CN108096497A - 一种用于治疗痛风的丸剂药物及其制备方法 - Google Patents

一种用于治疗痛风的丸剂药物及其制备方法 Download PDF

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CN108096497A
CN108096497A CN201810056153.6A CN201810056153A CN108096497A CN 108096497 A CN108096497 A CN 108096497A CN 201810056153 A CN201810056153 A CN 201810056153A CN 108096497 A CN108096497 A CN 108096497A
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孙素蓉
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Abstract

本发明属于中药制剂领域，目的是根据中医治疗痛风的认识机理而提供一种用于治疗痛风的丸剂药物，所述药物的各个组分及其质量份比如下：大黄30～150g、羌活100～280g、薏苡仁150～550g、金钱草150～650g、附子30～160g、车前草90～350g、杏仁80～150g、半夏30～100g、半枝莲120～250g、三七30～100g、大血藤90～160g、枣仁90～160g、虎杖90～160g、大蒜90～160g、女贞子60～160g、甘草30～150g、泽泻100～260g；本发明提供的药物是一个很好的中药组方。

Description

一种用于治疗痛风的丸剂药物及其制备方法
技术领域
本发明属于中药制剂领域，具体涉及其一种用于治疗痛风的丸剂药物，特别是供痛风患者使用的丸剂药物及其制备方法的领域。
背景技术
据相关资料显示：痛风是由单钠尿酸盐（MSU）沉积所致的晶体相关性关节病，与嘌呤代谢紊乱和（或）尿酸排泄减少所致的高尿酸血症直接相关，特指急性特征性关节炎和慢性痛风石疾病，主要包括急性发作性关节炎、痛风石形成、痛风石性慢性关节炎、尿酸盐肾病和尿酸性尿路结石，重者可出现关节残疾和肾功能不全。痛风常伴腹型肥胖、高脂血症、高血压、2型糖尿病及其心血管病等表现。
那么，就如何找到一种可有效治疗痛风的中药组合物，是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗痛风上，人们逐渐意识到了中医治疗痛风的优点，且在治疗过程中疗效好、见效快、毒副作用小等优势，针对现有西医治疗痛风的现状，本发明的目的是在于提供一种用于治疗痛风的丸剂药物，以解决痛风患者早日恢复健康的问题。该药物是以常见的中药为原料，通过选择合理的药物及其质量份比，可有效治疗上述痛风一证。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种用于治疗痛风的丸剂药物及其制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
大黄30～150g、羌活100～280g、薏苡仁150～550g、金钱草150～650g、附子30～160g、车前草90～350g、杏仁80～150g、半夏30～100g、半枝莲120～250g、三七30～100g、大血藤90～160g、枣仁90～160g、虎杖90～160g、大蒜90～160g、女贞子60～160g、甘草30～150g、泽泻100～260g，辅料：淀粉适量。
一种用于治疗痛风的丸剂药物及其制备方法，所述药物的各个组分及其质量份比如下所示：
大黄35～130g、羌活115～250g、薏苡仁180～480g、金钱草180～560g、附子38～140g、车前草100～310g、杏仁90～130g、半夏38～90g、半枝莲135～220g、三七38～90g、大血藤100～140g、枣仁100～140g、虎杖100～140g、大蒜100～140g、女贞子70～140g、甘草38～130g、泽泻115～220g，辅料：淀粉适量。
一种用于治疗痛风的丸剂药物及其制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
大黄115g、羌活220g、薏苡仁420g、金钱草480g、附子120g、车前草260g、杏仁116g、半夏80g、半枝莲200g、三七80g、大血藤120g、枣仁120g、虎杖120g、大蒜120g、女贞子120g、甘草118g、泽泻200g，辅料：淀粉适量。
一种用于治疗痛风的丸剂药物及其制备方法，其特征在于，所述方法包括如下步骤制备而成：
A、除淀粉外，将上述原料中药拣去杂质、粉尘及其干燥后，按照质量份比共研为极细末待用；
B、按照传统制备中药水丸剂的方法，将研磨好的极细末药物和淀粉过筛后，放入药器中混合拌均，然后制备成水丸剂（其水丸的粒度为：3.8mm～4.0mm），进而烘干，分装密封即得。
一种用于治疗痛风的丸剂药物及其制备方法，其特征在于，所述服用方法为：将制备好的水丸剂药物以每日三次服用，早中晚各服一次，给药量6g /次，温开水送服。30天为一个疗程，治疗2～4个疗程后，检查：血尿酸降至正常范围。
本发明组方中的各原料中药在中国药典、中国辞典以及其中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
大黄，性味：苦、性寒，具有攻积滞、清湿热、泻火、凉血、祛瘀、解毒之功效，用于治疗实热便秘、热结胸痞、湿热 泻痢、黄疸、淋病、水肿腹满、小便不利、目赤、咽喉肿痛、口舌生疮、胃热呕吐、吐血、咯血、衄血、便血、尿血、蓄血、经闭、产后瘀滞腹痛、癥瘕积聚、跌打损伤、热毒痈疡、丹毒、烫伤等症；
羌活，性味：辛苦、温，具有散表寒、祛风湿、利关节之功效，用于治疗感冒风寒、头痛无汗、风寒湿痹、项强筋急、骨节酸疼、风水浮肿、痈疽疮毒；
薏苡仁，性味：甘、淡、微寒，具有利湿健脾、舒筋除痹、清热排脓之功效，用于治疗水肿、脚气、小便淋沥、湿温病、泄泻带下、风湿痹痛、筋脉拘挛、肺痈、肠痈、扁平疣等症；
金钱草，性味：味甘、咸、性微寒，具有利湿退黄、利尿通淋、解毒消肿之功效，用于治疗湿热黄疸、胆胀胁痛、石淋、热淋、小便涩痛、痈肿疔疮、蛇虫咬伤；
附子，性味：味辛、甘、性大热，具有回阳救逆、补火助阳、散寒止痛之功效，用于治疗亡阳虚脱、肢冷脉微、心阳不足、胸痹心痛、虚寒吐泻、脘腹冷痛、肾阳虚衰、阳痿宫冷、阴寒水肿、阳虚外感、寒湿痹痛；
车前草，性味：味甘、性寒，具有清热、利尿、祛痰、凉血、解毒之功效，用于治疗水肿尿少、热淋涩痛、暑湿泻痢、痰热咳嗽、吐血衄血、痈肿疮毒；
杏仁，性味：苦、性微温，有小毒，具有祛痰止咳、平喘、润肠之功效，用于治疗外感咳嗽、喘满、喉痹、肠燥便秘；
半夏，性味：味辛、性温，具有燥湿化痰、降逆止呕、消痞散结之功效，用于治疗湿痰寒痰、咳喘痰多、痰饮眩悸、风痰眩晕、痰厥头痛、呕吐反胃、胸脘痞闷、梅核气，外治痈肿痰核；
半枝莲，性味：味辛、苦、性寒，具有清热、解毒、散瘀，止血、利尿消肿、定痛之功效，用于治疗吐血、衄血、血淋、赤痢、黄疸、咽喉疼痛、肺痈、疔疮、瘰疬、疮毒、癌肿、跌打刀伤、蛇咬伤；
三七，性味：甘、苦、微温，具有止血、散瘀、定通、消肿之功效，用于治疗刀伤、枪伤及其跌扑创伤出血不止，又可治吐血、衄血、便血、尿血、血痢、血崩、经水不止、产后恶血不下、血晕、血痛、目赤通肿、兽咬蛇伤；
大血藤，性味：味苦，性平，具有清热解毒、活血、祛风止痛之功效，用于治疗肠痈腹痛、热毒疮疡、经闭、痛经、跌扑肿痛、风湿痹痛等症；
枣仁，性味：甘、酸、平，具有补肝、宁心、敛汗、生津之功效，用于治疗虚烦不眠、惊悸多梦、体虚多汗、津伤口渴；
虎杖，性味：味微苦、性微寒，具有利湿退黄、清热解毒、散瘀止痛、止咳化痰之功效，用于治疗湿热黄疸、淋浊、带下、风湿痹痛、痈肿疮毒、水火烫伤、经闭、症瘕、趺打损伤、肺热咳嗽；
大蒜，性味：味辛、性温，具有解毒消肿、杀虫、止痢之功效，用于治疗痈肿疮疡、疥癣、肺痨、顿咳、泄泻、痢疾等症；
女贞子，性味：甘、苦、性凉，具有补益肝肾、清虚热、明目之功效，用于治疗头昏目眩、腰膝酸软、遗精、耳鸣、须发早白、骨蒸潮热、目暗不明；
甘草，性味：甘、平，具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效，用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒及其药物、食物中毒；
泽泻，性味：味甘、淡、性寒，具有利水渗湿、泄热通淋之功效，用于治疗小便不利、热淋涩痛、水肿胀满、泄泻、痰饮眩晕、遗精等症；
本发明药物是基于中医治疗痛风的原则，从依据痛风的病理机制及其药理作用认为：就痛风，本发明所提供的药物中的各原料中药药效共奏，对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述痛风的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个很好的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述：
实施例1：
一种用于治疗痛风的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
大黄115g、羌活220g、薏苡仁420g、金钱草480g、附子120g、车前草260g、杏仁116g、半夏80g、半枝莲200g、三七80g、大血藤120g、枣仁120g、虎杖120g、大蒜120g、女贞子120g、甘草118g、泽泻200g，辅料：淀粉适量。
实施例2：
一种用于治疗痛风的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
大黄130g、羌活250g、薏苡仁480g、金钱草560g、附子140g、车前草310g、杏仁130g、半夏90g、半枝莲220g、三七90g、大血藤140g、枣仁140g、虎杖140g、大蒜140g、女贞子140g、甘草130g、泽泻220g，辅料：淀粉适量。
实施例3：
一种用于治疗痛风的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
大黄150g、羌活280g、薏苡仁550g、金钱草650g、附子160g、车前草350g、杏仁150g、半夏100g、半枝莲250g、三七100g、大血藤160g、枣仁160g、虎杖160g、大蒜160g、女贞子160g、甘草150g、泽泻260g，辅料：淀粉适量。
典型病例：
经临床诊断治疗痛风患者共1300例，年龄为67岁以上的775例，只有525例为67岁以下。1300例患者中血尿酸降至正常范围的有910例，有效的260例，无效的130例。总有效率达90%。

Claims (3)

1.一种用于治疗痛风的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
大黄30～150g、羌活100～280g、薏苡仁150～550g、金钱草150～650g、附子30～160g、车前草90～350g、杏仁80～150g、半夏30～100g、半枝莲120～250g、三七30～100g、大血藤90～160g、枣仁90～160g、虎杖90～160g、大蒜90～160g、女贞子60～160g、甘草30～150g、泽泻100～260g，辅料：淀粉适量。
2.根据权利要求1所述的用于治疗痛风的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
大黄35～130g、羌活115～250g、薏苡仁180～480g、金钱草180～560g、附子38～140g、车前草100～310g、杏仁90～130g、半夏38～90g、半枝莲135～220g、三七38～90g、大血藤100～140g、枣仁100～140g、虎杖100～140g、大蒜100～140g、女贞子70～140g、甘草38～130g、泽泻115～220g，辅料：淀粉适量。
3.根据权利要求1至2所述的用于治疗痛风的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
大黄115g、羌活220g、薏苡仁420g、金钱草480g、附子120g、车前草260g、杏仁116g、半夏80g、半枝莲200g、三七80g、大血藤120g、枣仁120g、虎杖120g、大蒜120g、女贞子120g、甘草118g、泽泻200g，辅料：淀粉适量。
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* Cited by examiner, † Cited by third party
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