CN108187183B - Built-in medical ultrasonic thrombolysis therapeutic apparatus - Google Patents

Built-in medical ultrasonic thrombolysis therapeutic apparatus Download PDF

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CN108187183B
CN108187183B CN201711405495.6A CN201711405495A CN108187183B CN 108187183 B CN108187183 B CN 108187183B CN 201711405495 A CN201711405495 A CN 201711405495A CN 108187183 B CN108187183 B CN 108187183B
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ultrasonic
blood vessel
indwelling
waveguide tube
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CN108187183A (en
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刘细宝
汪跃群
郁涛
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715th Research Institute of CSIC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B17/2202—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16886—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body for measuring fluid flow rate, i.e. flowmeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/44—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22038—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22088—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance ultrasound absorbing, drug activated by ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3368—Temperature

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Abstract

The invention relates to the technical field of medical instruments, in particular to a built-in medical ultrasonic thrombolysis therapeutic apparatus which comprises an infusion apparatus, an ultrasonic loading module and an ultrasonic indwelling waveguide tube. The front cover plate and the amplitude transformer of the ultrasonic transducer in the ultrasonic loading module are both made of TC4 titanium alloy materials, and a through hole with the diameter phi of 1mm is punched in the middle of the front cover plate and the amplitude transformer. The ultrasonic indwelling waveguide enters the blood vessel along the blood flow direction from the upstream of the blood vessel with thrombus. A plurality of small holes are dug on two sides of the part of the ultrasonic indwelling waveguide tube entering the blood vessel, so that ultrasonic waves are directly transmitted in the blood vessel with emboli, and then the thrombus is ablated by matching with a thrombolytic agent. The experimental verification proves that the medicine has the advantages of non-invasive property for treating the thrombotic diseases, simple and convenient operation and repeated use. The ultrasonic energy only plays a role in the internal part, the ultrasonic effect and the medicine directly reach the focus, the thrombolysis effect is good, meanwhile, the injury to the surrounding tissues is small, and the ultrasonic thrombolytic drug is safe, has no side effect, has no adverse reaction and the like and has great advantages.

Description

Built-in medical ultrasonic thrombolysis therapeutic apparatus
Technical Field
The invention relates to the technical field of medical instruments, in particular to a built-in medical ultrasonic thrombolysis therapeutic apparatus.
Background
According to reliable statistics, about 3.3 hundred million hypertension patients in China account for about 23.6 percent of the total population, the population is larger than that of the whole American, and the proportion is further increased along with the aging. At the well-known yaerta conference, the world patterns were reconstructed by the three macrostomas rossfort, swalin and cugill, however, they all succumbed to cardiovascular and cerebrovascular-induced diseases, respectively. Hypertension is the condition in which the lateral pressure on the vessel wall is higher than normal when the blood is narrowed and blocked and flows smoothly. Hypertension is caused by the target injury of organs such as heart, brain, kidney, eye, etc., which is called target organ injury. In short, there is a possibility that the attack may be made wherever there is an artery. After the atherosclerotic plaque is accumulated to a certain degree, the atherosclerotic plaque is easily impacted by blood flow, and the plaque is broken and separated from a blood vessel to form emboli and block the blood vessel. Coronary heart disease if it occurs in the coronary arteries supplying the heart vessels; if the cerebral thrombus happens, cerebral thrombus and cerebral apoplexy are caused.
In addition, hemodialysis is one of the main renal replacement therapies for patients with renal failure, and establishing an effective vascular access is a prerequisite for smooth hemodialysis, and the vascular access is called the life line of uremia patients. Good vascular access requires blood flow of 200-. Thus, thrombus is a major cause of vascular access failure.
Therefore, it is important to eliminate thrombus, reduce blood pressure and restore blood vessel patency. At present, the artificial mechanical methods comprise balloon catheter operation and surgical embolectomy, but complications such as heavy bleeding and the like are easily caused, the operation risk is high, the cost is high, and repeated attack is easy to happen. Therefore, clinically, the drugs for promoting blood circulation and removing blood stasis, such as safflower, salvia miltiorrhiza, angelica, panax notoginseng, leech, aspirin, or tissue plasminogen activator, prourokinase (Pro-UK), etc., are often used orally or as drops. But either only preventive, or slow acting, long thrombolysis time (often a week).
New sonothrombolysis has then emerged on the market. The energy of ultrasonic wave such as mechanical vibration, cavitation effect, micro-current shearing force, micro-beam current and the like is mainly utilized, and then the pharmacological action of the thrombolytic agent is matched to break and dissolve the thrombus and embolize the blood vessel for recanalization. An External Therapeutic Ultrasonic (ETUS) with high frequency and low energy, such as "thrombolytic therapy probe" with patent number "CN 203898961U" applied by Shenzhen Wilde medical electronics Limited company, is characterized in that the probe is externally arranged at the position of an occlusion blood vessel, and the ultrasonic wave emitted by the probe passes through a coupling agent and the skin blood vessel to treat embolus. When the power is higher, the skin of a patient has obvious burning discomfort; the thrombolytic effect is not ideal when the power is low. There is also a system for promoting extracorporeal ultrasound ablation of thrombi, such as microbubble acoustic contrast agent, for example, the invention patent number "CN 205548629U" applied to Guangzhou general Hospital in Guangzhou military area, which is named as "an ultrasound microbubble cavitation thrombolysis system", which is to transmit ultrasound waves in vitro on the one hand and to inject ultrasound waves exciting contrast agent and thrombolysis agent in blood vessels on the other hand. This is an internal and external combination, which does promote the ablation of thrombus and improves the effect, but the patient still feels hot and uncomfortable and does not exert the performance advantage of ultrasonic waves to the maximum extent.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides a built-in medical ultrasonic thrombolysis therapeutic apparatus.
The purpose of the invention is achieved by the following technical scheme: the built-in medical ultrasonic thrombolysis therapeutic apparatus mainly comprises an infusion apparatus, an ultrasonic loading module and an ultrasonic indwelling waveguide tube. The infusion pump is internally filled with physiological saline or thrombolytic agents, the infusion pump is connected with the exhaust chamber, the exhaust chamber is connected with the dripping speed sensor, the dripping speed sensor is connected with the heater, the heater is connected with the ultrasonic transducer, the ultrasonic transducer is driven by the ultrasonic generator, the ultrasonic transducer is connected with the ultrasonic indwelling waveguide tube through the hose clamp, the ultrasonic indwelling waveguide tube enters the blood vessel along the blood flow direction at the upstream of the blood vessel with thrombus, and a plurality of small holes are dug at two sides of the part of the ultrasonic indwelling waveguide tube entering the blood vessel.
The infusion apparatus comprises an infusion pump, an exhaust chamber, a dripping speed sensor and a heater, as shown in figure 1.
The ultrasonic loading module comprises a driving power supply with adjustable power and an ultrasonic transducer.
The ultrasonic transducer comprises an ultrasonic vibrator and a horn. The front cover plate and the amplitude transformer of the ultrasonic vibrator are made of TC4 titanium alloy, the piezoelectric ceramic element of the ultrasonic vibrator is made of P4 medium-power emitting material, and the acoustic impedance Z of the TC4 titanium alloy4＝2.71X107pa s/m and acoustic impedance Z of piezoelectric ceramic P45＝3X107pa s/m are close, see in particular the material properties of table 1 below.
TABLE 1 Material Properties
Material Seawater Z1 Polyurethane Z2 Blood Z3 TC4 titanium alloy Z4 Piezoelectric ceramic Z5
Speed of sound (m/s) 1500 1520 1570 6100 4000
Density (kg/m)3) 1026 1031 1054 4450 7500
Acoustic impedance (pa s/m) 1.54X106 1.57X106 1.65X106 2.71X107 3X107
The first scheme of the ultrasonic transducer is shown in fig. 2, the total length is 58.5mm, the maximum diameter of the skirt is phi 25mm, the resonance frequency fs is 69.8kHz, the performance test curve is shown in fig. 3, and a through hole with the diameter phi 2mm is drilled in the whole middle. The experimental result shows that the power is smaller and the thrombolysis effect is not ideal.
As a second optimized scheme, as shown in FIG. 4, the total length is 178.5mm, the maximum diameter of the chuck is phi 25mm, and only the L-shaped hole with the length of 95mm and the diameter of phi 1.5mm is knocked down on the amplitude transformer. The experimental result shows that the power is improved, but the thrombolysis effect is still not ideal.
As a third optimized scheme, as shown in FIG. 5, the total length is 204mm, the maximum diameter of the chuck is still phi 25mm, and a through hole with the diameter of phi 1mm is drilled in the middle of the whole transducer, so that the medicament can conveniently flow through and load ultrasonic energy, and meanwhile, the processing level is comprehensively considered. The above structure was simulated using finite element analysis software Ansys. Firstly, a finite element simulation model is established, as shown in fig. 6, an equivalent stress cloud graph when the transducer vibrates is shown in fig. 7, and the simulated resonance frequency fs is 54 kHz. The actual performance test curve is shown in fig. 8, and the resonance frequency fs is 56kHz, which is a normal error of the material parameter setting. The experimental result shows that the transducer in the scheme has strong output power, large amplitude and excellent effect, so that the scheme III is finally selected as the final scheme of the invention.
The ultrasonic indwelling waveguide tube is made of polyurethane material. The infusion is physiological saline added with thrombolytic agent, the specific property is slightly different with the addition of different thrombolytic agents, so that the infusion is simulated by seawater reference, namely about Z1＝1.54X106pa s/m. And acoustic impedance Z of blood3＝1.65X106pa s/m, acoustic impedance of polyurethane Z2＝1.57X106pa s/m, which are almost identical, and Z2Is exactly Z1And Z3In the meantime. The two transmission losses of sound waves from the drop incident on the blood through the polyurethane waveguide and tl (db) are given by the fact that plane waves are incident perpendicularly on two different homogeneous medium surfaces:
Figure BDA0001520223480000021
table 1 the data is substituted for formula 1, with very small and negligible transmission losses and TL. Therefore, the ultrasonic indwelling waveguide tube is made of polyurethane.
In order to radiate sound waves and thrombolytic agents to blood and enhance the ultrasonic thrombolytic effect, the two sides of the ultrasonic catheter are respectively dug with openings, as shown in fig. 9, the distance between two adjacent openings on the same side is
Figure BDA0001520223480000031
And the position of the hole on one side is just in the middle of the two holes on the other side, namely the position is
Figure BDA0001520223480000032
The invention has the beneficial effects that:
1. the infusion pump has a semi-extrusion function and a pulsation compensation technology, so that the infusion is more uniform, the error is small, and the elasticity and the flow rate precision of the pipeline can be kept for a long time.
2. The heater can heat the flowing liquid to 40-50 ℃ and can be adjusted according to the ambient temperature in summer and winter and the personal feeling of the patient.
3. The invention has the advantages of non-invasive, simple and convenient operation, repeated use, ultrasonic energy only playing a role in the inner part, ultrasonic effect and medicine directly reaching the focus, good thrombolysis effect, short treatment time, small damage to surrounding tissues, safety, reliability and the like.
Drawings
Fig. 1 is a schematic structural diagram of the ultrasonic thrombolysis therapeutic apparatus of the present invention.
Fig. 2 is a diagram of an ultrasound transducer arrangement of the present invention.
Fig. 3 is a graph of impedance testing for the first ultrasonic transducer embodiment of the present invention.
Fig. 4 is a diagram of a second embodiment of the ultrasonic transducer of the present invention.
Fig. 5 is a third diagram of an ultrasound transducer arrangement of the present invention.
Fig. 6 is a simulation model diagram of a third ultrasonic transducer scheme of the present invention.
Fig. 7 is an equivalent stress cloud diagram of a third ultrasound transducer embodiment of the present invention.
Fig. 8 is a graph of impedance testing for the third ultrasonic transducer embodiment of the present invention.
FIG. 9 is a diagram showing the pitch of ultrasonic indwelling waveguides in accordance with the present invention.
Description of reference numerals: the device comprises an infusion pump 1, a normal saline or thrombolytic agent 2, an exhaust chamber 3, a dropping speed sensor 4, a heater 5, an ultrasonic transducer 6, an ultrasonic generator 7, a hose clamp 8, an ultrasonic indwelling waveguide 9, a thrombus 10, a blood vessel 11, a hole 12, an ultrasonic vibrator 13, an amplitude transformer 14, a front cover plate 15 and a through hole 16.
Detailed Description
The invention will be described in detail below with reference to the following drawings:
as shown in the attached drawing, the built-in medical ultrasonic thrombolysis therapeutic apparatus mainly comprises an infusion pump 1, wherein the infusion pump 1 is filled with physiological saline or thrombolysis agent 2. The infusion pump 1 is connected with an exhaust chamber 3, the exhaust chamber 3 is connected with a dripping speed sensor 4, the dripping speed sensor 4 is connected with a heater 5, the heater 5 is connected with an ultrasonic transducer 6, and the ultrasonic transducer 6 is driven by an ultrasonic generator 7. The ultrasonic transducer 6 is connected with an ultrasonic wave indwelling waveguide tube 9 through a hose clamp 8. The hose clamp 8 can ensure that the ultrasonic transducer 6 and the ultrasonic wave indwelling waveguide tube 9 are not easy to fall off when vibrating. The ultrasonic indwelling waveguide 9 enters the blood vessel 11 in the blood flow direction at the upstream of the blood vessel 11 having the thrombus 10. A plurality of small holes 12 are dug on two sides of the part of the ultrasonic indwelling waveguide tube 9 entering the blood vessel 11.
In practice, the heater 5 can heat the flowing liquid to 40-50 ℃ and can be adjusted according to the ambient temperature in summer and winter and the personal feeling of the patient.
As shown in fig. 5, the ultrasonic transducer 6 includes an ultrasonic vibrator 13 and a horn 14, the ultrasonic vibrator 13 includes, but is not limited to, a front cover plate 15, and the front cover plate 15 and the horn 14 are both made of TC4 titanium alloy material. A through hole 16 with the diameter phi of 1mm is arranged between the ultrasonic vibrator 13 and the amplitude transformer 14. The total length of the ultrasonic transducer 6 is 204mm, and the resonance frequency fs is 56 kHz.
As shown in fig. 9, the ultrasonic standing waveguide 9 is made of polyurethane. A plurality of small holes 12 are dug on two sides of the ultrasonic wave indwelling waveguide tube 9, and the distance between two adjacent holes on the same side is 26.8 mm. And the hole position of one side is just in the middle of two hole positions of the other side, namely the distance between two adjacent holes on the opposite side is 13.4 mm.
It should be understood that equivalent substitutions and changes to the technical solution and the inventive concept of the present invention should be made by those skilled in the art to the protection scope of the appended claims.

Claims (2)

1. A built-in medical ultrasonic thrombolysis therapeutic apparatus is characterized in that: the infusion pump mainly comprises an infusion pump (1), wherein physiological saline or thrombolytic agents (2) are contained in the infusion pump (1), the infusion pump (1) is connected with an exhaust chamber (3), the exhaust chamber (3) is connected with a dripping speed sensor (4), the dripping speed sensor (4) is connected with a heater (5), the heater (5) is connected with an ultrasonic transducer (6), the ultrasonic transducer (6) is driven by an ultrasonic generator (7), the ultrasonic transducer (6) is connected with an ultrasonic indwelling waveguide tube (9) through a hose clamp (8), the ultrasonic indwelling waveguide tube (9) enters the blood vessel (11) at the upstream of the blood vessel (11) with thrombus (10) along the blood flow direction, a plurality of small holes (12) are dug at two sides of the part of the ultrasonic indwelling waveguide tube (9) entering the blood vessel (11), and the hole position at one side is just in the middle of the two hole positions;
the ultrasonic transducer (6) comprises an ultrasonic vibrator (13) and an amplitude transformer (14), the ultrasonic vibrator (13) comprises but is not limited to a front cover plate (15), and the front cover plate (15) and the amplitude transformer (14) are both made of TC4 titanium alloy materials; a through hole (16) is formed between the ultrasonic vibrator (13) and the amplitude transformer (14), and the resonant frequency is fs =56 kHz.
2. The built-in medical ultrasonic thrombolysis therapeutic apparatus according to claim 1, wherein: the heater (5) can heat the flowing liquid to 40-50 ℃ and can be adjusted.
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CN109374752A (en) * 2018-11-20 2019-02-22 中国航发贵州黎阳航空动力有限公司 A kind of ultrasonic probe apparatus
US20210030432A1 (en) * 2019-07-30 2021-02-04 National Tsing Hua University Vortex catheter thrombolytic system and thrombolytic method thereof
CN111772730A (en) * 2020-06-22 2020-10-16 合肥市第二人民医院 Thrombolytic drainage device
CN113974765B (en) * 2021-10-22 2022-09-06 北京荷清和创医疗科技有限公司 Intervention type thrombus removal device and thrombolysis promoting module

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EP0251512B1 (en) * 1986-06-09 1994-08-31 The Regents Of The University Of California Apparatus for removing gallstones
CN1216910A (en) * 1996-04-24 1999-05-19 加利福尼亚大学董事会 Opto-acoustic thrombolysis
CN201959333U (en) * 2011-02-25 2011-09-07 陈兰 Novel device for thrombolysis treatment of arteriovenous internal fistula
CN204523385U (en) * 2014-12-26 2015-08-05 中国船舶重工集团公司第七一五研究所 A kind of ultrasonic atomization transducer
CN205548629U (en) * 2016-03-24 2016-09-07 广州军区广州总医院 Bolt system is dissolved to supersound microbubble cavitation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0251512B1 (en) * 1986-06-09 1994-08-31 The Regents Of The University Of California Apparatus for removing gallstones
CN1216910A (en) * 1996-04-24 1999-05-19 加利福尼亚大学董事会 Opto-acoustic thrombolysis
CN201959333U (en) * 2011-02-25 2011-09-07 陈兰 Novel device for thrombolysis treatment of arteriovenous internal fistula
CN204523385U (en) * 2014-12-26 2015-08-05 中国船舶重工集团公司第七一五研究所 A kind of ultrasonic atomization transducer
CN205548629U (en) * 2016-03-24 2016-09-07 广州军区广州总医院 Bolt system is dissolved to supersound microbubble cavitation

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