CN107714894A - 一种治疗痛风的丸剂药物及其制备方法 - Google Patents

一种治疗痛风的丸剂药物及其制备方法 Download PDF

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CN107714894A
CN107714894A CN201711119039.5A CN201711119039A CN107714894A CN 107714894 A CN107714894 A CN 107714894A CN 201711119039 A CN201711119039 A CN 201711119039A CN 107714894 A CN107714894 A CN 107714894A
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夏瑜
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Sichuan Jintang Haina Biomedical Technology Institute
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Abstract

本发明属于中药制剂领域，目的是根据中医治疗痛风的认识机理而提供一种治疗痛风的丸剂药物，所述药物的各个组分及其质量份比如下：土茯苓250～500g、生地100～160g、枸杞60～150g、山药150～350g、当归60～160g、白术80～160g、苍术30～100g、栀子60～120g、白芍60～160g、羌活30～120g、茵陈60～160g、黄芪100～350g、葛根100～160g、丹参50～160g、金钱草150～650g、牛膝50～160g、泽泻60～150g、地骨皮60～150g、甘草30～150g、赤芍60～150g；本发明提供的药物是一个很好的中药组方。

Description

一种治疗痛风的丸剂药物及其制备方法
技术领域
本发明属于中药制剂领域，具体涉及一种治疗痛风的丸剂药物，特别是供痛风患者使用的丸剂药物及其制备方法的领域。
背景技术
据文献资料显示：痛风是由单钠尿酸盐（MSU）沉积所致的晶体相关性关节病，与嘌呤代谢紊乱和（或）尿酸排泄减少所致的高尿酸血症直接相关，特指急性特征性关节炎和慢性痛风石疾病，主要包括急性发作性关节炎、痛风石形成、痛风石性慢性关节炎、尿酸盐肾病和尿酸性尿路结石，重者可出现关节残疾和肾功能不全。痛风常伴腹型肥胖、高脂血症、高血压、2型糖尿病及心血管病等表现。
那么，就如何找到一种可有效治疗痛风的中药组合物，是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗痛风上，人们逐渐意识到了中医治疗痛风的优点，且在治疗过程中疗效好、见效快、毒副作用小等优势，针对现有西医治疗痛风的现状，本发明的目的是在于提供一种治疗痛风的丸剂药物，以解决痛风患者早日恢复健康的问题。该药物是以常见的中药为原料，通过选择合理的药物及质量份比，可有效治疗上述痛风病。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种治疗痛风的丸剂药物及其制备方法，其特征在于，所述药物的各个组分及质量份比如下所示：
土茯苓250～500g、生地100～160g、枸杞60～150g、山药150～350g、当归60～160g、白术80～160g、苍术30～100g、栀子60～120g、白芍60～160g、羌活30～120g、茵陈60～160g、黄芪100～350g、葛根100～160g、丹参50～160g、金钱草150～650g、牛膝50～160g、泽泻60～150g、地骨皮60～150g、甘草30～150g、赤芍60～150g，辅料：淀粉适量。
一种治疗痛风的丸剂药物及其制备方法，其特征在于，所述药物的各个组分及质量份比如下所示：
土茯苓280～420g、生地115～140g、枸杞70～130g、山药180～310g、当归70～140g、白术90～140g、苍术38～90g、栀子70～105g、白芍70～140g、羌活38～105g、茵陈70～140g、黄芪115～310g、葛根115～140g、丹参58～140g、金钱草180～560g、牛膝58～140g、泽泻70～130g、地骨皮70～130g、甘草38～130g、赤芍70～130g，辅料：淀粉适量。
一种治疗痛风的丸剂药物及其制备方法，其特征在于，所述药物的各个组分及质量份比如下所示：
土茯苓360g、生地120g、枸杞118g、山药260g、当归120g、白术120g、苍术80g、栀子95g、白芍120g、羌活95g、茵陈120g、黄芪260g、葛根120g、丹参120g、金钱草480g、牛膝120g、泽泻118g、地骨皮118g、甘草118g、赤芍118g，辅料：淀粉适量。
一种治疗痛风的丸剂药物及其制备方法，其特征在于，所述方法包括如下步骤制备而成：
A、除淀粉外，将上述原料中药拣去杂质、粉尘及干燥后，按照质量份比共研为极细末待用；
B、按照传统制备中药水丸剂的方法，将研磨好的极细末药物和淀粉过筛后，放入药器中混合拌均，然后制备成水丸剂（其水丸的粒度为：3.8mm～4.0mm），进而烘干，消毒，分装密封即得。
一种治疗痛风的丸剂药物及其制备方法，其特征在于，所述服用方法为：将制备好的水丸剂药物以每日三次服用，早中晚各服一次，给药量5g /次，温开水送服。15天为一个疗程，服药2～5个疗程，症状明显减轻，血尿酸降至正常范围。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
土茯苓，性味：甘淡、平，具有解毒、除湿、利关节之功效，用于治疗梅毒、淋浊、筋骨挛痛、脚气、疔疮、痈肿、瘰疬等症；
生地，性味：甘、寒，具有清热凉血、养阴、生津之功效，用于治疗热病舌绛烦渴、阴虚内热、骨蒸劳热、内热消渴、吐血、衄血、发斑发疹；
枸杞，性味：甘、平，具有滋补肝肾、益精明目之功效，用于治疗虚劳精亏、腰膝酸痛、眩晕耳鸣、内热消渴、血虚萎黄、目昏不明等症；
山药，性味：甘、平，具有补脾、养肺、固肾、益精之功效，用于治疗脾虚泄泻、食少浮肿、肺虚咳喘、消渴、遗精、带下、肾虚尿频、外用治痈肿、瘰疬等症；
当归，性味：味甘、辛、苦、性温，具有补血、活血、调经止痛、润燥滑肠之功效，用于治疗血虚诸证、月经不调、经闭、痛经、癥瘕结聚、崩漏、虚寒腹痛、痿痹、肌肤麻木、肠燥便难、赤痢后重、痈疽疮疡、跌扑损伤；
白术，性味：味苦、甘、性温，具有健脾益气、燥湿利水、止汗、安胎之功效，用于治疗脾气虚弱、神疲乏力、食少少腹胀、大便溏薄、水饮内停、小便不利、水肿、痰饮眩晕、温痹酸痛、气虚自汗、胎动不安等症；
苍术，性味：辛、苦、温，具有燥湿健脾、去风湿之功效，用于治疗脾为湿困引起的运化失调、食欲不振、呕恶烦闷、腹胀泄泻、关节肢体疼痛；
栀子，性味：苦、寒，具有泻火除烦、清热利湿、凉血解毒、外用消肿止痛之功效，用于治疗热病心烦、湿热黄疸、淋证涩痛、血热吐衄、目赤肿痛、火毒疮疡、外治扭挫伤痛；
白芍，性味：苦、酸、微寒，具有平肝止痛、养血调经、敛阴止汗之功效，用于治疗头痛眩晕、胁痛、腹痛、四肢挛痛、血虚萎黄、月经不调、自汗、盗汗等症；
羌活，味辛、苦、性温，具有解表散寒、祛风胜湿、止痛之功效，用于治疗风寒感冒、风寒湿痹、项强筋急、骨节酸疼、风水浮肿、痈疽疮毒等症；
茵陈，性味：味苦、辛、性微寒，具有清利湿热、利胆退黄之功效，用于治疗黄疸尿少、湿温暑湿、湿疮瘙痒；
黄芪，性味：甘、微温，具有益卫固表、补气升阳、托毒生肌、利水消肿之功效，用于治疗气虚乏力、食少便溏、中气下陷、久泻脱肛、自汁盗汗、血虚萎黄、阴疽漫肿、气虚水肿、内热消渴；
葛根，味甘、辛、性凉，具有解肌退热、透疹、生津止渴、升阳止泻之功效，用于治疗表证发热、项背强痛、麻疹不透、热病口渴、阴虚消渴、热泻热痢、脾虚泄泻；
丹参，性味：苦、微寒，具有活血祛瘀、凉血消痈、养血安神之功效，用于治疗月经不调、心腹疼痛、癥瘕积聚、风湿热痹、疮疡肿痛、烦躁不寐、心悸、失眠等症；
金钱草，性味：味甘、咸、性微寒，具有利湿退黄、利尿通淋、解毒消肿之功效，用于治疗湿热黄疸、胆胀胁痛、石淋、热淋、小便涩痛、痈肿疔疮、蛇虫咬伤；
牛膝，性味：苦、酸、性平，具有补肝肾、强筋骨、活血通经、引敌国(火)下行、利尿通淋之功效，用于治疗腰膝酸痛、下肢痿软、血滞经闭、痛经、产后血瘀腹痛、徵瘕、胞衣不下、热淋、血淋、跌打损伤、痈肿恶疮、咽喉肿痛；
泽泻，性味：味甘、淡、性寒，具有利水渗湿、泄热通淋之功效，用于治疗小便不利、热淋涩痛、水肿胀满、泄泻、痰饮眩晕、遗精等症；
地骨皮，性味：甘、寒，具有清热凉血、退骨蒸潮热之功效，用于治疗骨蒸劳热、肺热咳嗽、血热出血症；
甘草，性味：甘、平，具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效，用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒及药物、食物中毒；
赤芍，性味：味苦、性微寒，具有清热凉血、散瘀止痛之功效，用于治疗热人营血、温毒发斑、吐血衄血、目赤肿痛、肝郁胁痛、经闭痛经、瘾瘕腹痛、跌扑损伤、痈肿疮疡；炒赤芍：炒后药性偏于缓和、活血止痛而不伤中，可用于瘀滞疼痛；酒赤芍：以活血散瘀力胜、清热凉血作用较弱，多用于闭经或痛经、跌打损伤。
本发明药物是基于中医治疗痛风的原则，从依据痛风的病理机制及药理作用认为：就痛风，本发明所提供的药物中的各原料中药药效共奏，对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述痛风的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个很好的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述：
实施例1：
一种治疗痛风的丸剂药物，其特征在于，所述药物的各个组分及质量份比如下所示：
土茯苓360g、生地120g、枸杞118g、山药260g、当归120g、白术120g、苍术80g、栀子95g、白芍120g、羌活95g、茵陈120g、黄芪260g、葛根120g、丹参120g、金钱草480g、牛膝120g、泽泻118g、地骨皮118g、甘草118g、赤芍118g，辅料：淀粉适量。
实施例2：
一种治疗痛风的丸剂药物，其特征在于，所述药物的各个组分及质量份比如下所示：
土茯苓420g、生地140g、枸杞130g、山药310g、当归140g、白术140g、苍术90g、栀子105g、白芍140g、羌活105g、茵陈140g、黄芪310g、葛根140g、丹参140g、金钱草560g、牛膝140g、泽泻130g、地骨皮130g、甘草130g、赤芍130g，辅料：淀粉适量。
实施例3：
一种治疗痛风的丸剂药物，其特征在于，所述药物的各个组分及质量份比如下所示：
土茯苓500g、生地160g、枸杞150g、山药350g、当归160g、白术160g、苍术100g、栀子120g、白芍160g、羌活120g、茵陈160g、黄芪350g、葛根160g、丹参160g、金钱草650g、牛膝160g、泽泻150g、地骨皮150g、甘草150g、赤芍150g，辅料：淀粉适量。
典型病例：
经临床诊断治疗痛风患者共1175例，年龄为62岁以上的770例，只有405例为62岁以下。1175例患者中血尿酸降至正常范围的有875例，有效的194例，无效的106例。总有效率达91%。

Claims (3)

1.一种治疗痛风的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
土茯苓250～500g、生地100～160g、枸杞60～150g、山药150～350g、当归60～160g、白术80～160g、苍术30～100g、栀子60～120g、白芍60～160g、羌活30～120g、茵陈60～160g、黄芪100～350g、葛根100～160g、丹参50～160g、金钱草150～650g、牛膝50～160g、泽泻60～150g、地骨皮60～150g、甘草30～150g、赤芍60～150g，辅料：淀粉适量。
2.根据权利要求1所述的治疗痛风的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
土茯苓280～420g、生地115～140g、枸杞70～130g、山药180～310g、当归70～140g、白术90～140g、苍术38～90g、栀子70～105g、白芍70～140g、羌活38～105g、茵陈70～140g、黄芪115～310g、葛根115～140g、丹参58～140g、金钱草180～560g、牛膝58～140g、泽泻70～130g、地骨皮70～130g、甘草38～130g、赤芍70～130g，辅料：淀粉适量。
3.根据权利要求1至2所述的治疗痛风的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
土茯苓360g、生地120g、枸杞118g、山药260g、当归120g、白术120g、苍术80g、栀子95g、白芍120g、羌活95g、茵陈120g、黄芪260g、葛根120g、丹参120g、金钱草480g、牛膝120g、泽泻118g、地骨皮118g、甘草118g、赤芍118g，辅料：淀粉适量。
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