned ceramide liposome comprising following step Suddenly:
(1) glycerine, ethoxydiglycol, phosphatide and ceramide are taken, selectively add antioxidant, assistant for emulsifying agent and Moisturizer, Hybrid Heating is helped to obtain glycerite;
(2) the glycerite mixing obtained by step (1) is added in water intaking heating, and homogeneous is cooling, obtains first product;Selectively also Including:
(3) antiseptic is selectively added into the first product obtained by step (2), is uniformly mixed, you can.
Wherein, the temperature heated described in step (1) is preferably 80~100 DEG C, is more preferably 85 DEG C.
The temperature heated described in step (2) is preferably 80~100 DEG C, is more preferably 85 DEG C.
The speed of homogeneous described in step (2) is preferably 500~5000rpm, is more preferably 2500~4000rpm, into One step is more preferably 3500rpm.
The speed stirred when homogeneous described in step (2) is preferably 50~300rpm, is more preferably 150rpm.
The time of homogeneous described in step (2) is preferably 3~15min, is more preferably 10min;
The equipment of homogeneous described in step (2) can be common homogeneous blender;
Cooling temperature described in step (2) is preferably 40~60 DEG C, is more preferably 50 DEG C.
The three of technical scheme of the present invention are:A kind of application of above-mentioned ceramide liposome in cosmetics, wherein institute Ceramide liposome is stated preferably as cosmetic additive agent.
The ceramide liposome is when as cosmetic additive agent, ceramide therein and horn cell compatibility It is greatly improved, has effects that good moisturizing, antiallergic and repairs.
On the basis of common knowledge of the art, above-mentioned each optimum condition can be combined arbitrarily to get each preferable reality of the present invention Example.
The reagents and materials used in the present invention are commercially available.
The positive effect of the present invention is that:Ceramide liposome stability prepared by the present invention is high, disperses in water Property it is good, grain size reach 50~500nm of nanoscale;And production is convenient, using common homogeneous blender T25Digital Package 1 (IKA).
Description of the drawings
Fig. 1 is liposomal particle size distribution map.
Fig. 2 is variation tendency of the patient using skin TEWL values after liposome;The competing product are patent application Ceramide nanoemulsion in CN201310732992.2;The non-liposomal control refers to that ceramide is directly dissolved It is obtained in grease (caprylic/capric triglyceride).
Specific implementation mode
It is further illustrated the present invention below by the mode of embodiment, but does not therefore limit the present invention to the reality It applies among a range.In the following examples, the experimental methods for specific conditions are not specified, according to conventional methods and conditions, or according to quotient Product specification selects.
" granularmetric analysis test " is used to the granularmetric analysis of liposome obtained by embodiment, which passes through Malvern laser grain It spends analyzer and tests liposomal particle size size.
The model T25Digital Package 1 (IKA) of homogenizer used in following embodiments.
Embodiment 1
Glycerine 5g, lecithin 1g, ceramide 0.2g, tocopherol acetate 0.1g and ethoxydiglycol 3g are weighed, 85 DEG C are heated to, is stirred to transparent and homogeneous glycerite;In container, water 89.7g is added, is heated to 85 DEG C, opens homogeneous Machine rate 1000rpm, stir speed (S.S.) 50rpm are slowly added into glycerite, and homogeneous 3min stops homogeneous, and stirring is cooled to 50 DEG C, parahydroxyacet-ophenone 0.5g, hexylene glycol 0.5g is added, is stirred to being completely dissolved.Liposomal particle size is distributed: 82.3% grain size is 164.2 nanometers, and 17.7% is 22.08 nanometers (Fig. 1);Illustrate that liposome has sufficiently achieved nano particle Size, and particle diameter distribution is uniform.
Embodiment 2
Glycerine 10g, lecithin 5g, Cer NS g, tocopherol acetate 0.3g and ethoxydiglycol 10g are weighed, 85 DEG C are heated to, is stirred to transparent and homogeneous glycerite;In container, water 71.7g is added, is heated to 85 DEG C, opens homogeneous Machine rate 1500rpm, stir speed (S.S.) 80rpm are slowly added into glycerite, and homogeneous 4min stops homogeneous, and stirring is cooled to 50 DEG C, parahydroxyacet-ophenone 0.5g, hexylene glycol 0.5g is added, is stirred to being completely dissolved.Liposomal particle size is distributed: 85.6% grain size is 202 nanometers;14.4% is 85 nanometers.
Embodiment 3
Weigh glycerine 20g, lecithin 5g, hydrolecithin 1g, ceramide 0.5g, tocopherol acetate 0.3g, sweet dew Sugar alcohol 5g and ethoxydiglycol 10g, is heated to 85 DEG C, is stirred to transparent and homogeneous glycerite;In container, it is added Water 57.2g is heated to 80 DEG C, opens homogenizer rate 1500rpm, stir speed (S.S.) 80rpm and is slowly added into glycerite, homogeneous 5min stops homogeneous, and stirring is cooled to 50 DEG C, and parahydroxyacet-ophenone 0.5g, hexylene glycol 0.5g is added, and is stirred to completely molten Solution.Liposomal particle size is distributed:91% grain size is 187 nanometers;9% is 275 nanometers.
Embodiment 4
Glycerine 30g, lecithin 30g, hydrolecithin 1g, Cer EOS 0g and ethoxydiglycol 20g are weighed, is added Heat is stirred to 85 DEG C to transparent and homogeneous glycerite;In container, water 8g is added, is heated to 85 DEG C, opens homogenizer rate 1500rpm, stir speed (S.S.) 80rpm are slowly added into glycerite, and homogeneous 3min stops homogeneous, and stirring is cooled to 50 DEG C, is added Parahydroxyacet-ophenone 0.5g, hexylene glycol 0.5g are stirred to being completely dissolved.Liposomal particle size is distributed:87.2% grain Diameter is 243 nanometers;13.8% is 168 nanometers.
Embodiment 5
Glycerine 50g, lecithin 0.5g, Tween-80 1g, ceramide 0.1g and ethoxydiglycol 1g are weighed, is added Heat is stirred to 85 DEG C to transparent and homogeneous glycerite;In container, water 46.4g is added, is heated to 85 DEG C, opens homogenizer Rate 1500rpm, stir speed (S.S.) 80rpm are slowly added into glycerite, and homogeneous 5min stops homogeneous, and stirring is cooled to 60 DEG C, Parahydroxyacet-ophenone 0.5g, hexylene glycol 0.5g is added, is stirred to being completely dissolved.Liposomal particle size is distributed:86.3% Grain size be 287 nanometers;13.7% is 143 nanometers.
Embodiment 6
Weigh glycerine 30g, lecithin 10g, Cer NP g, ethoxydiglycol 10g, mannitol 3g and 1,3- fourth Glycol 5g is heated to 85 DEG C, is stirred to transparent and homogeneous glycerite;In container, water 38g is added, is heated to 85 DEG C, opens Homogenizer rate 1500rpm, stir speed (S.S.) 80rpm are slowly added into glycerite, and homogeneous 4min stops homogeneous, and stirring is cooled to 40 DEG C, parahydroxyacet-ophenone 0.5g, hexylene glycol 0.5g is added, is stirred to being completely dissolved.Liposomal particle size is distributed: 91% grain size is 128 nanometers;9% is 247 nanometers.
Effect example 1
The particle diameter distribution for the ceramide liposome that Examples 1 to 6 is prepared is uniform, is now prepared into using embodiment 3 To liposome carry out water in dispersibility and stability experiment.According to experimental result (table 1) as it can be seen that the ceramide fat detected The stability of plastid is high, good dispersion in water.
Dispersibility and stability test data in the water for the ceramide liposome that 1 embodiment 3 of table is prepared
Effect example 2
Clinical trial:
According to 5% and 10%, (percentage is weight to the ceramide liposome that embodiment 3 is prepared respectively Percentage) additive amount be distributed in aqua spraying, ask patient's (red swelling of the skin, itch pain) of slight hormone dependant history of venereal disease, it is early Evening is each primary using spraying;Wherein, TEWL (transepidermal waterloss) refers to percutaneous loss of moist, is evaluation One of index of skin barrier function.When barrier function damage, TEWL values increase;On the contrary, when TEWL values reduce, prompting screen Barrier is repaired.As can be known from Fig. 2:The aqua spraying for being added with 5% and 10% ceramide liposome respectively can be obviously Improve the skin of patient, it was demonstrated that the reparation of liposome of the invention effect of releiving meets expection.

Claims (10)

1. a kind of ceramide liposome, which is characterized in that it includes following component:Glycerine 5~50%, ethoxydiglycol 1 ~20%, ceramide 0.1~10% and phosphatidase 0 .5~30%, 100% is complemented to water;The wherein described phosphatide is lecithin Fat and/or hydrolecithin, the ceramide liposome do not include cholesterol;The percentage is to account for ceramide liposome Mass percent.
2. ceramide liposome as described in claim 1, which is characterized in that it includes following component:Glycerine 10~30%, Ethoxydiglycol 1~10%, ceramide 0.5~10% and phosphatidase 5~10%, 100% is complemented to water;The percentage Than to account for the mass percent of ceramide liposome.
3. ceramide liposome as claimed in claim 1 or 2, which is characterized in that it further includes antioxidant 0.1~1%; Preferably, the antioxidant is one kind in tocopherol (vitamin E), ascorbic acid (vitamin C) and its derivative Or it is a variety of;The derivative is selected from tocopherol acetate, ascorbic acid glucoside, ascorbyl palmitate and 3-O- ethyls One or more in ascorbic acid, the percentage is the mass percent for accounting for ceramide liposome.
4. ceramide liposome as claimed in claim 1 or 2, which is characterized in that it further includes antiseptic, the antiseptic Content be preferably 0.04~0.7%, more preferably 0.5%;Preferably, the antiseptic be selected from parahydroxyacet-ophenone, oneself It is one or more in glycol, hydroximic acid, pentanediol, Chlorphenesin and methyl hydroxybenzoate;More preferably, the ceramide liposome Including parahydroxyacet-ophenone 0.5% and hexylene glycol 0.5% or decoyl hydroximic acid 0.05%, the percentage is to account for ceramide The mass percent of liposome.
5. ceramide liposome as claimed in claim 1 or 2, which is characterized in that it further includes assistant for emulsifying agent, described to help breast The content of agent is preferably 0.5~2%;More preferably 1%;
Preferably, the assistant for emulsifying agent is one in sugar ester, sucrose fatty ester, alkyl glycosides, Tween 80 and polysorbas20 Kind is a variety of;More preferably, the ceramide liposome includes Tween 80 1%;The percentage is to account for ceramide liposome Mass percent.
6. ceramide liposome as claimed in claim 1 or 2, which is characterized in that the ceramide liposome further includes Help moisturizer, described to help the content of moisturizer be preferably 5~8%, and the percentage is the quality hundred for accounting for ceramide liposome Divide ratio.
7. ceramide liposome as claimed in claim 6, which is characterized in that the moisturizer that helps is selected from mannose Alcohol, sorbierite, 1, it is one or more in 3 butanediols, propylene glycol and dipropyl glycol.
8. a kind of preparation method of such as claim 1~7 any one of them ceramide liposome, which is characterized in that it is wrapped Include following steps:
(1) glycerine, ethoxydiglycol, phosphatide and ceramide are taken, antioxidant, assistant for emulsifying agent are selectively added and helps guarantor Humectant, Hybrid Heating obtain glycerite;
(2) the glycerite mixing obtained by step (1) is added in water intaking heating, and homogeneous is cooling, obtains first product;Selectively also wrap It includes:
(3) antiseptic is selectively added into the first product obtained by step (2), is uniformly mixed, you can.
9. preparation method as claimed in claim 8, which is characterized in that the temperature heated described in step (1) is 80~100 DEG C, preferably 85 DEG C;
The temperature heated described in step (2) is 80~100 DEG C, preferably 85 DEG C;
The speed of homogeneous described in step (2) is 1000~1500rpm;
The speed stirred when homogeneous described in step (2) is 50~100rpm, preferably 80rpm;
The time of homogeneous described in step (2) is 3~5min;
The equipment of homogeneous described in step (2) is common homogeneous blender;
And/or cooling temperature described in step (2) is 40~60 DEG C, preferably 50 DEG C.
10. such as application of the claim 1~7 any one of them ceramide liposome in cosmetics, wherein the nerve Amide lipid body is preferably as cosmetic additive agent.
CN201810215403.6A 2018-03-15 2018-03-15 Ceramide liposome and preparation method and application thereof Active CN108272652B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810215403.6A CN108272652B (en) 2018-03-15 2018-03-15 Ceramide liposome and preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810215403.6A CN108272652B (en) 2018-03-15 2018-03-15 Ceramide liposome and preparation method and application thereof

Publications (2)

Publication Number Publication Date
CN108272652A true CN108272652A (en) 2018-07-13
CN108272652B CN108272652B (en) 2020-12-22

Family

ID=62809756

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810215403.6A Active CN108272652B (en) 2018-03-15 2018-03-15 Ceramide liposome and preparation method and application thereof

Country Status (1)

Country Link
CN (1) CN108272652B (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110101591A (en) * 2019-05-23 2019-08-09 广州科斯曼生物科技有限公司 A kind of long-acting moisture-keeping composition and its preparation method and application
CN110339085A (en) * 2019-02-20 2019-10-18 广东芭薇生物科技股份有限公司 A kind of composition and its application containing ceramide liposome
CN110420127A (en) * 2019-08-22 2019-11-08 陕西慧康生物科技有限责任公司 A kind of essence and preparation method thereof with pearlescent appearance
CN110974750A (en) * 2019-12-30 2020-04-10 杭州暮色化妆品有限公司 Repairing and moisturizing composition and preparation method thereof
CN111743807A (en) * 2020-08-03 2020-10-09 上海奥利实业有限公司 Water-oil insoluble transparent ceramide aqueous solution and preparation method thereof
CN112891248A (en) * 2021-02-07 2021-06-04 上海奥利实业有限公司 Water-oil insoluble ceramide transparent oil solution and preparation method thereof
CN114028260A (en) * 2021-11-09 2022-02-11 上海药坦药物研究开发有限公司 Ceramide E emulsifier, preparation method thereof and application thereof in cosmetics
CN114028261A (en) * 2021-11-26 2022-02-11 浙江宜格企业管理集团有限公司 Flexible liposome with high ceramide load capacity and preparation method thereof
CN114224841A (en) * 2022-01-21 2022-03-25 上海彤颜实业有限公司 WGX-50 liposome, preparation method and application
CN115252502A (en) * 2022-08-26 2022-11-01 嘉文丽(福建)化妆品有限公司 Preparation method of hibiscus mutabilis extract liposome and liposome thereof
CN115381731A (en) * 2021-11-02 2022-11-25 广州雅纯化妆品制造有限公司 Plant-derived ceramide nano liposome composition and preparation method thereof
CN115737453A (en) * 2022-12-20 2023-03-07 广州旭帆生物科技有限公司 Nano-efficacy substance inclusion soluble in transparent aqueous solution and preparation method thereof
CN116139036A (en) * 2022-12-17 2023-05-23 上海优康化妆品有限公司 Vitamin C-containing coated particles, preparation method thereof and vitamin C-containing essence

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105616176A (en) * 2016-03-21 2016-06-01 东南大学 Phenylethyl resorcinol high-loading lipid nanocapsule and preparation method thereof
CN106214512A (en) * 2016-08-22 2016-12-14 欧诗漫生物股份有限公司 A kind of essence containing Cer NS & carnosine submicron liposome and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105616176A (en) * 2016-03-21 2016-06-01 东南大学 Phenylethyl resorcinol high-loading lipid nanocapsule and preparation method thereof
CN106214512A (en) * 2016-08-22 2016-12-14 欧诗漫生物股份有限公司 A kind of essence containing Cer NS & carnosine submicron liposome and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
G: "Perricone MD Hypoallergenic Nourishing Moisturizer", 《HTTP://WWW.COSDNA.COM/CHS/COSMETIC_D29470464.HTML》 *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110339085A (en) * 2019-02-20 2019-10-18 广东芭薇生物科技股份有限公司 A kind of composition and its application containing ceramide liposome
CN110101591B (en) * 2019-05-23 2022-01-18 广州科斯曼生物科技有限公司 Long-acting moisturizing composition and preparation method and application thereof
CN110101591A (en) * 2019-05-23 2019-08-09 广州科斯曼生物科技有限公司 A kind of long-acting moisture-keeping composition and its preparation method and application
CN110420127A (en) * 2019-08-22 2019-11-08 陕西慧康生物科技有限责任公司 A kind of essence and preparation method thereof with pearlescent appearance
CN110974750A (en) * 2019-12-30 2020-04-10 杭州暮色化妆品有限公司 Repairing and moisturizing composition and preparation method thereof
CN111743807A (en) * 2020-08-03 2020-10-09 上海奥利实业有限公司 Water-oil insoluble transparent ceramide aqueous solution and preparation method thereof
CN112891248A (en) * 2021-02-07 2021-06-04 上海奥利实业有限公司 Water-oil insoluble ceramide transparent oil solution and preparation method thereof
CN115381731A (en) * 2021-11-02 2022-11-25 广州雅纯化妆品制造有限公司 Plant-derived ceramide nano liposome composition and preparation method thereof
CN114028260A (en) * 2021-11-09 2022-02-11 上海药坦药物研究开发有限公司 Ceramide E emulsifier, preparation method thereof and application thereof in cosmetics
CN114028260B (en) * 2021-11-09 2023-12-08 上海药坦药物研究开发有限公司 Ceramide E emulsifier, preparation method thereof and application thereof in cosmetics
CN114028261A (en) * 2021-11-26 2022-02-11 浙江宜格企业管理集团有限公司 Flexible liposome with high ceramide load capacity and preparation method thereof
CN114224841A (en) * 2022-01-21 2022-03-25 上海彤颜实业有限公司 WGX-50 liposome, preparation method and application
CN115252502A (en) * 2022-08-26 2022-11-01 嘉文丽(福建)化妆品有限公司 Preparation method of hibiscus mutabilis extract liposome and liposome thereof
CN115252502B (en) * 2022-08-26 2023-08-22 嘉文丽(福建)化妆品有限公司 Preparation method of Hibiscus sabdariffa extract liposome and liposome thereof
CN116139036A (en) * 2022-12-17 2023-05-23 上海优康化妆品有限公司 Vitamin C-containing coated particles, preparation method thereof and vitamin C-containing essence
CN116139036B (en) * 2022-12-17 2024-02-27 上海优康化妆品有限公司 Vitamin C-containing coated particles, preparation method thereof and vitamin C-containing essence
CN115737453A (en) * 2022-12-20 2023-03-07 广州旭帆生物科技有限公司 Nano-efficacy substance inclusion soluble in transparent aqueous solution and preparation method thereof
CN115737453B (en) * 2022-12-20 2023-07-21 广州旭帆生物科技有限公司 Nanometer functional object inclusion soluble in transparent water agent and preparation method thereof

Also Published As

Publication number Publication date
CN108272652B (en) 2020-12-22

Similar Documents

Publication Publication Date Title
CN108272652A (en) A kind of ceramide liposome and its preparation method and application
TWI726954B (en) Oil-in-water emulsified composition and manufacturing method thereof
KR101123137B1 (en) manufacturing method of Composition of 2-layer
CN102327199B (en) Cosmetic composition comprising double-shell nano-structure
KR101867847B1 (en) O/W Emulsion having recrystallized particle and Cosmetic composition comprising thereof
CN108451787B (en) Vitamin A alcohol-embedded nano lipid carrier and preparation method thereof
CN113260422B (en) Ceramide dispersion composition
KR101780772B1 (en) Cosmetic composition stabilizing ceramides with multi-layer nano gel emulsion and manufacturing method thereof
CN104918600B (en) Emulsion compositions and application thereof
US20220339090A1 (en) Retinal-containing multilamellar vesicle and cosmetic composition comprising same
CN101827578B (en) Inverted vesicles
KR20130011800A (en) O/w emulsion having skin lipid and cosmetic composition comprising the same
KR20150077214A (en) Liquid crystal cosmetic composition having similar skin lipid composition and containing glucosylceramide, and preparation method thereof
KR20140073902A (en) Oil-drop type cosmetic composition
JP4049216B2 (en) Formulation with liquid crystal structure
WO2008107193A1 (en) Topical composition comprising retinoid receptor agonist for treatment of acne
KR20180106106A (en) Oil-in-water emulsion cosmetic composition improving deviation of emulsion particle size, and preparing method for the same
KR102500905B1 (en) Translucent nanoemulsion containing natural ceramide and cosmetic composition including the same
CN104379122B (en) Cosmetics and emulsification composition containing Enoxolone derivative
CN110141535B (en) Liquid crystal cream containing ceramide and preparation method thereof
JP6242422B2 (en) Cosmetic raw material manufacturing method
JP2008231087A (en) Skin preparation for external use
CN110251416A (en) A kind of Ceramide Complex and preparation method thereof
JP3557877B2 (en) Cosmetics obtained by dispersing a lipid dispersion composition in an aqueous medium
JP5602084B2 (en) Moisturizer and cosmetic containing the same

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20220207

Address after: 201404 workshop 1, building 4, No. 666, Jinbi Road, Jinhui Town, Fengxian District, Shanghai

Patentee after: Shanghai Zhina Biotechnology Co.,Ltd.

Address before: 8th Floor, Building No. 1, 333 Guiping Road, Xuhui District, Shanghai, 2003

Patentee before: LB COSMECEUTICAL TECHNOLOGY Co.,Ltd.