CN108159425A - 用于治疗红斑痤疮的组合物 - Google Patents

用于治疗红斑痤疮的组合物 Download PDF

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Publication number
CN108159425A
CN108159425A CN201810145665.XA CN201810145665A CN108159425A CN 108159425 A CN108159425 A CN 108159425A CN 201810145665 A CN201810145665 A CN 201810145665A CN 108159425 A CN108159425 A CN 108159425A
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CN
China
Prior art keywords
composition
alcohol
oil
group
bpo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810145665.XA
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English (en)
Chinese (zh)
Inventor
哈南·塞尔特库克
奥弗·托莱达诺
哈伊姆·巴尔-西曼托夫
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Sol Gel Technologies Ltd
Original Assignee
Sol Gel Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sol Gel Technologies Ltd filed Critical Sol Gel Technologies Ltd
Priority to CN201810145665.XA priority Critical patent/CN108159425A/zh
Publication of CN108159425A publication Critical patent/CN108159425A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/327Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201810145665.XA 2012-11-27 2012-11-27 用于治疗红斑痤疮的组合物 Pending CN108159425A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810145665.XA CN108159425A (zh) 2012-11-27 2012-11-27 用于治疗红斑痤疮的组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810145665.XA CN108159425A (zh) 2012-11-27 2012-11-27 用于治疗红斑痤疮的组合物
PCT/IL2012/050479 WO2014083557A1 (en) 2012-11-27 2012-11-27 Compositions for the treatment of rosacea
CN201280077293.2A CN104853746B (zh) 2012-11-27 2012-11-27 用于治疗红斑痤疮的组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280077293.2A Division CN104853746B (zh) 2012-11-27 2012-11-27 用于治疗红斑痤疮的组合物

Publications (1)

Publication Number Publication Date
CN108159425A true CN108159425A (zh) 2018-06-15

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201810145665.XA Pending CN108159425A (zh) 2012-11-27 2012-11-27 用于治疗红斑痤疮的组合物
CN201280077293.2A Active CN104853746B (zh) 2012-11-27 2012-11-27 用于治疗红斑痤疮的组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201280077293.2A Active CN104853746B (zh) 2012-11-27 2012-11-27 用于治疗红斑痤疮的组合物

Country Status (7)

Country Link
EP (1) EP2925296B1 (https=)
JP (1) JP6423355B2 (https=)
CN (2) CN108159425A (https=)
CA (2) CA3051403C (https=)
ES (1) ES2861431T3 (https=)
MX (1) MX376183B (https=)
WO (1) WO2014083557A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017068673A1 (ja) * 2015-10-21 2017-04-27 マルホ株式会社 皮膚用の医薬組成物
EP3426706A1 (en) 2016-03-08 2019-01-16 Living Proof, Inc. Long lasting cosmetic compositions
CA3069359C (en) * 2017-07-12 2023-01-10 Sol-Gel Technologies Ltd. Compositions comprising encapsulated tretinoin
EP3681920B1 (en) 2017-09-13 2025-06-25 Living Proof, Inc. Long lasting cosmetic compositions
CA3074845A1 (en) 2017-09-13 2019-03-21 Living Proof, Inc. Color protectant compositions
AU2018370210B2 (en) 2017-11-20 2024-09-26 Living Proof, Inc. Properties for achieving long-lasting cosmetic performance
EP3784711A1 (en) 2018-04-27 2021-03-03 Living Proof, Inc. Long lasting cosmetic compositions
EP3586849A1 (en) * 2018-06-29 2020-01-01 Aprofol AG Folate preparations
JP6811213B2 (ja) * 2018-07-03 2021-01-13 ソル − ゲル テクノロジーズ リミテッド 酒さの治療のための組成物
WO2020170029A2 (en) * 2019-02-19 2020-08-27 Sol-Gel Technologies Ltd. Method for first-line treatment of rosacea

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008093346A2 (en) * 2007-02-01 2008-08-07 Sol-Gel Technologies Ltd. Compositions for topical application comprising a peroxide and retinoid
CN101631594A (zh) * 2006-12-21 2010-01-20 盖尔德马研究及发展公司 包含至少一种维甲酸类和过氧化苯甲酰的乳液
US20100143285A1 (en) * 2006-11-28 2010-06-10 Galderma Research & Development, Biot, France. Dermatological/pharmaceutical compositions comprising benzoyl peroxide, at least one naphthoic acid compound and at least one polyurethane polymer
CN101754677A (zh) * 2007-02-01 2010-06-23 索尔-格尔科技有限公司 制备包含金属氧化物涂层的颗粒的方法和具有金属氧化物涂层的颗粒
CN101969923A (zh) * 2007-11-30 2011-02-09 盖尔德马研究及发展公司 含有至少一种萘甲酸衍生物、过氧化苯甲酰和至少一种成膜剂的组合物、它们的制备方法及其用途
CN102056481A (zh) * 2008-06-05 2011-05-11 陶氏制药科学公司 包含低浓度的在水和水混溶性有机溶剂中的悬浮液形式的过氧苯甲酰的局部药物制剂
US20120064135A1 (en) * 2010-09-15 2012-03-15 Norac Pharma Benzoyl Peroxide Composition, Methods for Making Same, and Pharmaceutical or Cosmetic Formulations Comprising Same, and Uses Thereof
CN102573765A (zh) * 2009-01-05 2012-07-11 溶胶凝胶技术公司 含有涂覆的活性剂的局部组合物
CN102596186A (zh) * 2009-12-31 2012-07-18 索尔-格尔科技有限公司 芯稳定的微胶囊、它们的制备方法以及它们的用途

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* Cited by examiner, † Cited by third party
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ES2366886T1 (es) * 2000-04-21 2011-10-26 Sol-Gel Technologies Ltd. Composición que presenta estabilidad de formulación potenciada y administración de ingredientes activos tópicos potenciado.
GB0301577D0 (en) * 2003-01-23 2003-02-26 Edko Pazarlama Tanitim Ltd Sti Topical pharmaceutical and/or cosmetic dispense systems
FR2886850B1 (fr) 2005-06-10 2007-10-05 Galderma Sa Composition a base d'une avermectine et de peroxyde de benzoyle notamment pour le traitement de la rosacee
WO2008057411A1 (en) * 2006-11-02 2008-05-15 Stiefel Laboratories, Inc. Kits containing benzoyl peroxide pads and another acne-treating composition, and formulations and methods of use therefor
JP2011529392A (ja) * 2008-07-31 2011-12-08 ゾル−ゲル テクノロジー リミテッド 活性成分および金属酸化物シェルを含むマイクロカプセル、その製造方法およびその使用
JP5784619B2 (ja) * 2009-10-21 2015-09-24 ドウ ファーマシューティカル サイエンシーズ、インク. 過酸化ベンゾイルを含む粉末を湿潤させるための方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100143285A1 (en) * 2006-11-28 2010-06-10 Galderma Research & Development, Biot, France. Dermatological/pharmaceutical compositions comprising benzoyl peroxide, at least one naphthoic acid compound and at least one polyurethane polymer
CN101631594A (zh) * 2006-12-21 2010-01-20 盖尔德马研究及发展公司 包含至少一种维甲酸类和过氧化苯甲酰的乳液
WO2008093346A2 (en) * 2007-02-01 2008-08-07 Sol-Gel Technologies Ltd. Compositions for topical application comprising a peroxide and retinoid
CN101754677A (zh) * 2007-02-01 2010-06-23 索尔-格尔科技有限公司 制备包含金属氧化物涂层的颗粒的方法和具有金属氧化物涂层的颗粒
CN101969923A (zh) * 2007-11-30 2011-02-09 盖尔德马研究及发展公司 含有至少一种萘甲酸衍生物、过氧化苯甲酰和至少一种成膜剂的组合物、它们的制备方法及其用途
CN102056481A (zh) * 2008-06-05 2011-05-11 陶氏制药科学公司 包含低浓度的在水和水混溶性有机溶剂中的悬浮液形式的过氧苯甲酰的局部药物制剂
CN102573765A (zh) * 2009-01-05 2012-07-11 溶胶凝胶技术公司 含有涂覆的活性剂的局部组合物
CN102596186A (zh) * 2009-12-31 2012-07-18 索尔-格尔科技有限公司 芯稳定的微胶囊、它们的制备方法以及它们的用途
US20120064135A1 (en) * 2010-09-15 2012-03-15 Norac Pharma Benzoyl Peroxide Composition, Methods for Making Same, and Pharmaceutical or Cosmetic Formulations Comprising Same, and Uses Thereof

Non-Patent Citations (4)

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Title
MONTES, L F等: "Topical treatment of acne rosacea with benzoyl peroxide acetone gel", 《CUTIS》 *
于小兵: "5%过氧苯甲酰治疗蠕形螨感染的酒渣鼻34例临床疗效观察", 《临床皮肤科杂志》 *
侯秀芳: "红斑痤疮的局部治疗进展", 《中国疗养医学》 *
刘颖: "李铁男教授治疗红斑痤疮的临床经验总结", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 *

Also Published As

Publication number Publication date
JP6423355B2 (ja) 2018-11-14
CA3051403A1 (en) 2014-06-05
WO2014083557A1 (en) 2014-06-05
ES2861431T3 (es) 2021-10-06
CN104853746A (zh) 2015-08-19
JP2016501205A (ja) 2016-01-18
CA2889199C (en) 2020-05-19
MX376183B (es) 2025-03-07
MX2015005515A (es) 2015-07-17
EP2925296A1 (en) 2015-10-07
EP2925296B1 (en) 2021-01-06
CN104853746B (zh) 2018-02-23
CA2889199A1 (en) 2014-06-05
CA3051403C (en) 2021-07-20

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Application publication date: 20180615

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