CN108187040B - 一种疫苗佐剂及其制备方法 - Google Patents
一种疫苗佐剂及其制备方法 Download PDFInfo
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- CN108187040B CN108187040B CN201810023586.1A CN201810023586A CN108187040B CN 108187040 B CN108187040 B CN 108187040B CN 201810023586 A CN201810023586 A CN 201810023586A CN 108187040 B CN108187040 B CN 108187040B
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- adjuvant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
实施例1 | 实施例2 | 实施例3 | 实施例4 | 实施例5 | 实施例6 | 实施例7 | |
注射用水 | 60 | 80 | 100 | 70 | 80 | 90 | 75 |
脂质体 | 6 | 5 | 3 | 5 | 4 | 3 | 5 |
木鳖子皂苷 | 0 | 0 | 0 | 6 | 5 | 3 | 5 |
吐温-80 | 8 | 6 | 4 | 7 | 6 | 5 | 6 |
注射用白油 | 100 | 80 | 60 | 80 | 70 | 90 | 75 |
雷西莫特 | 8 | 6 | 5 | 7 | 6 | 5 | 8 |
硬脂酸铝 | 0 | 0 | 0 | 0 | 0 | 0 | 15 |
司盘-80 | 8 | 6 | 4 | 7 | 6 | 5 | 6 |
终点滴度 | 1:526410 | 1:519880 | 1:523120 | 1:794280 | 1:790320 | 1:788140 | 1:984150 |
实施例8 | 实施例9 | 对比例1 | 对比例2 | 对比例3 | 对比例4 | 对比例5 | 对比例6 | |
注射用水 | 80 | 85 | 75 | 80 | 85 | 75 | 80 | 85 |
脂质体 | 5 | 4 | 6 | 5 | 4 | 0 | 0 | 0 |
木鳖子皂苷 | 5 | 4 | 6 | 5 | 5 | 6 | 5 | 4 |
吐温-80 | 6 | 6 | 6 | 5 | 7 | 7 | 5 | 6 |
注射用白油 | 80 | 85 | 85 | 75 | 80 | 85 | 75 | 80 |
雷西莫特 | 6 | 5 | 0 | 0 | 0 | 4 | 6 | 5 |
硬脂酸铝 | 20 | 30 | 18 | 20 | 25 | 15 | 20 | 28 |
司盘-80 | 80 | 85 | 7 | 6 | 5 | 7 | 6 | 6 |
终点滴度 | 1:984500 | 1:985320 | 1:701670 | 1:712760 | 1:699730 | 1:613920 | 1:620910 | 1:613640 |
Claims (5)
Priority Applications (1)
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CN201810023586.1A CN108187040B (zh) | 2018-01-10 | 2018-01-10 | 一种疫苗佐剂及其制备方法 |
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CN201810023586.1A CN108187040B (zh) | 2018-01-10 | 2018-01-10 | 一种疫苗佐剂及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN108187040A CN108187040A (zh) | 2018-06-22 |
CN108187040B true CN108187040B (zh) | 2021-11-09 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111658611B (zh) * | 2020-04-13 | 2021-06-01 | 四川大学 | 一种基于微乳的疫苗递送系统及其制备方法和应用 |
CN111888469A (zh) * | 2020-09-11 | 2020-11-06 | 苏州瑞微生物科技有限公司 | 一种IgY脂质体喷雾及其制备方法 |
WO2022143894A1 (zh) * | 2020-12-30 | 2022-07-07 | 苏州百迈生物医药有限公司 | 一种自缓释免疫佐剂混悬液及其制备方法和应用 |
CN113230396A (zh) * | 2021-05-25 | 2021-08-10 | 唐水泉 | 一种混合型疫苗佐剂,及其生产方法 |
CN115181117B (zh) * | 2022-08-08 | 2024-05-17 | 中国医学科学院医学生物学研究所 | 一种s构型手性分子化合物及其制备方法和作为疫苗佐剂的应用 |
Citations (5)
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---|---|---|---|---|
CN1748792A (zh) * | 2005-08-19 | 2006-03-22 | 浙江大学 | 木鳖子含三萜皂甙提取物的用途 |
CN101152571A (zh) * | 2007-10-09 | 2008-04-02 | 浙江大学 | 一种含木鳖子皂甙的油佐剂疫苗及其制备方法 |
CN101428145A (zh) * | 2007-11-05 | 2009-05-13 | 北京生泰尔生物科技有限公司 | 新型疫苗佐剂 |
CN102743750A (zh) * | 2012-07-09 | 2012-10-24 | 江苏省农业科学院 | 一种复方免疫增强剂、禽用疫苗及其制备方法 |
CN105732807A (zh) * | 2016-02-24 | 2016-07-06 | 福州大北农生物技术有限公司 | 一种猪伪狂犬病病毒阳性血清的制备方法 |
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- 2018-01-10 CN CN201810023586.1A patent/CN108187040B/zh active Active
Patent Citations (5)
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CN1748792A (zh) * | 2005-08-19 | 2006-03-22 | 浙江大学 | 木鳖子含三萜皂甙提取物的用途 |
CN101152571A (zh) * | 2007-10-09 | 2008-04-02 | 浙江大学 | 一种含木鳖子皂甙的油佐剂疫苗及其制备方法 |
CN101428145A (zh) * | 2007-11-05 | 2009-05-13 | 北京生泰尔生物科技有限公司 | 新型疫苗佐剂 |
CN102743750A (zh) * | 2012-07-09 | 2012-10-24 | 江苏省农业科学院 | 一种复方免疫增强剂、禽用疫苗及其制备方法 |
CN105732807A (zh) * | 2016-02-24 | 2016-07-06 | 福州大北农生物技术有限公司 | 一种猪伪狂犬病病毒阳性血清的制备方法 |
Non-Patent Citations (3)
Title |
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Resiquimod and polyinosinic–polycytidylic acid formulation with aluminum hydroxide as an adjuvant for foot-and-mouth disease vaccine;ZHOU C.X., et al.;《BMC Veterinary Research》;20140103;第2篇第1-7页 * |
沈沅 等.瑞喹莫德( R848) 具有更强的免疫佐剂效应.《细胞与分子免疫学杂志》.2017,第591页摘要、右栏第1段. * |
瑞喹莫德( R848) 具有更强的免疫佐剂效应;沈沅 等;《细胞与分子免疫学杂志》;20171231;第591页摘要、右栏第1段 * |
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CN108187040A (zh) | 2018-06-22 |
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