CN105330786A - Ultrasonic coupling dielectric material for treatment and preparation method thereof - Google Patents
Ultrasonic coupling dielectric material for treatment and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an ultrasonic coupling dielectric material for treatment and a preparation method thereof. The raw materials for preparation of the material include a monomer, a crosslinking agent, a reducing agent for initiating the reaction, an oxidant for initiating the reaction, an organic solvent and water. The monomer is one selected form the group comprising methyl acrylamide, methylacrylic acid, acrylamide, acrylic acid, and acrylate derivatives. The ultrasonic coupling dielectric material for treatment is a jelly polymer gel, and is not easy to generate bubbles in the preparation process; and the ultrasonic coupling dielectric material for treatment can keep a stable, non-liquefied and non-thinning state under the effect of focused ultrasound, has good acoustic performance. The invention solves the complexity of deionized degassing water in the prior art, reduces the complexity of ultrasound equipment, reduces the equipment cost, and enlarges the range of use of the equipment.
Description
Technical field
The invention belongs to concentration ultrasonic therapy equipment technical field, be specifically related to one and treat with ultrasonic coupling dielectric material and preparation method thereof.
Background technology
Focusing ultrasonic therapeutic apparatus is novel non-invasive therapy instrument, ultrasonic energy can be focused on certain region by it, make the tissue at focus place produce irreversible coagulation necrosis by hyperacoustic heat effect, cavitation effect and mechanical effect, and do not injure the healthy tissues of ultrasonic process.Because the frequency of focus supersonic higher (generally at more than 2MHZ) can not be propagated in atmosphere, couplant ability output ultrasonic wave must be passed through, so ultrasonic device uses deionised degassed water to serve as couplant usually.In order to keep the good entrant sound effect of focus supersonic also must constantly circulate and change deionised degassed water, deionised degassed water uses trouble, and equipment is complicated, high expensive.
Also use Macromolecule gelatin substance for couplant in prior art, usually select polyacrylamide hydrophilic gel, serve as the medium for the treatment of head energy output, allow ultrasonic wave effectively export.Polyacrylamide hydrophilic gel uses water as solvent usually, but solvent water is volatile, thus causes gel hardening, and then entrant sound effect also can decline gradually.And easily make polyacrylamide hydrophilic gel produce bubble due to the mechanical effect of focus supersonic and cavitation effect, hinder the output of focus supersonic.
Summary of the invention
Technical problem to be solved by this invention is for above shortcomings in prior art, one is provided to treat with ultrasonic coupling dielectric material and preparation method thereof, this couplant has good entrant sound, stable performance under the effect of focus supersonic, do not liquefy, not thinning.
Solve technical scheme that the technology of the present invention problem adopts to be to provide one and to treat and use ultrasonic coupling dielectric material, its formula comprises: the reductive agent of monomer, linking agent, initiation reaction, the oxygenant of initiation reaction, organic solvent and water, wherein, described monomer is any one in Methacrylamide, methacrylic acid, acrylamide, vinylformic acid, acrylate derivative.The treatment ultrasonic coupling dielectric material obtained is the polymer gel of g., jelly-like.Resultant is obtained after the reductive agent of the initiation reaction in formula, the oxygenant generation redox reaction of initiation reaction, the bond rupture of this resultant meeting trigger monomer, there is crosslinking reaction in monomer simultaneously under the effect of linking agent, final obtained treatment ultrasonic coupling dielectric material.
Preferably, described treatment ultrasonic coupling dielectric material formula composition comprises: the mass percent of described monomer is 5 ~ 60%, the mass percent of described linking agent is 0.03 ~ 0.3%, the mass percent of the reductive agent of described initiation reaction is 0.02 ~ 0.1%, the mass percent of the oxygenant of described initiation reaction is 0.03 ~ 0.15%, the mass percent of described organic solvent is 30 ~ 90%, and the mass percent of described water is 3 ~ 25%.
By controlling the consumption of linking agent and monomer, regulate the product hardness finally obtained.
By controlling the consumption of the Oxidizing and Reducing Agents of initiation reaction, the speed of telo merization.
Preferably, described acrylate derivative is any one in methyl acrylate, ethyl propenoate, propyl acrylate, butyl acrylate, amyl acrylate.
Preferably, described organic solvent is ethylene glycol or glycerol.
Preferably, described linking agent is N, N '-methylene-bisacrylamide.The effect of this linking agent forms tridimensional network after making acrylamide generation crosslinking reaction, makes reacted product not flow and keep definite shape.
Preferably, the reductive agent of described initiation reaction is for laying particular stress on sulphite and/or sulphite.
Preferably, described in lay particular stress on sulphite be Sodium Metabisulfite and/or potassium metabisulfite, described sulphite is sodium bisulfite and/or Potassium hydrogen sulfite.
Preferably, the oxygenant of described initiation reaction is persulphate and/or benzoyl peroxide.
Preferably, described persulphate is ammonium persulphate and/or Potassium Persulphate.
Preferably, 20 ~ 40 DEG C time, when the ultrasonic wave of focusing ultrasonic therapeutic apparatus is propagated in this treatment ultrasonic coupling dielectric material, the velocity of sound is 1480 ~ 1680m/s, and specific acoustic impedance is 1.2 × 10
6~ 2.0 × 10
6pas/m, acoustic attenuation coefficient is 0.05 ~ 1.0dB/cmMHz.
The present invention also provides the preparation method of the treatment ultrasonic coupling dielectric material described in more than one, comprises the following steps:
(1) monomer is dissolved in organic solvent, add the linking agent making described monomer crosslinked reaction again, carry out degassed process until completely dissolved, wherein, described monomer is any one in Methacrylamide, methacrylic acid, acrylamide, vinylformic acid, acrylate derivative;
A large amount of microbubble can be produced in the mixing process of above-mentioned monomer, organic solvent, linking agent, if do not carried out degassed process, so after monomer generation crosslinking reaction is solidified, these microbubbles are set in clear gel hyperacoustic conduction that can hinder focusing ultrasonic therapeutic apparatus, affect result for the treatment of, and can because hyperacoustic conduction is not smooth, and it is hot to generate heat, affect the work-ing life of equipment, so need to carry out degassed process.
(2) by the reductive agent of initiation reaction and the oxygenant of initiation reaction soluble in water, then carry out degassed process;
A large amount of microbubble can be produced in the mixing process of the reductive agent of above-mentioned initiation reaction, the oxygenant of initiation reaction, if do not carried out degassed process, so after monomer generation crosslinking reaction is solidified, these microbubbles can hinder hyperacoustic conduction of focusing ultrasonic therapeutic apparatus, affect result for the treatment of, and can because hyperacoustic conduction is not smooth, and it is hot to generate heat, affect the work-ing life of equipment, so need to carry out degassed process.
(3) solution that step (1) and step (2) obtain is mixed, obtain the polymer gel of the g., jelly-like being used as treatment ultrasonic coupling dielectric material.
The present invention reacts produce free radical, free radical trigger monomer scission of link by causing reductive agent and initiated oxidation agent, then with the polyreaction of linking agent generation interlock type, the final clear gel forming tridimensional network.Due to the present invention's employing is that redox reaction produces free radical, does not need to heat (more than 50 DEG C) and provides the energy of activation needed for scission of link, so can react at lesser temps (5 ~ 30 DEG C).So both facilitate the synthesis for the treatment of ultrasonic coupling dielectric material, also protect the transmitter unit of focusing ultrasonic therapeutic apparatus not by the infringement of high temperature.
Preferably, the vacuum tightness of the degassed process in described step (1) is-0.095 ~-0.08Mpa;
The vacuum tightness of the degassed process in described step (2) is-0.095 ~-0.08Mpa.
Treatment ultrasonic coupling dielectric material in the present invention is mainly used in the output coupling between the ultrasound emission unit of focusing ultrasonic therapeutic apparatus and sound transmitting window, and its feature is that entrant sound is effective, stable performance.Solve in prior art and use the loaded down with trivial details of deionization de aerated water, expand use range, reduce equipment complexity, reduce equipment cost.
Embodiment
For making those skilled in the art understand technical scheme of the present invention better, below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1
The present embodiment provides a kind of composition of raw materials for the treatment of with prepared by ultrasonic coupling dielectric material to comprise: the reductive agent of acrylamide, the linking agent that described acrylamide crosspolymer is reacted, initiation reaction, the oxygenant of initiation reaction, organic solvent and water.
The present embodiment provides a kind of preparation method of above-mentioned treatment ultrasonic coupling dielectric material, comprises the following steps:
(1) acrylamide is dissolved in organic solvent, then adds the linking agent that described acrylamide crosspolymer is reacted, then carry out degassed process;
(2) by the reductive agent of initiation reaction and the oxygenant of initiation reaction soluble in water, then carry out degassed process;
(3) described step (1) and described step (2) are obtained solution mixing, obtain medical treatment and use ultrasonic coupling dielectric material.
20 DEG C time, when the ultrasonic wave of focusing ultrasonic therapeutic apparatus is propagated in this treatment ultrasonic coupling dielectric material, the velocity of sound is 1520m/s, and specific acoustic impedance is 1.7 × 10
6pas/m, acoustic attenuation coefficient is 0.5dB/cmMHz.This treatment ultrasonic coupling dielectric material reaches the national standard of medical ultrasonic coupling agent.
Embodiment 2
The present embodiment provides a kind of and treats consisting of of the composition of raw materials prepared with ultrasonic coupling dielectric material: the mass percent of Methacrylamide is 5%, the mass percent of the linking agent of Methacrylamide crosslinking reaction is made to be 0.03%, the mass percent of the reductive agent Sodium Metabisulfite of initiation reaction is 0.05%, the mass percent of the oxygenant benzoyl peroxide of initiation reaction is 0.05%, the mass percent of organic solvent ethylene glycol is 90%, and the mass percent of water is 4.87%.
The present embodiment provides a kind of preparation method of above-mentioned treatment ultrasonic coupling dielectric material, comprises the following steps:
(1) Methacrylamide is dissolved in organic solvent ethylene glycol, add the linking agent making Methacrylamide crosslinking reaction again, then carry out degassed process, wherein, the vacuum tightness of degassed process is-0.0095Mpa, and the time of degassed process is 20 minutes ~ 2 hours;
(2) by the reductive agent Sodium Metabisulfite of initiation reaction and the oxygenant benzoyl peroxide of initiation reaction soluble in water, then degassed process is carried out, wherein, the vacuum tightness of degassed process is-0.0095Mpa, and the time of degassed process is 20 minutes ~ 2 hours;
(3) step (1) and step (2) are obtained solution mixing, obtain medical treatment and use ultrasonic coupling dielectric material.
30 DEG C time, when the ultrasonic wave of focusing ultrasonic therapeutic apparatus is propagated in this treatment ultrasonic coupling dielectric material, the velocity of sound is 1480m/s, and specific acoustic impedance is 1.6 × 10
6pas/m, acoustic attenuation coefficient is 1.0dB/cmMHz.This treatment ultrasonic coupling dielectric material reaches the national standard of medical ultrasonic coupling agent.
Embodiment 3
The present embodiment provides a kind of and treats consisting of of the composition of raw materials prepared with ultrasonic coupling dielectric material: acrylic acid mass percent is 40%, make the linking agent N of vinylformic acid crosslinking reaction, the mass percent of N '-methylene bisacrylamide acid is 0.08%, the mass percent of the reductive agent Potassium hydrogen sulfite of initiation reaction is 0.02%, the mass percent of the oxygenant ammonium persulphate of initiation reaction is 0.03%, the mass percent of organic solvent glycerol is 50%, and the mass percent of water is 9.87%.
The present embodiment provides a kind of preparation method of above-mentioned treatment ultrasonic coupling dielectric material, comprises the following steps:
(1) vinylformic acid is dissolved in organic solvent glycerol, then adds the linking agent N making vinylformic acid crosslinking reaction, N '-methylene bisacrylamide acid, then degassed process is carried out, wherein, the vacuum tightness of degassed process is-0.085Mpa, and the time of degassed process is 20 minutes ~ 2 hours;
(2) by the reductive agent Potassium hydrogen sulfite of initiation reaction and the oxygenant ammonium persulphate of initiation reaction soluble in water, then carry out degassed process, wherein, the vacuum tightness of degassed process is-0.085Mpa, and the time of degassed process is 20 minutes ~ 2 hours;
(3) step (1) and step (2) are obtained solution mixing, obtain medical treatment and use ultrasonic coupling dielectric material.
40 DEG C time, when the ultrasonic wave of focusing ultrasonic therapeutic apparatus is propagated in this treatment ultrasonic coupling dielectric material, the velocity of sound is 1600m/s, and specific acoustic impedance is 2.0 × 10
6pas/m, acoustic attenuation coefficient is 0.25dB/cmMHz.This treatment ultrasonic coupling dielectric material reaches the national standard of medical ultrasonic coupling agent.
Embodiment 4
The present embodiment provides a kind of and treats consisting of of the composition of raw materials prepared with ultrasonic coupling dielectric material: the mass percent of methyl acrylate is 28%, make the linking agent N of methyl acrylate crosslinking reaction, the mass percent of N '-methylene bisacrylamide acid methyl esters is 0.1%, the reductive agent sodium bisulfite of initiation reaction and the total mass percent of Potassium hydrogen sulfite are 0.03% (wherein, the mass ratio of sodium bisulfite and Potassium hydrogen sulfite is 2:1), the mass percent of the oxygenant Potassium Persulphate of initiation reaction is 0.07%, the mass percent of organic solvent ethylene glycol is 60%, the mass percent of water is 11.8%.
The present embodiment provides a kind of preparation method of above-mentioned treatment ultrasonic coupling dielectric material, comprises the following steps:
(1) methyl acrylate is dissolved in organic solvent ethylene glycol, add the linking agent N making methyl acrylate crosslinking reaction again, N '-methylene bisacrylamide acid methyl esters, then degassed process is carried out, wherein, the vacuum tightness of degassed process is-0.08Mpa, and the time of degassed process is 20 minutes ~ 2 hours;
(2) by the reductive agent sodium bisulfite of initiation reaction and the oxygenant Potassium Persulphate of Potassium hydrogen sulfite and initiation reaction soluble in water, then degassed process is carried out, wherein, the vacuum tightness of degassed process is-0.08Mpa, and the time of degassed process is 20 minutes ~ 2 hours;
(3) step (1) and step (2) are obtained solution mixing, obtain medical treatment and use ultrasonic coupling dielectric material.
20 DEG C time, when the ultrasonic wave of focusing ultrasonic therapeutic apparatus is propagated in this treatment ultrasonic coupling dielectric material, the velocity of sound is 1680m/s, and specific acoustic impedance is 1.6 × 10
6pas/m, acoustic attenuation coefficient is 0.65dB/cmMHz.This treatment ultrasonic coupling dielectric material reaches the national standard of medical ultrasonic coupling agent.
Embodiment 5
The present embodiment provides a kind of and treats consisting of of the composition of raw materials prepared with ultrasonic coupling dielectric material: the mass percent of propyl acrylate is 60%, make the linking agent N of propyl acrylate crosslinking reaction, the mass percent of N '-methylene bisacrylamide propyl propionate is 0.3%, the reductive agent Sodium Metabisulfite of initiation reaction and the total mass percent of potassium metabisulfite are 0.1% (wherein, the mass ratio of Sodium Metabisulfite and potassium metabisulfite is 1:2), the oxygenant ammonium persulphate of initiation reaction and the total mass per-cent of Potassium Persulphate are 0.15% (wherein, the mass ratio of ammonium persulphate and Potassium Persulphate is 1:1), the mass percent of organic solvent glycerol is 30%, the mass percent of water is 9.45%.
The present embodiment provides a kind of preparation method of above-mentioned treatment ultrasonic coupling dielectric material, comprises the following steps:
(1) propyl acrylate is dissolved in organic solvent glycerol, add the linking agent N making propyl acrylate crosslinking reaction again, N '-methylene bisacrylamide propyl propionate, then degassed process is carried out, wherein, the vacuum tightness of degassed process is-0.09Mpa, and the time of degassed process is 20 minutes ~ 2 hours;
(2) by the reductive agent Sodium Metabisulfite of initiation reaction and potassium metabisulfite, with the oxygenant ammonium persulphate of initiation reaction and Potassium Persulphate soluble in water, then carry out degassed process, wherein, the vacuum tightness of degassed process is-0.09Mpa, and the time of degassed process is 20 minutes ~ 2 hours;
(3) step (1) and step (2) are obtained solution mixing, obtain medical treatment and use ultrasonic coupling dielectric material.
30 DEG C time, when the ultrasonic wave of focusing ultrasonic therapeutic apparatus is propagated in this treatment ultrasonic coupling dielectric material, the velocity of sound is 1580m/s, and specific acoustic impedance is 1.2 × 10
6pas/m, acoustic attenuation coefficient is 0.05dB/cmMHz.This treatment ultrasonic coupling dielectric material reaches the national standard of medical ultrasonic coupling agent.
Embodiment 6
The present embodiment provides a kind of and treats consisting of of the composition of raw materials prepared with ultrasonic coupling dielectric material: the mass percent of amyl acrylate is 9.84%, make the linking agent N of amyl acrylate crosslinking reaction, the mass percent of N '-methylene bisacrylamide acid pentyl ester is 0.06%, the reductive agent Sodium Metabisulfite of initiation reaction and the total mass per-cent of Potassium hydrogen sulfite are 0.05% (wherein, the mass percent of Sodium Metabisulfite and Potassium hydrogen sulfite is 2:1), the mass percent of the oxygenant Potassium Persulphate of initiation reaction is 0.05%, the mass percent of organic solvent ethylene glycol is 65%, the mass percent of water is 25%.
The present embodiment provides a kind of preparation method of above-mentioned treatment ultrasonic coupling dielectric material, comprises the following steps:
(1) amyl acrylate is dissolved in organic solvent ethylene glycol, add the linking agent N making amyl acrylate crosslinking reaction again, N '-methylene bisacrylamide acid pentyl ester, then degassed process is carried out, wherein, the vacuum tightness of degassed process is-0.092Mpa, and the time of degassed process is 20 minutes ~ 2 hours;
(2) by the reductive agent Sodium Metabisulfite of initiation reaction and the oxygenant Potassium Persulphate of Potassium hydrogen sulfite and initiation reaction soluble in water, then degassed process is carried out, wherein, the vacuum tightness of degassed process is-0.092Mpa, and the time of degassed process is 20 minutes ~ 2 hours;
(3) step (1) and step (2) are obtained solution mixing, obtain medical treatment and use ultrasonic coupling dielectric material.
40 DEG C time, when the ultrasonic wave of focusing ultrasonic therapeutic apparatus is propagated in this treatment ultrasonic coupling dielectric material, the velocity of sound is 1500m/s, and specific acoustic impedance is 1.5 × 10
6pas/m, acoustic attenuation coefficient is 0 ~ 0.05dB/cmMHz.This treatment ultrasonic coupling dielectric material reaches the national standard of medical ultrasonic coupling agent.
Be understandable that, the illustrative embodiments that above embodiment is only used to principle of the present invention is described and adopts, but the present invention is not limited thereto.For those skilled in the art, without departing from the spirit and substance in the present invention, can make various modification and improvement, these modification and improvement are also considered as protection scope of the present invention.
Claims (12)
1. ultrasonic coupling dielectric material is used in a treatment, it is characterized in that, its composition of raw materials prepared comprises: the reductive agent of monomer, linking agent, initiation reaction, the oxygenant of initiation reaction, organic solvent and water, wherein, described monomer is any one in Methacrylamide, methacrylic acid, acrylamide, vinylformic acid, acrylate derivative.
2. treatment ultrasonic coupling dielectric material according to claim 1, it is characterized in that, the composition of its composition of raw materials prepared comprises: the mass percent of described monomer is 5 ~ 60%, the mass percent of described linking agent is 0.03 ~ 0.3%, the mass percent of the reductive agent of described initiation reaction is 0.02 ~ 0.1%, the mass percent of the oxygenant of described initiation reaction is 0.03 ~ 0.15%, the mass percent of described organic solvent is 30 ~ 90%, and the mass percent of described water is 3 ~ 25%.
3. treatment ultrasonic coupling dielectric material according to claim 1 and 2, is characterized in that, described acrylate derivative is any one in methyl acrylate, ethyl propenoate, propyl acrylate, butyl acrylate, amyl acrylate.
4. treatment ultrasonic coupling dielectric material according to claim 1 and 2, is characterized in that, described organic solvent is ethylene glycol or glycerol.
5. treatment ultrasonic coupling dielectric material according to claim 1 and 2, is characterized in that, described linking agent is N, N '-methylene-bisacrylamide.
6. treatment ultrasonic coupling dielectric material according to claim 1 and 2, is characterized in that, the reductive agent of described initiation reaction is for laying particular stress on sulphite and/or sulphite.
7. treatment ultrasonic coupling dielectric material according to claim 6, is characterized in that, described in lay particular stress on sulphite be Sodium Metabisulfite and/or potassium metabisulfite, described sulphite is sodium bisulfite and/or Potassium hydrogen sulfite.
8. treatment ultrasonic coupling dielectric material according to claim 1 and 2, is characterized in that, the oxygenant of described initiation reaction is persulphate and/or benzoyl peroxide.
9. treatment ultrasonic coupling dielectric material according to claim 8, is characterized in that, described persulphate is ammonium persulphate and/or Potassium Persulphate.
10. treatment ultrasonic coupling dielectric material according to claim 1 and 2, it is characterized in that, 20 ~ 40 DEG C time, when the ultrasonic wave of focusing ultrasonic therapeutic apparatus is propagated in this treatment ultrasonic coupling dielectric material, the velocity of sound is 1480 ~ 1680m/s, and specific acoustic impedance is 1.2 × 10
6~ 2.0 × 10
6pas/m, acoustic attenuation coefficient is 0.05 ~ 1.0dB/cmMHz.
11. 1 kinds of preparation methods treated with ultrasonic coupling dielectric material, is characterized in that, comprise the following steps:
(1) monomer is dissolved in organic solvent, add the linking agent making described monomer crosslinked reaction again, carry out degassed process until completely dissolved, wherein, described monomer is any one in Methacrylamide, methacrylic acid, acrylamide, vinylformic acid, acrylate derivative;
(2) by the reductive agent of initiation reaction and the oxygenant of initiation reaction soluble in water, then carry out degassed process;
(3) the solution mixing described step (1) and described step (2) obtained, obtains the polymer gel being used as treatment ultrasonic coupling dielectric material.
The preparation method of 12. treatment ultrasonic coupling dielectric materials according to claim 11, is characterized in that,
The vacuum tightness of the degassed process in described step (1) is-0.095 ~-0.08Mpa;
The vacuum tightness of the degassed process in described step (2) is-0.095 ~-0.08Mpa.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106632904A (en) * | 2016-12-19 | 2017-05-10 | 钦州市钦南区科学技术情报研究所 | Ultrasonic coupling medium material and preparation method thereof |
| CN108187075A (en) * | 2018-03-29 | 2018-06-22 | 江西乐迪医疗科技有限公司 | A kind of medical supersonic coupled patch preparation method |
| CN109793902A (en) * | 2019-03-26 | 2019-05-24 | 中国人民大学 | A kind of solid gel piece and the preparation method and application thereof |
| CN113574108A (en) * | 2019-02-13 | 2021-10-29 | 决策科学医疗有限责任公司 | Hydrogel compositions for semi-rigid acoustic coupling media in ultrasound imaging |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803196A (en) * | 2005-01-10 | 2006-07-19 | 重庆海扶(Hifu)技术有限公司 | Fluorocarbonemulsion analog assistant for high-intensity focusing ultrasonic therapy and its uses |
| CN101024676A (en) * | 2007-02-09 | 2007-08-29 | 上海大学 | Preparation for smart water gel responding microwave |
| CN101513554A (en) * | 2008-02-21 | 2009-08-26 | 重庆海扶(Hifu)技术有限公司 | Intelligent type tissue-mimicking ultrasonic phantom and preparation method thereof |
| CN103524758A (en) * | 2013-09-18 | 2014-01-22 | 深圳市普罗惠仁医学科技有限公司 | Fabrication technology of gel polymerization stock solution, intelligent bionic body model and fabrication technology thereof |
-
2014
- 2014-07-03 CN CN201410315918.5A patent/CN105330786B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803196A (en) * | 2005-01-10 | 2006-07-19 | 重庆海扶(Hifu)技术有限公司 | Fluorocarbonemulsion analog assistant for high-intensity focusing ultrasonic therapy and its uses |
| CN101024676A (en) * | 2007-02-09 | 2007-08-29 | 上海大学 | Preparation for smart water gel responding microwave |
| CN101513554A (en) * | 2008-02-21 | 2009-08-26 | 重庆海扶(Hifu)技术有限公司 | Intelligent type tissue-mimicking ultrasonic phantom and preparation method thereof |
| CN103524758A (en) * | 2013-09-18 | 2014-01-22 | 深圳市普罗惠仁医学科技有限公司 | Fabrication technology of gel polymerization stock solution, intelligent bionic body model and fabrication technology thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106632904A (en) * | 2016-12-19 | 2017-05-10 | 钦州市钦南区科学技术情报研究所 | Ultrasonic coupling medium material and preparation method thereof |
| CN108187075A (en) * | 2018-03-29 | 2018-06-22 | 江西乐迪医疗科技有限公司 | A kind of medical supersonic coupled patch preparation method |
| CN113574108A (en) * | 2019-02-13 | 2021-10-29 | 决策科学医疗有限责任公司 | Hydrogel compositions for semi-rigid acoustic coupling media in ultrasound imaging |
| CN109793902A (en) * | 2019-03-26 | 2019-05-24 | 中国人民大学 | A kind of solid gel piece and the preparation method and application thereof |
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