CN108186445A - A kind of Chinese medicine antibacterial toothpaste of lysozyme - Google Patents
A kind of Chinese medicine antibacterial toothpaste of lysozyme Download PDFInfo
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- CN108186445A CN108186445A CN201810166673.2A CN201810166673A CN108186445A CN 108186445 A CN108186445 A CN 108186445A CN 201810166673 A CN201810166673 A CN 201810166673A CN 108186445 A CN108186445 A CN 108186445A
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- lysozyme
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- toothpaste
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Abstract
The invention discloses a kind of Chinese medicine antibacterial toothpaste of lysozyme, it is characterised in that：Include the component of following parts by weight：0.1 1 parts of 18 parts of safflower, 20 30 parts of calcium phosphate, 12 parts of lanthanum chloride, 12 parts of purple daisy extract, low 0.5 2 parts of silica of defoaming, 27 parts of lysozyme, 0.01 0.04 parts of Chinese violet, 10 20 parts of almond, 2 10 parts of thin cloves and calcium sorbate.Toothpaste disclosed by the invention is light with flavour of a drug, and pulvis refrigerans swell, and the pure and fresh effect to wet one's whistle, strong antibacterial is washed one's face and rinsed one's mouth in good taste.
Description
Technical field
The present invention relates to a kind of toothpaste, it is more particularly related to a kind of Chinese medicine antibacterial toothpaste of lysozyme.
Background technology
Toothpaste is to protect oral hygiene together for cleaning tooth with toothbrush, be that one kind safe to the human body is daily required
Product.
The type of toothpaste is dazzling, is broadly divided into ordinary toothpaste, medicated toothpaste and toothpaste with fluoride three categories.Common
On the basis of toothpaste, add in some have oral health act on drug or anticaries efficacy fluoride, reform into medicated toothpaste and
Toothpaste with fluoride.
With the rapid development of science and technology, toothpaste industry also obtains very big improvement, is on the one hand new rubbing agent, moisturizing
The development and application of agent, thickener and surfactant makes tooth paste product quality constantly upgrade；On the other hand, toothpaste from
The common function development that cleans the teeth is to add drug to become the dental care product of prevention odontopathy, and most prominent is to add fluorine toothpaste, is made
Dental caries incidence greatly reduces.But into the manhood, the incidence of periodontal disease was gradually increasing, and with the age
Increase, its severity is also constantly deepened.Gum, periodontium are protected, seems more urgent for adult.Part Chinese herbal medicine
Toothpaste can really play the role of taking care of one's teeth comprehensively, gum, periodontium.
For example, mica filled polypropylene, it can prevent rapidly bleeding gums, the mouths such as prevention of gingivitis, periodontitis, gingival atrophy
Chamber problem.Certainly, this active constituent for depending on Yunnan Baiyao in toothpaste, can effectively improve gum, periodontium and oral cavity
The blood circulation of mucous membrane improves the supply of periodontium and oral cavity mucous membrane tissue nutrient, enhancing gum, periodontal, tooth and oral cavity
The disease resistance of mucous membrane.
After brushing teeth or gargling, gum is suitably massaged, can enhance epithelium angling, the blood for strengthening gingiva tissue follows
Ring promotes the health of gingiva tissue.Even if toothpaste has so many purposes, but the still toothpaste that people are paid attention to the most is to tooth
Protection and in terms of oral hygiene.Since many people like smoking, so the easy long dental plaque of tooth, influences teeth whitening U.S.
While sight, also damage to oral hygiene.The type of toothpaste is various on the market, and the toothpaste of Chinese herbal medicine is outstanding also with its
Pharmacological action and received by people.But still there is the taste of the uncomfortable Chinese herbal toothpaste of part population.More and more people
Like having fragranced and the good toothpaste of cleaning benefits, especially like the toothpaste with mint flavored.Publication No. CN
101467949, publication date is that the Chinese patent literature of on 07 01st, 2009 discloses a kind of biological product toothpaste, the biology system
A variety of Chinese herbal medicines are made by product toothpaste by containing there are many characterized by medicinal herb components through certain technique.Although Chinese herbal medicine tooth
There is cream heat-clearing to drive phlegm, and the effect of softening and resolving hard mass, eliminating inflammation and expelling toxin, but its Chinese herbal medicine flavour of a drug is heavier, commonly using can cause people
Uncomfortable reaction, in addition, its antibacterial ability and mouthfeel of washing one's face and rinsing one's mouth are all poor.
Invention content
The defects of in order to overcome the above-mentioned prior art, the present invention provide a kind of Chinese medicine antibacterial toothpaste of lysozyme, this hair
Bright disclosed toothpaste is light with flavour of a drug, and pulvis refrigerans swell, and the pure and fresh effect to wet one's whistle, strong antibacterial is washed one's face and rinsed one's mouth in good taste.
In order to achieve the above-mentioned object of the invention, the technical solution adopted by the present invention is as follows：
A kind of Chinese medicine antibacterial toothpaste of lysozyme, it is characterised in that：Include the component of following parts by weight：
1-8 parts of safflower
20-30 parts of calcium phosphate
1-2 parts of lanthanum chloride
1-2 parts of purple daisy extract
Low 0.5-2 parts of silica of defoaming
2-7 parts of lysozyme
0.01-0.04 parts of Chinese violet
10-20 parts of almond
It is cloves 2-10 parts thin
0.1-1 parts of calcium sorbate.
The purple daisy extract is by the way that by purple daisy, 8 times of 60% ethyl alcohol heating and refluxing extraction 3h of amount of addition are filtered, filter
Liquid is concentrated under reduced pressure, and low temperature drying is made.
The low defoaming silica is by adding in 15m into the first reaction kettle3Metabisulfite solution adds 4kg's
Sodium sulfate of polyethenoxy ether of fatty alcohol stirs evenly and is heated to 80 DEG C；With 20m3The flow velocity of/h is added in into the first reaction kettle
15m3Sodium silicate solution, add sulfuric acid solution after one minute, adjust the addition speed of sulfuric acid solution to control reaction process
PH value for 10, continue to add sulfuric acid solution, until reaction end pH value is 3.5, stop addition sulfuric acid solution；Keep first instead
It is 80 DEG C to answer solution temperature in kettle, continues stirring 25 minutes；Carboxymethylcellulose sodium solution is added in into the second reaction kettle, 70
It is stirred 10 minutes at DEG C, then adds sulfuric acid solution, solution ph is adjusted to 6, adds potassium peroxydisulfate and sodium hydrogensulfite, and stir
Uniformly, the sodium carboxymethylcellulose of activation is made；Finally the sodium carboxymethylcellulose of activation is added in the first reaction kettle and is mixed
It stirs evenly, after reacting 6h at 70 DEG C, solids is obtained by filtration, solids dries pulverizing is made.
The mass percent concentration of metabisulfite solution is 10% in first reaction kettle, the quality percentage of sodium silicate solution
Specific concentration is 7%.
The mass percent concentration of carboxymethylcellulose sodium solution is 7% in second reaction kettle, mole of sulfuric acid solution
A concentration of 8mol/L.
The advantageous effects that the present invention is brought are：
It is used as abrasive in toothpaste by defoaming silica low made from ad hoc approach, not only with good friction cleaning
Performance, while there is good foaming agent compatibility, toothpaste is made to have good clean-up performance and abundant foam when scrubbing,
Mouthfeel is scrubbed in raising；Due to low defoaming silica obtained, kernel is inorganic constituents, and shell is organic principle, thus
Rubbing action and water suction thickening power can be had both in toothpaste simultaneously, be keyed between interior nuclear composition and shell by chemistry, because
This has the advantages that structure and performance are stablized；Not only there is medicine by the Chinese medicine antibacterial toothpaste of lysozyme made from special formulation
Flat flavor, pulvis refrigerans swell, the pure and fresh effect to wet one's whistle, and strong antibacterial, wash one's face and rinse one's mouth in good taste.
Specific embodiment
Embodiment 1
A kind of Chinese medicine antibacterial toothpaste of lysozyme includes the component of following parts by weight：
1 part of safflower
20 parts of calcium phosphate
1 part of lanthanum chloride
1 part of purple daisy extract
Low 0.5 part of silica of defoaming
2 parts of lysozyme
0.01 part of Chinese violet
10 parts of almond
Thin 2 parts of cloves
0.1 part of calcium sorbate.
The purple daisy extract is by the way that by purple daisy, 8 times of 60% ethyl alcohol heating and refluxing extraction 3h of amount of addition are filtered, filter
Liquid is concentrated under reduced pressure, and low temperature drying is made.
Embodiment 2
A kind of Chinese medicine antibacterial toothpaste of lysozyme includes the component of following parts by weight：
3 parts of safflower
23 parts of calcium phosphate
1.2 parts of lanthanum chloride
1.2 parts of purple daisy extract
Low 0.6 part of silica of defoaming
4 parts of lysozyme
0.02 part of Chinese violet
15 parts of almond
Thin 5 parts of cloves
0.5 part of calcium sorbate.
The purple daisy extract is by the way that by purple daisy, 8 times of 60% ethyl alcohol heating and refluxing extraction 3h of amount of addition are filtered, filter
Liquid is concentrated under reduced pressure, and low temperature drying is made.
The low defoaming silica is by adding in 15m into the first reaction kettle3Metabisulfite solution adds 4kg's
Sodium sulfate of polyethenoxy ether of fatty alcohol stirs evenly and is heated to 80 DEG C；With 20m3The flow velocity of/h is added in into the first reaction kettle
15m3Sodium silicate solution, add sulfuric acid solution after one minute, adjust the addition speed of sulfuric acid solution to control reaction process
PH value for 10, continue to add sulfuric acid solution, until reaction end pH value is 3.5, stop addition sulfuric acid solution；Keep first instead
It is 80 DEG C to answer solution temperature in kettle, continues stirring 25 minutes；Carboxymethylcellulose sodium solution is added in into the second reaction kettle, 70
It is stirred 10 minutes at DEG C, then adds sulfuric acid solution, solution ph is adjusted to 6, adds potassium peroxydisulfate and sodium hydrogensulfite, and stir
Uniformly, the sodium carboxymethylcellulose of activation is made；Finally the sodium carboxymethylcellulose of activation is added in the first reaction kettle and is mixed
It stirs evenly, after reacting 6h at 70 DEG C, solids is obtained by filtration, solids dries pulverizing is made.
Embodiment 3
A kind of Chinese medicine antibacterial toothpaste of lysozyme includes the component of following parts by weight：
5 parts of safflower
26 parts of calcium phosphate
1.5 parts of lanthanum chloride
1.2 parts of purple daisy extract
Low defoaming silica 1 part
5 parts of lysozyme
0.03 part of Chinese violet
18 parts of almond
Thin 8 parts of cloves
0.8 part of calcium sorbate.
The purple daisy extract is by the way that by purple daisy, 8 times of 60% ethyl alcohol heating and refluxing extraction 3h of amount of addition are filtered, filter
Liquid is concentrated under reduced pressure, and low temperature drying is made.
The low defoaming silica is by adding in 15m into the first reaction kettle3Metabisulfite solution adds 4kg's
Sodium sulfate of polyethenoxy ether of fatty alcohol stirs evenly and is heated to 80 DEG C；With 20m3The flow velocity of/h is added in into the first reaction kettle
15m3Sodium silicate solution, add sulfuric acid solution after one minute, adjust the addition speed of sulfuric acid solution to control reaction process
PH value for 10, continue to add sulfuric acid solution, until reaction end pH value is 3.5, stop addition sulfuric acid solution；Keep first instead
It is 80 DEG C to answer solution temperature in kettle, continues stirring 25 minutes；Carboxymethylcellulose sodium solution is added in into the second reaction kettle, 70
It is stirred 10 minutes at DEG C, then adds sulfuric acid solution, solution ph is adjusted to 6, adds potassium peroxydisulfate and sodium hydrogensulfite, and stir
Uniformly, the sodium carboxymethylcellulose of activation is made；Finally the sodium carboxymethylcellulose of activation is added in the first reaction kettle and is mixed
It stirs evenly, after reacting 6h at 70 DEG C, solids is obtained by filtration, solids dries pulverizing is made.
The mass percent concentration of metabisulfite solution is 10% in first reaction kettle, the quality percentage of sodium silicate solution
Specific concentration is 7%.
Embodiment 4
A kind of Chinese medicine antibacterial toothpaste of lysozyme includes the component of following parts by weight：
8 parts of safflower
30 parts of calcium phosphate
2 parts of lanthanum chloride
2 parts of purple daisy extract
Low 2 parts of silica of defoaming
7 parts of lysozyme
0.04 part of Chinese violet
20 parts of almond
Thin 10 parts of cloves
1 part of calcium sorbate.
The purple daisy extract is by the way that by purple daisy, 8 times of 60% ethyl alcohol heating and refluxing extraction 3h of amount of addition are filtered, filter
Liquid is concentrated under reduced pressure, and low temperature drying is made.
The low defoaming silica is by adding in 15m into the first reaction kettle3Metabisulfite solution adds 4kg's
Sodium sulfate of polyethenoxy ether of fatty alcohol stirs evenly and is heated to 80 DEG C；With 20m3The flow velocity of/h is added in into the first reaction kettle
15m3Sodium silicate solution, add sulfuric acid solution after one minute, adjust the addition speed of sulfuric acid solution to control reaction process
PH value for 10, continue to add sulfuric acid solution, until reaction end pH value is 3.5, stop addition sulfuric acid solution；Keep first instead
It is 80 DEG C to answer solution temperature in kettle, continues stirring 25 minutes；Carboxymethylcellulose sodium solution is added in into the second reaction kettle, 70
It is stirred 10 minutes at DEG C, then adds sulfuric acid solution, solution ph is adjusted to 6, adds potassium peroxydisulfate and sodium hydrogensulfite, and stir
Uniformly, the sodium carboxymethylcellulose of activation is made；Finally the sodium carboxymethylcellulose of activation is added in the first reaction kettle and is mixed
It stirs evenly, after reacting 6h at 70 DEG C, solids is obtained by filtration, solids dries pulverizing is made.
The mass percent concentration of metabisulfite solution is 10% in first reaction kettle, the quality percentage of sodium silicate solution
Specific concentration is 7%.
The mass percent concentration of carboxymethylcellulose sodium solution is 7% in second reaction kettle, mole of sulfuric acid solution
A concentration of 8mol/L.
It is used as abrasive in toothpaste by defoaming silica low made from ad hoc approach, not only with good friction
Clean-up performance, while have good foaming agent compatibility makes toothpaste have good clean-up performance and abundant when scrubbing
Mouthfeel is scrubbed in foam, raising；Due to low defoaming silica obtained, kernel is inorganic constituents, and shell is organic principle, because
And rubbing action and water suction thickening power can be had both simultaneously in toothpaste, connected between interior nuclear composition and shell by chemical bond
It connects, therefore has the advantages that structure and performance are stablized；By the Chinese medicine antibacterial toothpaste of lysozyme made from special formulation not only
Light with flavour of a drug, pulvis refrigerans swell, the pure and fresh effect to wet one's whistle, and strong antibacterial, wash one's face and rinse one's mouth in good taste.
Claims (5)
1. a kind of Chinese medicine antibacterial toothpaste of lysozyme, it is characterised in that：Include the component of following parts by weight：
1-8 parts of safflower
20-30 parts of calcium phosphate
1-2 parts of lanthanum chloride
1-2 parts of purple daisy extract
Low 0.5-2 parts of silica of defoaming
2-7 parts of lysozyme
0.01-0.04 parts of Chinese violet
10-20 parts of almond
It is cloves 2-10 parts thin
0.1-1 parts of calcium sorbate.
2. a kind of Chinese medicine antibacterial toothpaste of lysozyme according to claim 1, it is characterised in that：The purple daisy extract
It is by the way that by purple daisy, 8 times of 60% ethyl alcohol heating and refluxing extraction 3h of amount of addition are filtered, filtrate decompression concentration, low temperature drying is made.
3. a kind of Chinese medicine antibacterial toothpaste of lysozyme according to claim 1, it is characterised in that：The low defoaming titanium dioxide
Silicon is by adding in 15m into the first reaction kettle3Metabisulfite solution adds the sodium sulfate of polyethenoxy ether of fatty alcohol of 4kg, stirs
It mixes uniformly and is heated to 80 DEG C；With 20m3The flow velocity of/h adds in 15m into the first reaction kettle3Sodium silicate solution, after one minute again
Sulfuric acid solution is added in, adjusts the additions speed of sulfuric acid solution to control the pH value of reaction process as 10, continues addition sulfuric acid solution,
Until reaction end pH is 3.5, stop addition sulfuric acid solution；It is 80 DEG C to keep solution temperature in the first reaction kettle, continues to stir
25 minutes；Carboxymethylcellulose sodium solution is added in into the second reaction kettle, is stirred 10 minutes at 70 DEG C, then adds sulfuric acid solution,
Solution ph is adjusted to 6, adds potassium peroxydisulfate and sodium hydrogensulfite, and stir evenly, the carboxymethyl cellulose of activation is made
Sodium；Finally the sodium carboxymethylcellulose of activation is added in the first reaction kettle and is stirred evenly, after reacting 6h at 70 DEG C, is filtered
To solids, solids dries pulverizing is made.
4. a kind of Chinese medicine antibacterial toothpaste of lysozyme according to claim 3, it is characterised in that：In first reaction kettle
The mass percent concentration of metabisulfite solution is 10%, and the mass percent concentration of sodium silicate solution is 7%.
5. a kind of Chinese medicine antibacterial toothpaste of lysozyme according to claim 3, it is characterised in that：In second reaction kettle
The mass percent concentration of carboxymethylcellulose sodium solution is 7%, and the molar concentration of sulfuric acid solution is 8mol/L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810166673.2A CN108186445A (en) | 2018-02-28 | 2018-02-28 | A kind of Chinese medicine antibacterial toothpaste of lysozyme |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810166673.2A CN108186445A (en) | 2018-02-28 | 2018-02-28 | A kind of Chinese medicine antibacterial toothpaste of lysozyme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108186445A true CN108186445A (en) | 2018-06-22 |
Family
ID=62594517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810166673.2A Withdrawn CN108186445A (en) | 2018-02-28 | 2018-02-28 | A kind of Chinese medicine antibacterial toothpaste of lysozyme |
Country Status (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110368327A (en) * | 2019-08-14 | 2019-10-25 | 广州益凡医疗器械有限公司 | A kind of plaque removes gel and preparation method thereof |
-
2018
- 2018-02-28 CN CN201810166673.2A patent/CN108186445A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110368327A (en) * | 2019-08-14 | 2019-10-25 | 广州益凡医疗器械有限公司 | A kind of plaque removes gel and preparation method thereof |
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180622 |
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| WW01 | Invention patent application withdrawn after publication |