CN108261448A - Prevent transmissible gastroenteritis of swine Chinese medicine composition and preparation method thereof - Google Patents
Prevent transmissible gastroenteritis of swine Chinese medicine composition and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
The present invention relates to a kind of Chinese medicine compositions for preventing transmissible gastroenteritis of swine, and the component and its ratio of weight and number of Chinese medicine composition are respectively:20 60 parts of allicin powder;10 40 parts of spina date seed;10 40 parts of the Chinese bulbul;5 30 parts of the coptis;5 30 parts of Primula malacoides;5 30 parts of perfume Soviet Union grass;5 20 parts of corydalis tuber;Fry 5 20 parts of sophora flower, 10 30 parts of Radix Glycyrrhizae.Natural traditional Chinese medicine active ingredient there are many containing in the present invention, with bactericidal antiphlogistic, heat-clearing and damp-drying drug, the effect of purging intense heat and detonicating, to illnesss excellents such as toxic-heat and blood stasis caused by treatment transmissible gastroenteritis of swine, damp and hot feeling of fullness, vomiting acid regurgitation, dysphoria and insomnia, indigestion, rush down dysenteries, and it has no toxic side effect, medicament residue will not be generated, and has the effect of tranquilizing the mind resisting stress.
Description
Technical field
The invention belongs to field of veterinary, especially a kind of Chinese medicine composition for preventing transmissible gastroenteritis of swine and its preparation side
Method.
Background technology
Transmissible gastroenteritis of swine disease is to vomit, severe diarrhea is main feature, to the high lethality of piglet within 2 week old
(be usually 100%) causes serious financial consequences to aquaculture, in the present invention for the various illnesss of transmissible gastroenteritis of swine into
It has gone research experiment, has obtained the effect of relatively satisfactory.
Invention content
The purpose of the present invention is to provide a kind of Chinese medicine composition for preventing transmissible gastroenteritis of swine, Chinese medicine composition tools
There is the effect of bactericidal antiphlogistic, heat-clearing and damp-drying drug, purging intense heat and detonicating, dysentery abdominal pain, stomach caused by can effectively treating transmissible gastroenteritis of swine
Intestines such as stagnate at the diseases such as diseases, and have the effect of tranquilizing the mind resisting stress.
It is another object of the present invention to provide a kind of preparation sides for the Chinese medicine composition for preventing transmissible gastroenteritis of swine
Method.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine composition for preventing transmissible gastroenteritis of swine, Chinese medicine composition component and its ratio of weight and number difference
For:
20-60 parts of allicin powder;
10-40 parts of spina date seed;
10-40 parts of the Chinese bulbul;
5-30 parts of the coptis;
5-30 parts of Primula malacoides;
5-30 parts of grass of perfume Soviet Union;
5-20 parts of corydalis tuber;
5-20 parts of sophora flower is fried,
10-30 parts of Radix Glycyrrhizae.
A kind of preparation method for the Chinese medicine composition for preventing transmissible gastroenteritis of swine, its step are as follows:
(1) it weighs the report Chinese bulbul respectively by weight ratio, the coptis, Primula malacoides, fragrant Soviet Union's grass, corydalis tuber, fry sophora flower, Radix Glycyrrhizae difference
8 times of amounts, 6 times of amount water is added to decoct twice, 1 hour every time, decocting liquid obtained A decocting liquids after merging, spare;
(2) spina date seed is weighed according to weight proportion, is mixed after crushing with allicin powder, and added water to cook 3 times, first time 2
Hour, second and each 1 hour of third time, merge decoction liquor, filtration, filtrate is concentrated into relative density as 1.20~1.25 simultaneously
2mol/L hydrochloric acid solutions are added at 80 DEG C and adjust pH value to 1.0~2.0,1 hour is kept the temperature, stands 10 hours, filtration is sunk
It forms sediment, into precipitation plus 6~8 times are measured water, form mixed liquor, with 40% sodium hydroxide solution tune pH value to 7.0, then plus and mixed liquor
A concentration of 95% isometric ethanol solution, is stirred to dissolve, and filters, filtrate 2mol/L hydrochloric acid solution tune pH value to 2.0,
20~30 minutes are kept the temperature at 60 DEG C, stands 12 hours, filtration, precipitation is washed till pH value to 7.0 with ethyl alcohol, after waving most ethyl alcohol, with
Gained A decocting liquids merge in step (1), are concentrated into density and reach 1.20g/ml and obtain B decocting liquids, spare;
(3) by the spray-dried device of B decocting liquids obtained by step (2), under the conditions of 120 DEG C, fine powder is spray dried to get anti-
Control the Chinese medicine composition finished product of transmissible gastroenteritis of swine.
Advantages of the present invention and advantageous effect are:
1st, the spina date seed in the present invention, the Chinese bulbul, the coptis, Primula malacoides, fragrant Soviet Union's grass, corydalis tuber, stir-fry sophora flower, Radix Glycyrrhizae are as natural
Chinese medicinal ingredients have the effect of good bactericidal antiphlogistic, heat-clearing and damp-drying drug, purging intense heat and detonicating, to toxic-heat and blood stasis, damp and hot feeling of fullness, vomiting
The symptoms such as acid regurgitation, dysphoria and insomnia, indigestion have good curative effect.
2nd, the spina date seed ingredient in the present invention has effects that antibacterial anti-inflammatory, calms the nerves and ease pain, is digestant, to pig stomach intestinal inflammation
There is a good curative effect, it is aid digestion while can also substantially reduce injury of the livestock and poultry stress reaction to itself.
3rd, the present invention is quickly sprayed extracting solution using spray drying device by after the extracted process of Chinese medicine composition
Powder changes previous conventional drying processes, greatly reduces production time and production cost, protects in Chinese medical extract
Active ingredient will not go bad at high temperature.The high-speed rotating nozzle of the spray-dried device of Chinese medicine extract need not crush after spraying,
Micropowders are dried to rapidly, pig body of having wholesome effects absorbs, and can greatly reduce dosage and time of administration, reduces aquaculture cost.
Specific embodiment
The present invention is described in further detail by following embodiment.It should be noted that:Following embodiments are illustrative, are not
It is limited, it is impossible to limit protection scope of the present invention with following embodiments.
Allicin powder, spina date seed, the Chinese bulbul, the coptis, Primula malacoides, fragrant Soviet Union's grass in the present invention, corydalis tuber, stir-fry sophora flower, Radix Glycyrrhizae
It can be commercially available on the market.
Embodiment 1
A kind of Chinese medicine composition for preventing transmissible gastroenteritis of swine, its composition component and its weight are respectively:Allicin
Powder 20kg, it spina date seed 10kg, Chinese bulbul 10kg, coptis 5kg, Primula malacoides 5kg, fragrant Soviet Union grass 5kg, corydalis tuber 5kg, fries sophora flower 5kg, is sweet
Careless 10kg.
A kind of preparation method for the Chinese medicine composition for preventing transmissible gastroenteritis of swine, its step are as follows:
(1) Primula malacoides, folium isatidis, roundleaf dutchmanspipe root, green peel, trigone, the coptis, Cortex Phellodendri, allicin are weighed respectively by weight ratio
Powder, the compound of glauber-salt and liquorice add 8 times of amounts, 6 times of amount water to decoct twice respectively, and 1 hour every time, decocting liquid obtained A decocting liquids after merging, spare;
(2) spina date seed is weighed according to weight proportion, is added water to cook after crushing 3 times, 2 hours for the first time, second and the
Each 1 hour three times, merge decoction liquor, filtration, filtrate is concentrated into relative density and is 1.20~1.25 and adds in 2mol/ at 80 DEG C
L hydrochloric acid solutions adjust pH value to 1.0~2.0, keep the temperature 1 hour, stand 11~13 hours, filtration is precipitated, and is added into precipitation
6~8 times of amount water, form mixed liquor, with 40% sodium hydroxide solution tune pH value to 7.0, then add and the isometric concentration of mixed liquor
For 90~95% ethanol solution, be stirred to dissolve, filter, filtrate with 2mol/L hydrochloric acid solution tune pH value to 2.0,55~65
25~35 minutes are kept the temperature at DEG C, stands 10~14 hours, filtration, precipitation is washed till pH value to 7.0 with ethyl alcohol, after waving most ethyl alcohol, with
Gained A decocting liquids merge in step (1), are concentrated into density and reach 1.20g/ml and obtain B decocting liquids, spare;
(3) by the spray-dried device of B decocting liquids obtained by step (2), under the conditions of 120 DEG C, 250 turns, fine powder is spray dried to,
Up to the Chinese medicine composition finished product of prevention transmissible gastroenteritis of swine.
Embodiment 2
A kind of preparation method for the Chinese medicine composition for preventing transmissible gastroenteritis of swine, its composition component and its weight difference
For:Allicin powder 60g, spina date seed 40g, Chinese bulbul 40g, coptis 30g, Primula malacoides 30g, fragrant Soviet Union grass 30g, corydalis tuber 20g, sophora flower is fried
20g, Radix Glycyrrhizae 30g.
The step of preparation method, is the same as embodiment 1.
Embodiment 3
Prevent transmissible gastroenteritis of swine Chinese medicine composition Chinese medicine composition preparation method, its composition component and its
Weight is respectively:Allicin powder 4kg, spina date seed 3kg, Chinese bulbul 3kg, coptis 2.5kg, Primula malacoides 2.5kg, fragrant Soviet Union grass 2.5kg,
Corydalis tuber 1.5kg, sophora flower 1.5kg, Radix Glycyrrhizae 2kg are fried.
The step of preparation method, is the same as embodiment 1.
The present invention can be direct plungeed into pig's feed and be fed, and dosage is bred pigs 150g-200g;Piglet 60-90g.
Clinical practice is tested
1st, experimental method
At the beginning of 2015, gastroenteritis sick pig is made a definite diagnosis to Tianjin Wuqing cultivation base by my company, provides free treatment of the present invention
And track statistics treatment results.
2nd, experimental result
Morbidity rehabilitation situation is recorded by primary part observation to obtain as a result, experimental group curative effect using the present invention is apparent,
In medication is 3 days average, ill domestic animal feeding increases, and drains improving situation, and medication searches for food in 5 days, restores normal, sick pig in therapeutic process
Without apparent stress reaction.Experimental group of the present invention is longer than using the drug effect time after the experimental group dispensing of other drugs treatment, is controlled
Ill domestic animal extends with apparent stress reaction, recovery time during treatment.
Claims (2)
1. a kind of Chinese medicine composition for preventing transmissible gastroenteritis of swine, it is characterised in that:The Chinese medicine composition component and its weight
Portion rate is respectively:
20-60 parts of allicin powder;
10-40 parts of spina date seed;
10-40 parts of the Chinese bulbul;
5-30 parts of the coptis;
5-30 parts of Primula malacoides;
5-30 parts of grass of perfume Soviet Union;
5-20 parts of corydalis tuber;
5-20 parts of sophora flower is fried,
10-30 parts of Radix Glycyrrhizae.
2. a kind of preparation method of the Chinese medicine composition of prevention transmissible gastroenteritis of swine as described in claim 1, feature exist
In:The step of preparation method, is as follows:
(1) the report Chinese bulbul, the coptis, Primula malacoides, fragrant Soviet Union's grass, corydalis tuber, stir-fry sophora flower, Radix Glycyrrhizae are weighed respectively by weight ratio and adds 8 respectively
Amount, 6 times of amount water decoct twice again, and 1 hour every time, decocting liquid obtained A decocting liquids after merging, spare;
(2) spina date seed is weighed according to weight proportion, is mixed after crushing with allicin powder, and added water to cook 3 times, 2 hours for the first time,
Second and for the third time each 1 hour, merge decoction liquor, filtration, it is 1.20~1.25 and 80 that filtrate, which is concentrated into relative density,
DEG C when add in 2mol/L hydrochloric acid solutions and adjust pH value to 1.0~2.0, keep the temperature 1 hour, stand 10 hours, filtration is precipitated,
Into precipitation plus 6~8 times of amount water, mixed liquor is formed, with 40% sodium hydroxide solution tune pH value to 7.0, then add with mixed liquor etc.
A concentration of 95% ethanol solution of volume, is stirred to dissolve, filtration, filtrate 2mol/L hydrochloric acid solution tune pH value to 2.0,
20~30 minutes are kept the temperature at 60 DEG C, stands 12 hours, filtration, precipitation is washed till pH value to 7.0 with ethyl alcohol, after waving most ethyl alcohol, with step
Suddenly gained A decocting liquids merge in (1), are concentrated into density and reach 1.20g/ml and obtain B decocting liquids, spare;
(3) by the spray-dried device of B decocting liquids obtained by step (2), under the conditions of 120 DEG C, fine powder is spray dried to get prevention pig
The Chinese medicine composition finished product of transmissible gastroenteritis.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109316505A (en) * | 2018-11-28 | 2019-02-12 | 周广生 | A kind of pharmaceutical composition and preparation method thereof for treating piglet transmissible gastroenteritis |
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CN102343000A (en) * | 2010-07-30 | 2012-02-08 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition with blood cooling and diarrhea stopping functions for livestock and poultries |
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2016
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CN102343000A (en) * | 2010-07-30 | 2012-02-08 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition with blood cooling and diarrhea stopping functions for livestock and poultries |
CN103656021A (en) * | 2012-09-24 | 2014-03-26 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composition for livestock with effects of relieving stagnant qi and dissipating swelling, and relaxing bowel, as well as preparation method of traditional Chinese medicinal composition |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109316505A (en) * | 2018-11-28 | 2019-02-12 | 周广生 | A kind of pharmaceutical composition and preparation method thereof for treating piglet transmissible gastroenteritis |
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Application publication date: 20180710 |