CN108085125A - The low temperature of sea-buckthorn medicinal substrate oil produces production technology - Google Patents

The low temperature of sea-buckthorn medicinal substrate oil produces production technology Download PDF

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Publication number
CN108085125A
CN108085125A CN201611017898.9A CN201611017898A CN108085125A CN 108085125 A CN108085125 A CN 108085125A CN 201611017898 A CN201611017898 A CN 201611017898A CN 108085125 A CN108085125 A CN 108085125A
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solvent
sea
oil
low temperature
temperature
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石佳媛
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/02—Pretreatment
    • C11B1/04—Pretreatment of vegetable raw material
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/06—Production of fats or fatty oils from raw materials by pressing
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/001—Refining fats or fatty oils by a combination of two or more of the means hereafter
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/006—Refining fats or fatty oils by extraction
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/008—Refining fats or fatty oils by filtration, e.g. including ultra filtration, dialysis
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/12—Refining fats or fatty oils by distillation
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/16—Refining fats or fatty oils by mechanical means
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B5/00—Preserving by using additives, e.g. anti-oxidants

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mechanical Engineering (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a kind of low temperature of sea-buckthorn medicinal substrate oil to produce production technology, including：By ripe sea buckthorn fruit through cleaning, its Normal juice is taken after squeezing, its Normal juice is subjected to first time separation with seperator, the cold storage low-temperature precipitation of its crude oil is taken, then carries out second with seperator and separates, takes edible vegetable oil, low temperature net formula coarse filtration and the board-like refined filtration of low temperature, seabuckthorn essential oil is obtained, is then placed in vacuum concentration equipment, solvent A stirring, precipitation is first added in, removes unsaponifiable matter and saturation tartaric acid；It adds solvent B stirrings, precipitation, remove the dregs of fat；It is dehydrated under conditions of vacuum critical-temperature, room temperature is rapidly cooled to after clean, added in solvent C, examined after stirring, sea-buckthorn medicinal substrate oil is made in sterilizing, packaging.

Description

The low temperature of sea-buckthorn medicinal substrate oil produces production technology
Technical field
The present invention relates to a kind of production technologies of the medicinal matrix oil of plant, are especially a kind of the low of sea-buckthorn medicinal substrate oil Temperature produces production technology.
Background technology
Sea-buckthorn is a category kind of the most northern feature of Elaeangnaceae plant, it is littoral originating from the preceding Tethys of hundreds of millions of years Himalaya --- Hengduanshan Mountains In China region, NATURAL DISTRIBUTION in Eurasia paramos, frigid zone, Temperate Region in China one kind rich in oil plant Object, the oil content of ripening fruits may be up to 15- ¨ % or so.Since sea-buckthorn is obtained in very long competing of nature selects evolutionary process Taken the natural compatibility and self-polymerization of a series of group vitamins for having resistance free from worldly cares and bioactive substance, thus with pair Most of diseases that the mankind are currently known, particularly three big difficult and complicated illness (cardiovascular and cerebrovascular, diabetes, cancer) have special control Therapeutic effect.Seabuckthorn Oil preparation method traditional at present is divided into CP method (also known as diffusion method or displacement method), hot-working method, squeezes method With four kinds of extraction, above-mentioned preparation method is introduced in turn below：
CP method --- it is the mix preparation of a kind of sea-buckthorn and sunflower oil, such as country of the former Soviet Union uses this production method always, But due to as diffusion or replacing solvent using sunflower oil, therefore solvent naphtha can not be separated with Seabuckthorn Oil, highest purity only has 60%, purity is low also to necessarily affect curative effect.
Hot-working method --- it is that will be heated to 90 DEG C or more after related (a small amount of) branches and leaves of sea-buckthorn mellow fruit directly crush, and Hot water is continuously added, Seabuckthorn Oil is obtained using skimming mode, pick-up rate only has 55%-70%, since open hot-working is made Industry, therefore the loss of the biological activity of volatile materials is very big, only indivedual laboratories use at present, are yet there are no so far with this work The report of industry production method, and the obtained oil in laboratory is miscella.
Squeeze method --- edible oil is derived from, such as the processing method of rapeseed oil, based on Seabuckthorm Seed Oil, and by fructus hippophae Edible vegetable oil is mixed with, and to improve yield (i.e. pick-up rate, similarly hereinafter), but still is difficult to reach 50% and is obtained miscella, is i.e. sea-buckthorn Existing Marc oil in oil, and have seed oily, the two can not separate, and storage life is slightly long, will generate toxicant.Current only indivedual mountains Individual workship of area uses.
Extraction --- for Seabuckthorm Seed Oil, using petroleum ether etc. as solvent, although yield is higher, having higher has Solvent remains, and swallows when taking difficult, the side effect of gastric disorder causing nausea vomiting and allergic rash easily occurs.
The content of the invention
It is an object of the invention to develop a kind of low temperature of " sea-buckthorn medicinal substrate oil " to produce production technology, use is advanced Low temperature preparation method and solvent burden ratio make Seabuckthorn Oil obtain maximum yield, and its medicinal organism active material are made to obtain most It is protected on a large scale using with the quality time limit to greatest extent, realizes industrialized production, providing one kind for the mankind both can be direct Oral administration and externally, but also as compatibility medium carrier, for the new Seabuckthorn Oil system of various drugs, health products can be made after compound Product lay the basis for realizing industrialized production.
The technical solution of the present invention is as follows：
Ripe sea buckthorn fruit is taken into its Normal juice through cleaning, after squeezing, it is characterized in that：Its Normal juice is carried out for the first time with seperator Separation, takes the cold storage low-temperature precipitation of its crude oil, then carries out second of separation with seperator, takes edible vegetable oil, low temperature net formula coarse filtration and low The board-like refined filtration of temperature, obtains seabuckthorn essential oil, is then placed in vacuum concentration equipment, first adds in solvent A stirring, precipitation, removes not soap Compound and saturation tartaric acid；It adds solvent B stirrings, precipitation, remove the dregs of fat；It is dehydrated under the conditions of vacuum critical-temperature ground, Room temperature is rapidly cooled to after clean, solvent C is added in, is examined after stirring, sea-buckthorn medicinal substrate oil is made in sterilizing, packaging.
The technical solution of the present invention further includes：
Solvent A is de- soap solvent, is mixed by pure water and caustic soda weight ratio by 25: 1, and solvent B is depickling solvent, by softening Distilled water is mixed with sodium chloride by weight 20: 1, and solvent C is anti-peroxide solvent, by vitamin C and provitamin A by weight Amount 50: 1 mixed dissolution of percentage forms；The weight percent of entire dosage is seabuckthorn essential oil：95.485-97.49%, solvent A： 1.5-3%, solvent B：1-1.5%, solvent C：0.01-0.015%.
Parameter in above-mentioned technique is：" low temperature ", temperature：2℃-10℃；When " cold storage " is 4-6 small/time；" stirring " is 20 Minute/time；" vacuum " is -0.06Mpa pressure；" critical-temperature " is 60 DEG C -80 DEG C；" room temperature " temperature is 18 DEG C -25 DEG C.
In separation circuit twice, separation for the first time is separated using butterfly seperator, and second of separation is using rod-type Seperator is separated, and separation rotating speed is at 3000 to 5000 revs/min.
Advantages of the present invention and effect are as follows：
(1) indices of " medicinal substrate " can be achieved：A, component target：Total seabuckthorn flavone compound >=15mg/g, vitamin E >=1.0mg/g, total carotinoid >=1.5mg/g；
B, physical and chemical index：Refraction index (20 DEG C) 1.45-1.5, density (20 DEG C)：0.89-0.91, acid value：≤ 20, it moisture and waves Stimulating food：＜ 3%；
C, sanitary index：Arsenic≤0.1ppm, mercury≤0.05ppm, peroxide value≤0.4%.
(2) processing technology flow is perfect, and production technology reasonable, new technology is safe and reliable, manufactured goods stable quality, real Large-scale production technology is showed.
(3) due to the solvent burden ratio technology using (grade) twice separation, low temperature and reasonable science, therefore sea buckthorn fruit can be passed through Sea buckthorn juice Normal juice oil constituents extraction after squeezing goes out more than 98%.
(4) due to using low temperature process, therefore the medicinal natural work contained by its sea-buckthorn medicinal substrate oil is protected to greatest extent Property material composition, maintains the total flavonoid in Seabuckthorn Oil, total carotinoid, various liposoluble vitamin races and unsaturated lipid Fat acid, fatty alcohol, terpene, phenols, amino acid, phosphoric acid etc. have and promote cytoactive, curative effect wide spectrum synthesis, without any poison Side effect processes the features such as simple and practicable.
(5) liquid for oral administration directly used, external application oil can not only be produced by realizing, but also can be used as compatibility medium carrier, through multiple The a variety of sea-buckthorn oil products of capsule and pill, emulsion, paste, pulvis etc. made of side are protected as with anti-aging, anti-inflammatory, reinforced immunological The new health care product of health-care function and with to cardiovascular and cerebrovascular disease, diabetes, cancer, stomach trouble and the surgical operation edge of a knife and The five major class disease such as trauma care has the new drug of unique curative effect.
The embodiment of the present invention is as follows：
Ripe sea buckthorn fruit is collected, selected selected, airing takes its sea buckthorn fruit after cleaning to squeeze, by the original after squeezing Juice carries out first time separation with butterfly (or using other layering acquisition modes) seperator, takes its sea-buckthorn crude oil, (6 is small through cold storage When/time, can be used 1-2 times), (2 DEG C -10 DEG C) of low temperature precipitation, by net crude oil after cold storage precipitation the upper surface of with rod-type seperator (or Using other impurity elimination modes) carry out second and separate, take edible vegetable oil thereon, be poured into the low temperature net formula coarse filtration tank of up-down structure into Row first time coarse filtration, strainer are 120 mesh of ＞；There is board-like pressurization high density filter in coarse filtration device bottom oil outlet, still exist Second of (grade) coarse filtration is carried out under the conditions of low temperature (2 DEG C -10 DEG C), seabuckthorn essential oil is obtained, using this seabuckthorn essential oil as basis weight Proportioning, is put into vacuum concentration equipment (equipment of market sale), first adds in de- soap solvent A, by pure water and caustic soda by weight Amount mixed than 25: 1, stir 20 minutes/time, it is 1-2 time common, it is cold store precipitate 4-6 it is small when/time, it is 1-2 times common, removing (releasing) Unsaponifiable matter in seabuckthorn essential oil, saturation tartaric acid；Then depickling solvent B is added, the solvent is by softening distilled water and sodium chloride It mixes by weight 20: 1, stirs 20 minutes/time, it is 1-2 time common, when cold storage precipitation 4-6 is small/time, 1-2 times common, removing is oily Slag, filter screen are 150 mesh of ＞；Then it is dehydrated, does under vacuum -0.06Mpa pressure conditions of 65 DEG C -80 DEG C of critical-temperature Rapid water cooling adds in anti-peroxide solvent C, (i.e. β is recklessly by vitamin C and provitamin A for the solvent to 18 DEG C -25 DEG C of room temperature after net Radish element) mixed dissolution forms, and stirs 20 minutes/time, and it is 1-2 times common, it is tested, sterilized, packed using routine techniques, that is, made Into sea-buckthorn medicinal substrate oil.Above-mentioned weight percentages content is as follows：
Seabuckthorn essential oil：95.485-97.49%
Solvent A：1.5-3%
Solvent B：1-1.5%
Solvent C：0.01-0.015%
With sea-buckthorn medicinal substrate produced by the present invention oil, appearance is in brownish red, transparent no precipitation, no solid content.Finally need Bright is：Just there is the effect of abundant i.e. when " medicinal " refers to reach following three indexs in title of the present invention：Sea-buckthorn is yellow Ketone total content >=15mg/g (or Isorhamnetin content >=5mg/g)；Vitamin E >=1.0mg/g；Total carotinoid >=1.5mg/ g。
So-called " matrix " refer to simple substance as compatibility basic substance, simple substance is free from other non-protoplasm compositions and impurity Substance.

Claims (4)

1. the low temperature of sea-buckthorn medicinal substrate oil produces production technology, including：By ripe sea buckthorn fruit through cleaning, it is taken after squeezing Normal juice, it is characterized in that：Its Normal juice is subjected to first time separation with seperator, the cold storage low-temperature precipitation of its crude oil is taken, then uses seperator It carries out second to separate, takes edible vegetable oil, low temperature net formula coarse filtration and the board-like refined filtration of low temperature, obtain seabuckthorn essential oil, be then placed in vacuum In concentrator, first add in solvent A stirring, precipitation, remove unsaponifiable matter and saturation tartaric acid；Add solvent B stirring, precipitation, Remove the dregs of fat；It is dehydrated under conditions of vacuum critical-temperature, room temperature is rapidly cooled to after clean, solvent C is added in, after stirring It examines, sea-buckthorn medicinal substrate oil is made in sterilizing, packaging.
2. the low temperature of sea-buckthorn medicinal substrate oil according to claim 1 produces production technology, it is characterized in that：Solvent A is de- Soap solvent is mixed by pure water and caustic soda weight ratio by 20: 1, and solvent B is depickling solvent, by softening distilled water and chlorination Sodium is mixed by weight 20: 1, and solvent C is anti-peroxide solvent, by vitamin C and provitamin A by weight percentage 45: 1 Mixed dissolution forms；The weight percent of entire dosage is seabuckthorn essential oil：95.485-97.49%, solvent A：1.5-3%, solvent B：1-1.5%, solvent C：0.01-0.015%.
3. the low temperature of sea-buckthorn medicinal substrate oil according to claim 1 produces production technology, it is characterized in that：In above-mentioned technique Parameter be：" low temperature ", temperature：2℃-10℃；When " cold storage " is 4-6 small/time；" stirring " is 20 minutes/time；" vacuum " for- 0.06Mpa pressure；" critical-temperature " is 60 DEG C -80 DEG C；" room temperature " temperature is 18 DEG C -25 DEG C.
4. the low temperature of sea-buckthorn medicinal substrate oil according to claim 1 produces production technology, it is characterized in that：It is separated twice In process, separation for the first time is separated using butterfly seperator, and second of separation is separated using rod-type seperator, is separated Rotating speed is at 3000 to 5000 revs/min.
CN201611017898.9A 2016-11-20 2016-11-20 The low temperature of sea-buckthorn medicinal substrate oil produces production technology Pending CN108085125A (en)

Priority Applications (1)

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CN201611017898.9A CN108085125A (en) 2016-11-20 2016-11-20 The low temperature of sea-buckthorn medicinal substrate oil produces production technology

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Application Number Priority Date Filing Date Title
CN201611017898.9A CN108085125A (en) 2016-11-20 2016-11-20 The low temperature of sea-buckthorn medicinal substrate oil produces production technology

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Application publication date: 20180529