CN108186718A - A kind of gynaecology's spray prevented and inhibit HPV viruse - Google Patents
A kind of gynaecology's spray prevented and inhibit HPV viruse Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A61K36/06—Fungi, e.g. yeasts
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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Abstract
The invention discloses a kind of gynaecology's spray prevented and inhibit HPV viruse, including Sodium Hyaluronate, Radix Arnebiae extract, sophora alopecuroides extract, Honegsukle flower P.E, tuckahoe extracts, Astragalus Root P.E, shrubby sophora extract, mannitol, carbomer, triethanolamine and water.A kind of gynaecology's spray prevented and inhibit HPV viruse proposed by the present invention, non-stimulated to vagina including various plants extract, safety is without side-effects；Sodium Hyaluronate in the spray carry antiviral, antimicrobial component can rapid skin permeation, protect mucosa cells not by virus infraction；And quick repairing skin tissue, improve Wound healing power of regeneration；Various plants extract in the spray also is able to improve immunity of organisms, can play good antiviral effect.The experiment proved that gynaecology's spray produced by the present invention is 93.2% for the effective percentage of low dangerous type HPV infection；Effective percentage for high-risk type HPV infection is 89.3%.
Description
Technical field
The present invention relates to daily chemical product technical field more particularly to a kind of gynaecology's sprays prevented and inhibit HPV viruse.
Background technology
Human papillomavirus (Human Papillomavirus, abbreviation HPV) are a kind of thermophilic epithelial virus, there is height
Specificity.The tumour and wart that known HPV can cause the mankind benign are such as grown in the people on skin and mucous membrane near reproductive organs
Class verruca vulgaris, condyloma acuminatum and the papilloma being grown on mucous membrane.
HPV is a kind of DNA virus, is the general name of one group of virus, and clinically it can be divided into many hypotypes, different Asias
Type can lead to different diseases.Can be low danger by HPV points according to different type HPV and tumorigenic dangerous height
Type and high-risk type.Low danger type HPV includes HPV6,11,42,43,44 etc., often causes the benigns such as external genital organs condyloma
Change includes low lesion (CIN I) in epithelium of cervix uteri.High-risk type HPV include HPV16,18,31,33,35,39,45,51,52,
56th, 58,59,68 etc., it is related to the generation of cervical carcinoma and epithelium of cervix uteri inner height lesion (CIN II/III).
The most common types of reproductive tract infection HPV are 6,11,16,18 types, wherein, 6 and 11 types of HPV often infect vulva,
The positions such as anus, vagina；It is and cervical cancer tissues sample the study found that HPV16 and 18 types are infected and led from countries in the world
The tumour of cause is the most universal.
Have currently for the treatment technology of gynecological disease caused by HPV viruse：Injection intramuscular injection, oral drugs, operation
Deng these methods are bigger to the side effect of human body；Drug therapy also mainly by vagina administration, commonly uses vagina administration system
The dosage form of agent mainly has suppository, spray agent, effervescent tablet, vaginal tablets, lotion, capsule, film etc., but these dosage forms are more or less
There are some defects, influence drug and play a role.
Invention content
Technical problems based on background technology, the present invention, which proposes, provides a kind of woman prevented and inhibit HPV viruse
Section's spray has good inhibiting effect to HPV viruse.
A kind of gynaecology's spray prevented and inhibit HPV viruse, including following component in parts by weight：Sodium Hyaluronate
0.3-0.7 parts, 10-20 parts of Radix Arnebiae extract, 5-15 parts of sophora alopecuroides extract, 2-8 parts of Honegsukle flower P.E, 2-5 parts of mannitol,
1.0-2.0 parts of carbomer, 0.5-1.0 parts of triethanolamine, 50-90 parts of water.
Preferably, the component of following parts by weight meter is further included：5-10 parts of tuckahoe extracts.
Preferably, the component of following parts by weight meter is further included：5-10 parts of Astragalus Root P.E.
Preferably, the component of following parts by weight meter is further included：2-7 parts of shrubby sophora extract.
Preferably, including following component in parts by weight：0.6 part of Sodium Hyaluronate, 15 parts of Radix Arnebiae extract, bitter beans
10 parts of seed extract, 5 parts of Honegsukle flower P.E, 8 parts of tuckahoe extracts, 8 parts of Astragalus Root P.E, 5 parts of shrubby sophora extract, mannitol
3 parts, 1.5 parts of carbomer, 0.8 part of triethanolamine, 60 parts of water.
A kind of preparation method for the gynaecology's spray for preventing and inhibiting HPV viruse, method and step are as follows：
S1：It adds water in emulsifying pot and is warming up to 90-95 DEG C, keep the temperature 30min, add in mannitol, carbomer, stirring
After being uniformly dissolved, it is cooled to 45-50 DEG C；
S2：Plant extracts and Sodium Hyaluronate are added in into emulsification pot, after stirring and dissolving is uniform, are cooled to 45-50 DEG C；
S3：Add in triethanolamine, stir 30min, until solution substantially uniformity to get.
The plant extracts that the present invention uses is nanometer grade powder, can improve its bioavailability；It is proposed by the present invention
A kind of gynaecology's spray is applied to prevent and inhibit HPV viruse.
The effect of each component：
Sodium-salt form of the Sodium Hyaluronate for hyaluronic acid, the hyaluronic acid ingredient containing large, medium and small different molecular weight；
Macromolecular hyaluronic acid forms one layer of ventilative film in skin surface, and therapentic part is applied.Make skin smooth wet
Bacterium can be killed while profit and obstructs the intrusion of external dust and ultraviolet light, protect the skin from encroaching on；Small molecular is transparent
The rapid skin permeation of matter acid drug-carrying makes moisture enter cell interval, protein is promoted to combine, the cell generation brought into normal play
Cytothesis is accelerated in the effect of thanking.
Asian puccoon be it is a kind of there is clearing heat and cooling blood, the Chinese medicine of promoting eruption detoxicating functions containing alkannin and its spreads out in extract
The Multiple components such as biology, polysaccharide, viruses a variety of to human papilloma virus, influenza virus etc. have good inhibiting effect, and have
The fungistatic effect of wide spectrum.Some researches show that：The mechanism that Asian puccoon treats condyloma acuminatum in vivo may be by the influence of certain approach
The expression of survivin promotes infection cell apoptosis, while inhibits the hyperplasia of wart supply vessels, cuts off the nutrition of wart
Source, and then remove virus, wart is made to reduce or even subside
Sophora alopecuroide taste is extremely bitter, cold in nature toxic, has the effects that antibacterial anti-inflammatory, clearing heat and detoxicating, analgesic desinsection.Sophora alopecuroide extracts
Object includes matrine, oxymatrine, sophocarpine, N-Oxysophocarpine, sophoramine, Sophoridine, lehmannine, aloperine, bitter beans
Sub- alkaloid has antiviral, anti-inflammatory and immunosuppressive action, and Banlangen can inhibit a variety of virus breedings, enhance immunological regulation work(
Energy and immunologic enhancement.
Honegsukle flower P.E mainly contains chlorogenic acid and luteolin, has the function of clearing heat and detoxicating, antibacterial anti-inflammatory, moreover it is possible to
Enough improve immunity of organisms.
Polysaccharide and triterpene substance are mainly contained in tuckahoe extracts, has and inhibits the works such as tumour, anti-inflammatory, adjusting immunity
With the sugar has the cytotoxicity of enhancing macrophage and T lymphocytes, moreover it is possible to enhance the immune response of cell and activate machine
For body to the immune surveillance system of tumour, mechanism is related with activating complement；In addition pachymaran can be between inducement interferon, between playing
Connect the effect of antiviral.
Astragalus Root P.E mainly contains saponin(e, flavones, polysaccharide and amino acid etc., and Radix Astragali is to the antibody tormation of normal body
Function is obviously promoted effect.Radix Astragali is in humoral immunity, the phagocytic activity that enhances mononuclear macrophage, to body cell, kill naturally
Hinder the various aspects such as cell release immunologic active material, inducement interferon, interleukins and show a variety of physiological activity.Its is disease-resistant
One of principle of poison may be to improve the ability of patient's leucocyte inducement interferon, promotes the phagocytic function of macrophage, can promote
Into B cell proliferation and inhibit complement activity.
Contain matrine, oxymatrine, ammothamnine, N-Methylcytisine, Anagyrine in shrubby sophora extract
Deng；To matrine, a large amount of pharmacology and clinical research are found in recent years, with antiviral, anti-fibrosis, anti-inflammatory, antitumor etc.
Effect；Central nervous system has calm, analgesia, antipyretic, cooling effect；To skin disease such as allergic dermatitis, eczema and
Gynaecological disease etc. is significant in efficacy.
Application method：It is quiet to lie three minutes at push-in vagina discomfort produced by the present invention after cleaning vulva.
Compared with prior art, the device have the advantages that being：
A kind of gynaecology's spray prevented and inhibit HPV viruse proposed by the present invention, including various plants extract, to vagina
Non-stimulated, safety is without side-effects；Sodium Hyaluronate in the spray carry antiviral, antimicrobial component can rapid skin permeation, protect
Protect mucous membrane cell is not by virus infraction；And quick repairing skin tissue, improve Wound healing power of regeneration；It is a variety of in the spray
Plant extracts also is able to improve immunity of organisms, can play good antiviral effect.It is the experiment proved that produced by the present invention
Gynaecology's spray is 93.2% for the effective percentage of low dangerous type HPV infection；Effective percentage for high-risk type HPV infection is
89.3%.
Specific embodiment
The present invention is made with reference to specific embodiment further to explain.
Embodiment 1
A kind of gynaecology's spray prevented and inhibit HPV viruse, including following component in parts by weight：Sodium Hyaluronate
0.3 part, 10 parts of Radix Arnebiae extract, 5 parts of sophora alopecuroides extract, 2 parts of Honegsukle flower P.E, 5 parts of tuckahoe extracts, Astragalus Root P.E
5 parts, 2 parts of shrubby sophora extract, 2 parts of mannitol, 1.0 parts of carbomer, 0.5 part of triethanolamine, 50 parts of water.
A kind of preparation method for the gynaecology's spray for preventing and inhibiting HPV viruse, method and step are as follows：S1：It adds water to
90 DEG C are warming up in matter emulsification pot, 30min is kept the temperature, adds in mannitol, carbomer, after stirring and dissolving is uniform, be cooled to 45 DEG C；
S2：Plant extracts and Sodium Hyaluronate are added in into emulsification pot, after stirring and dissolving is uniform, are cooled to 45 DEG C；
S3：Add in triethanolamine, stir 30min, until solution substantially uniformity to get.
Embodiment 2
A kind of gynaecology's spray prevented and inhibit HPV viruse, including following component in parts by weight：Sodium Hyaluronate
0.7 part, 20 parts of Radix Arnebiae extract, 15 parts of sophora alopecuroides extract, 8 parts of Honegsukle flower P.E, 10 parts of tuckahoe extracts, astragalus extraction
10 parts of object, 7 parts of shrubby sophora extract, 5 parts of mannitol, 2.0 parts of carbomer, 1.0 parts of triethanolamine, 90 parts of water.
A kind of preparation method for the gynaecology's spray for preventing and inhibiting HPV viruse, method and step are as follows：S1：It adds water to
95 DEG C are warming up in matter emulsification pot, 30min is kept the temperature, adds in mannitol, carbomer, after stirring and dissolving is uniform, be cooled to 50 DEG C；
S2：Plant extracts and Sodium Hyaluronate are added in into emulsification pot, after stirring and dissolving is uniform, are cooled to 50 DEG C；
S3：Add in triethanolamine, stir 30min, until solution substantially uniformity to get.
Embodiment 3
A kind of gynaecology's spray prevented and inhibit HPV viruse, including following component in parts by weight：Sodium Hyaluronate
0.6 part, 15 parts of Radix Arnebiae extract, 10 parts of sophora alopecuroides extract, 5 parts of Honegsukle flower P.E, 8 parts of tuckahoe extracts, astragalus extraction
8 parts of object, 5 parts of shrubby sophora extract, 3 parts of mannitol, 1.5 parts of carbomer, 0.8 part of triethanolamine, 60 parts of water.
A kind of preparation method for the gynaecology's spray for preventing and inhibiting HPV viruse, method and step are as follows：S1：It adds water to
92 DEG C are warming up in matter emulsification pot, 30min is kept the temperature, adds in mannitol, carbomer, after stirring and dissolving is uniform, be cooled to 47 DEG C；
S2：Plant extracts and Sodium Hyaluronate are added in into emulsification pot, after stirring and dissolving is uniform, are cooled to 46 DEG C；
S3：Add in triethanolamine, stir 30min, until solution substantially uniformity to get.
Embodiment 4
A kind of gynaecology's spray prevented and inhibit HPV viruse, including following component in parts by weight：Sodium Hyaluronate
0.5 part, 12 parts of Radix Arnebiae extract, 8 parts of sophora alopecuroides extract, 3 parts of Honegsukle flower P.E, 6 parts of tuckahoe extracts, Astragalus Root P.E
9 parts, 4 parts of shrubby sophora extract, 3 parts of mannitol, 1.3 parts of carbomer, 0.7 part of triethanolamine, 80 parts of water.
A kind of preparation method for the gynaecology's spray for preventing and inhibiting HPV viruse, method and step are as follows：S1：It adds water to
90-95 DEG C is warming up in matter emulsification pot, 30min is kept the temperature, adds in mannitol, carbomer, after stirring and dissolving is uniform, be cooled to 45-
50℃；
S2：Plant extracts and Sodium Hyaluronate are added in into emulsification pot, after stirring and dissolving is uniform, are cooled to 45-50 DEG C；
S3：Add in triethanolamine, stir 30min, until solution substantially uniformity to get.
Embodiment 5
A kind of gynaecology's spray prevented and inhibit HPV viruse, including following component in parts by weight：Sodium Hyaluronate
0.4 part, 18 parts of Radix Arnebiae extract, 13 parts of sophora alopecuroides extract, 6 parts of Honegsukle flower P.E, 9 parts of tuckahoe extracts, astragalus extraction
7 parts of object, 6 parts of shrubby sophora extract, 4 parts of mannitol, 1.8 parts of carbomer, 0.6 part of triethanolamine, 70 parts of water.
A kind of preparation method for the gynaecology's spray for preventing and inhibiting HPV viruse, method and step are as follows：S1：It adds water to
90-95 DEG C is warming up in matter emulsification pot, 30min is kept the temperature, adds in mannitol, carbomer, after stirring and dissolving is uniform, be cooled to 45-
50℃；
S2：Plant extracts and Sodium Hyaluronate are added in into emulsification pot, after stirring and dissolving is uniform, are cooled to 45-50 DEG C；
S3：Add in triethanolamine, stir 30min, until solution substantially uniformity to get.
First, clinical test
1st, subjects：235 HPV viruse the infecteds, wherein 132 low dangerous type HPV infections, 103 high-risk types
HPV infection.
2nd, the age：
In (1) 132 low dangerous type HPV infection patient：Minimal ages 17 years old, max age 52 years old；
In (2) 103 high-risk type HPV infection patients：Minimal ages 21 years old, max age 46 years old.
3rd, the course of disease is distributed：
In (1) 132 low dangerous type HPV infection patient：It is most 1 month short, longest 48 months；
In (2) 103 high-risk type HPV infection patients：It is most 2 months short, longest 26 months.
4th, observation and therapy：Gynaecology's spray produced by the present invention one time a day, using preceding cleaning private parts, takes this product one
Branch removes propeller block, propeller is put into intravaginal (3-5cm depths), liquid is disposably injected and guides to depths, takes out
Propeller abandons it.Low danger type HPV infection patient uses further consultation after 2 months；After high-risk type HPV infection patient uses 3 months
Further consultation.
5th, criterion：
(1) it is effective：HPV turns out cloudy.
(2) in vain, HPV does not turn out cloudy.
6th, treatment results：It is shown in Table 1.
1 treatment results of table
| Group | Number | It is effective | In vain | Total effective rate |
| Low danger type | 132 | 123 | 9 | 93.2% |
| High-risk type | 103 | 92 | 11 | 89.3% |
Table 1 shows：Gynaecology's spray produced by the present invention is 93.2% for the effective percentage of low dangerous type HPV infection；For
The effective percentage of high-risk type HPV infection is 89.3%.
2nd, model case
1st, Ms Zhang, 36 years old, positive+11 types of HPV infection 6 types of low danger were positive, treated by means such as interferon, operations
Afterwards, it recurs repeatedly；Using gynaecology's spray produced by the present invention, wart is obviously reduced after 7 days, and HPV switchs to feminine gender after 1 month.
2nd, Mrs Zhao, 28 years old, low cervical erosion, detection high-risk 16 type of HPV viruse was positive, and use is produced by the present invention
Gynaecology's spray, after 2 half a months, cervical erosion is almost recovered, and HPV switchs to feminine gender.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (7)
1. a kind of gynaecology's spray prevented and inhibit HPV viruse, which is characterized in that including following component in parts by weight：
It is 0.3-0.7 parts of Sodium Hyaluronate, 10-20 parts of Radix Arnebiae extract, 5-15 parts of sophora alopecuroides extract, 2-8 parts of Honegsukle flower P.E, sweet
Reveal 2-5 parts of alcohol, 1.0-2.0 parts of carbomer, 0.5-1.0 parts of triethanolamine, 50-90 parts of water.
2. it is according to claim 1 it is a kind of prevent and inhibition HPV viruse gynaecology's spray, which is characterized in that further include as
The component of lower parts by weight meter：5-10 parts of tuckahoe extracts.
3. it is according to claim 2 it is a kind of prevent and inhibition HPV viruse gynaecology's spray, which is characterized in that further include as
The component of lower parts by weight meter：5-10 parts of Astragalus Root P.E.
4. it is according to claim 3 it is a kind of prevent and inhibition HPV viruse gynaecology's spray, which is characterized in that further include as
The component of lower parts by weight meter：2-7 parts of shrubby sophora extract.
5. it is according to claim 4 it is a kind of prevent and inhibition HPV viruse gynaecology's spray, which is characterized in that including according to
The following component of parts by weight meter：0.6 part of Sodium Hyaluronate, 15 parts of Radix Arnebiae extract, 10 parts of sophora alopecuroides extract, honeysuckle extraction
5 parts of object, 8 parts of tuckahoe extracts, 8 parts of Astragalus Root P.E, 5 parts of shrubby sophora extract, 3 parts of mannitol, 1.5 parts of carbomer, three ethyl alcohol
0.8 part of amine, 60 parts of water.
6. a kind of preparation method of gynaecology's spray for preventing and inhibiting HPV viruse according to claim 5, feature exist
In method and step is as follows：
S1：It adds water in emulsifying pot and is warming up to 90-95 DEG C, keep the temperature 30min, add in mannitol, carbomer, stirring and dissolving
After uniformly, it is cooled to 45-50 DEG C；
S2：Plant extracts and Sodium Hyaluronate are added in into emulsification pot, after stirring and dissolving is uniform, are cooled to 45-50 DEG C；
S3：Triethanolamine is added in, 30min is stirred, until solution substantially uniformity is to get spray.
7. claim 1-5 any one of them composition is applied to prevent and inhibit HPV viruse.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109172732A (en) * | 2018-11-08 | 2019-01-11 | 北京美则美科技有限公司 | A kind of Chinese medicine composition and the preparation method and application thereof of anti-HPV |
| CN110201150A (en) * | 2019-07-12 | 2019-09-06 | 广州莎蔓生物科技有限公司 | A kind of drug increasing the anti-HPV of human body cell activity |
| CN112402506A (en) * | 2019-08-22 | 2021-02-26 | 张爱华 | Traditional Chinese medicine composition for inhibiting HPV virus and/or treating cervical cancer precancerous lesion |
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