CN108186694A - The extracting process of triterpenes components extraction effect in a kind of promotion Antrodia camphorata - Google Patents
The extracting process of triterpenes components extraction effect in a kind of promotion Antrodia camphorata Download PDFInfo
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- CN108186694A CN108186694A CN201810133326.XA CN201810133326A CN108186694A CN 108186694 A CN108186694 A CN 108186694A CN 201810133326 A CN201810133326 A CN 201810133326A CN 108186694 A CN108186694 A CN 108186694A
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- antrodia camphorata
- extracting process
- extraction effect
- chinese medicine
- triterpenes components
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The invention discloses a kind of extracting process for promoting triterpenes components extraction effect in Antrodia camphorata, and Antrodia camphorata is crushed by Universalpulverizer first, is then impregnated with Chinese medicine treatment fluid, finally extracts to obtain extract using ethyl alcohol；The technique of the present invention adds the step of Chinese medicine treatment fluid impregnates on traditional Process ba- sis.Selection glycerine and pollen pini obtain Chinese medicine treatment fluid after being mixed with water, Chinese medicine treatment fluid is reused after sodium chloride immersion, due to the concentration difference of sodium chloride, the sodium chloride in Antrodia camphorata can be constantly precipitated until reaching concentration balance, and the infiltration of glycerine and pollen pini is more conducive to during this；Glycerine is added in be conducive to triterpenoid structure be prevented to be destroyed, so as to which more triterpenes components are precipitated, and the triterpenes of pollen pini and Antrodia camphorata has synergy the protection of triterpenes components in soaking process.
Description
Technical field
The present invention relates to triterpenes components extraction effects in technical field of plant extraction more particularly to a kind of promotion Antrodia camphorata
Extracting process.
Background technology
Antrodia camphorata also known as cinnamomum kanahirai hay mushroom, belong to Aphyllophorales, Polyporaceae, antrodia karst, perennial gill fungus mushroom, and Latin is entitled
Antrodia camphorata are the novel species just delivered by biochemical boundary nineteen ninety.Growth region is TaiWan, China mountain area height above sea level
Between 450-2000 meters of mountain forests, the rotten heartwood inner wall of cinnamomum kanehirai trunk that is only grown in more than the peculiar a century of TaiWan, China, camphor tree
Timber moist surface, because its acquisition is not easy, the social event of illegal mining Antrodia camphorata still when have what is heard.
Antrodia camphorata was the distinctive fungi of TaiWan, China in the past, was only grow in the distinctive cinnamomum kanehirai of TaiWan, China.Wild ox
Antrodia is the insular child care class seeds of TaiWan, China, in the snow mountain hole Cinnamomum kanahirai hay protection zone of big Anxi upstream, gives birth to more than 100 strain oxen
Camphor tree forest.Antrodia camphorata is the unique weeping fungus found in cinnamomum kanehirai, but the parasitic pathogenic of Antrodia camphorata is not strong, therefore Cinnamomum kanahirai hay
Tree is seldom dead, can grow centuries.Wild Cinnamomum kanahirai hay ganoderma lucidum is uniquely rely, and the host to make a living ----TaiWan, China cinnamomum kanehirai is taken a broad view
The whole world, is only grown on the mountain area of 450 to 2000 meters of TaiWan, China height above sea level, and Cinnamomum kanahirai hay ganoderma lucidum is only grow on the rotten inner wall of cinnamomum kanehirai
Middle vacancy or the dark moist surface of the cinnamomum kanehirai fallen of withered volt, quantity is very rare, and the speed of growth is very slow, often
Year only several centimeters of growth thickness.Due to rare numbers, acquisition is not easy, and market price is up to the hundreds thousand of New Taiwan Currencies of every jin, value
It much outmatches on the rare medicinal herbs such as ganoderma lucidum, ginseng, cordyceps sinensis.
The mystery of Cinnamomum kanahirai hay ganoderma lucidum is early to be wide-spread in the aboriginal clan of TaiWan, China mountainous region, in early days by mountainous region aboriginal in
Wild Antrodia camphorata is found unintentionally, realizes that not only spirit and QI cleaning, spirit improve, feeling of fatigue disappears immediately after edible, muscle power
Enhancing is many, successively there are many magical witness is found with clansman, so for many years, Cinnamomum kanahirai hay ganoderma lucidum is considered as mysterious spirit handed down from one's ancestors
Medicine.
Antrodia camphorata is grown on the moist surface of the rotten hollow inside of cinnamomum kanehirai dry rot or the trunk that lodges.Wild Antrodia camphorata is grown
Aged cinnamomum kanehirai, sporophore shape changeableization have plate, clock shape, horse-hof shape or tower-like；Nascent cerise is gradually long to become
It is white, reddish tan, filbert or khaki.Antrodia camphorata gas fragranced is worked hard, is put down.There is wind-dispelling promoting the circulation of qi, change become silted up promoting blood circulation, middle benefit gas
Disappear knot, removing toxicity for detumescence, sedation-analgesia, antibacterial, it is antiviral, antitumor, promoted immunity of organisms the benefits of；For treatment stomach and intestine pain
Bitterly, diarrhea and vomiting, food poisoning, mushroom poisoning, diabetes, alcoholic liver, fatty liver, hepatic sclerosis, liver cancer etc. are even more to have unique work(
Energy.Antrodia camphorata be there are many physiologically active ingredient, such as polysaccharide body, triterpene compound, Sudismase, adenosine, protein
(containing immune protein), vitamin, trace element, nucleic acid, agglutinin, amino acid, solid liquor-saturated tired, cellulose, blood pressure stabilization substance etc..
Using triterpene compound as most especially in the active ingredient of Antrodia camphorata, up to 200 kinds or more, be that other mushrooms can not be compared,
More than 200 kinds of triterpene compound makes Antrodia camphorata have anticancer, liver protection and other effects.Due to antrodia TaiWan, China be considered as it is unique and
Precious medicinal fungi, therefore the wild fungi with high research and commercial value and current TaiWan, China most expensive.
Triterpene compound is various in nature type, widely distributed, resourceful, mostly with free state or into glycosides or into
The form of ester is present in Chinese herbal medicine, nearly all insoluble or be insoluble in water.Especially into 21 century since the nineties in last century
Later, the diversity of three note class chemical combination microbic activities and importance receive the attention of people, become the one of Chemistry for Chinese Traditional Medicine research
A hot fields.Triterpene compound has extensive physiological activity.Pass through the bioactivity and toxicity to three note class compounds
Research, as a result show its with haemolysis, anticancer, anti-inflammatory, antibacterial, it is antiviral, reduce cholesterol, kill mollusk isoreactivity.
Antrodia camphorata be there are many physiologically active ingredient, such as polysaccharide body, triterpene compound, Sudismase, adenosine, egg
White matter (containing immune protein), vitamin, trace element, nucleic acid, agglutinin, amino acid, solid liquor-saturated tired, cellulose, blood pressure stabilization object
Matter etc..Using triterpene compound as most especially in the active ingredient of Antrodia camphorata, up to 200 kinds or more, be that other mushrooms can not phase
Ratio, more than 200 kinds of triterpene compound makes Antrodia camphorata have anticancer, liver protection and other effects.
Existing Antrodia camphorata extracting process is organic solvent extractionprocess, organic with such as alcohols, lipid, alkanes and alkyl halide class etc.
Solvent infiltrates the Antrodia camphorata raw medicinal herbs as extractant, then removes the organic solvent with low temperature distillation, to obtain Antrodia camphorata
Extract, but the triterpenes components total content that this method is obtained by extraction is still to be improved.
Invention content
Technical problems based on background technology, the present invention propose triterpenes components in a kind of promotion Antrodia camphorata and extract
The extracting process of effect.
Technical scheme is as follows：
The extracting process of triterpenes components extraction effect, includes the following steps in a kind of promotion Antrodia camphorata：
A, it after Antrodia camphorata fructification appearance being cleaned up and dried, is crushed by high speed Universal pulverizer, and mistake
Sieve, obtains bacterium powder；
B, bacterium powder is weighed, is put into salt treatment liquid and impregnates 4-8h, is taken out after drying, then 15- is impregnated in Chinese medicine treatment fluid
24h；
C, the bacterium powder after immersion is poured into ethanol solution, carries out microwave oscillation, obtain Antrodia camphorata extract.
Preferably, in the step A, 325-800 mesh sieve is crossed.
The salt treatment liquid is sodium chloride solution.
Preferably, the Chinese medicine treatment fluid, including following component：Glycerine, pollen pini and water.
Preferably, the Chinese medicine treatment fluid includes the ingredient of following weight percent：
Glycerine 0.5-1%
Pollen pini 0.2-0.5%
Water surplus.
Preferably, in the step C, the volume content of ethyl alcohol is 85-98% in ethanol solution.
Preferably, in the step C, the power of microwave oscillation is 8-15kHz, time 20-30min.
Pollen pini contains there are many nutriment, including 22 kinds of amino acid, 14 kinds of vitamins and 30 various trace elements and
A large amount of active protease, core, flavone compound and other active materials.The protein that pollen pini is rich in is mostly with free amine group
The form of acid exists, content be more than milk, 5-7 times of egg；Ascorbic content is higher than fresh fruit and vegetables, is referred to as
The king of natural complex.Pollen pini is taken, can be lessened fatigue in a short time, enhancing muscle power；Constipation disappears, and digestion takes a turn for the better；Skin is thin
It is greasy, it has rosy cheeks；Sleep is steady and sure, is in a cheerful frame of mind；Energetic, memory improves.
The invention has the beneficial effects that：The extraction side for promoting triterpenes components extraction effect in Antrodia camphorata of the present invention
Method is first crushed Antrodia camphorata by Universalpulverizer, is then impregnated with salt treatment liquid and Chinese medicine treatment fluid, finally
It extracts to obtain extract using ethyl alcohol；The technique of the present invention adds the immersion of Chinese medicine treatment fluid on traditional Process ba- sis
Step.Selection glycerine and pollen pini obtain Chinese medicine treatment fluid after being mixed with water, and Chinese medicine treatment fluid is reused after sodium chloride immersion,
Due to the concentration difference of sodium chloride, the sodium chloride in Antrodia camphorata can be constantly precipitated until reaching concentration balance, during this more
Be conducive to the infiltration of glycerine and pollen pini；Glycerine is added in be conducive to prevent triterpene to the protection of triterpenes components in soaking process
Class formation is destroyed, and so as to which more triterpenes components are precipitated, and the triterpenes of pollen pini and Antrodia camphorata has synergy.
Specific embodiment
Embodiment 1：
The extracting process of triterpenes components extraction effect, includes the following steps in a kind of promotion Antrodia camphorata：
A, it after Antrodia camphorata fructification appearance being cleaned up and dried, is crushed by high speed Universal pulverizer, and mistake
Sieve, obtains bacterium powder；
B, bacterium powder is weighed, is put into 4.5% salt treatment liquid and impregnates 5h, is taken out after drying, then impregnated in Chinese medicine treatment fluid
18h；
C, the bacterium powder after immersion is poured into ethanol solution, carries out microwave oscillation, obtain Antrodia camphorata extract.
In the step A, 600 mesh sieve is crossed.
The Chinese medicine treatment fluid includes the ingredient of following weight percent：
Glycerine 0.8%
Pollen pini 0.3%
Water surplus.
In the step C, the volume content of ethyl alcohol is 92% in ethanol solution.
In the step C, the power of microwave oscillation is 12kHz, time 22min.
Embodiment 2：
The extracting process of triterpenes components extraction effect, includes the following steps in a kind of promotion Antrodia camphorata：
A, it after Antrodia camphorata fructification appearance being cleaned up and dried, is crushed by high speed Universal pulverizer, and mistake
Sieve, obtains bacterium powder；
B, bacterium powder is weighed, is put into 3% salt treatment liquid and impregnates 8h, is taken out after drying, then impregnated in Chinese medicine treatment fluid
15h；
C, the bacterium powder after immersion is poured into ethanol solution, carries out microwave oscillation, obtain Antrodia camphorata extract.
In the step A, 800 mesh sieve is crossed.
The Chinese medicine treatment fluid includes the ingredient of following weight percent：
Glycerine 1%
Pollen pini 0.2%
Water surplus.
In the step C, the volume content of ethyl alcohol is 98% in ethanol solution.
In the step C, the power of microwave oscillation is 8kHz, time 30min.
Embodiment 3：
The extracting process of triterpenes components extraction effect, includes the following steps in a kind of promotion Antrodia camphorata：
A, it after Antrodia camphorata fructification appearance being cleaned up and dried, is crushed by high speed Universal pulverizer, and mistake
Sieve, obtains bacterium powder；
B, bacterium powder is weighed, is put into 5% salt treatment liquid and impregnates 4h, is taken out after drying, then impregnated in Chinese medicine treatment fluid
24h；
C, the bacterium powder after immersion is poured into ethanol solution, carries out microwave oscillation, obtain Antrodia camphorata extract.
In the step A, 325 mesh sieve is crossed.
The Chinese medicine treatment fluid includes the ingredient of following weight percent：
Glycerine 0.5%
Pollen pini 0.5%
Water surplus.
In the step C, the volume content of ethyl alcohol is 85% in ethanol solution.
In the step C, the power of microwave oscillation is 15kHz, time 20min.
Comparative example 1
Glycerine in embodiment 1 is removed, remaining proportioning and extracting process are constant.
Comparative example 2
Glycerine in embodiment 1 and pollen pini are removed, remaining proportioning and extracting process are constant.
Below to the extracting process of embodiment 1-3 and comparative example 1-2, extraction comparison is carried out to same Antrodia camphorata fructification and is surveyed
Examination, the obtained mass fraction of total triterpene constituents are as shown in table 1：
Table 1：The mass fraction of the total triterpene constituents of sample
By more than test data it is recognised that after adding in glycerine, triterpenes components extraction effect is well many in Antrodia camphorata.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (6)
1. a kind of extracting process for promoting triterpenes components extraction effect in Antrodia camphorata, which is characterized in that include the following steps：
A, it after Antrodia camphorata fructification appearance being cleaned up and dried, is crushed, and be sieved, obtained by high speed Universal pulverizer
To bacterium powder；
B, bacterium powder is weighed, is put into salt treatment liquid and impregnates 4-8h, is taken out after drying, then 15-24h is impregnated in Chinese medicine treatment fluid；
C, the bacterium powder after immersion is poured into ethanol solution, carries out microwave oscillation, obtain Antrodia camphorata extract.
2. the extracting process of triterpenes components extraction effect in Antrodia camphorata is promoted as described in claim 1, which is characterized in that institute
In the step A stated, 325-800 mesh sieve is crossed.
3. the extracting process of triterpenes components extraction effect in Antrodia camphorata is promoted as described in claim 1, which is characterized in that institute
The salt treatment liquid stated be sodium chloride solution, the Chinese medicine treatment fluid, including following component：Glycerine, pollen pini and water.
4. the extracting process of triterpenes components extraction effect in Antrodia camphorata is promoted as described in claim 1, which is characterized in that institute
The Chinese medicine treatment fluid stated includes the ingredient of following weight percent：
Glycerine 0.5-1%
Pollen pini 0.2-0.5%
Water surplus.
5. the extracting process of triterpenes components extraction effect in Antrodia camphorata is promoted as described in claim 1, which is characterized in that institute
In the step C stated, the volume content of ethyl alcohol is 85-98% in ethanol solution.
6. the extracting process of triterpenes components extraction effect in Antrodia camphorata is promoted as described in claim 1, which is characterized in that institute
In the step C stated, the power of microwave oscillation is 8-15kHz, time 20-30min.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108743627A (en) * | 2018-07-12 | 2018-11-06 | 萃博士（平潭）生物科技有限公司 | A kind of extraction mode effectively improving Antrodia camphorata triterpene polymer content |
| CN109464469A (en) * | 2018-10-19 | 2019-03-15 | 江苏浦金药业有限公司 | A kind of extracting method of the dried venom of toads |
-
2018
- 2018-02-09 CN CN201810133326.XA patent/CN108186694A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108743627A (en) * | 2018-07-12 | 2018-11-06 | 萃博士（平潭）生物科技有限公司 | A kind of extraction mode effectively improving Antrodia camphorata triterpene polymer content |
| CN109464469A (en) * | 2018-10-19 | 2019-03-15 | 江苏浦金药业有限公司 | A kind of extracting method of the dried venom of toads |
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Application publication date: 20180622 |