CN108079234A - 改善骨关节细胞新陈代谢并激活骨关节细胞膏的制备方法 - Google Patents
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Abstract
本发明公开了一种改善骨关节细胞新陈代谢并激活骨关节细胞膏的制备方法,原料重量配比为:川芎提取物5—8份,路路通提取物15—17份,伸筋草提取物10—12份,三棱提取物12—15份,丁香油5—8份,肉桂油4—6份,透骨草提取物8—10份,红花提取物5—7份,羌活提取物8—10份,独活提取物4—6份,川乌提取物3—5份,尿囊素8—10份,桂枝提取物10—12份,丙烯酰二甲基牛磺酸铵0.5—0.8份,聚山梨醇酯‑80 0.5—0.8份,异十六烷0.1—0.3份,甘油0.1—0.3份,透明质酸钠0.5—1.5份,本发明让干细胞快速增长,从而达到改善关节功能的作用。
Description
技术领域
本发明涉及一种骨关节细胞膏的制备方法,具体涉及一种改善骨关节细胞新陈代谢并激活骨关节细胞膏的制备方法。
背景技术
骨关节炎(OA)是一种痛苦的慢性病 ,会严重影响患者的生活质量。且到目前为止没有针对这种慢性病的有效治疗方法。在全球范围内,骨关节炎患者的数量正在不断增长,预计到2050年会达到1.3亿。无论是在中国还是在其他欧美国家,骨关节炎的治疗对于患者而言都会产生巨大的经济负担。
干细胞是能够分化为肌肉骨骼组织的多能内源性祖细胞群,具有明确的免疫调节作用,主要通过旁分泌信号来控制炎症反应。近年来,中国的医疗学术期刊中(« 广东医学»,2013年9月刊)就已经提出将干细胞作为骨关节炎患者的潜在再生细胞治疗源。干细胞具有天然存在、临床效果显著、无副作用等优势,而其中 “激活干细胞”的治疗效果尤为显著。
发明内容
本发明的目的是针对上述现有技术的缺陷,提供了一种改善骨关节细胞新陈代谢并激活骨关节细胞膏的制备方法,本发明可使皮肤黏膜充血扩张,使药物的有效成分能渗透到关节组织内;使干细胞激活,让其干细胞快速增长,从而达到改善关节功能的作用。
本发明的目的可以通过以下技术方案实现 :改善骨关节细胞新陈代谢并激活骨关节细胞膏的制备方法,其特征在于如下步骤,其中,原料重量配比为:(1)川芎提取物5—8份,(2)路路通提取物15—17份,(3)伸筋草提取物10—12份,(4)三棱提取物12—15份,(5)丁香油5—8份,(6)肉桂油4—6份,(7)透骨草提取物8—10份,(8)红花提取物5—7份,(9)羌活提取物8—10份,(10)独活提取物4—6份,(11)川乌提取物3—5份,(12)尿囊素8—10份,(13)桂枝提取物10—12份,(14)丙烯酰二甲基牛磺酸铵0.5—0.8份,(15)聚山梨醇酯-800.5—0.8份,(16)异十六烷0.1—0.3份,(17)甘油0.1—0.3份,(18)防腐剂0.03—0.05份,(19)透明质酸钠0.5—1.5份,(20)着色剂0.1—0.3份;
所述步骤如下:
A、将(1)—(13)按上述比例混合均匀后,得调理料;
B、将原料(14)—(16)混合,得混合料,按混合料:水的重量比1:2兑水加热至摄氏80度,再加入(17)、(18)得加热的混合溶液;
C、将步骤A得到的调理料按调理料:水的重量比1:5兑水加热至摄氏100度,沸腾2—5分钟,慢慢倒入步骤B得到的加热的混合溶液中,边倒边沿同一方向搅拌,当温度降至6 0℃左右时,将(19)、(20)倒入上述混合溶液中,快速搅拌至半固体状即得到改善骨关节细胞新陈代谢并激活骨关节细胞膏。
所述着色剂为香兰基丁基醚或CI19140或CI42090。
所述防腐剂为双(羟甲基)咪唑烷基脲或羟苯甲酯。
本发明的有益效果 :本发明所用中药不但具有激活干细胞的作用,而且能活血通络、祛风除湿。两者协同作用可加速局部血液干细胞再生和淋巴液的循环,减轻静脉瘀滞,降低骨内压力,促进关节积液吸收,缓解疼痛和肿胀,从而达到改善关节功能的作用。
具体实施方式
下面结合实施例对本发明的具体实施方式作进一步详细说明。
其特征在于如下步骤,其中,原料重量配比为:(1)川芎提取物5—8份,(2)路路通提取物15—17份,(3)伸筋草提取物10—12份,(4)三棱提取物12—15份,(5)丁香油5—8份,(6)肉桂油4—6份,(7)透骨草提取物8—10份,(8)红花提取物5—7份,(9)羌活提取物8—10份,(10)独活提取物4—6份,(11)川乌提取物3—5份,(12)尿囊素8—10份,(13)桂枝提取物10—12份,(14)丙烯酰二甲基牛磺酸铵0.5—0.8份,(15)聚山梨醇酯-80 0.5—0.8份,(16)异十六烷0.1—0.3份,(17)甘油0.1—0.3份,(18)防腐剂0.03—0.05份,(19)透明质酸钠0.5—1.5份,(20)着色剂0.1—0.3份;
所述步骤如下:
A、将(1)—(13)按上述比例混合均匀后,得调理料;
B、将原料(14)—(16)混合,得混合料,按混合料:水的重量比1:2兑水加热至摄氏80度,再加入(17)、(18)得加热的混合溶液;
C、将步骤A得到的调理料按调理料:水的重量比1:5兑水加热至摄氏100度,沸腾2—5分钟,慢慢倒入步骤B得到的加热的混合溶液中,边倒边沿同一方向搅拌,当温度降至6 0℃左右时,将(19)、(20)倒入上述混合溶液中,快速搅拌至半固体状即得到改善骨关节细胞新陈代谢并激活骨关节细胞膏。
所述着色剂为香兰基丁基醚或CI 19140或CI 42090。
所述防腐剂为双(羟甲基)咪唑烷基脲或羟苯甲酯。
以下给出本发明的实施例。
实施例 1
其特征在于如下步骤,其中,原料重量配比为:(1)川芎提取物5份,(2)路路通提取物15份,(3)伸筋草提取物10份,(4)三棱提取物12份,(5)丁香油5份,(6)肉桂油4份,(7)透骨草提取物8份,(8)红花提取物5份,(9)羌活提取物8份,(10)独活提取物4份,(11)川乌提取物3份,(12)尿囊素8份,(13)桂枝提取物10份,(14)丙烯酰二甲基牛磺酸铵0.5份,(15)聚山梨醇酯-80 0.5份,(16)异十六烷0.1份,(17)甘油0.1份,(18)羟苯甲酯0.03份,(19)透明质酸钠0.5份,(20)香兰基丁基醚0.1份;
所述步骤如下:
A、将(1)—(13)按上述比例混合均匀后,得调理料;
B、将原料(14)—(16)混合,得混合料,按混合料:水的重量比1:2兑水加热至摄氏80度,再加入(17)、(18)得加热的混合溶液;
C、将步骤A得到的调理料按调理料:水的重量比1:5兑水加热至摄氏100度,沸腾2—5分钟,慢慢倒入步骤B得到的加热的混合溶液中,边倒边沿同一方向搅拌,当温度降至6 0℃左右时,将(19)、(20)倒入上述混合溶液中,快速搅拌至半固体状即得到改善骨关节细胞新陈代谢并激活骨关节细胞膏。
实施例 2
其特征在于如下步骤,其中,原料重量配比为:(1)川芎提取物6份,(2)路路通提取物16份,(3)伸筋草提取物11份,(4)三棱提取物13份,(5)丁香油7份,(6)肉桂油5份,(7)透骨草提取物9份,(8)红花提取物6份,(9)羌活提取物9份,(10)独活提取物5份,(11)川乌提取物4份,(12)尿囊素9份,(13)桂枝提取物11份,(14)丙烯酰二甲基牛磺酸铵0.6份,(15)聚山梨醇酯-80 0.7份,(16)异十六烷0.2份,(17)甘油0.2份,(18)双(羟甲基)咪唑烷基脲0.04份,(19)透明质酸钠1份,(20)CI 19140 0.2份;
制作步骤同实施例1
实施例 3
其特征在于如下步骤,其中,原料重量配比为:(1)川芎提取物8份,(2)路路通提取物17份,(3)伸筋草提取物12份,(4)三棱提取物15份,(5)丁香油8份,(6)肉桂油6份,(7)透骨草提取物10份,(8)红花提取物7份,(9)羌活提取物10份,(10)独活提取物6份,(11)川乌提取物5份,(12)尿囊素10份,(13)桂枝提取物12份,(14)丙烯酰二甲基牛磺酸铵0.8份,(15)聚山梨醇酯-80 0.8份,(16)异十六烷0.3份,(17)甘油0.3份,(18)双(羟甲基)咪唑烷基脲0.05份,(19)透明质酸钠1.5份,(20)CI 19140 0.3份;
制作步骤同实施例1
Claims (3)
1.改善骨关节细胞新陈代谢并激活骨关节细胞膏的制备方法,其特征在于如下步骤,其中,原料重量配比为:(1)川芎提取物5—8份,(2)路路通提取物15—17份,(3)伸筋草提取物10—12份,(4)三棱提取物12—15份,(5)丁香油5—8份,(6)肉桂油4—6份,(7)透骨草提取物8—10份,(8)红花提取物5—7份,(9)羌活提取物8—10份,(10)独活提取物4—6份,(11)川乌提取物3—5份,(12)尿囊素8—10份,(13)桂枝提取物10—12份,(14)丙烯酰二甲基牛磺酸铵0.5—0.8份,(15)聚山梨醇酯-80 0.5—0.8份,(16)异十六烷0.1—0.3份,(17)甘油0.1—0.3份,(18)防腐剂0.03—0.05份,(19)透明质酸钠0.5—1.5份,(20)着色剂0.1—0.3份;
所述步骤如下:
A、将(1)—(13)按上述比例混合均匀后,得调理料;
B、将原料(14)—(16)混合,得混合料,按混合料:水的重量比1:2兑水加热至摄氏80度,再加入(17)、(18)得加热的混合溶液;
C、将步骤A得到的调理料按调理料:水的重量比1:5兑水加热至摄氏100度,沸腾2—5分钟,慢慢倒入步骤B得到的加热的混合溶液中,边倒边沿同一方向搅拌,当温度降至6 0℃左右时,将(19)、(20)倒入上述混合溶液中,快速搅拌至半固体状即得到改善骨关节细胞新陈代谢并激活骨关节细胞膏。
2.按权利要求1所述改善骨关节细胞新陈代谢并激活骨关节细胞膏的制备方法,其特征在于所述着色剂为香兰基丁基醚或CI 19140或CI 42090。
3.按权利要求1所述改善骨关节细胞新陈代谢并激活骨关节细胞膏的制备方法,其特征在于所述防腐剂为双(羟甲基)咪唑烷基脲或羟苯甲酯。
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