CN108096513A - A kind of drug for treating rotavirus enteritis and preparation method thereof - Google Patents
A kind of drug for treating rotavirus enteritis and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
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Abstract
The invention discloses a kind of drugs for treating rotavirus enteritis and preparation method thereof, it is mainly prepared according to a certain weight ratio by Rhizoma Atractylodis Macrocephalae, rhizoma atractylodis, hawthorn, evodia rutaecarpa, Chinese yam, cloves, malt, Radix Aucklandiae, the present invention have the function of tonifying spleen benefit stomach, eliminating dampness and in, warming spleen and stomach, removing internal cold, for quick, good effect for the treatment of rotavirus enteritis.
Description
Technical field
The present invention relates to a kind of drugs for treating rotavirus enteritis and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Rotavirus enteritis is the acute infectious disease of the digestive tract caused by rotavirus.Pathogen mainly by transmission,
Occur mainly in infant, often caused by A group rotavirus, onset peak in the fall, therefore named infantile diarrhea in Autumn.B group colyliforms
Virus can cause adult diarrhea.The traditional Chinese medical science then think rotavirus enteritis all hinder with taste, the dysfunction of the spleen in transport, dryness evil invasion and attack it is related.Due to west
Medicine treatment side effect is big, therefore people are to effectively treating the Chinese medicine of rotavirus enteritis there are great demand, up to now, also
The related report on the present invention is not found.
The content of the invention
The present inventor is on the basis of secret prescription handed down in the family from generation to generation, and the verification repeatedly Jing Guo clinical test, successfully works out finally
The effectively drug for the treatment of rotavirus enteritis, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine compositions of effective treatment rotavirus enteritis.
Another aim of the present invention is to provide the preparation methods of the Chinese medicine composition.
Drug of the present invention be selection Rhizoma Atractylodis Macrocephalae, rhizoma atractylodis, hawthorn, evodia rutaecarpa, Chinese yam, cloves, malt, Radix Aucklandiae, Chinese cassia tree, fructus amomi,
The membrane of a chicken's gizzard is combined preparation, each efficacy of drugs is caused to generate synergistic effect these pharmaceutical compositions, so as to effectively control
Treat rotavirus enteritis.It is because its sweet, warm bitter in taste wherein to select Rhizoma Atractylodis Macrocephalae, enters spleen, stomach, there is a tonifying spleen, beneficial stomach, eliminating dampness and in
Function, controls deficient QI of the spleen and stomach, do not feel like eating, and burnout lacks gas, empty swollen, diarrhea, phlegm and retained fluid, oedema, jaundice, arthritis with fixed pain caused by dampness, difficult urination, head
It is dizzy, spontaneous perspiration, nausea uneasiness.It is because its nature and flavor is worked hard to select rhizoma atractylodis, and temperature enters spleen, stomach, there is invigorating the spleen, eliminating dampness, Xie Yu is warded off dirty
Function, control wet soreness, burnout, gastral cavity ruffian abdominal distension is lost the appetite, vomiting, diarrhea, dysentery, malaria, phlegm and retained fluid, oedema, when
Gas is caught a cold, wind-cold-dampness arthralgia, atrophy, yctalopia.It is because its nature and flavor acid is sweet to select hawthorn, and tepor enters spleen, stomach, Liver Channel, has and help digestion
Product, scattered blood stasis, taenifugal function control meat Ji , Disorder lumps in the abdomen, phlegm and retained fluid, feeling of fullness, acid regurgitation, rush down dysentery, intestines wind, pain in the back, hernia, postpartum youngster
Pillow pain, lochiorrhagia, pediatric milk food stagnation.It is because its nature and flavor is worked hard to select evodia rutaecarpa, and temperature is toxic, enters liver, stomach, there is temperature
In, it relieves pain, qi-regulating, the function of eliminating dampness, controls inverse acid regurgitation of vomitting, jueyin headache, the cold syndrome in infant is vomited and diarrhoea, abdominal distention, tinea pedis, hernia, aphtha
Ulcer, dentalgia, eczema, impetigo.It is because its nature and flavor sweet and neutral to select Chinese yam, enters lung, spleen, kidney channel, there is an invigorating the spleen, tonifying lung, Gu
Kidney, the function of strengthening the essence control splenasthenic diarrhea, protracted dysentery, and cough due to consumptive disease is quenched one's thirst, under seminal emission, band, frequent urination.Select cloves be because
Its nature and flavor is acrid in flavour and warm in nature, enters stomach, spleen, kidney channel, there is middle benefit gas, warms up kidney, drops inverse function, control hiccup, vomits, gastric disorder causing nausea, rush down dysentery, Xin Fuleng
Bitterly, Xuan addictions, hernia, tinea.Select malt be because its nature and flavor it is sweet, tepor enters spleen, stomach, have help digestion and in, the work(of lower gas
Can, dyspepsia is controlled, swollen distention and fullness in the abdomen is lost the appetite, and vomiting and diarrhea, mammary swelling does not disappear.Selecting Radix Aucklandiae is worked hard because of its nature and flavor,
Temperature enters lung, liver, the spleen channel, there is promoting qi circulation and relieving pain, and the function of warming middle-JIAO for easing the stomach controls the syncope due to pathogenic cold stagnation of the circulation of vital energy, chest and abdomen swelling and pain, vomiting, diarrhea, diarrhea
It is tenesmus, cold hernia.It is because its property acrid-sweet flavor to select Chinese cassia tree, and heat enters kidney, spleen, bladder warp, there is complement sun, warming spleen and stomach, except product
Cold, the function of promoting blood circulation controls the Yang-function insufficiency of kidneyzang, cold weak pulse of limb, yang depletion collapse, abdominal pain diarrhea, cold hernia run quickly globefish, waist and knee crymodynia, Amenorrhea
Disorder lumps in the abdomen, cloudy subcutaneous ulcer, streamer and empty sun are floating more, heat in the upper and cold in the lower.It is because its nature and flavor is acrid in flavour and warm in nature to select fructus amomi, enters spleen, stomach, there is promoting the circulation of qi
In tune and stomach, the function be amusing, abdominal pain swollen ruffian is controlled, loss of appetite food stagnation, choke is cold to rush down cold dysentery, pregnant movement of the foetus every vomiting.It selects in chicken
Gold is because its nature and flavor sweet and neutral, enters spleen, stomach, controls stagnant, the function of strengthening the spleen and stomach, controls dyspepsia turgor, vomiting gastric disorder causing nausea, rush down dysentery,
Infantile malnutrition due to digestive disturbances or intestinalparasites is quenched one's thirst, and is lost and is drowned, larynx numbness acute tonsillitis, noma aphtha.
Specific embodiment
The drug dose of prescription of the present invention is also to be obtained by plenty of explorations of the inventor, and the dosage of each component is under
It states all to have in weight range and have a better effect：
0.5-1.5 grams of Rhizoma Atractylodis Macrocephalae, 3-5 grams of rhizoma atractylodis, 0.3-0.7 grams of hawthorn, 1-3 grams of evodia rutaecarpa, 0.5-1.5 grams of Chinese yam, cloves 1-2
Gram, 1-2 grams of malt, 1-2 grams of Radix Aucklandiae, 3-5 grams of Chinese cassia tree, 0.3-0.7 grams of fructus amomi, 0.5-1.5 grams of the membrane of a chicken's gizzard.
Preferably：
1 gram of Rhizoma Atractylodis Macrocephalae, 3 grams of rhizoma atractylodis, 0.5 gram of hawthorn, 2 grams of evodia rutaecarpa, 1 gram of Chinese yam, 1.5 grams of cloves, 1.5 grams of malt, Radix Aucklandiae 1.5
Gram, 3 grams of Chinese cassia tree, 0.5 gram of fructus amomi, 1 gram of the membrane of a chicken's gizzard.
The preparation method of drug of the present invention is as follows：
First, stock up
1st, Rhizoma Atractylodis Macrocephalae：First wheat bran is spread in hot pot, waits cigarette when emerging, by bighead atractylodes rhizome piece pour into it is micro- fry to faint yellow, take out, weed out bran
It is cooled after skin, per 100 jin of bighead atractylodes rhizome piece, with 10 day after tomorrow of wheat bran；
2nd, rhizoma atractylodis：Rhizoma atractylodis piece is taken, is sprayed and moistened with water in which rice has been washed, puts yellowish with being fried with slow fire in pot, taking-up, section is dry；
3rd, hawthorn：Net impurity is picked, weeds out core；
4th, evodia rutaecarpa：Crude drug is taken, carpopodium, branch and impurity is removed, weeds out chip；
5th, Chinese yam：First wheat bran is uniformly dispensed in hot pot, treating cigarette, add in yam slice and stir until faint yellow, take out, sieve
Wheat bran is removed, is cooled, per yam slice 100, with 10 jin of wheat bran；
6th, cloves：Decontamination, bennet are looked for, weeds out grey bits, the used time smashs to pieces；
7th, malt：Wheat tooth is taken to put micro- stir-fry in pot, and, to yellow, taking-up cools；
8th, Radix Aucklandiae：Banksia rose sheet is placed in iron wire plaque, with one layer of toilet paper, one layer of Radix Aucklandiae interval is tiled several layers, is put by stove fire or is dried
In dry chamber, it is dried to volatile oil contained in Radix Aucklandiae and infiltrates on paper, taking-up cools；
9th, Chinese cassia tree：Net impurity is picked, scrapes off tertia, tertia is smashed or scraped off to the used time, infiltrates a moment with warm water, section is dried；
10th, fructus amomi：Impurity and shell are picked, is smashed to pieces；
11st, the membrane of a chicken's gizzard：First sand is put into pot and is made popular, then the clean the membrane of a chicken's gizzard is put into pot, is stirred with slow boiling to pale brown
Color or coke yellow are heaved, and are taken out, are sifted out sand.
2nd, prepare
1st, Rhizoma Atractylodis Macrocephalae, rhizoma atractylodis, hawthorn, evodia rutaecarpa, Chinese yam, cloves, malt, Radix Aucklandiae, Chinese cassia tree, fructus amomi, the membrane of a chicken's gizzard after processing are ground
Wear into fine powder；
2nd, 10 grams of light-coloured vinegar is taken to mix with above-mentioned fine powder to be tuned into the big mouth vial of paste loading to obtain the final product.
Rhizoma Atractylodis Macrocephalae tonifying spleen benefit stomach in prescription, eliminating dampness and in, rhizoma atractylodis have invigorating the spleen, eliminating dampness, Xie Yu, ward off both dirty functions as monarch
Medicine；Hawthorn digesting product, scattered blood stasis, expelling tenia, evodia rutaecarpa have middle benefit gas, analgesic, qi-regulating, the function of eliminating dampness, are minister with Chinese yam, cloves
Medicine, Six-element medicine play jointly tonifying spleen benefit stomach, eliminating dampness and in, disperse accumulation food, the effect of warm in pain, treatment rotavirus enteritis effect it is complete
Face, and with tonifying spleen benefit stomach, eliminating dampness and in based on, can effect a permanent cure；Malt have help digestion and in, the function of lower gas is adjutant with Radix Aucklandiae；Meat
There is complement sun in osmanthus, and warming spleen and stomach, removing internal cold, the function of promoting blood circulation, to make medicine, is to take stopgap measures with remaining all medicines.
Drug of the present invention have the function of tonifying spleen benefit stomach, eliminating dampness and in, warming spleen and stomach, removing internal cold, for treating rotavirus enteritis
It is quick, good effect.
Carry out the advantageous effect of the present invention is further explained drug below by way of test example, these experiments include drug of the present invention
Animal toxicity test and clinical observation on the therapeutic effect experiment.
The animal toxicity test of [test example 1] drug of the present invention
West Germany rabbit 30, male and female dual-purpose are taken, rabbit abdomen hair removing is first exposed skin by weight 2.0-2.5kg, then will
The plaster mixed up is applied at rabbit abdomen baring skin, is then twined and tied up with gauze, daily coating 1 time, continuous coating 5 days, often
Its observation administration reaction, the results showed that rabbit activity, diet are normal, and drug is without bad toxic side effect.
The clinical observation on the therapeutic effect of [test example 2] drug of the present invention
1st, general information
Accept out-patient totally 34 for medical treatment.
2nd, diagnostic criteria
The symptom of rotavirus enteritis includes：Diarrhea arranges yellow watery stool, no mucus and purulence blood, and amount is more, and concomitant symptom has abdominal distension, abdomen
Ring, abdominal pain and Nausea and vomiting.
3rd, therapy
Select above-mentioned pasty medicament, patient given to use, spreads on Shenque acupuncture point, with adhesive plaster tight closure, daily dressing once, every time
6-9 grams, 1 course for the treatment of is used continuously in 7 days as one therapeutic course.
4th, efficacy assessment standard
It is effective：Rotavirus enteritis symptom disappears, and recovers normal, recovery from illness；
It improves：The phenomenon that patient's diarrhea, row's yellow watery stool, abdominal distension, borborygmus, abdominal pain and Nausea and vomiting, mitigates, rotavirus enteritis disease
Shape is clearly better, and progressively recovers normal；
It is invalid：Improvement standard person is not achieved.
5th, treatment results（It see the table below）：
In above-mentioned treatment, with drug therapy rotavirus enteritis patient 34 of the present invention, as a result effective 27, obvious effective rate is
79.41%, it improves 6, improvement rate 17.65%, invalid 1, total effective rate 97.06%.
Claims (3)
1. a kind of drug for treating rotavirus enteritis, it is characterised in that：It is made of the bulk pharmaceutical chemicals in following weight range：
0.5-1.5 grams of Rhizoma Atractylodis Macrocephalae, 3-5 grams of rhizoma atractylodis, 0.3-0.7 grams of hawthorn, 1-3 grams of evodia rutaecarpa, 0.5-1.5 grams of Chinese yam, cloves 1-2
Gram, 1-2 grams of malt, 1-2 grams of Radix Aucklandiae, 3-5 grams of Chinese cassia tree, 0.3-0.7 grams of fructus amomi, 0.5-1.5 grams of the membrane of a chicken's gizzard.
2. drug according to claim 1, wherein the dosage of each bulk pharmaceutical chemicals is：
1 gram of Rhizoma Atractylodis Macrocephalae, 3 grams of rhizoma atractylodis, 0.5 gram of hawthorn, 2 grams of evodia rutaecarpa, 1 gram of Chinese yam, 1.5 grams of cloves, 1.5 grams of malt, Radix Aucklandiae 1.5
Gram, 3 grams of Chinese cassia tree, 0.5 gram of fructus amomi, 1 gram of the membrane of a chicken's gizzard.
3. the preparation method of drug according to claim 1 or claim 2, it is characterised in that：It comprises the following steps：
（One）Stock
（1）Rhizoma Atractylodis Macrocephalae：First wheat bran is spread in hot pot, waits cigarette when emerging, by bighead atractylodes rhizome piece pour into it is micro- fry to faint yellow, take out, weed out
It is cooled after wheat bran, per 100 jin of bighead atractylodes rhizome piece, with 10 day after tomorrow of wheat bran；
（2）Rhizoma atractylodis：Rhizoma atractylodis piece is taken, is sprayed and moistened with water in which rice has been washed, puts yellowish with being fried with slow fire in pot, taking-up, section is dry；
（3）Hawthorn：Net impurity is picked, weeds out core；
（4）Evodia rutaecarpa：Crude drug is taken, carpopodium, branch and impurity is removed, weeds out chip；
（5）Chinese yam：First wheat bran is uniformly dispensed in hot pot, treating cigarette, adds in yam slice and stir until faint yellow, take out,
Wheat bran is weeded out, is cooled, per yam slice 100, with 10 jin of wheat bran；
（6）Cloves：Decontamination, bennet are looked for, weeds out grey bits, the used time smashs to pieces；
（7）Malt：Wheat tooth is taken to put micro- stir-fry in pot, and, to yellow, taking-up cools；
（8）Radix Aucklandiae：Banksia rose sheet is placed in iron wire plaque, with one layer of toilet paper, one layer of Radix Aucklandiae interval is tiled several layers, put by stove fire or
In drying chamber, it is dried to volatile oil contained in Radix Aucklandiae and infiltrates on paper, taking-up cools；
（9）Chinese cassia tree：Net impurity is picked, scrapes off tertia, tertia is smashed or scraped off to the used time, infiltrates a moment with warm water, section is dried；
（10）Fructus amomi：Impurity and shell are picked, is smashed to pieces；
（11）The membrane of a chicken's gizzard：First sand is put into pot and is made popular, then the clean the membrane of a chicken's gizzard is put into pot, is stirred with slow boiling to pale brown
Color or coke yellow are heaved, and are taken out, are sifted out sand；
（Two）It prepares
1st, Rhizoma Atractylodis Macrocephalae, rhizoma atractylodis, hawthorn, evodia rutaecarpa, Chinese yam, cloves, malt, Radix Aucklandiae, Chinese cassia tree, fructus amomi, the membrane of a chicken's gizzard after processing are ground
Wear into fine powder；
2nd, 10 grams of light-coloured vinegar is taken to mix with above-mentioned fine powder to be tuned into the big mouth vial of paste loading to obtain the final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711379145.7A CN108096513A (en) | 2017-12-20 | 2017-12-20 | A kind of drug for treating rotavirus enteritis and preparation method thereof |
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| CN201711379145.7A CN108096513A (en) | 2017-12-20 | 2017-12-20 | A kind of drug for treating rotavirus enteritis and preparation method thereof |
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Cited By (1)
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| CN109771602A (en) * | 2019-03-07 | 2019-05-21 | 张春梅 | For treating external application type Traditional Chinese medicine composition patch, preparation and its application of diarrhea |
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