CN107961265A - A kind of gynecological gel prevented and suppress HPV viruse - Google Patents
A kind of gynecological gel prevented and suppress HPV viruse Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
The invention discloses a kind of gynecological gel prevented and suppress HPV viruse, including Sodium Hyaluronate, sophora alopecuroides extract, Folium Artemisiae Argyi extract, Flos Chrysanthemi Indici extract, isatis root extract, Astragalus Root P.E, coptis extract, mannitol, carbomer, triethanolamine and water.A kind of gynecological gel prevented and suppress HPV viruse proposed by the present invention, including various plants extract, non-stimulated to vagina, safety is without side-effects；Sodium Hyaluronate in the gel carry antiviral, antimicrobial component can rapid skin permeation, protection mucosa cells are from virus infraction；And quick repairing skin tissue, improve Wound healing power of regeneration；Various plants extract in the gel can also improve immunity of organisms, can play good antiviral effect.It the experiment proved that, gynecological gel produced by the present invention is 91.1% for the effective percentage of low dangerous type HPV infection；Effective percentage for high-risk type HPV infection is 86.1%.
Description
Technical field
The present invention relates to daily chemical product technical field, more particularly to a kind of gynecological gel prevented and suppress HPV viruse.
Background technology
Human papillomavirus (Human Papillomavirus, abbreviation HPV) are a kind of thermophilic epithelial virus, there is height
Specificity.Known HPV can cause the benign tumour of the mankind and wart, such as be grown in people of the reproductive organs nearby on skin and mucous membrane
Class verruca vulgaris, condyloma acuminatum and the papilloma being grown on mucous membrane.
HPV is a kind of DNA virus, is the general name of one group of virus, and clinically it can be divided into many hypotypes, different Asias
Type can cause different diseases.Can be low danger by HPV points according to different type HPV and tumorigenic dangerous height
Type and high-risk type.Low danger type HPV includes HPV6,11,42,43,44 etc., often causes the benigns such as external genital organs condyloma
Change includes low lesion (CIN I) in epithelium of cervix uteri.High-risk type HPV include HPV16,18,31,33,35,39,45,51,52,
56th, 58,59,68 etc., it is related to the generation of cervical carcinoma and epithelium of cervix uteri inner height lesion (CIN II/III).
The most common types of reproductive tract infection HPV are 6,11,16,18 types, wherein, 6 and 11 types of HPV often infect vulva,
The positions such as anus, vagina；And the research of the cervical cancer tissues sample from countries in the world is found, HPV16 and 18 types are infected and led
The tumour of cause is the most universal.
Have currently for the treatment technology of gynecological disease caused by HPV viruse：Injection intramuscular injection, oral drugs, operation
Deng side effect of these methods to human body is bigger；Drug therapy also mainly by vagina administration, commonly uses vagina administration system
The formulation of agent mainly has suppository, gelling agent, effervescent tablet, vaginal tablets, lotion, capsule, film etc., but these formulations are more or less
There are some defects, influence medicine and play a role.
The content of the invention
Based on technical problem existing for background technology, the present invention, which proposes, provides a kind of woman prevented and suppress HPV viruse
Section's gel, has good inhibitory action to HPV viruse.
A kind of gynecological gel prevented and suppress HPV viruse, including following component in parts by weight：Sodium Hyaluronate
0.2-0.5 parts, 10-15 parts of sophora alopecuroides extract, 5-10 parts of Folium Artemisiae Argyi extract, 2-7 parts of Flos Chrysanthemi Indici extract, 2-5 parts of mannitol,
0.5-1.5 parts of carbomer, 0.4-0.8 parts of triethanolamine, 40-70 parts of water.
Preferably, the component of following parts by weight meter is further included：2-7 parts of isatis root extract.
Preferably, the component of following parts by weight meter is further included：2-7 parts of Astragalus Root P.E.
Preferably, the component of following parts by weight meter is further included：5-10 parts of coptis extract.
Preferably, including in parts by weight following component：0.3 part of Sodium Hyaluronate, 12 parts of sophora alopecuroides extract, Chinese mugwort
7 parts of leaf extract, 5 parts of Flos Chrysanthemi Indici extract, 5 parts of isatis root extract, 5 parts of Astragalus Root P.E, 8 parts of coptis extract, sweet dew
3 parts of alcohol, 1.0 parts of carbomer, 0.6 part of triethanolamine, 60 parts of water.
A kind of preparation method for the gynecological gel for preventing and suppressing HPV viruse, method and step are as follows：
S1：Add water in emulsifying pot and be warming up to 90-95 DEG C, keep the temperature 30min, add mannitol, carbomer, stirring
After being uniformly dissolved, 45-50 DEG C is cooled to；
S2：Plant extracts and Sodium Hyaluronate are added into emulsification pot, after stirring and dissolving is uniform, are cooled to 45-50 DEG C；
S3：Triethanolamine is added, 30min is stirred, to solution substantially uniformity；To obtain the final product.
The plant extracts that the present invention uses is nanometer grade powder, can improve its bioavailability；It is proposed by the present invention
A kind of gynecological gel is applied to prevent and suppress HPV viruse.
The effect of each component：
Sodium Hyaluronate is the sodium-salt form of hyaluronic acid, the hyaluronic acid component containing large, medium and small different molecular weight；
Macromolecular hyaluronic acid forms one layer of ventilative film in skin surface, is applied for therapentic part.Make skin smooth wet
Bacterium can be killed while profit and obstructs the intrusion of external dust and ultraviolet, protects the skin from encroaching on；Small molecular is transparent
The rapid skin permeation of matter acid drug-carrying, makes moisture enter cell interval, promotes protein to combine, the cell generation brought into normal play
The effect of thanking, accelerates cytothesis.
Sophora alopecuroide taste is extremely bitter, cold in nature poisonous, has the effect such as antibacterial anti-inflammatory, clearing heat and detoxicating, analgesic desinsection.Sophora alopecuroide extracts
Thing includes matrine, oxymatrine, sophocarpine, N-Oxysophocarpine, sophoramine, Sophoridine, lehmannine, aloperine, bitter beans
Sub- alkaloid has antiviral, anti-inflammatory and immunosuppressive action, and Banlangen can suppress a variety of virus breedings, strengthen immunological regulation work(
Energy and immunologic enhancement.
Folium Artemisiae Argyi extract includes terpinenol -4, β-carypohyllene, artemisol, linalool, camphor, borneol, cineole, Chinese celery
Alkene, Cadinene, thujanol etc..Folium artemisiae argyi in vitro to bacillus anthracis, Alpha-hemolytic streptococcus, B- Streptococcus hemolyticus, corynebacterium diphtheriae,
Bacillus pseudodiphthericus, lung diplococcoid, staphylococcus aureus, Staphylococcus citreus, staphylococcus aureus, hay bacillus etc. 10
Kind gram-positive Aeromonas bacteria all has antibacterial action.
Flos Chrysanthemi Indici extract includes ethyl palmitate, laurate, yejuhua lactone, butterflybush flower glucoside, cyanidenon glucose
The red glucoside of glucoside, chrysanthemum, cyanidenon etc., have effects that anti-bacteria and anti-virus, heat clearing and inflammation relieving, anti-oxidant, prevention skin senescence.
Isatis root extract contains indigo, woaded blue glucoside B, uridine, uracil, hypoxanthine, salicylic acid etc..Clinically have
There is the effect of clearing heat and cooling blood, antiviral antibacterial, while immunity, resistance can also be improved.
Astragalus Root P.E mainly contains saponin(e, flavones, polysaccharide and amino acid etc., antibody tormation of the radix astragali to normal body
Function is obviously promoted effect.Radix astragali in humoral immunity, strengthen the phagocytic activity of mononuclear macrophage, to body cell, kill naturally
Hinder the various aspects such as cell release immunologic active material, inducement interferon, interleukins and show a variety of physiological activity.Its is disease-resistant
One of principle of poison is probably to improve the ability of patient's leucocyte inducement interferon, promotes the phagocytic function of macrophage, can promote
Into B cell propagation and suppress complement activity.
Contain the alkaloids such as jamaicin, coptisine, worenine, palm leaf coculine, jateorrhizine in coptis extract,
Still containing obakunone, obakulactone.In vitro test proves, jamaicin to hemolytic streptococcus, meningococcus, Diplococcus pneumopniae,
Comma bacillus, bacillus anthracis and staphylococcus aureus all have stronger bacteriostasis；To shigella dysenteriae, corynebacterium diphtheriae, withered
Straw bacterium, viridans streptococci have inhibitory action；To pneumobacillus, Bordetella pertussis, yersinia pestis, Brucella, lockjaw
Bacillus, Bacillus perfringens, tubercle bacillus etc. are also effective.
Application method：It is quiet to lie three minutes at push-in vagina discomfort produced by the present invention after cleaning vulva.
Compared with prior art, the device have the advantages that being：
A kind of gynecological gel prevented and suppress HPV viruse proposed by the present invention, including various plants extract, to vagina
Non-stimulated, safety is without side-effects；Sodium Hyaluronate in the gel carry antiviral, antimicrobial component can rapid skin permeation, protect
Protect mucous membrane cell is from virus infraction；And quick repairing skin tissue, improve Wound healing power of regeneration；It is a variety of in the gel
Plant extracts can also improve immunity of organisms, can play good antiviral effect.It the experiment proved that, it is produced by the present invention
Gynecological gel is 91.1% for the effective percentage of low dangerous type HPV infection；Effective percentage for high-risk type HPV infection is
86.1%.
Embodiment
The present invention is made with reference to specific embodiment further to explain.
Embodiment 1
A kind of gynecological gel prevented and suppress HPV viruse, including following component in parts by weight：Sodium Hyaluronate
0.2 part, 10 parts of sophora alopecuroides extract, 5 parts of Folium Artemisiae Argyi extract, 2 parts of Flos Chrysanthemi Indici extract, 2 parts of isatis root extract, astragalus extraction
2 parts of thing, 5 parts of coptis extract, 2 parts of mannitol, 0.5 part of carbomer, 0.4 part of triethanolamine, 40 parts of water.
A kind of preparation method for the gynecological gel for preventing and suppressing HPV viruse, method and step are as follows：
S1：Add water in emulsifying pot and be warming up to 90 DEG C, keep the temperature 30min, add mannitol, carbomer, stirring is molten
After solution is uniform, 45 DEG C are cooled to；
S2：Plant extracts and Sodium Hyaluronate are added into emulsification pot, after stirring and dissolving is uniform, are cooled to 50 DEG C；
S3：Triethanolamine is added, 30min is stirred, to solution substantially uniformity；To obtain the final product.
Embodiment 2
A kind of gynecological gel prevented and suppress HPV viruse, including following component in parts by weight：Sodium Hyaluronate
0.5 part, 15 parts of sophora alopecuroides extract, 10 parts of Folium Artemisiae Argyi extract, 7 parts of Flos Chrysanthemi Indici extract, 7 parts of isatis root extract, radix astragali carry
Take 7 parts of thing, 10 parts of coptis extract, 5 parts of mannitol, 1.5 parts of carbomer, 0.8 part of triethanolamine, 70 parts of water.
A kind of preparation method for the gynecological gel for preventing and suppressing HPV viruse, method and step are as follows：
S1：Add water in emulsifying pot and be warming up to 95 DEG C, keep the temperature 30min, add mannitol, carbomer, stirring is molten
After solution is uniform, 50 DEG C are cooled to；
S2：Plant extracts and Sodium Hyaluronate are added into emulsification pot, after stirring and dissolving is uniform, are cooled to 45 DEG C；
S3：Triethanolamine is added, 30min is stirred, to solution substantially uniformity；To obtain the final product.
Embodiment 3
A kind of gynecological gel prevented and suppress HPV viruse, including following component in parts by weight：Sodium Hyaluronate
0.3 part, 12 parts of sophora alopecuroides extract, 7 parts of Folium Artemisiae Argyi extract, 5 parts of Flos Chrysanthemi Indici extract, 5 parts of isatis root extract, astragalus extraction
5 parts of thing, 8 parts of coptis extract, 3 parts of mannitol, 1.0 parts of carbomer, 0.6 part of triethanolamine, 60 parts of water.
A kind of preparation method for the gynecological gel for preventing and suppressing HPV viruse, method and step are as follows：
S1：Add water in emulsifying pot and be warming up to 93 DEG C, keep the temperature 30min, add mannitol, carbomer, stirring is molten
After solution is uniform, 42 DEG C are cooled to；
S2：Plant extracts and Sodium Hyaluronate are added into emulsification pot, after stirring and dissolving is uniform, are cooled to 47 DEG C；
S3：Triethanolamine is added, 30min is stirred, to solution substantially uniformity；To obtain the final product.
Embodiment 4
A kind of gynecological gel prevented and suppress HPV viruse, including following component in parts by weight：Sodium Hyaluronate
0.4 part, 13 parts of sophora alopecuroides extract, 8 parts of Folium Artemisiae Argyi extract, 6 parts of Flos Chrysanthemi Indici extract, 3 parts of isatis root extract, astragalus extraction
6 parts of thing, 7 parts of coptis extract, 4 parts of mannitol, 0.8 part of carbomer, 0.7 part of triethanolamine, 50 parts of water.
A kind of preparation method for the gynecological gel for preventing and suppressing HPV viruse, method and step are as follows：
S1：Add water in emulsifying pot and be warming up to 93 DEG C, keep the temperature 30min, add mannitol, carbomer, stirring is molten
After solution is uniform, 47 DEG C are cooled to；
S2：Plant extracts and Sodium Hyaluronate are added into emulsification pot, after stirring and dissolving is uniform, are cooled to 45 DEG C；
S3：Triethanolamine is added, 30min is stirred, to solution substantially uniformity；To obtain the final product.
Embodiment 5
A kind of gynecological gel prevented and suppress HPV viruse, including following component in parts by weight：Sodium Hyaluronate
0.5 part, 11 parts of sophora alopecuroides extract, 9 parts of Folium Artemisiae Argyi extract, 4 parts of Flos Chrysanthemi Indici extract, 6 parts of isatis root extract, astragalus extraction
3 parts of thing, 9 parts of coptis extract, 3 parts of mannitol, 1.2 parts of carbomer, 0.5 part of triethanolamine, 65 parts of water.
A kind of preparation method for the gynecological gel for preventing and suppressing HPV viruse, method and step are as follows：
S1：Add water in emulsifying pot and be warming up to 94 DEG C, keep the temperature 30min, add mannitol, carbomer, stirring is molten
After solution is uniform, 49 DEG C are cooled to；
S2：Plant extracts and Sodium Hyaluronate are added into emulsification pot, after stirring and dissolving is uniform, are cooled to 48 DEG C；
S3：Triethanolamine is added, 30min is stirred, to solution substantially uniformity；To obtain the final product.
Clinical test
1st, subjects：250 HPV viruse the infecteds, wherein 135 low dangerous type HPV infections, 115 high-risk types
HPV infection.
2nd, the age：
In (1) 135 low dangerous type HPV infection patient：Minimal ages 19 years old, max age 47 years old；
In (2) 115 high-risk type HPV infection patients：Minimal ages 22 years old, max age 46 years old.
3rd, the course of disease is distributed：
In (1) 135 low dangerous type HPV infection patient：It is most 2 months short, it is most 50 months long；
In (2) 115 high-risk type HPV infection patients：It is most 1 month short, it is most 22 months long.
4th, observation and treatment method：Gynecological gel produced by the present invention, one time a day, using preceding cleaning private parts, takes this product one
Branch, removes propeller block, propeller is put into intravaginal (3-5cm depths), liquid is disposably injected and guides to depths, takes out
Propeller abandons it.Further consultation after low danger type HPV infection patient uses 2 months；After high-risk type HPV infection patient uses 3 months
Further consultation.
5th, criterion：
(1) it is effective：HPV turns out cloudy.
(2) invalid, HPV does not turn out cloudy.
6th, treatment results：It is shown in Table 1.
1 treatment results of table
| Group | Number | It is effective | It is invalid | Total effective rate |
| Low danger type | 135 | 123 | 12 | 91.1% |
| High-risk type | 115 | 99 | 16 | 86.1% |
Table 1 shows：Gynecological gel produced by the present invention is 91.1% for the effective percentage of low dangerous type HPV infection；For
The effective percentage of high-risk type HPV infection is 86.1%.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (7)
1. a kind of gynecological gel prevented and suppress HPV viruse, it is characterised in that including following component in parts by weight：
It is 0.2-0.5 parts of Sodium Hyaluronate, 10-15 parts of sophora alopecuroides extract, 5-10 parts of Folium Artemisiae Argyi extract, 2-7 parts of Flos Chrysanthemi Indici extract, sweet
Reveal 2-5 parts of alcohol, 0.5-1.5 parts of carbomer, 0.4-0.8 parts of triethanolamine, 40-70 parts of water.
2. it is according to claim 1 it is a kind of prevent and suppression HPV viruse gynecological gel, it is characterised in that further include as
The component of lower parts by weight meter：2-7 parts of isatis root extract.
3. it is according to claim 2 it is a kind of prevent and suppression HPV viruse gynecological gel, it is characterised in that further include as
The component of lower parts by weight meter：2-7 parts of Astragalus Root P.E.
4. it is according to claim 3 it is a kind of prevent and suppression HPV viruse gynecological gel, it is characterised in that further include as
The component of lower parts by weight meter：5-10 parts of coptis extract.
5. it is according to claim 4 it is a kind of prevent and suppression HPV viruse gynecological gel, it is characterised in that including according to
The following component of parts by weight meter：0.3 part of Sodium Hyaluronate, 12 parts of sophora alopecuroides extract, 7 parts of Folium Artemisiae Argyi extract, wild chrysanthemum extraction
5 parts of thing, 5 parts of isatis root extract, 5 parts of Astragalus Root P.E, 8 parts of coptis extract, 3 parts of mannitol, 1.0 parts of carbomer, three second
0.6 part of hydramine, 60 parts of water.
6. a kind of preparation method of gynecological gel for preventing and suppressing HPV viruse according to claim 5, its feature exist
In method and step is as follows：
S1：Add water in emulsifying pot and be warming up to 90-95 DEG C, keep the temperature 30min, add mannitol, carbomer, stirring and dissolving
After uniformly, 45-50 DEG C is cooled to；
S2：Plant extracts and Sodium Hyaluronate are added into emulsification pot, after stirring and dissolving is uniform, are cooled to 45-50 DEG C；
S3：Triethanolamine is added, 30min is stirred, to solution substantially uniformity；To obtain the final product.
7. claim 1-4 any one of them composition is applied to prevent and suppress HPV viruse.
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Cited By (5)
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| CN110151899A (en) * | 2019-06-28 | 2019-08-23 | 吴江平 | A kind of Chinese medicine draft formula and its fermentation preparation fighting HPV viruse |
| CN110227060A (en) * | 2019-04-29 | 2019-09-13 | 广东旭睿美医疗科技有限公司 | Containing the anti-HPV gel of giant salamander oligosaccharide peptide |
| CN112220739A (en) * | 2020-10-15 | 2021-01-15 | 国润生物科技（深圳）有限公司 | HPV virus inactivation dressing and preparation method thereof |
| CN112402506A (en) * | 2019-08-22 | 2021-02-26 | 张爱华 | Traditional Chinese medicine composition for inhibiting HPV virus and/or treating cervical cancer precancerous lesion |
| CN113440559A (en) * | 2021-06-04 | 2021-09-28 | 高丽莉 | anti-HPV gel and preparation method thereof |
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| CN110227060A (en) * | 2019-04-29 | 2019-09-13 | 广东旭睿美医疗科技有限公司 | Containing the anti-HPV gel of giant salamander oligosaccharide peptide |
| CN110151899A (en) * | 2019-06-28 | 2019-08-23 | 吴江平 | A kind of Chinese medicine draft formula and its fermentation preparation fighting HPV viruse |
| CN112402506A (en) * | 2019-08-22 | 2021-02-26 | 张爱华 | Traditional Chinese medicine composition for inhibiting HPV virus and/or treating cervical cancer precancerous lesion |
| CN112220739A (en) * | 2020-10-15 | 2021-01-15 | 国润生物科技（深圳）有限公司 | HPV virus inactivation dressing and preparation method thereof |
| CN112220739B (en) * | 2020-10-15 | 2023-09-01 | 国润生物科技（深圳）有限公司 | HPV virus inactivation dressing and preparation method thereof |
| CN113440559A (en) * | 2021-06-04 | 2021-09-28 | 高丽莉 | anti-HPV gel and preparation method thereof |
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