CN108186918A - A kind of Chinese medicine composition for treating chronic glomerulonephritis and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating chronic glomerulonephritis and preparation method thereof Download PDFInfo
- Publication number
- CN108186918A CN108186918A CN201810088730.XA CN201810088730A CN108186918A CN 108186918 A CN108186918 A CN 108186918A CN 201810088730 A CN201810088730 A CN 201810088730A CN 108186918 A CN108186918 A CN 108186918A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- chronic glomerulonephritis
- medicine composition
- ethyl alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The present invention relates to a kind of Chinese medicine composition for treating chronic glomerulonephritis and preparation method thereof, the Chinese medicine composition is prepared by following bulk pharmaceutical chemicals：Prepared rehmannia root, Chinese yam, matrimony vine, dogwood fruit, Semen Cuscutae, tortoise-shell glue, deer horn glue, umbellate pore furgus, Poria cocos, radix bupleuri, Rhizoma Atractylodis Macrocephalae, cassia twig, cicada slough, windproof, rhizoma imperatae, radix achyranthis bidentatae.The Chinese medicine composition reasonable recipe of present invention treatment chronic glomerulonephritis, the effect of can reach kidney tonifying both YIN and YANG, kidney tonifying effect consolidates persistently, by kidney and spleen invigorating kidney essense abundance, spleen fortune is strong, albumen and blood Hang Yuchang roads, while the nephrons loss of fundamentally treatment chronic glomerulonephritis, the symptoms such as albuminuria, blood urine, hypertension, treating both manifestation and root cause of disease, suitable for the treatment of various chronic glomerulonephritis patients can also effectively be alleviated.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating chronic glomerulonephritis and its preparation
Method.
Background technology
Chronic glomerulonephritis, abbreviation chronic nephritis are one group of long courses of disease caused by various primary glomerulopathies,
Disease with albuminuria, blood urine, oedema, hypertension etc. for clinical manifestation.The treatment of chronic glomerulonephritis is more difficult, prognosis
Difference, along with the progress of the state of an illness, patient there is also the serious complication such as anaemia, uremia, retinopathy, and chronic renal
Bead ephritis majority can develop into chronic renal failure.
For chronic glomerulonephritis, doctor trained in Western medicine is generally using symptomatic treatment at present, in addition to sodium and protein in dietary restriction
Intake, reduce blood pressure it is outer, generally by taking the deterioration of glucocorticoid and the immunosuppressive agent delays state of an illness, although achieving
Certain symptomatic treatment effect, but often exist and induce, even aggravate infection, lead to peptic ulcer, osteoporosis, aseptic
Therefore the adverse reactions such as caput femoris necrosis, tend not to obtain ideal curative effect.
Chronic glomerulonephritis, which is generally acknowledged that, belongs in the traditional Chinese medical science scopes such as " oedema ", " pain in the back ", " blood urine ", " stranguria ", because
This, for chronic glomerulonephritis, there are the different therapies such as strengthening spleen, tonifying kidney, clearing heat and promoting diuresis, promoting blood circulation and removing obstruction in channels, and achieves certain
Curative effect, such as Bai Zhengxue reports, comprising Chinese yam, Radix Astragali, the fruit of glossy privet, pyrrosia lingua, cicada slough, Fructus Forsythiae, leech Ning Shuitang can be notable
Improve the treatments such as chronic glomerulonephritis patients albuminuria, blood urine, renal function, can effective delaying chronic glomerulus ephritis disease
Reason process.Some scholars propose that the chronic glomerulonephritis state of an illness is slowly in progress, treats difficulty, the characteristic of poor prognosis belongs to the traditional Chinese medical science
" kidney wind " scope, nephrons virtual loss, ailment said due to cold or exposure invasion human body in following through entering, injure kidney and send out as kidney wind.Ailment said due to cold or exposure, which has, to lightly float, rises
It dissipates, characteristic up and out, it is general easily to invade the positive position such as throat, back, when ailment said due to cold or exposure visitor is in kidney, kidney not store essential substances, vital essence can be caused
Under let out and form albuminuria, and ailment said due to cold or exposure penetrates kidney film, blood network, and film network is caused to be damaged, then can be led to that blood leaks, and forms blood
Urine, and wind being primary pathogen, cold, hot, wet, malicious etc. can all depend on ailment said due to cold or exposure and invade human body, so as to undermine kidney, early stage shows
For chill, rheumatism, wind-heat, damp and hot etc., later stage visible wet turbid, hemostasis etc..It, must for kidney wind since the cause of disease of kidney wind is in wind
With expelling wind drug, such as Chinese ephedra, windproof, Stephania tetrandra, cicada slough, duckweed, caulis sinomenii, tripterygium wilfordii.Since ailment said due to cold or exposure is normal and folder is suffers from, clinic exists
In therapeutic process in addition to wind-dispelling, according to the difference of clinical symptoms, exist expel pathogenic wind from the body surface, expelling wind and removing dampness, expelling wind and activating blood flow, wind-dispelling it is clear
The therapies such as heat, wind-dispelling kidney tonifying, wind-dispelling soothing the liver, and gratifying therapeutic effect is achieved, such as Wang Gang reports, it is posted comprising Radix Angelicae Pubescentis, mulberry
Raw, windproof, radix achyranthis bidentatae, Rhizoma Chuanxiong, the radix paeoniae rubrathe, Radix Rehmanniae, Radix Astragali, periostracum cicada, earthworm, scorpio, caulis sinomenii, stiff silkworm wind-dispelling kidney-nourishing Radix Angelicae Pubescentis
The effective percentage of parasitic soup plus-minus treatment chronic glomerulonephritis is 90.41%, it is shown that Chinese medicine chronic glomerulonephritis
Achieve the effect of preferable.
Although ailment said due to cold or exposure and its clinical symptoms for having aggravated kidney wind such as cold, hot, wet, malicious being mingled with, use while wind-dispelling
The therapy of dampness removing water, heat-clearing, inducing diaphoresis etc. can the effectively clinical symptoms such as alleviating edemas, hypertension, but chronic glomerulonephritis
Also reside in nephrons virtual loss at all, and influence spleen and lung, all evil invasion such as wind, cold, hot, wet, malicious are impairment of the kidney marks for it, and kidney qi is sufficient,
Then aqueous Metabolism of Normal, it is precise and tiny to take the photograph admittedly, without diseases such as oedema, albuminuria, blood urines.Therefore, chronic glomerulus kidney is treated
Inflammation should be aided with wind-dispelling, dampness removing, inducing diaphoresis based on Yishen Jianpi, can realize treating both manifestation and root cause of disease.
The object of the present invention is to provide the Chinese medicine compositions and its system of a kind for the treatment of chronic glomerulonephritis for the treatment of both manifestation and root cause of disease
Preparation Method.
Invention content
Chinese medicine composition and its preparation it is an object of the invention to provide a kind for the treatment of chronic glomerulonephritis for the treatment of both manifestation and root cause of disease
Method.
The Chinese medicine composition of the treatment chronic glomerulonephritis is prepared by following bulk pharmaceutical chemicals：Prepared rehmannia root, Chinese yam, Chinese holly
Qi, dogwood fruit, Semen Cuscutae, tortoise-shell glue, deer horn glue, umbellate pore furgus, Poria cocos, radix bupleuri, Rhizoma Atractylodis Macrocephalae, cassia twig, cicada slough, windproof, rhizoma imperatae, bosom ox
Knee.
Preferably, it is described treatment chronic glomerulonephritis Chinese medicine composition by following parts by weight bulk pharmaceutical chemicals prepare and
Into：15-20 parts of prepared rehmannia root, 10-15 parts of Chinese yam, 10-15 parts of matrimony vine, 5-10 parts of dogwood fruit, 5-10 parts of Semen Cuscutae, tortoise-shell glue 5-10
Part, 5-10 parts of deer horn glue, 10-15 parts of umbellate pore furgus, 10-15 parts of Poria cocos, 5-10 parts of radix bupleuri, 5-10 parts of Rhizoma Atractylodis Macrocephalae, 3-5 parts of cassia twig, cicada slough
3-5 parts, 5-10 parts windproof, 5-10 parts of rhizoma imperatae, 5-10 parts of radix achyranthis bidentatae.
Preferably, it is described treatment chronic glomerulonephritis Chinese medicine composition by following parts by weight bulk pharmaceutical chemicals prepare and
Into：18 parts of prepared rehmannia root, 12 parts of Chinese yam, 12 parts of matrimony vine, 8 parts of dogwood fruit, 8 parts of Semen Cuscutae, 6 parts of tortoise-shell glue, 6 parts of deer horn glue, umbellate pore furgus
12 parts, 12 parts of Poria cocos, 6 parts of radix bupleuri, 8 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of cassia twig, 4 parts of cicada slough, 9 parts windproof, 8 parts of rhizoma imperatae, 8 parts of radix achyranthis bidentatae.
It is also another object of the present invention to provide a kind of preparation method for the Chinese medicine composition for treating chronic glomerulonephritis,
Include the following steps：
(1) it stocks up：Each bulk pharmaceutical chemicals are weighed according to formula；
(2) it pre-processes：By the prepared rehmannia root of formula ratio, Chinese yam, matrimony vine, dogwood fruit, Semen Cuscutae, umbellate pore furgus, Poria cocos, radix bupleuri, white
Art, cassia twig, cicada slough, windproof, fresh cogongrass, radix achyranthis bidentatae are ground into coarse powder and obtain powder 1；By the tortoise-shell glue of formula ratio, deer horn rubber pulverizing
It sieves with 100 mesh sieve, it is spare to obtain powder 2；
(3) ethyl alcohol extracts：Powder 1 is taken to add in the 3-5 times of 60-90% ethyl alcohol measured extraction three times, first time 1.5-3 hour,
Second and third time 0.5-1.5 hours each, merges extracting solution, recycles ethyl alcohol, and relative density is 1.15~1.25 when being concentrated into 50 DEG C
Medicinal extract；
(4) mixing and preparation：Powder 2 is added into after adding pharmaceutically acceptable auxiliary material after medicinal extract obtained by step (3)
It is prepared into Chinese medicine composition of the oral preparation to get present invention treatment chronic glomerulonephritis.
Preferably, step (3) ethyl alcohol extracts：80% ethyl alcohol that powder 1 adds in 4 times of amounts is taken to extract three times, 2 is small for the first time
When, each 1 hour of second and third time merges extracting solution, recycles ethyl alcohol, and relative density is 1.15~1.25 leaching when being concentrated into 50 DEG C
Cream.
The preferred pharmaceutically acceptable auxiliary material is selected from：Filler, adhesive, disintegrant, lubricant, coating agent
Deng.
Preferably, the filler is selected from：Starch, microcrystalline cellulose, lactose, dextrin etc., described adhesive be selected from ethyl alcohol,
Starch slurry, sodium carboxymethylcellulose etc., the disintegrant are selected from sodium carboxymethyl starch, crosslinked polyvinylpyrrolidone, crosslinking carboxylic
Sodium carboxymethylcellulose pyce etc., the lubricant are selected from magnesium stearate, talcum powder, superfine silica gel powder etc..
The preferred oral preparation is selected from：Tablet, capsule, pill, granule, oral liquid etc..
The preferred oral preparation is selected from：Tablet, capsule or oral liquid.
Prepared rehmannia root nourishing kidney yin, growth-promoting yin-fluid in the Chinese medicine composition of present invention treatment chronic glomerulonephritis, dogwood fruit
Kidney is supported with matrimony vine and puckery essence, deer horn glue kidney tonifying and promoting vital essence and blood genernation strengthen the bone, tortoise-shell glue enriching yin and kidney-nourishing, Semen Cuscutae warm kidney and establishing-Yang,
Cassia twig temperature male wind-supplying kidney, the deficiency of Yin that radix achyranthis bidentatae is nourishing liver and kidney, Chinese yam spleen-strengtheningporridge kidney-nourishing remove spleen and lung abnormal heat, and Rhizoma Atractylodis Macrocephalae air making-up and spleen enlivening, negative and positive are simultaneously
It mends, sun is sought in tonifying yin, and the benefits of Yishen Jianpi consolidates and lasting.For umbellate pore furgus with Poria cocos invigorating the spleen, clearing damp, Li Shui without feeling frustrated, rhizoma imperatae is clear
It is turbid can to rush down kidney for hot diuresis.In radix bupleuri and inducing diaphoresis, yang invigorating is windproof to deliver wind-dispelling, and expel endogenous wind to relieve convulsion, cicada slough dredging collateral searches wind, jointly
Achieve the purpose that wind-dispelling.
Advantageous effect of the present invention
1. the Chinese medicine composition reasonable recipe of present invention treatment chronic glomerulonephritis, treating both manifestation and root cause of disease can reach kidney yin sun
The effect of giving young employees remedial-courses in general knowledge and vocational skills, kidney tonifying effect consolidate persistently, and by kidney and spleen invigorating kidney essense abundance, spleen fortune is strong, albumen and blood row in
Normal road, fundamentally treatment chronic glomerulonephritis nephrons loss while, can also effectively alleviate albuminuria, blood urine,
The symptoms such as hypertension, suitable for the treatment of various chronic glomerulonephritis patients.
2. the Chinese medicine composition prescription of present invention treatment chronic glomerulonephritis is simple and easy to get, safe and free of toxic and side effects, can
It avoids further injuring caused by drug administration is kidney.
3. the Chinese medicine composition preparation method of present invention treatment chronic glomerulonephritis is simple, convenient for industrialized production.
Specific embodiment
The present invention is described below in more detail to contribute to the understanding of the present invention.
Embodiment 1:A kind of Chinese medicinal tablet for treating chronic glomerulonephritis
It is prepared by the bulk pharmaceutical chemicals of following weight：Prepared rehmannia root 54g, Chinese yam 36g, matrimony vine 36g, dogwood fruit 24g, Semen Cuscutae
It is 24g, tortoise-shell glue 18g, deer horn glue 18g, umbellate pore furgus 36g, Poria cocos 36g, radix bupleuri 18g, Rhizoma Atractylodis Macrocephalae 24g, cassia twig 12g, cicada slough 12g, windproof
27g, rhizoma imperatae 24g, radix achyranthis bidentatae 24g；
It prepares in accordance with the following methods：
(1) it stocks up：Each bulk pharmaceutical chemicals are weighed according to formula；
(2) it pre-processes：By the prepared rehmannia root of formula ratio, Chinese yam, matrimony vine, dogwood fruit, Semen Cuscutae, umbellate pore furgus, Poria cocos, radix bupleuri, white
Art, cassia twig, cicada slough, windproof, fresh cogongrass, radix achyranthis bidentatae are ground into coarse powder and obtain powder 1；By the tortoise-shell glue of formula ratio, deer horn rubber pulverizing
It sieves with 100 mesh sieve, it is spare to obtain powder 2；
(3) ethyl alcohol extracts：80% ethyl alcohol that powder 1 adds in 4 times of amounts is taken to extract three times, 2 hours for the first time, second and third time
Each 1 hour, merge extracting solution, recycle ethyl alcohol, relative density is 1.15~1.25 medicinal extract when being concentrated into 50 DEG C；
(4) mixing and preparation：After powder 2 is added into medicinal extract obtained by step (3), starch slurry softwood is added, through 14-16
It is dry after mesh sieve whole grain, after gained dry particl crosses 14 mesh sieve whole grain, tabletting after addition Magnesium Stearate proper quantity, totally 1000, gained
Tablet film coating to obtain the final product.
Embodiment 2：A kind of Chinese medicine capsules for treating chronic glomerulonephritis
It is prepared by the bulk pharmaceutical chemicals of following weight：Prepared rehmannia root 45g, Chinese yam 30g, matrimony vine 30g, dogwood fruit 15g, Semen Cuscutae
It is 15g, tortoise-shell glue 15g, deer horn glue 15g, umbellate pore furgus 30g, Poria cocos 30g, radix bupleuri 15g, Rhizoma Atractylodis Macrocephalae 15g, cassia twig 9g, cicada slough 9g, windproof
15g, rhizoma imperatae 15g, radix achyranthis bidentatae 15g；
It prepares in accordance with the following methods：
(1) it stocks up：Each bulk pharmaceutical chemicals are weighed according to formula；
(2) it pre-processes：By the prepared rehmannia root of formula ratio, Chinese yam, matrimony vine, dogwood fruit, Semen Cuscutae, umbellate pore furgus, Poria cocos, radix bupleuri, white
Art, cassia twig, cicada slough, windproof, fresh cogongrass, radix achyranthis bidentatae are ground into coarse powder and obtain powder 1；By the tortoise-shell glue of formula ratio, deer horn rubber pulverizing
It sieves with 100 mesh sieve, it is spare to obtain powder 2；
(3) ethyl alcohol extracts：80% ethyl alcohol that powder 1 adds in 4 times of amounts is taken to extract three times, 2 hours for the first time, second and third time
Each 1 hour, merge extracting solution, recycle ethyl alcohol, relative density is 1.15~1.25 medicinal extract when being concentrated into 50 DEG C；
(4) mixing and preparation：After powder 2 is added into medicinal extract obtained by step (3), starch slurry softwood is added, through 14-16
It is dry after mesh sieve whole grain, after gained dry particl crosses 14 mesh sieve whole grain, gelatine capsule shell is packed into after adding Magnesium Stearate proper quantity, altogether
1000 to get.
Embodiment 3：A kind of Chinese herbal granules for treating chronic glomerulonephritis
It is prepared by the bulk pharmaceutical chemicals of following weight：Prepared rehmannia root 60g, Chinese yam 45g, matrimony vine 45g, dogwood fruit 30g, Semen Cuscutae
It is 30g, tortoise-shell glue 30g, deer horn glue 30g, umbellate pore furgus 45g, Poria cocos 45g, radix bupleuri 30g, Rhizoma Atractylodis Macrocephalae 30g, cassia twig 15g, cicada slough 15g, windproof
30g, rhizoma imperatae 30g, radix achyranthis bidentatae 30g；
It prepares in accordance with the following methods：
(1) it stocks up：Each bulk pharmaceutical chemicals are weighed according to formula；
(2) it pre-processes：By the prepared rehmannia root of formula ratio, Chinese yam, matrimony vine, dogwood fruit, Semen Cuscutae, umbellate pore furgus, Poria cocos, radix bupleuri, white
Art, cassia twig, cicada slough, windproof, fresh cogongrass, radix achyranthis bidentatae are ground into coarse powder and obtain powder 1；By the tortoise-shell glue of formula ratio, deer horn rubber pulverizing
It sieves with 100 mesh sieve, it is spare to obtain powder 2；
(3) ethyl alcohol extracts：80% ethyl alcohol that powder 1 adds in 4 times of amounts is taken to extract three times, 2 hours for the first time, second and third time
Each 1 hour, merge extracting solution, recycle ethyl alcohol, relative density is 1.15~1.25 medicinal extract when being concentrated into 50 DEG C；
(4) mixing and preparation：After powder 2 is added into medicinal extract obtained by step (3), addition lactose, starch slurry softwood, warp
It is dry after 14-16 mesh sieve whole grain, after gained dry particl crosses 14 mesh sieve whole grain, 500 bags are distributed into after adding appropriate magnesium stearate, i.e.,
.
Comparative example 1：Duhuo jisheng decoction is added and subtracted：Radix Angelicae Pubescentis 10g, Ramulus Taxilli 15g, windproof 10g, radix achyranthis bidentatae 15g, Rhizoma Chuanxiong 12g are red
Chinese herbaceous peony 12g, Radix Rehmanniae 10g, Radix Astragali 20g, periostracum cicada 6g, earthworm 15g, scorpio 5g, caulis sinomenii 20g, stiff silkworm 10g.
Comparative example 2：A kind of Chinese medicine composition for treating chronic glomerulonephritis
It is prepared by the bulk pharmaceutical chemicals of following weight：Herba Epimedii 54g, Chinese yam 36g, matrimony vine 36g, dogwood fruit 24g, Semen Cuscutae
24g, deer horn glue 18g, umbellate pore furgus 36g, Poria cocos 36g, radix bupleuri 18g, Rhizoma Atractylodis Macrocephalae 24g, cassia twig 12g, cicada slough 12g, windproof 27g, rhizoma imperatae
24g, radix achyranthis bidentatae 24g are prepared according to 1 method of embodiment.
Comparative example 3：A kind of Chinese medicine composition for treating chronic glomerulonephritis
It is prepared by the bulk pharmaceutical chemicals of following weight：Prepared rehmannia root 12g, Chinese yam 36g, matrimony vine 36g, dogwood fruit 24g, Semen Cuscutae
It is 24g, tortoise-shell glue 18g, deer horn glue 18g, umbellate pore furgus 36g, Poria cocos 36g, radix bupleuri 18g, Rhizoma Atractylodis Macrocephalae 24g, cassia twig 12g, cicada slough 36g, windproof
36g, rhizoma imperatae 24g, radix achyranthis bidentatae 24g are prepared according to 1 method of embodiment.
Effect example 1：Chinese medicine composition causes adriamycin the influence of Chronic Glomerulonephritis Rats Urine proteins
1.1 experimental drug
By medicinal extract obtained by 1 step of embodiment (3) and 2 mixture of powder, 1 medicinal extract of comparative example, comparative example 2-3 steps (3) institute
Obtain suspension of the medicinal extract with 2 mixture of powder using normal saline into 5g crude drugs/mL.
1.2 experimental animal
SD rats, 40,170 ± 20g of weight, after adaptability raises 3d, it is quiet to randomly select 5 big rat-tail for half male and half female
Arteries and veins injecting normal saline 7.5mg/Kg, as normal group, remaining 35 rats are disposably in tail vein injection doxorubicin hydrochloride
7.5mg/Kg weight, as modeling group, rat is individually placed in metabolic cage by normal raising after a week, is collected urine for 24 hours, is made
Rat urine protein content for 24 hours is measured with wolframic acid method, rat of the screening twenty-four-hour urine albumen more than 10mg is randomly divided into five groups, every group
5, respectively model group, 1 group of embodiment, comparative example 1-3 groups normally feed until experiment terminates each group rat, wherein implementing
1 group of example and comparative example 1-3 group gastric infusion relative medicines, gavage amount are 0.5mL/100g weight, are administered once daily, continuously give
Medicine 21 days measures rat urine protein content for 24 hours after administration administration in the 7th, 14,21 day, specifically met and be shown in Table 1 again.
1.3 experimental result
The multifactor analysis of variance module of applied statistics software SPSS carries out data analysis, P<0.05 expression difference has statistics
Learn meaning.
1 Chinese medicine composition of table causes adriamycin the influence of Chronic Glomerulonephritis Rats Urine proteins
Compared with model group：*P<0.05,**P<0.01.
1 experimental result of table shows, the twenty-four-hour urine protein contents of model group rats for normally organizing apparent increase, and with
The progress of experiment, is gradually increased, shows the chronic nephritis of model group rats with the progress of experiment and progressive aggravates.Although
It is roughly the same that first day 1 group of embodiment, comparative example 1-3 groups and the twenty-four-hour urine protein content of model group rats is administered, but embodiment 1
Group Chronic Glomerulonephritis Rats twenty-four-hour urine protein content when being administered the 7th day has been presented relative to model group to be substantially reduced, until administration
21st day embodiment 1 group of Rat 24 h urine albumen amount with normally organize it is roughly the same, it was demonstrated that 1 Chinese medicine of the embodiment of the present application
Composition has excellent chronic nephritis therapeutic effect, can quickly correct the albuminuria of Chronic Glomerulonephritis Rats.
The twenty-four-hour urine protein content that 1 group of Chinese medicine composition of comparative example is administered the 7th day is also shown for first day relative to administration
A degree of reduction, so as to show that 1 group of Chinese medicine composition of comparative example also there are certain reduction Chronic Glomerulonephritis Rats to urinate egg
The effect measured in vain, but with the dosage form of experiment, 1 group of Rat 24 h urine albumen amount of comparative example still show becoming of gradually increasing
Gesture shows that 1 group of Chinese medicine composition of comparative example is only capable of delaying the deterioration of rat chronic ephritis.
Prepared rehmannia root in 1 group of Chinese medicine composition of the embodiment of the present application is only replaced with excessive sheep by 2 groups of Chinese medicine compositions of comparative example
The leaves of pulse plants eliminates the tortoise-shell glue of nourishing YIN for benefiting the kidney.2 groups of Rat 24 h urine albumen amounts of comparative example relative to model group the 7th day, the 14th
It and also present within the 21st day a degree of reduction, but reduce amplitude and be obviously reduced, with the carry out chronic nephritis of experiment
The twenty-four-hour urine protein content of rat, which is still presented, to be gradually increased, it is shown that 2 groups of Chinese medicine compositions of comparative example are replaced with by prepared rehmannia root
Herba Epimedii is also only capable of playing the role of that rat chronic ephritis is delayed to deteriorate after eliminating the tortoise-shell glue of nourishing YIN for benefiting the kidney.
3 groups of Chinese medicine compositions of comparative example reduce the dosage of kidney tonifying class drug relative to 1 group of Chinese medicine composition of embodiment, right
The twenty-four-hour urine protein content of 3 groups of Chinese medicine compositions of ratio Chronic Glomerulonephritis Rats when being administered the 7th day is roughly the same with model group, gives
Medicine then presents a degree of reduction on the 14th day relative to model group, is substantially reduced when being administered the 21st day relative to model group,
Showing 3 groups of Chinese medicine compositions of comparative example also has the effect for the treatment of rat chronic ephritis, but subtracting due to kidney-nourishing drug dose
Less, it is slower to result in drug effect, and overall treatment effect is substantially reduced relative to 1 group of Chinese medicine composition of embodiment.
Effect example 2：The clinical therapeutic efficacy of Chinese medicine composition chronic glomerulonephritis
2.1 experimental subjects
Patients with chronic glomerulonephritis 138, age are 28-64 Sui, and wherein male 97, women 41 is randomly divided into two groups, point
Not Wei 3 groups of 1 group of embodiment and comparative example, every group 69.
2.2 experimental drug
3 groups of 1 group of Chinese medicinal tablet of embodiment, comparative example Chinese medicinal tablets.
2.3 experimental method
1 group of embodiment takes 3 groups of Chinese medicinal tablets of 1 group of Chinese medicinal tablet of embodiment and comparative example respectively with 3 groups of patients of comparative example,
4 tablets once, twice daily, continuously takes 30 days, and observation each group patient cures, effective, effective and invalid number of cases, calculates effective
Rate, specific experiment the results are shown in Table 2, wherein：Efficient=(curing number of cases+effective number of cases)/total Li Shuo ╳ 100%.
2.4 diagnostic criteria
It cures：Renal hypertension completely disappears, and albuminuria continues negative, urine erythrocyte and continues feminine gender, twenty-four-hour urine
Protein content<200mg；
Effectively：Renal hypertension is alleviated substantially, and urine erythrocyte is normal, before medication, twenty-four-hour urine protein content
Reduce 50%；
It is effective：Renal hypertension improves, and urine erythrocyte is reduced, and before medication, twenty-four-hour urine protein content does not increase
Add；
In vain：Renal hypertension deteriorates, urine erythrocyte and twenty-four-hour urine protein content gradually increase.
2.5 experimental result
The clinical therapeutic efficacy of 2 Chinese medicine composition chronic glomerulonephritis of table
| Group | Number of cases | It cures | Effectively | It is effective | In vain | It is efficient |
| 1 group of embodiment | 69 | 58 | 10 | 1 | 0 | 98.55% |
| 3 groups of comparative example | 69 | 22 | 34 | 8 | 5 | 81.16% |
2 experimental result of table, which is shown, takes 1 group of embodiment of the present invention Chinese medicinal tablet 30 days, can effectively treat chronic glomerulus
Ephritis, effective percentage have reached 98.55%, hence it is evident that better than the comparison that therapeutic effect is also showed that in the experiment of rat chronic ephritis
3 groups of Chinese medicinal tablets of example.
The foregoing describe the preferred embodiment for the present invention, and however, it is not to limit the invention.Those skilled in the art couple
Embodiment disclosed herein can carry out improvement and the variation without departing from scope and spirit.
Claims (9)
1. a kind of Chinese medicine composition for treating chronic glomerulonephritis, it is characterised in that be prepared by following bulk pharmaceutical chemicals：Cultivated land
Huang, Chinese yam, matrimony vine, dogwood fruit, Semen Cuscutae, tortoise-shell glue, deer horn glue, umbellate pore furgus, Poria cocos, radix bupleuri, Rhizoma Atractylodis Macrocephalae, cassia twig, cicada slough, it is windproof,
Rhizoma imperatae, radix achyranthis bidentatae.
2. the Chinese medicine composition for the treatment of chronic glomerulonephritis according to claim 1, it is characterised in that by following weight
The bulk pharmaceutical chemicals of part are prepared：15-20 parts of prepared rehmannia root, 10-15 parts of Chinese yam, 10-15 parts of matrimony vine, 5-10 parts of dogwood fruit, Semen Cuscutae
5-10 parts, 5-10 parts of tortoise-shell glue, 5-10 parts of deer horn glue, 10-15 parts of umbellate pore furgus, 10-15 parts of Poria cocos, 5-10 parts of radix bupleuri, Rhizoma Atractylodis Macrocephalae 5-10
Part, 3-5 parts of cassia twig, 3-5 parts of cicada slough, 5-10 parts windproof, 5-10 parts of rhizoma imperatae, 5-10 parts of radix achyranthis bidentatae.
3. the Chinese medicine composition for the treatment of chronic glomerulonephritis according to claim 1 or 2, it is characterised in that by following heavy
The bulk pharmaceutical chemicals of amount part are prepared：18 parts of prepared rehmannia root, 12 parts of Chinese yam, 12 parts of matrimony vine, 8 parts of dogwood fruit, 8 parts of Semen Cuscutae, tortoise-shell glue 6
Part, 6 parts of deer horn glue, 12 parts of umbellate pore furgus, 12 parts of Poria cocos, 6 parts of radix bupleuri, 8 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of cassia twig, 4 parts of cicada slough, 9 parts windproof, rhizoma imperatae
8 parts, 8 parts of radix achyranthis bidentatae.
4. the Chinese medicine composition for the treatment of chronic glomerulonephritis according to claim 3, it is characterised in that the Chinese medicine group
Object is closed to be selected from：Tablet, capsule, pill, granule, oral liquid.
5. the Chinese medicine composition for the treatment of chronic glomerulonephritis according to claim 4, it is characterised in that the Chinese medicine group
Object is closed to be selected from：Tablet, capsule, granule.
6. the preparation method of the Chinese medicine composition of claim 1-5 any one of them treatment chronic glomerulonephritis, feature
It is to include the following steps：
(1) it stocks up：Each bulk pharmaceutical chemicals are weighed according to formula；
(2) it pre-processes：By the prepared rehmannia root of formula ratio, Chinese yam, matrimony vine, dogwood fruit, Semen Cuscutae, umbellate pore furgus, Poria cocos, radix bupleuri, Rhizoma Atractylodis Macrocephalae, osmanthus
Branch, cicada slough, windproof, fresh cogongrass, radix achyranthis bidentatae are ground into coarse powder and obtain powder 1；The tortoise-shell glue of formula ratio, deer horn glue crushed 100
Mesh sieves, and it is spare to obtain powder 2；
(3) ethyl alcohol extracts：Powder 1 is taken to add in the 3-5 times of 60-90% ethyl alcohol measured extraction three times, first time 1.5-3 hour, second,
It is 0.5-1.5 hours each three times, merge extracting solution, recycle ethyl alcohol, relative density is 1.15~1.25 medicinal extract when being concentrated into 50 DEG C；
(4) mixing and preparation：Powder 2 is added into after adding pharmaceutically acceptable auxiliary material after medicinal extract obtained by step (3) and prepared
Into corresponding dosage form to get.
7. preparation method according to claim 6, it is characterised in that：Step (3) the ethyl alcohol extraction：Powder 1 is taken to add in 4
Three times, 2 hours for the first time, each 1 hour of second and third time, merging extracting solution recycled ethyl alcohol, concentration for the 80% ethyl alcohol extraction of amount again
To the medicinal extract that relative density at 50 DEG C is 1.15~1.25.
8. preparation method according to claim 6, it is characterised in that：The pharmaceutically acceptable auxiliary material is selected from：Filling
Agent, adhesive, disintegrant, lubricant, coating agent.
9. preparation method according to claim 8, it is characterised in that:The filler is selected from：Starch, microcrystalline cellulose,
Lactose, dextrin, described adhesive are selected from ethyl alcohol, starch slurry, sodium carboxymethylcellulose etc., and the disintegrant is selected from carboxymethyl starch
Sodium, crosslinked polyvinylpyrrolidone, croscarmellose sodium, the lubricant are selected from magnesium stearate, talcum powder, micro mist silicon
Glue.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810088730.XA CN108186918B (en) | 2018-01-30 | 2018-01-30 | Traditional Chinese medicine composition for treating chronic glomerulonephritis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810088730.XA CN108186918B (en) | 2018-01-30 | 2018-01-30 | Traditional Chinese medicine composition for treating chronic glomerulonephritis and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108186918A true CN108186918A (en) | 2018-06-22 |
| CN108186918B CN108186918B (en) | 2021-04-13 |
Family
ID=62591811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810088730.XA Active CN108186918B (en) | 2018-01-30 | 2018-01-30 | Traditional Chinese medicine composition for treating chronic glomerulonephritis and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108186918B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559468A (en) * | 2004-02-27 | 2005-01-05 | 李国成 | Medicine for treating chronic nephritis, and its prepn. method |
-
2018
- 2018-01-30 CN CN201810088730.XA patent/CN108186918B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559468A (en) * | 2004-02-27 | 2005-01-05 | 李国成 | Medicine for treating chronic nephritis, and its prepn. method |
Non-Patent Citations (2)
| Title |
|---|
| 何明等: "中西医结合治疗原发性肾病综合征临床观察", 《湖北中医杂志》 * |
| 龚姿榕等: "从肾有虚实论治慢性肾病探讨", 《中国民族民间医药》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108186918B (en) | 2021-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110787233B (en) | Liver-protecting traditional Chinese medicine composition, extract and pharmaceutical application thereof | |
| CN103990081A (en) | Traditional Chinese medicine composition and application thereof in preparation of medicine for treating infant jaundice | |
| CN103263659B (en) | Traditional Chinese medicine composition for treating rheumatism bone diseases | |
| CN101711848B (en) | Chinese medicinal composition capable of adjunctively treating tumour | |
| CN102671178B (en) | Preparation method of Chinese medicinal composition for treating nephrotic syndrome and uremia and application thereof | |
| CN104825963A (en) | Traditional Chinese medicinal preparation for treating habitual abortion, and preparation method thereof | |
| CN102106965B (en) | Composition for treating acute injury of soft tissue and application thereof | |
| CN103301267A (en) | Traditional Chinese medicine composition for treating hypertension and/or atherosclerosis and application thereof | |
| CN102657736B (en) | Medicament composition for treating rheumatoid arthritis and preparation method of medicament composition | |
| CN104027684A (en) | Traditional Chinese medicinal composition for treating gout and preparation method thereof | |
| CN101530594B (en) | Ultra-fine grain traditional Chinese medicine defibrination paste used for treating liver cirrhosis | |
| CN103341092A (en) | Preparation method of powder for treating atrophic vaginitis | |
| CN104888157A (en) | Traditional Chinese medicine preparation for treating hysteromyoma and preparation method thereof | |
| CN1052889C (en) | Chinese proprietary for curing hepatitis | |
| CN103705846A (en) | Traditional Chinese medicine preparation for treating ovarian cyst | |
| CN103142751B (en) | Traditional Chinese medicine composition for treating piglet iron-deficiency anemia | |
| CN108186918A (en) | A kind of Chinese medicine composition for treating chronic glomerulonephritis and preparation method thereof | |
| CN104887950A (en) | Mastitis treatment traditional Chinese medicine compound | |
| CN103417763B (en) | One treats osteoporotic pharmaceutical composition and its production and use | |
| CN104840891A (en) | Traditional Chinese medicine preparation used for treating alcoholic cardiomyopathy and preparation method thereof | |
| CN107913389A (en) | A kind of Chinese medicine composition for treating Thyroid Gland Swell and preparation method thereof | |
| CN1958006A (en) | Preparation of Chinese traditional medicine for healthy chest and plumpy breasts | |
| CN105920539A (en) | Medicament for treating foot-and-mouth disease of sheep | |
| CN105434533A (en) | Traditional Chinese medicine composition for treating liver cancer | |
| CN105362999A (en) | Traditional Chinese medicine preparation for preventing and treating infantile repeated cold and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |