CN108185433A - With the health care formula and preparation method and application to relax bowel with soporific function - Google Patents
With the health care formula and preparation method and application to relax bowel with soporific function Download PDFInfo
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- CN108185433A CN108185433A CN201810038626.XA CN201810038626A CN108185433A CN 108185433 A CN108185433 A CN 108185433A CN 201810038626 A CN201810038626 A CN 201810038626A CN 108185433 A CN108185433 A CN 108185433A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/156—Flavoured milk preparations ; Addition of fruits, vegetables, sugars, sugar alcohols or sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/06—Treating tea before extraction; Preparations produced thereby
- A23F3/14—Tea preparations, e.g. using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L13/00—Meat products; Meat meal; Preparation or treatment thereof
- A23L13/40—Meat products; Meat meal; Preparation or treatment thereof containing additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention discloses with the health care formula and preparation method and application to relax bowel with soporific function, belong to field of health care food.The effect of present invention is carried out compatibilities, made each raw material with 0.1 200 parts of 100 parts of flower of Fructus Momordicae, 1 200 parts of Siraitia grosvenorii, 0.1 50 parts of Radix Glycyrrhizae, 0.1 10 parts of Leaves of Glycyrrhiza Uralensis Fisch, 0.1 200 parts of lily, 0.1 200 parts of wild jujube, 0.1 200 parts of spina date seed, 0.1 200 parts of lichee and longan (longan) generates collaboration.Above-mentioned raw materials water and water/ethanol water (5 95%, v/v) extract twice, are concentrated, then are aided with suitable edible raw material and health products are made for carrier.Prepared health products have it is significant relax bowel and soporific function, positive effect is respectively provided with to different degrees of dyspepsia, constipation and insomniac.The present invention uses materials safety and cheap, preparation is simply, without side-effects.
Description
Technical field
The present invention relates to the health care formula and preparation method and application to relax bowel with soporific function, belong to health care food
Product field.
Background technology
Constipation is one of common clinical card, refers to the not normal caused constipation of large intestine conduction, defecation excessive cycle；Or
Period is not grown, but excrement matter is dry and hard, and discharge is difficult；Or excrement matter is not hard, though there is awareness of defecation, just without smooth disease.Constipation is mostly because big
(the text at all times of Zhang Haipeng constipation illnesss caused by many factors such as intestines accumulated heat, the stagnation of the circulation of vital energy, cold solidifying, phlegm stagnation, yang blood and qi virtual loss
Offer research and discussion [D] the Beijing University of Chinese Medicine of academic former stream, 2008.).With social development, the work habit of people,
Life style and dietary structure etc. change therewith.Due to these variations and accompany and the influence of spiritual feelings will that generates,
The aging of social population so that the incidence of the spleen and stomach illness is in rising trend, common disease of the constipation as taste system disease,
Even more widely see morbidity crowd.Foreign data shows that the incidence of constipation is 3% in young man, the middle age artificial 8%, always
Year artificial 20% (Muller-Lissner S.Diagnosis and therapy of constipation [J] .Schweiz
Rundsch Med Prax, 1998,87 (48)：1645-1648.).Beijing area epidemiological survey shows, non-patient crowd
The incidence of constipation is the 6.07% (prevalence of the such as square Xiucai, Lu Sucai, Pan Guozong Beijing areas adult non-patient crowd's defecation
Disease learns investigation Chinese Medical Journals [J] .2001,81 (21)：1287-1290.).Insomnia is common sympton in clinic, it be with
(Zhang Chao, Wang Jingjie, king Lu wait insomnias with constipation type intestines to the related psychogenic sleep-disorder of individual character, mood, negative life events
Irritable syndrome patient sleeps feature and motilin, clinical observation [J] the gastroenterologies of growth hormone release inhibiting hormone and hepatopathy magazine,
2009,18 (8)：735-737.).Insomnia has a significant impact to patient and society.It is difficult that slight insomniac can behave as paying attention to
To concentrate, dysphoria or even the discomfort that body can be caused, such as headache.Severe insomnia person will also bring serious society to ask
Topic, such as the U.S. in 1988 merely because reaching 000,000,000 dollars of 430-56 if the expense of traffic accident caused by insomnia.American National is slept
Barrier study committee report, 199 0 years expenditures for insomnia patient are 15,400,000,000 dollars of (Zhao Zhongxin, Zhang Hongju, Huang Liu
The medicine and its application method progress [J] Chinese Journal of New Drugs and Clinical Remedies of clear insomnias, 2007,26 (11)：851-
856.).It can be seen that insomnia is both medical problem and social concern, great attention both domestic and external should be caused.The a large amount of epidemic diseases in China
It learns investigation to find, chronic insomnia patient is 6-10% in crowd, and the constipation insomniac's ratio that occurs together is up to 70% (Xiao Yan swallow kings
Buxin Pills plus-minus treatment habitual constipation is with clinical observation on the therapeutic effect [J] TCM clinical studies of insomnia, 2013,4 (12)：5-
6；Morin CM,Benca R.Chronic insomnia[J].Lancet,2012,379:1129-1141.).There is population in China
More than 1,300,000,000, with the aging of Chinese society, the ratio and absolute quantity of constipation and insomnia population will all continue to increase, this will
The health and quality of life of patient are seriously affected, and a series of social concern may be caused.Therefore, it treats and improves just
Secret and insomniac illness is particularly important.
The drug for the treatment of constipation at present mainly includes purgatives, dynamics-promoting medicine and succagoga etc., and above-mentioned therapy exists
It clinically has a significant effect, is clinically common method.It but may there is also some defects, such as purgatives long-time service
Body is influenced to liposoluble vitamin and calcium, the absorption of phosphorus, it is also possible to patient's electrolyte imbalance be caused even to seriously affect kidney
The life security of function or diastolic dysfunction, in addition, can not fundamentally solve patient just using above-mentioned therapeutic scheme
Secret problem (Du Pengqiang, Chen Mingyue, Wang Xue wait the medicine present situation of chronic constipations and new development [J] food and drug,
2016,18(4):296-299.)。
Common drug have hypnotic sedative agent (barbiturates, benzene phenodiazine cover class and non-benzene phenodiazine cover class), antidepressants, anti-group
Amine medicine and Chinese medicine etc..Barbiturate has been not used in treatment insomnia since its adverse reaction is more substantially；In recent years benzene phenodiazine is removed from office
Class drug, although it can increase sleeping time, can not improve sleep quality and side effect is more, effect is not enough managed using extensively
Think；Novel non-benzene phenodiazine cover class drug is turned to again at present, for a kind of hypnotic drug.Although now with many treatment insomnias
Drug, but can only generally improve symptom and be difficult will have a sleepless night thoroughly healing (Zhao Zhongxin, Zhang Hongju, the medicine that the clear of Huang stream has a sleepless night
Object and its application method progress [J] Chinese Journal of New Drugs and Clinical Remedies, 2007,26 (11)：851-856.).And it takes for a long time
Side reaction caused by drug allows many patients to fear medication so as to be absorbed in an awkward condition again.It is therefore desirable to further
Excavating potential of the Chinese medicine in terms of sleep is improved, particularly integration of drinking and medicinal herbs Chinese medicine is improving the effect in sleeping.
The flower of Fructus Momordicae of safety, Leaves of Glycyrrhiza Uralensis Fisch and 2017 is eaten for a long time using the regional people such as China Guangxi, Yunnan in the present invention
The integration of drinking and medicinal herbs material development that Nian Wei planning commissions announce it is a kind of with the health care formula to relax bowel with soporific function, and answered
It uses in corresponding health food, it is made to have simultaneously and is relaxed bowel and soporific function.With other drugs with this function and guarantor
Strong condition ratio, key difference of the invention point are：(1) present invention use primary raw material flower of Fructus Momordicae, Siraitia grosvenorii, lily,
Spina date seed, lichee and longan (longan) are clearly distinguishable from other products with corresponding function using Chinese medicine as raw material；(2) it is above-mentioned
Raw material is raw material or civil long-term in the healthy food material catalogue of state food pharmaceuticals administration general bureau of China publication
The raw material of safe edible, it is safe, it can be used for a long time；(3) above-mentioned formulation efficacy is notable, and 1-3 days take effect, and raw material is
It is common raw material, cheap.Understand that the present invention has important medical significance and social effect by features above.
Invention content
The purpose of the invention is to develop to have to relax bowel and the health care formula of soporific function and preparation method and general
It is applied to varieties of food items.Specifically, the present invention provides with flower of Fructus Momordicae, Siraitia grosvenorii, Radix Glycyrrhizae, Leaves of Glycyrrhiza Uralensis Fisch, lily, wild jujube,
Flower of Fructus Momordicae in spina date seed, lichee and longan (longan) adds two or more raw material in other eight kinds of raw materials to be health care
The formula of raw material and by this be formulated based on exploitation with the method that relaxes bowel with soporific function health products.
It is made of with relaxing bowel with the health caring product prescription of soporific function following raw materials according：
(1) formula composition：
100 parts of flower of Fructus Momordicae,
1-200 parts of Siraitia grosvenorii,
0.1-50 parts of Radix Glycyrrhizae,
0.1-10 parts of Leaves of Glycyrrhiza Uralensis Fisch,
0.1-200 parts of lily,
0.1-200 parts of wild jujube,
0.1-200 parts of spina date seed,
0.1-200 parts of lichee,
0.1-200 parts of longan (longan)；
It is added with flower of Fructus Momordicae and states two or more raw material in other eight kinds of raw materials and formed according to aforementioned proportion
Inventive formulation；
The present invention has the preparation method to relax bowel with the health care formula of soporific function, carries out as steps described below：
(2) raw material Radix Glycyrrhizae, spina date seed crush in above-mentioned formula (1), the manual broken shell of Siraitia grosvenorii, lichee and longan (longan),
Arhat shell is continued to employ, and lichee and longan pericarp abandon, and according to ratio mixed raw material in formula (1), adds 5-30 times of raw material weight oneself
Water, 60-100 DEG C is boiled 10-180min, and infusion adds a certain amount of edible alcohol adjusting alcoholic strength to 5- after terminating cooling
95%, room temperature extracts 1-30d after sealing, and leaching liquor filtering and removing slag are concentrated in vacuo to raw mixture weight.
(3) by concentrate in (2) be added to according to a certain percentage alcoholic beverage, fruit-vegetable juice beverage, tea beverage, dairy products,
In Flour product or meat products, the health food with corresponding healthcare function is become.
Health material in the formula (1) is added one kind in other seven kinds of raw materials by flower of Fructus Momordicae, Siraitia grosvenorii and lily
More than one raw materials composition or by flower of Fructus Momordicae, Siraitia grosvenorii and spina date seed add one kind in other seven kinds of raw materials or it is a kind of with
Upper raw material composition adds one or more kinds of raw materials in other seven kinds of raw materials to form by flower of Fructus Momordicae, Siraitia grosvenorii and lichee,
Or it is made of one or more kinds of raw materials in flower of Fructus Momordicae, Siraitia grosvenorii and longan (longan) plus other seven kinds of raw materials；
The use ratio of raw material is 100 parts of flower of Fructus Momordicae, 10-150 parts of Siraitia grosvenorii, Radix Glycyrrhizae 0.1-10 in the formula (1)
Part, 0.1-5 parts of Leaves of Glycyrrhiza Uralensis Fisch, 0.1-100 parts of lily, 0.1-100 parts of wild jujube, 0.1-100 parts of spina date seed, 0.1-100 parts of lichee and
0.1-100 parts of longan (longan)；
Step (2) the mixed raw material amount of water is 10-20 times of raw material weight, and 85-100 DEG C of stew fire boils 30-90min,
Infusion adds a certain amount of edible alcohol adjusting alcoholic strength to 25-75% after terminating cooling, and room temperature extracts 5-20d, leaching after sealing
Extract filtering and removing slag are concentrated in vacuo to raw mixture weight.
It is yellow rice wine, white wine, red wine, beer etc. that the range and ratio that concentrate adds in the step (3), which are alcoholic beverage,；
Its adding proportion is that the adding proportion in 1-10% (v/v), fruit juice and fruit-vegetable juice beverage is adding in 1-5% (v/v), tea beverage
It is adding proportion in 0.5-5% (v/v), Flour product is 1- that ratio is added, which to be the adding proportion in 1-5% (v/v), dairy products,
Adding proportion in 10% (w/w), meat products is 1-10% (w/w).
Above-mentioned formula and step are in the health care formula and preparation method and application that relax bowel with soporific function
Application.
Compared with prior art, the present invention having the following advantages that and advantageous effect：
(1) primary raw material flower of Fructus Momordicae, Siraitia grosvenorii, lily, spina date seed, lichee and the longan (longan) that the present invention uses are
Raw material or civil long-term safety are eaten in the healthy food material catalogue of state food pharmaceuticals administration general bureau of China publication
Raw material, it is safe, can be used for a long time；(2) above-mentioned formulation efficacy is notable, and 1-3 days take effect, and raw material is common original
Expect, is cheap；(3) with the improvement of people ' s living standards, the quickening of live and work rhythm, the people be engaged in manual labor and
Amount of exercise substantially reduces, while the stress of people increases.Dyspepsia caused by for these reasons, be hard and dry, constipation, coke
Consider and insomnia crowd gradually increases.Therefore, the quality of life that the present invention will significantly improve above-mentioned crowd has important economic valency
Value and social effect.Therefore, compared with prior art, the present invention with product with safe, with obvious effects and economic valency
The advantages such as value and social value height.
Specific embodiment
The specific embodiment of the present invention is described further with reference to example, but the implementation of the present invention and protection model
It encloses without being limited thereto.
Embodiment 1 is a kind of with the health-care yellow wine to relax bowel with soporific function
Specific implementation carries out as steps described below：
(1) using flower of Fructus Momordicae, Siraitia grosvenorii, Leaves of Glycyrrhiza Uralensis Fisch, wild jujube and lichee as health material；
(2) use ratio of raw material is 100 parts of flower of Fructus Momordicae, 10 parts of Siraitia grosvenorii, 0.1 part of Leaves of Glycyrrhiza Uralensis Fisch, wild jujube in above-mentioned (1)
100 parts of 0.1 part, 0.1 part of spina date seed and lichee；
(3) above-mentioned (1) Siraitia grosvenorii and lichee craft broken shell, arhat shell are continued to employ, and lychee exocarp abandons, according in step (2)
Ratio mixed raw material adds the tap water of 10 times of raw material weight, and 85 DEG C are boiled 30min, and infusion adds a certain amount of food after terminating cooling
Alcoholic strength is adjusted to 25% with alcohol, and room temperature extracts 5d after sealing, and leaching liquor filtering and removing slag are concentrated in vacuo to raw mixture weight
Amount.
(4) concentrate in (3) is added in the yellow rice wine blent, makes to contain concentrate 1% (v/v) in (3) in yellow rice wine, it
Yellow rice wine is filtered according to common process, sterilizes, detecting afterwards, filling and packaging is to get with relaxing bowel and soporific function
Health-care yellow wine.
(5) zoopery
1) relax bowel zoopery：Kunming mouse 100 (Nanjing Jun Ke bioengineering Co., Ltd), male and female are each
Half, 18~22g of weight.It is divided into blank group, model group and tested group (low dose group, middle dose group and high dose group), every group female
Male each 10, male and female are separately raised.The tested group of daily gavage of mouse is primary, low dose group gavage amount for 0.05ml health-care yellow wines/
20g mouse, middle dose group gavage amount are 0.1ml health-care yellow wines/20g mouse, high dose group gavage amount be 0.2ml health-care yellow wines/
20g mouse.After 14d, blank group, model group and tested group are deprived of food but not water 16h, model group and each dosage group gavage of health-care yellow wine
Compound diphenoxylate (10mg/kg) is given, blank control group is to distilled water.After giving compound diphenoxylate 0.5h, tested each group
Prepared Chinese ink (containing 5% active powdered carbon, 10% gum arabic) of the gavage containing corresponding given the test agent, blank control group, model group are given
Prepared Chinese ink gavage.Since being filled prepared Chinese ink, record every mouse and arrange first grain melena time, the interior row's melena grain numbers of 6h and quality.
1 health-care yellow wine of table to test mice functions of loosening bowel relieving constipation (N=20)
Note："-" represents that study dosage is 0；Without identical letter two groups of significant differences of numerical value of explanation after same row numerical value
Different (p ＜ 0.05).
As shown in Table 1, compared with model group, the health-care yellow wine of any dosage is taken in, defecation time has shortening for the first time,
The total grain number of defecation and defecation gross mass are improved, and wherein defecation time significantly shortens for the first time for middle dose group and high dose group,
Defecation grain number and defecation quality significantly improve.Compared with blank group, in addition to defecation time significant difference for the first time, each study dosage group
The total grain number of its defecation of mouse and gross mass and blank group are without significant difference.Data above illustrates what is produced according to the method for the present invention
Health-care yellow wine has significant functions of loosening bowel relieving constipation.
2) sleeping zoopery：
After above-mentioned blank group and tested group of mouse continue raising 1 week according to original method for breeding, tested group in last dose
After 30min, each group mouse peritoneal injection yellow Jackets 40mg/kg, using righting reflex loss as time for falling asleep, righting reflex disappears
It is sleep time to lose to recovery time.The sleeping time of each group mouse is recorded (with more than mouse righting reflex loss 1min
Person is then denoted as and sleeps).
2 health-care yellow wine of table to test mice soporific function (N=20)
Note："-" represents that study dosage is 0；Without identical letter two groups of significant differences of numerical value of explanation after same row numerical value
Different (p ＜ 0.05).
As shown in Table 2, tested group of mouse sleep time is longer than naive mice sleeping time, wherein high dose group mouse
Sleeping time extension more notable than naive mice sleeping time.Data above illustrates the health-care yellow wine produced according to the method for the present invention
With significant soporific function.
Embodiment 2 is a kind of with the health-care spirit to relax bowel with soporific function
Specific implementation carries out as steps described below：
(1) with flower of Fructus Momordicae, Siraitia grosvenorii, Radix Glycyrrhizae, lily, spina date seed and longan (longan) for health material；
(2) use ratio of raw material is 100 parts of flower of Fructus Momordicae, 150 parts of Siraitia grosvenorii, 10 parts of Radix Glycyrrhizae, lily in above-mentioned (1)
100 parts of 100 parts, 100 parts of spina date seed and longan (longan)；
(3) raw material Radix Glycyrrhizae, spiny jujuba seed powder are broken to 20 mesh in above-mentioned (1), and Siraitia grosvenorii, lichee and longan (longan) are broken by hand
Shell, arhat shell are continued to employ, and longan pericarp abandons, and according to ratio mixed raw material in step (2), adds the tap water of 20 times of raw material weight,
100 DEG C are boiled 90min, and infusion adds a certain amount of edible alcohol adjusting alcoholic strength to 75% after terminating cooling, and room temperature soaks after sealing
20d is carried, leaching liquor filtering and removing slag are concentrated in vacuo to raw mixture weight.
(4) concentrate in (3) is added in the white wine blent, makes to contain concentrate 10% (v/v) in (3) in white wine,
It is detected later according to white wine common process, filling and packaging is to get with the health-care spirit to relax bowel with soporific function.
(5) zoopery
1) relax bowel zoopery：Kunming mouse 100 (Nanjing Jun Ke bioengineering Co., Ltd), male and female are each
Half, 18~22g of weight.It is divided into blank group, model group and tested group (low dose group, middle dose group and high dose group), every group female
Male each 10, male and female are separately raised.The tested group of daily gavage of mouse is primary, low dose group gavage amount for 0.02ml health-care spirits/
20g mouse, middle dose group gavage amount are 0.04ml health-care spirits/20g mouse, high dose group gavage amount is that 0.06ml health cares are white
Wine/20g mouse.After 14d, blank group, model group and tested group are deprived of food but not water 16h, model group and each dosage group of health-care spirit
Gavage gives compound diphenoxylate (10mg/kg), and blank control group is to distilled water.It is tested after giving compound diphenoxylate 0.5h
Prepared Chinese ink (containing 5% active powdered carbon, 10% gum arabic) of each group gavage containing corresponding given the test agent, blank control group, model group
Give prepared Chinese ink gavage.Since being filled prepared Chinese ink, record every mouse and arrange first grain melena time, the interior row's melena grain numbers of 6h and quality.
3 health-care spirit of table to test mice functions of loosening bowel relieving constipation (N=20)
Note："-" represents that study dosage is 0；Without identical letter two groups of significant differences of numerical value of explanation after same row numerical value
Different (p ＜ 0.05).
As shown in Table 3, compared with model group, the health-care spirit of any dosage is taken in, defecation time has shortening for the first time,
The total grain number of defecation and defecation gross mass are improved, and wherein defecation time, defecation grain number and defecation quality are equal for the first time for high dose group
Significantly shorten.Compared with blank group, in addition to defecation time significant difference for the first time, the total grain number of its defecation of each study dosage group mouse and
Gross mass and blank group are without significant difference.Data above illustrates to have according to the health-care spirit that the method for the present invention produces significant
Functions of loosening bowel relieving constipation.
2) sleeping zoopery：
After above-mentioned blank group and tested group of mouse continue raising 1 week according to original method for breeding, tested group in last dose
After 30min, each group mouse peritoneal injection yellow Jackets 40mg/kg, using righting reflex loss as time for falling asleep, righting reflex disappears
It is sleep time to lose to recovery time.The sleeping time of each group mouse is recorded (with more than mouse righting reflex loss 1min
Person is then denoted as and sleeps).
4 health-care spirit of table to test mice soporific function (N=20)
Note："-" represents that study dosage is 0；Without identical letter two groups of significant differences of numerical value of explanation after same row numerical value
Different (p ＜ 0.05).
As shown in Table 4, tested group of mouse sleep time is longer than naive mice sleeping time, wherein middle dose group and height
The extension more notable than naive mice sleeping time of dosage group mouse sleep time.Data above explanation is produced according to the method for the present invention
Health-care spirit have significant soporific function.
Embodiment 3 is a kind of with the health-care dairy products to relax bowel with soporific function
(1) it is with flower of Fructus Momordicae, Siraitia grosvenorii, Radix Glycyrrhizae, Leaves of Glycyrrhiza Uralensis Fisch, lily, wild jujube, spina date seed, lichee and longan (longan)
Health material；
(2) use ratio of raw material is 100 parts of flower of Fructus Momordicae, 50 parts of Siraitia grosvenorii, 2.5 parts of Radix Glycyrrhizae, Leaves of Glycyrrhiza Uralensis Fisch in above-mentioned (1)
0.1 part of 0.1 part, 0.1 part of lily, 100 parts of wild jujube, 50 parts of spina date seed, 0.1 part of lichee and longan (longan)；
(3) raw material Radix Glycyrrhizae, spiny jujuba seed powder are broken to 20 mesh in above-mentioned (1), and Siraitia grosvenorii, lichee and longan (longan) are broken by hand
Shell, arhat shell are continued to employ, and lichee and longan pericarp abandon, and according to ratio mixed raw material in step (2), add 15 times of raw material weight oneself
Water, 90 DEG C are boiled 60min, and infusion adds a certain amount of edible alcohol adjusting alcoholic strength to 55% after terminating cooling, normal after sealing
Temperature extraction 15d, leaching liquor filtering and removing slag are concentrated in vacuo to raw mixture weight.
(4) concentrate in (3) is added in acidified milk after fermentation, made in acidified milk containing concentrate in (3)
10%, it is stirred, cools down according to acidified milk common process later, after-ripening and detection are made to get with relaxing bowel with sleeping
Health care acidified milk.
(5) zoopery
1) relax bowel zoopery：Kunming mouse 100 (Nanjing Jun Ke bioengineering Co., Ltd), male and female are each
Half, 18~22g of weight.It is divided into blank group, model group and tested group (low dose group, middle dose group and high dose group), every group female
Male each 10, male and female are separately raised.The tested group of daily gavage of mouse is primary, and low dose group gavage amount is 0.03ml health breast systems
Product/20g mouse, middle dose group gavage amount are 0.06ml health-care dairy products/20g mouse, high dose group gavage amount is that 0.09ml is protected
Strong dairy products/20g mouse.After 14d, blank group, model group and tested group are deprived of food but not water 16h, model group and health-care dairy products
Each dosage group gavage gives compound diphenoxylate (10mg/kg), and blank control group is to distilled water.Give compound diphenoxylate 0.5h
Afterwards, prepared Chinese ink (containing 5% active powdered carbon, 10% gum arabic) of the tested each group gavage containing corresponding given the test agent, blank control group,
Model group gives prepared Chinese ink gavage.Since being filled prepared Chinese ink, record every mouse and arrange first grain melena time, the interior row's melena grain numbers of 6h and matter
Amount.
5 health-care dairy products of table to test mice functions of loosening bowel relieving constipation (N=20)
Note："-" represents that study dosage is 0；Without identical letter two groups of significant differences of numerical value of explanation after same row numerical value
Different (p ＜ 0.05).
As shown in Table 5, compared with model group, the health-care dairy products of any dosage are taken in, defecation time has contracting for the first time
Short, the total grain number of defecation and defecation gross mass are improved, wherein high dose group defecation time, defecation grain number and defecation quality for the first time
Significantly shorten.Compared with blank group, in addition to defecation time significant difference for the first time, the total grain number of its defecation of each study dosage group mouse
With gross mass and blank group without significant difference.Data above illustrates to have according to the health-care dairy products that the method for the present invention produces aobvious
The functions of loosening bowel relieving constipation of work.
2) sleeping zoopery：
After above-mentioned blank group and tested group of mouse continue raising 1 week according to original method for breeding, tested group in last dose
After 30min, each group mouse peritoneal injection yellow Jackets 40mg/kg, using righting reflex loss as time for falling asleep, righting reflex disappears
It is sleep time to lose to recovery time.The sleeping time of each group mouse is recorded (with more than mouse righting reflex loss 1min
Person is then denoted as and sleeps).
6 health-care dairy products of table to test mice soporific function (N=20)
Note："-" represents that study dosage is 0；Without identical letter two groups of significant differences of numerical value of explanation after same row numerical value
Different (p ＜ 0.05).
As shown in Table 6, tested group of mouse sleep time is longer than naive mice sleeping time, wherein middle dose group and height
The extension more notable than naive mice sleeping time of dosage group mouse sleep time.Data above explanation is produced according to the method for the present invention
Health-care dairy products have significant soporific function.
Embodiment 4 is a kind of with the health care fruit-vegetable juice beverage to relax bowel with soporific function
(1) with flower of Fructus Momordicae, Siraitia grosvenorii, wild jujube, Leaves of Glycyrrhiza Uralensis Fisch, lichee and longan (longan) for health material；
(2) use ratio of raw material is 100 parts of flower of Fructus Momordicae, 30 parts of Siraitia grosvenorii, 5 parts of Leaves of Glycyrrhiza Uralensis Fisch, wild jujube 10 in above-mentioned (1)
50 parts of part, 50 parts of lichee and longan (longan)；
(3) the manual broken shell of Siraitia grosvenorii, lichee and longan (longan), arhat shell are continued to employ in above-mentioned (1), lichee and longan pericarp
It abandons, according to ratio mixed raw material in step (2), adds the tap water of 12 times of raw material weight, 95 DEG C are boiled 60min, and infusion terminates cold
But a certain amount of edible alcohol is added afterwards and adjusts alcoholic strength to 40%, and room temperature extracts 10d after sealing, leaching liquor filtering and removing slag, very
Sky is concentrated into raw mixture weight.
(4) concentrate in (3) is added in the juice after squeezing and extraction, made in juice containing concentrating in (3)
Liquid 2% (v/v), clarified, filtered according to juice common process later, homogeneous, deoxidation, composition adjustment, packaging, sterilization and
Detection is to get with the health care juice to relax bowel with soporific function.
(5) zoopery
1) relax bowel zoopery：Kunming mouse 100 (Nanjing Jun Ke bioengineering Co., Ltd), male and female are each
Half, 18~22g of weight.It is divided into blank group, model group and tested group (low dose group, middle dose group and high dose group), every group female
Male each 10, male and female are separately raised.The tested group of daily gavage of mouse is primary, and low dose group gavage amount is 0.05ml health care fruits and vegetables
Juice/20g mouse, middle dose group gavage amount are 0.1ml health cares juice/20g mouse, high dose group gavage amount is 0.2ml health cares
Juice/20g mouse.After 14d, blank group, model group and tested group are deprived of food but not water 16h, and model group and health care juice are each
Dosage group gavage gives compound diphenoxylate (10mg/kg), and blank control group is to distilled water.Give compound diphenoxylate 0.5h
Afterwards, prepared Chinese ink (containing 5% active powdered carbon, 10% gum arabic) of the tested each group gavage containing corresponding given the test agent, blank control group,
Model group gives prepared Chinese ink gavage.Since being filled prepared Chinese ink, record every mouse and arrange first grain melena time, the interior row's melena grain numbers of 6h and matter
Amount.
7 health care juice of table to test mice functions of loosening bowel relieving constipation (N=20)
Note："-" represents that study dosage is 0；Without identical letter two groups of significant differences of numerical value of explanation after same row numerical value
Different (p ＜ 0.05).
As shown in Table 7, compared with model group, the health care juice of any dosage is taken in, defecation time has contracting for the first time
Short, the total grain number of defecation and defecation gross mass are improved, wherein high dose group defecation time, defecation grain number and defecation quality for the first time
Significantly shorten.Compared with blank group, in addition to defecation time significant difference for the first time, the total grain number of each its defecation of dosage group mouse and total
Quality and blank group are without significant difference.Data above illustrates to have according to the health care juice that the method for the present invention produces significant
Functions of loosening bowel relieving constipation.
2) sleeping zoopery：
After above-mentioned blank group and tested group of mouse continue raising 1 week according to original method for breeding, tested group in last dose
After 30min, each group mouse peritoneal injection yellow Jackets 40mg/kg, using righting reflex loss as time for falling asleep, righting reflex disappears
It is sleep time to lose to recovery time.The sleeping time of each group mouse is recorded (with more than mouse righting reflex loss 1min
Person is then denoted as and sleeps).
8 health-care dairy products of table to test mice soporific function (N=20)
Note："-" represents that study dosage is 0；Without identical letter two groups of significant differences of numerical value of explanation after same row numerical value
Different (p ＜ 0.05).
As shown in Table 8, tested group of mouse sleep time is longer than naive mice sleeping time, wherein middle dose group and height
The extension more notable than naive mice sleeping time of dosage group mouse sleep time.Data above explanation is produced according to the method for the present invention
Health care juice have significant soporific function.
Embodiment 5 is a kind of with the health-care tea beverage to relax bowel with soporific function
(1) with flower of Fructus Momordicae, Siraitia grosvenorii, wild jujube, Leaves of Glycyrrhiza Uralensis Fisch, lichee and longan (longan) for health material；
(2) use ratio of raw material is 100 parts of flower of Fructus Momordicae, 80 parts of Siraitia grosvenorii, 2 parts of Leaves of Glycyrrhiza Uralensis Fisch, spina date seed in above-mentioned (1)
75 parts of 50 parts, 25 parts of lichee and longan (longan)；
(3) the manual broken shell of Siraitia grosvenorii, lichee and longan (longan), arhat shell are continued to employ in above-mentioned (1), lichee and longan pericarp
It abandons, according to ratio mixed raw material in step (2), adds the tap water of 16 times of raw material weight, 95 DEG C are boiled 45min, and infusion terminates cold
But a certain amount of edible alcohol is added afterwards and adjusts alcoholic strength to 60%, and room temperature extracts 15d after sealing, leaching liquor filtering and removing slag, very
Sky is concentrated into raw mixture weight.
(4) concentrate in (3) is added in the tealeaves extract after squeezing and extraction, made in tea beverage containing in (3)
Concentrate 2% (v/v), allocated, filtered according to tea beverage common process later, deoxidation, high pressure instantaneous sterilization, packaging and inspection
It surveys to get with the health-care tea beverage to relax bowel with soporific function.
(5) zoopery
1) relax bowel zoopery：Kunming mouse 100 (Nanjing Jun Ke bioengineering Co., Ltd), male and female are each
Half, 18~22g of weight.It is divided into blank group, model group and tested group (low dose group, middle dose group and high dose group), every group female
Male each 10, male and female are separately raised.The tested group of daily gavage of mouse is primary, and low dose group gavage amount is 0.04ml health teas
Material/20g mouse, middle dose group gavage amount are 0.08ml health-care tea beverages/20g mouse, high dose group gavage amount is that 0.12ml is protected
Strong tea beverage/20g mouse.After 14d, blank group, model group and tested group are deprived of food but not water 16h, model group and health-care tea beverage
Each dosage group gavage gives compound diphenoxylate (10mg/kg), and blank control group is to distilled water.Give compound diphenoxylate 0.5h
Afterwards, prepared Chinese ink (containing 5% active powdered carbon, 10% gum arabic) of the tested each group gavage containing corresponding given the test agent, blank control group,
Model group gives prepared Chinese ink gavage.Since being filled prepared Chinese ink, record every mouse and arrange first grain melena time, the interior row's melena grain numbers of 6h and matter
Amount.
9 health-care tea beverage of table to test mice functions of loosening bowel relieving constipation (N=20)
Note："-" represents that study dosage is 0；Without identical letter two groups of significant differences of numerical value of explanation after same row numerical value
Different (p ＜ 0.05).
As shown in Table 9, compared with model group, the health-care tea beverage of any dosage is taken in, defecation time has contracting for the first time
Short, the total grain number of defecation and defecation gross mass are improved, wherein high dose group defecation time, defecation grain number and defecation quality for the first time
Significantly shorten (defecation time also significantly shortens middle dose group for the first time).Compared with blank group, except defecation time difference is shown for the first time
Write outer, the total grain number of each its defecation of dosage group mouse and gross mass and blank group are without significant difference.Data above explanation is according to this
The health-care tea beverage of inventive method production has significant functions of loosening bowel relieving constipation.
2) sleeping zoopery：
After above-mentioned blank group and tested group of mouse continue raising 1 week according to original method for breeding, tested group in last dose
After 30min, each group mouse peritoneal injection yellow Jackets 40mg/kg, using righting reflex loss as time for falling asleep, righting reflex disappears
It is sleep time to lose to recovery time.The sleeping time of each group mouse is recorded (with more than mouse righting reflex loss 1min
Person is then denoted as and sleeps).
10 health-care tea beverage of table to test mice soporific function (N=20)
Note："-" represents that study dosage is 0；Without identical letter two groups of significant differences of numerical value of explanation after same row numerical value
Different (p ＜ 0.05).
As shown in Table 10, tested group of mouse sleep time is longer than naive mice sleeping time, wherein middle dose group and
The extension more notable than naive mice sleeping time of high dose group mouse sleep time.Data above explanation is given birth to according to the method for the present invention
The health-care tea beverage of production has significant soporific function.
Embodiment 6 is a kind of with the health-care sausage to relax bowel with soporific function
(1) using flower of Fructus Momordicae, Siraitia grosvenorii, Radix Glycyrrhizae, spina date seed as health material；
(2) use ratio of raw material is 100 parts of flower of Fructus Momordicae, 70 parts of Siraitia grosvenorii, 5 parts of Radix Glycyrrhizae and spina date seed in above-mentioned (1)
80 parts；
(3) raw material Radix Glycyrrhizae, spiny jujuba seed powder are broken to 20 mesh, Siraitia grosvenorii craft broken shell in above-mentioned (1), and arhat shell is continued to employ, pressed
According to ratio mixed raw material in step (2), add the tap water of 16 times of raw material weight, 95 DEG C are boiled 70min, and infusion is added after terminating cooling
A certain amount of edible alcohol adjusts alcoholic strength to 60%, and room temperature extracts 12d after sealing, and leaching liquor filtering and removing slag are concentrated in vacuo to
Raw mixture weight.
(4) concentrate in (3) and auxiliary material are added to together blend it is nauseating in, make in sausage containing concentrate in (3)
5% (w/w) is stirred according to sausage common process, bowel lavage, ligation, string extension, drying, baking, packs and examine, i.e., later
It obtains with the health-care sausage to relax bowel with soporific function.
(5) zoopery
1) relax bowel zoopery：Kunming mouse 100 (Nanjing Jun Ke bioengineering Co., Ltd), male and female are each
Half, 18~22g of weight.It is divided into blank group, model group and tested group (low dose group, middle dose group and high dose group), every group female
Male each 10, male and female are separately raised.Health-care sausage is crushed and is mixed and made into mouse grain with feedstuff, is averaged food ration according to mouse
The mouse grain containing health-care sausage of three kinds of concentration is prepared, the health-care sausage amount for making tested group of mouse daily ingestion of is 0.04g health cares
Sausage/20g mouse, 0.08g health-care sausages/20g mouse, 0.12g health-care sausages/20g mouse.After 14d, blank group, model group
16h is deprived of food but not water with tested group, model group and each dosage group gavage of health-care sausage give compound diphenoxylate (10mg/kg),
Blank control group is to distilled water.After giving compound diphenoxylate 0.5h, the prepared Chinese ink of gavage corresponding amount after tested each group ad lib
(containing 5% active powdered carbon, 10% gum arabic), prepared Chinese ink gavage is given after blank control group, model group feed.It is opened from prepared Chinese ink is filled
Begin, record every mouse and arrange first grain melena time, the interior row's melena grain numbers of 6h and quality.
11 health-care sausage of table to test mice functions of loosening bowel relieving constipation (N=20)
Note："-" represents that study dosage is 0；Without identical letter two groups of significant differences of numerical value of explanation after same row numerical value
Different (p ＜ 0.05).
As shown in Table 11, compared with model group, the health-care sausage of any dosage is taken in, defecation time has contracting for the first time
Short, the total grain number of defecation and defecation gross mass are improved, and wherein defecation time significantly contracts for the first time for middle dose group and high dose group
Short, high dose group defecation grain number significantly improves, and middle dose group and high dose group defecation quality significantly improve.Compared with blank group,
In addition to defecation time significant difference for the first time, the total grain number of each its defecation of dosage group mouse and gross mass and blank group are without significance difference
It is different.Data above illustrates there is significant functions of loosening bowel relieving constipation according to the health-care sausage that the method for the present invention produces.
2) sleeping zoopery：
After above-mentioned blank group and tested group of mouse continue raising 1 week according to original method for breeding, tested group in last dose
After 30min, each group mouse peritoneal injection yellow Jackets 40mg/kg, using righting reflex loss as time for falling asleep, righting reflex disappears
It is sleep time to lose to recovery time.The sleeping time of each group mouse is recorded (with more than mouse righting reflex loss 1min
Person is then denoted as and sleeps).
12 health-care sausage of table to test mice soporific function (N=20)
Note："-" represents that study dosage is 0；Without identical letter two groups of significant differences of numerical value of explanation after same row numerical value
Different (p ＜ 0.05).
As shown in Table 12, tested group of mouse sleep time is longer than naive mice sleeping time, wherein middle dose group and
The extension more notable than naive mice sleeping time of high dose group mouse sleep time.Data above explanation is given birth to according to the method for the present invention
The health-care sausage of production has significant soporific function.
Embodiment 7 is a kind of with the health-caring biscuit to relax bowel with soporific function
(1) with flower of Fructus Momordicae, Siraitia grosvenorii, Radix Glycyrrhizae, spina date seed and longan (longan) for health material；
(2) use ratio of raw material is 100 parts of flower of Fructus Momordicae, 45 parts of Siraitia grosvenorii, 3 parts of Radix Glycyrrhizae, spina date seed 45 in above-mentioned (1)
55 parts of part and longan (longan)；
(3) raw material Radix Glycyrrhizae, spiny jujuba seed powder are broken to 20 mesh, Siraitia grosvenorii and the manual broken shell of longan (longan), arhat in above-mentioned (1)
Shell is continued to employ, and longan pericarp abandons, and according to ratio mixed raw material in step (2), adds the tap water of 16 times of raw material weight, 85 DEG C are boiled
75min, infusion add a certain amount of edible alcohol adjusting alcoholic strength to 50% after terminating cooling, and room temperature extracts 10d, leaching after sealing
Extract filtering and removing slag are concentrated in vacuo to raw mixture weight.
(4) concentrate in (3) with water, flour, granulated sugar and other auxiliary materials is mixed, made in biscuit containing concentrate in (3)
7% (w/w), be stirred later according to biscuit common process, dough preparing, molding, baking, cooling conveying, arrange, packaging and
Detection is to get with the health-caring biscuit to relax bowel with soporific function.
(5) zoopery
1) relax bowel zoopery：Kunming mouse 100 (Nanjing Jun Ke bioengineering Co., Ltd), male and female are each
Half, 18~22g of weight.It is divided into blank group, model group and tested group (low dose group, middle dose group and high dose group), every group female
Male each 10, male and female are separately raised.Health-care sausage is crushed and is mixed and made into mouse grain with feedstuff, is averaged food ration according to mouse
The mouse grain containing health-caring biscuit of three kinds of concentration is prepared, the health-care cake dry measure for making tested group of mouse daily ingestion of is 0.03g health-care cakes
Dry/20g mouse, 0.06g health-caring biscuits/20g mouse, 0.09g health-caring biscuits/20g mouse.After 14d, blank group, model group and
Tested group is deprived of food but not water 16h, and model group and each dosage group gavage of health-caring biscuit give compound diphenoxylate (10mg/kg), empty
White control group is to distilled water.After giving compound diphenoxylate 0.5h, a certain amount of prepared Chinese ink of gavage (contains after tested each group ad lib
5% active powdered carbon, 10% gum arabic), give prepared Chinese ink gavage after blank control group, model group feed.Since being filled prepared Chinese ink,
It records every mouse and arranges first grain melena time, the interior row's melena grain numbers of 6h and quality.
13 health-caring biscuit of table to test mice functions of loosening bowel relieving constipation (N=20)
Note："-" represents that study dosage is 0；Without identical letter two groups of significant differences of numerical value of explanation after same row numerical value
Different (p ＜ 0.05).
As shown in Table 13, compared with model group, the health-caring biscuit of any dosage is taken in, defecation time has contracting for the first time
Short, the total grain number of defecation and defecation gross mass are improved, wherein high dose group defecation time, defecation grain number and defecation quality for the first time
Significantly shorten.Compared with blank group, in addition to defecation time significant difference for the first time, the total grain number of its defecation of tested each group and gross mass and
Blank group is without significant difference.Data above illustrates that the health-caring biscuit produced according to the method for the present invention has and significantly relaxes bowel
Effect.
2) sleeping zoopery：
After above-mentioned blank group and tested group of mouse continue raising 1 week according to original method for breeding, tested group in last dose
After 30min, each group mouse peritoneal injection yellow Jackets 40mg/kg, using righting reflex loss as time for falling asleep, righting reflex disappears
It is sleep time to lose to recovery time.The sleeping time of each group mouse is recorded (with more than mouse righting reflex loss 1min
Person is then denoted as and sleeps).
14 health-caring biscuit of table to test mice soporific function (N=20)
Note："-" represents that study dosage is 0；Without identical letter two groups of significant differences of numerical value of explanation after same row numerical value
Different (p ＜ 0.05).
As shown in Table 14, tested group of mouse sleep time is longer than naive mice sleeping time, wherein middle dose group and
The extension more notable than naive mice sleeping time of high dose group mouse sleep time.Data above explanation is given birth to according to the method for the present invention
The health-caring biscuit of production has significant soporific function.
Although the present invention has been described by way of example and in terms of the preferred embodiments, it is not limited to the present invention, any to be familiar with this skill
The people of art without departing from the spirit and scope of the present invention, can do various change and modification, therefore the protection model of the present invention
Enclosing be subject to what claims were defined.
Claims (7)
1. with the health caring product prescription to relax bowel with soporific function, it is characterised in that be made of following raw materials according：
(1) formula composition：
100 parts of flower of Fructus Momordicae,
1-200 parts of Siraitia grosvenorii,
0.1-50 parts of Radix Glycyrrhizae,
0.1-10 parts of Leaves of Glycyrrhiza Uralensis Fisch,
0.1-200 parts of lily,
0.1-200 parts of wild jujube,
0.1-200 parts of spina date seed,
0.1-200 parts of lichee,
0.1-200 parts of longan (longan)；
With flower of Fructus Momordicae plus two or more raw material stated in other eight kinds of raw materials and according to aforementioned proportion compositing formula.
It is 2. according to claim 1 with the preparation method to relax bowel with the health caring product prescription of soporific function, feature
It is to carry out as steps described below：
(2) raw material Radix Glycyrrhizae, spina date seed crush in above-mentioned formula (1), the manual broken shell of Siraitia grosvenorii, lichee and longan (longan), arhat
Shell is continued to employ, and lichee and longan pericarp abandon, and according to ratio mixed raw material in formula (1), adds the tap water of 5-30 times of raw material weight,
60-100 DEG C is boiled 10-180min, and infusion adds a certain amount of edible alcohol adjusting alcoholic strength to 5-95%, sealing after terminating cooling
Room temperature extraction 1-30d, leaching liquor filtering and removing slag are concentrated in vacuo to raw mixture weight afterwards.
(3) concentrate in (2) is added to alcoholic beverage, fruit-vegetable juice beverage, tea beverage, dairy products, face system according to a certain percentage
In product or meat products, the health food with corresponding healthcare function is become.
3. it is according to claim 2 with the preparation method to relax bowel with the health caring product prescription of soporific function, feature
It is that the health material in the formula (1) is added one kind or one in other seven kinds of raw materials by flower of Fructus Momordicae, Siraitia grosvenorii and lily
Kind or more raw material composition or add the one or more in other seven kinds of raw materials former by flower of Fructus Momordicae, Siraitia grosvenorii and spina date seed
Material composition or added by flower of Fructus Momordicae, Siraitia grosvenorii and lichee one or more kinds of raw materials in other seven kinds of raw materials form or by
One or more kinds of raw materials composition in flower of Fructus Momordicae, Siraitia grosvenorii and longan (longan) plus other seven kinds of raw materials.
It is 4. according to claim 2 with the preparation method to relax bowel with the health caring product prescription of soporific function, feature
The use ratio for being raw material in the formula (1) is 100 parts of flower of Fructus Momordicae, 10-150 parts of Siraitia grosvenorii, 0.1-10 parts of Radix Glycyrrhizae, sweet
0.1-5 parts of blade of grass, 0.1-100 parts of lily, 0.1-100 parts of wild jujube, 0.1-100 parts of spina date seed, 0.1-100 parts of lichee and longan
0.1-100 parts of (longan).
It is 5. according to claim 2 with the preparation method to relax bowel with the health caring product prescription of soporific function, feature
It is 10-20 times that the step (2) mixed raw material amount of water is raw material weight, 85-100 DEG C of stew fire boils 30-90min, infusion
A certain amount of edible alcohol adjusting alcoholic strength is added to 25-75% after terminating cooling, and room temperature extracts 5-20d, leaching liquor after sealing
Filtering and removing slag are concentrated in vacuo to raw mixture weight.
It is 6. according to claim 2 with the preparation method to relax bowel with the health caring product prescription of soporific function, feature
It is yellow rice wine, white wine, red wine, beer etc. to be in the step (3) that the range of concentrate addition and ratio are alcoholic beverage；It adds
It is addition ratio in 1-5% (v/v), tea beverage that ratio is added, which to be the adding proportion in 1-10% (v/v), fruit juice and fruit-vegetable juice beverage,
It is adding proportion in 0.5-5% (v/v), Flour product is 1-10% (w/ that example, which is adding proportion in 1-5% (v/v), dairy products,
W), the adding proportion in meat products is 1-10% (w/w).
7. any contents of claim 1-5 be with relax bowel with the health care formula of soporific function and preparation method and
Application in.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108967619A (en) * | 2018-09-14 | 2018-12-11 | 铜川药王医都科技有限公司 | A kind of autumn health care tea and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1757317A (en) * | 2005-09-17 | 2006-04-12 | 张志祥 | Momordica grosvenori tablets, and its prepn. method |
| CN101810284A (en) * | 2009-12-28 | 2010-08-25 | 王福起 | Hawthorn food with roles of reducing blood fat, benefiting heart and aiding sleep and preparation method thereof |
| CN102396611A (en) * | 2010-09-08 | 2012-04-04 | 高泉育 | Health protection tea for nourishing and protecting liver |
| CN104587167A (en) * | 2015-02-11 | 2015-05-06 | 广州白云山潘高寿药业股份有限公司 | Traditional Chinese medicine extract for nourishing heart and tranquilizing mind as well as preparation method and application thereof and heart-nourishing mind-tranquilizing ointment |
| CN105535412A (en) * | 2013-12-20 | 2016-05-04 | 郑州思辩科技有限公司 | Kidney tonifying and brain strengthening Chinese herbal medicine |
| CN106689508A (en) * | 2015-11-17 | 2017-05-24 | 薛洋 | Formula of health-care tea |
| CN106880755A (en) * | 2017-02-24 | 2017-06-23 | 山东百味堂中药饮片有限公司 | A kind of Qingrun tea and preparation method thereof |
-
2018
- 2018-01-16 CN CN201810038626.XA patent/CN108185433B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1757317A (en) * | 2005-09-17 | 2006-04-12 | 张志祥 | Momordica grosvenori tablets, and its prepn. method |
| CN101810284A (en) * | 2009-12-28 | 2010-08-25 | 王福起 | Hawthorn food with roles of reducing blood fat, benefiting heart and aiding sleep and preparation method thereof |
| CN102396611A (en) * | 2010-09-08 | 2012-04-04 | 高泉育 | Health protection tea for nourishing and protecting liver |
| CN105535412A (en) * | 2013-12-20 | 2016-05-04 | 郑州思辩科技有限公司 | Kidney tonifying and brain strengthening Chinese herbal medicine |
| CN104587167A (en) * | 2015-02-11 | 2015-05-06 | 广州白云山潘高寿药业股份有限公司 | Traditional Chinese medicine extract for nourishing heart and tranquilizing mind as well as preparation method and application thereof and heart-nourishing mind-tranquilizing ointment |
| CN106689508A (en) * | 2015-11-17 | 2017-05-24 | 薛洋 | Formula of health-care tea |
| CN106880755A (en) * | 2017-02-24 | 2017-06-23 | 山东百味堂中药饮片有限公司 | A kind of Qingrun tea and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108967619A (en) * | 2018-09-14 | 2018-12-11 | 铜川药王医都科技有限公司 | A kind of autumn health care tea and preparation method thereof |
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Effective date of registration: 20231117 Address after: 457400 in Nanle County, Puyang City, Henan Province Patentee after: Henan Pratt & Whitney Tiancheng Biotechnology Co.,Ltd. Address before: Zhenjiang City, Jiangsu Province, 212013 Jingkou District Road No. 301 Patentee before: JIANGSU University |