CN108095067A - 一种缓解视疲劳及增强记忆力胶囊的制备方法 - Google Patents
一种缓解视疲劳及增强记忆力胶囊的制备方法 Download PDFInfo
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- Medicinal Preparation (AREA)
Abstract
本发明公开了一种缓解视疲劳及增强记忆力胶囊的配方，涉及医药保健食品技术领域，含以下组份：DHA藻油微囊粉250‑450重量份、叶黄素粉5‑10重量份、葡萄糖酸锌8‑15重量份、牛磺酸40‑80重量份、桑葚提取物20‑40重量份、淀粉50‑100重量份、硬脂酸镁5‑8重量份。另外，本发明还公开了该缓解视疲劳及增强记忆力胶囊的制备方法。本发明提供的缓解视疲劳及增强记忆力胶囊对易视觉疲劳者、记忆力低下者有明显效果，并且全程同线处理，避免了不稳定因素造成的营养流失，整个制备工艺在一定的洁净区内完成，保证了工作环境的洁净，最大程度的降低环境对胶囊的影响。
Description
技术领域
本发明涉及医药保健食品技术领域，具体涉及一种缓解视疲劳及增强记忆力胶囊的制备方法。
背景技术
视疲劳是目前眼科常见的一种疾病，患者的症状多种多样，常见的有近距离工作不能持久，出现眼及眼眶周围疼痛、视物模糊、眼睛干涩、流泪等，严重者头痛恶心眩晕它不是独立的疾病，而是由于各种原因引起的一组疲劳综合征其发生原因也是多种多样的。
随着生活节奏越来越快，人们所承受压力也越来越大，适度的压力可以促进记忆力，但压力过大会伤害记忆力。研究表明，压力使得肾上腺分泌皮质醇，而皮质醇过高则可以杀死大脑中对学习和记忆起到关键作用的海马。青年人往往把大量的精力投入到工作中，工作量过大会让人产生过重的心理压力，人也容易产生焦虑、抑郁等负面情绪，反而增加压力，影响记忆力。长此以往，必然陷入一个恶性循环中。现有技术多以越橘、蓝苟、叶黄素醋、维生素C等单方成分或结合银杏、其他维生素等全局抗氧化成分为主。目前市面上较少有一款携带方便，既可以缓解视觉疲劳又可以增强记忆力的胶囊物品。
中国专利申请号201610092634.3公开了一种能够有效缓解视觉疲劳的薄荷饮料，包括以下重量份组分：槐米、鲜观音柴叶、薄荷提取物、花色提取物、黄秋葵花提取物、干粉酪、胡萝卜原汁、蛋白磷酸肽、烟酰胺、甘氨酸、茶氨酸、维生素C、叶黄素、柠檬酸、酵母菌、黄原胶以及食用级草木灰浸泡液等。该发明的薄荷发酵饮料，利用观音柴的凝胶特性，加载一半酵母菌创造发酵环境中存在发酵体的内外双重发酵，内外双重发酵相互作用，丰富了发酵产物，营养丰富具有显著缓解视觉疲劳的效果。但是制作工艺较复杂，不利于工业化大生产。
中国专利申请号201510822251.2公开了一种缓解视疲劳的固体饮料，包含下列重量份数的组分：越橘提取物20-30份，DHA藻油微囊粉80-120份，针叶樱桃浓缩物40-60份和叶黄素醋微囊粉5一10份，该发明提供的固体饮料可以提供全面的视力保护作用和抗疲劳作用。但是功能单一，不具有增强记忆力的效果。
发明内容
本发明的目的在于提供一种缓解视疲劳及增强记忆力胶囊的制备方法，以解决现有技术中导致的上述缺陷。
本发明通过以下技术方案来实现，一种缓解视疲劳及增强记忆力胶囊的配方，按重量份计，包括：
优选的，一种缓解视疲劳及增强记忆力胶囊的配方，按重量份计，包括：
一种缓解视疲劳及增强记忆力胶囊的制备方法，包括如下步骤：
(1)取符合企业标准的相关要求经检验合格的DHA藻油微囊粉、叶黄素粉、葡萄糖酸锌、牛磺酸、桑葚提取物、淀粉、硬脂酸镁，将原辅料除去外包装，内包装通过缓冲间进入洁净区；
(2)粉碎、过筛：将葡萄糖酸锌、桑葚提取物粉碎，过筛得粒径38-45μm得细粉备用；
(3)称量：按配方比例称取DHA藻油微囊粉、叶黄素粉、葡萄糖酸锌、牛磺酸、桑葚提取物、淀粉、硬脂酸镁备用；
(4)一混：将称量好的DHA藻油微囊粉、叶黄素粉、葡萄糖酸锌、牛磺酸、桑葚提取物、淀粉用多向三维运动混合机混合30-45min；
(5)二混：将步骤(4)混合粉加入称量好的硬脂酸镁，混合5-10min，得总混合粉；
(6)灌装胶囊：将总混合粉用全自动硬胶囊充填机灌装胶囊，得胶囊，0.5g-0.8g/粒；
(7)抛光、挑选：除去胶囊表面的粉末；除去不合格的产品；
(8)包装、质检、入库。
优选的，所述步骤(1)中DHA藻油微囊粉是由二十二碳六烯酸油脂、辛烯基琥珀酸淀粉钠、L-抗坏血酸棕榈酸酯、抗坏血酸钠、柠檬酸、磷酸三钙、麦芽糊精以及白砂糖组成。
优选的，所述步骤(1)中叶黄素粉是由叶黄素、β–环糊精、麦芽糊精组成。
优选的，所述步骤(8)包装分为内包装和外包装。
优选的，所述内包装所用材料用符合YBB00262002口服固体药用聚酯瓶的包装材料装瓶；所述外包装用符合GB/T6543运输包装用单瓦楞纸箱和双瓦楞纸箱的纸箱包装。
采用以上技术方案，与现有技术相比，本发明具有以下优点：
1、二十二碳六烯酸，即DHA，是人体所必需的一种多不饱和脂肪酸，鱼油中含量较多。一种含有22个碳原子和6个双键的直链脂肪酸。只有其n-3家族的22:6Δ4c，7c，10c，13c，16c，19c异构体以天然形式大量存在于鱼油中(占脂肪酸总量的10％～15％)，动物的甘油磷脂则含有不等量的该酸。在代谢过程中，可从α亚麻酸生成。DHA是神经系统细胞生长及维持的一种主要元素，是大脑和视网膜的重要构成成分，在人体大脑皮层中含量高达20％，在眼睛视网膜中所占比例最大，约占50％，因此，对胎婴儿智力和视力发育至关重要；叶黄素是一种性能优异的抗氧化剂，可抵御氧自由基在人体内造成细胞与器官损伤，预防机体衰老引发的心血管硬化、冠心病等症状。最重要的是叶黄素是唯一可以存在眼睛水晶体的类胡萝卜素成分，是视网膜黄斑的主要色素和抗氧化成分，许多眼科疾病都与叶黄素的缺乏有很大关系，可见叶黄素对于眼睛起着重要保护作用；牛磺酸促进婴幼儿脑组织和智力发育。
2、综上所述，本发明对记忆力低下者、视力易疲劳者有显著效果。
具体实施方式
为使本发明的技术手段、创作特征、达成目的与功效易于明白了解，下面结合具体实施方式，进一步阐述本发明。
实施例1
一种缓解视疲劳及增强记忆力胶囊的配方，按重量份计：
实施例2
一种缓解视疲劳及增强记忆力胶囊的配方，按重量份计：
实施例3
一种缓解视疲劳及增强记忆力胶囊的配方，按重量份计：
实施例4
一种缓解视疲劳及增强记忆力胶囊的配方，按重量份计：
实施例5
一种缓解视疲劳及增强记忆力胶囊的配方，按重量份计：
值得注意的是，在实施例1-5中，上述所述的制作缓解视疲劳及增强记忆力胶囊的制备方法，包括以下步骤：
(1)取符合企业标准的相关要求经检验合格的DHA藻油微囊粉、叶黄素粉、葡萄糖酸锌、牛磺酸、桑葚提取物、淀粉、硬脂酸镁，将原辅料除去外包装，内包装通过缓冲间进入洁净区；
(2)粉碎、过筛：将葡萄糖酸锌、桑葚提取物粉碎，过筛得粒径38μm得细粉备用；
(3)称量：按配方比例称取DHA藻油微囊粉、叶黄素粉、葡萄糖酸锌、牛磺酸、桑葚提取物、淀粉、硬脂酸镁备用；
(4)一混：将称量好的DHA藻油微囊粉、叶黄素粉、葡萄糖酸锌、牛磺酸、桑葚提取物、淀粉用多向三维运动混合机混合30min；
(5)二混：将步骤(4)混合粉加入称量好的硬脂酸镁，混合5min，得总混合粉；
(6)灌装胶囊：将总混合粉用全自动硬胶囊充填机灌装胶囊，得胶囊，0.5g-0.8g/粒；
(7)抛光、挑选：除去胶囊表面的粉末；除去不合格的产品；
(8)包装、质检、入库。
此外，所述步骤(1)中DHA藻油微囊粉是由二十二碳六烯酸油脂、辛烯基琥珀酸淀粉钠、L-抗坏血酸棕榈酸酯、抗坏血酸钠、柠檬酸、磷酸三钙、麦芽糊精以及白砂糖组成。所述步骤(1)中叶黄素粉是由叶黄素、β–环糊精、麦芽糊精组成。所述步骤(8)包装分为内包装和外包装。所述内包装所用材料用符合YBB00262002口服固体药用聚酯瓶的包装材料装瓶；所述外包装用符合GB/T6543运输包装用单瓦楞纸箱和双瓦楞纸箱的纸箱包装。
小鼠急性毒性试验：
采用最大耐受剂量法，选用体重为18-22g的昆明种小鼠20只，雌雄各半。取本发明缓解视疲劳及增强记忆力胶囊内容物50g加1％的羧甲基纤维素钠至100mL。给小鼠一日内间隔4小时经口灌胃2次，每次灌胃体积为0.2mL/10g.bw，累积剂量为20.00g/kg.bw。首次灌胃前禁食16小时，灌胃后连续观察两周，记录中毒表现及死亡情况。实验结果如下：
| 性别 | 动物数(只) | 途径 | 剂量(g/kg.bw) | 死亡数(只) | MTD(g/kg.bw) |
| 雌 | 10 | 经口 | 20 | 0 | >20.00 |
| 雄 | 10 | 经口 | 20 | 0 | >20.00 |
以20.00g/kg.bw剂量的本发明样品的缓解视疲劳及增强记忆力胶囊内容物给两种性别的昆明种小鼠灌胃后未见明显中毒症状，观察14天五死亡。观察期末将受试动物处死进行解剖检查，肝、脾、肾、胃、肠、心、肺等主要脏器，未见明显异常改变。说明本发明缓解视疲劳及增强记忆力胶囊对昆明种小鼠雌雄小鼠最大耐受量大于20.00g/kg.bw，属于无毒级。
实验例、本发明所述制品用于易视觉疲劳者、记忆力低下者患者的的临床验证统计：
临床观察易视觉疲劳者病例60例，分成6组进行观察，前五组分别实施例1-5的制品，最后一组不服用任何药物胶囊。
主诉症状：视物稍久则模糊，有的甚至无法写作或阅读，眼睛干涩、头昏痛。
服用胶囊数及次数：每日两次，每次两粒，7天为一个疗程。
统计结果：50例临床患者服用本发明的胶囊，大部分患者获得了明显的治疗效果，主要表现为看东西时间比之前坚持时间延长，眼睛干涩、头昏痛症状基本消失，不再出现无法写作或阅读的现象，有效率98％，治愈率52％。
由实验结果可知，本发明对易视觉疲劳者有明显效果，能够缓解视觉疲劳。
临床观察易记忆力低下者病例60例，分成6组进行观察，前五组分别实施例1-5的制品，最后一组不服用任何药物胶囊。
主诉症状：记忆力减退、工作紧张、焦虑、易怒。
服用胶囊数及次数：每日两次，每次两粒，7天为一个疗程。
统计结果：50例临床患者服用本发明的胶囊，大部分患者获得了明显的治疗效果，主要表现为记忆力较之前有了明显的进步，而工作紧张、焦虑、易怒现象基本不再出现。有效率96％，治愈率50％。
由实验结果可知，本发明对记忆力低下者有明显效果，能够辅助改善记忆。
综上所述，本发明提供的缓解视疲劳及增强记忆力胶囊对易视觉疲劳者、记忆力低下者有明显效果，并且全程同线处理，避免了不稳定因素造成的营养流失，整个制备工艺在一定的洁净区内完成，保证了工作环境的洁净，最大程度的降低环境对胶囊的影响。
由技术常识可知，本发明可以通过其它的不脱离其精神实质或必要特征的实施方案来实现。因此，上述公开的实施方案，就各方面而言，都只是举例说明，并不是仅有的。所有在本发明范围内或在等同于本发明的范围内的改变均被本发明包含。
Claims (7)
1.一种缓解视疲劳及增强记忆力胶囊的配方，其特征在于，按重量份计，包括：
2.根据权利要求1所述的一种缓解视疲劳及增强记忆力胶囊的配方，其特征在于，按重量份计，包括：
3.根据权利要求1-2任一项所述的缓解视疲劳及增强记忆力胶囊的制备方法，其特征在于，包括如下步骤：
(1)取符合企业标准的相关要求经检验合格的DHA藻油微囊粉、叶黄素粉、葡萄糖酸锌、牛磺酸、桑葚提取物、淀粉、硬脂酸镁，将原辅料除去外包装，内包装通过缓冲间进入洁净区；
(2)粉碎、过筛：将葡萄糖酸锌、桑葚提取物粉碎，过筛得粒径38-45μm得细粉备用；
(3)称量：按配方比例称取DHA藻油微囊粉、叶黄素粉、葡萄糖酸锌、牛磺酸、桑葚提取物、淀粉、硬脂酸镁备用；
(4)一混：将称量好的DHA藻油微囊粉、叶黄素粉、葡萄糖酸锌、牛磺酸、桑葚提取物、淀粉用多向三维运动混合机混合30-45min；
(5)二混：将步骤(4)混合粉加入称量好的硬脂酸镁，混合5-10min，得总混合粉；
(6)灌装胶囊：将总混合粉用全自动硬胶囊充填机灌装胶囊，得胶囊，0.5g-0.8g/粒；
(7)抛光、挑选：除去胶囊表面的粉末；除去不合格的产品；
(8)包装、质检、入库。
4.根据权利要求3所述的一种缓解视疲劳及增强记忆力胶囊的制备方法，其特征在于：所述步骤(1)中DHA藻油微囊粉是由二十二碳六烯酸油脂、辛烯基琥珀酸淀粉钠、L-抗坏血酸棕榈酸酯、抗坏血酸钠、柠檬酸、磷酸三钙、麦芽糊精以及白砂糖组成。
5.根据权利要求3所述的一种缓解视疲劳及增强记忆力胶囊的制备方法，其特征在于：所述步骤(1)中叶黄素粉是由叶黄素、β–环糊精、麦芽糊精组成。
6.根据权利要求3所述的一种缓解视疲劳及增强记忆力胶囊的制备方法，其特征在于：所述步骤(8)包装分为内包装和外包装。
7.根据权利要求6所述的一种缓解视疲劳及增强记忆力胶囊的制备方法，其特征在于：所述内包装所用材料用符合YBB00262002口服固体药用聚酯瓶的包装材料装瓶；所述外包装用符合GB/T6543运输包装用单瓦楞纸箱和双瓦楞纸箱的纸箱包装。
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