CN108186918B - Traditional Chinese medicine composition for treating chronic glomerulonephritis and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating chronic glomerulonephritis and preparation method thereof Download PDF

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CN108186918B
CN108186918B CN201810088730.XA CN201810088730A CN108186918B CN 108186918 B CN108186918 B CN 108186918B CN 201810088730 A CN201810088730 A CN 201810088730A CN 108186918 B CN108186918 B CN 108186918B
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chinese medicine
kidney
chronic glomerulonephritis
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CN108186918A (en
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栾仲秋
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Heilongjiang University of Chinese Medicine
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Abstract

The invention relates to a traditional Chinese medicine composition for treating chronic glomerulonephritis and a preparation method thereof, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines: radix rehmanniae Preparata, rhizoma Dioscoreae, fructus Lycii, Corni fructus, semen Cuscutae, colla Plastri Testudinis, colla Cornus Cervi, Polyporus, Poria, bupleuri radix, Atractylodis rhizoma, ramulus Cinnamomi, periostracum Cicadae, radix Saposhnikoviae, lalang grass rhizome, and Achyranthis radix. The traditional Chinese medicine composition for treating chronic glomerulonephritis has a reasonable formula, can achieve the effect of tonifying yin and yang of the kidney, has a stable and durable kidney tonifying effect, can ensure sufficient kidney essence and strong spleen movement by tonifying the kidney and strengthening the spleen, and allows protein and blood to flow in a normal way, can effectively relieve symptoms of proteinuria, hematuria, hypertension and the like while fundamentally treating the kidney essence deficiency of the chronic glomerulonephritis, treats both symptoms and root causes, and is suitable for treating various chronic glomerulonephritis patients.

Description

Traditional Chinese medicine composition for treating chronic glomerulonephritis and preparation method thereof
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating chronic glomerulonephritis and a preparation method thereof.
Background
Chronic glomerulonephritis, called chronic nephritis for short, is a group of diseases with long disease course caused by various primary glomerular diseases and clinically manifested by proteinuria, hematuria, edema, hypertension and the like. Chronic glomerulonephritis is difficult to treat, has poor prognosis, and can cause severe complications such as anemia, uremia and retinopathy along with the progress of the disease, and most chronic glomerulonephritis evolves into chronic renal failure.
Aiming at chronic glomerulonephritis, western medicine generally adopts symptomatic treatment at present, except that the intake of sodium and protein in diet is limited, and the blood pressure is reduced, the deterioration of the state of an illness is generally delayed by taking glucocorticoid and immunosuppressant, although a certain symptomatic treatment effect is obtained, adverse reactions such as peptic ulcer, osteoporosis, aseptic femoral head necrosis and the like caused by infection are often induced or even aggravated, and therefore, an ideal curative effect cannot be obtained.
The chronic glomerulonephritis generally belongs to the categories of edema, lumbago, hematuria, stranguria and the like in the traditional Chinese medicine, so different treatment methods such as spleen strengthening, kidney tonifying, heat clearing, dampness removing, blood circulation promoting, collateral dredging and the like exist for the chronic glomerulonephritis, and a certain curative effect is obtained, for example, according to reports of Baizheng theory and the like, the Ningshui decoction containing Chinese yam, astragalus, glossy privet fruit, pyrrosia lingua, cicada slough, fructus forsythiae and leech can remarkably improve the treatment of proteinuria, hematuria, renal function and the like of a patient with the chronic glomerulonephritis, and can effectively delay the pathological process of the chronic glomerulonephritis. The characteristics of slow progress, difficult treatment and poor prognosis of chronic glomerulonephritis proposed by scholars belong to the category of kidney-wind in traditional Chinese medicine, and the kidney-wind is generated by the invasion of pathogenic wind into the human body, the invasion of the pathogenic wind along the channels and the injury of the kidney. Wind pathogen has the characteristics of being capable of rising, dispersing, ascending and outward, generally easily invades yang positions of throat, waist and back and the like, when the wind pathogen is in the kidney, the kidney can not store essence, essence and qi are excreted to form proteinuria, the wind pathogen penetrates through kidney membrane and blood collaterals to cause membrane collaterals to be damaged, blood can be excreted to form hematuria, the wind is the long of all diseases, cold, heat, dampness, toxin and the like can adhere to the wind pathogen to invade the human body, so that the kidney is damaged, the early stage shows wind cold, wind-dampness, wind-heat, damp-heat and the like, and the later stage shows damp turbidity, blood stasis and the like. Because the cause of kidney-wind is wind, wind-herbs such as Ma Huang, Fang Feng, Han Fang Ji, Chan tui, Lemna minor, Qing Feng Teng and Tripterygium wilfordii are used for kidney-wind. Because wind evil is always accompanied by a disease, clinically, except for dispelling wind in the treatment process, according to different clinical symptoms, treatment methods of dispelling wind, relieving exterior syndrome, dispelling wind, promoting diuresis, dispelling wind, activating blood circulation, dispelling wind, clearing heat, dispelling wind, tonifying kidney, dispelling wind, calming liver and the like exist, and favorable treatment effects are obtained, for example, in the report of Wanggang and the like, the effective rate of treating chronic glomerulonephritis by adding the wind-dispelling and kidney-tonifying radix angelicae pubescentis and Chinese taxillus herb decoction containing radix angelicae pubescentis, loranthus parasiticus, radix sileris, radix achyranthis bidentatae, ligusticum wallichii, radix paeoniae rubra, radix rehmanniae, radix astragali, periostracum cicadae, earthworm, scorpion, caulis sinomenii acutissimae and stiff silkworm is 90.41%, and the traditional Chinese medicine is shown to.
Although wind and its complicated cold, heat, dampness, toxicity, etc. aggravate the clinical symptoms of kidney wind, the treatment methods of inducing diuresis, clearing heat, relieving exterior syndrome, etc. are adopted to effectively relieve the clinical symptoms of edema, hypertension, etc. while dispelling wind, the chronic glomerulonephritis is also characterized by kidney deficiency and affecting spleen and lung, and the symptoms of the invasion and injury of kidney by various pathogens of wind, cold, heat, dampness, toxicity, etc. are sufficient kidney qi, so that the water metabolism is normal, and the essence is kept in balance, and the symptoms of edema, proteinuria, hematuria, etc. can not appear. Therefore, the treatment of chronic glomerulonephritis mainly aims at tonifying kidney and spleen, and is assisted with dispelling wind, promoting diuresis and relieving exterior syndrome, so that both symptoms and root causes can be realized.
The invention aims to provide a traditional Chinese medicine composition for treating chronic glomerulonephritis and a preparation method thereof.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating chronic glomerulonephritis and a preparation method thereof.
The traditional Chinese medicine composition for treating chronic glomerulonephritis is prepared from the following raw material medicines: radix rehmanniae Preparata, rhizoma Dioscoreae, fructus Lycii, Corni fructus, semen Cuscutae, colla Plastri Testudinis, colla Cornus Cervi, Polyporus, Poria, bupleuri radix, Atractylodis rhizoma, ramulus Cinnamomi, periostracum Cicadae, radix Saposhnikoviae, lalang grass rhizome, and Achyranthis radix.
Preferably, the traditional Chinese medicine composition for treating chronic glomerulonephritis is prepared from the following raw material medicines in parts by weight: 15-20 parts of prepared rehmannia root, 10-15 parts of Chinese yam, 10-15 parts of medlar, 5-10 parts of dogwood fruit, 5-10 parts of dodder, 5-10 parts of tortoise-plastron glue, 5-10 parts of deerhorn glue, 10-15 parts of polyporus umbellatus, 10-15 parts of tuckahoe, 5-10 parts of radix bupleuri, 5-10 parts of bighead atractylodes rhizome, 3-5 parts of cassia twig, 3-5 parts of cicada slough, 5-10 parts of divaricate saposhnikovia root, 5-10 parts of lalang grass rhizome and 5-10 parts of radix achyranthis bidentatae.
Preferably, the traditional Chinese medicine composition for treating chronic glomerulonephritis is prepared from the following raw material medicines in parts by weight: 18 parts of prepared rehmannia root, 12 parts of Chinese yam, 12 parts of medlar, 8 parts of cornus, 8 parts of dodder, 6 parts of tortoise-plastron glue, 6 parts of deerhorn glue, 12 parts of polyporus umbellatus, 12 parts of tuckahoe, 6 parts of radix bupleuri, 8 parts of bighead atractylodes rhizome, 4 parts of cassia twig, 4 parts of cicada slough, 9 parts of divaricate saposhnikovia root, 8 parts of lalang grass rhizome and 8 parts of radix achyranthis bidentatae.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating chronic glomerulonephritis, which comprises the following steps:
(1) preparing materials: weighing the raw materials according to a formula;
(2) pretreatment: pulverizing radix rehmanniae Preparata, rhizoma Dioscoreae, fructus Lycii, Corni fructus, semen Cuscutae, Polyporus, Poria, bupleuri radix, Atractylodis rhizoma, ramulus Cinnamomi, periostracum Cicadae, radix Saposhnikoviae, rhizoma Imperatae, and Achyranthis radix into coarse powder to obtain powder 1; crushing the tortoise-plastron glue and the antler glue according to the formula amount, and sieving the crushed tortoise-plastron glue and the antler glue by a 100-mesh sieve to obtain powder 2 for later use;
(3) ethanol extraction: adding 3-5 times of 60-90% ethanol into the powder 1, extracting for three times, wherein the first time lasts for 1.5-3 hours, and the second time and the third time respectively lasts for 0.5-1.5 hours, combining the extracting solutions, recovering the ethanol, and concentrating to obtain an extract with the relative density of 1.15-1.25 at 50 ℃;
(4) mixing and preparing: adding the powder 2 into the extract obtained in the step (3), adding pharmaceutically acceptable auxiliary materials, and preparing into an oral preparation to obtain the traditional Chinese medicine composition for treating chronic glomerulonephritis.
Preferably, the step (3) ethanol extraction: adding 4 times of 80% ethanol into the powder 1, extracting for three times, 2 hours for the first time, 1 hour for the second time and 1 hour for the third time respectively, combining the extracting solutions, recovering the ethanol, and concentrating to obtain an extract with the relative density of 1.15-1.25 at 50 ℃.
Preferably the pharmaceutically acceptable excipients are selected from: fillers, binders, disintegrants, lubricants, coating agents, and the like.
Preferably, the filler is selected from: starch, microcrystalline cellulose, lactose, dextrin and the like, wherein the adhesive is selected from ethanol, starch slurry, sodium carboxymethyl cellulose and the like, the disintegrating agent is selected from sodium carboxymethyl starch, cross-linked polyvinylpyrrolidone, cross-linked sodium carboxymethyl cellulose and the like, and the lubricant is selected from magnesium stearate, talcum powder, superfine silica powder and the like.
Preferably said oral formulation is selected from: tablet, capsule, pill, granule, oral liquid, etc.
More preferably said oral formulation is selected from: tablet, capsule or oral liquid.
The Chinese medicinal composition for treating chronic glomerulonephritis has stable and lasting effects of nourishing kidney yin and promoting yin generation of rehmannia, nourishing kidney and arresting seminal emission of dogwood fruit and Chinese wolfberry, tonifying kidney to generate essence and blood and strengthen bones and muscles by antler glue, nourishing yin and tonifying kidney by tortoise plastron glue, warming kidney to strengthen yang by dodder, warming yang and tonifying kidney by cassia twig, nourishing liver and kidney yin by achyranthes bidentata, tonifying spleen and kidney by Chinese yam, clearing spleen and lung deficiency heat, tonifying qi and spleen by bighead atractylodes rhizome, tonifying yin and yang, tonifying yin and seeking yang, and tonifying kidney and strengthening spleen. Polyporus and Poria have the effects of invigorating spleen, eliminating dampness, and inducing diuresis without hurting qi, and lalang grass rhizome has the effects of clearing heat, promoting diuresis, and purging kidney-turbid pathogen. Radix bupleuri, radix Saposhnikoviae, rhizoma Pinelliae, radix Angelicae sinensis, periostracum Cicadae, radix Angelicae sinensis, and periostracum Cicadae can be used for expelling pathogenic wind.
The invention has the beneficial effects
1. The traditional Chinese medicine composition for treating chronic glomerulonephritis is reasonable in formula, treats both principal and secondary aspects of diseases, can achieve the effect of tonifying yin and yang of kidney, is stable and durable in kidney tonifying effect, enables kidney essence to be sufficient by tonifying kidney and spleen, is strong and strong in spleen movement, enables protein and blood to be in a normal way, can effectively relieve symptoms such as proteinuria, hematuria and hypertension while fundamentally treating kidney essence deficiency of chronic glomerulonephritis, and is suitable for treating various patients with chronic glomerulonephritis.
2. The traditional Chinese medicine composition for treating chronic glomerulonephritis is simple and easy to obtain in formula, safe, free of toxic and side effects, and capable of avoiding further damage to kidneys due to medicine taking.
3. The traditional Chinese medicine composition for treating chronic glomerulonephritis is simple in preparation method and convenient for industrial production.
Detailed Description
The present invention is described in more detail below to facilitate an understanding of the present invention.
Example 1A Chinese medicinal tablet for treating chronic glomerulonephritis
The traditional Chinese medicine is prepared from the following raw materials by weight: 54g of prepared rehmannia root, 36g of Chinese yam, 36g of medlar, 24g of cornus, 24g of dodder, 18g of tortoise-plastron glue, 18g of deerhorn glue, 36g of polyporus umbellatus, 36g of tuckahoe, 18g of radix bupleuri, 24g of bighead atractylodes rhizome, 12g of cassia twig, 12g of cicada slough, 27g of divaricate saposhnikovia root, 24g of lalang grass rhizome and 24g of radix achyranthis bidentatae;
the preparation method comprises the following steps:
(1) preparing materials: weighing the raw materials according to a formula;
(2) pretreatment: pulverizing radix rehmanniae Preparata, rhizoma Dioscoreae, fructus Lycii, Corni fructus, semen Cuscutae, Polyporus, Poria, bupleuri radix, Atractylodis rhizoma, ramulus Cinnamomi, periostracum Cicadae, radix Saposhnikoviae, rhizoma Imperatae, and Achyranthis radix into coarse powder to obtain powder 1; crushing the tortoise-plastron glue and the antler glue according to the formula amount, and sieving the crushed tortoise-plastron glue and the antler glue by a 100-mesh sieve to obtain powder 2 for later use;
(3) ethanol extraction: adding 4 times of 80% ethanol into the powder 1, extracting for three times, 2 hours for the first time, 1 hour for the second time and the third time respectively, combining the extracting solutions, recovering the ethanol, and concentrating to obtain an extract with the relative density of 1.15-1.25 at 50 ℃;
(4) mixing and preparing: adding the powder 2 into the extract obtained in the step (3), adding starch slurry to prepare a soft material, sieving with a 14-16 mesh sieve, drying, sieving the obtained dry granules with a 14 mesh sieve, adding a proper amount of magnesium stearate, tabletting, and coating the obtained tablets with a film coat to obtain the tablet.
Example 2: a Chinese medicinal capsule for treating chronic glomerulonephritis
The traditional Chinese medicine is prepared from the following raw materials by weight: 45g of prepared rehmannia root, 30g of Chinese yam, 30g of medlar, 15g of cornus, 15g of dodder, 15g of tortoise-plastron glue, 15g of deerhorn glue, 30g of polyporus umbellatus, 30g of tuckahoe, 15g of radix bupleuri, 15g of bighead atractylodes rhizome, 9g of cassia twig, 9g of cicada slough, 15g of radix sileris, 15g of lalang grass rhizome and 15g of radix achyranthis bidentatae;
the preparation method comprises the following steps:
(1) preparing materials: weighing the raw materials according to a formula;
(2) pretreatment: pulverizing radix rehmanniae Preparata, rhizoma Dioscoreae, fructus Lycii, Corni fructus, semen Cuscutae, Polyporus, Poria, bupleuri radix, Atractylodis rhizoma, ramulus Cinnamomi, periostracum Cicadae, radix Saposhnikoviae, rhizoma Imperatae, and Achyranthis radix into coarse powder to obtain powder 1; crushing the tortoise-plastron glue and the antler glue according to the formula amount, and sieving the crushed tortoise-plastron glue and the antler glue by a 100-mesh sieve to obtain powder 2 for later use;
(3) ethanol extraction: adding 4 times of 80% ethanol into the powder 1, extracting for three times, 2 hours for the first time, 1 hour for the second time and the third time respectively, combining the extracting solutions, recovering the ethanol, and concentrating to obtain an extract with the relative density of 1.15-1.25 at 50 ℃;
(4) mixing and preparing: adding the powder 2 into the extract obtained in the step (3), adding starch slurry to prepare a soft material, sieving with a 14-16 mesh sieve, drying, sieving the obtained dry particles with a 14 mesh sieve, adding a proper amount of magnesium stearate, and filling into a gelatin capsule shell for 1000 granules.
Example 3: traditional Chinese medicine granules for treating chronic glomerulonephritis
The traditional Chinese medicine is prepared from the following raw materials by weight: 60g of prepared rehmannia root, 45g of Chinese yam, 45g of medlar, 30g of cornus, 30g of dodder, 30g of tortoise-plastron glue, 30g of deerhorn glue, 45g of polyporus, 45g of tuckahoe, 30g of radix bupleuri, 30g of bighead atractylodes rhizome, 15g of cassia twig, 15g of cicada slough, 30g of radix sileris, 30g of lalang grass rhizome and 30g of radix achyranthis bidentatae;
the preparation method comprises the following steps:
(1) preparing materials: weighing the raw materials according to a formula;
(2) pretreatment: pulverizing radix rehmanniae Preparata, rhizoma Dioscoreae, fructus Lycii, Corni fructus, semen Cuscutae, Polyporus, Poria, bupleuri radix, Atractylodis rhizoma, ramulus Cinnamomi, periostracum Cicadae, radix Saposhnikoviae, rhizoma Imperatae, and Achyranthis radix into coarse powder to obtain powder 1; crushing the tortoise-plastron glue and the antler glue according to the formula amount, and sieving the crushed tortoise-plastron glue and the antler glue by a 100-mesh sieve to obtain powder 2 for later use;
(3) ethanol extraction: adding 4 times of 80% ethanol into the powder 1, extracting for three times, 2 hours for the first time, 1 hour for the second time and the third time respectively, combining the extracting solutions, recovering the ethanol, and concentrating to obtain an extract with the relative density of 1.15-1.25 at 50 ℃;
(4) mixing and preparing: adding the powder 2 into the extract obtained in the step (3), adding lactose and starch slurry to prepare a soft material, sieving with a 14-16 mesh sieve, drying, sieving with a 14 mesh sieve, adding a proper amount of magnesium stearate, and subpackaging into 500 bags to obtain the finished product.
Comparative example 1: modified Duhuo Jisheng Tang (decoction of doubleteeth pubescent angelica and Loranthus parasiticus): 10g of radix angelicae pubescentis, 15g of parasitic loranthus, 10g of divaricate saposhnikovia root, 15g of radix achyranthis bidentatae, 12g of ligusticum wallichii, 12g of radix paeoniae rubra, 10g of radix rehmanniae, 20g of astragalus membranaceus, 6g of periostracum cicadae, 15g of earthworm, 5g of scorpion, 20g of caulis sinomenii and 10g of stiff silkworm.
Comparative example 2: traditional Chinese medicine composition for treating chronic glomerulonephritis
The traditional Chinese medicine is prepared from the following raw materials by weight: 54g of epimedium herb, 36g of Chinese yam, 36g of medlar, 24g of cornus, 24g of dodder, 18g of deerhorn glue, 36g of polyporus umbellatus, 36g of tuckahoe, 18g of radix bupleuri, 24g of bighead atractylodes rhizome, 12g of cassia twig, 12g of cicada slough, 27g of divaricate saposhnikovia root, 24g of lalang grass rhizome and 24g of radix achyranthis bidentatae, and the preparation method is carried out according to the embodiment 1.
Comparative example 3: traditional Chinese medicine composition for treating chronic glomerulonephritis
The traditional Chinese medicine is prepared from the following raw materials by weight: 12g of prepared rehmannia root, 36g of Chinese yam, 36g of medlar, 24g of cornus officinalis, 24g of dodder, 18g of tortoise-plastron glue, 18g of deerhorn glue, 36g of polyporus umbellatus, 36g of poria cocos, 18g of radix bupleuri, 24g of bighead atractylodes rhizome, 12g of cassia twig, 36g of cicada slough, 36g of divaricate saposhnikovia root, 24g of lalang grass rhizome and 24g of radix achyranthis bidentatae, and the preparation method is carried out according to the embodiment 1.
Effect example 1: influence of traditional Chinese medicine composition on chronic nephritis induced by adriamycin and rat urine protein
1.1 Experimental drugs
The mixture of the extract obtained in the step (3) of the example 1 and the powder 2, the extract obtained in the comparative example 1, and the mixture of the extract obtained in the step (3) of the comparative examples 2 to 3 and the powder 2 are prepared into a suspension of 5g crude drug/mL by using normal saline.
1.2 Experimental animals
SD rats 40 with body weight of 170 +/-20 g and female and male halves are adaptively raised for 3 days, 5 rats are randomly selected and are respectively placed in a metabolism cage after being fed normally for one week, urine for 24 hours is collected, the content of urine protein of the rats for 24 hours is measured by a tungstic acid method, the remaining 35 rats are randomly divided into five groups after being injected with doxorubicin hydrochloride for 7.5mg/Kg at the tail vein, each group of 5 rats is respectively a model group, an example 1 group and a comparative example 1-3 group until the experiment is finished, wherein the rats in the example 1 group and the comparative example 1-3 groups are normally fed, the corresponding medicines are intragastrically administered, the intragastric administration amount is 0.5mL/100g body weight, the administration is performed for 1 time per day, the continuous administration is performed for 21 days, and the administration periods 7, 7, 14. The 24h urine protein content of the rats was again determined after 21 days of administration, as shown in table 1.
1.3 results of the experiment
A multi-factor analysis of variance module of statistical software SPSS is used for data analysis, and P <0.05 indicates that the difference has statistical significance.
TABLE 1 influence of Chinese medicinal composition on Adriamycin induced chronic nephritis rat urine protein
Figure BDA0001563105740000091
Comparison with model groups: p <0.05, P < 0.01.
Table 1 the experimental results show that the 24-hour urine protein capacity of the model group rats is significantly increased for the normal group and gradually increased as the experiment progresses, indicating that chronic nephritis of the model group rats is progressively increased as the experiment progresses. Although the 24-hour urine protein amounts of the rats in the example 1 group and the comparative examples 1 to 3 were approximately equivalent to those in the model group on the first day of administration, the 24-hour urine protein amounts of the rats in the example 1 group on the 7 th day of administration were significantly decreased relative to those in the model group, and the 24-hour urine protein amounts of the rats in the example 1 group were approximately equivalent to those in the normal group on the 21 st day of administration, which demonstrates that the Chinese medicinal composition in example 1 of the present application has an excellent chronic nephritis treatment effect and can rapidly correct the proteinuria of the rats with chronic nephritis.
The 24-hour urine protein amount of the traditional Chinese medicine composition in the group of the comparative example 1 on the 7 th day of administration is reduced to a certain extent relative to the 24-hour urine protein amount on the first day of administration, so that the traditional Chinese medicine composition in the group of the comparative example 1 also has a certain effect of reducing the urine protein amount of rats with chronic nephritis, but the 24-hour urine protein amount of the rats in the group of the comparative example 1 shows a gradual increase trend along with the experimental dosage form, which indicates that the traditional Chinese medicine composition in the group of the comparative example 1 can only delay the deterioration of the chronic nephritis.
Comparative example 2 the traditional Chinese medicine composition of the group of the traditional Chinese medicine composition of the present application example 1 only replaced prepared rehmannia root with epimedium herb, and tortoise-plastron glue for nourishing yin and tonifying kidney was removed. The 24-hour urine protein amount of the rats in the comparative example 2 is reduced to a certain extent on the 7 th day, the 14 th day and the 21 st day compared with that of the model group, but the reduction amplitude is obviously reduced, and the 24-hour urine protein amount of the rats with chronic nephritis still gradually increases along with the experiment, which shows that the traditional Chinese medicine composition in the comparative example 2 can only play a role in delaying the deterioration of the chronic nephritis of the rats after the prepared rehmannia roots are replaced by the epimedium herb and the tortoise-plastron glue for nourishing yin and tonifying the kidney is removed.
Compared with the traditional Chinese medicine composition in the group of the embodiment 1, the traditional Chinese medicine composition in the group of the comparative example 3 reduces the dosage of kidney-tonifying medicines, the 24-hour urine protein amount of a chronic nephritis rat on the 7 th day of administration of the traditional Chinese medicine composition in the group of the comparative example 3 is approximately equivalent to that of a model group, the 24 th day of administration of the traditional Chinese medicine composition in the group of the comparative example 3 is reduced to a certain extent relative to that of the model group, and the 24 th day of administration of the traditional Chinese medicine composition in the group of the comparative example 3 is obviously reduced relative to that of the model group, so that the traditional Chinese medicine composition in the group of the comparative example 3 also has the effect of treating the.
Effect example 2: clinical treatment effect of traditional Chinese medicine composition on chronic glomerulonephritis
2.1 test subjects
138 chronic nephritis patients aged 28-64 years, 97 of the men and 41 of the women were randomized into two groups, namely example 1 and comparative example 3, and 69 of the groups.
2.2 Experimental drugs
Example 1 group of Chinese medicinal tablets, comparative example 3 group of Chinese medicinal tablets.
2.3 Experimental methods
The patients in the group of the example 1 and the group of the comparative example 3 take the traditional Chinese medicine tablets in the group of the example 1 and the traditional Chinese medicine tablets in the group of the comparative example 3 respectively, 4 tablets are taken each time, twice a day and continuously taken for 30 days, the number of cured, effective and ineffective cases of the patients in each group is observed, the effective rate is calculated, and the specific experimental result is shown in table 2, wherein: effective rate (cured cases + effective cases)/total cases x 100%.
2.4 diagnostic criteria
And (3) curing: renal essential hypertension completely disappeared, proteinuria was continuously negative, urine red blood cells were continuously negative, and 24-hour urine protein amount was <200 mg;
the method has the following advantages: the renal essential hypertension is basically relieved, the urine red blood cells are normal, and compared with the urine protein amount which is reduced by 50% in 24 hours before the medicine is taken;
the effect is shown: the renal parenchymal hypertension is improved, the urine red blood cells are reduced, and compared with the urine red blood cells before the medicine is taken, the urine protein amount is not increased within 24 hours;
and (4) invalidation: renal parenchymal hypertension worsens, urinary red blood cells and 24 hours urine protein levels gradually increase.
2.5 results of the experiment
TABLE 2 clinical treatment effect of Chinese medicinal composition for chronic glomerulonephritis
Group of Number of examples Cure of disease Is effective Show effect Invalidation High efficiency
EXAMPLE 1 group 69 58 10 1 0 98.55％
Comparative example 3 group 69 22 34 8 5 81.16％
The experimental results in table 2 show that the traditional Chinese medicine tablets of the group 1 of the invention can effectively treat chronic glomerulonephritis after being taken for 30 days, the effective rate reaches 98.55%, and the traditional Chinese medicine tablets are obviously better than the traditional Chinese medicine tablets of the group 3 of the comparative examples which also show the treatment effect in the rat chronic nephritis experiment.
The foregoing describes preferred embodiments of the present invention, but is not intended to limit the invention thereto. Modifications and variations of the embodiments disclosed herein may be made by those skilled in the art without departing from the scope and spirit of the invention.

Claims (1)

1. A traditional Chinese medicine composition for treating chronic glomerulonephritis is characterized by being prepared from the following raw material medicines: 54g of prepared rehmannia root, 36g of Chinese yam, 36g of medlar, 24g of cornus, 24g of dodder, 18g of tortoise-plastron glue, 18g of deerhorn glue, 36g of polyporus umbellatus, 36g of tuckahoe, 18g of radix bupleuri, 24g of bighead atractylodes rhizome, 12g of cassia twig, 12g of cicada slough, 27g of divaricate saposhnikovia root, 24g of lalang grass rhizome and 24g of radix achyranthis bidentatae, and the preparation method comprises the following steps:
(1) preparing materials: weighing the raw materials according to a formula;
(2) pretreatment: pulverizing radix rehmanniae Preparata, rhizoma Dioscoreae, fructus Lycii, Corni fructus, semen Cuscutae, Polyporus, Poria, bupleuri radix, Atractylodis rhizoma, ramulus Cinnamomi, periostracum Cicadae, radix Saposhnikoviae, rhizoma Imperatae, and Achyranthis radix into coarse powder to obtain powder 1; crushing the tortoise-plastron glue and the antler glue according to the formula amount, and sieving the crushed tortoise-plastron glue and the antler glue by a 100-mesh sieve to obtain powder 2 for later use;
(3) ethanol extraction: adding 4 times of 80% ethanol into the powder 1, extracting for three times, 2 hours for the first time, 1 hour for the second time and the third time respectively, combining the extracting solutions, recovering the ethanol, and concentrating to obtain an extract with the relative density of 1.15-1.25 at 50 ℃;
(4) mixing and preparing: adding the powder 2 into the extract obtained in the step (3), adding starch slurry to prepare a soft material, sieving with a 14-16 mesh sieve, drying, sieving the obtained dry granules with a 14 mesh sieve, adding a proper amount of magnesium stearate, tabletting, and coating the obtained tablets with a film coat to obtain the tablet.
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