CN108187075A - A kind of medical supersonic coupled patch preparation method - Google Patents
A kind of medical supersonic coupled patch preparation method Download PDFInfo
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- CN108187075A CN108187075A CN201810270283.XA CN201810270283A CN108187075A CN 108187075 A CN108187075 A CN 108187075A CN 201810270283 A CN201810270283 A CN 201810270283A CN 108187075 A CN108187075 A CN 108187075A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 238000006243 chemical reaction Methods 0.000 claims abstract description 57
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 25
- 239000003999 initiator Substances 0.000 claims abstract description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000008213 purified water Substances 0.000 claims abstract description 21
- 239000000178 monomer Substances 0.000 claims abstract description 20
- 238000004132 cross linking Methods 0.000 claims abstract description 17
- 239000003755 preservative agent Substances 0.000 claims abstract description 14
- 230000002335 preservative effect Effects 0.000 claims abstract description 14
- 238000007493 shaping process Methods 0.000 claims abstract description 13
- 239000011259 mixed solution Substances 0.000 claims abstract description 5
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 239000002253 acid Substances 0.000 claims description 14
- 239000000243 solution Substances 0.000 claims description 12
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 10
- 230000001476 alcoholic effect Effects 0.000 claims description 10
- 159000000000 sodium salts Chemical class 0.000 claims description 9
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 7
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 claims description 6
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims description 6
- 229920000936 Agarose Polymers 0.000 claims description 5
- 238000005260 corrosion Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- ZLVSYODPTJZFMK-UHFFFAOYSA-M sodium 4-hydroxybenzoate Chemical class [Na+].OC1=CC=C(C([O-])=O)C=C1 ZLVSYODPTJZFMK-UHFFFAOYSA-M 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 150000004968 peroxymonosulfuric acids Chemical group 0.000 claims description 2
- 241001474374 Blennius Species 0.000 claims 1
- 238000006356 dehydrogenation reaction Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 7
- 231100001083 no cytotoxicity Toxicity 0.000 abstract description 5
- 239000000523 sample Substances 0.000 abstract description 5
- 206010070834 Sensitisation Diseases 0.000 abstract description 3
- 239000000049 pigment Substances 0.000 abstract description 3
- 230000008313 sensitization Effects 0.000 abstract description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- 238000003756 stirring Methods 0.000 description 12
- 238000007792 addition Methods 0.000 description 8
- 239000007864 aqueous solution Substances 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 230000007062 hydrolysis Effects 0.000 description 6
- 238000006460 hydrolysis reaction Methods 0.000 description 6
- 229920000615 alginic acid Polymers 0.000 description 5
- 229960001126 alginic acid Drugs 0.000 description 5
- 235000010443 alginic acid Nutrition 0.000 description 5
- 239000000783 alginic acid Substances 0.000 description 5
- 150000004781 alginic acids Chemical class 0.000 description 5
- 239000007822 coupling agent Substances 0.000 description 5
- 238000007689 inspection Methods 0.000 description 5
- JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 4
- -1 Methacrylic acid glycol ester Chemical class 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 125000002843 carboxylic acid group Chemical group 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- 238000007334 copolymerization reaction Methods 0.000 description 3
- 230000007797 corrosion Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 238000006073 displacement reaction Methods 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 238000010528 free radical solution polymerization reaction Methods 0.000 description 3
- 230000026030 halogenation Effects 0.000 description 3
- 238000005658 halogenation reaction Methods 0.000 description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 231100001231 less toxic Toxicity 0.000 description 3
- 230000000269 nucleophilic effect Effects 0.000 description 3
- 229920002401 polyacrylamide Polymers 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- UWNADWZGEHDQAB-UHFFFAOYSA-N 2,5-dimethylhexane Chemical group CC(C)CCC(C)C UWNADWZGEHDQAB-UHFFFAOYSA-N 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical class OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- VYBHLZOLHCQLHT-UHFFFAOYSA-N 1-(2-methylpropyl)-4,5-dihydroimidazole hydrochloride Chemical compound Cl.C(C(C)C)N1C=NCC1 VYBHLZOLHCQLHT-UHFFFAOYSA-N 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 150000001409 amidines Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000001513 elbow Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003811 finger Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 210000002832 shoulder Anatomy 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to field of medical technology, in particular a kind of medical supersonic coupled patch preparation method, including following component：Purified water 80% to 85%, reaction monomers 10% to 15%, cross-linking reaction agent 1% to 5%, preservative 0.01% to 0.05% and initiator 0.9% to 1.5%.Including following preparation process：Step 1 prepares reaction monomers and cross-linking reaction agent, and adds in preservative into the mixed solution after the completion of preparation in proportion；Step 2 adds in initiator in through step 1 mixing easily obtained, forms reaction system.Medical supersonic coupled patch prepared by the present invention is to light and thermally stable, to human body no cytotoxicity, to skin without sensitization and nonirritant；Vacuum outgas bubble is not needed to, with regard to patch clear, colorless can be formed；Addition pigment is not required to, therefore ultrasonic probe is not injured；It is easy to use, comfortable, hygienic simultaneously, lead that acoustic performance is excellent, and ultrasonoscopy is clear, it can be with random-shaping.
Description
Technical field
The present invention relates to field of medical technology, specially a kind of medical supersonic coupled patch preparation method.
Background technology
Ultrasonic Diagnosis (ultrasonic diagnosis) is that ultrasonic detecting technology is applied to human body, is understood by measuring
The data and form of physiology or institutional framework find disease, make a kind of diagnostic method of prompting.Ultrasonic Diagnosis is a kind of nothing
Wound, it is painless, conveniently, intuitive effective detection methods, especially B ultrasound, be widely used, influence it is very big, with X ray, CT, magnetic resonance
Imaging and referred to as 4 big Medical Imaging Technologies.
Coupling agent for medical use is a kind of curable product being made of aqueous high molecular gel of new generation.Its pH value is neutrality,
It is non-toxic to humans, drying is not easy, is not easy rancid, ultrasonoscopy is clear, and toughness is suitable, and without greasy, probe is easy to sliding
Dynamic, wettable skin eliminates skin surface air, and greasy property is good, easily spreads out；It is corrosion-free, not damaged to ultrasonic probe；City
Occurs the ultrasonic coupling agent with disinfection function on face, relative to traditional plain edition couplant, for production environment
It is more stringent, applicable range is also more extensively.
But the inspection for eye, arteria carotis, the inspection of eye, arteria carotis, tendon, mammary gland, thyroid gland, subcutaneous tumor,
The inspection of the Minor articulus such as cutaneum carcinoma, the inspection of human body superficial place, finger, wrist, elbow, shoulder, knee, ankle, toe, human body are sensitive, hidden
The inspection at private position, ultrasonic physical therapy and the treatment of ultrasound, the monitoring of operation, during Delivery the monitoring coupling agent for medical use of stages of labor because
It then has no idea to implement for organ construction, skin infection, Minor articulus deformation etc..In consideration of it, a kind of it is proposed that medical supersonic coupling
Close patch preparation method.
Invention content
The purpose of the present invention is to provide a kind of medical supersonic coupled patch preparation method, to solve in above-mentioned background technology
The problem of proposition.
To achieve the above object, the present invention provides following technical solution：
A kind of medical supersonic coupled patch preparation method, including following component：Purified water 80% to 85%, reaction monomers
10% to 15%, cross-linking reaction agent 1% to 5%, preservative 0.01% to 0.05% and initiator 0.9% to 1.5%, including such as
Lower preparation process：
Step 1 prepares reaction monomers and cross-linking reaction agent, and adds in and prevent into the mixed solution after the completion of preparation in proportion
Rotten agent；
Step 2 adds in initiator in through step 1 mixing easily obtained, forms reaction system；
Step 3 will be injected through mixing liquid object to be reacted made from step 2 in shaping die；
The shaping die for being loaded with above-mentioned mixed solution is transferred in heating unit by step 4, in 40~80 DEG C of reaction temperatures
Under, reaction 6~for 24 hours；
Step 5, cooled to room temperature, after reaction cures, demoulding packaging.
As currently preferred, the reaction monomers are alginic acid, methyl methacrylate alcoholic solution, agarose or poly-
Any one in ethylene glycol.
As currently preferred, the cross-linking reaction agent is acrylamide or ethylene glycol dimethacrylate.
As currently preferred, the preservative is dehydroactic acid and sodium salt or paraben esters.
As currently preferred, the initiator is persulfate, water-soluble azo initiator or water-soluble light-initiated
Any one in agent.
Compared with prior art, the beneficial effects of the invention are as follows：
1st, the present invention use degradable preservative, to light and thermally stable, be degraded to acetic acid in aqueous solution, to human body without
Cytotoxicity, it is non-stimulated to skin, without sensitization；
2nd, the present invention does not need to vacuum outgas bubble, forms patch clear, colorless, is not required to addition pigment, ultrasonic probe is not hindered
Evil；
3rd, medical supersonic coupled patch produced by the present invention is easy to use, comfortable, hygienic, and it is excellent to lead acoustic performance, ultrasound figure
, can be with random-shaping as clear, the velocity of sound is 1520 to 1620m/s, and acoustic characteristic impedance is 1.5 × 106 to 1.7 × 106Pa
S/m, acoustic attenuation coefficient slope are not more than 0.05dB/cmMHz.
Specific embodiment
The technical solution in the embodiment of the present invention is clearly and completely described below in conjunction with the embodiment of the present invention,
Obviously, described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, those of ordinary skill in the art's all other embodiments obtained without making creative work, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of preparation method of medical supersonic coupled patch, including following component purified water, reaction monomers, cross-linking reaction
Agent, preservative and initiator.By weight, the ratio that each component accounts for is：Purified water 80%, reaction monomers 15%, cross-linking reaction
Agent 4%, preservative 0.05%, initiator 0.95%, including following preparation process：
Alginic acid is slowly added into purified water by step 1, and stirring is to being completely dissolved, indwelling；
Step 2 is prepared acrylamide and is added in into purified water, and stirring is to being completely dissolved, indwelling；
Step 3 is prepared persulfuric acid acid ammonia and is added in into purified water, and stirring is to being completely dissolved, indwelling；
Step 4 is prepared in the purified water of paraben esters additions, is stirred to being completely dissolved, indwelling；
Step 5 is injected above-mentioned after the mixed liquor reacted stirs evenly in shaping die；
Step 6, the shaping die for being loaded with above-mentioned mixed liquor are transferred in heating unit, under 40 DEG C of reaction temperatures, reaction
24h；
Step 7, cooled to room temperature, after reaction cures, demoulding is packaged to be medical supersonic coupled patch.
In the present embodiment, reaction monomers are preferably alginic acid, methyl methacrylate alcoholic solution, agarose or polyethylene glycol
In any one, it is a variety of organic molten to be dissolved in ethyl alcohol, ether, acetone etc. for further preferably methyl methacrylate alcoholic solution
Agent is slightly soluble in ethylene glycol and water.Light, heat and catalytic action easily polymerize, and can be also copolymerized with other monomers, due to there are double bond and
Carboxylic acid group also easily carries out addition, halogenation, nucleophilic displacement of fluorine core ester exchange reaction；Toxicity is smaller.
In the present embodiment, cross-linking reaction agent be acrylamide or ethylene glycol dimethacrylate, further preferably two
Methacrylic acid glycol ester has it to participate in the polymer of copolymerization, and hardness increases, and heat-resisting, weather-proof, solvent resistant and frictional property carry
It is high.
In the present embodiment, preservative is dehydroactic acid and sodium salt or paraben esters, further preferably dehydroactic acid and
Sodium salt, less toxic efficient corrosion resisting, mould inhibitor.There is certain antibacterial action under the conditions of acid, alkali, especially the inhibition of mould is made
With most by force.To light and thermally stable, it is degraded to acetic acid in aqueous solution, it is non-stimulated to skin, without cause to human body no cytotoxicity
It is quick；
In the present embodiment, initiator is arbitrary in persulfate, water-soluble azo initiator or water-soluble light trigger
One kind, further preferably water-soluble azo initiator, performance is stable, is uniformly dispersed in aqueous solution polymerization.It therefore can be fully
Reaction, dosage is less, easy to use, and preceding hydrolysis and rear hydrolysis can use.The polyacrylamide product viscosity molecule polymerizeing
Measure relatively high (35,000,000-4,000 ten thousand), insoluble matter it is relatively low (<0.2%).
Embodiment 2
A kind of preparation method of medical supersonic coupled patch, including purified water, reaction monomers, cross-linking reaction agent, preservative
And initiator.By weight, the ratio that each component accounts for is：Purified water 85%, reaction monomers 12%, cross-linking reaction agent 2%, anti-corrosion
Agent 0.02%, initiator 0.98%, including following preparation process：
Methyl methacrylate alcoholic solution is slowly added into purified water by step 1, and stirring is to being completely dissolved, indwelling；
Step 2 is prepared acrylamide and is added in into purified water, and stirring is to being completely dissolved, indwelling；
Step 3 is prepared two isobutyl imidazoline hydrochloride of azo and is added in into purified water, and stirring is to being completely dissolved, indwelling；
Step 4 is prepared in the purified water of paraben esters additions, is stirred to being completely dissolved, indwelling；
Step 5 is injected above-mentioned after the mixed liquor reacted stirs evenly in shaping die；
The shaping die for being loaded with above-mentioned mixed liquor is transferred in heating unit by step 6, under 80 DEG C of reaction temperatures, reaction
6h；
Step 7, cooled to room temperature, after reaction cures, demoulding is packaged to be medical supersonic coupled patch.
In the present embodiment, reaction monomers are preferably alginic acid, methyl methacrylate alcoholic solution, agarose or polyethylene glycol
In any one, it is a variety of organic molten to be dissolved in ethyl alcohol, ether, acetone etc. for further preferably methyl methacrylate alcoholic solution
Agent is slightly soluble in ethylene glycol and water.Light, heat and catalytic action easily polymerize, and can be also copolymerized with other monomers, due to there are double bond and
Carboxylic acid group also easily carries out addition, halogenation, nucleophilic displacement of fluorine core ester exchange reaction；Toxicity is smaller.
In the present embodiment, cross-linking reaction agent be acrylamide or ethylene glycol dimethacrylate, further preferably two
Methacrylic acid glycol ester has it to participate in the polymer of copolymerization, and hardness increases, and heat-resisting, weather-proof, solvent resistant and frictional property carry
It is high.
In the present embodiment, preservative is dehydroactic acid and sodium salt or paraben esters, further preferably dehydroactic acid and
Sodium salt, less toxic efficient corrosion resisting, mould inhibitor.There is certain antibacterial action under the conditions of acid, alkali, especially the inhibition of mould is made
With most by force.To light and thermally stable, it is degraded to acetic acid in aqueous solution, it is non-stimulated to skin, without cause to human body no cytotoxicity
It is quick；
In the present embodiment, initiator is arbitrary in persulfate, water-soluble azo initiator or water-soluble light trigger
One kind, further preferably water-soluble azo initiator, performance is stable, is uniformly dispersed in aqueous solution polymerization.It therefore can be fully
Reaction, dosage is less, easy to use, and preceding hydrolysis and rear hydrolysis can use.The polyacrylamide product viscosity molecule polymerizeing
Measure relatively high (35,000,000-4,000 ten thousand), insoluble matter it is relatively low (<0.2%).
Embodiment 3
A kind of preparation method of medical supersonic coupled patch, including purified water, reaction monomers, cross-linking reaction agent, preservative
And initiator.By weight, the ratio that each component accounts for is：Purified water 82%, reaction monomers 13%, are prevented cross-linking reaction agent 3.5%
Rotten agent 0.03%, initiator 1.42%, including following preparation process：
Methyl methacrylate alcoholic solution is slowly added into purified water by step 1, and stirring is to being completely dissolved, indwelling；
Step 2 is prepared ethylene glycol dimethacrylate and is added in into purified water, and stirring is to being completely dissolved, indwelling；
Step 3 is prepared azo diisobutyl amidine hydrochloride and is added in into purified water, and stirring is to being completely dissolved, indwelling；
Step 4 is prepared in the purified water of dehydroactic acid and sodium salt additions, is stirred to being completely dissolved, indwelling；
Step 5 is injected above-mentioned after the mixed liquor reacted stirs evenly in shaping die；
The shaping die for being loaded with above-mentioned mixed liquor is transferred in heating unit by step 6, under 60 DEG C of reaction temperatures, reaction
12h；
Step 7, cooled to room temperature, after reaction cures, demoulding is packaged to be medical supersonic coupled patch.
In the present embodiment, reaction monomers are preferably alginic acid, methyl methacrylate alcoholic solution, agarose or polyethylene glycol
In any one, it is a variety of organic molten to be dissolved in ethyl alcohol, ether, acetone etc. for further preferably methyl methacrylate alcoholic solution
Agent is slightly soluble in ethylene glycol and water.Light, heat and catalytic action easily polymerize, and can be also copolymerized with other monomers, due to there are double bond and
Carboxylic acid group also easily carries out addition, halogenation, nucleophilic displacement of fluorine core ester exchange reaction；Toxicity is smaller.
In the present embodiment, cross-linking reaction agent be acrylamide or ethylene glycol dimethacrylate, further preferably two
Methacrylic acid glycol ester has it to participate in the polymer of copolymerization, and hardness increases, and heat-resisting, weather-proof, solvent resistant and frictional property carry
It is high.
In the present embodiment, preservative is dehydroactic acid and sodium salt or paraben esters, further preferably dehydroactic acid and
Sodium salt, less toxic efficient corrosion resisting, mould inhibitor.There is certain antibacterial action under the conditions of acid, alkali, especially the inhibition of mould is made
With most by force.To light and thermally stable, it is degraded to acetic acid in aqueous solution, it is non-stimulated to skin, without cause to human body no cytotoxicity
It is quick；
In the present embodiment, initiator is arbitrary in persulfate, water-soluble azo initiator or water-soluble light trigger
One kind, further preferably water-soluble azo initiator, performance is stable, is uniformly dispersed in aqueous solution polymerization.It therefore can be fully
Reaction, dosage is less, easy to use, and preceding hydrolysis and rear hydrolysis can use.The polyacrylamide product viscosity molecule polymerizeing
Measure relatively high (35,000,000-4,000 ten thousand), insoluble matter it is relatively low (<0.2%).
The medical supersonic coupled patch that above 3 groups of embodiments are obtained and traditional coupling agent for medical use carry out contrast experiment's number
According to comparison, data are as follows：
Can show that the present invention is degradable relative to traditional coupling agent for medical use by the comparison of above-mentioned experimental data, to light and
Thermostabilization, to human body without no cytotoxicity, to skin without sensitization and nonirritant；Vacuum outgas bubble is not needed to, just can form patch
Piece clear, colorless；Addition pigment is not required to, therefore ultrasonic probe is not injured；It is easy to use, comfortable, hygienic simultaneously, lead acoustic performance
Excellent, ultrasonoscopy is clear, can be with random-shaping.
Basic principle, main feature and the advantages of the present invention of the present invention has been shown and described above.The technology of the industry
For personnel it should be appreciated that the present invention is not limited to the above embodiments, described in the above embodiment and specification is only the present invention
Preference, be not intended to limit the present invention, without departing from the spirit and scope of the present invention, the present invention also have it is various
Changes and improvements, these changes and improvements all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by institute
Attached claims and its equivalent thereof.
Claims (5)
1. a kind of medical supersonic coupled patch preparation method, it is characterised in that：Including following component：Purified water 80% to 85%,
Reaction monomers 10% to 15%, cross-linking reaction agent 1% to 5%, preservative 0.01% to 0.05% and initiator 0.9% to
1.5%, including following preparation process：
Step 1 prepares reaction monomers and cross-linking reaction agent, and adds in anti-corrosion into the mixed solution after the completion of preparation in proportion
Agent；
Step 2 adds in initiator in through step 1 mixing easily obtained, forms reaction system；
Step 3 will be injected through mixing liquid object to be reacted made from step 2 in shaping die；
The shaping die for being loaded with above-mentioned mixed solution is transferred in heating unit by step 4, under 40~80 DEG C of reaction temperatures, instead
Answer 6~for 24 hours；
Step 5, cooled to room temperature, after reaction cures, demoulding packaging.
2. medical supersonic coupled patch preparation method according to claim 1, it is characterised in that：The reaction monomers are seaweed
Any one in acid, methyl methacrylate alcoholic solution, agarose or polyethylene glycol.
3. medical supersonic coupled patch preparation method according to claim 2, it is characterised in that：The cross-linking reaction agent is third
Acrylamide or ethylene glycol dimethacrylate.
4. medical supersonic coupled patch preparation method according to claim 2, it is characterised in that：The preservative is dehydrogenation second
Acid and sodium salt or paraben esters.
5. medical supersonic coupled patch preparation method according to claim 2, it is characterised in that：The initiator is persulfuric acid
Any one in salt, water-soluble azo initiator or water-soluble light trigger.
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| CN201810270283.XA CN108187075A (en) | 2018-03-29 | 2018-03-29 | A kind of medical supersonic coupled patch preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810270283.XA CN108187075A (en) | 2018-03-29 | 2018-03-29 | A kind of medical supersonic coupled patch preparation method |
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| CN108187075A true CN108187075A (en) | 2018-06-22 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109793902A (en) * | 2019-03-26 | 2019-05-24 | 中国人民大学 | A kind of solid gel piece and the preparation method and application thereof |
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| CN113950292A (en) * | 2019-06-25 | 2022-01-18 | 3M创新有限公司 | Ultrasonic coupling device |
| CN114376616A (en) * | 2022-03-23 | 2022-04-22 | 聚融医疗科技(杭州)有限公司 | Acoustically transparent coupling device, preparation method thereof and mammary gland ultrasonic diagnosis equipment |
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Application publication date: 20180622 |