CN102258711B - Medicinal composition for treating common cold and preparation method thereof - Google Patents
Medicinal composition for treating common cold and preparation method thereof Download PDFInfo
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Abstract
The invention provides a medicinal composition for treating common cold. The medicinal composition comprises the following raw material medicine components in parts by weight: 3-15 parts of honeysuckle, 3-15 parts of fructus forsythiae, 3-15 parts of heartleaf houttuynia herb, 7-25 parts of reed rhizome, 3-15 parts of boat-fruited sterculia seed, 3-15 parts of bulbus fritillariae cirrhosae, 3-15 parts of Chinese olive, 3-15 parts of dwarf lilyturf root and 1-10 parts of almond. The medicament has the effects of dispelling wind and relieving exterior syndrome, clearing heat and relieving exterior syndrome, nourishing yin and moistening lung, relieving cough and reducing sputum. The preparation has the advantages of stable quality, definite therapeutic effect and low toxic or side effect and can be used for safely and effectively treating wind heat type common cold and concurrent acute tonsillitis, acute pharyngitis, acute laryngitis, acute tracheitis and acute pneumonia of the wind heat type common cold.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of compositions of treating coldrex and preparation method thereof.
Background technology
" flu " speech is shown in China's " Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House in the Northern Song Dynasty the earliest.All wind ", put down in writing shensu drink in its cold side's opinion and controlled: " it is low voice speaking to cough for flu ailment said due to cold or exposure, fever and headache, and tears saliva is sticky ".Assertive evidence is different with typhoid fever, " Jing Yue's complete work.Cold " piece of writing says: " disease of cold, this is by diseases caused by exogenous pathogenic factor, but evil the lighter only violates fur even dark person is typhoid fever all over the network of transmitting scriptures, and heresy is shallow, is cold." the primary disease pathogeny is that exopathogen is invaded due to lung defends, so generally all there is lung to defend exterior syndrome, thereby from the beginning of method of treatment, be main with inducing diaphoresis to expel pathogens.Like empty people's flu, sense is sent out repeatly repeatly, and healthy energy is more empty, and pathogen is reluctant to leave, and ought set upright again with evil and take into account.Flu typing: the difference of anemofrigid cold (is main symptom with the coldness of the body general pain), anemopyretic cold (with not cold but the pharyngalgia heating is a main symptom), exogenous cold interior-heat (symptom of being afraid of cold, but interior-heat symptom such as bitter taste in the mouth and dry throat constipation is arranged), rheumatism flu (common cold of gastrointestinal type), pathogenic dryness flu (is master's flu with dry body fluid with thanksing to less), empty people flu (deficiency of vital energy flu, yang deficiency flu, the deficiency of YIN are caught a cold, blood deficiency is caught a cold).And the last word of Chinese medicine is the ternary theory of medicine of Wu Xuewen invention recently, and ternary thought will replace the dialectical superclass status of negative and positive, thinks that flu belongs to a kind of of " poison ", is pathogenic wind toxic.Pathogenic wind toxic divides the difference of wind and cold, wind heat, rheumatism again.Ternary medical science thinks, the fire-toxin that belong to of getting angry more, and heating fever, but when not feeling cold, be called pyretic toxicity has fire to resemble to accompany hemorrhage, is called the blood poison.And negative and positive of qi and blood is weak not enough, is the reason of empty people's flu, and characteristics are respectively arranged: deficiency of vital energy flu is seen outbreak repeatedly more, and asthenia is unable, and yang deficiency many coldness of the body of catching a cold are heavier, and deficiency of YIN flu belongs to pathogenic dryness hurts sb.'s feelings, and the inherent body constitution of blood deficiency flu and anemia has very big relation.Flu can cause the disease of each internal organs, causes cardiac muscle and valvular heart disease like flu, and flu causes that lung system is sick, and flu causes liver-gallbladder disease, and flu causes nephropathy, and flu causes gastrointestinal disease etc., and flu causes encephalopathy etc.
For flu, also there is not the specific treatment medicine so far.Medicines such as Moroxydine, vidarabine, polyinosini have certain inhibitory action to some virus breeding, but can not cause that the virus of common cold is all effective to all.
At present commercially available Coritab is numerous in variety, is mostly compound preparation, and compound preparation mainly is to utilize between the various medicines to have synergism, brings into play the advantage of each medicine, reaches the purpose of symptomatic treatment.Though aspect the symptoms such as the headache that chemicals causes because of flu in alleviation, heating, cough, nasal obstruction, watery nasal discharge, sneeze curative effect is preferably arranged; But it mainly is a relief of symptoms, and majority of compounds process cold medicine brought that side effect such as drowsiness also can not be ignored.The Chinese medicine of treatment flu at present is a lot, and dosage form is also varied, existing onset slowly pill, also onset drop pill, injection, injectable powder rapidly arranged; Existingly replace the granule of tea-drinking, also the tablet of taking convenience arranged; Effervescent in the existing patient's of satisfying curiosity, also have suitable
Children's's suppository, but from present clinical practice curative effect, no matter be single preparations of ephedrine or compound preparation, curative effect of medication is low still to be one of principal element that influences patient's use.High in the natural degree of Chinese medicine, side effect is low; In the selection that the combination drug curative effect is high and pair is big, the patient often abandons the low Chinese medicine of toxic and side effects and selects the bigger combination drug of side effect to treat flu, in the hope of quick relief of symptoms.The traditional Chinese medical science thinks that cure the disease must strengthening vital QI to eliminate pathogenic factors, treating both the principal and secondary aspects of a disease, is exactly through the enhancing body resistance, to reach restorative purpose.The western medicine flu mainly is the cause of disease therapy, promptly attempts eliminating bacteria virus, but because the effect of Western medicine anti-viral is unsatisfactory, so Western medicine can only be an anti symptom treatment at present, controls its cardinal symptom, " curing the symptoms, not the disease " of just saying usually.Existing Western medicine antiviral strength is not strong, causes the abuse to antibiotics thus.And antibiotics does not have antiviral effect, and abuse has only side effect.
Like Chinese invention patent publication number CN101396528B, denomination of invention is: " a kind of compound Chinese medicinal preparation of treating anemopyretic cold " discloses a kind of pharmaceutical preparation of treating anemopyretic cold.It is to be prepared from Flos Lonicerae 100-200g, Fructus Forsythiae 100-200g, Fructus Arctii 50-120g, Rhizoma Phragmitis 20-100g, Radix Scutellariae 20-90g, Radix Platycodonis 20-90g, Semen Sojae Preparatum 20-90g, Rhizoma Et Radix Notopterygii 20-90g, Cornu Saigae Tataricae powder 1-15g, GANGCAO GAO 10-20g, Mentholum 0.1-1g, Herba Schizonepetae spike oil 0.1-1ml.But adopted the component of Radix Platycodonis and GANGCAO GAO in the pharmaceutical composition of this kind treatment flu, its pharmacological action is unfavorable for complementing each other to reach the effect of heat clearing away with components such as Flos Lonicerae, Fructus Forsythiae, Rhizoma Phragmitiss; And, include the drug component that is exclusively used in the treatment anemofrigid cold in the pharmaceutical composition of this treatment flu: Rhizoma Et Radix Notopterygii, the adding of component Rhizoma Et Radix Notopterygii is unfavorable treats the anemopyretic cold symptom with other component combineds effect; Simultaneously, the Cornu Saigae Tataricae powder in the pharmaceutical composition of this treatment flu generally rises to more than 38.5 degrees centigrade at patient temperature and adopts just now, otherwise can produce bigger toxic and side effects; In addition, the pharmaceutical composition of this treatment flu does not have the effect of cough-relieving, can't treat the concurrent acute tonsillitis of anemopyretic cold, acute pharyngitis, acute laryngitis, acute tracheitis, acute pneumonia.
Summary of the invention
In order to address the above problem, the present invention provides that a kind of quality of the pharmaceutical preparations is stable, determined curative effect, toxic and side effects are low, treat anemopyretic cold safely and effectively and by the pharmaceutical composition of the concurrent acute tonsillitis of anemopyretic cold, acute pharyngitis, acute laryngitis, acute tracheitis, acute pneumonia.It has the effect of dispelling wind to relieve the exterior syndrome, clearing away heat and expelling pathogen in the exterior, nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing.
In addition, the present invention also provides this kind preparation of drug combination method.
For reaching above purpose technical scheme of the present invention:
A kind of pharmaceutical composition of treating flu, pharmaceutical composition of the present invention is to comprise: Flos Lonicerae, Fructus Forsythiae, Herba Houttuyniae, Rhizoma Phragmitis, Semen Sterculiae Lychnophorae, Bulbus Fritillariae Cirrhosae, Fructus Canarii, Radix Ophiopogonis, Semen Armeniacae Amarum;
The consumption of each component of medicine of the present invention and proportioning obtain with Test Summary through groping in a large number through the inventor, and each component raw material medicine all has curative effect preferably at the following weight parts ratio range:
Flos Lonicerae 3-15 part, Fructus Forsythiae 3-15 part, Herba Houttuyniae 3-15 part, Rhizoma Phragmitis 7-25 part, Semen Sterculiae Lychnophorae 3-15 part, Bulbus Fritillariae Cirrhosae 3-15 part, Fructus Canarii 3-15 part, Radix Ophiopogonis 3-15 part, Semen Armeniacae Amarum 1-10 part.
Further, preferred each component raw material medicine of pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: 5 parts of Flos Loniceraes, 5 parts of Fructus Forsythiaes, 5 parts of Herba Houttuyniae, 9 parts of Rhizoma Phragmitiss, 5 parts of Semen Sterculiae Lychnophoraes, 9 parts of Bulbus Fritillariae Cirrhosaes, 9 parts of Fructus Canariis, 5 parts of Radix Ophiopogonis, 5 parts in Semen Armeniacae Amarum.
One go on foot ground again, a kind of in addition each component raw material medicine of preferred pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Herba Houttuyniae, 25 parts of Rhizoma Phragmitiss, 15 parts of Semen Sterculiae Lychnophoraes, 15 parts of Bulbus Fritillariae Cirrhosaes, 15 parts of Fructus Canariis, 15 parts of Radix Ophiopogonis, 10 parts in Semen Armeniacae Amarum.
As a kind of preferred, the said Semen Armeniacae Amarum in the pharmaceutical composition of the present invention is a blanched almonds.
Medicine of the present invention can be processed any preparation on the pharmaceutics; Preferably process tablet, sugar coated tablet, film coated tablet, enteric coated tablet, suck agent, oral liquid, granule, soft capsule, capsule, electuary, pill, powder, drop pill; The best is processed oral liquid, tablet, capsule, granule, drop pill, soft capsule.
The preparation of the effective ingredient of the described present composition and preparation can adopt following method: one or several Combined application preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.For example, can these crude drug pulverize mix homogeneously be processed powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is processed oral liquid then; But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract to raw material, process pill, oral liquid, tablet, granule, capsule, soft capsule, but this can not limit protection scope of the present invention.
The weight portion proportioning that following effective ingredient extracts raw materials used medicine can be any proportioning, and preferred feedstock medicine weight portion proportioning is a dosage range provided by the present invention.
The method for preparing of the oral liquid of Chinese medicine composition of the present invention comprises the steps:
A. extracting honeysuckle 3-15 part, Fructus Forsythiae 3-15 part, Herba Houttuyniae 3-15 part, Rhizoma Phragmitis 7-25 part, Semen Sterculiae Lychnophorae 3-15 part, Bulbus Fritillariae Cirrhosae 3-15 part, Fructus Canarii 3-15 part, Radix Ophiopogonis, 3-15 part, Semen Armeniacae Amarum 1-10 part were subsequent use;
B. the extraction of extractum I: Flos Lonicerae adds water temperature and soaks secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merges infusion for the second time; Fructus Forsythiae, Rhizoma Phragmitis decocting in water secondary boiled 2 hours with 10-15 times of water gaging for the first time, doubly measured with 6-12 for the second time, and decocting in water 2 hours merges water cooking liquid; Semen Sterculiae Lychnophorae decocting in water secondary boiled 2 hours with 6-12 times of water gaging for the first time, boiled 2 hours with 3-8 times of water gaging for the second time; Merge above-mentioned warm macerating liquid and water cooking liquid, and Bulbus Fritillariae Cirrhosae is added water temperature soak secondary; For the first time with 10-15 times of water gaging warm macerating 1.5 hours; In being filtered in 1 hour with 6-10 times of water gaging warm macerating for the second time, merging is condensed into cream (surveying relative density 1.2-1.3 for 50 ℃), gets extractum I;
The extraction of extractum II: 1. extract volatile oil: get Herba Houttuyniae, Fructus Canarii, Radix Ophiopogonis, Semen Armeniacae Amarum four Chinese medicine material, merge together, add 1～12 times of water gaging, soak after 0.5～5 hour, adopted steam distillation 1～8 hour, collect volatile oil device preservation in addition, medicinal residues continue to extract; 2. extract: the medicinal residues decocte with water behind extraction such as all the other medical materials and Fructus Canarii, Semen Armeniacae Amarum medicinal residues and the Flos Lonicerae volatile oil 1～3 time, decocted 0.5～3 hour at every turn, collecting decoction filters, and filtrating is concentrated into relative density 1.00～1.35 in the time of 50～80 ℃, puts cold; 3. precipitate with ethanol: add ethanol and make and contain the alcohol amount and reach 10～85%, left standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 ℃, get extractum II;
C. dosing: take by weighing extractum I, add water, stir down it was boiled 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 ℃ and kept 2～30 minutes, filter; In an amount of polysorbate, add volatile oil, be stirred to mix homogeneously, get fragrant solution; With above-mentioned three kinds of combining medicine, add water, stir, heated and boiled 5～50 minutes, put cold, to below 80 ℃, then with medical filtration;
D. fill, gland, 90～150 ℃ of sterilizations of logical then steam 5～60 minutes promptly get oral liquid.
More than form when producing and to increase or to reduce according to corresponding ratio; Like large-scale production can be unit with kilogram or with the ton; Small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
Advantage of the present invention and beneficial effect:
Medicine of the present invention has the effect of dispelling wind to relieve the exterior syndrome, clearing away heat and expelling pathogen in the exterior, nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing.Its quality of the pharmaceutical preparations is stable, determined curative effect, toxic and side effects are low, can treat anemopyretic cold safely and effectively and by the concurrent acute tonsillitis of anemopyretic cold, acute pharyngitis, acute laryngitis, acute tracheitis, acute pneumonia.The present invention had both treated primary symptom, treated hold concurrently disease or complication again, strengthening vital QI to eliminate pathogenic factors, and treating both the principal and secondary aspects of a disease is used for treatment, and curative effect is faster and better, often can get instant result.Can be used for the emergency treatment first aid, also can be used for general out patient service or clinic, pharmacy or home-use subsequent use medicine.Being widely used, really is good side's good medicine.
The specific embodiment
A kind of pharmaceutical composition of treating flu, pharmaceutical composition of the present invention is to comprise: Flos Lonicerae, Fructus Forsythiae, Herba Houttuyniae, Rhizoma Phragmitis, Semen Sterculiae Lychnophorae, Bulbus Fritillariae Cirrhosae, Fructus Canarii, Radix Ophiopogonis, Semen Armeniacae Amarum;
The consumption of each component of medicine of the present invention and proportioning obtain with Test Summary through groping in a large number through the inventor, and each component raw material medicine all has curative effect preferably at the following weight parts ratio range:
Flos Lonicerae 3-15 part, Fructus Forsythiae 3-15 part, Herba Houttuyniae 3-15 part, Rhizoma Phragmitis 7-25 part, Semen Sterculiae Lychnophorae 3-15 part, Bulbus Fritillariae Cirrhosae 3-15 part, Fructus Canarii 3-15 part, Radix Ophiopogonis 3-15 part, Semen Armeniacae Amarum 1-10 part.
Medicine of the present invention can be processed any preparation on the pharmaceutics; Preferably process tablet, sugar coated tablet, film coated tablet, enteric coated tablet, suck agent, oral liquid, granule, soft capsule, capsule, electuary, pill, powder, drop pill; The best is processed oral liquid, tablet, capsule, granule, drop pill, soft capsule.
The preparation of the effective ingredient of the described present composition and preparation can adopt following method: one or several Combined application preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.For example, can these crude drug pulverize mix homogeneously be processed powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is processed oral liquid then; But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract to raw material, process pill, oral liquid, tablet, granule, capsule, soft capsule, but this can not limit protection scope of the present invention.
The weight portion proportioning that following effective ingredient extracts raw materials used medicine can be any proportioning, and preferred feedstock medicine weight portion proportioning is a dosage range provided by the present invention.
The method for preparing of the oral liquid of Chinese medicine composition of the present invention comprises the steps:
A. extracting honeysuckle 3-15 part, Fructus Forsythiae 3-15 part, Herba Houttuyniae 3-15 part, Rhizoma Phragmitis 7-25 part, Semen Sterculiae Lychnophorae 3-15 part, Bulbus Fritillariae Cirrhosae 3-15 part, Fructus Canarii 3-15 part, Radix Ophiopogonis, 3-15 part, Semen Armeniacae Amarum 1-10 part were subsequent use;
B. the extraction of extractum I: Flos Lonicerae adds water temperature and soaks secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merges infusion for the second time; Fructus Forsythiae, Rhizoma Phragmitis decocting in water secondary boiled 2 hours with 10-15 times of water gaging for the first time, doubly measured with 6-12 for the second time, and decocting in water 2 hours merges water cooking liquid; Semen Sterculiae Lychnophorae decocting in water secondary boiled 2 hours with 6-12 times of water gaging for the first time, boiled 2 hours with 3-8 times of water gaging for the second time; Merge above-mentioned warm macerating liquid and water cooking liquid, and Bulbus Fritillariae Cirrhosae is added water temperature soak secondary; For the first time with 10-15 times of water gaging warm macerating 1.5 hours; In being filtered in 1 hour with 6-10 times of water gaging warm macerating for the second time, merging is condensed into cream (surveying relative density 1.2-1.3 for 50 ℃), gets extractum I;
The extraction of extractum II: 1. extract volatile oil: get Herba Houttuyniae, Fructus Canarii, Radix Ophiopogonis, Semen Armeniacae Amarum four Chinese medicine material, merge together, add 1～12 times of water gaging, soak after 0.5～5 hour, adopted steam distillation 1～8 hour, collect volatile oil device preservation in addition, medicinal residues continue to extract; 2. extract: the medicinal residues decocte with water behind extraction such as all the other medical materials and Fructus Canarii, Semen Armeniacae Amarum medicinal residues and the Flos Lonicerae volatile oil 1～3 time, decocted 0.5～3 hour at every turn, collecting decoction filters, and filtrating is concentrated into relative density 1.00～1.35 in the time of 50～80 ℃, puts cold; 3. precipitate with ethanol: add ethanol and make and contain the alcohol amount and reach 10～85%, left standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 ℃, get extractum II;
C. dosing: take by weighing extractum I, add water, stir down it was boiled 2～60 minutes, make abundant dissolving, filter; To extractum
Add water and other adjuvant among the II, stir, be heated to 30～80 ℃ and kept 2～30 minutes, filter; In an amount of polysorbate, add volatile oil, be stirred to mix homogeneously, get fragrant solution; With above-mentioned three kinds of combining medicine, add water, stir, heated and boiled 5～50 minutes, put cold, to below 80 ℃, then with medical filtration;
D. fill, gland, 90～150 ℃ of sterilizations of logical then steam 5～60 minutes promptly get oral liquid.
More than form when producing and to increase or to reduce according to corresponding ratio; Like large-scale production can be unit with kilogram or with the ton; Small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
Certainly; The pharmaceutical composition of treatment flu of the present invention also can adopt traditional method: place the medicine of above composition in the clean marmite, add clean drinking water, 3-5 centimetre of submergence medicine; Soak after 15-20 minute, the slow fire heating changes intense fire after 3-5 minute and boils.From the timing of when boiling and use slow fire instead and continued to boil 45 minutes to one hour, during can add boiling water inadequately like moisture, after the time arrives, filter and remove residue, the acquisition medicinal liquid, natural cooling.
Weight portion in this specific embodiment all is adopted as metric unit: gram.
The drug combination preparation of treatment flu of the present invention; When being prepared into medicament, can add the medicine acceptable auxiliary; Described acceptable accessories comprises diluent, filler (like mannitol, lactose, Polyethylene Glycol) conventional in the preparation, binding agent (starch, microcrystalline Cellulose); Disintegrating agent (like carboxymethyl cellulose, low substituted hydroxypropyl cellulose); Lubricant (like Pulvis Talci, magnesium stearate), wetting agent (like propylene glycol, ethanol), stabilizing agent (EDTA-2Na, sodium thiosulfate, sodium pyrosulfite, sodium sulfite, ethanolamine, sodium bicarbonate, nicotiamide) or the like.Above-mentioned adjuvant can be a common dose, mixes with the main constituent extract with proportioning commonly used, and after main constituent extract consumption was confirmed, the proportioning between each pharmaceutic adjuvant can suitably be regulated as required.
Below, the medicine analysis of pharmacodynamics side and the clinical efficacy experiment of treating the pharmaceutical composition of flu through the present invention further specify good effect of the present invention.
One. Flos Lonicerae, cold in nature, sweet in the mouth, return lung meridian,
Function: 1. dispelling wind to relieve the exterior syndrome, 2. heat-clearing and toxic substances removing;
In the present invention, two functions of Flos Lonicerae can be used, outward can dispelling wind to relieve the exterior syndrome, interior can heat-clearing and toxic substances removing, indispensable in the treatment anemopyretic cold.Flos Lonicerae consumption in the present invention, the adult can reach 15 grams with more than 10 grams, is lower than 10 and restrains then unsatisfactory curative effect, restrains then injuring spleen-stomach yang-energy greater than 15, is prone to cause loose stool diarrhoea.General low dose of available 5 grams of child 4-10 year consumption, heavy dose can reach 10 grams, and dosage is too small, restrains then less than 5 that curative effect is undesirable, then with the imapirment of the spleen and stomach yang-energy, is prone to cause insufficiency of the spleen diarrhea greater than 10 grams.So adult's consumption 10-15 gram, child's consumption 5-10 gram, this is an effective dose, also is safe dose, has surpassed this safe and effective dosage, otherwise just invalid, otherwise just things turn out contrary to one's wishes.(it is identical with the adult to comprise 11 years old teenager consumption, 1-3 year consumption 1-4 gram more than 11 years old.
Two. Fructus Forsythiae, cold in nature, bitter in the mouth, return lung meridian,
Function: 1. dispelling wind to relieve the exterior syndrome, 2. heat-clearing and toxic substances removing;
In the present invention, the effect of Fructus Forsythiae is identical with Flos Lonicerae, but outer dispelling wind to relieve the exterior syndrome, but interior heat-clearing and toxic substances removing is compatible with Flos Lonicerae, has strengthened the effect of dispelling wind to relieve the exterior syndrome, the powerful effect of heat-clearing and toxic substances removing.The general 10-15 gram of its consumption adult is lower than 10 heterodynes, then is prone to cause the damage of taste yang-energy greater than 15 grams, is prone to cause the loose stool and has loose bowels.4-10 year child minimum dose is 5 grams, and maximal dose is 10 grams, is lower than 5 to restrain then heterodyne, is higher than 10 grams and then is prone to cause the damage of taste yang-energy, causes diarrhea.(comprising 11 years old) above teenager consumption was identical with the adult in 11 years old, 1-3 year consumption 1-4 gram.
Three. Herba Houttuyniae, cold in nature, acrid in the mouth, return lung meridian, effect: heat-clearing and toxic substances removing,
Herba Houttuyniae and Flos Lonicerae, Fructus Forsythiae are compatible in the present invention; Common heat-clearing and toxic substances removing, though find that in invention research for many years Herba Houttuyniae, Flos Lonicerae, Fructus Forsythiae can heat-clearing and toxic substances removing, best with the Herba Houttuyniae heat-clearing toxin-expelling functions; It is also the fastest to take effect; The effect of Flos Lonicerae and Fructus Forsythiae heat-clearing and toxic substances removing is inferior to Herba Houttuyniae, and three flavor medicines share, and make the efficacy exertion of heat-clearing and toxic substances removing go out maximum effect.Herba Houttuyniae dosage in the present invention, adult's consumption minimum dose 10 gram, maximal dose 15 grams are lower than 10 and restrain then that effect does not show, and are higher than 15 grams and then are prone to cause the damage of taste yang-energy, cause diarrhea.4-10 year child minimum dose is 5 grams, and maximal dose is 10 grams, is lower than 5 to restrain then heterodyne, is higher than 10 to restrain then easy damaged taste yang-energy, is prone to cause the loose stool and has loose bowels.(comprising 11 years old) above teenager consumption was identical with the adult in 11 years old.Herba Houttuyniae, Flos Lonicerae, Fructus Forsythiae three medicines mutually 5 is used for heat-clearing and toxic substances removing, and be indispensable.If lack simply then affect the treatment, whole prescription all there is harmful effect.1-3 year child consumption 1-4 gram.
Four. Rhizoma Phragmitis, cold in nature, bitter in the mouth, return lung meridian, function: clearing away heat and promoting production of body fluid,
The heresy of wind heat is a YANG pathogen, and normal damage lung Tianjin shows as the thirsty or red tongue with a little fluid of dysphoria with smothery sensation, and Rhizoma Phragmitis has the clearing away heat and promoting production of body fluid dual function, and the effect of strengthening vital QI to eliminate pathogenic factors is arranged, and share with Flos Lonicerae, Fructus Forsythiae, Herba Houttuyniae, strengthens the heat clearing away effect, can nourish the body fluid of lung again.The dosage of Rhizoma Phragmitis in the present invention, adult's consumption minimum dose 10 gram, maximal dose 25 grams are lower than 10 and restrain then heterodyne, are higher than 25 grams and then are prone to cause just rush down.4-10 year child minimum dose is 5 grams, and maximal dose is 10 grams, is lower than 5 to restrain then heterodyne, be higher than 10 grams and then be prone to cause insufficiency of the spleen loose stool, and in this prescription, by this each amount utilization, good effect, and have no side effect safely.
Five. Semen Sterculiae Lychnophorae, cold in nature, sweet in the mouth, function: 1. clear lung qi dispersing gas, 2. relieving sore-throat by clearing away heat,
The evil impairing the lung of wind heat often causes lung qi a surname and falls imbalance, and cough is spat, and the pathogenic heat lung Tianjin of often burning forms yellow sputum and hand over knot with pathogenic heat again conversely, and the lung qi closing are not declared, and common coughing told yellow sputum, the clear lung qi dispersing gas of Semen Sterculiae Lychnophorae.Can make lung qi a surname of closing logical, cough is from ending.The Semen Sterculiae Lychnophorae relieving sore-throat by clearing away heat is in order to the throat discomfort that the treatment anemopyretic cold causes, rather desirable simultaneously.Semen Sterculiae Lychnophorae adult consumption 10-15 gram restrains then weak effect less than 10, also can cause greater than 15 grams and insufficiency of the spleenly just rush down that it is fine that general adult uses 10-15 gram curative effect.4-10 year, child dose was the 5-10 gram, and this is safe and effective dosage, restrained then heterodyne less than 5, then was prone to the loose stool greater than 10 grams and had loose bowels.1-3 year child consumption 1-4 gram.The treatment anemopyretic cold must be with the clear lung qi dispersing gas of Semen Sterculiae Lychnophorae, and other drug does not have the function of clear lung qi dispersing gas, does not have other medicines can replace Semen Sterculiae Lychnophorae.
Six. Semen Armeniacae Amarum (peeling), property is wet, bitter in the mouth, slightly poisonous, effect: the sending down the abnormal ascending QI cough-relieving,
The heresy of wind heat is prone to cause the living expectorant in Tianjin that burns in the anemopyretic cold, blocks mechanism of qi.Cause abnormal rising of lung-QI cough, the Semen Armeniacae Amarum merit is in the sending down the abnormal ascending QI cough-relieving, and in the symptoms such as the cough of holding concurrently at anemopyretic cold, the sending down the abnormal ascending QI cough-relieving is best with Semen Armeniacae Amarum effectiveness, though other medicines can cough-relieving, yet its effect is neither like Semen Armeniacae Amarum.Semen Armeniacae Amarum matter profit can damage lung Tianjin lung yin; Semen Armeniacae Amarum is warm in nature; Yet among the present invention compatibility be several times as much as the cool nature medicine thing of Semen Armeniacae Amarum dosage, thereby the warm nature of Semen Armeniacae Amarum offset by the medicine of cold and cool property, and can not influence the effect of cool nature medicine thing in we; The warm nature that is to say this Semen Armeniacae Amarum has not existed, and has better brought into play the effect of its sending down the abnormal ascending QI cough-relieving on the contrary.In this prescription, have no medicine can replace the effect of the sending down the abnormal ascending QI cough-relieving of Semen Armeniacae Amarum.Semen Armeniacae Amarum and Semen Sterculiae Lychnophorae a surname one in the present invention fall, and it is right to constitute the good medicine of a consequent pole, in the cough of treatment anemopyretic cold; Must also must lack its any Herba indigoferae Pseudotinctoriae with the clear lung qi dispersing gas of Semen Sterculiae Lychnophorae with the cough-relieving of Semen Armeniacae Amarum sending down the abnormal ascending QI; Its antitussive action all will be had a greatly reduced quality, even invalid.Semen Armeniacae Amarum dosage adult in the present invention is the 5-10 gram, and 4-10 year child is that 3-5 restrains, and 11 years old (comprising 11 years old), above teenager consumption was identical with the adult.Because Semen Armeniacae Amarum is slightly poisonous, so must be the Semen Armeniacae Amarum dosage control in safe and effective scope.Adult's dosage is then invalid less than 5 grams, and restraining then toxicity greater than 10 increases, 4-10 year child dose restrain then heterodyne less than 3, restrain then greater than 5 that toxicity strengthens, 1-3 year child is difficult for taking Semen Armeniacae Amarum.If must take, must under physician guidance, take.One-year-old child's 1 gram, two years old child's 2 gram, 3 years old child's 3 gram.1-3 year child 1-2 gram dosage.
Seven. Bulbus Fritillariae Cirrhosae, cold in nature, bitter but sweet flavor, return lung meridian, function 1. removing heat-phlegm, 2. nourishing the lung to arrest cough,
Symptoms such as the heresy of wind heat is prone to impairing the lung Tianjin lung yin, dryness of the lung dry cough can occur, and dry tongue is thirsty, the heresy of existing sometimes wind heat has the heresy of wind-dryness again; Both are mutually double to invade table and attacks lung, and the Bulbus Fritillariae Cirrhosae removing heat-phlegm symptoms such as the dry cough dry tongue is thirsty appear, in damage lung Tianjin lung yin; The moistening the lung and resolving phlegm cough-relieving can removing heat-phlegm, again can be nourshing Yin and drynsessmoistening prescription, but also cough-relieving; Be used for coughing of lung Tianjin lung yin damage, curative effect is splendid, and the medicine of other nourishing the lung to arrest cough is also arranged certainly, but does not all have the Bulbus Fritillariae Cirrhosae good effect.Bulbus Fritillariae Cirrhosae is at dosage of the present invention adult 10-15 gram, and amount restrains then heterodyne less than 10, is prone to cause taste yang-energy loose stool greater than 15 grams, and 4-10 year child dose 5-10 gram restrains then heterodyne less than 5, restrains then easy damaged taste yang-energy greater than 10, is prone to cause the loose stool and has loose bowels.
Eight. Radix Ophiopogonis, cold in nature, bitter but sweet flavor, return lung meridian, function: 1. lung heat clearing pathogenic fire reducing, 2. nourshing Yin and drynsessmoistening prescription,
Evil damage lung Tianjin lung yin of wind heat forms hyperactivity of YANG due to deficiency of YIN, perhaps asthenic fire, and damage lung Tianjin lung yin further again forms vicious cycle afterwards.Symptom curative effects such as Radix Ophiopogonis is the lung heat clearing pathogenic fire reducing both, and is nourshing Yin and drynsessmoistening prescription again, treats the deficient dry cough of lung Tianjin lung yin, and dry tongue is thirsty are splendid.Though also there is the other drug can the lung heat clearing pathogenic fire reducing, nourshing Yin and drynsessmoistening prescription, curative effect be neither like Radix Ophiopogonis.The dosage of the Radix Ophiopogonis dosage of in this prescription, being grown up is 10-15 gram, and amount restrains then weak effect less than 10, is prone to the loose stool greater than 15 grams and rushes down.4-10 year, child dose was the 5-10 gram, restrained then heterodyne less than 5, was prone to the loose stool greater than 10 grams.(comprising 11 years old) above teenager consumption was identical with the adult in 11 years old.
Nine. Fructus Canarii, cold in nature, sweet in the mouth is sour, function: the relieving sore-throat by clearing away heat cough-relieving,
Wind heat is attacked lung, often causes throat discomfort, or causes laryngopharynx swelling and pain, and the Fructus Canarii relieving sore-throat by clearing away heat can make throat comfortable.Fructus Canarii and Semen Sterculiae Lychnophorae be 5 common relieving sore-throat by clearing away heat mutually, heighten the effect of a treatment, and cough-relieving.Fructus Canarii 5 Semen Sterculiae Lychnophoraes 5 can make throat discomfort, laryngopharynx swelling and pain disappear with medicines such as Flos Lonicerae, Fructus Forsythiae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae, Rhizoma Phragmitis, Semen Armeniacae Amarum, Radix Ophiopogonis, and are very important in the present invention.Fructus Canarii is dosage in the present invention, is grown up to be the 10-15 gram, restrains then heterodyne less than 10, restrains then easy damaged taste yang-energy greater than 15, and 4-10 year child minimum dose is 5 grams, and maximal dose is 10 grams, restrains then heterodyne less than 5, restrains then injuring spleen-stomach yang-energy greater than 10, is prone to cause the loose stool.(comprising 11 years old) above teenager consumption was identical with the adult in 11 years old.
All medicines of the present invention, the dosage 1-3 of every flavor medicine gram are applicable to 1-3 year child, but Semen Armeniacae Amarum is slightly poisonous, and 1-3 year child should not use or careful usefulness, as using, please instructs down the doctor and uses.Clear thinking of the present invention, compatibility is tight accurately, and any Herba indigoferae Pseudotinctoriae all can not lack, and lacking simply then curative effect will have a greatly reduced quality.
Typical case's case history:
Case 1.
Liu x man 5 years old,
The patient examined on May 17th, 2008, and its female generation tells, infant heating flu 5 days; Originally infant heating aversion to wind blows, and its mother thinks it is flu, is in and obeys the sheet of bringing down a fever to infant; Heat is stepped back, and hour again fever presenting again goes to certain children's hospital to go to a doctor so its mother takes infant; Through two days infusion treatments, it is normal that infant recovers.Unexpectedly, yesterday, afternoon, infant was played soccer with his father, had gone out many antiperspirant, and the bathing in evening is sleeping; To the time after midnight infant begin heating again, and begin to occur cough, expectoration is sticky; So its father and mother take infant and go to hospital admission, obey the sheet of bringing down a fever to infant simultaneously, toss about in bed to come here to morning today and see a doctor.Look into: infant heating anemophobia, in time, cough, glutinous expectorant of expectoration and yellow thick in bulk, respiratory murmur increases slightly, and X-ray film shows increased bronchovascular shadows, 38.6 degrees centigrade of body temperature, yellow and thin fur, tongue tip side of red, floating and rapid pulse.
Diagnosis: anemopyretic cold is followed acute tracheitis,
Rule: dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing;
The pharmaceutical composition that the treatment of use is caught a cold is: Flos Lonicerae 5 restrains, Fructus Forsythiae 5 restrains, Herba Houttuyniae 5 restrains, Rhizoma Phragmitis 10 restrains, Bulbus Fritillariae Cirrhosae 5 restrains, restrain Radix Ophiopogonis 5, Fructus Canarii 5 restrains, Semen Sterculiae Lychnophorae 5 restrains, Semen Armeniacae Amarum (peeling) 5 restrains;
Three doses, decoction, every day twice, sooner or later respectively once, cool clothes.
Curative effect: infant is taken medicine first and was begun to bring down a fever in 1 hour, and heat has been moved back to the greatest extent about 5 hours, not recurrence, obey three doses of medicines after, all disease disappearances are fully recovered.
Case 2.
Chinese mugwort xx woman 6 years old,
Infant was examined in December in 2009 on the 18th, and the head of a family tells in generation.Infant yesterday evening feels under the weather, the sleep in evening early, to about the three in morning, the head of a family strokes infant, finds that infant heating, aversion to wind blow, so anxious band infant is examined.Infant heating anemophobia, soft little cough, 38.9 degrees centigrade of body temperature, a little turbid tears of nose stream are looked the tonsil redness, yellow and thin fur, tongue tip side of red, floating and rapid pulse.
Diagnosis: the concurrent tonsillitis of anemopyretic cold,
Rule: dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing,
The pharmaceutical composition that the treatment of use is caught a cold is: Flos Lonicerae 7 grams, Fructus Forsythiae 7 grams, Herba Houttuyniae, 7 restrain, Rhizoma Phragmitis 10 restrains, restrain Radix Ophiopogonis 7, Semen Sterculiae Lychnophorae 7 restrains, Fructus Canarii 7 restrains, Bulbus Fritillariae Cirrhosae 7 restrains, Semen Armeniacae Amarum (peeling) 5 restrains;
Three doses, decoction, every day potion, sooner or later each once, cool clothes;
Explain: here has and processes herb liquid, makes infant obey immediately down, and after two hours, infant begins to bring down a fever, and goes out slight perspiration, and about about 5 hours, heat took off to the greatest extent, and bounce-back recurrence advises its head of a family to make infant serve on three days, and infants ' parents is accused and said after three days: good
Case 3.
Opened the x man 39 years old,
The patient examined on April 11st, 2010, and readme cold cough+many all can be caught a cold once every year in the past, the especially severe of catching a cold specifically this year, sensation heating anemophobia; Cough is violent, and it is mute to cough hoarseness, accidental sputum mixed with blood silk, and chest pain is indistinct when coughing, and looks into: patient's anemophobia that generates heat; Cough is again and again coughed and is told yellow sputum and have a little the blood streak, and respiratory murmur increases slightly, 37.8 degrees centigrade of body temperature; X-ray film shows increased bronchovascular shadows, yellow and thin fur, tongue tip side of red, floating and rapid pulse.
Diagnosis: the concurrent pneumonia of anemopyretic cold,
Rule: dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing,
The pharmaceutical composition that the treatment of use is caught a cold is: Flos Lonicerae 10 restrains, Fructus Forsythiae 10 restrains, Herba Houttuyniae 10 restrains, Rhizoma Phragmitis 10 restrains, Semen Sterculiae Lychnophorae 10 restrains, Fructus Canarii 10 restrains, Bulbus Fritillariae Cirrhosae 10 restrains, restrain Radix Ophiopogonis 10, Semen Armeniacae Amarum (peeling) 10 restrains;
Three doses, decoction, every day potion, sooner or later each once, cool clothes.
Curative effect: patient's after heat of taking medicine is moved back, and takes medicine altogether three days, and all diseases disappear clinical cure.
Case 4.
Woods xx woman 60 years old,
The patient examined on May 11st, 2011, patient's readme cold, fever rhinorrhea, throat pain one day.Careful inquiry, the patient informs, except above-mentioned all diseases, also with cough.Cough and tell glutinous expectorant, throat is uncomfortable, and pain.Look into: 38.7 degrees centigrade of patient temperatures, look patient's pharyngitis, yellow and thin fur, tongue tip side of red, floating and rapid pulse.
Diagnosis: the concurrent acute pharyngolaryngitis of anemopyretic cold,
Rule: dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing;
The pharmaceutical composition of the treatment flu of using is: Flos Lonicerae 15 grams, Fructus Forsythiae 15 grams, Herba Houttuyniae 15 grams, Semen Sterculiae Lychnophorae 15 grams, Bulbus Fritillariae Cirrhosae 15 grams, Rhizoma Phragmitis 25 grams, Fructus Canarii 15 gram grams Radix Ophiopogonis 15, Semen Armeniacae Amarum (peeling) 10 grams;
Two doses, decoction, every day potion, sooner or later each once, cool clothes.
Curative effect: the patient obeys the hot benzonatate of potion and ends, obey two doses after, all diseases disappear, and fully recover.
After the preferred embodiment that specifies; Being familiar with this technological personage can be well understood to; Do not break away from above-mentioned claim with spirit under can carry out various variations and modification; All foundations technical spirit of the present invention all belongs to the scope of technical scheme of the present invention to any simple modification, equivalent variations and modification that above embodiment did.And the embodiment that the present invention also is not subject in the description to be given an actual example.
Claims (5)
1. pharmaceutical composition of treating flu; It is characterized in that it is to be processed by following raw materials in weight portion medicine: Flos Lonicerae 3-15 part, Fructus Forsythiae 3-15 part, Herba Houttuyniae 3-15 part, Rhizoma Phragmitis 7-25 part, Semen Sterculiae Lychnophorae 3-15 part, Bulbus Fritillariae Cirrhosae 3-15 part, Fructus Canarii 3-15 part, Radix Ophiopogonis 3-15 part, Semen Armeniacae Amarum 1-10 part.
2. the pharmaceutical composition that said treatment is caught a cold like claim 1; It is characterized in that it is to be processed by following raw materials in weight portion medicine: 5 parts of Flos Loniceraes, 5 parts of Fructus Forsythiaes, 5 parts of Herba Houttuyniae, 9 parts of Rhizoma Phragmitiss, 5 parts of Semen Sterculiae Lychnophoraes, 9 parts of Bulbus Fritillariae Cirrhosaes, 9 parts of Fructus Canariis, 5 parts of Radix Ophiopogonis, 5 parts in Semen Armeniacae Amarum.
3. the pharmaceutical composition that said treatment is caught a cold like claim 1; It is characterized in that it is to be processed by following raw materials in weight portion medicine: 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Herba Houttuyniae, 25 parts of Rhizoma Phragmitiss, 15 parts of Semen Sterculiae Lychnophoraes, 15 parts of Bulbus Fritillariae Cirrhosaes, 15 parts of Fructus Canariis, 15 parts of Radix Ophiopogonis, 10 parts in Semen Armeniacae Amarum.
4. like the pharmaceutical composition of the said treatment flu of claim 1, it is characterized in that said Semen Armeniacae Amarum is a blanched almonds.
5. the method for preparing like the oral liquid of the pharmaceutical composition of the described treatment flu of claim 1 comprises the steps:
A. extracting honeysuckle 3-15 part, Fructus Forsythiae 3-15 part, Herba Houttuyniae 3-15 part, Rhizoma Phragmitis 7-25 part, Semen Sterculiae Lychnophorae 3-15 part, Bulbus Fritillariae Cirrhosae 3-15 part, Fructus Canarii 3-15 part, Radix Ophiopogonis, 3-15 part, Semen Armeniacae Amarum 1-10 part were subsequent use;
B. the extraction of extractum I: Flos Lonicerae adds water temperature and soaks secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merges infusion for the second time; Fructus Forsythiae, Rhizoma Phragmitis decocting in water secondary boiled 2 hours with 10-15 times of water gaging for the first time, doubly measured with 6-12 for the second time, and decocting in water 2 hours merges water cooking liquid; Semen Sterculiae Lychnophorae decocting in water secondary boiled 2 hours with 6-12 times of water gaging for the first time, boiled 2 hours with 3-8 times of water gaging for the second time; Merge above-mentioned warm macerating liquid and water cooking liquid, and Bulbus Fritillariae Cirrhosae is added water temperature soak secondary; For the first time with 10-15 times of water gaging warm macerating 1.5 hours; In being filtered in 1 hour with 6-10 times of water gaging warm macerating for the second time, merging is condensed into cream and surveys relative density 1.2-1.3 for 50 ℃, gets extractum I;
The extraction of extractum II: 1. extract volatile oil: get Herba Houttuyniae, Fructus Canarii, Radix Ophiopogonis, Semen Armeniacae Amarum four Chinese medicine material, merge together, add 1～12 times of water gaging; Soak after 0.5～5 hour; Adopted steam distillation 1～8 hour, and collected volatile oil device preservation in addition, medicinal residues continue to extract; 2. extract: the medicinal residues decocte with water behind extraction such as all the other medical materials and Fructus Canarii, Semen Armeniacae Amarum medicinal residues and the Flos Lonicerae volatile oil 1～3 time, decocted 0.5～3 hour at every turn, collecting decoction filters, and filtrating is concentrated into relative density 1.00～1.35 in the time of 50～80 ℃, puts cold; 3. precipitate with ethanol: add ethanol and make and contain the alcohol amount and reach 10～85%, left standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 ℃, get extractum II;
C. dosing: take by weighing extractum I, add water, stir down it was boiled 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 ℃ and kept 2～30 minutes, filter; In an amount of polysorbate, add volatile oil, be stirred to mix homogeneously, get fragrant solution; With above-mentioned three kinds of combining medicine, add water, stir, heated and boiled 5～50 minutes, put cold, to below 80 ℃, then with medical filtration; D. fill, gland, 90～150 ℃ of sterilizations of logical then steam 5～60 minutes promptly get oral liquid.
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| CN104721516A (en) * | 2013-12-19 | 2015-06-24 | 王骁 | Traditional Chinese medicine and preparation method thereof |
| CN104473165A (en) * | 2014-12-05 | 2015-04-01 | 李永胜 | Buccal tablet with honeysuckle flower and fructus forsythiae |
| CN106236909A (en) * | 2016-09-05 | 2016-12-21 | 佛山市顺德区宝铜金属科技有限公司 | A kind of sore-throat relieving Chinese herbal medicine |
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