CN1080971A - A kind of antibiotic, fabric and its production and application of sterilizing - Google Patents
A kind of antibiotic, fabric and its production and application of sterilizing Download PDFInfo
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Abstract
The invention discloses a kind of antibiotic, sterilize fabric and the cloudy washing lotion of Shu Er, this washing lotion comprises the coptis, golden cypress, kuh-seng, frutus cnidii, folium isatidis, the root of Dahurain angelica etc., effect is clearing heat and detoxicating, killing parasites to relieve itshing, expelling wind and removing dampness, vaginitis, vulvitis and venereal disease and skin disease there is special efficacy, produce effects is more than 83.8%, effective more than 95%, can use for men and women, old and young patient.
Description
The invention relates to a kind of fabric, more particularly about a kind of antibiotic, fabric and its production and application of sterilizing.
By mould, trichomonad, bacterial vaginitis, vulvitis etc. is the common disease and the frequently-occurring disease of gynaecology, has a strong impact on numerous women's health.Surplus in the of nearly in addition 10 year, once once revivable again, and be spreading trend in the venereal disease of China's disappearance, and in the venereal disease based on the gonorrhoea due to the gonococcus, account for about 80% of the venereal disease incidence of disease.In addition, summer dermatitis, wet examine, the illness rate and the recurrence rate of pruritus dermatopathies such as papular urticaria, impetigo skin and candidiasis of the genitals be also very high, the patient suffers untold misery, influence study seriously, work and life.Though have some to treat the chemicals of above-mentioned disease, therapeutic domain is narrower, and very easily produces drug resistance and allergic reaction, these chemicalss can not make its application be subjected to certain restriction as prophylactic in addition.
One of purpose of the present invention is a kind of antibiotic, sterilization fabric of development.
Two of purpose of the present invention is that pruritus dermatopathy, the washing lotion of vaginitis and venereal disease can be treated and prevent to development a kind ofly effectively.
Three of purpose of the present invention is preparation methods of a kind of washing lotion of development.
These and other objects of the present invention will embody further and illustrate by following specific descriptions and explanation.
The present invention is following composition for washing lotion comprises: the yellow Cen of the 5-20g coptis, 2-10g golden cypress, 8-18g kuh-seng, 5-25g frutus cnidii, 5-20g tarragon, 10-15g levisticum, 4-16g rhizoma atractylodis, 1-8g, 10-17g folium isatidis, the 2-20g fruit of summer cypress, 2-8g bacterium are old, 7-12g cape jasmine, 1-6g peppermint, 2-8g Chinese prickly ash, 10-20g subprostrate sophora, 4-10g honeysuckle, the 1-8g Chinese bulbul, the 2-6g bark of ash, the 1-6g root of Dahurain angelica, 2-8g Golden Larch Bark, adding water to total liquid measure is 1000ml.
Be preferably that washing lotion of the present invention comprises that the yellow Cen of the 6-15g coptis, 3-8g golden cypress, 10-16g kuh-seng, 8-20g frutus cnidii, 8-18g tarragon, 10-15g levisticum, 6-14g rhizoma atractylodis, 2-7g, 11-16g folium isatidis, the 4-18g fruit of summer cypress, 2-8g bacterium are old, 7-11g cape jasmine, 2-6g peppermint, 2-8g Chinese prickly ash, 11-18g subprostrate sophora, 5-8g honeysuckle, the 2-7g Chinese bulbul, the 2-6g bark of ash, the 2-6g root of Dahurain angelica, 2-7g Golden Larch Bark, adding water to total liquid measure is 1000ml.
In the present invention, can use fabric, comprise that knitted fabric, woven fabric and bondedfibre fabric flood washing lotion and make antibiotic, sterilization fabric.Also can be directly with above-mentioned washing lotion washing human body.
In the present invention, except that medicinal material is arranged, the water of appropriate amount is arranged still, in general medicinal material is 1 with the ratio of water: 3-8 is preferably 1: 4-7, water can be used distilled water, deionized water or other clean water through sterilization, sterilization.
In the present invention, prepare soup by the following method:
Take by weighing medicinal material by formula ratio, make total amount reach 200kg, add water five times and soak into (putting in the multipotency extractor), logical steam was kept 0.7-1.5 hour to boiling, and was preferably 0.9 hour, collected extract; Add 4 times of water again and in jar, be fried boiling, keep half an hour, collect extract for the second time; Add water once more and go in the jar to be fried boiling for 3 times, continue 10-30 minute, collect extract for the third time; Carry out centrifugal removing slag after No. three the extract summations, filtrate is concentrated into proportion and is about 1.1-1.3 in inspissator, and in 1: 1-1: the alcohol that 3 ratio adds 90% above concentration precipitates, centrifugal once more removing slag, filtrate enters material-compound tank, regulates pH value to 4.5-6.0, is preferably 4.8-5.7; Add the initial volatile component of collecting, add proper amount of edible essence, add distilled water and adjust total amount to 1 ton, can carry out can.
For convenience of explanation, the applicant is called washing lotion of the present invention " the cloudy washing lotion of Shu Er ".
In the present invention, in soup, about 3-60 takes out after second and is antibiotic, sterilization fabric with textile impregnation.
In the present invention, the coptis, golden cypress are strong heat-clearing and damp-drying drug, the purging intense heat and detonicating medicine, external application can be washed and be controlled the suppurative of skin and mucosal sites and apyetous illness, no matter be bleb wetly mashedly, red itch, swollen.
Following, the pruritus vulvae of pain and band, damp and hot friendship knot of all genus or the dirty person of hot poisonous insect all can use.So as far back as Shennong's Herbal the coptis " (controlling) married woman swelling of vulva pain " is just arranged, " herbal diagram " also has " clearing damp heat and reason sore "; The record of golden cypress " (controlling) negative and positive phagedenoma " (" herbal classic ") and " (controlling) herpes simplex blister plays the worm sore " (supplement to the Herbal) etc.The property stick-slip of golden cypress decocting liquid wherein, external application washing or soak affected part make the patient also have moist, comfortable sense, are excellent than the coptis especially, so " surgery essential ideas " claims that " golden cypress master sore is swollen very refreshing.Zhu Fang makes soup, and it is good to wash the erosion of vulva ".The same usefulness of Erhuang can be encouraged curative effect mutually.The positive disease sore of the heat-clearing of kuh-seng energy, dehumidifying, desinsection, external application main treatment skin and mucous membrane, especially with treatment itch dermatopathy, scrotum eczema and outer dark and damp itching: " treat and dislike sore, bottom " for seeing, so just put down in writing far away from " Mingyi Bielu " more.Frutus cnidii can dispel pathogenic wind and remove dampness, killing parasites to relieve itshing, and external application cures mainly that cysthus wet is itched, wet sore, pruritus ani and itch dermatopathy, and normal and golden cypress, kuh-seng are equal to usefulness.So Shennong's Herbal carries: " main man's the moon withers to wet and itches pain in married woman's the moon "." book on Chinese herbal medicine is just " also has: " allly control outer disease itch and swell and ache, the wind sore, all suitable soup is smoked and is washed ".
Folium isatidis can be clearing heat and detoxicating, but the red and swollen heat of washout skin and mucous membrane is itched or wet rotting; The Chinese bulbul can heat-clearing and damp-drying drug be ended band, but the bathing damp-heat vaginal discharge; The root of Dahurain angelica is used for the itch dermatopathy outward, can not only dispel pathogenic wind and remove dampness, but and skin moistening and itch stopping, swelling and pain relieving.
In addition, pericarpium zanthoxyli is used for mucocutaneous various infringements outward, the effect that all has pain relieving to itch, no matter to because of heat, because of wet, because of wind, because of the sufferings of worm, sufferings are alleviated, so all reuse it in " surgery great achievement " " controlling all sores of itching stands ".
Take a broad view of full side, be made as washing lotion, in order to lavation vagina, vulva or soak skin affected part, both can directly act on the part, can absorb by local mucous membrane again, to change the human internal environment, so the treatment vaginitis is (according to clinical report, applicable to mycotic, bacillary, trichomonad property and senile vahinitis), the itch dermatosis, all have certain good efficacy.
The Pharmacodynamic test of active extract of " Shu Eryin "
(commercially available JIEERYIN contrast is selected in this experiment for use)
1, to gonococcal inhibitory action:
Record gonococcal inhibitory action: t check by paper disk method: two groups of medicines were same concentrations (1: 2000,0.5mg crude drug/ml), " Shu Eryin " group inhibition zone (20 ± 2.1mm) with " JIEERYIN " group (positive control drug group) inhibition zone (8 ± 1.5mm) contrast, difference has highly significant meaning (p＜0.01).X
2Test: by with inhibition zone 10-17mm(medium sensitivity) and above positive, two medicines same concentrations (1: 2000,0.5mg crude drug/ml), the number positive of " Shu Eryin " group totally 20 accounts for 100%; The number positive only 1 of " JIEERYIN " group accounts for 0.5%, through X
2Test, two groups positive percentage difference has highly significant meaning (p＜0.001).
Record gonococcal MIC(minimum inhibitory concentration by the rare method of culture medium): " Shu Eryin " washing lotion concentration in proportion is calculated as 1: 4000, is calculated as 0.25mg/ml by the medicinal material dry product." JIEERYIN " washing lotion (positive control drug) concentration is in proportion counted 1: 800, is calculated as 1.25mg/ml by the medicinal material dry product.
Therefore " Shu Eryin " washing lotion has strong the inhibition and killing action to gonococcus, and obviously is better than " JIEERYIN " washing lotion.
2, to vagina mould and colibacillary inhibitory action:
(1) by paper disk method: to colibacillary inhibitory action: two groups of medicines were same concentrations (1: 2000,0.5mg crude drug/ml), " Shu Eryin " group inhibition zone (21 ± 2.9mm) with " JIEERYIN " group inhibition zone (5.7 ± 1.1mm) contrast, difference has highly significant meaning (p＜0.001).And the number positive (in quick above bacterial strain number) of " Shu Eryin " group totally 20 accounts for 100%; The number positive of " JIEERYIN " group is 0.Two groups positive percentage difference has highly significant meaning (p＜0.001).
Inhibitory action to the vagina mould: two groups of medicines were same concentrations (1: 1800,0.56mg crude drug/ml), " Shu Eryin " group the inhibition circle (19.5 ± 4.4mm) with " JIEERYIN " group inhibition zone (7.5 ± 1.88mm) contrast, difference has highly significant meaning (p＜0.001).And positive rate (10%) contrast of the positive (more than the medium sensitivity bacterial strain) rate 95% of " Shu Eryin " group and " JIEERYIN " group, difference has highly significant meaning (p＜0.001).
(2) by media dilution method: " Shu Eryin " washing lotion is to colibacillary MIC, and concentration is calculated as 1: 4000 in proportion, is calculated as 0.25mg/ml by the medicinal material dry product; To the MIC of vagina mould, concentration is calculated as 1: 1800 in proportion, is calculated as 0.56mg/ml by the medicinal material dry product." JIEERYIN " washing lotion is to colibacillary MIC, and concentration is calculated as 1: 500 in proportion, is calculated as 2mg/ml by the medicinal material dry product.To vagina mould and MIC, concentration is calculated as 1: 900 in proportion, is calculated as 1.12mg/ml with the medicinal material dry product.
Experimental data shows that " Shu Eryin " lotion has stronger inhibition and killing action to vagina mould and Escherichia coli, and obviously is better than " JIEERYIN " washing lotion.
3, to the inhibitory action of Trichomonas vaginalis:
" Shu Eryin " washing lotion is pressed the medicinal material dry product and is calculated, and is 1.25mg/ml to the minimum inhibitory concentration of Trichomonas vaginalis, (concentration is calculated as 1: 800 in proportion).Compare with the positive control drug metronidazole, " Shu Eryin " roughly is equivalent to inhibition concentration 2～3 μ g/mls of metronidazole to Trichomonas vaginalis to inhibition concentration 2～3mg/ml of Trichomonas vaginalis.As seen " Shu Eryin " washing lotion has obvious suppression and killing action to Trichomonas vaginalis.
The toxicology test of " Shu Eryin "
1, irritate the acute toxicity testing that stomach absorbs: through the mouse stomach administration, dosage was observed 7 days up to 20mg/kg, did not still have poisoning symptom and dead the generation, and through gross necropsy, each organs and tissues outward appearance all belongs to normally.So " Shu Eryin " washing lotion is nontoxic safe preparation.
2, through the toxicity test of skin absorbs: adopt mouse tail soaking test method.Mouse was soaked " Shu Eryin " washing lotion of tail 10-80% concentration in continuous 7 days, and each activity, breathing, heart rate, secretion and ight soil etc. of organizing mouse does not all have influence, does not see poisoning symptom, none death.Through gross necropsy, each internal organs group outward appearance no abnormality seen.As seen test sample " Shu Eryin " lotion 10-80% does not cause general toxic reaction hardly through skin absorbs.
3, to the irritant experiment of rabbit skin: with 10%, 20%, 40%, " Shu Eryin " of 80% 4 kind of concentration, adopt " patch method " to observe irritative response relevant with dosage at the complete sum damaged skin of rabbit." Shu Eryin " washing lotion of four kinds of variable concentrations of experimental result is to most normal skins or damaged skin nonirritant all, and only indivedual rabbit skins have the minimal irritation reaction.But relatively do not have marked difference with control group, do not have the related stimulus reaction of dosage or concentration yet.As seen " Shu Eryin " washing lotion of 10-80% is to the skin nonirritant.
4, to the stimulation of rabbit vagina and local toxicity experiment: " Shu Eryin " 40%, 20%, 10% 3 kind of concentration and physiological saline contrast, every day is carried out vagina in the grouping of the doe of not mating keep somewhere lavation, every group is further divided into continuous medicine-filling and organized mutually three the time in 5 days, 10 days, 20 days simultaneously.Each treated animal at first carries out gross anatomy and perusal after living and killing, and gets vagina and cervix subsequently and carries out pathological section and optical frames observation.Through perusal, the heart of each rabbit, lung, liver,spleen,kidney, vagina, uterus and fallopian tube there is no unusual.Histopathologic slide is observed through optical frames, interior mutually most of animals had in various degree hyperemia and oedema when each organized with each, all slighter, compare there was no significant difference with physiological saline, inflammatory cell is classified, and observing its infiltration amount, its result and control group are learned more by statistics to handle and are shown, alternate also there was no significant difference when reaching each between each group.
Experimental result shows, " Shu Eryin " washing lotion is under up to 40% concentration 5ml/kg/d dosage, and continuous 20 days vaginas are kept somewhere perfusion is not still had obvious irritation and local toxic reaction, and the 50-100 that this dosage surpasses the clinical practice consumption doubly.This washing lotion is safe, a nontoxic preparation really.
5, the sensitization of guinea pig skin is tested: adopt " patch method " " Shu Eryin ", carry out the cutaneous anaphylaxis experiment in five stages (12 days * 5) in five test blocks of guinea pig back skin with 10% concentration.The experiment (being coated with soup) in five zones of 10 cavys and contrast position skin color are all more ruddy, and difference is not seen in both sides, and the epidermis profile is phenomenon such as swollen, the ulcer of water breakthrough not also.The and arranged on left and right sides skin temperature fluctuation of five-stage experimental session all in normal range (NR), is learned by statistics and is handled no significant difference.As seen the external application of " Shu Eryin " lotion can not cause allergic reaction.
Four, " Shu Eryin " treatment vaginitis and pruritus dermatopathy clinical observation final report
(selecting for use commercially available JIEERYIN to make positive control drug)
This test is specified by Affiliated Hospital of Chengdu College of Traditional Chinese Medicine, the 3rd affiliated hospital of Third Military Medical University, the common cooperation of Chengdu The Second People Hospital through Department of Public Health of Shanxi Province and is carried out clinical testing.Three hospitals are in strict accordance with clinical trial protocol, follow contrast, (treatment group and control group use clean safe liquid A and clean safe liquid B respectively with the principle of double blinding at random.A liquid is the cloudy washing lotion of medicine Shu Er; B liquid is commercially available JIEERYIN XIYE, and both packings and outward appearance are in full accord).Objective evaluation is carried out in effect and security to cloudy washing lotion treatment vaginitis of Shu Er and pruritus dermatopathy.This test case diagnostic criteria scorching with reference to " new drug (Chinese medicine) clinical research guideline " medial vagina and pruritus dermatopathy is observed vaginitis 217 examples altogether, and pruritus dermatopathy 248 examples now are summarized as follows result of the test:
(1) treatment vaginitis clinical testing: vaginitis 217 examples are observed in this test altogether, wherein, and the cloudy treatment of Shu Er 142 examples, JIEERYIN control group 75 examples.Two groups of cases are learned by statistics and are handled there was no significant difference aspect constituent ratios such as age, the course of disease, traditional Chinese and western medicine somatotype, severity extent and main disease.Two groups of cases all are mixed with 10% concentration with former medicine and carry out vagina and vulva flushing, every day 1 time, logotype 7 days.Draft efficacy assessment standard by " new drug (Chinese medicine) clinical research guideline " treatment by Chinese herbs female sex organs system inflammation content, treatment results is summarized as follows:
1, the colpitic obvious effective rate of the cloudy treatment of total effects evaluation: Shu Er is 83.8%, total effective rate 90.1%; The obvious effective rate of JIEERYIN control group is 58.7%, total effective rate 72.0%, and learning by statistics to handle has significant difference (P＜0.01).The curative effect of the cloudy treatment group of Shu Er obviously is better than the JIEERYIN control group, and wherein, to nonspecific vaginitis and senile vahinitis curative effect the best, the obvious effective rate of the cloudy treatment group of Shu Er reaches 95.3%, and the JIEERYIN control group only is 57.1%; Remarkable to the colpomycosis effect, the obvious effective rate of the cloudy treatment group of Shu Er reaches 90.8%, and the JIEERYIN control group is that 65.5%, two group obvious effective rate contrast all has significant differences (P＜0.001 and P＜0.01).Poor slightly to the trichomonas vaginitis effect, the obvious effective rate of the cloudy treatment group of Shu Er is 55.9%; The JIEERYIN control group is 50.0%, two group of relatively there was no significant difference (P＞0.05).
2, severity extent and curative effect of medication analysis: to the severe vaginitis, the obvious effective rate of the cloudy treatment group of Shu Er is 81.9%, and the obvious effective rate of JIEERYIN control group is 50.5%.Two groups of contrasts have significant differences (P＜0.01), to the moderate vaginitis, the obvious effective rate of the cloudy group of Shu Er is 83.9%, with obvious effective rate 64.5% contrast of JIEERYIN group significant difference (P＜0.05) is arranged, and shows that Shu Er the moon obviously is better than JIEERYIN to severe and moderate vaginitis patient's curative effect.Two groups to slight vaginitis obvious effective rate there was no significant difference.
3, disease curative effect: to cardinal symptom and sign, carry out efficacy evaluation as variations such as abnormal leucorrhea, pruritus vulvae, the red and swollen cusalgia of private parts, urinary tract infection symptoms, the result shows: the cloudy treatment group of Shu Er relatively has significant differences (P＜0.01) to the cure rate of symptoms such as abnormal leucorrhea, vulvovaginal cusalgia, itch, urinary tract symptom, intercourse pain, vulvovaginal redness with the JIEERYIN control group; To improving the pain of lower abdomen, pain in the back there was no significant difference (P＞0.05).
4, the variation of test rating: Shu Er the moon is to colpitic leukorrhea smear and to cultivate positive negative conversion rate be 85.9%; To vagina cleanness degree 〉=III
0Negative conversion rate 73.0%, the negative conversion rate of JIEERYIN contrast medicine is respectively 70.7% and 49.0%.Two groups of negative conversion rate contrasts have significant differences (P＜0.001).
Shu Er the moon is the colpitic pure Chinese medicinal preparation of treatment.Be used for vulvovaginal flushing, the treatment vaginitis is evident in efficacy, nonspecific vaginitis, colpomycosis are had better effect, do not find any bad reaction in the clinical testing, with after comfort be known as its advantage by the patient, and it is easy to use, be a colpitic desirable new drug of treatment, be worthy of popularization.
(2) clinical testing of treatment pruritus dermatopathy: pruritus dermatopathy 248 examples are observed in this test altogether, wherein 138 examples are organized in the cloudy treatment of Shu Er, JIEERYIN control group 110 examples, two groups of cases are learned by statistics and are handled there was no significant difference aspect formations such as sex, age, the course of disease, disease type, severity extent.
1, curative effect determinate standard, recovery from illness: gargalesthesia disappears, and skin decreases and disappears fully; Produce effects: gargalesthesia obviously alleviates, and skin decreases and disappears more than 60%; Effectively: gargalesthesia alleviates, and skin decreases the 20-30% that disappears; Invalid: gargalesthesia ditto or more violent, skin decreases and disappears less than 20% or increase the weight of.
2, methods of treatment, two groups of cases are all decreased the character decision according to skin, and skin decreases the erosion person of oozing out, and with warm boiling water soup is diluted 10 times of soak affected parts, every day 3～4 times, each about 2 hours; The dryness skin decreases and puts on the skin outward with former medicine, and the perineal position skin decreases with warm boiling water the soup dilution is put on the skin outward for 10 times, and every day 2～4 times, 3 days is a course of treatment, treats two courses of treatment altogether.
3, total effects evaluation, the obvious effective rate of the cloudy treatment of Shu Er pruritus dermatopathy is 74.6%, total effective rate is 92.1%; The obvious effective rate of JIEERYIN treatment of control group pruritus dermatopathy is 50.0%, total effective rate is 77.8%, contrast between the obvious effective rate of two groups of curative effects and total effective rate, significant differences (P＜0.001) is all arranged, Shu Er the moon obviously is better than JIEERYIN to the curative effect of pruritus dermatopathy, especially the obvious effective rate to papular urticaria is 79.3%, and total effective rate is 94.3%; The obvious effective rate of JIEERYIN is 51.2%, total effective rate is 79.1%, two groups of contrasts differ highly significant (P＜0.01), to summer dermatitis, the obvious effective rate of Shu Er the moon is 78.6%, with 42.1% contrast of JIEERYIN obvious effective rate, differs remarkable (P＜0.05) to impetigo and skin and candidiasis of the genitals, the obvious effective rate of the cloudy treatment group of Shu Er is respectively 85.7% and 91.7%, far above the obvious effective rate (being respectively 54.5% and 66.7%) of control drug JIEERYIN.
4, the relation of curative effect and disease type relatively: the cloudy treatment group of Shu Er all has curative effect preferably to the wind-heat of five kinds of diseases such as papular urticaria, damp and hot, hot toxication type, compare with the JIEERYIN control group, the obvious effective rate of wind-heat, damp-heat type is had the difference of conspicuousness and highly significant.
5, Chengdu-Chongqing two places treatment checking result: the obvious effective rate (being respectively 76.0% and 74.6%) of the cloudy treatment group of Chengdu-Chongqing two places Shu Er is all far above JIEERYIN control group (being respectively 46.8% and 47.6%), learn by statistics and handle, P value difference＜0.01 and P＜0.001 differ highly significant.
6, two groups of side effect incidences relatively: no matter outer the treatment group puts on the skin, soak or bathing, and its side effect (incidence is 2.2%) is all extremely slight, and incidence is starkly lower than control group (incidence is 8.2%), and mostly is one and crosses the property discomfort, need not handle.
According to clinical test results, show that the cloudy washing lotion of Shu Er is a safety, curative effect external used medicine higher, easy to use, be worth of widely use.
Washing lotion of the present invention is by following usage, and consumption uses:
1, gynecological disease: get 20-30ml, the boiling water of heating is diluted to 200-300ml at every turn, and in the syringe of packing into, washing vagina was kept somewhere 5 minutes.Also available band line absorbent cotton soaks soup and fills in vagina.Every day 1 time, 7 days one courses of treatment of logotype.Prohibit sexual life during the treatment, the underpants sheet is scalded.
2, skin disease: skin is decreased rotten to the corn sepage person, get this product and be diluted to 10 times with warm boiling water, the soak affected part; Skin is decreased dryness person, directly be coated with former washing lotion and put affected part on the skin, every day 2-4 time, 3 is a course of treatment.
3, the clean health care of male and female pudendum: be diluted to 10-50 doubly with this product, bathing private parts or hip bath.
In the present invention, if not refer in particular to all amounts, part is unit of weight.All raw material, equipment all are commercially available.
Below further specify the present invention by specific embodiment.But embodiment only is used for explanation, can not limit the scope of the invention.
Example 1, prescription: the yellow Cen of the 5kg coptis, 3kg golden cypress, 8kg kuh-seng, 25kg frutus cnidii, 15kg tarragon, 10kg levisticum, 10kg rhizoma atractylodis, 4kg, 10kg folium isatidis, the 20kg fruit of summer cypress, 8kg bacterium are old, 7kg cape jasmine, 3kg peppermint, 4kg Chinese prickly ash, 20kg subprostrate sophora, 4kg honeysuckle, the 4kg Chinese bulbul, the 2kg bark of ash, the 3kg root of Dahurain angelica, 8kg Golden Larch Bark.
Method: the water infiltration (putting in the multipotency extractor) that adds five times of above-mentioned medicinal material weight, logical steam is to boiling, kept 1 hour, collect extract, adding the decocting of stating four times of medicinal material weight boils, keep half an hour, collect extract for the second time, the water that adds triplication again goes in the jar to be fried boiling, kept 15 minutes, collect extract for the third time, No. three extracts add centrifugation together and remove slag, filtrate is concentrated into proportion in inspissator be 1: 1, and the alcohol (95%) that adds 1.2 times of volumes precipitates, centrifugal once more removing slag, filtrate enters material-compound tank, and regulating PH is that 5.8(is with sour), add the initial volatile ingredient of collecting; Add an amount of essence, adding distil water transfers to five times of weights that total amount is initial medicinal material amount, gets final product can.
Example 2 is got above-mentioned washing lotion 50g, soaks into hospital gauze, puts into vagina, the treatment vaginitis.
Example 3, prescription:
The bitter machine tool of the 20kg coptis, 10kg golden cypress, 15kg kuh-seng, 20kg, 15kg tarragon, 15kg levisticum, 12kg rhizoma atractylodis, the yellow Cen of 8kg, 17kg folium isatidis, the 15kg fruit of summer cypress, 6kg bacterium are old, 10kg cape jasmine, 5kg peppermint, 5kg Chinese prickly ash, 20kg subprostrate sophora, 5kg honeysuckle, the 6kg Chinese bulbul, the 6kg bark of ash, the 6kg root of Dahurain angelica, 8kg Golden Larch Bark.
Process is with example 1.
Example 4, prescription is with example 3.
Removing in the process and concentrating proportion is 1.17, adds 95% alcohol of 1.05 times of volumes, and PH is outside 5.6, and all the other are with example 1.
This professional those of ordinary skill can be made multiple change according to content disclosed by the invention, for example many several flavors or few a few flavor medicines, and dosage increases or reduces, and all should understand within the scope of the invention, is subjected to the restriction of claim of the present invention.
Claims (5)
1, a kind of antibiotic, the sterilization fabric, it is characterized in that except that comprising fabric, the 5-20g coptis, 2-10g golden cypress, 8-18g kuh-seng, 5-25g frutus cnidii also can be arranged on fabric, the yellow Cen of 5-20g tarragon, 10-15g levisticum, 4-16g rhizoma atractylodis, 1-8g, 10-17g folium isatidis, the 2-20g fruit of summer cypress, 2-8g bacterium are old, 7-12g cape jasmine, 1-6g peppermint, 2-8g Chinese prickly ash, 10-20g subprostrate sophora, 4-10g honeysuckle, the 1-8g Chinese bulbul, the 2-6g bark of ash, the 1-6g root of Dahurain angelica, 2-8g Golden Larch Bark, adding water to total liquid measure is 1000ml.
2, antibiotic, sterilization fabric as claimed in claim 1, it is characterized in that except that comprising fabric, can have also preferably on fabric that the yellow Cen of the 6-15g coptis, 3-8g golden cypress, 10-16g kuh-seng, 8-20g frutus cnidii, 8-18g tarragon, 10-15g levisticum, 6-14g rhizoma atractylodis, 2-7g, 11-16g folium isatidis, the 4-18g fruit of summer cypress, 2-8g bacterium are old, 7-11g cape jasmine, 2-6g peppermint, 2-8g Chinese prickly ash, 11-18g subprostrate sophora, 5-8g honeysuckle, the 2-7g Chinese bulbul, the 2-6g bark of ash, the 2-6g root of Dahurain angelica, 2-7g Golden Larch Bark, adding water to total liquid measure is 1000ml.
3, the preparation antibiotic, the sterilization fabric method, it is characterized in that at first preparing soup, then with textile impregnation in soup, about 3-60 takes out after second and gets final product.
4, preparation as claimed in claim 3 antibiotic, the sterilization fabric method, it is characterized in that preparing as follows soup:
Take by weighing medicinal material 200kg by formula ratio, add water five times and soak into (putting in the multipotency extractor), logical steam was kept 0.7-1.5 hour to boiling, and was preferably 0.9 hour, collected extract; Add 4 times of water again and in jar, be fried boiling, keep half an hour, collect extract for the second time; Add water once more and go in the jar to be fried boiling for 3 times, continue to collect in 10-30 minute extract for the third time; Carry out centrifugal removing slag after No. three the extract summations, filtrate is concentrated into proportion and is about 1.1-1.3 in inspissator, and in 1: 1-1: the alcohol that 3 ratio adds 90% above concentration precipitates, centrifugal once more removing slag, filtrate enters material-compound tank, regulates pH value to 4.5-6.0, is preferably 4.8-5.7; Add the initial volatile component of collecting, add proper amount of edible essence, adding distil water is adjusted total amount to 1 ton, can carry out can.
5, use as pruritus dermatopathy, vaginitis and venereal disease can be treated and prevent to claim 1,2 described antibiotic, the fabrics of sterilizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93108642 CN1031174C (en) | 1993-07-19 | 1993-07-19 | Bactericidal fabric, its producing method and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93108642 CN1031174C (en) | 1993-07-19 | 1993-07-19 | Bactericidal fabric, its producing method and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1080971A true CN1080971A (en) | 1994-01-19 |
| CN1031174C CN1031174C (en) | 1996-03-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93108642 Expired - Fee Related CN1031174C (en) | 1993-07-19 | 1993-07-19 | Bactericidal fabric, its producing method and use thereof |
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| Country | Link |
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| CN (1) | CN1031174C (en) |
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| CN1056075C (en) * | 1996-06-11 | 2000-09-06 | 谢志庆 | Chinese medicine paste |
| CN1086297C (en) * | 1999-10-11 | 2002-06-19 | 常毅坚 | A Chinese medicinal pill for treating gynecological diseases |
| CN101167894B (en) * | 2007-11-09 | 2011-02-16 | 北京中科雍和医药技术有限公司 | Traditional Chinese medicinal washing lotion for treating dermatitis, vulvitis and vaginitis |
| CN101637526B (en) * | 2008-07-28 | 2012-02-01 | 内蒙古医学院 | Drug for curing acne |
| CN102359013A (en) * | 2011-07-28 | 2012-02-22 | 吴江兰瑞特纺织品有限公司 | Natural antibacterial textile containing extract of sophora flavescens and preparation process thereof |
| CN102367634A (en) * | 2011-07-28 | 2012-03-07 | 吴江兰瑞特纺织品有限公司 | Coptis extract-containing natural antibacterial textile and preparation method thereof |
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