CA3051403C - Compositions for the treatment of rosacea - Google Patents

Compositions for the treatment of rosacea Download PDF

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Publication number
CA3051403C
CA3051403C CA3051403A CA3051403A CA3051403C CA 3051403 C CA3051403 C CA 3051403C CA 3051403 A CA3051403 A CA 3051403A CA 3051403 A CA3051403 A CA 3051403A CA 3051403 C CA3051403 C CA 3051403C
Authority
CA
Canada
Prior art keywords
composition
alcohol
agent
benzoyl peroxide
oil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3051403A
Other languages
English (en)
French (fr)
Other versions
CA3051403A1 (en
Inventor
Haim Bar-Simantov
Hanan Sertchook
Ofer Toledano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sol Gel Technologies Ltd
Original Assignee
Sol Gel Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sol Gel Technologies Ltd filed Critical Sol Gel Technologies Ltd
Publication of CA3051403A1 publication Critical patent/CA3051403A1/en
Application granted granted Critical
Publication of CA3051403C publication Critical patent/CA3051403C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/327Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3051403A 2012-11-27 2012-11-27 Compositions for the treatment of rosacea Active CA3051403C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA2889199A CA2889199C (en) 2012-11-27 2012-11-27 Compositions for the treatment of rosacea
PCT/IL2012/050479 WO2014083557A1 (en) 2012-11-27 2012-11-27 Compositions for the treatment of rosacea
WOPCT/IL2012/050479 2012-11-27

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2889199A Division CA2889199C (en) 2012-11-27 2012-11-27 Compositions for the treatment of rosacea

Publications (2)

Publication Number Publication Date
CA3051403A1 CA3051403A1 (en) 2014-06-05
CA3051403C true CA3051403C (en) 2021-07-20

Family

ID=47428789

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3051403A Active CA3051403C (en) 2012-11-27 2012-11-27 Compositions for the treatment of rosacea
CA2889199A Active CA2889199C (en) 2012-11-27 2012-11-27 Compositions for the treatment of rosacea

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2889199A Active CA2889199C (en) 2012-11-27 2012-11-27 Compositions for the treatment of rosacea

Country Status (7)

Country Link
EP (1) EP2925296B1 (https=)
JP (1) JP6423355B2 (https=)
CN (2) CN108159425A (https=)
CA (2) CA3051403C (https=)
ES (1) ES2861431T3 (https=)
MX (1) MX376183B (https=)
WO (1) WO2014083557A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017068673A1 (ja) * 2015-10-21 2017-04-27 マルホ株式会社 皮膚用の医薬組成物
EP3426706A1 (en) 2016-03-08 2019-01-16 Living Proof, Inc. Long lasting cosmetic compositions
CA3069359C (en) * 2017-07-12 2023-01-10 Sol-Gel Technologies Ltd. Compositions comprising encapsulated tretinoin
EP3681920B1 (en) 2017-09-13 2025-06-25 Living Proof, Inc. Long lasting cosmetic compositions
CA3074845A1 (en) 2017-09-13 2019-03-21 Living Proof, Inc. Color protectant compositions
AU2018370210B2 (en) 2017-11-20 2024-09-26 Living Proof, Inc. Properties for achieving long-lasting cosmetic performance
EP3784711A1 (en) 2018-04-27 2021-03-03 Living Proof, Inc. Long lasting cosmetic compositions
EP3586849A1 (en) * 2018-06-29 2020-01-01 Aprofol AG Folate preparations
JP6811213B2 (ja) * 2018-07-03 2021-01-13 ソル − ゲル テクノロジーズ リミテッド 酒さの治療のための組成物
WO2020170029A2 (en) * 2019-02-19 2020-08-27 Sol-Gel Technologies Ltd. Method for first-line treatment of rosacea

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2366886T1 (es) * 2000-04-21 2011-10-26 Sol-Gel Technologies Ltd. Composición que presenta estabilidad de formulación potenciada y administración de ingredientes activos tópicos potenciado.
GB0301577D0 (en) * 2003-01-23 2003-02-26 Edko Pazarlama Tanitim Ltd Sti Topical pharmaceutical and/or cosmetic dispense systems
FR2886850B1 (fr) 2005-06-10 2007-10-05 Galderma Sa Composition a base d'une avermectine et de peroxyde de benzoyle notamment pour le traitement de la rosacee
WO2008057411A1 (en) * 2006-11-02 2008-05-15 Stiefel Laboratories, Inc. Kits containing benzoyl peroxide pads and another acne-treating composition, and formulations and methods of use therefor
FR2909000B1 (fr) * 2006-11-28 2009-02-06 Galderma Res & Dev S N C Snc Compositions comprenant du peroxyde de benzoyle, au moins un derive de l'acide naphtoique et au moins un compose de type polymeres de polyurethane ou des derives de celui-ci, et leurs utilisations.
FR2910320B1 (fr) * 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
US20100047357A1 (en) * 2007-02-01 2010-02-25 Sol-Gel Technologies Ltd. Compositions for topical application comprising a peroxide and retinoid
AU2008211554B2 (en) * 2007-02-01 2013-12-19 Sol-Gel Technologies Ltd. Method for preparing particles comprising metal oxide coating and particles with metal oxide coating
CN101969923A (zh) * 2007-11-30 2011-02-09 盖尔德马研究及发展公司 含有至少一种萘甲酸衍生物、过氧化苯甲酰和至少一种成膜剂的组合物、它们的制备方法及其用途
CN102056481A (zh) * 2008-06-05 2011-05-11 陶氏制药科学公司 包含低浓度的在水和水混溶性有机溶剂中的悬浮液形式的过氧苯甲酰的局部药物制剂
JP2011529392A (ja) * 2008-07-31 2011-12-08 ゾル−ゲル テクノロジー リミテッド 活性成分および金属酸化物シェルを含むマイクロカプセル、その製造方法およびその使用
AU2010203166A1 (en) * 2009-01-05 2010-07-08 Sol-Gel Technologies Ltd. Topical compositions containing coated active agents
JP5784619B2 (ja) * 2009-10-21 2015-09-24 ドウ ファーマシューティカル サイエンシーズ、インク. 過酸化ベンゾイルを含む粉末を湿潤させるための方法
BR112012012023A2 (pt) * 2009-12-31 2016-05-17 Sol Gel Technologies Ltd processo para preparar microcápsulas, microcápsulas, composição, método para tratar uma condição superficial em um indivíduo, e, uso das microcápsulas
US20120064135A1 (en) * 2010-09-15 2012-03-15 Norac Pharma Benzoyl Peroxide Composition, Methods for Making Same, and Pharmaceutical or Cosmetic Formulations Comprising Same, and Uses Thereof

Also Published As

Publication number Publication date
JP6423355B2 (ja) 2018-11-14
CA3051403A1 (en) 2014-06-05
WO2014083557A1 (en) 2014-06-05
ES2861431T3 (es) 2021-10-06
CN104853746A (zh) 2015-08-19
JP2016501205A (ja) 2016-01-18
CA2889199C (en) 2020-05-19
MX376183B (es) 2025-03-07
CN108159425A (zh) 2018-06-15
MX2015005515A (es) 2015-07-17
EP2925296A1 (en) 2015-10-07
EP2925296B1 (en) 2021-01-06
CN104853746B (zh) 2018-02-23
CA2889199A1 (en) 2014-06-05

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US20200405665A1 (en) Methods for the treatment of rosacea
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JP2015518031A (ja) レチノイド含有マイクロカプセル、その調製方法、及び当該レチノイド含有マイクロカプセルを含む医薬組成物
US20210169841A1 (en) Method for treatment of rosacea in patients aged 65 years and older
JP6788066B2 (ja) 過酸化ベンゾイルおよびアダパレンを含む局所投与用組成物
JP6811213B2 (ja) 酒さの治療のための組成物

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