CN108159222A - 一种治疗病毒性肝炎、肝纤维化的中药组合物 - Google Patents
一种治疗病毒性肝炎、肝纤维化的中药组合物 Download PDFInfo
- Publication number
- CN108159222A CN108159222A CN201711287592.XA CN201711287592A CN108159222A CN 108159222 A CN108159222 A CN 108159222A CN 201711287592 A CN201711287592 A CN 201711287592A CN 108159222 A CN108159222 A CN 108159222A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- radix
- cordyceps sinensis
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Cell Biology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
本发明涉及中药技术领域,具体涉及一种治疗病毒性肝炎、肝纤维化的中药组合物,所述中药组合物由以下重量份的原料制成:茵陈16‑24份、栀子10‑15份、柴胡10‑15份、半夏8‑12份、白术10‑15份、木香10‑15份、丹参12‑18份、藏红花8‑12份、荆三棱10‑15份、龙胆草8‑12份、茯苓12‑18份、泽泻15‑25份、大腹皮13‑17份、鳖甲18‑22份、龟甲18‑22份、山甲8‑12份、乌蛇18‑22份、甘草6‑15份、冬虫夏草8‑12份,本发明中药组合物可恢复肝功,全面清除肝和血中的病毒,促进肝组织修复、肝细胞再生,抑制纤维化组织形成,该中药组合物为排毒、补血兼施的双向性治疗方案,对治疗病毒性肝炎、肝纤维化有显著疗效。
Description
技术领域
本发明涉及中药技术领域,具体涉及一种治疗病毒性肝炎、肝纤维化的中药组合物。
背景技术
肝脏作为人体内最大、功能最多的实质性腺体器官之一,被喻为“人体最大的化工厂”,体内消化、代谢、排泄、解毒和免疫等过程均有肝脏的参与,随着经济的发展、环境污染及食品药品安全事件的高发,导致肝脏功能损害的疾病发病率呈逐年上升趋势。研究表明,肝脏的病变呈现出多样化和难治愈化。目前,肝病的治疗方法主要有病因治疗、饮食治疗和药物治疗,到目前为止还没有效果十分令人满意的药物。寻求一种安全有效且副作用较小的药物治疗防治肝脏功能损害的药物成为临床亟待解决的问题,也成为目前研究的热点之一。
病毒性肝炎是由几种不同的嗜肝病毒(肝炎病毒)引起的以肝脏炎症好久和坏死病变为主的一组感染性疾病,是法定乙类传染病,具有传染性较强、传播途径复杂、流行面广泛、发病率高等特点;部分乙型、丙型和丁型肝炎患者可演变成慢性,并可发展为肝硬化和原发性肝细胞癌,对人民健康危害甚大。目前已确定的有甲型、乙型、丙型、丁型及戊型病毒性肝炎五种类型,其中甲型和戊型病毒性肝炎主要表现为急性肝炎乙型丙型丁型病毒性肝炎可以呈急性肝炎或慢性肝炎的表现,并有发展为肝硬化和肝细胞癌的可能。
肝纤维化是许多慢性致病因素作用于肝脏引起ECM(extra cellular matrix,细胞外基质)过度沉积的共同病理过程,致病因子引起肝脏氧化应激反应和细胞因子的产生是肝纤维化发生的始动环节。核苷类抗病毒药拉夫米(lamivudine)长期应用可改善肝脏的炎症,并可减轻或阻止肝纤维化的进展;维甲酸可抑制HSC(肝星状细胞)前胶原蛋白I、II、IV、纤维粘连蛋白、粘蛋白的合成及促进单核细胞分泌胶原酶,抑制HSC的活化,并使活化的HSC向静止态逆转,从而使ECM(细胞外基质)合成减少,然而,长期使用对肝脏可能有毒性作用。多种药物对肝纤维化的治疗都有一定效,如IFN-γ,虽然观察到有较好的抗纤维化的作用,但对机体的副作用限制了其应用,同时高昂的费用也使一般收入者望而却步。
发明内容
针对现有技术的不足,本发明提供了一种治疗病毒性肝炎、肝纤维化的中药组合物,所述中药组合物可恢复肝功,全面清除肝和血中的病毒,促进肝组织修复、肝细胞再生,抑制纤维化组织形成。
为实现以上目的,本发明通过以下技术方案予以实现:
一种治疗病毒性肝炎、肝纤维化的中药组合物,由以下重量份的原料制成:茵陈16-24份、栀子10-15份、柴胡10-15份、半夏8-12份、白术10-15份、木香10-15份、丹参12-18份、藏红花8-12份、荆三棱10-15份、龙胆草8-12份、茯苓12-18份、泽泻15-25份、大腹皮13-17份、鳖甲18-22份、龟甲18-22份、山甲8-12份、乌蛇18-22份、甘草6-15份、冬虫夏草8-12份。
优选地,所述中药组合物由以下重量份的原料制成:茵陈18-22份、栀子11-13份、柴胡11-14份、半夏9-11份、白术11-13份、木香11-14份、丹参14-16份、藏红花9-11份、荆三棱11-14份、龙胆草9-11份、茯苓14-16份、泽泻18-22份、大腹皮14-16份、鳖甲19-21份、龟甲19-21份、山甲9-11份、乌蛇19-21份、甘草8-12份、冬虫夏草9-11份。
优选地,所述中药组合物由以下重量份的原料制成:茵陈20份、栀子12份、柴胡12份、半夏10份、白术12份、木香12份、丹参15份、藏红花10份、荆三棱12份、龙胆草10份、茯苓15份、泽泻20份、大腹皮15份、鳖甲20份、龟甲20份、山甲10份、乌蛇20份、甘草10份、冬虫夏草10份。
本发明治疗病毒性肝炎、肝纤维化的中药组合物可以制备成各种中药制剂,所述制剂为汤剂、片剂、丸剂、胶囊剂或散剂等,优选为汤剂。
本发明中药汤剂的制备方法,包括以下步骤:
(1)按配方比称取各中药原料,将冬虫夏草研磨成粉,得冬虫夏草药粉,备用;
(2)将除冬虫夏草外的各中药原料加10-12倍量的水浸泡20-30min,之后药材与水一起倒入煎药锅中,武火煮沸后文火煎煮30-40min,过滤,得煎煮液一;之后再向煎药锅中加入7-9倍量的水,武火煮沸后文火煎煮20-25min,过滤,得煎煮液二;合并煎煮液一和煎煮液二,将冬虫夏草药粉加入到合并的煎煮液中,搅拌均匀,即得汤剂。
本发明中,各中药材的药效如下:
茵陈:清热利湿;退黄。主治:黄疸、小便不利、湿疮瘙痒、传染性黄疸型肝炎等。药理学研究有利胆,保护肝功能,解热,抗炎,降血脂,降压,扩冠等作用。
栀子:清热,泻火,凉血。治热病虚烦不眠,黄疸,淋病,消渴,目赤,咽痛,吐血,衄血,血痢,尿血,热毒疮疡,扭伤肿痛。
柴胡:和解表里,疏肝解郁,升阳举陷,退热截疟。用于感冒发热,寒热往来,胸胁胀痛,月经不调,子宫脱垂,脱肛。
半夏:燥湿化痰,降逆止呕,消痞散结。用于痰多咳喘,痰饮眩悸,风痰眩晕,痰厥头痛,呕吐反胃,胸脘痞闷,梅核气;生用外治痈肿痰核。
白术:健脾益气,燥湿利水,止汗,安胎。用于脾虚食少,腹胀泄泻,痰饮眩悸,水肿,自汗,胎动不安。土白术健脾,和胃,安胎。
木香:行气,止痛,健脾,消食。行气止痛;调中导滞。用于胸脘胀痛、泻痢后重、食积不消、不思饮食;中气不省;突发耳聋;蛇虫咬伤;牙痛。
丹参:活血祛瘀,通经止痛,清心除烦,凉血消痈。用于胸痹心痛,脘腹胁痛,瘕瘕积聚,热痹疼痛,心烦不眠,月经不调,痛经经闭,疮疡肿痛。
藏红花:具有养血、活血、补血、行血、理血等功能。主治:血滞经闭、痛经,产后瘀阻,症瘕积聚,铁打伤痛,热入营血,温毒发斑,忧郁痞闷,惊悸发狂。孕妇慎服。
荆三棱:祛瘀通经,破血消症,行气消积。用于血滞经闭,痛经,产后瘀阻腹痛,跌打瘀肿,腹中包块,食积腹痛。
龙胆草:清热燥湿;泻肝定惊。用于湿热黄疸;小便淋痛;阴肿阴痒;湿热带下;肝胆实火之头胀头痛;目赤肿痛;耳聋耳肿;胁痛口苦;热病惊风抽搐。
茯苓:利水渗湿,健脾,宁心。用于水肿尿少,痰饮眩悸,脾虚食少,便溏泄泻,心神不安,惊悸失眠。
泽泻:利水,渗湿,泄热。治小便不利,水肿胀满,呕吐,泻痢,痰饮,脚气,淋病,尿血。
大腹皮:行气宽中,行水消肿。用于湿阻气滞,脘腹胀闷,大便不爽,水肿胀满,脚气浮肿,小便不利。
鳖甲:滋阴潜阳,退热除蒸,软坚散结。用于阴虚发热,骨蒸劳热,阴虚阳亢,头晕目眩,虚风内动,经闭,久疟,疟母。
龟甲:滋阴潜阳,益肾强骨,养血补心,固经止崩。用于阴虚潮热,骨蒸盗汗,头晕目眩,虚风内动,筋骨痿软,心虚健忘,崩漏经多。
山甲:消肿化脓,散淤通络,通经,下乳,活血镇痛。主治:痈疽疮肿,风寒湿痹,经闭,乳汁不通,止血,症痂积聚。
乌蛇:有祛风,活络,定惊的功效。用于风湿顽痹,麻木拘挛,中风口眼喁斜,半身不遂,抽搐痉挛,破伤风,麻风疥癣,瘰疬恶疮。
甘草:清热解毒,润肺止咳,调和诸药;炙甘草能补脾益气。主治咽喉肿痛,咳嗽,脾胃虚弱,胃、十二指肠溃疡,肝炎,癔病,痈疖肿毒,药物及食物中毒。
冬虫夏草:可以增强机体的免疫力,滋补肺肾,对肺癌、肝癌等有明显的抑制作用。在临床上对肺虚久咳,气喘,肺结核咯血,盗汗,肾虚腰膝酸痛,阳痿遗精,神经衰弱及化疗、放疗后的红细胞下降都有疗效
本发明的有益效果是:
(1)本发明中药组合物可恢复肝功,全面清除肝和血中的病毒,促进肝组织修复,肝细胞再生,抑制纤维化组织形成。该中药组合物为排毒、补血兼施的双向性治疗方案,对治疗病毒性肝炎、肝纤维化有显著疗效。
(2)本发明是经过长期的科学验证而成,由纯天然植物中药组成,配伍合理,所制得的中药制剂服用方便,具有疗效快、无副作用的优点,适合推广使用。
具体实施方式
下面结合具体实施例进一步说明本发明的技术解决方案,实施例不能理解为是对技术解决方案的限制。
实施例1:本发明汤剂
原料药:茵陈20份、栀子12份、柴胡12份、半夏10份、白术12份、木香12份、丹参15份、藏红花10份、荆三棱12份、龙胆草10份、茯苓15份、泽泻20份、大腹皮15份、鳖甲20份、龟甲20份、山甲10份、乌蛇20份、甘草10份、冬虫夏草10份。
制备方法:
(1)按配方比称取各中药原料,将冬虫夏草研磨成粉,得冬虫夏草药粉,备用;
(2)将除冬虫夏草外的各中药原料加12倍量的水浸泡30min,之后药材与水一起倒入煎药锅中,武火煮沸后文火煎煮30min,过滤,得煎煮液一;之后再向煎药锅中加入9倍量的水,武火煮沸后文火煎煮25min,过滤,得煎煮液二;合并煎煮液一和煎煮液二,将冬虫夏草药粉加入到合并的煎煮液中,搅拌均匀,即得汤剂。
实施例2:本发明汤剂
原料药:茵陈24份、栀子15份、柴胡10份、半夏12份、白术10份、木香15份、丹参12份、藏红花8份、荆三棱15份、龙胆草8份、茯苓18份、泽泻15份、大腹皮17份、鳖甲18份、龟甲18份、山甲12份、乌蛇18份、甘草15份、冬虫夏草8份。
制备方法:
(1)按配方比称取各中药原料,将冬虫夏草研磨成粉,得冬虫夏草药粉,备用;
(2)将除冬虫夏草外的各中药原料加10倍量的水浸泡20min,之后药材与水一起倒入煎药锅中,武火煮沸后文火煎煮40min,过滤,得煎煮液一;之后再向煎药锅中加入7倍量的水,武火煮沸后文火煎煮20min,过滤,得煎煮液二;合并煎煮液一和煎煮液二,将冬虫夏草药粉加入到合并的煎煮液中,搅拌均匀,即得汤剂。
实施例3:本发明散剂
原料药:茵陈22份、栀子11份、柴胡14份、半夏11份、白术11份、木香14份、丹参14份、藏红花11份、荆三棱11份、龙胆草11份、茯苓14份、泽泻22份、大腹皮14份、鳖甲19份、龟甲21份、山甲11份、乌蛇19份、甘草12份、冬虫夏草9份。
制备方法:
(1)按配方比称取各原料药;
(2)然后将各原料药进行粉碎,过120目筛,最后将各原料药细粉混匀,即得。
实施例4:本发明片剂
原料药:茵陈16份、栀子15份、柴胡10份、半夏8份、白术15份、木香10份、丹参18份、藏红花12份、荆三棱10份、龙胆草12份、茯苓12份、泽泻25份、大腹皮17份、鳖甲18份、龟甲22份、山甲12份、乌蛇18份、甘草15份、冬虫夏草8份。
制备方法:
(1)按配方比称取各原料药,将冬虫夏草研磨成粉,得冬虫夏草药粉,备用;
(2)将除冬虫夏草外的各中药原料加10倍量的水煎煮1h,收集滤液,如此反复3次,合并所有滤液,过滤,弃去残渣,得提取液,将所述提取液于70℃下浓缩成相对密度为1.15的稠膏,加入冬虫夏草药粉并混匀,喷雾干燥得中药提取物粉体;
(3)将上述中药提取物粉体中加入淀粉、糊精适量,混匀,用5%PVP溶液制成颗粒,加入适量羧甲基纤维素钠、硬脂酸镁,混匀,压片,即得。
实施例5:本发明颗粒剂
原料药:茵陈20份、栀子12份、柴胡10份、半夏12份、白术12份、木香12份、丹参18份、藏红花8份、荆三棱10份、龙胆草12份、茯苓12份、泽泻20份、大腹皮15份、鳖甲18份、龟甲22份、山甲8份、乌蛇22份、甘草10份、冬虫夏草12份。
制备方法:
(1)按配方比称取各原料药,将冬虫夏草研磨成粉,得冬虫夏草药粉,备用;
(2)将除冬虫夏草外的各中药原料加10倍量的水煎煮1h,收集滤液,如此反复3次,合并所有滤液,过滤,弃去残渣,得提取液,将所述提取液于70℃下浓缩成相对密度为1.20的稠膏,加入冬虫夏草药粉并混匀,喷雾干燥得中药提取物粉体;
(3)将上述中药提取物粉体中加入淀粉、糊精适量,加入蔗糖、糊精适量,混匀,用75%乙醇造成软材,过12-14目筛制成颗粒,干燥,分装,即得。
实施例6:本发明胶囊剂
原料药:茵陈18份、栀子13份、柴胡11份、半夏9份、白术13份、木香11份、丹参16份、藏红花9份、荆三棱14份、龙胆草9份、茯苓16份、泽泻18份、大腹皮16份、鳖甲21份、龟甲19份、山甲9份、乌蛇21份、甘草8份、冬虫夏草11份。
制备方法:
(1)按配方比称取各原料药,将冬虫夏草研磨成粉,得冬虫夏草药粉,备用;
(2)将除冬虫夏草外的各中药原料加10倍量的水煎煮1h,收集滤液,如此反复3次,合并所有滤液,过滤,弃去残渣,得提取液,将所述提取液于70℃下浓缩成相对密度为1.15的稠膏,加入冬虫夏草药粉并混匀,喷雾干燥得中药提取物粉体;
(3)将上述中药提取物粉体中加入淀粉、糊精适量,混匀,用5%PVP溶液制成颗粒,加入适量硬脂酸镁,混匀,装胶囊,即得胶囊剂。
实施例7:本发明丸剂
原料药:茵陈16份、栀子10份、柴胡15份、半夏8份、白术15份、木香10份、丹参18份、藏红花12份、荆三棱10份、龙胆草12份、茯苓12份、泽泻25份、大腹皮13份、鳖甲22份、龟甲22份、山甲8份、乌蛇22份、甘草6份、冬虫夏草12份。
制备方法:
(1)按配方比称取各原料药;
(2)然后将各原料药进行粉碎,过140目筛,最后将各原料药细粉混匀,得混合药粉,以炼蜜为黏合剂,制成蜜丸。
以上为对本发明实施例的描述,通过对所公开的实施例的上述说明,使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的,本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下,在其它实施例中实现。因此,本发明将不会被限制于本文所示的这些实施例,而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。
Claims (8)
1.一种治疗病毒性肝炎、肝纤维化的中药组合物,其特征在于,由以下重量份的原料制成:茵陈16-24份、栀子10-15份、柴胡10-15份、半夏8-12份、白术10-15份、木香10-15份、丹参12-18份、藏红花8-12份、荆三棱10-15份、龙胆草8-12份、茯苓12-18份、泽泻15-25份、大腹皮13-17份、鳖甲18-22份、龟甲18-22份、山甲8-12份、乌蛇18-22份、甘草6-15份、冬虫夏草8-12份。
2.根据权利要求1所述的中药组合物,其特征在于,由以下重量份的原料制成:茵陈18-22份、栀子11-13份、柴胡11-14份、半夏9-11份、白术11-13份、木香11-14份、丹参14-16份、藏红花9-11份、荆三棱11-14份、龙胆草9-11份、茯苓14-16份、泽泻18-22份、大腹皮14-16份、鳖甲19-21份、龟甲19-21份、山甲9-11份、乌蛇19-21份、甘草8-12份、冬虫夏草9-11份。
3.根据权利要求2所述的中药组合物,其特征在于,由以下重量份的原料制成:茵陈20份、栀子12份、柴胡12份、半夏10份、白术12份、木香12份、丹参15份、藏红花10份、荆三棱12份、龙胆草10份、茯苓15份、泽泻20份、大腹皮15份、鳖甲20份、龟甲20份、山甲10份、乌蛇20份、甘草10份、冬虫夏草10份。
4.一种治疗病毒性肝炎、肝纤维化的中药制剂,其特征在于,所述中药制剂为含有如权利要求1-3任一项所述的中药组合物的中药制剂。
5.根据权利要求4所述的中药制剂,其特征在于,所述制剂为汤剂、散剂、片剂、胶囊剂或丸剂。
6.根据权利要求5所述的中药制剂,其特征在于,所述制剂为汤剂。
7.根据权利要求6所述的中药制剂的制备方法,其特征在于,包括以下步骤:
(1)按配方比称取各中药原料,将冬虫夏草研磨成粉,得冬虫夏草药粉,备用;
(2)将除冬虫夏草外的各中药原料加10-12倍量的水浸泡20-30min,之后药材与水一起倒入煎药锅中,武火煮沸后文火煎煮30-40min,过滤,得煎煮液一;之后再向煎药锅中加入7-9倍量的水,武火煮沸后文火煎煮20-25min,过滤,得煎煮液二;合并煎煮液一和煎煮液二,将冬虫夏草药粉加入到合并的煎煮液中,搅拌均匀,即得汤剂。
8.根据权利要求1-3任一项所述的中药组合物在制备治疗病毒性肝炎和肝纤维化的药物中的应用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711287592.XA CN108159222A (zh) | 2017-12-07 | 2017-12-07 | 一种治疗病毒性肝炎、肝纤维化的中药组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711287592.XA CN108159222A (zh) | 2017-12-07 | 2017-12-07 | 一种治疗病毒性肝炎、肝纤维化的中药组合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108159222A true CN108159222A (zh) | 2018-06-15 |
Family
ID=62524595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711287592.XA Pending CN108159222A (zh) | 2017-12-07 | 2017-12-07 | 一种治疗病毒性肝炎、肝纤维化的中药组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108159222A (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1698877A (zh) * | 2005-06-06 | 2005-11-23 | 赵新德 | 虫草养肝胶囊 |
US7320805B2 (en) * | 2003-10-01 | 2008-01-22 | Institut National De La Sante Et De La Recherche Medicale | CB2 receptors blocks accumulation of human hepatic myofibroblasts: a novel artifibrogenic pathway in the liver |
-
2017
- 2017-12-07 CN CN201711287592.XA patent/CN108159222A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7320805B2 (en) * | 2003-10-01 | 2008-01-22 | Institut National De La Sante Et De La Recherche Medicale | CB2 receptors blocks accumulation of human hepatic myofibroblasts: a novel artifibrogenic pathway in the liver |
CN1698877A (zh) * | 2005-06-06 | 2005-11-23 | 赵新德 | 虫草养肝胶囊 |
Non-Patent Citations (1)
Title |
---|
杨鹏等: "加味茵陈蒿汤治疗急性病毒性肝炎68例", 《甘肃中医》 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101618155B (zh) | 一种治疗口腔粘膜病的药物 | |
CN101884776B (zh) | 一种治疗手足口病的中药制剂 | |
CN101502588B (zh) | 一种美容祛痘组合物及其制备方法 | |
CN103623358A (zh) | 一种治疗急、慢性咽炎的中药汤剂 | |
CN104524337A (zh) | 一种治疗口腔溃疡的中药 | |
CN103007062B (zh) | 一种治疗脑血栓的中药方剂 | |
CN105535390A (zh) | 一种治疗冠心病的中药汤剂及其制备方法 | |
CN105663980A (zh) | 一种治疗慢性胃炎的新型中药组合物及制备方法 | |
CN105497439A (zh) | 一种治疗妇产科术后低热症的药物组合物 | |
CN104922426A (zh) | 一种治疗妇产科术后低热症的药物组合物 | |
CN101912506A (zh) | 一种治疗慢性结肠炎的中药制剂 | |
CN107715014A (zh) | 一种用于痛风的中药组合物及其制备方法 | |
CN103463566A (zh) | 一种治疗慢性支气管炎的中药组合物 | |
CN105688006A (zh) | 一种治疗半身不遂的中药组合物及其制备方法 | |
CN104873828A (zh) | 一种治疗放射性皮肤损伤的中药制剂及其制备方法 | |
CN103432482A (zh) | 一种用于治疗痤疮的中药组合物及其制剂的制备方法 | |
CN105535855A (zh) | 一种治疗乙型肝炎的中药组合物及其制备方法 | |
CN108159222A (zh) | 一种治疗病毒性肝炎、肝纤维化的中药组合物 | |
CN104623135A (zh) | 治疗肝火上炎的药物及其口服微丸的制备方法 | |
CN103610934A (zh) | 一种治疗咽炎的中药 | |
CN103784720A (zh) | 一种降血糖尿糖的中药制剂 | |
CN103432422B (zh) | 一种治疗慢性胃炎的中药 | |
CN107854633A (zh) | 治疗痛风的组合物及其制备方法 | |
CN102406913A (zh) | 一种治疗郁证的中药组合物 | |
CN105250618A (zh) | 一种治疗肝硬化的抗病毒中药组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20190122 Address after: 2003 3rd Floor, 323 Guoding Road, Yangpu District, Shanghai Applicant after: Shanghai Kazhi Biotechnology Co., Ltd. Address before: Room 3207A, Building No. 200, Zhangheng Road, Pudong New Area, Shanghai Applicant before: Card (Shanghai) biotechnology Limited by Share Ltd |
|
TA01 | Transfer of patent application right | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180615 |
|
RJ01 | Rejection of invention patent application after publication |